47 results about "Body organs" patented technology

The invention provides an application of a compound Aldometanib in preparation of a medicine for preventing and treating immune-related adverse reactions and diseases. Based on the first discovered prevention and treatment effects of Aldometanib on fatal immune hepatitis, immune myocarditis, pneumonia and enteritis, the invention specifically discloses application of Aldometanib in preparation of drugs for prevention and treatment of immune-related adverse reactions and diseases, and the main mechanism is that Aldometanib activates immune cells AMPK, enhances catabolism of immune cells, promotes immune cell apoptosis, promotes immune cell apoptosis, and improves immune cell apoptosis. The anabolism of the immune cells is inhibited, so that the expression of effector factors of the immune cells is controlled, and inflammatory factor storm is inhibited. Aldometanib has the effects of preventing the occurrence of immune-related adverse reactions and diseases, and inhibiting the attack levels of the immune-related adverse reactions and diseases, so that non-lethal and lethal injuries caused by an immune system to body organs are reduced.

The invention relates to internet-of-things digital intelligent medicine and medicine interaction virtual-real fusion terminal equipment, and aims to solve the problem of medicine selection deviation caused by insufficient medical knowledge of a user in a traditional medicine purchasing process. The device obtains user symptoms through multi-mode interaction (voice, touch screen and video), generates a combined medication scheme based on a cloud medical knowledge base and a medicine database, and introduces a doctor, pharmacist and licensed pharmacist auditing mechanism to guarantee scientific medication and safe medication of the user. The system supports four payment modes and two medicine taking modes (self-pick-up / delivery), realizes full-process intelligentization from symptom analysis to medicine delivery, and adapts to full-process digitalization from body organ part-part symptom to medicine delivery in local dialects. According to the method, the user can be guided to accurately purchase medicines with scientific and safe medication according to the disease symptoms, the correspondence between the medicines purchased by the user and the disease symptoms is improved, the risk of wrong medication of the user is reduced, and the accuracy of scientific and professional medication is improved.

A method and system for assisting a physician compute the 3D location of the tip of a surgical device inserted into a patient is described. A trained model computes the 3D location of the hidden portion of the surgical device based on live image data of the operative field. A display shows the tip of the surgical device and a 3D model of the body organ in a fused arrangement.

The invention relates to an arrangement for delivering a medical implant into a hollow body organ (100) comprising a wire (10) and a compressible and expandable medical implant (11) which is tubular in shape, wherein the implant (11) in the compressed state is detachably connected to the wire (10) by at least one engagement element (12), wherein the engagement element (12) has a plurality of filaments (13) which extend outwards in the radial direction of the wire (10) and engage in the implant (11) during use.

The application relates to a whole-body organ metabolism network analysis method, device, equipment and storage medium. The method comprises the following steps: collecting a PET image of a subject, obtaining SUV images, Ki images and TAC data according to the PET image, and collecting physiological information, clinical pathology information and daily habit information of the subject; metabolism characteristics are extracted based on the PET images, SUV images and Ki images corresponding to the region of interest; the TAC data of each organ is curve-fitted by using the PET image, and the metabolism disturbance under different organs is represented by using the fitting residual error; a whole-body organ metabolism network is constructed according to the physiological information, clinical pathology information, daily habit information, metabolism characteristics and metabolism disturbance; and the whole-body organ metabolism of the subject is analyzed through the whole-body organ metabolism network. The application avoids individual differences, can more comprehensively capture the metabolism correlation among whole-body organs of a specific disease, and is helpful for early diagnosis, accurate evaluation and individualized treatment of clinical diseases.

An apparatus for use in tissue removal from a body organ is presented. The apparatus comprises a hand-held probe device, a rotating motor device and a connection assembly configured for removably interconnecting between the hand-held probe device and the rotating motor device. The hand-held probe device is disposable and comprises a housing having proximal and distal ends, a rotatable cutting tool extending distally from the distal end of the housing and being configured for cutting and removing tissue during rotation, and a transmission assembly passing inside the housing between the proximal and distal ends and being configured for transmitting rotational power to the rotatable cutting tool. The connection assembly is configured for engaging between the rotating motor device and the transmission assembly to thereby controllably rotate the cutting tool and remove tissue. In some embodiments, the apparatus includes a control unit for controlling operation of the apparatus, the control unit comprises an activation mechanism for activating the rotatable cutting tool, and a controller configured for operating the activation mechanism to generate a single fixed activation signal of a known intensity and duration during a predetermined time interval, thereby restricting operation of the cutting tool during the time interval to the single activation signal only.

The present invention relates to an artificial contractile device comprising at least one contractile element (1) comprising a flexible strip (4) extending in a longitudinal direction and a closure (6) for forming the contractile element (1) into a closed loop around a hollow body organ, the closure (6) being situated at a first extremity of the flexible strip (4). The contractile element is adapted to contract a hollow body organ, in such a way that said contractile element (1) may be in a resting position or in an activated position. The artificial contractile device further comprises a flexible transmission (3) comprising a tensioning element (31) being anchored at a first end (311) to a first anchoring point (A) on the flexible strip (4), said flexible transmission (3) being adapted to tighten the contractile element (1) formed in a closed loop around said hollow body organ upon application of a traction force at and end of the tensioning element (2031) by an actuator (7). The artificial contractile device also comprises a connector (5) adapted to connect the flexible transmission (3) to a said actuator (7), a second end (312) of said tensioning element (2031) being anchored in said connector (5).

Apparatuses and methods for facilitating the guided delivery of a drug into a patient's body organ are disclosed. An apparatus (2500) for facilitating the guided delivery of a drug into a patient's body organ can include a container (2504) configured to package a drug, a needle (2502) having a passage therethrough and a sharp distal tip, and a needle sheath (2506) at least partially surrounding a shaft of the needle. The needle sheath can include a distal surface, wherein the sharp distal tip of the needle can be configured to extend through an opening in the distal surface. The needle sheath can be movable relative to the needle along an axis of the needle to control a distance from the distal surface to the distal tip of the needle.

A biopsy guide for guiding biopsy needles towards a body organ includes a clasp for attaching to an ultrasound probe. The biopsy guide includes in addition a guide tower extending upwards away from the clasp that in turn includes a plurality of parallel guide channels placed one above the other and defining each a needle passage that extends through the guide tower between rear and forward open ends. Each guide channel at least along a rear section thereof opens laterally sideways along a slit that has a width sized to be generally similar to or larger than a width of the needle passage.

Devices, systems, and methods for localized delivery of a chemotherapy, hormonal therapy, or targeted drug / biologic therapy to a target tissue area of an internal body organ of a patient. Computer systems may be used for planning and navigation in super selective drug delivery via a tracheobronchial airway. A catheter may be used to form a sealed treatment chamber in a natural lumen extending through the target tissue area. Air is purged from the chamber, which is then filled with a liquid drug solution for an adequate treatment session time, solution volume and drug concentration to saturate the target tissue area, thereby providing the treatment. The liquid drug solution may be circulated or recirculated through the chamber or maintained stationary therewithin to saturate the target tissue area. The chamber is evacuated at the end of the treatment session.

A lead structure according to an embodiment of the present disclosure may include: includes a lead having an electrode wire having one end provided as an insertion portion to be inserted into a body and the other end provided as an interface portion for connection with an external device, a first electrode in the insertion portion to transmit electrical stimulation to body organs, a second electrode on the interface portion to receive electrical stimulation applied from outside, and a signal line configured to interconnect the first electrode and the second electrode and transmit the electrical stimulation received by the second electrode to the first electrode; and a lead case configured to surround the lead, and a conductive plate configured to apply electrical stimulation to body organs and a support plate configured to provide electrical stimulation from the first electrode to the conductive plate by contacting the first electrode.

Combinations of cannabinoids, vitamins, trace elements, bioactive components, bioflavonoid polyphenols, proteolytic enzymes, amino acids, and antioxidants which work independently and synergistically for the prevention, treatment, and inhibition of excess cytokines caused by the immune response to extreme viral and bacterial infections, including the inhibition of COVID-19, Rhinovirus and / or other virus spike proteins and mRNA vaccine spike proteins from attaching to body organ cells, penetrating cell membranes, and the replication of virus particles and spike proteins inside the cells. Inhibition of inflammation and prevention of long-term side effects, health issues (long-haulers), and disease caused by the SARS-COV-2 and its variants, Rhinovirus, other viruses, bacteria, and mRNA vaccines are provided by the nutraceutical compositions. Specific combinations of these compounds work synergistically to increase the efficacy of the independent nutraceuticals in treatment.

The invention relates to an arrangement for feeding a radially compressible and expandable implant (10) into a hollow body organ, comprising a transport wire (11) having an engagement element (12), wherein the implant (10) is tubular and, in the compressed state, is detachably connected to the transport wire (11) by the engagement element (12), and wherein the implant (10), in the at least partially expanded state, can be released by a relative movement between the engagement element (12) and the implant (10) in a release direction, wherein the transport wire (11) has a positioning element (13) with a plurality of flexible windings extending in the radial direction of the transport wire (11), wherein an outer contour of the engagement element (12) in the released state of the implant (10) is smaller than a contour of the positioning element (13), such that the engagement element (12) can be positioned in the implant (10).

Combinations of cannabinoids, vitamins, trace elements, bioactive components, bioflavonoid polyphenols, proteolytic enzymes, amino acids, and antioxidants which work independently and synergistically for the prevention, treatment, and inhibition of excess cytokines caused by the immune response to extreme viral and bacterial infections, including the inhibition of COVID-19, Rhinovirus and / or other virus spike proteins and mRNA vaccine spike proteins from attaching to body organ cells, penetrating cell membranes, and the replication of virus particles and spike proteins inside the cells. Inhibition of inflammation and prevention of long-term side effects, health issues (long-haulers), and disease caused by the SARS-CoV-2 and its variants, Rhinovirus, other viruses, bacteria, and mRNA vaccines are provided by the nutraceutical compositions. Specific combinations of these compounds work synergistically to increase the efficacy of the independent nutraceuticals in treatment.

Among other things, there are disclosed embodiments of belts or bands that can be used in treatments for tricuspid valve regurgitation. In some embodiments, such belts may be heat-set in a particular configuration to effectively decrease tricuspid annulus when deployed around the atrioventricular groove. Embodiments include one or more tensioning sutures for applying cinching or tightening to belts when deployed, and structure for effectively distributing force during such tightening.

1. Arrangement for delivering a medical implant into a hollow body organ, comprising a wire (10) and a compressible and expandable medical implant (11) which is tubular in shape, - wherein the implant (11) in the compressed state is detachably connected to the wire (10) by at least one engagement element (12) for transmitting force in the axial direction, wherein the engagement element (12) has at least one projection (13) which extends radially outwards and engages the implant (11), and - wherein the implant (11) in the at least partially expanded state can be released by a relative movement between the engagement element (12) and the implant (11) in a release direction, characterized in that the engagement element (12) has at least one sliding surface (14) which is inclined and / or curved in the release direction and cooperates with the projection (13) to release the implant (11).

A lead structure includes a lead having an electrode wire having one end provided as an insertion portion to be inserted into a body and the other end provided as an interface portion for connection with an external device, a first electrode in the insertion portion to transmit electrical stimulation to body organs, a second electrode on the interface portion to receive electrical stimulation applied from outside, and a signal line configured to interconnect the first electrode and the second electrode and transmit the electrical stimulation received by the second electrode to the first electrode; and a lead case configured to surround the lead, and a conductive plate configured to apply electrical stimulation to body organs and a support plate configured to provide electrical stimulation from the first electrode to the conductive plate by contacting the first electrode.

The application belongs to the technical field of animal vaccine preparation, and discloses an African swine fever virus (ASFV) multi-epitope fusion protein, a ferritin nanoparticle vaccine of the ASFV multi-epitope fusion protein and application. The application obtains 16 dominant B cell epitopes by using an ASFV phage display library in combination with reverse screening of clinical positive serum, and constructs a nanoparticle vaccine by linking the 16 epitopes with ferritin self-assembly. The vaccine has excellent biosafety, can induce high-level and sustained specific antibodies and significant IFN-gamma cellular immune response in pigs, can effectively delay the clinical onset and death process of pigs in ASFV virulent challenge experiments, and can significantly reduce the virus load in whole-body organ tissues, thereby providing 25% survival protection rate. The application provides an effective new strategy for the development of a subunit vaccine for responding to various ASFV mutant strains.

The invention discloses a valve clamping device and a preparation method thereof, the valve clamping device is made of a degradable high polymer material doped with a developing component, and the surface of the valve clamping device is covered with a degradable drug coating. The valve clamping device is safe and non-toxic, can be degraded into water and carbon dioxide in vivo, and has small burden on body organs. The surface of the valve clamping device is coated with a degradable medicine coating, and the risk of causing inflammation, tissue hyperplasia and thrombus after the valve clamping device is implanted into a human body is low. Due to the introduction of the developing component, the valve clamping device can be positioned in vivo in real time by virtue of developing equipment, so that a replacement operation of the valve clamping device can be conveniently carried out as required under specific conditions, such as when the valve clamping device is not completely degraded.

The application provides a disease diagnosis method based on image and clinical data and a related device. The method comprises: performing feature extraction processing on a medical image based on a spatial dimension and a time dimension to obtain a medical image feature, wherein the medical image is a medical image of a specific body organ of a patient; performing feature extraction processing on patient clinical data to obtain a clinical data feature, wherein the patient clinical data comprises clinical data of the patient and / or clinical data of a specific disease patient, and the specific disease patient refers to a patient who has a specific disease in the specific body organ; fusing the image feature and the clinical data feature to obtain a fusion feature, and performing classification based on the fusion feature to obtain a classification result, wherein the classification result is used to indicate whether the patient has the specific disease. The method can improve the disease diagnosis accuracy.

A medical catheter (10) for insertion into a hollow body organ having at least one proximal section and one distal section (11), the catheter (10) comprising: - at least one feed channel (12) for feeding a medical implant; - a liner (13) formed by spirally winding a layer (14) onto a mandrel (15) and designed as an inner layer of the catheter (10) facing an inner lumen (16) of the supply channel (12) during use; and - a jacket (17) which forms an outer layer of the catheter (10), characterized in that the wall thickness of the liner (13) in the distal section (12) is between 20% and 50% of the total wall thickness of the catheter (10), wherein the liner (13) comprises several layers (14) which are arranged one above the other in the radial direction of the catheter (10).

A method for generating a skeleton in an image of a cavity of an organ of a body includes receiving a map of the cavity, the map including surface voxels and interior voxels. A subset of the interior voxels is generated, of candidate locations to be on the skeleton. The subset is pruned by removing outlier candidate locations. Using a geometrical model including a statistical model, the candidate locations remaining in the pruned subset are spatially compressed. The compressed candidate locations are connected to produce one or more centerlines of the skeleton. At least the skeleton is displayed to user.

An apparatus for controlling the flow of fluids and / or body substances in a lumen formed by a tissue wall of a patient's organ, comprising: an implantable compression device for gently compressing (i.e., not significantly damaging the blood circulation of the tissue wall) at least a portion of the tissue wall to affect the flow in the lumen; and stimulation means for stimulating a wall portion of the tissue wall. The control device controls the stimulation device to stimulate the wall portion when the compression device presses the wall portion such that contraction of the wall portion due to compression of the compression device further affects flow in the lumen. The device can be used to limit or stop flow in a lumen, or to effectively move fluid in a lumen, with low risk of organ injury.

The present invention provides an improved vascular occlusion device having improved flexibility and retention of the type fabricated from braided tubular metal fabric having an expanded preset configuration and an elongated collapsed reduced diameter configuration for delivery through a catheter to a treatment site and shaped to create an occlusion of an abnormal opening in a body organ or vessel, the woven metal fabric having a memory property whereby the medical device tends to return to said expanded preset configuration when unconstrained. The device further including at least one disk portion adjacent a body cylindrical portion formed from the fabric and having a transition diameter between the disk and cylindrical portion, significantly smaller than the diameter of the disk and the diameter of the cylindrical portion.

A lead structure according to an embodiment of the present disclosure may include: includes a lead having an electrode wire having one end provided as an insertion portion to be inserted into a body and the other end provided as an interface portion for connection with an external device, a first electrode in the insertion portion to transmit electrical stimulation to body organs, a second electrode on the interface portion to receive electrical stimulation applied from outside, and a signal line configured to interconnect the first electrode and the second electrode and transmit the electrical stimulation received by the second electrode to the first electrode; and a lead case configured to surround the lead, and a conductive plate configured to apply electrical stimulation to body organs and a support plate configured to provide electrical stimulation from the first electrode to the conductive plate by contacting the first electrode.

The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.

Among other things, there are disclosed embodiments of belts or bands that can be used in treatments for tricuspid valve regurgitation. In some embodiments, such belts may be heat-set in a particular configuration to effectively decrease tricuspid annulus when deployed around the atrioventricular groove. Embodiments include one or more tensioning sutures for applying cinching or tightening to belts when deployed, and structure for effectively distributing force during such tightening.

An apparatus for use in tissue removal from a body organ is presented. The apparatus comprises a hand-held probe device, a rotating motor device and a connection assembly configured for removably interconnecting between the hand-held probe device and the rotating motor device. The hand-held probe device is disposable and comprises a housing having proximal and distal ends, a rotatable cutting tool extending distally from the distal end of the housing and being configured for cutting and removing tissue during rotation, and a transmission assembly passing inside the housing between the proximal and distal ends and being configured for transmitting rotational power to the rotatable cutting tool. The connection assembly is configured for engaging between the rotating motor device and the transmission assembly to thereby controllably rotate the cutting tool and remove tissue. In some embodiments, the apparatus includes a control unit for controlling operation of the apparatus, the control unit comprises an activation mechanism for activating the rotatable cutting tool, and a controller configured for operating the activation mechanism to generate a single fixed activation signal of a known intensity and duration during a predetermined time interval, thereby restricting operation of the cutting tool during the time interval to the single activation signal only.

Embodiments include methods for draining fluids from a body organ, such as pericardiocentesis. Embodiments include inserting a large diameter outer needle through the chest wall towards an organ, inserting a smaller diameter microneedle through the outer needle and into the organ, threading a microwire through the lumen of the inner microneedle into the organ, removing the outer needle and inner microneedle, threading a guide sheath over the microwire into the organ, removing the inner dilator and microwire from the guide sheath, inserting a stiffer guide wire through the guide sheath into the organ, removing the guide sheath, threading a drain sheath over the stiffer guide wire into the organ, removing the stiffer guide wire, securing the drain sheath to the patient using a stay fix device, and connecting a suction device to the proximal end of the drain sheath and creating negative pressure to facilitate fluid drainage.