38 results about "Drug Contamination" patented technology

The invention discloses a microbial purifying ecological treatment system of a landscape water body, which comprises a first-stage filter tank (1), a second-stage biochemical pool (2), a third-stage biochemical pool (3), a fourth-stage reduction pool (4), a fifth-stage clean water pool (5), and a pollution discharge pool (6). The invention adopts micro-power circulation, filtration and sedimentation, utilizes a microbial contact oxidation method, via a multi-stage artificial beneficial microbial culture bed, by a technical proposal that an aerobic beneficial microorganism takes in and degrades the organic pollutant, nitrogen and phosphorus plant nutrient, and then a ultraviolet ray implements sterilization and disinfection for purifying and restoring the clear water, and thus solving the problems and shortcomings of high cost, water source restriction, drug contamination, and lower removal rate which exist in the prior art. The microbial purifying ecological treatment system of the landscape water body can lead the purifying treatment of the landscape water body to achieve the purposes of easy control, high removal, low cost, non-needing water change, and non-drug pollution by the way of artificially cultivating aerobic beneficial microbial ecological circular automatic purification.

A packaging system is described for a drug that provides protection from contamination, crystallization and / or degradation of the drug during storage of the system prior to its use. The packaging of the drug does not significantly absorb, react with, or otherwise adversely affect the therapeutic effectiveness of the drug or other excipients or components during storage of the system prior to its use. The packaging system is also used for preserving a drug, particularly a drug containing high-purity texaphyrin metal complexes, by providing a product packaging system that prevents, limits or otherwise controls degradation reactions that can result from exposure to oxygen and / or light.

The present invention discloses a prefilled syringe filling machine, including an external package removal area, an internal package removal area, a filling and stoppering area being arranged to be adjacent to the internal package removal area, a rubber plug buffer area and a conveyor belt penetrating through the internal package removal area from the external package removal area, a first transfer device is arranged in the internal package removal area; a second transfer device is arranged in the filling and stoppering area; a material delivery port is arranged between the filling and stoppering area and the internal package removal area; at work, the first transfer device transfers materials on the conveyor belt to the material delivery port so as to deliver the materials to the second transfer device, the second transfer device carries the materials and, after accomplishing filling and stoppering the materials, transfers the materials to the material delivery port so as to deliver the materials to the first transfer device, and the first transfer device transfers the materials onto the conveyor belt. The present invention has the advantages of having a simple structure and being able to effectively reduce the risk of drug contamination.

The invention relates to a method for removing drugs in soil by utilizing magnetism molecular imprinting-electromagnetism grating combination. The drugs are one or more of carbamazepine, clofibric acid or diclofenac. The method comprises the following specific steps of: fully mixing preprocessed soil and a magnetism molecularly imprinted polymer, absorbing the drugs in the soil on the surface of the magnetism molecular imprinting, and separating the water soil and the magnetism molecularly imprinted polymer after reaction through an electromagnetism grid; and absorbing the magnetism molecular imprinting on the grid through a magnetic field generated by the electromagnetism grid after electrification, and effectively separating the magnetism molecular imprinting and the grid. The method provided by the invention has the advantages that the operation is simple, the effect is obvious, the arbamazepine, the clofibric acid and the diclofenac and the like in the soil are removed in one time, the drugs absorbed on the magnetism molecular imprinting are recovered and separated through the electromagnetism grid; a magnetism molecular imprinting technology is utilized to restore the soil polluted by the drugs and has the advantages that the cost is low, the restoring efficiency is high and the like; and an electromagnetism grid device is utilized to recycle the resources, so that secondary pollution is not caused.

The invention discloses a cultivation method for yam bean rich in various microelements. Through combination of a hole fertilizer and a fertilizer for a seed bed, the yam bean seedling emergence speedis increased; nutritional ingredients capable of promoting the growth of plants are added into the fertilizer for the seed bed, the cultivation period is shortened, and economic benefits are increased; raw materials of a root tuber swelling fertilizer which is added in the middle and later periods are wide in source, the preparation method is simple, nutrition is rich, the swelling rate is high,the growing speed is high, the disease prevention performance is good, the planting cost is reduced while the quality and the yield of the yam bean are improved, and the yam bean is made to be rich invarious microelements; neither pigments nor antibiotic drugs are added in the cultivation process, the yam bean is environmentally friendly and free of drug contamination, and after eaten, the yam bean is harmless to the human body.

The invention provides a robotic assembly line for powder dispensing. The robotic assembly line for powder dispensing comprises a rotary platform used for holding a mother liquid bag, a powder bottleloading device used for pushing and arranging a powder bottle, a manipulator suction device used for taking medical liquid from the mother liquid bag and injecting the medical liquid into the powder bottle, a solution bottle flow steering device used for grabbing the powder bottle and cooperatively completing the injection of the medical liquid, a solution bottle swing mixing device used for receiving an original solution bottle and completing the mixing of powder and the medical liquid, a solution bottle transfer device used for grabbing and transporting the solution bottle after mixing, a solution bottle turning device used for receiving and turning over the solution bottle after mixing, and a manipulator injection device for pumping a solution from the solution bottle after mixing and injecting the solution into the mother liquid bag. The robotic assembly line for powder dispensing provided can realize automatic dispensing, allow manual operation without contacting drugs, prevent drug contamination and avoid harm to operators, the prepared solution is evenly mixed and stable, and the multi-dose dispensing efficiency is high.

The invention discloses a preparation technology of a Lysimachia christinae Hance freshly squeezed vacuum-dried powder decoction piece. The preparation technology comprises 1) pretreatment, 2) squeezing juicing, 3) mixing and filtration, 4) concentration, 5) drying granulation and 6) packaging. The preparation technology reduces a decoction piece size, maximally retains polar and non-polar active ingredients in Lysimachia christinae Hance, prevents an active ingredient loss and drug quality reduction caused by decoction piece processing, storage and transportation at present and reduces the risk of drug contamination. The preparation technology has a great significance to ensure the quality stability and clinical safety and effectiveness of Lysimachia christinae Hance.

The invention relates to an automatic dispensing device and method. The automatic dispensing device comprises a man-machine interaction module, a dispensing module, a disinfection module, a constant temperature module and a clarity detection module, wherein the man-machine interaction module is connected with a main control module and used for acquiring input patient information, retrieving doctor's advice information for a patient from a background according to the patient information, and transmitting the doctor's advice information to the main control module; the dispensing module is connected with the main control module and is used for scanning a drug container placed in a dispensing area according to a control signal of the main control module so as to obtain drug information according to drug information identification arranged on the surface of the drug container, and is used for judging whether the drug information is consistent with medication information, and if yes, a to-be-dispensed drug is dispensed; the disinfection module is used for disinfecting the dispensing area; the constant temperature module is used for maintaining the temperature of the dispensing area at adesired temperature; the clarity detection module is used for detecting whether the clarity of the drug meets the preset standard or not, and if yes, dispensing is completed. The device can realize automatic dispensing of the to-be-dispensed drug, dispensing efficiency is improved, and liquid drug contamination is avoided.

A dosing device for dispensing small-particulate pharmaceutical preparations has at least one chamber for receiving a larger amount of the preparation and a dosing unit. A rotary valve has at least one dosing chamber for receiving a defined dose of the preparation. The dosing chamber is moveable between a filling position and a dispensing position. The rotary valve rotates about a substantially horizontal axis, and has an adjustment device for setting the volume in the dosing chamber and a twisting device. The twisting device constitutes the actuator for the adjustment device. The device is made of a plastic material carefully selected to assure that no softening agents or other volatile components will be released, which prevents drug contamination.

The invention discloses a buried termite prevention cable distribution box, which comprises a shell, a stress supporting frame, a waterproof sleeve, cable connectors and insulating fireproof filling pieces, wherein the waterproof sleeve is arranged on the stress supporting frame in a sleeved mode, the cable connectors and the insulating fireproof filling pieces are installed in the shell, the stress supporting frame is partially arranged in the shell, and gaps between the stress supporting frame and the shell are filled with the insulating fireproof filling pieces; and the cable connectors are arranged in the stress supporting frame, and two ends of each cable connector are processed to be U-shaped ports. The buried termite prevention cable distribution box further comprises a termite protection sleeve, wherein the termite protection sleeve is arranged on the shell in a sleeved mode, and the termite protection sleeve is at least composed of a high-density polyethylene inner protection layer, an intermediate nylon protection layer and a high-density polyethylene outer protection layer. The three hard composite material protection layers of the termite protection layer on the distribution box significantly increase the termite damage prevention ability, greatly improve the ability of preventing biting of termites, and can enable the distribution box to acquire good termite prevention effects under environmental friendly and drug-contamination-free conditions.

The invention relates to a drug combination for curing the inflammation of vagina, which adopts the form of a foaming agent, in particular to a foaming agent with the principle agents being metronidazole, clotrimazole and chlorhexidine acetate. The drug combination has the advantages of even distribution, wide coating area and better effect in the vagina by adopting the form, and meanwhile, the drug combination feels more comfortable and has stronger retention property than other forms. In the formula of the foaming agent, the drug combination can permeate into the mucosal folds of the vagina rapidly and effectively by dispersing atomizing particles with the particle diameter being a few micrometers in a foaming manner under the action of pressure; the drug combination has higher absorption rate than the spraying agent with water being the only solvent with the assistance from various fat-soluble auxiliary materials; the drug contamination and the cross contamination are avoided during the administration; the invention has the advantages that the curative effect is fully produced, the administration is sanitary, convenient, safe and reliable without causing the foreign body sensation, and the drug combination is easily accepted by patients; and the invention further has the advantages of drug stability, form stability and long effective duration.

The invention discloses a preparation technology of a bitter gourd freshly squeezed vacuum-dried powder decoction piece. The preparation technology comprises 1) pretreatment, 2) squeezing juicing, 3) mixing and filtration, 4) concentration, 5) drying and granulation and 6) packaging. The preparation technology reduces a decoction piece size, maximally retains polar and non-polar active ingredients in the bitter gourd, prevents an active ingredient loss and drug quality reduction caused by decoction piece processing, storage and transportation at present and reduces the risk of drug contamination. The preparation technology has a great significance to ensure the quality stability and clinical safety and effectiveness of bitter gourd.

The invention discloses a medical medicine storage bin and a using method thereof, and relates to the technical field of medical storage. The medical medicine storage bin and the using method thereofaim at solving the problems of medicine pollution and difficulty in operation due to the fact that goods are inconvenient to store and take and medicines are easy to pollute in an existing medical medicine storage bin. A standby power supply is arranged at the rear end of a shell, an air inlet box is arranged at the lower end of the standby power supply, a monitoring camera is arranged on the front end of the shell, a monitoring operation panel is arranged on one side of the shell, a warehouse inlet is formed in the lower portion of the front end of the shell, a warehouse code scanning camerais arranged on the inner wall of the upper end of the warehouse inlet, a warehouse entering conveying belt is arranged below the warehouse code scanning camera, a dust removal fan is arranged at the rear end of the warehouse code scanning camera, a medicine containing plate is arranged at the upper end of the warehouse entering conveying belt, a dustproof soft plate is arranged at the rear end ofthe medicine containing plate, a sterilization ultraviolet lamp is arranged at the rear end of the dustproof soft plate, and a lifting column is arranged at the rear end of the warehousing entering conveying belt.

The invention discloses an outdoor compact and portable type quantitative medicine taking device and a using method thereof. The outdoor compact and portable type quantitative medicine taking device includes a medicine storage box and a medicine dispensing tube matched with the medicine storage box for use. Compared with the prior art, a medicine bottle and the medicine storage box are in communication through a medicine inlet, a sufficient amount of medicine is poured into the medicine storage box by dumping, after that, a first medicine dispensing mechanism is pushed out to block the mouth of the medicine bottle, the first medicine dispensing mechanism is rotated to close the medicine inlet when a circular barrier is in contact with the medicine inlet to complete the medicine feeding operation, no pollution is caused in the whole process, and the risk of primary contamination of the medicine in the medicine feeding process is avoided. The first medicine dispensing mechanism and a second medicine dispensing mechanism are adopted to realize the specific height of a medicine outlet, and through combination with a medicine storage cavity located in the first medicine dispensing mechanism, the storage of a plurality of tablets in the medicine storage cavity can be realized. The medicine storage cavity and a longitudinal medicine discharge path are designed on different axes, afterthe longitudinal medicine discharge path is placed horizontally and dumped, the tablets enter the medicine storage cavity, excess medicine temporarily stays in the longitudinal medicine discharge path, and the medicine in the medicine storage cavity can be conveniently taken out by sliding a flip cover, so that the purpose of quantitative medicine taking is achieved, and the design is more reasonable. The risks of medicine contamination caused by excessive medicine are avoided both in the medicine taking and medicine feeding processes, meanwhile, a cover body and the flip cover can well guarantee the sealing property of the device, and excellent performance is achieved.

The invention discloses a double-needle device for drug dispensing, and relates to the technical field of medical apparatus. The double-needle device comprises an injection needle body (1), a ventilating needle body (2), a filter screen (3) and a connecting tape (4), wherein the injection needle body (1) and the ventilating needle body (2) are connected by virtue of the connecting tape (4); and the filter screen (3) is arranged on the ventilating needle body (2). The double-needle device disclosed by the invention is simple in structure and convenient to operate, and the double-needle device can facilitate doctors to operate; and meanwhile, the double-needle device can achieve sterile operation, so that drug contamination is avoided.

The invention relates to an adjustable table-type anti-reflow aerosol inhalation fixing device, changes the whole process that nursing staff or family members need to hold a nebulizer for operation until nebulization ends during traditional aerosol inhalation, greatly improves work efficiency, lowers labor of nursing staff, avoids drug contamination, drug waste and cross infection, and makes patients more satisfied. The adjustable table-type anti-reflow aerosol inhalation fixing device comprises a nebulizer supporting and fixing clamp, a flexible support tube, a bedhead fixing clamp, and an anti-reflow nebulization device. The adjustable table-type anti-reflow aerosol inhalation fixing device can be fixed on the head of a bed through the rightmost bedhead fixing clamp which is connected with the flexible support tube in the middle. The anti-reflow nebulization device is disposed at the front end of a leftmost nebulizer and comprises a nebulizer outlet connecting tube, a stainless steel precision ball, a stainless steel non-return small spring and a nebulizing nozzle. The nebulizer outlet connecting tube of the anti-reflow nebulization device is connected with a nebulization inhaler. The adjustable table-type anti-reflow aerosol inhalation fixing device can be adjusted according to body positions of a patient and also prevent cross infection caused by aerosol reflowing.

The invention discloses a device for quantitative intranasal brain targeting drug delivery and drug storage containers. The device comprises a sprayer and a bottle body, the sprayer is fixedly connected with or detachably mounted on the bottle body, the bottle body is internally provided with a drug delivery chamber, a gas extrusion chamber and a containing chamber for storing drug modules separately, a partition plate which can be inserted and pulled out is arranged between the drug delivery chamber and the containing chamber, and the containing chamber is also internally provided with a cartridge-like structure used for pushing the drug modules toward the drug delivery chamber; each drug module comprises the corresponding sealed drug storage container filled with drugs, the container wall of each drug storage container is made of a hard material, and the portion, corresponding to an inlet end of a drug delivery pipe and a gas outlet end of a vent pipe I, of each container wall is provided with a sealed film-like structure. The device is detachable, modular in design and convenient to assemble, use, clean and maintain, the sprayer of the drug delivery device can be disassembled, the device can be used exclusively for special people, and regular updating can also prevent drug contamination and cross infection. The detachability of the drug device provides convenience for storage and management, and the device is suitable for being assembled for troops.

The invention belongs to the technical field of medical devices, and particularly relates to an automatic medicine arranging device for a pharmacy. The automatic medicine arranging device comprises abase, a medicine arranging disc, a control box and a slideway; the top of the base is slidably connected with the medicine arranging disc, and the left side wall of the base is fixedly connected withthe control box through screws; and the top of the control box is fixedly connected with a reciprocating motor through a bolt, the right side wall of the reciprocating motor is fixedly connected withthe slideway through a screw, and an inner groove is integrally formed in and connected to the inner side of the base. According to the automatic medicine arranging device for the pharmacy, through combined application of accessories, the inner groove is formed in the base, so that the medicine arranging disc is conveniently arranged insides in a matched manner; and the reciprocating motor is driven by matching with the control box, so that a guide column in the slideway can be matched with a rack rail to drive a medicine arranging column, medicines placed in a medicine feeding funnel can be arranged in circular holes of a top plate in the moving process, the purpose of automatic medicine arranging is achieved, and the defects of medicine pollution and low labor efficiency caused by directcontact are avoided.

The invention discloses a novel medicine box. The novel medicine box comprises a bottle body and a bottle cap hinged to the bottle body, wherein a knife groove is formed in the inner surface of the bottle cap; a cross-shaped blade is installed in the knife groove; a medicine containing area for containing tablets is arranged in the middle of the upper end face of the bottle body; a spring assemblyfor fixing the tablets is further arranged on the upper end face of the bottle body; the spring assembly is a pair of two springs which are parallel to each other and staggered; the opposite ends ofthe two springs are connected with limiting blocks used for limiting the tablets; and the other ends of the two springs are connected with the side end surface of the bottle body. Compared with the prior art, the novel medicine box integrates medicine cutting, medicine grinding and medicine storage, and is simple in structure, high in operation safety coefficient, uniform in medicine cutting, capable of avoiding medicine pollution and convenient to carry.

The embodiment of the invention discloses a bag making device of traditional Chinese medicine particle quantitative preparation equipment. The device comprises a film storage mechanism, a first plastic film part, a plastic film core, a second plastic film part, a side sealing mechanism, a film driving mechanism, a bottom sealing mechanism and a clipping mechanism, wherein the film storage mechanism is used for storing a bag making film; the side sealing mechanism is used for sealing of side edges of the bag making film; the bottom sealing mechanism is used for sealing a bottom edge of the bagmaking film; and the clipping mechanism is used for clipping a medicine bag with a preset length. When the device disclosed by the invention is used, the upper opening is kept open when the made medicine bag and the bag making film are clipped; and in subsequent medicine preparation work, traditional Chinese medicine particles can directly fall into the open medicine bag from a medicine bottle, and no extra traditional Chinese medicine particle guide part is needed, so that medicine pollution caused by contact between the different types of traditional Chinese medicine particles and the guidepart during medicine preparation can be avoided.

The invention discloses a preparation method and application of a copper metal organic framework compound. The preparation method comprises the steps of: 1) mixing copper nitrate with 2, 5-bis(3', 5'-dicarboxyphenyl)-benzoic acid, then adding a solvent and performing stirring, then adding fluoroboric acid and performing stirring to obtain a mixed solution A; 2) placing a glass bottle with the sealed mixed solution A obtained in step 1) at 85DEG C-95DEG C for reaction for 8-12h to obtain a crystal B; 3) cleaning the crystal B obtained in step 2) with ethanol three times, then soaking the crystal B in ethanol, and finally drying the crystal in an oven, thus obtaining the copper metal organic framework compound. The preparation method provided by the invention is simple and high in yield. Thecompound prepared by the method provided by the invention has good stability to water and good adsorption ability to drug pollutants, and also has certain desorption ability and recycling ability, and therefore has potential application in adsorption of drug residue in environmental water.

The present invention provides a drug delivery system (1) comprising a drug delivery device (2, 3) carrying at least one reservoir (40a, 40b), and a needle unit (4) being attachable to the drug delivery device (2, 3) in axial extension thereof and adapted to establish a flow way between the at least one reservoir (40a, 40b) and a drug delivery site. The needle unit (4) comprises a needle structure (11) comprising a front needle portion (12) for entering the drug delivery site, and at least one back needle portion (13a, 13b) for insertion into the at least one reservoir (40a, 40b), and a needle shield (20). The needle shield (20) and the needle structure (11) are capable of undergoing relative axial motion between an accommodating relative position in which the needle structure (11) is completely accommodated within the needle shield (20) and a protruding relative position in which the front needle portion (12) protrudes from the needle shield (20), the needle shield (20) and the needle structure (11) being biased towards the accommodating relative position by a first bias force. When the needle unit (4) is attached to the drug delivery device (2, 3) the needle structure (11) and the at least one reservoir (40a, 40b) are capable of undergoing relative axial motion between a disconnected relative position in which the at least one back needle portion (13a, 13b) is spaced apart from the at least one reservoir (40a, 40b), and a connected relative position in which the at least one back needle portion (13a, 13b) and the at least one reservoir (40a, 40b) are fluidly connected, the needle structure (11) and the at least one reservoir (40a, 40b) being biased towards the disconnected relative position by a second bias force which is greater than the first bias force.

The invention discloses a preparation method of a copper complex and application thereof. The preparation method comprises the following steps: 1) mixing copper chloride dehydrate with 1,4-di-(triazole-1-yl) terephthalic acid, and adding the mixture into a solvent to be uniformly stirred to obtain a mixed solution A; and then adding nitric acid to stir the solution to obtain a mixed solution B; 2)in a sealing condition, putting the mixed solution B at 110-130 DEG C to react for 10-14 h to obtain crystals C; and 3) cleaning the crystals C with ethanol for three times, then putting the crystalsC in methanol to be soaked for 2 days, then putting the crystals C in dichloromethane to be soaked for 1 day, and finally putting the crystals C in an oven to be dried to obtain the copper complex. The method disclosed by the invention is simple in synthesis and high in yield. The copper complex has high adsorption efficiency on diclofenac sodium and still has good desorption ability and cyclic utilization ability after adsorbing drug pollutants, so that the copper complex has a potential application in adsorbing drug pollutants in a water environment.

The invention discloses a medicine taking device for a pharmacy of western medicines. The medicine taking device comprises a medicine storage box, a detachable sealing cover is assembled in a medicine inlet formed in the top end of the medicine storage box, a supporting rod is assembled in the center of the top end of an inner cavity of the medicine storage box, a limiting plate is assembled at the bottom end of the supporting rod, a shell is assembled at the bottom end of the medicine storage box, a storage box is arranged at the bottom end of an inner cavity of the shell, a blocking column is fixedly connected to the center of the inner cavity of the shell through a fixing rod, one end of a medicine storage cylinder capable of moving up and down is assembled at the top end of the blocking column, the other end of the medicine storage cylinder penetrates through the shell and the medicine storage box and is located at the lower end of a limiting plate, the medicine storage cylinder is locked through a fixing mechanism, and the fixing mechanism is located at the top end of the inner cavity of the shell. The medicine taking device can be used for taking granular medicines to achieve the purpose of quantitative medicine taking, is convenient to use, reduces the working difficulty of nursing personnel and avoids medicine pollution.

A robotic system and a vented vial adapter are presented herein, the robotic system configured to compound and prepare a drug including a harmless drug. The robot system comprises a laminar flow cabinet; and at least one robotic arm. The vented vial adapter is designed to connect a vial to another component of the drug transfer system. The adapter includes a hydrophobic filter that prevents the passage of liquid while allowing air to pass through the hydrophobic filter, and an air vent to the atmosphere. The vent hole is positioned above the filter, thereby equalizing the internal pressure while preventing the drug from contaminating the atmosphere.

The invention provides a container for keeping easily oxidized mixed content objects. The container for keeping the easily oxidized mixed content objects comprises a rigid container. The rigid container internally comprises a storage cavity, the storage cavity is divided into a plurality of independent storage cavities, the bottom end of each independent storage cavity is provided with a multi-stage extrusion device, the top end of each independent storage cavity is provided with a top end single way valve body, the content objects in each independent storage cavity is squeezed into a flexiblemixing cavity by the multi-stage extrusion device through the top end single way valve body; the flexible mixing cavity is internally provided with a flexible mixing bag, the bottom end of the flexible mixing bag is provided with a plurality of flexible singe way channels, and the flexible singe way channels are connected with the top end single way valve bodies, the top end of the flexible mixing bag is connected with an extraction device through a single-way duct, the extraction device is arranged in a use cavity. According to the container for keeping the easily oxidized mixed content objects, separation and multiple mixing of the content objects firstly avoid drug is not take effect over time after mixing, then solve the problem that repeated air contact with mixed drug and consequently drug contamination is carried out and the drug cannot be used, the drug use time is prolonged, and the hygiene is guaranteed.

The invention relates to a skin patch for transdermal iontophoresis drug delivery. Specifically, the skin patch includes a top-down laminated structural layer. The structural layer includes a backinglayer, a bonding layer, an electrode layer, a gel layer and a protective layer (peeling layer), the bonding layer is used to bond the backing layer and the electrode layer, the electrode layer includes N mutually independent electrode films, the gel layer contains active ingredients to be permeated into skin. And the skin patch includes M conductive caps which are distributed on the mutually independent electrode films, and the conductive caps are used to electrically connect a power supply with the electrode films, wherein M and N are positive integers greater than or equal to 2. The skin patch can be quickly connected with an ion electricity generating device, the use and operation are convenient, the possibility of drug contamination in a whole process does not exist, and industrialization can be conveniently achieved.

The invention discloses a vibrio alginolyticus phage and application thereof. The preservation number of the Vibrio alginolyticus phage vB_ValS_R12Z is ​​GDMCC No: 61738‑B1. The Vibrio alginolyticus phage vB_ValS_R12Z provided by the present invention has the characteristics of a wide cleavage spectrum and a short incubation period, can lyse various Vibrio alginolyticus and Vibrio Owensii 3186, and the incubation period is 10 minutes, and can quickly and effectively kill and prevent corresponding Vibrio disease. In addition, no virulence factor genes and drug resistance genes were detected in the phage genome, indicating that the phage will not enhance the host's toxicity intensity, will not cause drug resistance pollution of the surrounding water environment, and has high safety and environmental friendliness. The Vibrio alginolyticus phage vB_ValS_R12Z can be completely used in the prevention and control of Vibrio alginolyticus diseases in aquatic products.

The invention discloses a high-efficiency sustained-release agricultural chemical and a production process thereof. The agricultural chemical comprises an effective active core layer, a sandwich filmcoating layer and a bio-release permeable membrane layer from the inside to the outside. The effective active core layer is prepared from following raw materials by mass: an agricultural chemical active ingredient, humic acid, auxiliaries, diatomite, a dispersant and cellulose. The sandwich film coating layer is prepared from deionized water, sodium alginate, ethyl cellulose, polyvinyl alcohol andglycerin. The bio-release permeable membrane layer is prepared from cellulose acetate fibers, shrimp shell powder, argy wormwood leaf powder, polyacrylamide, mineral oil, polyhydroxyalkanoate and sodium dodecylbenzenesulfonate. The effective active core layer is prepared by mixing and granulation, the sandwich film coating layer is prepared by spraying, coating and curing, and a product covered with the sandwich film coating layer is subjected to immersion, curing and shaping to prepare a finished product. The prepared product has good sustained-release effects, can resist erosion and erosioncaused by water, and can avoid drug contamination of water bodies and plant fruits.