672 results about "Pain relief" patented technology

The invention discloses percutaneous nerve field vagus nerve stimulation diagnosis and treatment equipment and a diagnosis and treatment method thereof, and particularly relates to the technical field of neuromedicine, intelligent medical equipment and multi-mode physical therapy. The equipment comprises a neural signal acquisition module, a nerve positioning module, a data processing and analysis module, a treatment execution module and a diagnosis result output module; the system is further provided with a battery power management module, a self-adaptive closed-loop cloud platform and a wearable fixing device, by collecting bioelectricity signals, light absorptivity and temperature data of an ear nerve area, ear target cranial nerve branches are positioned, a dynamic diagnosis map is constructed, and a diagnosis result and personalized treatment parameters are generated. Electric pulse, near-infrared light and local thermal therapy multi-mode collaborative stimulation is adopted for treatment, and parameters are monitored and adjusted in real time through a cloud platform. According to the invention, accurate diagnosis and personalized treatment can be realized, the medical efficiency and the treatment effect are improved, and an effective means is provided for nerve disease diagnosis and treatment and pain relief.

The present invention relates to novel compounds that inhibit Nav1.8 sodium channels, methods of making, and methods of using thereof. The present disclosure is further directed to administering the disclosed compounds as therapeutic solutions for acute, chronic, and neuropathic pain to a subject in need thereof.

Methods and systems are provided for treating chronic pain using spinal cord stimulation in combination with a neural recording device that records electrical signals from neural activity associated with chronic pain. Machine learning computational models are used to classify patterns of neural activity associated with various pain states and pain relief. Neural signatures of “chronic pain” and “pain relief” are used to assist with spinal cord stimulation programming to determine therapeutic stimulation parameters that achieve analgesia without paresthesia, the minimum stimulation amplitude needed for effective therapy, and to predict whether spinal cord stimulation is likely to be effective in relieving pain. A closed-loop therapy system is provided comprising a spinal cord stimulator that records brain electrical signals from neural activity associated with pain and automatically adjusts spinal cord stimulator settings to deliver electrical stimulation to the spinal cord when pre-specified patterns of neural activity associated with pain are detected.

A lotion applicator for applying a lotion or skincare product to hard-to reach portions of the body is disclosed. The lotion applicator includes a handle or elongated rod. The handle includes a jaw-like structure or clamp capable of releasably holding a roll-on lotion or bottle containing lotion, soap, gel, pain relief lotion, personal care product, cleaning agent, cosmetics and the like. The clamp presents a first part and a second part forming a receptacle for holding the roll-on lotion. The length of the handle is adjustable allowing a user of the lotion applicator to reach the entire area of the back of the user and apply the lotion.

An apparatus includes a pair of engaging members to engage a first and second portion of a body toward an upper and lower portion of a neck, and a plurality of assemblies connecting the first engaging member and the second engaging member to maintain a distance between bones of a body portion comprising an area of the neck, wherein the body portion resides between the first and second portions, and wherein each assembly comprises a plurality of rods coupling the first engaging member and the second engaging member, and a coupling tube with a first rod of the plurality of rods secured to a proximal end and a second rod of the plurality of rods secured to a distal end, wherein rotation of the coupling tube adjusts a gap between the first and second rods in the coupling tube to control the distance between the bones of the body portion.

The invention belongs to the technical field of cosmetic efficacy evaluation, and discloses a sunscreen efficacy evaluation method and application thereof, and the method comprises the following steps: building a blank group; establishing a model group; establishing a sample group; performing constant-temperature incubation on the blank group, the model group and the sample group for a first period of time, recording a swimming track, and calculating swimming distance increment and after-sun burning pain relieving efficiency of each group of zebrafish; performing constant-temperature incubation on the blank group, the model group and the sample group for a second duration, recording the tail fin and dorsal fin area of the zebra fish, and calculating the sunburn prevention efficiency; performing constant-temperature incubation on the blank group, the model group and the sample group for a third period of time, recording the head melanin area of the zebra fish, and calculating the anti-sunburn efficiency; and grading the sunscreen effect of the sample. The method disclosed by the invention has the advantages of low cost, short test period, high reproducibility, high visualization degree, intuitive and understandable test result and the like, and can be used for accurately grading the sunscreen effects of chemical sunscreen agents, water-soluble sunscreen cosmetics and raw materials thereof from the whole animal level.

The invention belongs to the technical field of medicine preparation, and relates to PLGA gel used as an injectable long-acting local anesthesia medicine as well as application and a preparation method of the PLGA gel. The PLGA gel comprises the PLGA gel which is loaded with superparamagnetic Fe3O4 particles and a small molecule local anesthetic, namely, levobupivacaine (Levobupi). The PLGA hydrogel containing Fe3O4 and levobupivacaine can be used as an injectable long-acting local anesthesia medicine, and the hydrogel can be changed from liquid to solid after being injected into a living body, so that the release efficiency of the medicine is slowed down, and the local action time of the hydrogel is prolonged. In addition, the hydrogel can undergo a phase change from a solid state to a liquid state under magnetocaloric therapy (MHT), increase pore diameter, promote release of levobupivacaine, and provide enhanced pain relief in vivo. Compared with the prior art, the invention has the beneficial effects of simple synthesis and easy industrialization. The drug release rate is adjusted through the phase change of the hydrogel, super-long-acting analgesia is realized, and the analgesia time is gt; 20 days. The gel can be loaded with various local anesthesia drugs such as L-bupivacaine, and pain management can be carried out on various pain scenes clinically.

The invention relates to a traditional Chinese medicine composition for treating haemorrhoids and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 20-60 parts of sargentgloryvine stem, 15-45 parts of moutan bark, 20-40 parts of dandelion, 20-40 parts of rheum officinale, 20-40 parts of radix paeoniae rubra and 10-30 parts of lithospermum erythrorhizon. The traditional Chinese medicine composition has the effects of cooling blood and detoxifying, promoting blood circulation to remove blood stasis and relieving swelling and pain through combination of all the medicines, can remarkably relieve inflammation and pain of haemorrhoids through test verification, and has the potential of industrial production and popularization.

The invention relates to an intelligent high-voltage pulse electrical stimulation system and a control method, and solves the problems of poor individual suitability, low positioning precision and weak safety in the prior art. The system obtains body surface point cloud through a split scanning module (infrared / TOF), and dynamic mapping of an anatomical structure is achieved in combination with a medical image template library (the error is smaller than 1.2 mm); dynamically adjusting a high-voltage pulse (0-1200V) based on a BMI-impedance model, and adopting an improved KNN algorithm to match a discharge scheme; three-level safety protection is innovated, and dangerous area protection is achieved through impedance sudden change detection, displacement compensation and phase counteracting (electric field attenuation is larger than 99.9%). Clinical verifications show that the positioning precision is + / -0.5 mm, the pain relief rate of obese patients (BMI = 32) is 92%, and the false touch rate is less than 0.01%. Accurate targeting and safe regulation and control are achieved, and the method is suitable for the fields of muscle rehabilitation, pain management and the like.

Devices, systems, software, and methods are provided for treating chronic pain in an individual using deep brain stimulation (DBS). An implantable brain stimulation and neural recording device is used to identify personalized pain biomarkers to automate brain stimulation using adaptive DBS algorithms in response to pain-associated brain states. Methods are also provided for identifying effective personalized brain stimulation sites for an individual through a systematic, multi-site brain mapping trial and tailoring real-time adaptive DBS programs to an individual to provide significant pain relief.

The invention discloses a python oil compound for treating skin burns, scalds and cuts and a preparation method thereof, and relates to the technical field of traditional Chinese medicine. The python oil compound formula is composed of python oil extract, aloe, borneol, jade square gold tablets, psoralea corylifolia, scutellaria baicalensis, rosmarinus officinalis, sophora flavescens extract, cnidium monnieri and glycerol. Appropriate raw materials are weighed in parts by weight, and the python oil compound is obtained through screening, crushing, boiling and cooling. The python oil compound for treating skin burns, scalds and cuts provided by the invention has a reasonable ratio of Chinese medicinal materials, has strong permeability, can promote blood circulation, has obvious analgesic effect, can repair damaged cells, is not easy to leave scars after healing, and has the advantages of simple preparation process and convenient product use.

The invention provides a stem cell composition with a knee joint injury repair function and a preparation method thereof, the stem cell composition comprises mesenchymal stem cells and an anti-NGF antibody, the anti-NGF antibody comprises a heavy chain variable region with an amino acid sequence shown as SEQ ID NO: 1 and a light chain variable region with an amino acid sequence shown as SEQ ID NO: 2; the mesenchymal stem cells are adipose mesenchymal stem cells and are subjected to activation treatment. The activated adipose-derived mesenchymal stem cells are combined with an anti-NGF antibody for use, so that the gonitis repair can be promoted, the expression of inflammatory factors can be inhibited, and the pain symptom can be relieved.

The present invention discloses a circulating cold compress device for orthopedic care for relieving pain, comprising a cold compress bag, wherein the annular groove is provided in the middle of the outer surface of the cold compress bag, the telescopic sealing cloth is movably arranged on the inner side of the annular groove, the inner wall of the cold compress bag is provided with a channel corresponding to the telescopic sealing cloth, a cold compress liquid main box is slidably provided inside the cold compress bag, a control component is installed inside the cold compress liquid main box, a threaded rod is provided on the inner side of the annular groove, the outer surface of the threaded rod is fixedly connected to the telescopic sealing cloth, a deployment component is installed inside the cold compress liquid main box, and a liquid collection and release component is provided inside the cold compress bag, which is beneficial for the cold compress position to be able to be adjusted at any time when the cold compress device is in use, and the cold compress position can be accurately controlled to avoid discomfort to the patient caused by cold compress in the pain-free zone, the cold compress method is convenient to adjust, and the cold compress quality is improved.

An exercise device is disclosed to enable a user to stretch the lower limbs, lower back, hamstrings, gluteal tendons and gluteal fasciae for pain relief. The stretching device includes a padded body rest having back and leg rest sections hingedly connected together and rotatable from an unfolded configuration to a compact folded configuration lying face-to-face. First and second pairs of leg lifting straps are connected to one another by respective cam jam buckles so as to extend between the body rest and cuffs that surround the user's ankles and feet. A pulling force applied to each leg lifting strap causes the user's legs to be raised off the body rest from a horizontal flat position to a vertical upstanding position. Force monitors are located between the pairs of the leg lifting straps and the user's legs to provide a visual indication of the pulling force.

The invention relates to a traditional Chinese medicine composition for treating burns and scalds, which is prepared from spur root and jade grape root according to a certain compatibility, and has the following effects: pain relieving: aching feeling is relieved or even disappears within 15 minutes; convergence: seepage of tissue fluid can be stopped within two hours; bacteriostasis: after the ointment is used, wounds which are just burnt and scalded or fester for several months can be gradually healed, and necrotic tissues can scab and fall off; skin grafting is not needed for burn and scald patients, scar tissue hyperplasia is avoided, and the disability rate of the patients is greatly reduced.

The present invention relates to the technical field of aromatherapy in traditional Chinese medicine, and specifically to an aromatherapy composition for treating peripheral phlebitis through transdermal absorption, and its preparation and application. The aromatherapy composition and its preparation of the present invention are used for transdermal treatment of peripheral superficial phlebitis through aromatherapy in traditional Chinese medicine, and the overall effective rate of 24h treatment is 100%, of which the cure rate is 55%, and the cure rate is 97.5% after 48h. The reduction of phlebitis grade is recorded as grade difference, and the sum of grade differences of 40 patients is 125. The treatment effect of peripheral superficial phlebitis is significantly superior to traditional and commonly used methods. Compared with traditional therapies, it can greatly shorten the treatment time, quickly relieve pain, reduce the incidence of complications, and has stable and reliable efficacy. Patients' compliance, comfort and acceptability during the treatment process are very good.

The present invention is directed to novel compounds that inhibit Nav1.8 sodium channels, methods of making, and methods of using thereof. The present disclosure is further directed to administering the disclosed compounds as therapeutic solutions for chronic pain, primary pain, idiopathic pain, gastrointestinal pain, neuropathic pain, musculoskeletal pain, acute pain, inflammatory pain, cancer-related pain, idiopathic pain, postoperative pain, visceral pain, multiple sclerosis, Summer-Marr-Tuff syndrome, incontinence, pathological cough, or arrhythmia to a subject in need thereof.

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses a compound bear gall pain-relieving gel as well as a preparation method and application thereof. The compound bear gall pain-relieving gel comprises the following components in percentage by mass: 15-25% of a traditional Chinese medicine composition, 2.5-3.5% of a matrix, 7-13% of a humectant, 1-10% of a penetration enhancer and a proper amount of a pH regulator. The invention discloses a compound bear gall pain-relieving gel as well as a preparation method and application thereof. The compound bear gall pain-relieving gel has a remarkable treatment effect on inflammatory pain and can quickly relieve pain and relieve swelling, the gel dosage form is convenient to smear and can directly reach a focus, and a safe, efficient and convenient new choice is provided for treatment of the inflammatory pain.

There is provided a transvenous cryoneurolysis system and method for accessing and targeting neural treatment sites to relieve a variety of clinical indications, including peripheral neuropathy. A neurosome approach is described that includes one or more target nerves to receive selective cryoneurolysis via a target vein. The system performs a variety of freeze-thaw cycles via the target vein to induce a desired axial cryolesion along a target nerve. The target nerves and veins are selected to combine the treatment of the identified neurosome for pain relief in addition to the regenerative properties of cryoneurolysis.

Thermal therapy systems comprising a compression garment that has an inner surface and an outer surface with one or more pockets, each having at least one opening and a circular pouch shape with an interior compartment functionally configured to receive and hold in place a thermal therapy pack over a target anatomical area, for example, the user's waist, a limb, a knee, ankle, elbow, or shoulder. The various embodiments of the present invention have the advantage that they can accommodate one or more hot / cold packs in compartments that can comfortably hold the hot / cold packs in place anywhere around the waist, a knee, ankle, elbow, or shoulder, and simultaneously provide a cloth barrier between the hot / cold packs and the person's skin.

The negative pressure drainage dressing comprises a dressing body, a flexible sealing film used for covering the dressing body to form sealing is arranged on the dressing body, a negative pressure assembly which is communicated with the dressing body and generates negative pressure is arranged on the flexible sealing film, and a notch is formed in the position, at the application wound surface, of the bottom of the dressing body. The dressing has the advantages of avoiding adhesion between the dressing and a wound surface and relieving pain.

The present disclosure provides an electrode lead of an implantable nerve stimulator, the electrode lead configured to be at least partially implanted in a patient's body, the electrode lead comprising a body in an elongated shape, and a plurality of electrode contacts attached to the body, distributed at intervals in a longitudinal direction of the body, and configured to contact a target tissue in the patient's body, the system includes at least one electrode contact configured to deliver electrical stimulation to the target tissue, and a heater configured to heat the at least one electrode contact to deliver thermal stimulation to the target tissue through the at least one electrode contact. The thermal stimulation can block and interfere the transmission of a pain signal to the brain while reducing the nervous excitability by activating a specific neural pathway, so that the pain is more effectively relieved. The comfort of the patient is improved, and the treatment period is shortened.

The invention discloses a wearable pain relieving device which comprises a box body, the box body is provided with a massage mechanism used for massaging the wound of a patient, the box body is further provided with a temperature control applying therapy assembly used for hot compress or cold compress of the wound of the patient, and the temperature control applying therapy assembly can move relative to the box body to adjust the distance between the temperature control applying therapy assembly and the wound of the patient. Fixing belts used for fixing the box body on the body surface of a patient are further arranged on the two sides of the box body; by integrating the hot compress function, the cold compress function and the massage function, multiple effects are organically combined, and the diversified requirements of a patient in the aspects of wound nursing and pain relieving can be met. The temperature-control applying therapy assembly is designed in a detachable mode, replacement and maintenance are convenient, meanwhile, the distance between the temperature-control applying therapy assembly and a wound can be adjusted, and comfort and safety in the using process are guaranteed. The massage mechanism can uniformly and rhythmically massage the periphery of the wound through cooperative work of massage balls, an elastic assembly and a driving assembly, and muscle tension and pain are effectively relieved.

The present invention provides a method to reduce pain using electrical stimulation of peripheral nerves in or near the spine. This approach involves an electrical stimulation device including at least one electrode adapted for insertion within a human body and at least one pulse generator operatively coupled with the at least one electrode, wherein the pulse generator delivers electrical stimulation activating at least one peripheral nerve in or near the spine, such as the dorsal rami and its distal branches (e.g., the medial branch nerves, cluneal nerves), the ventral rami and its distal branches (e.g., sacral nerves, gluteal nerves), and those accessed via the paravertebral space (e.g., peripheral spinal nerves), to produce pain relief.

The invention relates to the technical field of rheumatism immune physical therapy, in particular to a rheumatism immune physical therapy pain relieving device which comprises a supporting plate, one end of the supporting plate is provided with a movable plate, and the end, away from the supporting plate, of the movable plate is provided with multiple sets of fingerstalls; the fixing assembly is used for fixing the fingerstall and comprises a second limiting rod; the massage assembly is arranged in the fingerstall, and the massage assembly comprises an arranged rotating disc; the device has the beneficial effects that through cooperation of a guide block and a first guide groove, a finger sleeve can be arranged on one side of an arc-shaped limiting plate in a sliding mode, during adjustment, a connecting plate is lifted, in the upward moving process of the connecting plate, a second limiting rod is driven by a first limiting rod to move upwards synchronously, and when the second limiting rod is not inserted into a fixing hole any more, the finger sleeve can be arranged on one side of the arc-shaped limiting plate in a sliding mode. The distance between the multiple sets of fingerstalls arranged in a sliding mode can be adjusted, after adjustment is completed, the acting force on the connecting plate is removed, and under the action of a second reset spring, an elastically-arranged connecting rod is inserted into a fixing hole, so that limiting of the fingerstalls is completed.

A treatment brassiere for providing treatment / pain relief for various skin conditions of the inframammary fold. The brassiere includes or accepts an inframammary-fold treatment-device (IMFTD) retainer that, in use, receives an inframammary-fold treatment device. The IMFTD retainer is located very near to, overlying, or partially overlying the inframammary fold of the wearer of the brassiere, so as to position the inframammary-fold treatment device at a location suitable for delivering treatment to the affected area.

Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and / or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.

An adaptive stimulation system optimizes pain relief, pleasure enhancement, and healing through closed-loop physiological effectiveness monitoring. The system comprises a stimulation device, sensors measuring physiological responses indicative of stimulation effectiveness, and a processor implementing real-time adaptive control. The system measures unconscious physiological responses that users cannot voluntarily control and involuntary reactions to objectively assess whether stimulation achieves desired outcomes. Through proxy learning, system sensors correlate with sophisticated clinical measurements via machine learning, enabling clinical-grade optimization using accessible devices. The system continuously explores multidimensional parameter spaces to discover optimal stimulation patterns personalized to individual users, automatically adapting parameters based on measured physiological effectiveness rather than subjective user control or preset patterns. Applications include medical devices, wellness products, and intimate stimulation systems.

A natural supplement is described herein. The supplement includes a therapeutically effective amount of a composition. The composition includes: at least two materials having analgesic activity, at least two materials having anti-inflammatory activity, at least two materials having antioxidant activity, at least two materials having anti-neuralgic activity, at least two materials having blood circulation promotion activity, at least one material having Dihydrotestosterone (DHT) blocking activity, and at least one material having hair thickening activity or hair growth activity. The natural supplement not only provides pain relief from a variety of symptoms, but also promotes hair growth.

The invention discloses chronic ulcer wound repair gel as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The bacterial cellulose has the advantages of good biocompatibility, high water holding and moisturizing capacity, strong mechanical property, good air permeability, low toxicity and the like, so that the bacterial cellulose-based chronic ulcer wound repair gel capable of promoting chronic wound healing is prepared by compounding functional components by utilizing the material advantages of the bacterial cellulose. The gel can bidirectionally adjust the wet balance of the wound surface; a large amount of hydroxyl groups are contained, so that high water retention can be achieved, the ice-cold feeling is achieved, pain is effectively relieved, stimulation to wounds and mucous membranes is relieved, sensitivity of exposed nerves is relieved, and pain is relieved; the photosensitizer in the gel can inhibit bacterial infection through irradiation of near-infrared laser, and the active ingredients can inhibit inflammation diffusion, promote collagen deposition, angiogenesis and the like to promote healing of chronic ulcer wounds.