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284 results about "Pain relief" patented technology

Method and apparatus to maintain distance between bones of a neck for pain relief

An apparatus includes a pair of engaging members to engage a first and second portion of a body toward an upper and lower portion of a neck, and a plurality of assemblies connecting the first engaging member and the second engaging member to maintain a distance between bones of a body portion comprising an area of the neck, wherein the body portion resides between the first and second portions, and wherein each assembly comprises a plurality of rods coupling the first engaging member and the second engaging member, and a coupling tube with a first rod of the plurality of rods secured to a proximal end and a second rod of the plurality of rods secured to a distal end, wherein rotation of the coupling tube adjusts a gap between the first and second rods in the coupling tube to control the distance between the bones of the body portion.
Owner:VOSSOUGHI JAFAR

Traditional Chinese medicine composition for treating haemorrhoids as well as preparation method and application of traditional Chinese medicine composition

The invention relates to a traditional Chinese medicine composition for treating haemorrhoids and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 20-60 parts of sargentgloryvine stem, 15-45 parts of moutan bark, 20-40 parts of dandelion, 20-40 parts of rheum officinale, 20-40 parts of radix paeoniae rubra and 10-30 parts of lithospermum erythrorhizon. The traditional Chinese medicine composition has the effects of cooling blood and detoxifying, promoting blood circulation to remove blood stasis and relieving swelling and pain through combination of all the medicines, can remarkably relieve inflammation and pain of haemorrhoids through test verification, and has the potential of industrial production and popularization.
Owner:HEBEI PING AN HEALTH GRP CO LTD

Traditional Chinese medicine composition for treating burns and scalds

The invention relates to a traditional Chinese medicine composition for treating burns and scalds, which is prepared from spur root and jade grape root according to a certain compatibility, and has the following effects: pain relieving: aching feeling is relieved or even disappears within 15 minutes; convergence: seepage of tissue fluid can be stopped within two hours; bacteriostasis: after the ointment is used, wounds which are just burnt and scalded or fester for several months can be gradually healed, and necrotic tissues can scab and fall off; skin grafting is not needed for burn and scald patients, scar tissue hyperplasia is avoided, and the disability rate of the patients is greatly reduced.
Owner:TENGAN PHARMACEUTICALS (HANGZHOU) CO LTD

Adaptive stimulation device with integrated feedback mechanism and proxy measurement

PCT designated stageWO2026097013A1Machine learningExternal electrodesStimulus patternPhysical medicine and rehabilitation
An adaptive stimulation system optimizes pain relief, pleasure enhancement, and healing through closed-loop physiological effectiveness monitoring. The system comprises a stimulation device, sensors measuring physiological responses indicative of stimulation effectiveness, and a processor implementing real-time adaptive control. The system measures unconscious physiological responses that users cannot voluntarily control and involuntary reactions to objectively assess whether stimulation achieves desired outcomes. Through proxy learning, system sensors correlate with sophisticated clinical measurements via machine learning, enabling clinical-grade optimization using accessible devices. The system continuously explores multidimensional parameter spaces to discover optimal stimulation patterns personalized to individual users, automatically adapting parameters based on measured physiological effectiveness rather than subjective user control or preset patterns. Applications include medical devices, wellness products, and intimate stimulation systems.
Owner:HABERMAN SETH

Organic pain relief and hair growth composition

A natural supplement is described herein. The supplement includes a therapeutically effective amount of a composition. The composition includes: at least two materials having analgesic activity, at least two materials having anti-inflammatory activity, at least two materials having antioxidant activity, at least two materials having anti-neuralgic activity, at least two materials having blood circulation promotion activity, at least one material having Dihydrotestosterone (DHT) blocking activity, and at least one material having hair thickening activity or hair growth activity. The natural supplement not only provides pain relief from a variety of symptoms, but also promotes hair growth.
Owner:THE TAO TALIT CORP

Traditional Chinese medicine application for relieving pain in neck, shoulders, waist and legs and preparation method of traditional Chinese medicine application

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine application for relieving neck-shoulder and lumbocrural pain and a preparation method thereof. The traditional Chinese medicine application is prepared from, by mass, 15-50 g of obscured homalomena rhizome, 15-50 g of cortex illicii, 15-50 g of herba lycopodii, 15-50 g of rhizoma curcumae longae, 15-50 g of rhizoma corydalis, 15-50 g of radix puerariae, 15-50 g of garden balsam stem, 15-50 g of radix saposhnikoviae, 15-50 g of flos carthami, 15-50 g of radix cyathulae, 15-50 g of rhizoma seu radix notopterygii, 15-50 g of radix angelicae pubescentis, 15-50 g of lumbricus, 15-20 g of frankincense, 15-20 g of myrrh and 20-30 g of radix clematidis. Compared with traditional medicine application with a single effect, the traditional Chinese medicine application has the advantages that the pain relieving effect is quicker, the symptom improvement is more thorough, meanwhile, the application range of treating the neck, shoulder, waist and leg pain is expanded, and a patient can operate the traditional Chinese medicine application at home without assistance of professional medical equipment.
Owner:陈海彪

Guizhou buckthorn skin wound healing ointment and preparation method thereof

The application provides a Guizhou Rhamnus skin wound healing ointment and a preparation method thereof, and relates to the technical field of traditional Chinese medicine compositions. The ointment comprises Guizhou Rhamnus concentrated extract and base excipients. The ointment has the functions of promoting skin wound healing, preventing swelling and pain, preventing infection and scar, reducing swelling and pain, removing blood stasis and promoting tissue regeneration, dredging channels and activating collaterals, and healthy skin tissue. The active ingredients of traditional Chinese medicine have the advantages of rapid healing and repair, obvious swelling and pain relief, delicate ointment texture, easy absorption by the skin, high safety, good stability, wide source of raw materials, easy collection, simple preparation process, batch processing, no toxic side effects on the health of production personnel, and no adverse effects on the environment.
Owner:GUIZHOU PROVINCIAL PEOPLES HOSPITAL +1

Vertical carbon dioxide refrigeration unit

1. Name of the product in this design: Vertical carbon dioxide refrigeration unit. 2. Purpose of this design: To relieve pain and swelling by stimulating the skin and subcutaneous blood with low temperature, thereby facilitating a series of biochemical reactions in the human body and achieving sports recovery. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.
Owner:RHEIN LASER TECH CO LTD

A tooth-fixing pain-relieving and inflammation-clearing traditional Chinese medicine composition

PendingCN122424247ATissue repairBurning Pain
The application discloses a kind of solid teeth pain-relieving and inflammation-clearing traditional Chinese medicine composition, it is related to traditional Chinese medicine product technical field.The composition is composed of gypsum, raw rehmannia, coptis, talc, ocher, radix cyathulae and salvia miltiorrhiza seven raw medicinal materials, wherein gypsum, raw rehmannia are monarch drug, clear and purge stomach fire, cool blood and nourish yin;Coptis, talc are ministerial drug, clear heat and dry dampness, lead heat down;Ocher, radix cyathulae are auxiliary drug, heavy town counteract, lead fire down;Salvia miltiorrhiza is servant drug, promote blood circulation and remove blood stasis, promote tissue repair.Modern pharmacological research shows that each drug of the present party has the effects of anti-inflammatory, analgesic, antibacterial, improving microcirculation and protecting periodontal tissue etc.Clinical observation shows that the pain of most patients caused by stomach fire attacking upward, gum redness and swelling, burning pain, bleeding is significantly reduced after taking 1-2 doses, redness and swelling gradually subside.Compared with existing Chinese patent medicines, the present application is simple in prescription, low in cost, has the dual effects of rapid pain relief and long-term tooth fixation, and is especially suitable for patients with recurrent toothache and early periodontitis.
Owner:周桂芳 +1

Dysmenorrhea relief massage patch

1. The name of the design product: pain relief massage paste. 2. The use of the design product: for daily life massage. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective drawing.
Owner:GUANGZHOU ANLU TECHNOLOGY CO LTD

High elasticity hyaluronan compositions and methods of use thereof

The present invention provides methods for alleviating pain and discomfort associated with a dry eye condition; methods for alleviating pain and discomfort while minimizing at least one skin imperfection; and methods for alleviating pain and discomfort while facilitating wound healing. The methods involve administering to a subject in need thereof a composition comprising hyaluronan with high elasticity.
Owner:MATRIX BIOLOGY INSTITUTE

Triple therapy medicine composition for treating chronic knee joint injury and preparation method and injection product thereof

The invention provides a triple therapy medicine composition for treating chronic knee joint injury and a preparation method and an injection product thereof, and belongs to the technical field of medical biology. The invention provides a triple therapy pharmaceutical composition for treating knee joint injury. The pharmaceutical composition consists of the following components in parts by volume: 2-5 parts of platelet-rich plasma, 2-5 parts of mesenchymal stem cells and 2-5 parts of exosomes. The platelet-rich plasma, the mesenchymal stem cells and the exosome promote each other, so that the effects of relieving pain and promoting cartilage repair are superimposed and strengthened, the symptoms and functions are improved, the disease progression is delayed or partially reversed, and a relatively good effect on treating knee joint injury is achieved.
Owner:中海峡(福建)细胞生物科技有限公司

Vaginal delivery pain relieving massage chair device

The utility model relates to the technical field of medical instruments, in particular to a vaginal delivery pain relieving massage chair device which comprises a massage chair body, and four fixing columns are fixedly connected to one side of the massage chair body. The massage chair device has the advantages that the massage chair device is provided with the protection assembly, the massage chair device can be protected through the protection assembly when a user uses the massage chair device, and the problem that the massage chair device does not have measures for protecting the user, so that the user is prone to falling off when using the massage chair device to move is solved; the safety performance of the massage chair device is improved, a relaxing assembly is further arranged, and a flat plate can be placed through the relaxing assembly, so that a user can watch the flat plate to relax mood or watch relaxation and breathing skill guidance in the delivery process of a puerpera when using the massage chair device; the massage chair device solves the problem that the mood of a user is nervous due to the fact that the user is not interesting when using the massage chair device, and the practical performance of the massage chair device can be improved.
Owner:THE 923RD HOSPITAL OF THE CHINESE PEOPLES LIBERATION ARMY JOINT LOGISTICS SUPPORT FORCE

Freeze-dried injectable formulation comprising beta-nicotinamide mononucleotide, injectable composition comprising same, and preparation method therefor

The present invention relates to a freeze-dried injectable formulation comprising beta-nicotinamide mononucleotide, an injectable composition comprising same, and a preparation method therefor. In addition, the present invention relates to a pain relief injectable composition and a preparation method therefor, the composition comprising beta-nicotinamide mononucleotide and hyaluronidase, and having a pH of greater than 4 and 8 or less.
Owner:KANG SIHA

Delivery pain relieving rehabilitation training software based on extended reality technology

PendingCN121905428AReduce pain during pregnancy and childbirthImprove the effectiveness of interventionInput/output for user-computer interactionPhysical therapies and activitiesPersonalizationSimulation
The invention provides delivery pain relieving rehabilitation training software based on an expanded reality technology, relates to the technical field of virtual reality education, and relates to a server side, a display side and a control side. An intervention strategy is stored through a scheme storage module of the server side; performing attention intervention on the target object through a plurality of execution modules of the display end; the control end comprises a training monitoring module; the training monitoring module comprises a state obtaining sub-module used for obtaining the current state of the target object; the strategy matching submodule is used for matching a corresponding recommendation intervention strategy from the scheme storage module based on the current state; the personalized strategy generation sub-module is used for generating an auxiliary intervention strategy according to the recommended intervention strategy and / or an adjustment instruction of the user; the auxiliary intervention strategy comprises an execution sequence of intervention means; and the execution sub-module is used for executing an auxiliary intervention strategy to assist in relieving pains of the target object in the pregnant and birth period and improve intervention efficiency and accuracy of the pains in the pregnant and birth period.
Owner:SHANGHAI TENTH PEOPLES HOSPITAL +1

Acupuncture pain relief device

Provided is an acupuncture pain relief device, which comprises at least one conductive acupuncture needle and at least one capacitor; and the conductive acupuncture needle is conductively connected with the capacitor, so that free electrons can flow through the conductive acupuncture needle and be stored in the capacitor. This acupuncture pain relief device utilizes the characteristic that the capacitance of the capacitor is much larger than that of the human body of the acupuncturest, greatly improving the acupuncture analgesic effect; it uses the capacitance of the capacitor to replace the capacitance of the human body of the acupuncturest, greatly reducing the workload of the acupuncturest. Since this new acupuncture pain relief device can be inserted into the patient's acupoints for pain relief without time limitation, it can be used not only in hospital operations but also widely applied to alleviate the pain of patients, and has great market potential.
Owner:WANG JIANAN

A smart high-voltage pulse electrical stimulation system and its control method

This invention relates to an intelligent high-voltage pulsed electrical stimulation system and control method, addressing the problems of poor individual adaptability, low positioning accuracy, and weak safety in existing technologies. The system acquires body surface point clouds through a split scanning module (infrared / TOF) and achieves dynamic mapping of anatomical structures (error <1.2mm) by combining a medical image template library. It dynamically adjusts the high-voltage pulse (0-1200V) based on a BMI-impedance model and employs an improved KNN algorithm to match the discharge scheme. An innovative three-level safety protection system is implemented, using impedance mutation detection, displacement compensation, and phase cancellation (electric field attenuation >99.9%) to protect dangerous areas. Clinical validation shows a positioning accuracy of ±0.5mm, a pain relief rate of 92% in obese patients (BMI=32), and a false trigger rate of <0.01%. This invention achieves precise targeting and safe control, and is applicable to fields such as muscle rehabilitation and pain management.
Owner:银富强

Plaster for relieving shoulder, neck, lumbar vertebra, arthralgia and traumatic injury, relaxing tendons, activating collaterals and relieving pain and breast and preparation method thereof

PendingCN121337943AAntipyreticHydroxy compound active ingredientsPoulticeLycopodium clavatum
The invention provides a tendon-relaxing, collateral-activating and pain-relieving breast plaster for shoulder, neck, lumbar vertebra, arthralgia and traumatic injury. The plaster is prepared from the following raw materials in parts by weight: 22-35 parts of frankincense, 41-55 parts of mirabilite, 26-40 parts of ligusticum wallichii, 31-40 parts of lycopodium clavatum, 5-20 parts of dragon's blood, 5-20 parts of pseudo-ginseng, 10-25 parts of radix clematidis, 40-55 parts of pawpaw, 35-45 parts of radix angelicae pubescentis, 40-50 parts of pericarpium zanthoxyli, 40-50 parts of ginger, 30-35 parts of rhizoma drynariae, 42-47 parts of radix aconiti kusnezoffii, 43-48 parts of radix aconiti, 45-50 parts of asarum, 40-50 parts of 20 to 30 parts of chamomile, 10 to 25 parts of menthol oil, 10 to 25 parts of camphor oil, 15 to 25 parts of lavender essential oil and 10 to 25 parts of wintergreen oil; 15-25 parts of radix saposhnikoviae oil, 15-25 parts of garden balsam stem oil and 15-30 parts of safflower oil. The ointment has special effects on shoulder, neck and lumbar vertebra, arthralgia, traumatic injury, tendon relaxing, collateral activating and pain relieving; and the traditional Chinese medicine composition has the effect of treating both symptoms and root causes without relapse and side effects.
Owner:GUANGDONG ZESHAN BIOTECHNOLOGY CO LTD

Trocar for bone perforation during lateral approach to the intervertebral disc

UndeterminedKZ12689UNeurosurgeryVertebral bone
This utility model relates to medicine and can be used in neurosurgery. It is used as a means of accessing the intervertebral disc between the 5th lumbar and 1st sacral vertebrae at a 90-degree angle for laser vaporization. The utility model achieves the following technical results: 1. A minimally invasive, minimally invasive approach to the intervertebral disc at the L5-S1 level. 2. Allows to improve the effectiveness of treatment and achieve maximum pain relief in polysegmental lesions of intervertebral discs 3. Prior to this utility model, attempts were made to perform laser vaporization of the disc at the L5-S1 vertebral body level from anatomically inconvenient locations, which was accompanied by a long time interval, prolonged pain for the patient, the end of the electrode was not in the center of the nucleus pulposus, sometimes even on the cortical layer of the vertebral bodies, as a result of which the maximum effect of vaporization was not obtained, or aseptic inflammation of the bone tissue of the vertebrae was obtained. This utility model eliminates the above-mentioned issues, reducing vaporization time. The essence of this utility model is that, using this trocar and drilling stylet, we provide direct access to the L5-S1 intervertebral disc. Laser vaporization of this disc has not previously been performed due to its anatomical limitations.
Owner:LI KONSTANTIN IUREVICH

A chronic ulcer wound repair gel and methods of making and using same

The application discloses a chronic ulcer wound repairing gel and a preparation method and application thereof, and belongs to the technical field of medical materials. Since bacterial cellulose has the advantages of good biocompatibility, high water retention and moisturizing capacity, strong mechanical property, good air permeability, low toxicity and the like, the bacterial cellulose is used to prepare the bacterial cellulose-based chronic ulcer wound repairing gel capable of promoting chronic wound healing by compounding functional components. The gel can bidirectionally regulate the wet balance of a wound surface; contains a large amount of hydroxyl groups, can highly retain water, has an ice-cool feeling, effectively relieves pain, simultaneously reduces irritation to a wound and a mucous membrane, reduces the sensitivity of exposed nerves, and reduces pain; the photosensitizer in the gel can inhibit bacterial infection by irradiation of near-infrared laser; active components can inhibit inflammatory diffusion, promote collagen deposition and angiogenesis, and the like, so as to promote the healing of a chronic ulcer wound surface.
Owner:SHAN DONG NAMEIDE BIOTECHNOLOGY CO LTD

Packaging box (Miaodang-white box-far infrared blood circulation and pain relief patch)

ActiveCN309874870SFar infraredPain relief
1. The name of the design product: packaging box (Miaodang-white box-far infrared blood circulation and pain relief patch). 2. The use of the design product: for packaging products. 3. The design points of the design product: in the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: design 1 front view. 5. The design for which protection is sought includes color. 6. Design 1 is designated as the basic design.
Owner:ANHUI MIAO DE TANG PHARMA CO LTD

Tracheal cannula end balloon and preparation method thereof and tracheal cannula

The application relates to the field of medical devices, in particular to a tracheal cannula end balloon, a preparation method thereof and a tracheal cannula. The tracheal cannula end balloon comprises a balloon body and a double-layer structure arranged on the surface of the balloon body, and the double-layer structure comprises a first nanofiber membrane and a second nanofiber membrane; the first nanofiber membrane comprises a first matrix material and paclitaxel, and the first matrix material comprises polyethylene glycol and polycaprolactone; the second nanofiber membrane comprises a second matrix material and ropivacaine, and the second matrix material comprises polyethylene glycol and polyvinylpyrrolidone. In the application, the double-layer structure design realizes layered release of the drugs, the outer-layer drugs rapidly relieve pain and inflammation, and the inner-layer drugs continuously inhibit cell proliferation, so that the problems caused by the tracheal cannula end balloon are comprehensively solved.
Owner:THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +1

Systems and methods related to the treatment of back pain

ActiveUS12589245B2Spinal electrodesExternal electrodesBACK DISCOMFORTBack pain
The present invention reduces pain and improves function long-term in persons with back pain using electrical stimulation in the back. This approach involves an electrical stimulation device including at least one electrode adapted for insertion within an animal body with back pain and at least one pulse generator operatively coupled with the at least one electrode, wherein the pulse generator delivers electrical stimulation activating at least a nerve innervating at least a paraspinal muscle in a back of the animal body for pain relief.
Owner:SPR THERAPEUTICS

A mouth liquid for treating oral ulcer and a preparation method thereof

This invention relates to a mouthwash for treating oral ulcers and its preparation method. The mouthwash comprises the following components in the indicated weight ratios: 100 parts deionized water, containing 5-35 parts sodium chloride, 1-10 parts sodium bicarbonate, 0.1-1 parts borneol, 0.1-1 parts peppermint oil, 1-5 parts vitamin E, and 1-5 parts vitamin B12. First, all the above materials (excluding deionized water) are mixed in the indicated weight ratio and ground into a fine powder finer than 400 mesh. Then, peppermint oil is sprayed onto the powder mixture and stirred evenly to obtain the prepared mouthwash powder. The powder is then packaged and sealed. To use, the mouthwash powder is poured into a bottle containing the corresponding weight of deionized water and shaken until fully dissolved before use. This mouthwash has significant effects in treating oral ulcers, providing timely pain relief, accelerating ulcer healing, and shortening the course of the disease.
Owner:SHULIANXIN (CHENGDU) NETWORK INFORMATION TECH CO LTD

Disposable postoperative local infiltration anesthesia analgesia system

A disposable postoperative local infiltration anesthesia analgesia system comprises an anesthesia catheter, a guide wire, a lacerable trocar, an injector and an infusion pump, the anesthesia catheter can be sleeved with the lacerable trocar in a matched mode, the guide wire can be sleeved with the anesthesia catheter in a matched mode, a plurality of micropores are formed in the side wall of one end of the anesthesia catheter, and the infusion pump is connected with the guide wire. The micropores are evenly distributed in the circumferential direction of the anesthesia catheter, the other end of the anesthesia catheter is connected with a first connector tube and a second connector tube, a connector of an infusion pump can be in butt joint with the first branch connector tube or the second connector tube, and an injector can be in butt joint with the first branch connector tube or the second connector tube. The anesthesia catheter can be placed into a pain part of a patient through the guide wire and the tearable trocar, wound infiltration is continuously carried out through anesthetic, pain can be accurately, directly and intensively relieved, the using amount of the anesthetic is reduced, the anesthetic is small in side effect or free of side effect, and the anesthesia catheter is convenient to use. Various severe side effect risks caused by opioid abuse can be effectively avoided.
Owner:ZHENGZHOU DIALL MEDICAL TECH CO LTD

Pain relief system based on brain neural oscillation regulation

ActiveCN116327217Breduce the effecteasy to operateElectrotherapySensorsClinical painNeural oscillation
The application provides an analgesia system based on brain nerve oscillation regulation, relates to the technical field of pain regulation, and first establishes a brain signal standardization information base of healthy people; for each pain patient, the brain nerve signal index of the pain patient is compared with a standard normal range obtained from the brain signal standardization information base of healthy people to determine abnormal electroencephalogram nerve indexes of each pain patient; then, according to the pain specificity of each pain patient, the correlation between the behavior indexes and the abnormal electroencephalogram nerve indexes of the pain patient is analyzed to determine potential regulation target points; the regulation target points to be intervened and regulation modes are selected from the potential regulation target points; different regulation modes are selected according to actual requirements to regulate the pain of the pain patient; and then, the pain regulation effect is evaluated, so that the effect of relieving pain is achieved, the analgesia system has the characteristics of safety, economy and easy operation, and is expected to be applied to the treatment of clinical pain.
Owner:SHENZHEN UNIV

Traditional Chinese medicine combined powder for rapidly treating various burns and scalds

The invention discloses traditional Chinese medicine combined powder for rapidly treating various burns and scalds, and relates to the technical field of traditional Chinese medicine formulas. Traditional Chinese medicine combined powder for rapidly treating various burns and scalds is characterized in that the active ingredients of the powder comprise 6-10 parts by weight of polygonum cuspidatum, 3-9 parts by weight of coptis chinensis, 4-10 parts by weight of paris polyphylla, 6-12 parts by weight of rhizoma bletillae, 15-30 parts by weight of calcined dens draconis, 3-9 parts by weight of spar and 0.1-0.3 part by weight of pearl. The combined medicine powder has the effects of clearing away heat and toxic materials, promoting tissue regeneration, relieving pain, promoting wound repair and enhancing local microcirculation of the wound, the medicine powder generally needs to be combined with sesame oil for use, the core components of the medicine powder, namely polygonum cuspidatum and coptis chinensis, synergistically exert broad-spectrum antibacterial and antioxidant effects, and paris polyphylla and rhizoma bletillae enhance the barrier function of the wound; the calcined dens draconis and the kyanite promote activation of a calcium ion channel, and the pearl can regulate and control ordered deposition of collagen and reduce scar hyperplasia.
Owner:汤学庚

Arginine ibuprofen biphasic sustained release preparation and preparation method thereof

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an arginine ibuprofen biphasic sustained release preparation and a preparation method thereof. Through a two-phase system of quick-release particles and slow-release particles, the problems that a traditional preparation takes effect slowly, is short in medicine effect and poor in taste are solved. Wherein the quick-release granules are prepared by mixing and granulating ibuprofen arginine, a filling agent, an adhesive and a natural flavoring agent, so that the effective blood concentration can be ensured to be reached within 15 minutes after the medicine is orally taken so as to quickly relieve pain, and the bad flavor of the medicine can be synchronously covered; the sustained-release granules are based on an ibuprofen arginine drug-loading core, the outer layer of the sustained-release granules is coated with a sustained-release film formed by a sustained-release agent and a plasticizer, and the effective blood concentration can be stably maintained for 6-8 hours, so that the medicine taking frequency is reduced, the sustained-release granules only need to be taken for 1-2 times every day, the medication compliance of a patient is greatly improved, and the sustained-release granules are suitable for clinical application. The traditional Chinese medicine composition is especially suitable for clinical scenes needing long-term or repeated analgesia such as chronic arthritis and postoperative pain, has excellent safety and practicability, and has a wide market application prospect.
Owner:HEBEI RENHE YIKANG PHARMA +1

Sprayable double-network hydrogel microsphere adhesive as well as preparation method and application thereof

The invention belongs to the technical field of biological medicine, and particularly discloses a sprayable double-network hydrogel microsphere adhesive and a preparation method and application thereof.The preparation method comprises the following steps that liquid paraffin, sorbitan monooleate and polyoxyethylene sorbitan monolaurate serve as oil phases, and an emulsion is formed; fully mixing the emulsion with petroleum ether, centrifugally separating gel microspheres, freeze-drying, and storing in a dark place; preparing a ropivacaine liposome; and adding ultrapure water into the lipid membrane to obtain a primary liposome suspension, adsorbing the liposome by using the hydrogel microspheres, and collecting the obtained dual-network hydrogel microspheres. According to the sprayable double-network hydrogel microsphere adhesive as well as the preparation method and the application thereof, prepared hydrogel microspheres can quickly and consistently cover irregular wounds, and liposome loaded with ropivacaine provides continuous analgesic release, so that the painful wound healing effect is improved. By simultaneously solving the problems of maintaining continuous adhesion and prolonging pain relief in blood-saturated wounds.
Owner:ZHEJIANG CANCER HOSPITAL +1