This invention discloses a topical Chinese
medicine preparation for treating erosive tinea pedis and its preparation method, belonging to the technical field of topical Chinese
medicine preparations. The preparation consists of 15-25 parts clove, 10-20 parts
alum, 20-30 parts
Polygonum cuspidatum, and 10-18 parts
Psoralea corylifolia, and is prepared into a spray using a 45% low-
alcohol countercurrent extraction process. This invention achieves synergistic effects through a three-stage targeting mechanism:
eugenol inhibits fungal CYP51A1
enzyme, blocking
ergosterol synthesis (targeted enrichment rate 62.1%),
resveratrol inhibits the NF-κB pathway, reducing
inflammatory response, and
psoralen activates the PI3K / AKT pathway, promoting epidermal repair (
repair rate 69.2%). The
alcohol concentration of the preparation is reduced to 45%, eliminating
irritation to broken wounds. A
single application takes only 1 minute, and a 7-
day treatment course has a
clinical efficacy rate of 84.7%, saving 320 yuan per person compared to traditional methods. This invention overcomes the shortcomings of existing drugs for treating erosive tinea pedis, such as strong
irritation, cumbersome operation, and limited
efficacy, and fills the gap in the category of specialized preparations, with significant
social benefits and market prospects.