14 results about "Substantia nigra" patented technology

The invention discloses a system for intelligently and automatically identifying and analyzing brain nigra high echo based on a transcranial ultrasonic image to assist in diagnosing Parkinson's disease, and relates to the technical field of image identification. Comprising an ultrasonic image data collection and preprocessing module, a deep learning model construction and training module, a nigra region accurate identification and segmentation module, a nigra region area measurement and statistical analysis module and a diagnosis result verification and visual output module. According to the method, an intelligent automatic identification model based on deep learning is constructed, and model optimization is carried out by using a large amount of manually labeled Parkinson's disease and health contrast ultrasonic image data, so that efficient identification segmentation and area measurement of a nigra region in a transcranial ultrasonic image are realized; and meanwhile, the performance of the model is comprehensively evaluated by using indexes of sensitivity, specificity and accuracy, so that the accuracy of an output result is ensured.

The invention belongs to the technical field of medicines, and discloses application of poliumoside to prevention and treatment of Parkinson's disease. Specifically, the invention discloses application of poliumoside as a compound shown in a formula (I) in the aspect of preventing and treating Parkinson's disease. Pharmacological experiments prove that after 14 days of administration of the poliumoside, the impairment of motor coordination function caused by MPTP-induced Parkinson's disease can be obviously improved, the reduction of the expression level of brain nigra tyrosine hydroxylase caused by MPTP is improved, and the result shows that the poliumoside has obvious pharmacological activity for preventing and treating Parkinson's disease. Therefore, poliumoside can be used for preparing the medicine for preventing and treating Parkinson's disease, and has high clinical application value and development prospect.

The application discloses a device and method for detecting mouse motion learning behavior, and belongs to the field of animal behavior detection. The device comprises a mouse motion runway, a dark box at the terminal of the runway, and a camera for recording the motion process of the mouse. The runway is provided with a plurality of replaceable metal rods in the transverse direction. The metal rods are composed of any one or both of white metal rods and black metal rods. The runway composed of the black metal rods and the white metal rods is provided with any one of the metal rods for electrification, and the electrified metal rods are discontinuously arranged. The mouse is shocked by stepping on the electrified metal rods. The method of the application replaces the metal rods to form different runways, trains the mouse to reach the dark box through the different runways, and obtains the motion learning behavior ability of the mouse at different stages. The process of motion learning is simulated through programmed training. The role of the brain regions in the process of motion learning behavior is determined by regulating the regions of the substantia nigra or the striatum corresponding to the motion learning.

The invention provides a traditional Chinese medicine composition for treating Parkinson's depression and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-10 parts of radix acanthopanacis semticosi and 1-10 parts of bulbus lilii. The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: taking the acanthopanax and the lily, adding water to soak, heating, refluxing and extracting, and combining filtrate to obtain the traditional Chinese medicine composition. Animal experiments find that the acanthopanax-lily traditional Chinese medicine composition has a good treatment effect on Parkinson depression for the first time, and can remarkably improve dyskinesia and depression symptoms, regulate neurotransmitter disorder, relieve damage to nigra and hippocampal neurons and reduce the level of inflammatory factors in serum. After being taken for a long time, the traditional Chinese medicine composition disclosed by the invention can improve depression and life quality, slow down the progress of Parkinson disease and reduce the use of Parkinson drugs.

The application provides application of a hydroxy pentylbenzoic acid double ester compound L-NRB in treatment of Parkinson's disease. Animal model test proves that L-NRB can effectively improve the MPTP-induced Parkinson's disease mouse behavior index, increase the content of DA and its metabolites DOPAC and HVA in the brain, inhibit the loss of dopamine neurons in the substantia nigra and striatum, inhibit the expression of inflammatory factors and the activation of astrocytes and microglia in the substantia nigra; meanwhile, L-NRB can also inhibit the activity of MAO-B in the striatum. L-NRB has no toxic side effects in vivo and in vitro; has the advantages of high safety, small dosage, long-term stability and the like, and is suitable for further development for actual clinical treatment.

The invention belongs to the technical field of medicines, and particularly relates to application of a Chinese knotweed rhizome and aloe bowel-relaxing capsule to preparation of a medicine for treating Parkinson's disease. The Chinese knotweed rhizome and aloe bowel-relaxing capsule can obviously improve the damage of nigra and striatum dopaminergic neurons of mice suffering from the Parkinson's disease complicated with depression caused by MPTP and CUMS, and inhibit the activation of microglia and astroglia cells; the traditional Chinese medicine composition not only can relieve motion symptoms of mice with Parkinson's disease, but also can remarkably improve non-motion symptoms including mental disorder of the mice with Parkinson's disease, and has a remarkable treatment effect on depression of Parkinson's disease.

The application relates to a magnetic resonance imaging image processing method, device, storage medium and electronic equipment, which comprises the following steps: performing spatial alignment and size normalization processing on an original three-dimensional MRI image to obtain a normalized MRI image; performing segmentation on the normalized MRI image to obtain a mask image set containing multiple regions of interest, wherein the regions of interest include a substantia nigra, a striatum and a globus pallidus; performing double-flow factorization coding on brain tissue data corresponding to the mask image set to obtain content features related to pathology and style features related to an imaging domain; performing reconstruction based on the content features and the style features to obtain a reconstructed image; performing double-flow factorization coding based on the reconstructed image, performing physical disturbance and adversarial alignment on the obtained double-flow coding, and obtaining disturbance features; and obtaining the classification corresponding to the original three-dimensional MRI image based on the disturbance features and a classification model obtained through pre-training. The classification accuracy can be improved.

The invention relates to a fluorescent probe for targeting lipid droplets with long-term retention capacity, a preparation method and application thereof, and belongs to the technical field of fluorescent probes. The structural formula of the fluorescent probe is shown in the specification. The ClogP value of the fluorescent probe is greater than 8, high-specificity targeting to lipid droplets can be realized, and the fluorescent probe can be stably retained in living cells for 72 hours. The fluorescent probe not only can trace abnormal accumulation of lipid droplets in a Parkinson's disease model on a cellular level, but also can realize visual detection of lipid droplet pathological accumulation in a nigra area of a living animal model through intracerebral in-situ injection. The fluorescent probe is obtained by carrying out a Knoevenagel reaction on 4, 4 '-diformyl triphenylamine and benzothiazole-2-acetonitrile, and has the characteristics of simplicity and convenience in synthesis, good biocompatibility, high signal-to-noise ratio and long cell retention time.

This invention relates to the field of pharmaceutical technology for treating motor dysfunction in Parkinson's disease, and particularly to a traditional Chinese medicine preparation for treating motor dysfunction in Parkinson's disease. The formula consists of Cimicifuga rhizome, processed turtle shell, Angelica sinensis, raw licorice root, ginger-processed Pinellia ternata, Gastrodia elata, and scorpion. This invention uses a traditional Chinese medicine formula to treat motor dysfunction in Parkinson's disease. The medicinal materials comply with national regulations for the management of traditional Chinese medicine materials and have undergone clinical testing. The formula is rationally formulated with high synergistic effects and long-lasting and stable efficacy. Based on the principles of traditional Chinese medicine syndrome differentiation and treatment, this formula addresses the deficiency of both liver and kidney, and the insufficiency of qi and blood, with tremor and paralysis attributed to internal liver wind. It significantly improves motor dysfunction and tremor symptoms in Parkinson's disease. This preparation is highly effective, safe, reliable, and has few side effects. It can also significantly reduce the expression levels of tyrosine hydroxylase in the substantia nigra and striatum. This preparation represents a new approach to treating motor dysfunction in Parkinson's disease and has broad prospects in the field of treating this condition.

The invention relates to the technical field of disease model construction, in particular to a construction method of a vascular Parkinson's syndrome composite animal model. The method comprises the following steps: sequentially performing chronic whole-brain hypoperfusion treatment and systemic mitochondrial complex I inhibition treatment on an advanced mammal, and applying the vascular Parkinson's syndrome animal model to preparation of a medicine for screening or evaluating prevention and / or treatment of the vascular Parkinson's syndrome. According to the construction method of the vascular Parkinson's syndrome composite animal model provided by the invention, a stable cerebrovascular lesion and a definite nigra-strike dopamine energy system are simultaneously induced on the same animal individual through an innovative double-strike modeling method; therefore, a brand-new animal model which is highly similar to human diseases in pathology is created.

The application discloses application of Dendrofin D in preparation of a medicine for preventing and / or treating Parkinson's disease, wherein the Parkinson's disease is caused by deficiency of a trace element, and the trace element is selenium; Dendrofin D can reduce MPP+-induced cell damage and damage of TH+ neurons in the substantia nigra, and can reduce motor disorders and non-motor disorders caused by Parkinson's disease; meanwhile, Dendrofin D and catalpol are combined to be applied in preparation of the medicine for preventing and / or treating Parkinson's disease, and the combination can effectively improve the protection on Parkinson's disease and related symptoms caused by the Parkinson's disease, has the effects of preventing and treating Parkinson's disease, and can improve motor disorders and non-motor disorders related to Parkinson's disease.

The invention relates to an application of a traditional Chinese medicine composition in preparation of a medicine for Parkinson's disease, which is characterized in that the traditional Chinese medicine composition is prepared from ginseng, rehmannia, cistanche, salvia miltiorrhiza, polygala tenuifolia, rhizoma acori graminei and curcuma aromatica. The composition provided by the invention can obviously improve mouse dyskinesia caused by a Parkinson's disease model, reduce level rise of IL-1beta, IL-18 and TNF-alpha caused by the mouse Parkinson's disease model, obviously increase the level of DA in nigra of brain tissues of rats with Parkinson's disease, and reduce the levels of IL-1beta and IL-6, and has a good treatment effect on Parkinson's disease.

This invention belongs to the field of pharmaceutical technology, specifically relating to the application of Shouhui Tongbian Capsules in the preparation of drugs for treating Parkinson's disease. Shouhui Tongbian Capsules can significantly improve the damage to dopamine neurons in the substantia nigra and striatum of Parkinson's disease mice with depression induced by MPTP and CUMS, and inhibit the activation of microglia and astrocytes; it not only alleviates the motor symptoms of Parkinson's disease mice, but also significantly improves the non-motor symptoms of Parkinson's disease mice, including mental disorders, and has a significant therapeutic effect on depression caused by Parkinson's disease.

The application discloses a MAPKAPK2 molecule and application thereof to auxiliary diagnosis of Parkinson's disease. + The expression level of the MAPKAPK2 gene in peripheral blood, substantia nigra and prefrontal lobe of PD patients and healthy people is significantly different, and the MAPKAPK2 gene can be used as a potential molecular marker or target point of Parkinson's disease, applied to early clinical diagnosis and targeted treatment of Parkinson's disease, and is favorable for further elucidation of the occurrence and development mechanism and signal pathways of Parkinson's disease, and has great application prospect and theoretical value.