20 results about "Cimicifuga" patented technology

The invention discloses a traditional Chinese medicine preparation for treating multi-system atrophic upright hypotension and a preparation method. The traditional Chinese medicine preparation is prepared from the following raw materials: ginseng, astragalus membranaceus, antler, roasted ephedra, rehmannia, radix ophiopogonis, radix paeoniae alba, rhizoma cimicifugae and pericarpium citri reticulatae viride. The traditional Chinese medicine composition has the effects of tonifying qi, warming yang, nourishing blood and yin and ascending and descending qi function, and emphasizes the effect of ascending and descending qi function in blood pressure regulation by perfecting the etiology and pathogenesis of MSA erect hypotension; the pathogenesis of the MSA erect hypotension is mainly viscera asthenia and qi and blood ascending and descending disorder, so that the treatment effect is achieved by ascending yang and nourishing yin.

The invention discloses a kind of plant sunscreen synergistic composition and application thereof, belong to the field of cosmetics technology; The plant sunscreen synergistic composition provided by the present invention includes the following components in parts by mass: 0.1-1 parts of Cimicifuga extract, 0.3-1 parts of Eucommia leaf extract, 1-3 parts of Rambutan peel extract, 5-10 parts of Cyperus root extract. The present invention is compounded by selecting the components of appropriate mass ratio, and the obtained composition has a good effect of absorbing ultraviolet rays, and also has excellent anti-inflammatory and soothing effect. Moreover, when subsequently added into sunscreen products, it can effectively stabilize the physical sunscreen and chemical sunscreen in sunscreen lotion, and can also enhance the sunscreen effect of physical sunscreen and chemical sunscreen, improve the durability of sunscreen products, and can enhance the repair of sunscreen products to skin after sun exposure.

The invention provides a traditional Chinese medicine composition for treating acute altitude sickness. The traditional Chinese medicine composition is prepared from ginseng, astragalus membranaceus, acanthopanax, rhodiola rosea, turnip, salvia miltiorrhiza, dogwood, poria cocos, rhizoma cimicifugae, radix bupleuri, platycodon grandiflorum, aster, elecampane, rhizoma anemarrhenae and liquorice. The traditional Chinese medicine composition disclosed by the invention can be used for treating the acute altitude sickness, remarkably prolonging the load-bearing swimming time of rats, remarkably increasing the arterial oxygen partial pressure and the arterial oxygen saturation of acute altitude sickness model rats and relieving physical fatigue, has obvious effects of resisting anoxia, improving acid-base balance and resisting inflammation, and has obvious curative effects on myocardial injury, liver injury, liver injury and the like. And the kidney injury can be protected.

The invention discloses a fingerprint spectrum construction method of a traditional Chinese medicine composition containing salvia miltiorrhiza and astragalus membranaceus. The construction method comprises the following steps: taking a test solution and a reference solution of the traditional Chinese medicine composition for detection; obtaining content information of a reference substance of the traditional Chinese medicine composition according to a detection result; wherein the traditional Chinese medicine composition comprises salvia miltiorrhiza, radix polygonati officinalis, caulis clematidis armandii, ligusticum, liquorice, bighead atractylodes rhizome, rhizoma smilacis glabrae, radix saposhnikoviae, radix rehmanniae recen, radix ophiopogonis and astragalus membranaceus, and the reference substances are caffeic acid, liquiritin, rehmannia glutinosa libosch D, cimicifugin, astilbin, salvianolic acid B and ammonium glycyrrhizinate. The detection method is simple, accurate, efficient, good in stability, high in precision, good in reproducibility, convenient and easy to master, energy can be effectively saved, the analysis cost is reduced, and the technical content is not disclosed in the prior art.

The invention belongs to the technical field of traditional Chinese medicine pharmacy, and particularly relates to a rhizoma cimicifugae extract grading treatment device. The invention discloses a rhizoma cimicifugae extract grading treatment device, and aims to solve the problems that in the prior art, a rhizoma cimicifugae extract is easy to agglomerate, thermosensitive components are easy to degrade, the grading precision is greatly influenced by flow field fluctuation, and the continuous production stability is poor. The device comprises a multi-dimensional pre-dispersion unit, a low-temperature controlled grading cavity, a dynamic balance centripetal moment adjusting mechanism, a self-adaptive anti-adhesion lining system and a closed-loop circulation flow control system. Through the synergistic effects of high-frequency sound field pre-dispersion, low-temperature jacket temperature control, centrifugation-air resistance dynamic balance separation, micro-vibration adhesion prevention and the like, efficient protection and accurate classification of triterpenoid saponin and phenolic acid components are achieved. The grading precision, the drug effect retention rate and the continuous operation stability can be remarkably improved, and the method is suitable for precise grading of the heat-sensitive traditional Chinese medicine extract.

This invention discloses a traditional Chinese medicine composition for assisting in the improvement of hand-foot-mouth disease in infants and young children, belonging to the field of traditional Chinese medicine technology. The composition consists of eight medicinal herbs: lotus leaf, coix seed, angelica dahurica, kudzu root, platycodon root, agastache rugosa, cimicifuga rhizome, and dandelion, with a defined optimal medicinal ratio. Based on the seasonal differences in the pathogenesis of hand-foot-mouth disease, this invention targets the core pathologies of winter (cold congestion of microvessels, water and sodium retention, and internal heat generation) and spring and summer (hypothalamic sympathetic activation, increased heart rate, and visceral heat overload). It also addresses the technical deficiencies of clinical Western medicine, cold-natured traditional Chinese medicine, calamine lotion, and diuretics, such as vasoconstriction, kidney damage, central nervous system disorders, increased skin exudation, and rebound water retention. This invention employs a combination of warming and cooling herbs, regulating the ascending and descending functions, and promoting diuresis and protecting the body's vital energy. The synergistic effects of these herbs can dilate spasmodic microvessels, improve renal perfusion, stabilize abnormal heart rates, stabilize the hypothalamic center, and assist in antagonizing enteroviruses. By targeting and reducing abnormal permeability of skin capillaries with Angelica dahurica and Platycodon grandiflorus, it reduces blood extravasation and inhibits the formation and exudation of herpes from the root cause. This invention has mild medicinal properties, is suitable for all seasons, and has high safety. It can effectively improve symptoms of hand-foot-mouth disease such as fever, herpes, irritability, and cold extremities, reduce the risk of severe illness, antagonize the toxic side effects of commonly used clinical drugs, and is suitable for the delicate constitution of infants and young children, possessing good prospects for clinical application and promotion.

A wild-imitating cultivation method for under-forest cimicifuga foetida comprises the following steps: 1) forest land selection: selecting a forest land with the coverage of 40-80%; 2) soil preparation and fertilization; 3) transplanting plantlets: transplanting cimicifuga foetida with the seedling age of 3-5 years, dipping roots with a bactericide before transplanting, covering with soil after transplanting, treading tightly, and watering sufficiently; 4) field management; 5) harvesting and seedling stage management: starting to harvest fresh and tender stems of the cimicifuga foetida in the second year after transplanting, covering the seedlings with organic detritus sandy soil after the cimicifuga foetida is unearthed, performing shading treatment to prevent lignification of the fresh and tender stems, and when leaves of part of branches of the cimicifuga foetida grow out of the covered organic detritus sandy soil heap and the leaves are about to unfold, covering the seedlings with the organic detritus sandy soil heap with the covering height of 20-25cm to prevent lignification of the fresh and tender stems. Removing the organic detritus sand soil heap, cutting off the fresh and tender stems close to the earth surface, then recovering the organic detritus sand soil heap, keeping 3-5 branches for each cluster of cimicifuga foetida, and ensuring the later growth of the cimicifuga foetida; according to the method, the growth condition of the cimicifuga foetida is good, the harvesting period is long, and the yield is high.

This invention belongs to the field of biomedical technology, specifically disclosing the application of cimicifuga in the preparation of drugs for treating periodontitis. Specifically, it relates to the application of cimicifuga in the preparation of drugs for treating periodontitis; and the application of cimicifuga in the preparation of drugs for treating alveolar bone defects (periodontal bone defects) caused by periodontitis. It also relates to the application of cimicifuga in the preparation of products for inhibiting macrophage polarization towards M1 and / or promoting macrophage polarization towards M2 in a single macrophage system. In this disclosure, cimicifuga has no significant toxicity to macrophages and has high safety; it targets and regulates macrophage polarization, inhibiting periodontal inflammation at its source; it significantly reduces inflammatory infiltration and osteoclast formation in periodontal tissues, effectively alleviating alveolar bone defects; and it provides a novel targeted immunotherapy drug for periodontitis, expanding the clinical application of single traditional Chinese medicine monomers.

This invention discloses a fermented traditional Chinese medicine product, its preparation method, and its application, belonging to the field of traditional Chinese medicine fermentation technology. The product uses peppermint, astragalus, wolfberry, mulberry bark, anemarrhena, arborvitae leaf, scrophularia, cimicifuga, elsholtzia, angelica, lily, ginkgo, licorice, schisandra, eleutherococcus senticosus, ophiopogon japonicus, and dried ginger as raw materials, sorghum as a co-fermentation raw material, and brewing liquid as a fermentation enhancer. The process involves pretreatment of the traditional Chinese medicine, co-cooking with sorghum, saccharification with small-grain starter, segmented fermentation, extraction and purification, and post-treatment. This invention utilizes a "compound traditional Chinese medicine ~ sorghum" co-fermentation system, combined with the microbial community and active substances rich in brewing liquid, to increase the dissolution rate of active ingredients such as astragaloside A, lily polysaccharide, and wolfberry polysaccharide in the traditional Chinese medicine by more than 50%, while simultaneously converting them into easily absorbed small molecule derivatives. The finished product has an alcohol content controlled at 6-8 degrees, which not only promotes the absorption of active ingredients but also possesses synergistic effects of clearing the lungs and regulating qi, tonifying qi and benefiting the lungs, moistening the lungs and relieving cough, and clearing heat and resolving phlegm. The process enables the resource utilization of yellow water from brewing, reducing costs by 35%, and the product exhibits excellent stability, making it suitable for industrial production. It also has significant value in the field of lung function regulation and health care.

The invention is applicable to the field of medicines, and particularly relates to a rhizoma cimicifugae-containing traditional Chinese medicine composition for treating Alzheimer's disease, which comprises the following components in parts by weight: 5-15 parts of rhizoma cimicifugae, 8-12 parts of ginseng, 10-15 parts of astragalus membranaceus, 6-10 parts of salvia miltiorrhiza, 4-8 parts of rhizoma acori graminei, 3-6 parts of polygala tenuifolia, 5-8 parts of spina date seed, 10-15 parts of poria cocos, 6-10 parts of radix ophiopogonis, 12-18 parts of oyster, 8-12 parts of concha haliotidis and 4-8 parts of gastrodia elata. The cimicifugae foetidae-containing traditional Chinese medicine composition for treating the Alzheimer's disease has the beneficial effects that the cognitive function is improved: the salvia miltiorrhiza, the rhizoma acori graminei and the polygala tenuifolia can promote cerebral blood perfusion, enhance synaptic plasticity and inhibit neuronal apoptosis; the rhizoma cimicifugae and the radix astragali are combined to improve brain microcirculation and reduce beta-amyloid protein aggregation, so that the learning and memory ability is remarkably improved.

The present invention belongs to the technical field of fish medicines and discloses a traditional Chinese medicine composition for alleviating fatty liver disease in largemouth bass. The composition comprises the following components by weight: 20 parts of bupleurum root, 20 parts of kudzu root, 10 parts each of scutellaria baicalensis, white peony root, pinellia tuber, ginger, and immature bitter orange, 6 parts of rhubarb, 20 parts of smilax glabra, 20 parts of dandelion, 10 parts of platycodon grandiflorum, 10 parts of cimicifuga, and jujube; wherein 4 jujubes are added to every 20g of bupleurum root. The drug of the present invention has the advantages of good therapeutic effect, low cost, convenient consumption, and no side effects for treating fatty liver disease.

This invention discloses a crystalline form of cimicifuga glycoside, its preparation method, and its uses. This crystalline form has good stability, higher solubility and bioavailability, and advantages in gut microbiota.

The invention relates to a traditional Chinese medicine composition for preventing constipation after stroke, an application and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12 to 15 parts of fructus aurantii, 9 to 12 parts of radix aucklandiae, 10 to 15 parts of fructus akebiae, 6 to 8 parts of cassia twig, 10 to 12 parts of vinegar rhizoma cyperi, 6 to 8 parts of rhizoma zingiberis, 10 to 15 parts of poria cocos and 3 to 5 parts of rhizoma cimicifugae. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility, has the effects of relaxing bowel, warming yang, relaxing bowels, invigorating spleen, replenishing qi, ascending lucidity, descending turbid and the like, promotes the recovery of normal conduction functions of intestinal tracts, and effectively prevents the occurrence of early constipation of apoplexy patients.

The invention discloses an application of a cimicifuga foetida active component in regulation and control of glycolysis key genes to inhibit hepatocellular carcinoma, and belongs to the technical field of biomedicine.Experiments prove that the cimicifuga foetida active component can regulate and control expression of the glycolysis key genes and inhibit the progress of liver cancer; the active ingredients of the rhizoma cimicifugae can remarkably reduce mRNA expression of glycolysis key genes (ENO1 group, G6PD group and ALDOA group), so that proliferation of liver cancer cells is inhibited. The anti-hepatoma action way of the traditional Chinese medicine monomer is perfectly clarified to a certain extent, the research of traditional Chinese medicine in hepatoma is promoted, and the application prospect of the traditional Chinese medicine in treating hepatoma is increased.

This invention relates to the field of pharmaceutical technology for treating motor dysfunction in Parkinson's disease, and particularly to a traditional Chinese medicine preparation for treating motor dysfunction in Parkinson's disease. The formula consists of Cimicifuga rhizome, processed turtle shell, Angelica sinensis, raw licorice root, ginger-processed Pinellia ternata, Gastrodia elata, and scorpion. This invention uses a traditional Chinese medicine formula to treat motor dysfunction in Parkinson's disease. The medicinal materials comply with national regulations for the management of traditional Chinese medicine materials and have undergone clinical testing. The formula is rationally formulated with high synergistic effects and long-lasting and stable efficacy. Based on the principles of traditional Chinese medicine syndrome differentiation and treatment, this formula addresses the deficiency of both liver and kidney, and the insufficiency of qi and blood, with tremor and paralysis attributed to internal liver wind. It significantly improves motor dysfunction and tremor symptoms in Parkinson's disease. This preparation is highly effective, safe, reliable, and has few side effects. It can also significantly reduce the expression levels of tyrosine hydroxylase in the substantia nigra and striatum. This preparation represents a new approach to treating motor dysfunction in Parkinson's disease and has broad prospects in the field of treating this condition.

The present invention relates to the field of biomedicine, and more particularly to the use of a Cimicifuga extract, Ganoderma lucidum polysaccharide, and NADPH in combination for the preparation of a medicament for treating severe sepsis. The present invention provides the use of a Cimicifuga extract, Ganoderma lucidum polysaccharide, and NADPH in combination for the preparation of a medicament for treating severe sepsis. The combined use of these three active substances not only has excellent anti-inflammatory effects but also protects body organs, effectively blocks the progression of sepsis, and treats severe sepsis.

The invention discloses a planting method and application of a divaricate saposhnikovia root medicinal material. Belongs to the technical field of traditional Chinese medicines. The planting method comprises the following steps that 1, three-year-old cultivated windproof plants are collected and washed with tap water to remove silt of the windproof plants, and adaptive water planting is conducted on the windproof plants 7 days before windproof plant samples are collected; step 2, transferring the divaricate saposhnikovia plants subjected to adaptive hydroponic culture into a constant-temperature and constant-humidity greenhouse, culturing for 2 days by using a hydroponic solution and 15% PEG-6000, culturing for 2 days by using a hydroponic solution and 30% PEG-6000, and culturing for 4 days by using a hydroponic solution and 10% PEG-6000; and step 3, after the culture is completed, transplanting to a planting field. The contents of chromone components cimicifugin, 5-O-methylvisammioside and secondary metabolite cimicifugin in the divaricate saposhnikovia root medicinal material obtained by the invention are obviously increased, and are superior to those in wild divaricate saposhnikovia root.

The rhizoma cimicifugae extract preparation device comprises a vibrating screen plate and a bearing frame, a smashing box is welded in the bearing frame, a PLC is installed at one end of the smashing box, and the top end and the bottom end in the smashing box are connected with a first smashing roller and a second smashing roller respectively; and a first servo motor and a second servo motor which are connected with the first crushing roller and the second crushing roller are sequentially mounted on the outer side wall of the crushing box. By installing the second screw feeder and the like, the structure of the device is optimized, a user can start third servo motors on the top of the first screw feeder and the top of the second screw feeder to drive corresponding screw feeding rods to move, synchronous, automatic and uniform feeding operation of different rhizoma cimicifugae processing raw materials is achieved, and the machining efficiency of the rhizoma cimicifugae is improved. The problems of inconvenience in operation, time waste and labor waste caused by manual feeding are solved, and the automation degree and the machining efficiency of the device are improved.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a traditional Chinese medicine compound preparation for reducing blood sugar and blood fat and a preparation method thereof.The monarch drug raw radix astragali has the effects of invigorating the spleen, tonifying qi and strengthening the root, the monarch drug cimicifugae foetidae-radix bupleuri is matched to construct a qi activity lifting hub, and the limitation that a traditional blood sugar reducing prescription purely nourishes yin and clears heat is broken through; a composite scheme of fire depression and simultaneous elimination of phlegm and blood stasis is adopted, iridoid components in cimicifugae foetidae promote M2 polarization of macrophages and reduce IL-1beta expression, a'body fluid production promoting and thirst quenching 'component taking puerarin as a carrier is combined with raw and cooked rehmannia root verbascoside to form an intestinal GLP-1 secretion enhancement effect, and meanwhile, the composition also has the characteristic of enhancing bioavailability; by optimizing the monarch, minister, assistant and guide relationship of the raw radix astragali, rhizoma atractylodis, rhizoma atractylodis macrocephalae and other medicinal materials, an intervention path of tonifying qi and yin and detoxifying and activating blood is established.

The invention discloses a traditional Chinese medicine formula for treating ARDS caused by sepsis. Comprising rhizoma phragmitis, peach kernels, wax gourd kernels, coix seeds, cortex mori radicis, cortex lycii radicis, vinegar-processed radix curcumae, blackberry lily, honey-fried ephedra, tetrapanax papyriferus, inula flowers, madder, cimicifugae foetidae, turtle shells, angelica sinensis, platycodon grandiflorum, liquorice, radix ophiopogonis, schisandra chinensis, almonds, radix scrophulariae, radix trichosanthis, rheum officinale, radix asteris, cortex moutan, fructus trichosanthis, rhizoma pinellinae praeparata, ginger-processed bamboo shavings, fructus aurantii, mangnolia officinalis, raw malt, semen sojae germinatum and fresh bamboo juice. The embodiment of the invention further discloses a preparation method of the traditional Chinese medicine for treating the ARDS caused by sepsis. Compared with the prior art, the traditional Chinese medicine composition has the effects of opening and freeing lung arthralgia, clearing away fire and extinguishing wind, dredging collaterals and dispersing blood stasis, and relaxing bowel and purging turbidity, and can be used for treating ARDS (arterial thrombosis syndrome) caused by sepsis as well as endogenous phlegm, fluid retention, turbidity, blood stasis, wind, fire and toxin.