9 results about "Cimicifuga" patented technology

The invention provides a traditional Chinese medicine composition for treating acute altitude sickness. The traditional Chinese medicine composition is prepared from ginseng, astragalus membranaceus, acanthopanax, rhodiola rosea, turnip, salvia miltiorrhiza, dogwood, poria cocos, rhizoma cimicifugae, radix bupleuri, platycodon grandiflorum, aster, elecampane, rhizoma anemarrhenae and liquorice. The traditional Chinese medicine composition disclosed by the invention can be used for treating the acute altitude sickness, remarkably prolonging the load-bearing swimming time of rats, remarkably increasing the arterial oxygen partial pressure and the arterial oxygen saturation of acute altitude sickness model rats and relieving physical fatigue, has obvious effects of resisting anoxia, improving acid-base balance and resisting inflammation, and has obvious curative effects on myocardial injury, liver injury, liver injury and the like. And the kidney injury can be protected.

The invention belongs to the technical field of traditional Chinese medicine pharmacy, and particularly relates to a rhizoma cimicifugae extract grading treatment device. The invention discloses a rhizoma cimicifugae extract grading treatment device, and aims to solve the problems that in the prior art, a rhizoma cimicifugae extract is easy to agglomerate, thermosensitive components are easy to degrade, the grading precision is greatly influenced by flow field fluctuation, and the continuous production stability is poor. The device comprises a multi-dimensional pre-dispersion unit, a low-temperature controlled grading cavity, a dynamic balance centripetal moment adjusting mechanism, a self-adaptive anti-adhesion lining system and a closed-loop circulation flow control system. Through the synergistic effects of high-frequency sound field pre-dispersion, low-temperature jacket temperature control, centrifugation-air resistance dynamic balance separation, micro-vibration adhesion prevention and the like, efficient protection and accurate classification of triterpenoid saponin and phenolic acid components are achieved. The grading precision, the drug effect retention rate and the continuous operation stability can be remarkably improved, and the method is suitable for precise grading of the heat-sensitive traditional Chinese medicine extract.

This invention discloses a traditional Chinese medicine composition for assisting in the improvement of hand-foot-mouth disease in infants and young children, belonging to the field of traditional Chinese medicine technology. The composition consists of eight medicinal herbs: lotus leaf, coix seed, angelica dahurica, kudzu root, platycodon root, agastache rugosa, cimicifuga rhizome, and dandelion, with a defined optimal medicinal ratio. Based on the seasonal differences in the pathogenesis of hand-foot-mouth disease, this invention targets the core pathologies of winter (cold congestion of microvessels, water and sodium retention, and internal heat generation) and spring and summer (hypothalamic sympathetic activation, increased heart rate, and visceral heat overload). It also addresses the technical deficiencies of clinical Western medicine, cold-natured traditional Chinese medicine, calamine lotion, and diuretics, such as vasoconstriction, kidney damage, central nervous system disorders, increased skin exudation, and rebound water retention. This invention employs a combination of warming and cooling herbs, regulating the ascending and descending functions, and promoting diuresis and protecting the body's vital energy. The synergistic effects of these herbs can dilate spasmodic microvessels, improve renal perfusion, stabilize abnormal heart rates, stabilize the hypothalamic center, and assist in antagonizing enteroviruses. By targeting and reducing abnormal permeability of skin capillaries with Angelica dahurica and Platycodon grandiflorus, it reduces blood extravasation and inhibits the formation and exudation of herpes from the root cause. This invention has mild medicinal properties, is suitable for all seasons, and has high safety. It can effectively improve symptoms of hand-foot-mouth disease such as fever, herpes, irritability, and cold extremities, reduce the risk of severe illness, antagonize the toxic side effects of commonly used clinical drugs, and is suitable for the delicate constitution of infants and young children, possessing good prospects for clinical application and promotion.

A wild-imitating cultivation method for under-forest cimicifuga foetida comprises the following steps: 1) forest land selection: selecting a forest land with the coverage of 40-80%; 2) soil preparation and fertilization; 3) transplanting plantlets: transplanting cimicifuga foetida with the seedling age of 3-5 years, dipping roots with a bactericide before transplanting, covering with soil after transplanting, treading tightly, and watering sufficiently; 4) field management; 5) harvesting and seedling stage management: starting to harvest fresh and tender stems of the cimicifuga foetida in the second year after transplanting, covering the seedlings with organic detritus sandy soil after the cimicifuga foetida is unearthed, performing shading treatment to prevent lignification of the fresh and tender stems, and when leaves of part of branches of the cimicifuga foetida grow out of the covered organic detritus sandy soil heap and the leaves are about to unfold, covering the seedlings with the organic detritus sandy soil heap with the covering height of 20-25cm to prevent lignification of the fresh and tender stems. Removing the organic detritus sand soil heap, cutting off the fresh and tender stems close to the earth surface, then recovering the organic detritus sand soil heap, keeping 3-5 branches for each cluster of cimicifuga foetida, and ensuring the later growth of the cimicifuga foetida; according to the method, the growth condition of the cimicifuga foetida is good, the harvesting period is long, and the yield is high.

This invention belongs to the field of biomedical technology, specifically disclosing the application of cimicifuga in the preparation of drugs for treating periodontitis. Specifically, it relates to the application of cimicifuga in the preparation of drugs for treating periodontitis; and the application of cimicifuga in the preparation of drugs for treating alveolar bone defects (periodontal bone defects) caused by periodontitis. It also relates to the application of cimicifuga in the preparation of products for inhibiting macrophage polarization towards M1 and / or promoting macrophage polarization towards M2 in a single macrophage system. In this disclosure, cimicifuga has no significant toxicity to macrophages and has high safety; it targets and regulates macrophage polarization, inhibiting periodontal inflammation at its source; it significantly reduces inflammatory infiltration and osteoclast formation in periodontal tissues, effectively alleviating alveolar bone defects; and it provides a novel targeted immunotherapy drug for periodontitis, expanding the clinical application of single traditional Chinese medicine monomers.

This invention discloses a fermented traditional Chinese medicine product, its preparation method, and its application, belonging to the field of traditional Chinese medicine fermentation technology. The product uses peppermint, astragalus, wolfberry, mulberry bark, anemarrhena, arborvitae leaf, scrophularia, cimicifuga, elsholtzia, angelica, lily, ginkgo, licorice, schisandra, eleutherococcus senticosus, ophiopogon japonicus, and dried ginger as raw materials, sorghum as a co-fermentation raw material, and brewing liquid as a fermentation enhancer. The process involves pretreatment of the traditional Chinese medicine, co-cooking with sorghum, saccharification with small-grain starter, segmented fermentation, extraction and purification, and post-treatment. This invention utilizes a "compound traditional Chinese medicine ~ sorghum" co-fermentation system, combined with the microbial community and active substances rich in brewing liquid, to increase the dissolution rate of active ingredients such as astragaloside A, lily polysaccharide, and wolfberry polysaccharide in the traditional Chinese medicine by more than 50%, while simultaneously converting them into easily absorbed small molecule derivatives. The finished product has an alcohol content controlled at 6-8 degrees, which not only promotes the absorption of active ingredients but also possesses synergistic effects of clearing the lungs and regulating qi, tonifying qi and benefiting the lungs, moistening the lungs and relieving cough, and clearing heat and resolving phlegm. The process enables the resource utilization of yellow water from brewing, reducing costs by 35%, and the product exhibits excellent stability, making it suitable for industrial production. It also has significant value in the field of lung function regulation and health care.

This invention discloses a crystalline form of cimicifuga glycoside, its preparation method, and its uses. This crystalline form has good stability, higher solubility and bioavailability, and advantages in gut microbiota.

The invention discloses an application of a cimicifuga foetida active component in regulation and control of glycolysis key genes to inhibit hepatocellular carcinoma, and belongs to the technical field of biomedicine.Experiments prove that the cimicifuga foetida active component can regulate and control expression of the glycolysis key genes and inhibit the progress of liver cancer; the active ingredients of the rhizoma cimicifugae can remarkably reduce mRNA expression of glycolysis key genes (ENO1 group, G6PD group and ALDOA group), so that proliferation of liver cancer cells is inhibited. The anti-hepatoma action way of the traditional Chinese medicine monomer is perfectly clarified to a certain extent, the research of traditional Chinese medicine in hepatoma is promoted, and the application prospect of the traditional Chinese medicine in treating hepatoma is increased.

This invention relates to the field of pharmaceutical technology for treating motor dysfunction in Parkinson's disease, and particularly to a traditional Chinese medicine preparation for treating motor dysfunction in Parkinson's disease. The formula consists of Cimicifuga rhizome, processed turtle shell, Angelica sinensis, raw licorice root, ginger-processed Pinellia ternata, Gastrodia elata, and scorpion. This invention uses a traditional Chinese medicine formula to treat motor dysfunction in Parkinson's disease. The medicinal materials comply with national regulations for the management of traditional Chinese medicine materials and have undergone clinical testing. The formula is rationally formulated with high synergistic effects and long-lasting and stable efficacy. Based on the principles of traditional Chinese medicine syndrome differentiation and treatment, this formula addresses the deficiency of both liver and kidney, and the insufficiency of qi and blood, with tremor and paralysis attributed to internal liver wind. It significantly improves motor dysfunction and tremor symptoms in Parkinson's disease. This preparation is highly effective, safe, reliable, and has few side effects. It can also significantly reduce the expression levels of tyrosine hydroxylase in the substantia nigra and striatum. This preparation represents a new approach to treating motor dysfunction in Parkinson's disease and has broad prospects in the field of treating this condition.