271 results about "Molecularly imprinted polymer" patented technology

The invention constructs a universal visual virus molecularly imprinted sensor modified with an anti-protein coating, the sensor uses magnetic Fe3O4 as an imprinting carrier, HBV as a template and dopamine as a functional monomer for imprinting to obtain a molecularly imprinted polymer with a polydopamine coating (PDA), and before the template is removed, the molecular imprinting polymer with the polydopamine coating (PDA) is separated from the template, so that the molecular imprinting polymer with the polydopamine coating (PDA) is obtained. The surface of the PDA layer is covered with a slightly cross-linked PMEO2MA layer through a water precipitation polymerization method, and the polymer can effectively reduce non-specific protein adsorption; and finally, exposing an imprinting cavity of the PDA layer by eluting the template molecules. On the other hand, potassium permanganate (KMnO4) is used as a signal output molecule, and when no target object exists, the strong reducibility of PDA can enable KMnO4 entering the imprinting cavity to be subjected to a color fading reaction. Based on the principle, high-specificity colorimetric visual detection on the HBV is realized. The sensor can be combined with a smart phone through naked eyes to carry out visual semi-quantitative analysis and carry out quantitative detection through ultraviolet rays, and the universality of the sensor can be confirmed through a template replacement experiment. And meanwhile, the sensor shows an excellent cost advantage. The diagnosis which is high in sensitivity, low in cost and capable of achieving rapid visualization shows huge potential in practical application, and particularly has important application value in infectious disease screening and monitoring work in areas with limited resources.

The invention discloses a dual-emission molecular imprinting ratiometric fluorescence sensor, a preparation method thereof and application of the dual-emission molecular imprinting ratiometric fluorescence sensor in aureomycin detection, and belongs to the technical field of chemical sensors. The preparation method of the sensor comprises the following steps: preparing silicon dioxide-quantum dot composite nanoparticles, and preparing a molecularly imprinted polymer by taking salicylamide as a template molecule; and mixing the molecularly imprinted polymer and the silicon dioxide-quantum dot composite nanoparticles in an HEPES buffer solution by adopting a post-mixing strategy to construct the dual-emission molecularly imprinted ratiometric fluorescence sensor. The double-emission molecular imprinting ratiometric fluorescence sensor has the beneficial effects that the double-emission molecular imprinting ratiometric fluorescence sensor provided by the invention is rich in fluorescence color change, rapid, high-sensitivity and visual detection of aureomycin can be realized, the whole detection process is simple, convenient and rapid, and the double-emission molecular imprinting ratiometric fluorescence sensor is suitable for being widely popularized in practical application.

The invention relates to the field of material chemistry on-line detection, in particular to a 1, 2, 4-trichlorobenzene on-line detection material and a preparation method thereof, and provides a film-forming sensitive layer material capable of being coated on the surface of a transducer, and the film-forming sensitive layer material comprises chitosan, a crosslinking component with the content of 0.1-5wt% in terms of glutaraldehyde and magnetic core-shell molecularly imprinted particles after being dried, the magnetic core-shell molecularly imprinted particle contains a ferroferric oxide magnetic inner core, a silicon dioxide middle layer and a molecularly imprinted polymer shell layer, and the shell layer is a cyclodextrin methacrylate and ethylene glycol dimethacrylate copolymer network and takes 1, 2, 4-trichlorobenzene as a template. The material keeps the membrane integrity and long-term stability under the working conditions of circulation and regeneration and also gives consideration to quick response, and the residual 1, 2, 4-trichlorobenzene is controlled to be not greater than 0.10 wt% and the residual glutaraldehyde is controlled to be not greater than 0.5 wt%. The method is used for relieving structural mass transfer contradiction and processing and coating coupling contradiction caused by high filler load, and has online detection application value.

The invention discloses a cyclic regeneration treatment method of stainless steel pickling waste liquid, which realizes full-flow recycling of the pickling waste liquid by constructing a closed-loop system of pretreatment, adsorption, desorption, recovery, regeneration and circulation. A molecularly imprinted polymer adsorption technology is adopted, targeted capture of Cr < 3 + >, Ni < 2 + > and Fe < 2 + > / 3 < + > is achieved through specific recognition sites, and the bottleneck that a traditional adsorbent is poor in selectivity is broken through; the supercritical CO fluid extraction technology utilizes the characteristics of high diffusivity and low surface tension, efficient desorption of metal ions is achieved under mild conditions, and secondary pollution caused by a traditional organic solvent is avoided. A technical closed loop is formed among the steps through parameter synergy and substance circulation, and finally the dual purposes of full-amount regeneration of the pickling waste liquid and efficient recovery of metal resources are achieved.

The invention discloses a rhizoma polygonati polysaccharide rapid detection electrochemical sensor as well as a preparation method and application thereof, and relates to the field of electrochemical sensors. The method comprises the following steps: (1) preparing an AC-COOH-PANI composite material; (2) preparing an AC-COOH-PANI (at) GCE modified electrode; and (3) preparing the MIP-AC-COOH-PANI (at) GCE. According to the present invention, Glu is adopted as a template molecule, MAA is adopted as a functional monomer, a molecularly imprinted polymer film is constructed on the surface of an AC-COOH-PANI composite material modified GCE electrode through a self-assembly polymerization technology, and the molecularly imprinted electrochemical sensor MIP-AC-COOH-PANI (at) GCE for rapid detection of polygonatum sibiricum polysaccharide is developed, the sensor shows relatively low detection limit, relatively wide linear range, relatively high sensitivity and good selectivity and stability, and has a good application prospect.

To provide a body fluid-based biological detection device and method.SOLUTION: A device includes, from bottom to top, a water-filtering layer, a molecularly imprinted polymer layer, and a flexible substrate layer. A biochemical sensor is integrated on the flexible substrate layer. In one state, the water-filtering layer filters water from the body fluid. The molecularly imprinted polymer layer recognizes and binds to biomarkers within the filtered body fluid. The binding of the biomarkers to the molecularly imprinted polymer layer changes the current of the biochemical sensor, thereby converting the biological signal in the body fluid into a physical signal. The present invention provides a body fluid-based biological detection device and method with high sensitivity and stable detection results.SELECTED DRAWING: Figure 6

The invention relates to the technical field of health wine preparation, and discloses a multi-effect synergistic enhanced bear gall body-building wine compound preparation process which comprises the following steps: taking sorghum, corn and fructus lycii as fermentation base materials, and carrying out double-strain synergistic fermentation by adopting saccharomyces cerevisiae and lactobacillus plantarum; adding fresh ursodesoxycholic acid during fermentation, carrying out in-situ enzymatic debinding conversion by using a compound enzyme system generated by a fermentation system, and converting the bound bile acid into free ursodesoxycholic acid; after fermentation, distilling to obtain raw wine; a molecularly imprinted polymer prepared by taking a wolfberry polyphenol key monomer as a template molecule is adopted to carry out targeted anchoring refining on raw wine, selective capture and enrichment of wolfberry polyphenol are carried out, and finally aging is carried out to obtain a finished product. According to the method disclosed by the invention, upstream double-strain fermentation in-situ enzymatic conversion and downstream molecular imprinting targeted refining are systematically integrated, so that the technical contradictions that the conversion rate of combined bile acid is low and a large amount of polyphenol functional components are synchronously lost during purification and impurity removal in a traditional process are solved.

The present disclosure provides a molecularly imprinted polymer (MIP) selective for a perfluoroalkyl and polyfluoroalkyl substance (PFAS), an article comprising such an MIP, methods of making the same, and methods of using the same. The MIP comprises moieties of a monomer having a first portion for an electrically conductive polymer chain and a second portion comprising a N-oxyl side group for redox activity. The MIP is obtained through polymerization of the monomer in the presence of the specific PFAS as a template. The MIP is configured to be selective to the PFAS for a measurement of a concentration of the PFAS.

The invention discloses a multi-dimensional high-precision detection method and system for biotoxins in agricultural products, and the method comprises the steps: carrying out sterile collection and grading pretreatment on an agricultural product sample to obtain a homogenized sample; extracting the homogenized sample by adopting a mixed solvent system, adding an internal standard substance, carrying out salting-out layering, and collecting supernate; sequentially carrying out QuEChERS purification, multi-mechanism adsorption column purification and molecularly imprinted polymer specific enrichment on the supernate; carrying out dual-mode detection on the target toxin enrichment liquid, respectively carrying out quantitative detection by adopting a liquid chromatography-tandem mass spectrometry method, and carrying out screening detection by adopting an intelligent electrochemical sensing method; performing optimization processing on the dual-mode detection signal, and comprehensively judging a sample detection result; through integrated application of a triple purification mechanism, a dual-mode detection system, machine learning signal analysis and a full-chain quality control technology, efficient enrichment and deep interference removal of target toxins in a complex matrix can be realized, and both precision and applicability are considered.

The present application belongs to the technical field of adsorbing materials, and particularly relates to a titanium dioxide molecular imprinting polymer as well as a preparation method and application thereof. The present application uses Sudan red as a template molecule, acrylamide as a functional monomer, ethylene glycol dimethacrylate as a crosslinking agent, and azobisisobutyronitrile as an initiator to construct a cavity structure matching the Sudan red molecule on the surface of the amino-modified titanium dioxide ultrafine particles, and successfully prepares the titanium dioxide molecular imprinting polymer. The material combines the photocatalytic characteristics of the titanium dioxide and the selective recognition ability of the molecular imprinting, can degrade the Sudan red under light, and has a higher photocatalytic efficiency than that of the pure titanium dioxide. The material synthesized through the surface imprinting technology has a three-dimensional cavity complementary to the template molecule, and has a larger adsorption capacity than that of the non-imprinted material. The material realizes the integration of the selective recognition, adsorption and degradation of the Sudan red, and is suitable for complex industrial environments.

The present application relates to a kind of multifunctional saponins molecularly imprinted polymer template molecule, molecularly imprinted polymer and its application, belong to plant component refining technical field.The molecularly imprinted polymer of the present application uses virtual template molecule, the template molecule contains hydrogen bond donor and strong electronic effect, it has good adsorption performance to natural saponins compound molecules such as Jiumu saponin AIII, Jiumu saponin BII, Jiumu saponin BIII, Sanqi saponin R1, ginsenoside Rg1, ginsenoside Rg3, ginsenoside Rh2, Tribulus saponin K, Tribulus saponin D, Platanus orientalis saponin D, Shandeng saponin B, Chonglou saponin I, Chonglou saponin II, Chonglou saponin VI.The virtual template molecule is low in cost, can be used for the large-scale preparation of molecularly imprinted polymer, significantly reduces the extraction cost of natural saponins compound.

The invention discloses an interface molecularly imprinted polymer microsphere as well as a preparation method and application thereof, and relates to the technical field of functional polymer materials. The preparation method comprises the following steps: firstly, enabling template molecules to react with a silane coupling agent to form a template molecule compound; and then anchoring the template molecule compound on the surface of SiO2 particles, so that the template molecule compound simultaneously plays the dual roles of a stabilizer and an imprinting template in Pickering emulsion polymerization. And after the polymerization is completed, removing the template molecule modified SiO2 particles to obtain the polymer microspheres of which the imprinting sites are completely exposed on the surfaces of the microspheres. Molecular imprinting sites of the microspheres are uniformly distributed on the surface and are in an open and highly accessible state, so that the recognition rate and the binding capacity of target molecules are remarkably improved, and the microspheres have excellent selective enrichment and separation performance on target analytes; a reliable technical path is provided for practical application of the molecularly imprinted material in the fields of solid-phase extraction, sensing detection, medicine purification and the like.

The invention discloses a preparation method of curcumin, and belongs to the technical field of natural product extraction. The method comprises the following steps: firstly, adopting a modified deep-eutectic solvent into which propyl gallate is introduced as an extraction medium, and realizing high-selectivity extraction of curcumin through a special molecular structure of the modified deep-eutectic solvent; then the ultrasonic-microwave coupling technology is combined, so that the extraction efficiency is remarkably improved; finally, the modified molecularly imprinted polymer with magnetism is used for precise purification, the material has the specific recognition capacity and the rapid magnetic separation characteristic, polyethylene glycol is introduced to serve as a pore-foaming agent, and more active sites are provided for adsorption of curcumin molecules. According to the method disclosed by the invention, through collaborative innovation of all links, the whole process optimization from extraction to purification is realized, the product purity and the extraction efficiency are remarkably improved, the energy consumption and the solvent pollution are greatly reduced, and a reliable solution is provided for industrial production of the high-quality curcumin.

The invention discloses a preparation method of an MXene-based electro-polymerization molecularly imprinted polymer and application of the MXene-based electro-polymerization molecularly imprinted polymer in detection of sulfadimethoxine content. The preparation method comprises the steps of synthesis of an MXene-MOF composite material, preparation of the MXene-based electro-polymerization molecularly imprinted polymer and the like. The electrochemical detection of the SDM is realized by electrically polymerizing a layer of molecularly imprinted polymer on the surface of the MXene-based composite material. When SDM exists in a detection environment, an imprinting cavity with specific recognition capability is combined with the SDM through acting forces such as hydrogen bonds and the like, so that the electron transfer rate is hindered, and the current value is reduced. The quantitative detection of the SDM is realized by analyzing the relationship between the logarithm of the concentration of the SDM and the delta I current change value. The method has a wide concentration detection range and a low detection limit, and has a wide application prospect.

The invention relates to the technical field of traditional Chinese medicinal material detection, and particularly discloses an alpha-asarone extracting solution detection method and system based on a biosensor, and the method sequentially comprises the following steps: mixing medicinal material powder to be detected with an extraction solvent according to a certain solid-to-liquid ratio, and extracting volatile oil by adopting an ultrasonic or reflux method to obtain a crude extracting solution; volatile oil concentrated mother liquor is obtained; obtaining a standard solution; a combined-state electrode is obtained; obtaining electrochemical response data; and converting the electrochemical response data into the content of alpha-asarone in the sample according to the standard curve, and evaluating the precision, the recovery rate and the regeneration performance to obtain a final detection result. Recognition sites prepared by adopting the molecularly imprinted polymer are complementarily paired with template molecules in steric configuration, steric hindrance and key functional groups to realize specific recognition of alpha-asarone, so that false signals caused by matrix interference and non-specific adsorption are remarkably reduced; the electrochemical measurement method is extremely sensitive to electron transfer generated by surface bonding.

The invention provides a preparation method and application of a doxycycline (DOX) molecularly imprinted surface plasmon resonance (SPR) sensing chip. According to the chip, an SPR bare gold chip is used as a substrate, DOX is used as a template molecule, a molecularly imprinted polymer (MIP) recognition membrane is constructed on the surface of the chip, and collaborative integration of the MIP technology and the SPR technology is achieved. According to the strategy, the chip is endowed with specific recognition capability on template molecules DOX, and local refractive index change caused by combination of the DOX and the recognition film can be detected in real time in an unmarked manner, so that the detection sensitivity and accuracy are remarkably improved. By utilizing an SPR (Surface Plasmon Resonance) analyzer, the chip can realize rapid quantitative detection of DOX in a low concentration range, shows good reproducibility, and can be applied to detection of actual samples.

The invention belongs to the technical field of chrysin detection, and particularly relates to a dual-emission fluorescent molecularly imprinted polymer as well as a preparation method and application thereof. The method comprises the following steps: preparing carbon dots with different emission wavelengths; carrying out amination modification on the carbon dots; and preparing the dual-emission fluorescent molecularly imprinted polymer. The method also comprises the following steps: respectively adding the dual-emission fluorescent molecularly imprinted polymer into chrysin solutions with different known concentrations, carrying out fluorescence quenching reaction, and establishing a standard curve according to the linear relationship between the detected fluorescence intensity and the corresponding concentration of the chrysin solution; adding the dual-emission fluorescent molecularly imprinted polymer into a solution of a to-be-detected product, and carrying out fluorescence quenching reaction to obtain fluorescence intensity; and calculating the concentration of chrysin in the solution to be detected according to the standard curve. The preparation method is used for solving the technical problems that in the prior art, a single-emission fluorescent molecularly imprinted polymer has defects in the aspects of sensitivity, background fluorescence interference resistance in a complex environment and the like in the detection process.

The present invention discloses a molecularly imprinted electrochemical sensor and a preparation method and application thereof. A magnetic molecularly imprinted polymer is obtained by ATRP polymerization using a magnetic MOFs material as a carrier; the magnetic molecularly imprinted polymer is modified onto an electrode surface to obtain the molecularly imprinted electrochemical sensor. In the present invention, a silicon dioxide layer is coated on the surface of a magnetic core to effectively prevent the magnetic core from being oxidized or corroded. Hydroxyl groups are introduced by coating polydopamine on the surface of the magnetic core, which facilitates complexation with metal ions during the synthesis of the MOFs material. The introduction of the MOFs material enriches the recognition sites. An initiator for ATRP polymerization is introduced on the surface of magnetic nanoparticles coated with the MOFs material to prepare a molecularly imprinted polymer layer by surface-initiated atom transfer radical polymerization. The sensor has the characteristics of low separation and recovery difficulty, high recognition efficiency and short detection cycle, avoids the risk of template molecule leakage during use, and has high safety and reliability.

The invention belongs to the technical field of food safety detection, and particularly relates to a histamine molecular imprinting electrochemical sensor based on a carbon-based nano composite material and a preparation method and application of the histamine molecular imprinting electrochemical sensor. Aiming at the problems of poor selectivity, high detection limit or complicated operation and the like of the existing histamine detection technology, a Co3O4 / N-HCS (cobaltosic oxide / nitrogen-doped hollow carbon sphere) composite material is prepared by adopting a solvothermal method, o-phenylenediamine (o-PD) is taken as a functional monomer, a molecularly imprinted polymer membrane (MIP) is constructed on the surface of a glassy carbon electrode (GCE) by adopting an electropolymerization method, and the histamine detection electrode is prepared. The MIP / Co3O4 / N-HCS / GCE sensor with specific recognition sites on histamine is formed. The sensor has high selectivity, high sensitivity and good stability, is simple and convenient to operate and rapid in detection, can efficiently realize accurate detection of histamine in food, and is suitable for safety monitoring scenes of various foods such as fermented food, aquatic products and dairy products.

The invention discloses a phenylboronic acid affinity deoxynojirimycin imprinted polymer nano-material as well as a preparation method and application thereof, and belongs to the fields of nano-material preparation and natural compound extraction and separation. Phenylboronic acid modified nano silica gel is used as a carrier, deoxynojirimycin is used as a template molecule, dopamine is used as a cross-linking agent, a polyethyleneimine hyperbranched strategy is further combined, a deoxynojirimycin molecularly imprinted polymer (MIPs-PEI) with boric acid affinity and pH response characteristics is constructed, and hyperbranched modification remarkably improves hydrophilicity and boric acid affinity sites of the material. The synthesized MIPs-PEI has good adsorption performance on deoxynojirimycin and can effectively enrich deoxynojirimycin in mulberry leaves, and the natural hypoglycemic alkaloid deoxynojirimycin is extracted in a green mode through the method.

The invention discloses a chitosan modified ferroferric oxide / carboxylated multi-walled carbon nanotube-based molecularly imprinted electrochemical sensor as well as a preparation method and application thereof, and relates to the technical field of electrochemical sensing. The invention aims to solve the problems that the existing method for detecting carbendazim is complicated to operate and high in cost and the traditional sensor is poor in selectivity. The invention discloses a molecularly imprinted electrochemical sensor based on chitosan modified ferroferric oxide / carboxylated multi-walled carbon nanotubes. The molecularly imprinted electrochemical sensor comprises a glassy carbon electrode, and a molecularly imprinted polymer and CS-Fe3O4-CMWCNTs which are modified on the surface of the glassy carbon electrode, the molecularly imprinted polymer is prepared by taking carbendazim as a template molecule, methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linking agent and azodiisobutyronitrile as an initiator. The molecularly imprinted electrochemical sensor is applied to detection of carbendazim.

The invention discloses a molecularly imprinted membrane of a new psychoactive substance and a preparation method and application of the molecularly imprinted membrane, the molecularly imprinted membrane comprises a membrane substrate and an adsorption material layer arranged on the membrane substrate, and the material of the adsorption material layer comprises 3, 3 ', 4', 4 '-tetramethyl-3, 3', 4 '-tetramethyl-3, 3'-tetramethyl-3, 3 '-tetramethyl-3, 3'- The molecularly imprinted polymer is prepared by using 2, 4-methylenedioxyphenylethylamine as an alternative template and using a bulk polymerization method. The novel molecularly imprinted membrane prepared by combining a molecularly imprinted technology and a separation technology is used as a membrane extraction material, and integrates the advantages of a membrane extraction technology and an imprinting technology, so that the problems that a membrane material is easy to pollute and low in selectivity are solved, and the novel molecularly imprinted membrane is suitable for being used as a membrane extraction material. The method shows the capability of accurately identifying a target analyte in the membrane separation process, has the advantages of high efficiency, stability, repeatability and the like, and provides a new technical means and potential application for identifying and detecting common forbidden drugs in a water body.

This invention discloses a dual-emission molecularly imprinted ratiometric fluorescence sensor, its preparation method, and its application in the detection of chlortetracycline, belonging to the field of chemical sensor technology. The preparation method of this sensor includes the following steps: preparing silica-quantum dot composite nanoparticles; preparing a molecularly imprinted polymer using salicylamide as a template molecule; and using a post-mixing strategy to mix the molecularly imprinted polymer and silica-quantum dot composite nanoparticles in HEPES buffer to construct the dual-emission molecularly imprinted ratiometric fluorescence sensor. The advantages of this invention are: the dual-emission molecularly imprinted ratiometric fluorescence sensor provided by this invention exhibits rich fluorescence color changes, enabling rapid, highly sensitive, and visual detection of chlortetracycline; and the entire detection process is simple, convenient, and fast, making it suitable for widespread application in practical applications.

This invention discloses a molecularly imprinted modified electrode for detecting trifluoroacetic acid in water, its preparation method, and its application. An integrated composite sensing interface is constructed, comprising an enrichment layer, a recognition layer, and a conductive layer, wherein a monolayer Ti3C2T is used. x A three-dimensional conductive network is constructed as the conductive layer, significantly enhancing the electron transfer rate. A molecularly imprinted polymer is used as the conversion layer; its pre-designed specific recognition cavity accurately captures target molecules and converts the specific binding behavior of trifluoroacetic acid into a detectable electrochemical signal. UiO-66-F4 is used as the enrichment layer; leveraging the fluoride-loving interactions between fluorine atoms, trifluoroacetic acid molecules in the water sample are efficiently enriched at the electrode interface, significantly reducing the detection limit to as low as 6.94 ng / L. This molecularly imprinted modified electrode exhibits good selectivity and anti-interference capabilities, along with good repeatability, reducing the detection cost per sample and enabling sensitive and rapid detection of trifluoroacetic acid under complex water conditions.

The present invention relates to molecularly imprinted polymers (MIPs), especially those formed around template molecules with magnetic supports (magnetically supported template molecules). The invention allows magnetically supported template molecules to be recycled and reused in further rounds of MIP production thus significantly increasing MIP yields per unit mass of template molecule. Inventive methodologies for forming the magnetically supported template molecules, in particular their functionalised magnetic precursors, facilitates recycling under very mild conditions which leave the recycled protein template molecules intact, thereby maintaining the quality of MIPs formed therefrom.

The invention discloses a visual bifunctional subtype influenza virus molecularly imprinted sensor as well as a preparation method and application thereof. The sensor comprises a fluorescent signal core and a molecularly imprinted polymer layer coated outside the fluorescent signal core, the fluorescent signal core is SiO2 microspheres coated with CdTe quantum dots, the molecularly imprinted polymer layer is internally provided with an imprinting cavity capable of specifically recognizing the subtype influenza virus, the three-dimensional space shape of the imprinting cavity is complementary to that of the subtype influenza virus, and the molecularly imprinted polymer layer is coated with CdTe quantum dots. Sialic acid molecules are covalently modified on the inner surface. The sensor can be used for quantitative detection or visual semi-quantitative detection of subtype influenza viruses such as H7N9 and H5N1, and integrates double functions of rapid screening and accurate quantification. The sensor disclosed by the invention is good in preparation reproducibility, high in selectivity, strong in anti-interference capability and suitable for analysis of complex biological samples, and a novel user-friendly and efficient method is provided for on-site monitoring and early warning of influenza viruses.

The invention relates to the technical field of medical preparations or cosmetics, in particular to the technical field of preparation of plant-derived active ingredients in the medical preparations or cosmetics, and discloses a preparation process of a centella asiatica extract, which comprises the following steps: extracting centella asiatica to obtain a centella asiatica concentrated product from centella asiatica by adopting an enzyme-assisted hot ethanol extraction method in combination with a resin purification technology; the preparation method comprises the following steps: preparing centella asiatica extract molecularly imprinted polymer resin, filling a solid-phase extraction empty column with the centella asiatica extract molecularly imprinted polymer resin to prepare a resin column, and purifying a centella asiatica concentrated product through the resin column to prepare the centella asiatica extract with the purity as high as 99%. The centella asiatica extract prepared by the invention has repairing and soothing effects, can be used as an active ingredient in medical preparations or cosmetics, is used for preparing a gel preparation for treating skin injury, or is added into a repairing skin care product, and realizes the combination of a medical-grade skin care effect and daily care by promoting skin barrier repairing and soothing damaged parts.

This invention discloses a method for preparing and applying a wearable formaldehyde gas sensor based on molecularly imprinted polymers. The preparation method includes the following steps: forming a heart-shaped electrode stepwise on a flexible substrate using screen printing technology; synthesizing a thin layer of polypyrrole-based molecularly imprinted polymer on the working electrode of the heart-shaped electrode using electropolymerization technology; immersing the synthesized electrode in a mixed solution of acetic acid and methanol; and drying to obtain the wearable formaldehyde gas sensor. This method and application of the wearable formaldehyde gas sensor, through a combination of molecular imprinting technology, screen printing, and electropolymerization, prepares a layered structure of "carbon paste-molecularly imprinted polymer" on a flexible substrate. It can rapidly respond to formaldehyde gas at ppm levels at room temperature, maintains good working condition during multiple bending tests, and exhibits extremely strong selectivity for formaldehyde in complex working environments. The preparation process is simple, low-cost, and highly practical.

The invention discloses a method for reducing COD (Chemical Oxygen Demand) of tetrahydrofuran production process wastewater, which comprises the following steps: S1, introducing the tetrahydrofuran production process wastewater into a molecular imprinting adsorption unit to selectively adsorb 1, 4-butanediol in the wastewater; s2, performing in-situ regeneration treatment on the molecularly imprinted polymer; meanwhile, the effluent is conveyed to a Fenton oxidation unit for oxidation treatment; s3, the outlet water is conveyed to an iron removal unit for iron removal operation; s4, introducing the effluent into a photocatalytic membrane separation unit, and carrying out photocatalytic oxidation degradation operation; and S5, sending the effluent to an activated carbon adsorption unit for adsorption treatment, and discharging the effluent after the effluent reaches the discharge standard. According to the wastewater treatment method disclosed by the invention, the 1, 4-butanediol can be efficiently and selectively removed, and the load of a subsequent working section is greatly reduced; and by virtue of the advantages of high-selectivity adsorption, strong oxidation, membrane self-cleaning and the like, the COD (Chemical Oxygen Demand) of the effluent is stably lower than the discharge standard, the whole process is stable in operation, and the long-term wastewater treatment requirement can be met.