Preparation method for molecular imprinting material and molecular imprinting material prepared through preparation method

A molecularly imprinted and nanoparticle technology, applied in the preparation of molecularly imprinted materials, in the field of molecularly imprinted materials, can solve the problems of complex preparation process while identifying and separating secretion interferers, avoid swelling phenomenon, simple reaction conditions, and improve biological phase. capacitive effect

Inactive Publication Date: 2015-12-02
INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The first purpose of the present invention is to provide a method for preparing molecularly imprinted materials, which aims to solve the problem that the existing molecularly imprinted materials are complicated in preparation process and unable to simultaneously identify and separate and enrich a variety of environmental endocrine disruptors with large differences in structure The problem
This material solves the problem that existing molecularly imprinted materials cannot simultaneously identify and separate and enrich a variety of environmental endocrine disruptors with large structural differences. It has more recognition sites and better recognition performance, strong magnetism, and fast adsorption speed. , high efficiency, can realize simultaneous efficient selective identification and separation and enrichment of various steroids and phenolic EDCs in environmental and food samples

Method used

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  • Preparation method for molecular imprinting material and molecular imprinting material prepared through preparation method
  • Preparation method for molecular imprinting material and molecular imprinting material prepared through preparation method
  • Preparation method for molecular imprinting material and molecular imprinting material prepared through preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0062] Such as figure 1 As shown, it specifically includes the following steps:

[0063] S11: Synthesis of magnetic ferroferric oxide (Fe 3 o 4 )Nanoparticles

[0064] 0.665gFeCl 3 ·6H 2 O, 1.80g of sodium acetate, 0.5g of PEG1000 and 20mL of ethylene glycol were placed in the Teflon liner of a 25mL reactor, dispersed evenly by ultrasonic waves, tightened the reactor, and placed in an oven at 180°C for 8 hours. After cooling to room temperature after the reaction, the magnetic Fe3O4 nanoparticles were separated by an external magnetic field, washed with ultrapure water and ethanol until neutral, and dried in vacuum to obtain the Magnetic Fe3O4 nanoparticles.

[0065] S12: Silica-wrapped magnetic silica nanoparticles (Fe 3 o 4 SiO 2 ) preparation.

[0066] Take 0.3 g of magnetic ferric iron tetroxide nanoparticles obtained in S11 and ultrasonically disperse them into 200 mL of 80% methanol aqueous solution, add 5 mL of ammonia water and 0.7 mL of LTEOS in turn under me...

Embodiment 2

[0071]This implementation includes the following steps

[0072] S21: Synthesis of magnetic ferroferric oxide (Fe 3 o 4 )Nanoparticles

[0073] 0.945gFeCl 3 ·6H 2 O, 2.87g of sodium acetate, 0.8g of PEG1000 and 20mL of ethylene glycol were placed in the Teflon liner of a 25mL reactor, dispersed evenly by ultrasonic waves, tightened the reactor, and placed in an oven at 180°C for 8 hours. Cool to room temperature after the reaction, use an external magnetic field to collect the magnetic Fe3O4 nanoparticles, wash with ultrapure water and ethanol until neutral, and dry in vacuum to obtain Fe3O4 nanoparticles.

[0074] S22: Silica-modified magnetic silica nanoparticles (Fe 3 o 4 SiO 2 ) preparation

[0075] Take 0.45g of magnetic nanoparticles obtained in S21 and ultrasonically disperse them into 250mL of 80% ethanol aqueous solution, add 5mL of ammonia water and 1.0mLTEOS in turn under mechanical stirring, continue mechanical stirring at 40°C for 12h, use a magnet to separ...

Embodiment 3

[0080] This embodiment includes the following steps

[0081] S31: Synthesis of magnetic ferroferric oxide (Fe 3 o 4 )Nanoparticles

[0082] 0.810gFeCl 3 ·6H 2 O, 2.21g of sodium acetate, 0.7g of PEG1000 and 20mL of ethylene glycol were placed in the Teflon liner of a 25mL reactor, dispersed evenly by ultrasonic waves, tightened the reactor, and placed in an oven at 180°C for 8 hours. Cool to room temperature after the reaction, use an external magnetic field to separate the magnetic Fe3O4 nanoparticles, wash with ultrapure water and ethanol until neutral, and dry in vacuum to obtain Fe3O4 nanoparticles.

[0083] S32: Silica-modified magnetic silica nanoparticles (Fe 3 o 4 SiO 2 ) preparation

[0084] Take 0.2g of magnetic nanoparticles obtained in S31 and ultrasonically disperse them into 200mL of 80% methanol aqueous solution, add 5mL of ammonia water and 0.4mLTEOS in turn under mechanical stirring, continue mechanical stirring at 35°C for 12h, use a magnet to separat...

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Abstract

The invention provides a preparation method for a molecular imprinting material and the molecular imprinting material prepared through the preparation method. The preparation method comprises the steps that silicon oxide is coated on the surfaces of magnetic ferroferric oxide nanometer particles, the magnetic ferroferric oxide nanometer particles are modified with gamma-(methacryloyl chloride) amino propyl trimethoxy silane to obtain magnetic ferroferric oxide nanometer particles with propenyl on the surfaces, the magnetic ferroferric oxide nanometer particles with the propenyl on the surfaces serve as carriers, estrogen receptors are simulated, functional monomers are optimized, a surface imprinting technology is adopted, and then the molecular imprinting material which can simultaneously identify seven kinds of environmental endocrine disrupting chemicals is prepared. According to the preparation method, the easy separation of a magnetic nanometer material, the good water solubility of a silicon oxide nanometer material, the specific recognition ability of molecular imprinting polymers and the surface imprinting technology are mutually combined, the preparation technology is simple, the conditions are mild, the prepared molecular imprinting material is large in adsorption capacity, fast to respond, high in magnetism, good in chemical stability and high in repeating utilization rate, and the problems that at present, multiple trace, steroid and phenol environmental endocrine disrupting chemicals are difficult to simultaneously identify, separate and enrich are solved.

Description

technical field [0001] The present invention relates to the fields of environmental chemistry, analytical chemistry, food chemistry, nanotechnology, etc., and specifically relates to a method for preparing a molecularly imprinted material and the molecularly imprinted material prepared therefrom. Background technique [0002] With the rapid development of modern industry and agriculture, the pollution and harm of environmental endocrine disruptors (Environmental Endocrine Disruptors, EDCs) have become the focus of attention of countries all over the world. The U.S. Environmental Protection Agency defines EDCs as those that interfere with the synthesis, secretion, transport, combination, reaction, and metabolism of natural hormones produced in the body to maintain their own balance and regulate development processes, thereby affecting the reproduction, reproduction, and metabolism of organisms or humans. Exogenous chemicals that affect the nervous and immune systems, etc. Mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/281B01J20/30
Inventor 王珊珊刘广洋王静金芬邵华金茂俊佘永新郑鹭飞
Owner INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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