4results about How to "Easy chemical modification" patented technology

This invention relates to nucleic acid aptamers for lipoprotein-associated phospholipase A2 (Lp-PLA2), wherein the nucleic acid aptamer is at least one of B76-2, B76-4, and B76-5, with sequences shown in SEQ ID NO.1, SEQ ID NO.2, and SEQ ID NO.3, respectively. The Lp-PLA2 aptamers provided by this invention fill a gap in the field of Lp-PLA2 aptamers and exhibit high affinity and specificity. Three aptamers with good affinity and specificity for Lp-PLA2 have been screened and verified. These aptamers can be formulated into molecular probes or used as detection reagents in methods or kits for detecting Lp-PLA2, improving accuracy. They can also be used to develop novel Lp-PLA2 biosensing methods for molecular identification, showing great application potential in the early warning of cardiovascular disease events.

The invention belongs to the field of chemical detection, and discloses a fluorescent probe P1, a preparation method thereof and application of the fluorescent probe P1 in spermidine and viscosity dual-function detection. The structural formula of the fluorescent probe P1 is shown in the specification. The recognition performance of the probe P1 in various common analytes in a DMF-HEPES buffer system is researched through a fluorescence spectrophotometer. Results show that the probe P1 has specific fluorescence recognition performance on spermidine, can overcome interference of other common analytes, and has a wide pH value application range. The probe has relatively good sensitivity on the recognition of spermidine, and the lowest detection limit is 0.213 mu M. In addition, the probe P1 has a good response effect on the viscosity of the solution, is not interfered by the polarity of the solution, and can realize quantitative detection of the viscosity. The results show that the probe P1 has wide application prospects in the fields of food safety, environmental detection and biology.

This invention discloses a triphenylamine-mediated photocatalytic isomerization method for olefins from E to Z, belonging to the field of organic synthesis technology. This invention uses triphenylamine and 4-nitrotriphenylamine, triphenylamine compounds, as photocatalysts to catalyze the E-Z isomerization of olefins. Their molecular structures have a propeller configuration, which can drive olefin configuration inversion through triplet energy transfer without the need for metal participation, achieving low-cost, highly stable, and mild E-Z isomerization of olefins. This invention is carried out at room temperature, without the need for high temperature and pressure, resulting in low energy consumption and environmental friendliness. It has a wide substrate applicability, exhibiting good catalytic activity for olefins with different substituents such as methyl, halogen, cyano, and hydroxyl groups, with product yields reaching up to 92%. The operation is simple, the reaction process is straightforward, and it is suitable for large-scale production applications.

The invention relates to the technical field of perovskite solar cells, in particular to a crown ether hole transport material, a preparation method thereof and a perovskite solar cell. According to the material, a crown ether ring is used as a core functional group, and a conjugate conductive unit and a self-assembly anchoring group are connected to form an anchoring group-conjugate skeleton-crown ether ring structure. According to the preparation method, the crown ether hole transport material is synthesized step by step through two steps of Suzuki coupling, nucleophilic substitution, Arbuzov reaction and hydrolysis reaction. The material can be accurately matched with perovskite cations, passivate surface defects and improve hole mobility and interface stability, the photoelectric conversion efficiency of a small-area device breaks through 25.5%, film forming is uniform, synthesis is easy and convenient, cost is low, large-area preparation is adapted, and the problems that an existing material is low in efficiency and poor in stability can be remarkably solved.