13results about How to "Easy chemical modification" patented technology

The invention discloses a preparation method of a high-swelling semi-interpenetrating structure hydrogel for soil water retention. The method comprises the following steps: dissolving polyvinyl alcohol (PVA) at high temperature, cooling to room temperature, and sequentially adding Arabic gum (AG) and a pre-neutralized acrylic acid (AA) solution; the preparation method comprises the following steps: adding a cross-linking agent N, N '-methylenebisacrylamide (MBA) and a photoinitiator 2-hydroxy-4'-(2-hydroxyethoxy)-2-methyl propiophenone (Irgacure 2959) into a mixed solution, fully mixing, carrying out ultrasonic oscillation, and finally completing a polymerization reaction under ultraviolet irradiation to prepare the hydrogel. The method is simple in preparation process and convenient to operate, and the prepared hydrogel shows efficient water absorption capacity and a long-term water retention effect and can continuously provide required moisture for plant growth. After the gel is used for many times, the gel can still maintain good swelling performance, and the service life is prolonged. The hydrogel disclosed by the invention is suitable for the application fields of water absorption and retention in agriculture and the like.

The invention provides a protein degradation targeting chimera based on G-quadruplex RNA (Ribonucleic Acid) as well as a preparation method and application of the protein degradation targeting chimera. The structural general formula of the protein degradation targeting chimera is G-L-E, wherein G is G quadruplex RNA specifically combined with mammal fragile X hypophrenia protein (FMRP), E is a ligand of micromolecule E3 ubiquitination ligase, and L is a connecting arm between the G quadruplex RNA and the ligand of the micromolecule E3 ubiquitination ligase. The protein degradation targeting chimera provided by the invention has the advantages that the stability in an in-vivo environment and the capability of entering cells are greatly improved, and the protein degradation targeting chimera also has the capabilities of efficiently degrading FMRP and changing a secretion mode of cancer cells, so that a lot of convenience is provided for the development of nucleic acid PROTAC drugs.

The invention discloses a Ce-MOF enzyme antibacterial agent and a preparation method thereof. The preparation method comprises the following steps: dispersing Ce-MOF powder in deionized water to obtain a suspension; adding sodium hydroxide and hydrogen peroxide into the suspension, and mixing and oxidizing for 1-5 minutes; centrifugally washing and freeze-drying to obtain yellow powder in a mixed valence state; the particle size range of the yellow powder is 300 to 700 nm; the concentration range of the sodium hydroxide in the suspension liquid is 0.03 mol / L to 0.05 mol / L; the concentration range of the hydrogen peroxide in the suspension liquid is 2-3 mmol / L; the Ce-MOF is further oxidized, so that the content ratio of Ce < 3 + > to Ce < 4 + > in the Ce-MOF is changed, and the enzyme-like activity of the Ce-MOF is further improved.

This invention relates to nucleic acid aptamers for lipoprotein-associated phospholipase A2 (Lp-PLA2), wherein the nucleic acid aptamer is at least one of B76-2, B76-4, and B76-5, with sequences shown in SEQ ID NO.1, SEQ ID NO.2, and SEQ ID NO.3, respectively. The Lp-PLA2 aptamers provided by this invention fill a gap in the field of Lp-PLA2 aptamers and exhibit high affinity and specificity. Three aptamers with good affinity and specificity for Lp-PLA2 have been screened and verified. These aptamers can be formulated into molecular probes or used as detection reagents in methods or kits for detecting Lp-PLA2, improving accuracy. They can also be used to develop novel Lp-PLA2 biosensing methods for molecular identification, showing great application potential in the early warning of cardiovascular disease events.

The invention belongs to the technical field of aggregation-induced emission materials, and particularly relates to a fluorescent metal organic framework / cellulose nanocrystal composite material as well as a preparation method and application thereof. The preparation method of the fluorescent metal organic framework / cellulose nanocrystal composite material comprises the following steps: mixing a zinc acetate solution, a tetra (4-carboxybenzene) ethylene solution, nitric acid and a suspension of CNCs, and carrying out solvothermal reaction to obtain the fluorescent metal organic framework / cellulose nanocrystal composite material, the mass ratio of the zinc acetate to the tetrakis (4-carboxybenzene) ethylene to the CNCs is (10-100): (5-100); the mass ratio of the tetra (4-carboxybenzene) ethylene to the CNCs is (5-20): (0.1-5). The fluorescent metal organic framework / cellulose nanocrystal composite material prepared by the preparation method provided by the invention is good in dispersity in water, has an aggregation-induced emission effect and is excellent in sensing performance.

The present invention relates to a reprogramming responsive intelligent hydrogel material and a preparation method and application thereof. The hydrogel material provided by the present invention uses alginate as a skeleton, and uses RGD series polypeptides and polyglutamic acid to modify the skeleton respectively. The iPS cell line obtained by using the hydrogel material provided by the present invention to mediate somatic cell reprogramming is similar to embryonic stem cells, showing high expression of pluripotency-related genes at the transcriptional level and translational level, strong positive staining of alkaline phosphatase, and demethylation patterns of promoter regions of endogenous pluripotency-related genes Oct4 and Nanog. The hydrogel material provided by the present invention can quickly and efficiently obtain individual-specific induced pluripotent stem cells, laying a foundation for the acquisition of individual-specific induced pluripotent stem cells and their wide application in the fields of regenerative medicine, disease simulation and drug screening.

The invention discloses a narrow half-peak width platinum complex phosphorescent material based on regulation and control of charge density of coordination carbon atoms of a coumarin skeleton and a preparation method thereof, the structural general formula of the material is # imgabs0, regulation and control of the charge density of the coordination carbon atoms can be realized by a CN chelating ligand isomer synthesized by the coumarin skeleton, so that adjustment of MLCT components in an emission spectrum of a platinum complex is realized, and a narrow emission half-peak width and a wide emission spectrum are obtained. The requirement of the current BT.2020 wide color gamut is better met, and a core light-emitting material is provided for an OLED to meet ultrahigh-strength display; dual regulation and control of the emission color and the emission half-peak width of the platinum complex are achieved by regulating and controlling the charge density of coordinated carbon atoms in the coumarin-containing skeleton ligand, the variety of coordinated nitrogen heterocycles is further changed, comprehensive coverage from blue light to near-infrared emission color is achieved, the skeleton containing carbon, oxygen and hydrogen has high stability and rigidity, and the coumarin-containing skeleton ligand can be applied to the field of organic light emitting devices. The compound is an ideal skeleton for developing a practical high-performance narrow-half-peak-width platinum complex phosphorescent material, and has the characteristics of simple synthesis and easy functionalization.

The invention discloses a preparation method of a high-fluorescence quantum yield ultra-large blue light perovskite nanosheet. The preparation method comprises the following steps: S1, preparing a precursor solution A; s2, preparing a precursor solution B; s3, synthesizing a perovskite nanosheet; s4, passivating surface defects of the nanosheets; and S5, purifying the perovskite nanosheet. The large-size planar structure of the super-large perovskite nanosheet enables the super-large perovskite nanosheet to have better optical performance stability in some applications. Higher predictability and stability are shown in the aspects of optical and electrical properties. A crystal structure of a quantum dot is relatively complex, and due to the fact that the crystal structure is small in size, the surface effect and the quantum confinement effect are more remarkable, instability of the crystal structure and uncertainty of performance are possibly caused. The oversized perovskite nanosheet can reduce the adverse effects to a certain extent, and provides more reliable performance. The surface of the oversized perovskite nanosheet is relatively flat, and surface modification and functionalization are facilitated.

The invention belongs to the field of chemical detection, and discloses a fluorescent probe P1, a preparation method thereof and application of the fluorescent probe P1 in spermidine and viscosity dual-function detection. The structural formula of the fluorescent probe P1 is shown in the specification. The recognition performance of the probe P1 in various common analytes in a DMF-HEPES buffer system is researched through a fluorescence spectrophotometer. Results show that the probe P1 has specific fluorescence recognition performance on spermidine, can overcome interference of other common analytes, and has a wide pH value application range. The probe has relatively good sensitivity on the recognition of spermidine, and the lowest detection limit is 0.213 mu M. In addition, the probe P1 has a good response effect on the viscosity of the solution, is not interfered by the polarity of the solution, and can realize quantitative detection of the viscosity. The results show that the probe P1 has wide application prospects in the fields of food safety, environmental detection and biology.

The invention belongs to the technical field of pollutant catalysis, and provides a manganese dioxide nanofiber catalyst with a hollow structure as well as a preparation method and application of the manganese dioxide nanofiber catalyst. The method comprises the following steps: mixing manganese acetylacetonate, N, N-dimethylformamide and polyacrylonitrile, carrying out electrostatic spinning on a precursor solution, and drying to obtain a metal-polymer nanofiber membrane; the nanofiber membrane is subjected to pre-oxidation treatment and high-temperature pyrolysis, Mn / N-carbon nanofiber and potassium permanganate are mixed and then ground, the mixture, water and concentrated sulfuric acid react, and the manganese dioxide nanofiber catalyst with the hollow structure is obtained. The Mn / N-carbon nanofiber template disclosed by the invention has the characteristics of uniform structure, uniform element distribution and the like, and further chemical modification is facilitated; the MnO2 (at) Mn-CNF catalyst has a distinct hollow structure, and the generated MnO2 nanorods are in a directional growth state along the properties of the carbon fibers, so that the defect that the manganese dioxide nanoparticles are easy to agglomerate is overcome.

This invention discloses a triphenylamine-mediated photocatalytic isomerization method for olefins from E to Z, belonging to the field of organic synthesis technology. This invention uses triphenylamine and 4-nitrotriphenylamine, triphenylamine compounds, as photocatalysts to catalyze the E-Z isomerization of olefins. Their molecular structures have a propeller configuration, which can drive olefin configuration inversion through triplet energy transfer without the need for metal participation, achieving low-cost, highly stable, and mild E-Z isomerization of olefins. This invention is carried out at room temperature, without the need for high temperature and pressure, resulting in low energy consumption and environmental friendliness. It has a wide substrate applicability, exhibiting good catalytic activity for olefins with different substituents such as methyl, halogen, cyano, and hydroxyl groups, with product yields reaching up to 92%. The operation is simple, the reaction process is straightforward, and it is suitable for large-scale production applications.

The invention belongs to the field of biomass aerogel materials, and particularly relates to a preparation method and application of a nanocellulose aerogel photocatalyst. The invention discloses a nanocellulose aerogel composite material. The nanocellulose aerogel composite material comprises a titanium dioxide-bismuth trioxide heterojunction which is uniformly loaded and distributed. According to the preparation method disclosed by the invention, a hydroxyl functional group on nano-cellulose and an aldehyde group on a glutaraldehyde cross-linking agent are subjected to aldol condensation reaction, so that the nano-cellulose aerogel with chemical stability is obtained. The composite material provided by the invention can effectively inhibit compounding of photo-induced electrons and holes, and due to the advantages that the cellulose aerogel is large in aperture, can inhibit agglomeration of heterojunction powder and the like, the visible light utilization rate of the material is increased, and the photocatalytic performance of the material is improved. Furthermore, experimental condition optimization and a series of contrast experiments are carried out on photocatalytic degradation of tetracycline, and the conditions such as pH and concentration which are most beneficial to the composite material disclosed by the invention during photocatalytic degradation of tetracycline are discussed.

The invention relates to the technical field of perovskite solar cells, in particular to a crown ether hole transport material, a preparation method thereof and a perovskite solar cell. According to the material, a crown ether ring is used as a core functional group, and a conjugate conductive unit and a self-assembly anchoring group are connected to form an anchoring group-conjugate skeleton-crown ether ring structure. According to the preparation method, the crown ether hole transport material is synthesized step by step through two steps of Suzuki coupling, nucleophilic substitution, Arbuzov reaction and hydrolysis reaction. The material can be accurately matched with perovskite cations, passivate surface defects and improve hole mobility and interface stability, the photoelectric conversion efficiency of a small-area device breaks through 25.5%, film forming is uniform, synthesis is easy and convenient, cost is low, large-area preparation is adapted, and the problems that an existing material is low in efficiency and poor in stability can be remarkably solved.