93 results about "Michael reaction" patented technology

The invention provides a graphene / polysiloxane composite coating material and a preparation method thereof. The method comprises the following steps: modifying the graphene surface with active groups by a chemical modification technique to obtain modified graphene, mixing the modified graphene with a silane compound, a dispersion medium, a non-essential comonomer and a non-essential accelerator, and carrying out hydrolytic condensation or hydrolytic condensation-free radical polymerization to generate a graphene / polysiloxane composite resin in situ; and mixing the resin with a non-essential blend resin, a non-essential curing agent, a non-essential solvent, a non-essential pigment and filler and a non-essential aid, and carrying out physical blending, amino epoxy addition reaction, Michael addition reaction and the like to form a film, thereby obtaining the graphene / polysiloxane composite coating material. The uniformly dispersed graphene lamellae and polysiloxane have strong interface effects, also have the gas / liquid barrier and heat shielding effects, and endow the coating with excellent corrosion resistance, flame retardancy and the like, thereby greatly enhancing the mechanical properties, corrosion resistance, scratch resistance, wear resistance and the like of the coating.

A curable composition for electrical applications, the curable composition comprising (i) a compound having at least two alpha,beta-unsaturated groups and an equivalent weight of less than 250 g / mol, (ii) a catalyst capable of initiating a Michael reaction and (iii) a Michael donor having an equivalent weight of less than 250 g / mol, and a package for using this composition in electical splices.

Disclosed is a photosensitive composition for volume hologram recording which shows excellent interference fringe record and a volume hologram recording medium having lighter weight and excellent storage stability. The invention is directed to a volume hologram recording photosensitive composition comprising: (a) a compound having at least one active methylene group in one molecule or a compound having at least two active methine groups in one molecule; (b) a compound containing in one molecule two or more groups which are nucleophilicly added by a carbanion generating from an active methylene group or an active methine group; (c) a Michael-reaction catalyst; (d) a photopolymerizable compound; and (e) a photopolymerization initiator composition.

The invention discloses preparation and an application of an MOF (metal organic framework) modified nanofiltration / reverse osmosis membrane and belongs to the technical field of preparation of water treatment membranes. Firstly, a dopamine bio-inspired material is subjected to an auto-agglutination reaction to uniformly coat the surface of a polymer support layer, then, MOF is assembled on the surface of the porous support layer in advance through a Michael addition reaction or a Schiff base reaction between MOF and the coating layer, and then, an interface polymerization reaction is conducted, so that the MOF material is embedded in a PA (polyamide) active layer. The preparation and the application have the advantages that the problems that the MOF is mixed in water phases or organic phases traditionally and MOF is not uniformly dispersed in the PA layer are solved, and meanwhile, the dosage of the MOF can be greatly reduced. The retention rate is well kept while the membrane flux ofthe prepared MOF modified nanofiltration / reverse osmosis membrane is improved. The method is simple and easy to operate and has broad application prospects.

The invention discloses a synthetic method for a beta-aminocarbonyl compound, beta-mercapto ketone and beta-alkoxy ketone. In the method, ionic liquid is used as a catalyst, and aza-Michael, sulfa-Michael and oxa-Michael reactions of electron-deficient ketene and a nucleophilic reagent are carried out at room temperature so as to synthesize corresponding compounds. According to the invention, usage amount of the catalyst is small, and the catalyst has the advantages of high catalytic activity, good stability, low corrosivity, cyclical usability, good selectivity of products, simple operation and strong controllability; a substrate has a wide application scope, and good yield is obtained in addition of alcohol compounds with low reaction activity; the reactions are mild; reaction products and the catalyst can be easily separated, and the catalyst can be cyclically used.

The present invention relates to amino group-containing chiral ionic liquid and its preparation process and application in organic asymmetrical catalytic Michael reaction. The chiral ionic liquid has the general expression of A+B-, A+ is shown, and B- is halogen ion or other negative ions as shown. The preparation process includes the following steps: the reflux reaction between amino acid derived halogenated fatty amine haloid and substituting imidazole in organic solvent, and the neutralization of the reacted liquid to obtain the product. The chiral ionic liquid with connected imidazole cycle possessing excellent stereo steric hindrance effect has excellent chiral catalytic performance on Michael reaction except its application as common ionic liquid.

The invention discloses a method for assembling nano-particles carrying laminin and SDF-1alpha on surfaces of Ti materials. The method comprises the steps that firstly, Hep-PLL nano-particles carrying Ln are prepared; then DM coatings are prepared on the surfaces of angiocarpy materials, nano-particles including amidogen are fixed to surfaces of samples in a covalence mode through the characteristics that DM and the amidogen can generate the Michael reaction and the Sievert reaction; finally, through the characteristics that heparin in the nano-particles can be specially bound with the SDF-1alpha, the SDF-1alpha is assembled to the surfaces of the nano-particles, and therefore multifunctional bioid modification surfaces with anticoagulation, hyperplasia prevention and endothelium regeneration inducing characteristics are constructed. According to the method, the nano-particle modification layers with the anticoagulation, hyperplasia prevention and endothelium regeneration inducing characteristics are constructed on the surfaces of the angiocarpy materials, the blood compatibility and endothelium and endothelial progenitor cell compatibility of the materials are obviously improved, and the capacity of restraining smooth muscle hyperplasia is enhanced.

The present invention is directed to a process of making α-aminooxyketone and α-hydroxyketone compounds. The synthetic pathway generally involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence of a catalyst of the formula (IV): wherein Xa—Xc represent independently nitrogen, carbon, oxygen or sulfur and Z represents a 4 to 10-membered ring with or without a substituent and optionally a further step to convert the α-aminooxyketone compound formed to the α-hydroxyketone compound. The present invention results in α-aminooxyketone and α-hydroxyketone compounds with high enantioselectivity and high purity. The present invention is also directed to a catalytic asymmetric O-nitroso Aldol / Michael reaction. The substrates of this reaction are generally cyclic α,β-unsaturated ketone substrate and a nitroso substrate. This methodology generally involves reacting the cyclic α,β-unsaturated ketone substrate and the nitroso substrate in the presence of a proline-based catalyst, to provide a heterocyclic product.

The present invention is to provide a curable coating composition having much less of a volatile organic component, and being excellent in coating film performance such as durability and scratch resistance, and a coating film forming method using the above curable coating composition capable of suppressing generation of sagging and so on. The present invention is a curable coating composition which comprises (a) a component having an active methylene group and / or an active methine group, (b) a component having a methacrylate group and / or an acrylate group, (c) a Michael reaction catalyst and (d) a photo-polymerization initiator. The present invention also provides a coating film forming method which comprises a step (1) of applying a curable coating on a substrate to be coated and a step (2) including a stage of irradiating with ultraviolet ray and a stage of heating, said curable coating comprising the above curable coating composition.

The invention discloses a glutathione response-type dual-drug carrier as well as a preparation method and application thereof, and belongs to the field of biomedical engineering materials. The preparation method comprise the following steps: performing Michael addition reaction to obtain hyperbranched poly(amide amine)s; then connecting a hydrophobic drug onto an end group amino of a high polymer by amidation reaction, so as to form a prodrug micelle molecule; then loading another hydrophobic drug by subject-object assembly of the prodrug micelle molecule, thus effectively increasing drug loading capacity and promoting an synergistic effect of the drugs; preparing to obtain the glutathione response-type dual-drug carrier. The method is mile, the operation is convenient, byproducts are fewer, and a product is easy to separate and purify, thus facilitating the material biocompatibility. The glutathione response-type dual-drug carrier has the advantages of simple material components, easy-to-get raw materials and good biocompatibility, and is hopefully widely applied to the field of the biomedical engineering materials as a great amount of surface functional groups capable of being modified provide support for the application of the carrier in preparing the biomedical engineering materials.

The invention discloses a 13-thioether substituted pleocidin derivative which is represented by a general formula (I) shown in the specification and has an insecticide and acarid-killing activity, and a preparation method thereof. The compound with the general formula (I) is obtained by a chemical synthesis method from natural pleocidin or a pleocidin derivative prepared by a semi-synthesis method as a raw material. The synthesis method disclosed by the invention comprises a 13-Michael reaction, an acylation reaction and an esterification reaction. The compound with the general formula (I) has good activity on various pests and acarids on crops. The compound with the general formula (I) is prepared into an acid addition salt by using a standard salt preparation technology to be used for crop protection.

The invention relates to a chiral nitrogen-containing heterocyclic compound, and a synthesis method and application thereof. The nitrogen-containing heterocyclic compound can be a chiral pyrrolidine compound, chiral piperidine compound or chiral morpholine compound which is synthesized by carrying out intramolecular aza Michael reaction on chiral phosphoric acid or chiral thiocarbamide-catalyzed cyclohexadiene ketone derivatives in a high-efficiency high-enanatioselectivity mode. The nitrogen-containing heterocyclic compound can be used for preparing alkaloid (-)-Mesembrine. The method has the advantage of mild reaction conditions and is simple to operate. In addition, no metallic salt compound is added in the reaction, thereby being beneficial to production and treatment of potential bioactive compounds. The reaction yield is high (generally 73-97%), and the enanatioselectivity is high (generally 89-99%).

The invention discloses a preparation method of a non-viral gene vector material. The method comprises the following steps of: performing michael reaction on polyol acrylate and amino alcohol to prepare an unmodified polymer; and reacting the unmodified polymer with a diamino group containing compound to prepare an ester bond-containing non-viral gene vector material. The method has the characteristics of easiness in preparation and high controllability; and the prepared non-viral gene vector material has the characteristics of high efficiency and low toxicity. The invention discloses application of the non-viral gene vector material to transfection of cells; and the application comprises the following steps of: mixing the non-viral gene vector material and genes; incubating to prepare a compound of a non-viral gene vector and a gene; and adding the prepared compound of the non-viral gene vector and the gene into receptor cells to finish the transfection of the genes in the cells. Thecompound of the non-viral gene vector and the gene has high gene transfection efficiency and superior biological safety for the transfection of the cells.

The invention discloses a pluridentate macromolecular bonding agent and a preparation method thereof. The structural formula of the bonding agent is as shown in (I). The preparation method of the bonding agent particularly comprises the following steps: taking tris(2-hydroxyethyl)isocyanurate and glycidyl methacrylate as raw materials; synthesizing pluridentate polyether ester with an unsaturated end group under the action of a catalyst; dissolving intermediate polyether ester with a solvent, introducing such functional groups as the hydroxyl group, the secondary amine group, aziridine and methyl aziridine by carbon-carbon double bonds of polyether ester and the Michael reaction of a primary amine compound or a secondary amine compound to obtain the pluridentate macromolecular bonding agent. The pluridentate macromolecular bonding agent is simple in preparation technology and easily accessible in raw material, and can be applied to the field of solid propellants. The structural formula (I) is as shown in the description, wherein X, Y and Z are 1, 2, 3, 4 and 5, and R is as shown in the description.

The present invention discloses a quaternary phosphonium salt compound and a preparation method thereof. The method uses cheap and readily available L-tartaric acid as the raw material, and conducts carboxyl esterification, hydroxyl protection, Grignard reaction, azide substitution, azide reduction and final reaction with phosphorus pentachloride, so as to obtain the quaternary phosphonium salt compound. The quaternary phosphonium salt compound is a novel Bronsted acid catalyst (a hydrogen bond donor catalyst), and can be used in the catalysis of asymmetric Mannich reaction, Michael reaction and Henry reaction.

The invention discloses a water-soluble copper ion fluorescent probe and a preparation method thereof and belongs to the technical field of chemical synthesis and analytical chemistry. The chemical name of the water-soluble copper ion fluorescent probe disclosed by the invention is N-n-butyl-4-[ethylenediamine-2-N,N'-di(3-propionic acid)]-1,8-naphthalimide; a synthesis method of the water-soluble copper ion fluorescent probe comprises the following steps: firstly, carrying out amidation on 4-bromo-1,8-naphthalic anhydride and n-butylamine; replacing 4-site bromine with ethylenediamine; then carrying out Michael reaction on a product of the last step and methyl acrylate; finally, carrying out alkaline hydrolysis and treating through a cation exchange column to obtain the copper ion fluorescent probe. An experiment shows that the probe can be used for selectively detecting copper ions and has fluorescent quenching in a DMSO / HEPES (Dimethyl Sulfoxide / 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffering system; the copper ions are quantitatively detected; the water-soluble copper ion fluorescent probe has high detection sensitivity and the identification is not interfered by other ions, so that the copper ion fluorescent probe can be used for detecting heavy metal ions and is especially used for detecting the copper ions in biological tissues and environment sewage.

The present invention is to provide a curable coating composition having much less of a volatile organic component, and being excellent in coating film performance such as durability and scratch resistance, and a coating film forming method using the above curable coating composition capable of suppressing generation of sagging and so on. The present invention is a curable coating composition which comprises (a) a component having an active methylene group and / or an active methine group, (b) a component having a methacrylate group and / or an acrylate group, (c) a Michael reaction catalyst and (d) a photo-polymerization initiator. The present invention also provides a coating film forming method which comprises a step (1) of applying a curable coating on a substrate to be coated and a step (2) including a stage of irradiating with ultraviolet ray and a stage of heating, said curable coating comprising the above curable coating composition.

In a non-limiting embodiment, there is provided a compound of formula (I), which may permit for a method or use in treating or preventing a cancer, such as pancreatic cancer or leukemia. In one embodiment, there is also provide a method of preparing a compound of formula (Ia), the method including conducting a cyclization reaction of a compound of formula (III) to obtain a compound of formula (IV), wherein conducting the cyclization reaction comprises conducting a Michael reaction in the presence of a Lewis acid.

The invention discloses a polymer with an anti-cancer property and a preparation method and application of the polymer, and belongs to the field of biomedical engineering materials. Hyperbranched polyamidoamine which contains disulfide bonds is obtained by Michael reaction; and growth of tumor tissue cells is inhibited by inherent pharmacological activity of the hyperbranched polyamidoamine, but the hyperbranched polyamidoamine does not have side effects on normal tissue cells. The preparation method is gentle, and is convenient to operate, by-products are less, products are easy to separate and purify, and biological compatibility of the material is facilitated. The polymer with the anti-cancer property is simple in material component, has easily obtained raw materials and is good in biological compatibility, has obvious curative effect when independently used as a potential anti-tumor drug, and does not need to be loaded with drugs additionally; and a large number of modifiable functional groups on the surface of the polymer support application of the polymer in preparation of the biomedical engineering materials, and the polymer with the anti-cancer property is expected to be widely applied to the field of biomedical engineering materials.

The present invention discloses a silane compound and a preparation method thereof, and a translucent dealcoholization type room temperature curing silicon rubber and a preparation method thereof. According to the present invention, amino-containing alkoxysilane and polyfunctional acrylate are subjected to a Michael addition reaction at a high temperature to synthesize novel alkoxysilane having a secondary amine structure and an ester structure, and the translucent dealcoholization type room temperature curing silicon rubber prepared by using the novel silane compound has characteristics of excellent storage stability, excellent adhesion with most substrates, especially polycarbonate, aluminum, copper and the like, and the like.

The invention discloses a porous organic polymer linked by a thiourea structure as well as a preparation method and an application of the porous organic polymer. The preparation method comprises the following steps: adding a compound II and a compound III to an organic solvent under argon or nitrogen atmosphere, and uniformly dispersing the compound II and the compound III by ultrasonic at room temperature; after freezing and deoxidizing, heating the mixture to 60-120 DEG C for a reaction for 24-72 hours; then, cooling the reaction product to room temperature, adding acetone to a reaction solution, performing stirring for 1-2 hours, and performing filtering, washing and drying to obtain the porous organic polymer POP-S linked by the thiourea structure. The synthesized porous organic polymer catalytic material linked by the thiourea structure has more thiourea structures in unit pore channels, can efficiently catalyze Michael reaction between beta-nitrostyrene and diethyl malonate on the basis of dihydrogen bond interaction of thiourea in POP-S as a catalytic active center, and has good solvent tolerance, stability and recyclability.

A process for preparing optically active nitro compounds and cyano compounds represented by the chemical formula (C) using a metal complex, which is obtained by reaction of an optically active nitrogen-containing compound and a periodic table group VIII metal complex, in the asymmetric Michael reaction of a compound represented by the chemical formula (A) and a compound represented by the chemical formula (B) according to the claim 1.

The invention relates to a two-component bonding agent system, consisting of a component A and a component B, comprising A) at least one polymer that possesses at least one Michael acceptor group, and in addition at least one Michael donor group, B) a compound catalyzing the Michael reaction, as well as optional additional additives and / or auxiliaries, wherein the polymer of component A has a number average molecular weight (Mn) between 1000 g / mol and 1 000 000 g / mol. Furthermore, 2K-adhesives, casting compounds and coating agents made from such bonding agent systems are described.

The present invention relates to a method for the preparation of morphine compounds comprising a low content of alpha,beta-unsaturated compounds, which comprises the steps of: (i) bringing the crude morphine compound into contact with a base, at a pH of greater than 13, under conditions which make possible the Michael addition reaction on the alpha,beta-unsaturated compound(s) present; (ii) separating the morphine compound from the reaction mixture; and (iii) if appropriate, separating the addition product formed, from the morphine compound. It also relates to a composition comprising at least 99% by dry weight of morphine compound, or of a pharmaceutically acceptable salt thereof, and an alpha,beta-unsaturated compound in a content of less than 100 ppm.

The present invention relates to a method for coating nanoparticles to achieve stable dispersions of said particles in a liquid medium and the surface functionalization thereof with groups that have physical activity such as luminescence, chemical activity such as catalytic capacity and / or biological activity such as a capacity for selectively binding with a biological entity.

Objects of the present invention are to provide an industrially applicable method for producing an optically active α-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active α,α-disubstituted α-amino acid, and to provide an intermediate useful for the above production methods of an optically active α-amino acid and an optically active α,α-disubstituted α-amino acid.The present invention provides a production method of an optically active α-amino acid or a salt thereof, the production method comprising introducing a substituent into the α carbon in the α-amino acid moiety of a metal complex represented by the following Formula (1):by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure α-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.

The invention relates to a method for preparing 1,7-diazaspiro[4.5]decane and derivatives thereof, and mainly solves the technical problems that the synthetic route is long, the yield is low, an intermediate is difficult to purify, reaction conditions are rigorous, and mass production cannot be performed in the prior art. The method comprises the following steps of: performing Michael addition reaction on N-PG-3-nitropyridine serving as a raw material and acrylic ester or acrolein in alcoholic solution or acetonitrile to obtain N-PG-3-(3-nitropyridine-3-yl)propionate or N-PG-3-propanal-3-nitropyridine; adding a catalyst into the product in an organic solvent, and performing hydrogenation reduction ring-closing reaction to obtain 1,7-diaza-2-oxy-spiro[4.5]decane with a protective group or 1,7-diazaspiro[4.5]decane with a protective group; and adding a reducing agent into the 1,7-diaza-2-oxy-spiro[4.5]decane with the protective group in the organic solvent to obtain the 1,7-diazaspiro[4.5]decane with the protective group. The method has the advantages of a few reaction steps, high yield and mild conditions, and is a synthetic method with large-scale preparation value.

The invention relates to a humus acid polyethylene glycol grafted copolymer and a preparation method thereof, and belongs to the field of modification of natural polymers. A humus acid molecule servesas a skeleton structure, peg polymer segments are covalently bonded to the side chain of the humus acid. The preparation method of the grafted copolymer comprises the steps that firstly acrylic acidesterified humus acid is prepared through acylation reaction of the humus acid and acryloyl chloride under condition of trimethylamine existing; secondly, the humus acid was esterified by acrylic acid, Michael reaction is conducted with aminopolyethylene glycol monomethyl ether to prepare a humus acid polyethylene glycol grafted copolymer coarse product; and finally, a dialysis technology is usedfor removing unreacted amino polyethylene glycol monomethyl ether and sodium hydroxide in the coarse product, a final product is obtained after drying. The humus acid polyethylene glycol grafted copolymer and the preparation method thereof have the beneficial effects that a water-soluble and non-toxic polyethylene glycol chain segment is introduced in the humus acid structure to overcome the performance defect of the poor water solubility, the product has good solubility in water, the preparation method is high in efficiency, the reaction condition is mild, using of organic solvent is avoided,and green production is easy to achieve.

The invention relates to a synthetic method of dicarbonyl sensitization resin with carbon, which comprises the steps that a polyol acrylic ester monomer and a Beta-dicarbonyl compound are mixed evenly, and then a reaction insoluble solid basic catalyst for mixing and heating is added to lead the multielement acrylic ester monomer and the Beta-dicarbonyl compound with agile methylene to act Michael reaction, and filtrating is held after finishing the reaction to lead the solid basic catalyst and the product resin to be separated. The catalysis system of the invention comprises an insolubility catalyst with alkali characteristic, such as alumina loaded with potassium fluoride and alkali negative ion exchange resin. The solid basic catalyst effectively promotes the Michael reaction and is convenient for filtrating after reaction, and the solid basic catalyst is removed from product oligomer, thereby avoiding the further influence to the product resin by an alkali catalyst to enable the storage stability of the product resin to be improved. The addition resin can realize rapid light curing under the condition of having no photo-initiator, and also can be used for photo-cured coating and printing ink blending.