42 results about "Methine group" patented technology

Disclosed is an organic EL element material represented by the following general formula (1):wherein, in the general formula (1), any one of X1 to X3 is a nitrogen atom, and others are methine groups; L1 is a substituted or unsubstituted phenylene group, a substituted or unsubstituted naphthylene group, or substituted or unsubstituted anthrylene group; L2 is single bond, a substituted or unsubstituted phenylene group, a substituted or unsubstituted naphthylene group, or a substituted or unsubstituted anthrylene group, in which when these groups are substituted, the substituent is an alkyl group or an alkoxy group; A is a phenyl group or a pyridyl group; and n is 0 or 1. An organic EL element excellent in luminance efficiency and durability life is provided.

Provided is a photosensitive resin composition having excellent low-temperature curability and capable of providing a cured resin film having sufficient solvent resistance or sufficient hardness. Also, provided are a color filter having excellent solvent resistance or excellent hardness, and an image display element having same. A photosensitive resin composition according to the present invention contains a copolymer (A), a reactive diluent (B), a photopolymerization initiator (C), and a solvent (D).　The copolymer (A) contains a structural unit (a), a structural unit (b), and a structural unit (c). The structural unit (a) has at least one selected from among an active methylene group having an alkoxycarbonyl group attached thereto, and an active methine group having an alkoxycarbonyl group attached thereto. The structural unit (c) has an acid group.

The invention relates to heteroaromatic super absorbent resin and a preparation method thereof, and belongs to the technical field of polymer synthesis. The invention provides heteroaromatic super absorbent resin. The structural formula of the heteroaromatic super absorbent resin is shown as a formula I, the heteroaromatic ring super absorbent resin does not contain a methine structure, contains more heteroaromatic ring structures, and is good in thermal stability. # imgabs0 #

Provided is a compound represented by general formula (1). In formula (1), X1 and X2 are each independently selected from the group consisting of a methine group and a nitrogen atom, n is an integer of 0-3, R1 and R2 are each independently a hydrogen atom, a halogen atom, or a monovalent organic group, R1 and / or R2 is a monovalent organic group having a Hammett substituent constant σp of 0.50 or greater, and the adjacent R1 and R2 moieties may be a part of a fused ring, the fused ring optionally including one or more atoms other than carbon.

[Problem] To provide a substance having an activity of antagonizing the binding of histamine to histamine-H3 receptor, or having an activity of inhibiting the homeostatic activity of histamine-H3 receptor. [Means for Solution] A compound of the following formula (I) is provided: [wherein X, Y, Z and W each independently represent a methine group optionally having 1 or 2 substituents, or a nitrogen atom (provided that a case where all of X, Y, Z and W are an optionallysubstituted methine group); A, B and D represent C(0)-, etc.; Q represents a methine group or a nitrogen atom; R represents an optionallysubstituted group of the following formula (II-1): (wherein R7 and R8 each independently represent a lower alkyl group, etc.)].

The invention discloses a thiophenol-heptamethine cyanine dye derivative as well as self-assembled nanoparticles, a preparation method and application thereof. The derivative is a thiophenol-heptamethine cyanine dye monomer derivative or a 1, 3, 5-benzene trithiophenol-heptamethine cyanine dye triad derivative; the thiophenol or the 1, 3, 5-benzene trithiophenol is connected with a meso-carbon atom of the heptamethine cyanine dye through a sulfur atom, and the heptamethine cyanine dye is formed by connecting two nitrogen-containing heterocyclic ring units through a conjugated methine chain; the nanoparticles are obtained by dropwise adding a derivative solution into water and then removing an organic solvent. The synthesis method of the thiophenol-cyanine dye derivative is simple and easy to implement, stable nanoparticles can be formed, the tumor targeting property can be improved, the aggregation effect far better than that driven by traditional weak interaction is achieved, synchronous optimization of high tumor accumulation and extremely high heat production efficiency is successfully achieved through self-assembly of nanoparticles, and the thiophenol-cyanine dye derivative has good application prospects. An innovative strategy is provided for the development of a high-performance tumor photo-thermal reagent.

The invention relates to the technical field of medicine preparation, in particular to a medroxyprogesterone acetate production process, which comprises the following steps: adding 182.4 kg of N, N-dimethylformamide into a reaction kettle through a head tank, then extracting 60 kg of cyclohexene, adding the cyclohexene into the reaction kettle through the head tank, starting the reaction kettle, starting to stir and mix in the reaction kettle, adding the cyclohexene into the reaction kettle through the head tank, adding the cyclohexene into the reaction kettle through the head tank; adding 40kg of methine into the reaction kettle through a feeding port, introducing nitrogen, continuously stirring for 30 minutes, weighing 2kg of palladium-carbon, adding into the reaction kettle through a feeding port, stopping introducing nitrogen, slowly heating in a steam bath of the reaction kettle, controlling the internal temperature to 110 + / -2 DEG C, distilling for 60 minutes under normal pressure, controlling the internal temperature of the reaction kettle to 110 + / -2 DEG C, and refluxing for 60 minutes; according to the method, the problems that an existing medroxyprogesterone acetate production process flow is relatively complex, more intermediates exist, and the material utilization rate is relatively low can be effectively solved.

This power cable is provided with: a conductor; and an insulating layer that is provided for covering an outer periphery of the conductor and that is configured from a resin composition containing polyethylene. The insulating layer contains, among polyethylene, a crosslinked polyethylene that is insoluble in xylene at 120°C and an uncrosslinked polyethylene that can be eluted in xylene at 120° C. A methine group content in the uncrosslinked polyethylene is 0.5-3.0 per 100 carbons in the uncrosslinked polyethylene.

Provided is a polyvinyl acetal resin with which it is possible to obtain a ceramic green sheet having uniform tensile strength and high breaking point stress, in particular, when used as a binder for ceramic green sheets. The invention relates to polyvinyl acetal resin. The ratio of the peak integral value of the methine C atoms represented by (a) 'in the triad units represented by formula (a) obtained by 13C-NMR (nuclear magnetic resonance) measurement to the total of the peak integral values of the methine C atoms represented by (a) ', (b)', and (c) 'in the triad units represented by formula (a), formula (b), and formula (c) is less than 0.23; the polyvinyl acetal resin has a weight-average molecular weight of 230,000 or more, and the half-value width of a peak observed within a retention time range of 20-30 minutes in a high performance liquid chromatography (HPLC) measurement is 0.50 or less. In formula (b) and formula (c), each R independently represents a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms. # imgabs0 #

A compound represented by formula (I) (wherein each X is independently a methine group or a nitrogen atom, n is an integer of 0-3, each R1-R5 is independently a hydrogen atom, a halogen atom, a cyano group, a linear, branched or cyclic alkyl group, or the like, each R6-R7 is independently a hydrogen atom, a halogen atom other than a fluorine atom, a cyano group, a linear, branched or cyclic alkyl group, or the like, and n is an integer of 0-3. And one or more of R1-R5 and one or more of R6-R7 are a halogen atom or a monovalent organic group having a Hammett substituent constant [sigma] p of 0.10 or more).

This invention discloses a method for preparing co-assembled nanoparticles of thiophenol-heptamethine dye monomer and its triplet derivative, as well as their applications. The co-assembled nanoparticles comprise thiophenol-heptamethine dye monomer and a triplet derivative. The derivative is formed by linking the sulfur atom of thiophenol to the middle carbon atom of heptamethine dye, and the heptamethine dye is formed by two nitrogen-containing heterocyclic units linked by a conjugated methylene chain. The method involves mixing solutions of the two derivatives and adding them dropwise to water, followed by removal of the organic solvent to obtain co-assembled nanoparticles with uniform particle size. This invention significantly enhances the assembly stability of the nanoparticles while successfully retaining the excellent photothermal conversion efficiency of the triplet derivative, overcoming the technical bottleneck of the difficulty in stabilizing high-heat-generating molecules into particles. It achieves synergistic optimization of the assembly stability and photothermal efficiency of photothermal reagents, providing a novel design strategy and technical support for the development of high-performance tumor photothermal therapy drugs.

The invention relates to an RMA crosslinkable polymer comprising: a) at least one RMA Donor moiety X comprising a C—H acidic proton in activated methylene or methine groups, b) at least one moiety Y comprising one or more 5- or 6-membered heterocycles containing an ether-, acetal- or ketal group which in case of two or more of such heterocycles can be fused or linked, wherein the polymer has a weight-average molecular weight Mw of at least 400 g / mol and a C—H equivalent molecular weight CH EQW of at least 80 g / mol. The invention also relates to a process for the preparation of the RMA crosslinkable polymer, to an RMA crosslinkable composition comprising the RMA crosslinkable polymer and coated substrates.

The present disclosure relates to a cyanine compound represented by formula (1). In formula (1), ring A1 and ring A2 each represents an optionally substituted aromatic hydrocarbon ring, an optionally substituted aromatic heterocyclic ring, or an optionally substituted fused ring containing these ring structures, ring B1 and ring B2 each represents a hydrocarbon ring optionally having a substituent and / or a fused ring structure, or a heterocyclic ring optionally having a substituent and / or a fused ring structure, and ring B1 and ring B2 each represents a hydrocarbon ring optionally having a substituent and / or a fused ring structure. (In the formula, R1 and R2 each represent an organic group, L represents a methine chain, and X-represents a monovalent anion in which the pKa of the conjugated acid is-8.0 or less. # imgabs0 #

A surfactant and the use thereof, a preparation method for a fluoropolymer, and a fluoropolymer composition. The surfactant comprises a monophosphate, wherein the monophosphate contains an arylphenolic group having an alkyl chain substituent, and does not contain methyl, methylene or methine directly linked to an aromatic ring group. The surfactant does not contain methine. The methylene content of the surfactant is less than 20% in terms of the number of carbon atoms. The surface tension of a neutral aqueous solution containing 1 wt% of the surfactant is 26 mN / m to 31 mN / m.

The invention discloses a method for preparing metacycline hydrochloride with low impurity content by directly neutralizing a 11a-chloro-6-methylenetetracycline solution serving as a raw material, and belongs to the technical field of chemical engineering. The method comprises the following steps: adding a neutralizer into a 11a-chlorine-6-methine oxytetracycline solution for neutralization treatment, and filtering to obtain a 11a-chlorine-6-methine oxytetracycline neutralization solution; the method comprises the following steps: adding a 11a-chlorine-6-methyleneoxytetracycline neutralization solution and a regenerated palladium-carbon catalyst into an alcoholic solution, carrying out temperature-controlled hydrodechlorination reaction, filtering, adding sulfosalicylic acid into filtrate, and crystallizing to form salt, so as to obtain the methyleneoxytetracycline, and reacting methyleneoxytetracycline with hydrochloric acid, crystallizing, filtering, and drying to obtain the metacycline hydrochloride. According to the method, a 11a-chloro-6-methyleneoxytetracycline salifying process is not carried out, and the purity and quality of a metacycline hydrochloride product are improved while the production cost is reduced by simplifying a synthetic route, optimizing a process and reducing emission of three wastes (waste gas, waste water and industrial residues).

Provided is a surface protective film including an adhesive layer. The surface protective film exhibits sufficiently strong adhesiveness to an adherend before ultraviolet irradiation, and once being subjected to ultraviolet irradiation, demonstrates excellent effortless peelability, allowing easy separation from the adherend. Furthermore, the surface protective film has superior storage stability.　A surface protective film according to an embodiment of the present invention includes an adhesive layer. An adhesive constituting the adhesive layer is formed from an adhesive composition. The adhesive composition contains a urethane prepolymer (A), a crosslinking agent (B), a photopolymerization initiator (C), and an antioxidant (D). The urethane prepolymer (A) includes: an alkylene oxide skeleton including two groups, each of which being at least one type selected from the group consisting of a methylene group and a methine group; and an alkylene oxide skeleton including three or more groups, each of which being at least one type selected from the group consisting of a methylene group and a methine group.

The invention provides a photosensitive resin composition and a photosensitive coloring composition, which have excellent developability and good low-temperature curability and can form a resin cured film with sufficient hardness and solvent resistance. The photosensitive resin composition includes a resin (A), a reactive diluent (B), a photopolymerization initiator (C), and a solvent (D). The resin (A) is an addition reaction product of a (meth) acrylic resin (a-0) containing a hydroxyl group, a compound (a-4) containing an isocyanate group and an ethylenically unsaturated group, and a polybasic acid or an acid anhydride (a-5) thereof. (a-0) is a copolymer containing a structural unit derived from a (meth) acrylate (m-1) containing a hydroxyl group and a structural unit derived from a (meth) acrylate (m-2) having one or more groups selected from the group consisting of an active methylene group, an active methine group, an epoxy group, an oxetanyl group, a blocked isocyanate group, and a silyl group.

The invention provides a clarithromycin derivative, a pharmaceutical composition and application of the clarithromycin derivative, and relates to the technical field of pharmaceutical chemistry, the clarithromycin derivative has a general formula structure as shown in the following formula I. In the formula I, W is selected from any one group of oxygen atom and NOCH2C = C-Ar, and the structural formula is shown in the description. Ar is selected from any one of pyridyl, quinolyl, isoquinolyl, substituted pyridyl, substituted quinolyl and substituted isoquinolyl; v is selected from any one of oxygen atoms and 11-site side chains of telithromycin; x is selected from any one of-C is equivalent to C-,-OCH2CH2C is equivalent to C-and piperazinyl; q is selected from any one of methylene and fluorine-substituted carbon atoms; z is selected from any one of methylene, fluorine-substituted carbon atoms, nitrogen atoms and methoxyl carbon atoms; r1 and R2 are respectively and independently selected from any one of hydrogen atoms, C1-C3 alkyl groups, halogen-substituted C1-3 alkyl groups, C3-4 cycloalkyl groups, halogen-substituted C3-4 cycloalkyl groups and halogen-substituted phenyl groups; and the value range of n is an integer between 3 and 6. # imgabs0 #

A luminescent solar concentrator (LSC) device is provided. The LSC device has an active layer including a modified luminophore having a polymethine component including a plurality of methine groups (═CH—)n, where n is an odd integer greater than 1. A hydrogen atom (H) of one of the plurality of methine groups is replaced by one of -AR1R2 or -DR3, where A is selected from nitrogen (N), phosphorus (P), arsenic (As) and antimony (Sb) and D is selected from oxygen (O), sulfur (S), selenium (Se), and tellurium (Te), R1 and R2 are independently selected from H, aliphatic groups, and aromatic groups bound to A through a carbon atom, or R1 and R2 together form an alicyclic ring containing A, and R3 is selected from H, aliphatic groups, aromatic groups, and alicyclic groups bound to D through a carbon atom.

The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and / or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

The invention provides a modified material for high-temperature-resistant precoated sand, the precoated sand and a preparation method of the precoated sand. The modified material is prepared from, by weight, 100-120 parts of a first mixture and 20-30 parts of a second mixture, and the mesh number of the modified material is not larger than 800 meshes; the mixture I comprises silica powder and a silane coupling agent, and the mass ratio of the silica powder to the silane coupling agent is 1000: (50-100); the mixture II comprises graphite and a coupling agent, the mass ratio of the graphite to the coupling agent is 1000: (100-200), and triethoxy in the silane coupling agent is combined with the silica powder to form silanol bonds which are bonded with inorganic matters; the amino group and the vinyl group are combined with the resin in a nitrogen bond and methine bonding manner; a benzene ring in phenylamino propyl trimethoxy silane and a graphite sheet layer realize physical adsorption through pi-pi stacking, and an amino group and an epoxy group react with phenolic resin to realize coupling, so that the effective combination of a high-temperature-resistant modified material and the resin is improved, the high-temperature resistance of a product is improved, and sand burning and casting carburization are prevented.

The invention discloses a method for preparing a pyrrolopyridine derivative by utilizing a reaction of conjugated diene functionalized isonitrile and methylene isonitrile, and belongs to the technical field of organic synthesis. The method comprises the following steps: by taking conjugated diene functionalized isonitrile and methylene isonitrile as reaction substrates and silver carbonate as a catalyst, reacting in an organic solvent to obtain the 1H-pyrrolo [2, 3-c] pyridine derivative, the structural formula of the 1H-pyrrolo [2, 3-c] pyridine derivative is shown in the specification. The 1H-pyrrolo [2, 3-c] pyridine derivative can be prepared by reacting two types of isocyanide compounds at normal temperature and normal pressure without isolating water or oxygen; the method has the advantages of mild reaction conditions, simple operation, simple and easily available raw materials and reagents and strong practicability, and is suitable for synthesizing various 1H-pyrrolo [2, 3-c] pyridine derivatives.

The application discloses a method for preparing pyrrolopyridine derivatives by reacting conjugated diene functionalized isonitrile and methine isonitrile, and belongs to the technical field of organic synthesis. The conjugated diene functionalized isonitrile and the methine isonitrile are used as reaction substrates, silver carbonate is used as a catalyst, and the reaction is carried out in an organic solvent to obtain 1H-pyrrolo[2,3-c]pyridine derivatives; the structural formula of the 1H-pyrrolo[2,3-c]pyridine derivatives is shown in the description. The application uses two types of isonitrile compounds, and the 1H-pyrrolo[2,3-c]pyridine derivatives can be prepared at normal temperature and pressure without isolating water or oxygen. The reaction condition is mild, the operation is simple, the raw materials and reagents are simple and easy to obtain, the practicability is high, and the method is suitable for synthesizing various 1H-pyrrolo[2,3-c]pyridine derivatives.

The present invention discloses a method for preparing a fluorine-containing polymer and a composition thereof, the method comprising the step of aqueous emulsion polymerization of one or more fluorinated monomers, the aqueous emulsion polymerization being performed in the presence of at least one surfactant comprising a monophosphate ester, the monophosphate ester contains an aromatic phenol group of an alkyl chain substituent; the monophosphate does not contain methyl, methylene and methine which are directly connected with an aromatic ring group; the surfactant does not contain methine; the methylene content of the surfactant is lower than 20% in terms of carbon atom number. According to the preparation method of the fluorine-containing polymer, a PFAS substance is not used as a surfactant, so that the preparation method is environment-friendly.

Provided is a surface protective film which comprises an adhesive layer, and which can exhibit both excellent anchoring force and suppression of the occurrence of spunlaces during cutting. A surface protective film according to an embodiment of the present invention comprises an adhesive layer comprising a urethane-based adhesive comprising a urethane polymer, the urethane-based adhesive being formed from a urethane-based adhesive composition, the urethane-based adhesive composition contains a base polymer (A) and a silicone-based compound (B), the base polymer (A) being a urethane prepolymer obtained by reacting a polyfunctional isocyanate compound with a polyol including a polyester polyol (a1) and a polyether polyol (a2), the polyether polyol (a2) contains a polyol (a3) containing three or more groups selected from the group consisting of methylene groups and methine groups.

Provided is a surface protective film including an adhesive agent layer and capable of achieving both excellent anchoring force and suppression of the formation of sizing scums when the film is cut.　A surface protective film according to an embodiment of the present invention includes an adhesive agent layer comprising a urethane-based adhesive agent, wherein the urethane-based adhesive agent comprises a urethane polymer, the urethane-based adhesive agent is made of a urethane-based adhesive agent composition, the urethane-based adhesive agent composition comprises a base polymer (A) and a silicone-based compound (B), the base polymer (A) is a urethane prepolymer produced by reacting a polyol with a polyfunctional isocyanate compound, the polyol includes a polyester polyol (a1) and a polyether polyol (a2), and the polyether polyol (a2) includes a polyol (a3) containing three or more groups of at least one type, the groups being selected from the group consisting of a methylene group and a methine group.

The present invention provides a surface protection film comprising an adhesive layer, capable of exhibiting sufficient strong adhesion to a substrate before UV irradiation, excellent peelability that allows for smooth peeling from the substrate after UV irradiation, and excellent storage stability. The surface protection film according to an embodiment of the present invention is a surface protection film comprising an adhesive layer, wherein the adhesive constituting the adhesive layer is formed as an adhesive composition, and the adhesive composition comprises a urethane prepolymer (A), a crosslinking agent (B), a photopolymerization initiator (C), and an antioxidant (D), wherein the urethane prepolymer (A) comprises an alkylene oxide backbone comprising two of at least one group selected from the group consisting of methylene groups and methine groups, and an alkylene oxide backbone comprising three or more of at least one group selected from the group consisting of methylene groups and methine groups.

An amine compound according to the present invention has a benzazole ring structure represented by general formula (a). The amine compound exhibits excellent stability and durability in thin films, and can provide, through optimization of the molecular design, a material in which the refractive index of visible light is high and the extinction coefficient of light near ultraviolet light is high. By using the compound in a material constituting a capping layer, an organic EL element that has excellent luminous efficiency can be obtained. R1-R4 each represent H, an aryl group, or a heteroaryl group, where at least one of these represents an aryl group or a heteroaryl group. L1-L3 each represent a divalent group such as a phenylene group, X1-X3 each represent O or S, and Y1 and Y2 each represent N or a methine group.

The present disclosure relates to a cyanine compound represented by formula (1). [In formula (1), R11 and R21 represent an alkyl group having 3 or more carbon atoms, R15 and R14 are linked to form an aromatic ring, or R15 and R14 are linked to form an aromatic ring with X1, which is a carbon atom, when R15 and R14 are linked to form an aromatic ring, X1 represents CR16R17, and when R15 and X1 are linked to form an aromatic ring, R14 represents an alkyl group having 4 or more carbon atoms or an alkoxy group having 3 or more carbon atoms; r25 and R24 are linked to form an aromatic ring, or are linked to X2 which is a carbon atom to form an aromatic ring, when R25 and R24 are linked to form an aromatic ring, X2 represents CR26R27, when R25 and X2 are linked to form an aromatic ring, R24 represents an alkyl group having 4 or more carbon atoms or an alkoxy group having 3 or more carbon atoms, and L represents a methine chain] # imgabs0 #

The present invention is a material for laser welding, which contains a resin and a cyanine compound represented by formula (1), and which is characterized in that the cyanine compound has an average transmittance of 81% or more in the wavelength range of 380 nm to 780 nm when the transmittance of the maximum absorption wavelength is 10% in the wavelength range of 300 nm to 1300 nm. [In formula (1), L represents a methine chain having 3-9 carbon atoms, methine groups contained in the methine chain each independently have a substituent, the substituents can be connected to each other, A + and A represent groups bonded to methine chain L, and X-represents a monovalent anion having a conjugated acid pKa of-8.0 or less]