15 results about "Methine group" patented technology

Provided is a compound represented by general formula (1). In formula (1), X1 and X2 are each independently selected from the group consisting of a methine group and a nitrogen atom, n is an integer of 0-3, R1 and R2 are each independently a hydrogen atom, a halogen atom, or a monovalent organic group, R1 and / or R2 is a monovalent organic group having a Hammett substituent constant σp of 0.50 or greater, and the adjacent R1 and R2 moieties may be a part of a fused ring, the fused ring optionally including one or more atoms other than carbon.

[Problem] To provide a substance having an activity of antagonizing the binding of histamine to histamine-H3 receptor, or having an activity of inhibiting the homeostatic activity of histamine-H3 receptor. [Means for Solution] A compound of the following formula (I) is provided: [wherein X, Y, Z and W each independently represent a methine group optionally having 1 or 2 substituents, or a nitrogen atom (provided that a case where all of X, Y, Z and W are an optionallysubstituted methine group); A, B and D represent C(0)-, etc.; Q represents a methine group or a nitrogen atom; R represents an optionallysubstituted group of the following formula (II-1): (wherein R7 and R8 each independently represent a lower alkyl group, etc.)].

The invention discloses a thiophenol-heptamethine cyanine dye derivative as well as self-assembled nanoparticles, a preparation method and application thereof. The derivative is a thiophenol-heptamethine cyanine dye monomer derivative or a 1, 3, 5-benzene trithiophenol-heptamethine cyanine dye triad derivative; the thiophenol or the 1, 3, 5-benzene trithiophenol is connected with a meso-carbon atom of the heptamethine cyanine dye through a sulfur atom, and the heptamethine cyanine dye is formed by connecting two nitrogen-containing heterocyclic ring units through a conjugated methine chain; the nanoparticles are obtained by dropwise adding a derivative solution into water and then removing an organic solvent. The synthesis method of the thiophenol-cyanine dye derivative is simple and easy to implement, stable nanoparticles can be formed, the tumor targeting property can be improved, the aggregation effect far better than that driven by traditional weak interaction is achieved, synchronous optimization of high tumor accumulation and extremely high heat production efficiency is successfully achieved through self-assembly of nanoparticles, and the thiophenol-cyanine dye derivative has good application prospects. An innovative strategy is provided for the development of a high-performance tumor photo-thermal reagent.

A compound represented by formula (I) (wherein each X is independently a methine group or a nitrogen atom, n is an integer of 0-3, each R1-R5 is independently a hydrogen atom, a halogen atom, a cyano group, a linear, branched or cyclic alkyl group, or the like, each R6-R7 is independently a hydrogen atom, a halogen atom other than a fluorine atom, a cyano group, a linear, branched or cyclic alkyl group, or the like, and n is an integer of 0-3. And one or more of R1-R5 and one or more of R6-R7 are a halogen atom or a monovalent organic group having a Hammett substituent constant [sigma] p of 0.10 or more).

This invention discloses a method for preparing co-assembled nanoparticles of thiophenol-heptamethine dye monomer and its triplet derivative, as well as their applications. The co-assembled nanoparticles comprise thiophenol-heptamethine dye monomer and a triplet derivative. The derivative is formed by linking the sulfur atom of thiophenol to the middle carbon atom of heptamethine dye, and the heptamethine dye is formed by two nitrogen-containing heterocyclic units linked by a conjugated methylene chain. The method involves mixing solutions of the two derivatives and adding them dropwise to water, followed by removal of the organic solvent to obtain co-assembled nanoparticles with uniform particle size. This invention significantly enhances the assembly stability of the nanoparticles while successfully retaining the excellent photothermal conversion efficiency of the triplet derivative, overcoming the technical bottleneck of the difficulty in stabilizing high-heat-generating molecules into particles. It achieves synergistic optimization of the assembly stability and photothermal efficiency of photothermal reagents, providing a novel design strategy and technical support for the development of high-performance tumor photothermal therapy drugs.

A surfactant and the use thereof, a preparation method for a fluoropolymer, and a fluoropolymer composition. The surfactant comprises a monophosphate, wherein the monophosphate contains an arylphenolic group having an alkyl chain substituent, and does not contain methyl, methylene or methine directly linked to an aromatic ring group. The surfactant does not contain methine. The methylene content of the surfactant is less than 20% in terms of the number of carbon atoms. The surface tension of a neutral aqueous solution containing 1 wt% of the surfactant is 26 mN / m to 31 mN / m.

The invention discloses a method for preparing metacycline hydrochloride with low impurity content by directly neutralizing a 11a-chloro-6-methylenetetracycline solution serving as a raw material, and belongs to the technical field of chemical engineering. The method comprises the following steps: adding a neutralizer into a 11a-chlorine-6-methine oxytetracycline solution for neutralization treatment, and filtering to obtain a 11a-chlorine-6-methine oxytetracycline neutralization solution; the method comprises the following steps: adding a 11a-chlorine-6-methyleneoxytetracycline neutralization solution and a regenerated palladium-carbon catalyst into an alcoholic solution, carrying out temperature-controlled hydrodechlorination reaction, filtering, adding sulfosalicylic acid into filtrate, and crystallizing to form salt, so as to obtain the methyleneoxytetracycline, and reacting methyleneoxytetracycline with hydrochloric acid, crystallizing, filtering, and drying to obtain the metacycline hydrochloride. According to the method, a 11a-chloro-6-methyleneoxytetracycline salifying process is not carried out, and the purity and quality of a metacycline hydrochloride product are improved while the production cost is reduced by simplifying a synthetic route, optimizing a process and reducing emission of three wastes (waste gas, waste water and industrial residues).

The application discloses a method for preparing pyrrolopyridine derivatives by reacting conjugated diene functionalized isonitrile and methine isonitrile, and belongs to the technical field of organic synthesis. The conjugated diene functionalized isonitrile and the methine isonitrile are used as reaction substrates, silver carbonate is used as a catalyst, and the reaction is carried out in an organic solvent to obtain 1H-pyrrolo[2,3-c]pyridine derivatives; the structural formula of the 1H-pyrrolo[2,3-c]pyridine derivatives is shown in the description. The application uses two types of isonitrile compounds, and the 1H-pyrrolo[2,3-c]pyridine derivatives can be prepared at normal temperature and pressure without isolating water or oxygen. The reaction condition is mild, the operation is simple, the raw materials and reagents are simple and easy to obtain, the practicability is high, and the method is suitable for synthesizing various 1H-pyrrolo[2,3-c]pyridine derivatives.

The present invention discloses a method for preparing a fluorine-containing polymer and a composition thereof, the method comprising the step of aqueous emulsion polymerization of one or more fluorinated monomers, the aqueous emulsion polymerization being performed in the presence of at least one surfactant comprising a monophosphate ester, the monophosphate ester contains an aromatic phenol group of an alkyl chain substituent; the monophosphate does not contain methyl, methylene and methine which are directly connected with an aromatic ring group; the surfactant does not contain methine; the methylene content of the surfactant is lower than 20% in terms of carbon atom number. According to the preparation method of the fluorine-containing polymer, a PFAS substance is not used as a surfactant, so that the preparation method is environment-friendly.

Provided is a surface protective film which comprises an adhesive layer, and which can exhibit both excellent anchoring force and suppression of the occurrence of spunlaces during cutting. A surface protective film according to an embodiment of the present invention comprises an adhesive layer comprising a urethane-based adhesive comprising a urethane polymer, the urethane-based adhesive being formed from a urethane-based adhesive composition, the urethane-based adhesive composition contains a base polymer (A) and a silicone-based compound (B), the base polymer (A) being a urethane prepolymer obtained by reacting a polyfunctional isocyanate compound with a polyol including a polyester polyol (a1) and a polyether polyol (a2), the polyether polyol (a2) contains a polyol (a3) containing three or more groups selected from the group consisting of methylene groups and methine groups.

An amine compound according to the present invention has a benzazole ring structure represented by general formula (a). The amine compound exhibits excellent stability and durability in thin films, and can provide, through optimization of the molecular design, a material in which the refractive index of visible light is high and the extinction coefficient of light near ultraviolet light is high. By using the compound in a material constituting a capping layer, an organic EL element that has excellent luminous efficiency can be obtained. R1-R4 each represent H, an aryl group, or a heteroaryl group, where at least one of these represents an aryl group or a heteroaryl group. L1-L3 each represent a divalent group such as a phenylene group, X1-X3 each represent O or S, and Y1 and Y2 each represent N or a methine group.

The present invention is a material for laser welding, which contains a resin and a cyanine compound represented by formula (1), and which is characterized in that the cyanine compound has an average transmittance of 81% or more in the wavelength range of 380 nm to 780 nm when the transmittance of the maximum absorption wavelength is 10% in the wavelength range of 300 nm to 1300 nm. [In formula (1), L represents a methine chain having 3-9 carbon atoms, methine groups contained in the methine chain each independently have a substituent, the substituents can be connected to each other, A + and A represent groups bonded to methine chain L, and X-represents a monovalent anion having a conjugated acid pKa of-8.0 or less]

The invention discloses a low-tension surfactant, the low-tension surfactant comprises monophosphate, and the monophosphate contains an aromatic phenol group of an alkyl chain substituent; the monophosphate does not contain methyl, methylene and methine which are directly connected with an aromatic ring group; the low-tension surface active agent does not contain methine; the methylene content of the low-tension surfactant is lower than 20% in terms of carbon atom number; the surface tension of the neutral aqueous solution with the content of the low-tension surfactant being 1wt% is 26-31mN / m. The low-tension surfactant disclosed by the invention is wide in application, and especially can be used as an environment-friendly substitute of a PFAS substance.

The power cable of the present application has: a conductor; and an insulation layer provided so as to cover the outer periphery of the conductor and composed of a resin composition containing polyethylene, the insulation layer containing crosslinked polyethylene in the polyethylene that is insoluble in xylene at 120°C and un-crosslinked polyethylene in the polyethylene that is soluble out to xylene at 120°C, the content of methine groups in the un-crosslinked polyethylene being 0.5 or more and 3.0 or less per 100 carbon atoms in the un-crosslinked polyethylene.

The invention relates to the technical field of lithium batteries, in particular to an electrolyte additive, an electrolyte and a high-nickel ternary lithium battery. The electrolyte additive comprises fluorinated linear carbonate and fluorinated cyclic carbonate, perfluoroalkyl R1 in the fluorinated linear carbonate is connected with an oxygen atom through methylene, and perfluoroalkyl R2 in the fluorinated cyclic carbonate is connected with the oxygen atom through methylene. The fluorinated linear carbonate and the fluorinated cyclic carbonate with specific structures are simultaneously used as additives in a small amount in the electrolyte, the protection of the fluorinated cyclic carbonate on the negative electrode is greater than the protection of the positive electrode, and the protection of the fluorinated linear carbonate on the positive electrode is greater than the protection of the negative electrode. Effective SEI is formed synergistically, the circulation and storage performance of the high-nickel ternary lithium battery at a high temperature is remarkably improved, and the gas production rate is reduced.