168 results about "Isocyanide" patented technology

The invention discloses a preparation method of a thidiazuron preparation, and relates to the technical field of thidiazuron preparation. The preparation method of the thidiazuron preparation comprises the following steps: adding 5-amino-1, 2, 3-thiadiazole, ethylene glycol dimethyl ether and triethylamine into a four-neck flask, heating and uniformly stirring, dropwise adding phenyl isocyanate into the mixed solution obtained in the step 1, heating to carry out catalytic synthesis reaction, cooling to room temperature, and carrying out suction filtration to obtain yellow solid thidiazuron. And further treating to obtain the thidiazuron preparation. Sodium nitrite is selected as a solvent in the preparation process of 5-amino-1, 2, 3-thiadiazole, and the amount of substance of another initial material aminoacetonitrile hydrochloride is controlled in the preparation reaction, so that the yield of thidiazuron is ensured to be optimal, the reaction temperature range and the dropwise adding amount are determined, the optimal reaction conditions are finally perfected, and the yield of 5-amino-1, 2, 3-thiadiazole is improved. A preparation mode which is simpler to operate, higher in yield and suitable for industrial production is provided for preparation of the thidiazuron preparation.

The invention discloses an electro-synthesis method of alpha-aminomethyl tetrazole, which comprises the following steps: by taking a platinum sheet as a cathode, a carbon rod as an anode and tetrabutylammonium tetrafluoroborate as an electrolyte under the catalysis of constant current, coupling tertiary amine, isonitrile and azido trimethylsilane by a one-pot method to prepare an alpha-aminomethyl tetrazole derivative, and carrying out post-treatment on the obtained reaction mixed solution, and carrying out column chromatography separation to obtain a pure alpha-aminomethyl tetrazole product. The alpha-aminomethyl tetrazole can be obtained only through one-step reaction, the operation steps are few, a large number of oxidizing agents and additives are not used, the post-treatment process is simple, and the product is easy to separate.

The invention provides a positive pole piece, an electrochemical device and an electronic device, the positive pole piece comprises a positive current collector, a positive active material layer and a coating, the coating is located on the surface and / or inside the positive active material layer, and the coating comprises an organic compound, the organic compound comprises at least one functional group of a cyano group, an isonitrile group, an azinyl group and an isocyanate group, the thickness of the coating is 0.3-3 [mu] m, and the ratio of the thickness of the coating to the thickness of the positive electrode active material layer is 1: (5-50). The positive pole piece provided by the invention can improve the thermal safety, the high-temperature cycle performance, the high-temperature storage expansion rate and the mechanical safety of the electrochemical device.

The invention belongs to the technical field of biological medicines, and discloses lipid nanoparticles for muscle in-situ delivery as well as a preparation method and application of the lipid nanoparticles. According to the invention, four components Ugi of aldehyde, isonitrile, amine and carboxylic acid are subjected to a reaction to synthesize the ionizable cationic lipid. The ionizable cation lipid formed by introducing an ionizable cation head group into an isonitrile component has muscle in-situ nucleic acid delivery performance. The unsaturation degree of a lipid hydrophobic tail chain, the number of methylene spacers of an ionizable cation head group and LNP formula composition and process are further optimized, muscle in-situ selective mRNA delivery performance is enhanced, off-target liver expression is avoided, safety can be improved, and different application requirements of mRNA vaccines, nucleic acid drugs, gene editing and the like can be met.

The invention relates to a light-cured dental resin adhesive containing a silane coupling agent modified monomer as well as preparation and application of the light-cured dental resin adhesive. The dental resin adhesive comprises a resin matrix, an organic polymer and a photoinitiator, wherein the resin matrix consists of methacrylate resin grafted and modified by a silane coupling agent and unmodified methacrylate resin. According to the method, the isocyano group of the silane coupling agent is selected to react with the hydroxyl group on the resin monomer to generate the silane modified grafted resin monomer, and the method is simple, low in equipment requirement and suitable for large-scale production; the obtained dental resin adhesive can be internally covalently cross-linked to enhance the self mechanical property, can also be chemically bonded with a bonding substrate by utilizing a grafted silane coupling agent to improve the interface bonding strength, is especially suitable for being used as an enamel bonding material, and can remarkably improve the service life and the curative effect of a bonded restoration.

The invention discloses a synthesis method of an N-formamide derivative, and belongs to the technical field of chemical synthesis, the N-formamide derivative is obtained by a one-step method by taking an isonitrile compound as a substrate and a titanocene compound as a catalyst and carrying out hydrolysis reaction in an organic solvent at room temperature and normal pressure. According to the method, the titanocene compound is used as a catalyst, and the hydrolysis reaction is selectively terminated to the step of generating the formamide compound in the isonitrile compound hydrolysis process, so that the isonitrile compound is prevented from being further hydrolyzed to generate the amine compound. The method has the advantages of simple reaction process, cheap and easily available reaction system, wide substrate range, mild reaction conditions, high target product yield and no burden on the environment.

The invention relates to the technical field of electrolyte, in particular to a thioether cross-linked solid polymer electrolyte membrane as well as a preparation method and application thereof. The preparation method comprises the following steps: taking N, N-dimethylformamide, respectively adding 3, 6-dioxa-1, 8-octane dithiol and triglycidyl isocyanurate, and uniformly stirring to obtain a mixed solution; adding bis (trifluoromethylsulfonyl) imide lithium into the mixed solution, putting magnetons on a magnetic stirrer, and completely dissolving the magnetons to obtain a precursor solution; and pouring a proper amount of the precursor solution into a polytetrafluoroethylene mold, spreading, and carrying out cross-linking polymerization in a blast oven to form the film. The three-dimensional thioether cross-linked network structure has a large number of weakly coordinated thioether groups, dissociation of lithium salt can be promoted, a large number of free Li < + > is generated, the number of Li < + > is increased, meanwhile, the crystallinity of a polymer is remarkably reduced, the ionic conductivity is improved, the mechanical stability of a film can be improved, and the service life of a battery is effectively prolonged.

The invention discloses fireproof flame-retardant phenolic resin and a preparation method thereof, and relates to the technical field of high polymer materials. When the fireproof flame-retardant phenolic resin is prepared, firstly, alkali lignin is depolymerized in a lithium bromide solution, and depolymerized lignin is prepared; carrying out multi-component reaction on the depolymerized lignin, amino-terminated polydimethylsiloxane, isonitrile diethyl methylphosphate and glacial acetic acid to prepare modified lignin; the preparation method comprises the following steps: carrying out reaction modification on montmorillonite and diisocyanate to prepare isocyanate modified montmorillonite; the isocyanate modified montmorillonite and 3-aminopropyltriethoxysilane are subjected to a reaction, and modified montmorillonite is prepared; and polymerizing phenol with the modified lignin, paraformaldehyde and modified montmorillonite, and discharging to obtain the fireproof flame-retardant phenolic resin. The prepared fireproof flame-retardant phenolic resin has the advantages of flame retardance, good toughness, high strength and aging resistance.

The invention discloses a large-steric-hindrance nitrile compound and a preparation method and application thereof.The preparation method comprises the steps that indole carbonate and benzyl isocyanide serve as reaction raw materials, and the nitrile compound with a large-steric-hindrance quaternary carbon center is prepared through a one-pot method in the presence of a metal salt catalyst and a solvent; the invention provides a large-steric-hindrance nitrile compound which has the advantages of higher step economy, atom economy, convenience in post-treatment, rapidness and high efficiency. The high-steric-hindrance nitrile compound is constructed in one step by using simple raw materials, has the advantages of cheap and easily available raw materials, simple and mild conditions, high atom economy, excellent yield and wide substrate range, provides a green synthesis method for efficient construction of a high-steric-hindrance nitrile compound skeleton, and is convenient for preparation of the high-steric-hindrance nitrile compound and application of the high-steric-hindrance nitrile compound in the field of drug preparation.

The invention relates to the technical field of radiopharmaceutical chemistry and clinical nuclear medicine, in particular to preparation and application of isonitrile mannose cuprous complex salt derivatives. The structure of the isonitrile mannose cuprous complex salt derivative is shown in (I), the isonitrile mannose cuprous complex salt derivative is good in stability, a marking method is simple when a freeze-drying medicine box prepared from the isonitrile mannose cuprous complex salt derivative is used for preparing < 99m > Tc tumor marking radiopharmaceuticals, the marking rate of a final product is larger than 90%, the tumor affinity performance is good, and clinical application and popularization are convenient. # imgabs0 #

The invention discloses a supporting layer suitable for a composite current collector, a corresponding composite current collector and a battery. Wherein the supporting layer is formed by curing insulating adhesive liquid; the insulating adhesive liquid comprises a component A and a component B which are mixed, wherein the component A is at least one of polyurethane resin, acrylic resin, epoxy resin, polyester resin, polyimide, an organosilicon polymer and a modified compound thereof; the liquid B is at least one of amino resin, isocyanate, an aziridine cross-linking agent, carbodiimide, a silane coupling agent and an organic silicon tackifier; wherein the ratio of the component A to the component B is (90-99): (1-5). Compared with an existing supporting layer and an existing composite current collector, the viscous insulating layer structure can replace common PET, PP, PI and other types of base film middle supporting layer structures, the adhesive strength of the metal layer and the supporting layer is improved, and meanwhile additional hierarchical structures are avoided. And the production process is simplified, so that mass production is realized.

The invention belongs to the technical field of organic synthesis, and discloses a synthesis method of polysubstituted 1, 3-conjugated diene. The synthesis method of the polysubstituted 1, 3-conjugated diene comprises the following steps: in a protective atmosphere, with an organic solvent as a reaction medium, carrying out a reaction on a carboxylic acid compound, isonitrile and propargyl ester under the action of a weakly alkaline salt, a catalyst and a ligand to obtain the polysubstituted 1, 3-conjugated diene. The structure of the polysubstituted 1, 3-conjugated diene is shown in the specification. The method is simple, the raw materials are cheap and easy to obtain, the polysubstituted 1, 3-conjugated diene compound with rich and diversified structures can be constructed in one step, the yield is high, the substrate applicability is wide, and the atom economy is high. # imgabs0 #

The invention relates to the technical field of medical biological materials, in particular to an in-situ temperature-sensitive gel drug-loaded preparation and a preparation method thereof, and the composition of the in-situ temperature-sensitive gel drug-loaded preparation comprises the following raw materials in percentage by mass: 10-50% of poloxamer 407; the composition further comprises any one of the following raw materials in percentage by mass: 1%-10% of poloxamer 188; or 1%-20% of hydroxypropyl methyl cellulose; or 0.1%-5% of polydopamine; or 0.03%-0.4% of a helical polyisocyanide polypeptide; or 0.1%-5% of polydopamine and 0.03%-0.4% of spiral polyisocyanide polypeptide. The in-situ temperature-sensitive gel drug-loaded preparation prepared by the invention has excellent temperature sensitivity, can keep flowing at low temperature, is convenient to apply, can be rapidly cured into gel at body temperature, realizes long-acting structural support and precise drug delivery, and remarkably improves the wound repair effect.

The invention relates to polyamide synthesized by carbon dioxide and a preparation method thereof, and belongs to the technical field of polymer synthesis. The technical problems of long reaction time, low yield, poor product performance and the like in the existing technology for converting the carbon dioxide into the polymer by utilizing the Ugi multi-component reaction are solved. The preparation method comprises the following steps: in a halogenated hydrocarbon solvent, pre-polymerizing primary diamine and aryl dialdehyde, adding alcohols, an organic base catalyst, CO2 and mono-functional group isonitrile, reacting to obtain a reactant, and purifying the reactant to obtain polyamide. The preparation method is mild in reaction condition, short in reaction time and high in yield, the use of di-isonitrile is avoided, the cost can be reduced, and the prepared polyamide has excellent solvent resistance, is only slowly dissolved in dichloromethane and trichloromethane and is insoluble in other solvents.

The invention discloses a method for synthesizing a quinazoline diketone compound, which comprises the following steps: firstly synthesizing a metallized porous organic polymer catalyst Pd (at) POL-TBZP, and successfully catalytically synthesizing the quinazoline diketone compound by taking the metallized porous organic polymer catalyst Pd (at) POL-TBZP as a basis and taking o-bromoaniline, isonitrile and carbon dioxide under normal pressure as raw materials. The method is low in cost and high in catalytic efficiency, the activity of the catalyst is still kept stable after the catalyst is recycled for 6 times, and good industrial application potential is shown.

Methods of selectively depositing a passivation layer on a metal surface of a semiconductor substrate are described. Exemplary methods may include exposing the semiconductor substrate having a metal surface and a non-metal surface to a first precursor to form a first portion of the passivation layer on the metal surface, the first precursor including an isonitrile. The exemplary methods may further include exposing the semiconductor substrate comprising a metal surface and a non-metal surface to a second precursor to form the passivation layer on the metal surface. The second precursor may include an amine, an alcohol, or a thiol.

The application discloses a kind of tetrahydrocarbazole derivatives and its photocatalytic synthesis method, belong to organic synthesis technical field, 2-arylene phenyl isonitrile compound, cyclopropyl aniline compound and photocatalyst are added to solvent, after photocatalytic reaction, again separation and purification, obtain tetrahydrocarbazole derivative.This method is more simple compared with the method for using no tetrahydrocarbazole synthesis N-substituted tetrahydrocarbazole derivative, and no additional various additives in reaction, the atomic utilization rate of cyclopropyl aniline compound and 2-arylene phenyl isonitrile compound reaches 100%, reflects atomic economy, raw material is cheap and easy to obtain, reaction cost is low, and environment friendly;It is easy to operate, and target product can be efficiently obtained.The photocatalytic synthesis method of the tetrahydrocarbazole derivative is good in universality of raw material, and raw material is widely sourced, under optimized reaction condition, target product is easy to separate, and has potential application value in material and pharmaceutical field.

The invention discloses a method for preparing fused ring arylamine from isonitrile and cyclopropene. The reaction formula is as follows: # imgabs0 #.

The present invention relates to the fields of pharmaceutical engineering and medical technology, and particularly to a compound with anti-lung cancer activity, a preparation method thereof, and an application thereof. In the present invention, an ionic liquid is used as a solvent, and Z-2-chloromethyl-3-phenylacrylic acid, 3-p-chlorophenylacrolein, benzylamine, and cyclohexyl isocyanide are used as raw materials, and a compound with anti-lung cancer activity is obtained through a microwave-assisted one-pot reaction. The method of the present invention has the characteristics of simplicity, low cost, and greenness, and the prepared compound with anti-lung cancer activity has a good effect of inhibiting the proliferation and inducing apoptosis of lung cancer cells.

The application discloses a kind of all-substituted pyrrole compounds, the raw material alkyne compound of the application has structural diversity with isonitrile compound, can be used to synthesize different types and structures of all-substituted pyrrole compounds;Reaction raw material diphenylacetylene and its same type substrate compared with the raw material of the reaction reported by predecessors, have the advantages of simple and easy to obtain, stable nature;All-substituted pyrrole compounds have good diversity and functional group tolerance, so it has wide application;Further modification is carried out to different substitution sites on the heterocyclic skeleton of all-substituted pyrrole compounds, and intermediates of chemical products and drug structures can be obtained;The target product of the application takes pyrrole as the key mother nucleus, while amide and other unsaturated groups are introduced on the ring, and the structure has potential pharmacological activity;Cheap transition metal nickel is used as catalyst;The yield of the application is good.

The invention relates to synthesis of a tridentate bis (oxazoline phenyl) amino palladium metal methyl compound and preparation of a catalytic system, and belongs to the technical field of catalysts. The catalyst is used for catalyzing the polymerization reaction of isonitrile polymerization. A high-molecular-weight polymer can be obtained in the reaction process. The tridentate bis (oxazoline phenyl) amino palladium metal methyl compound catalytic system is obtained through one-step reaction, the raw materials are easy to obtain and modify, the economic efficiency is high, the catalyst does not need complex synthesis steps, the environmental protection property is good, and the tridentate bis (oxazoline phenyl) amino palladium metal methyl compound catalytic system is suitable for industrial production. The work provides a new thought for a new catalyst system.

The invention relates to the field of biological medicine, and provides an ionizable lipid compound capable of activating an STING signal channel and application of the ionizable lipid compound. The invention specifically provides an ionizable lipid compound which has a natural adjuvant effect and can induce generation of I-type interferon gene expression by activating an STING pathway, so that APC activation and antigen presentation are promoted, and the immune response ability of a body is enhanced. And a method for synthesizing the ionizable lipid compound from a ketone compound, an amine compound and an isonitrile compound. The invention also provides an application of the ionizable lipid compound in preparation of lipid nanoparticles, the lipid nanoparticles formed by the ionizable lipid can deliver nucleic acid molecules into cells, the expression level of nucleic acid drugs in vivo can be significantly improved, and the immune response of the organism can be stimulated. Ionizable lipid compound having the structure shown: # imgabs0 #

This article relates to a method for preparing phenanthridine. The invention involves converting biphenyl isonitriles into polysubstituted phenanthridines and their derivatives under photocatalysis and blue light in an argon atmosphere, yielding molecules with stable structures and excellent chemical properties. The synthetic method utilizes inexpensive and readily available raw materials; the reaction requires only a photocatalyst, additives, and blue light, thus saving raw materials and reducing reaction costs. The entire reaction system is simple, the reaction conditions are mild, the required equipment is minimal, the experimental operation is straightforward, and the yield is moderate to high.

The embodiment of the invention provides an electrolyte, a battery monomer containing the electrolyte, a battery and an electric device. The electrolyte comprises a first additive, and the first additive comprises an isocyanate compound shown in the formula (I), r comprises a hydrogen atom, a halogen atom, a nitrogen-containing group, an oxygen-containing group, a sulfur-containing group, a phosphorus-containing group, an alkyl group, a naphthenic base, a phenyl group, an aryl group, a halogenated phenyl group and at least one of an alkyl group, a naphthenic base, a phenyl group, an aryl group and a halogenated phenyl group containing at least one isocyanic acid radical, and n is any natural number from 0 to 8; the lithium salt comprises lithium bis (fluorosulfonyl) imide, the weight content of the lithium bis (fluorosulfonyl) imide in the lithium salt is 30-85% based on the total weight of the lithium salt, and the cycle performance and the storage life of the battery containing the electrolyte are improved. # imgabs0 #

Methods and apparatuses for using molecules having a carbon-nitrogen triple bond as inhibitors on metal-containing surfaces to selectively deposit dielectric material on a dielectric surface on a substrate surface having a metal-containing surface and a dielectric surface are provided. A method for processing substrates comprises providing a substrate having a first material and a second material thereon to a process chamber, exposing the substrate to an isonitrile inhibitor to adsorb onto the first material to inhibit deposition on the first material, and depositing a dielectric film on the second material.

Described herein are steroid or steroid-like compounds including at least one isonitrile group and which inhibit the activity of a cytochrome P450 enzyme, as well as compositions including the compounds. Also included are methods of inhibiting activity of a cytochrome P450 in a subject having a steroid-responsive cancer, a Mycobacterium tuberculosis infection, a fungal infection, or a trypanosome infection, the method comprising administering to the subject the compound including at least one isonitrile group or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit the CYP activity in the subject.

Compounds of Formula I,are provided. In Formula I, M is Pd or Pt; each of X1 to X14 is C or N; one of Z1 and Z2 is C and the other is N; Y is selected from O, S, Se, N*R, CRR′, SiRR′, or GeRR′; K1 is a direct bond, O, or S; each R, R′, RA, RB, RC, and RD is independently hydrogen or a substituent; at least one of R, R′, RA, RB, RC, or RD is a substituent R*; and (i) R* comprises a 5-membered or 6-membered heterocyclic ring, or (ii) R* comprises Formula Ia:Formula Ia;wherein each of RY and RZ independently represents mono to the maximum allowable substitution, or no substitution;R1, R2, R3, R4, RY and RZ is independently hydrogen or a substituent selected from the group consisting of deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, germyl, boryl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carboxylic acid, ether, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, boryl, selenyl, and combinations thereof;wherein at least one of R1, R2, R3, and R4 is not hydrogen. Formulations, OLEDs, and consumer products including the compound are also provided.

The invention relates to the technical field of agricultural plant growth regulators, and discloses a phosphate compound containing an amide group as well as a preparation method and application thereof. O-aminopyridine, different substituted benzaldehyde and isocyanide are used as initial raw materials, and ring closing and ring opening are performed to obtain the phosphate compound containing the amide group. And finally, reacting with dialkyl phosphite to obtain the phosphate ester compound containing the amide group. The phosphate ester compound containing the amide group is high in activity, high in stability, simple in synthesis route and low in cost, can serve as an ABA analogue to be combined with abscisic acid receptor (PYL3) protein, can promote plant stomata closing and regulate crop root growth, and can be used as an abscisic acid receptor (PYL3) protein. Further, the drought stress regulation capability of the plants is improved.

Methods of selectively depositing a passivation layer on a metal surface of a semiconductor substrate are described. Exemplary methods may include exposing the semiconductor substrate having a metal surface and a non-metal surface to a first precursor to form a first portion of the passivation layer on the metal surface, the first precursor including an isonitrile. The exemplary methods may further include exposing the semiconductor substrate comprising a metal surface and a non-metal surface to a second precursor to form the passivation layer on the metal surface. The second precursor may include an amine, an alcohol, or a thiol.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of long-chain fatty amine, acylamino long-chain fatty acid, long-chain omega-amino fatty acid and long-chain nylon. The preparation method of the long-chain fatty amine comprises the following steps: mixing sodium hypohalide and an organic solvent, and carrying out Hofmann rearrangement reaction to obtain a transition-state reaction solution; and then adjusting the transition state reaction liquid to be alkaline, and carrying out hydrolysis reaction to obtain the long-chain fatty amine. Wherein the structural formula of the long-chain fatty amine is shown in the specification, and n represents an even number of 8-14; the transition state reaction liquid comprises an isocyanate intermediate; and the organic solvent is mutually soluble with water. According to the invention, long-chain fatty amine is prepared from renewable long-chain fatty acid, and precursor substances of long-chain nylon such as nylon 11 and the like are prepared by adopting a chemical and microbial coupling method.