47 results about "Isocyanide" patented technology

The invention belongs to the technical field of biological medicines, and discloses lipid nanoparticles for muscle in-situ delivery as well as a preparation method and application of the lipid nanoparticles. According to the invention, four components Ugi of aldehyde, isonitrile, amine and carboxylic acid are subjected to a reaction to synthesize the ionizable cationic lipid. The ionizable cation lipid formed by introducing an ionizable cation head group into an isonitrile component has muscle in-situ nucleic acid delivery performance. The unsaturation degree of a lipid hydrophobic tail chain, the number of methylene spacers of an ionizable cation head group and LNP formula composition and process are further optimized, muscle in-situ selective mRNA delivery performance is enhanced, off-target liver expression is avoided, safety can be improved, and different application requirements of mRNA vaccines, nucleic acid drugs, gene editing and the like can be met.

The invention relates to the technical field of electrolyte, in particular to a thioether cross-linked solid polymer electrolyte membrane as well as a preparation method and application thereof. The preparation method comprises the following steps: taking N, N-dimethylformamide, respectively adding 3, 6-dioxa-1, 8-octane dithiol and triglycidyl isocyanurate, and uniformly stirring to obtain a mixed solution; adding bis (trifluoromethylsulfonyl) imide lithium into the mixed solution, putting magnetons on a magnetic stirrer, and completely dissolving the magnetons to obtain a precursor solution; and pouring a proper amount of the precursor solution into a polytetrafluoroethylene mold, spreading, and carrying out cross-linking polymerization in a blast oven to form the film. The three-dimensional thioether cross-linked network structure has a large number of weakly coordinated thioether groups, dissociation of lithium salt can be promoted, a large number of free Li < + > is generated, the number of Li < + > is increased, meanwhile, the crystallinity of a polymer is remarkably reduced, the ionic conductivity is improved, the mechanical stability of a film can be improved, and the service life of a battery is effectively prolonged.

This article relates to a method for preparing phenanthridine. The invention involves converting biphenyl isonitriles into polysubstituted phenanthridines and their derivatives under photocatalysis and blue light in an argon atmosphere, yielding molecules with stable structures and excellent chemical properties. The synthetic method utilizes inexpensive and readily available raw materials; the reaction requires only a photocatalyst, additives, and blue light, thus saving raw materials and reducing reaction costs. The entire reaction system is simple, the reaction conditions are mild, the required equipment is minimal, the experimental operation is straightforward, and the yield is moderate to high.

Described herein are steroid or steroid-like compounds including at least one isonitrile group and which inhibit the activity of a cytochrome P450 enzyme, as well as compositions including the compounds. Also included are methods of inhibiting activity of a cytochrome P450 in a subject having a steroid-responsive cancer, a Mycobacterium tuberculosis infection, a fungal infection, or a trypanosome infection, the method comprising administering to the subject the compound including at least one isonitrile group or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit the CYP activity in the subject.

The invention relates to the technical field of agricultural plant growth regulators, and discloses a phosphate compound containing an amide group as well as a preparation method and application thereof. O-aminopyridine, different substituted benzaldehyde and isocyanide are used as initial raw materials, and ring closing and ring opening are performed to obtain the phosphate compound containing the amide group. And finally, reacting with dialkyl phosphite to obtain the phosphate ester compound containing the amide group. The phosphate ester compound containing the amide group is high in activity, high in stability, simple in synthesis route and low in cost, can serve as an ABA analogue to be combined with abscisic acid receptor (PYL3) protein, can promote plant stomata closing and regulate crop root growth, and can be used as an abscisic acid receptor (PYL3) protein. Further, the drought stress regulation capability of the plants is improved.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of long-chain fatty amine, acylamino long-chain fatty acid, long-chain omega-amino fatty acid and long-chain nylon. The preparation method of the long-chain fatty amine comprises the following steps: mixing sodium hypohalide and an organic solvent, and carrying out Hofmann rearrangement reaction to obtain a transition-state reaction solution; and then adjusting the transition state reaction liquid to be alkaline, and carrying out hydrolysis reaction to obtain the long-chain fatty amine. Wherein the structural formula of the long-chain fatty amine is shown in the specification, and n represents an even number of 8-14; the transition state reaction liquid comprises an isocyanate intermediate; and the organic solvent is mutually soluble with water. According to the invention, long-chain fatty amine is prepared from renewable long-chain fatty acid, and precursor substances of long-chain nylon such as nylon 11 and the like are prepared by adopting a chemical and microbial coupling method.

The invention discloses a method for catalytic synthesis of sulfoximine guanidine compounds by cobalt dichloride, which realizes efficient preparation of the sulfoximine guanidine compounds by taking cobalt dichloride as a catalyst and through free radical coupling reaction of sulfoximine compounds, isonitrile compounds and sulfonyl azide compounds. The method can effectively protect high-valence thioguanidyl, has the advantages of mild reaction conditions, high synthesis efficiency and strong substrate universality, and has extremely high practical application value.

The invention relates to the technical field of lithium ion solid-state batteries, in particular to a lithium ion solid-state battery and a preparation method thereof. The lithium ion solid-state battery comprises a positive pole piece, a solid-state polymer electrolyte membrane and a lithium metal negative pole piece which are assembled together, the preparation method of the polymer electrolyte membrane comprises the following steps: respectively adding 3, 6-dioxa-1, 8-octane dithiol and triglycidyl isocyanurate into a solvent, and stirring to obtain a mixed solution; adding bis (trifluoromethylsulfonyl) imide lithium into the mixed solution, and dissolving to obtain a precursor solution; and carrying out cross-linking polymerization on the precursor solution to form the film. The lithium ion solid-state battery provided by the invention shows excellent capacity, excellent cycling stability and reversibility.

The invention belongs to the technical field of organic synthesis, and discloses a method for synthesizing gamma-lactam derivatives through cobalt catalytic cyclization. The method comprises the following steps: in a protective atmosphere, taking an organic solvent as a reaction medium, and reacting a propyne compound with an isonitrile compound and a carboxylic acid compound under the action of a catalyst, a ligand and alkali to obtain the unsaturated gamma-lactam derivative. The catalyst is a cobalt catalyst, and the ligand is a nitrogen or phosphine compound. The method disclosed by the invention is simple, low in cost, efficient in reaction, few in byproducts, easy to separate and purify and high in yield.

This invention discloses a α The electrosynthesis method of α-aminomethyltetrazole includes: using a platinum sheet as the cathode and a carbon rod as the anode, and employing ammonium tetrabutyltetrafluoroborate as the electrolyte under constant current catalysis, a one-pot coupling of a tertiary amine, an isonitrile, and azide trimethylsilane to prepare the α-aminomethyltetrazole. α The step involving the aminomethyltetrazole derivative, followed by post-treatment and column chromatography separation of the resulting reaction mixture, yields... α - Pure aminomethyltetrazole. This invention yields it through a single reaction step. α -Aminomethyltetrazole has fewer operating steps, avoids the use of large amounts of oxidants and additives, simplifies post-processing, and makes the product easy to separate.

The present invention discloses a method for preparing a series of vonoprazan intermediates using an isonitrile and a Michael acceptor. In the method of the present invention, α-(p-toluenesulfonyl)-2-fluorobenzylisonitrile is used as the starting material, which attacks a series of Michael acceptors under basic conditions and undergoes cyclization to form a series of 3-substituted 5-(2-fluorophenyl)-1H-pyrroles. These 3-substituted pyrrole intermediates can be further chemically transformed to prepare vonoprazan. Compared with the prior art, the technical means of the present invention are characterized by a short synthetic route, high overall yield, simple post-treatment, and low cost.

This invention discloses a method for synthesizing 6-arylphenanthrene diphenyl compounds. The method involves a dehydrazine radical tandem addition-cyclization reaction of 2-isocyanuric biphenyl and arylhydrazine under air atmosphere and blue visible light irradiation, catalyzed by a molybdenum sulfide / N-hydroxyphthalimide synergistic catalytic system, to generate 6-arylphenanthrene diphenyl compounds. This method has the advantages of readily available raw materials, simple operation, mild reaction conditions, high reaction selectivity and yield, and excellent substrate functional group compatibility.

The application discloses a preparation method and application of a photocatalytic synthesis of nitrogen heteroaromatic compound, and the nitrogen heteroaromatic compound is obtained by mixing isonitrile compound, alkyl boronic acid reagent, photosensitizer, alkali reagent and solvent and then performing a reaction under irradiation of visible light. The synthesis method has the advantages of easy availability of raw materials, simple operation, mild reaction and wide applicability of substrates, and the obtained indole / pyrrolo[1,2-a]quinoxaline compound has fluorescence performance.

The application discloses an anthracene compound and application thereof in an organic electroluminescent device, and has a chemical structure as shown in the formula (1), R1-R8 are selected from hydrogen, deuterium, tritium, fluorine, chlorine, bromine, a cyano group, an isonitrile group, a trifluoromethyl group, a nitro group, a substituted or unsubstituted alkyl group, a cycloalkyl group, an alkoxy group, an alkylthio group, an aryl group, a heteroaryl group, a keto group, an alkoxycarbonyl group or an aryloxycarbonyl group and the like; L1 and L2 are selected from a substituted or unsubstituted C6-C30 arylene group or a C2-C30 heteroarylene group; A1 and A2 are selected from a substituted or unsubstituted C6-C40 aryl group or a C2-C40 heteroaryl group or a group as shown in the formula (2). The anthracene compound of the application is used in an OLED device as a light-emitting host material and the like, has a simple synthesis process and can effectively improve the light-emitting efficiency and service life of the device.

The application belongs to the field of fluorescent probes, and relates to a lysosome-targeting fluorescent probe and a preparation method and application thereof. An intermediate is prepared by mixing an aldehyde compound, 5-amino fluorescein and 7-bromoheptanoic acid, and then performing a reaction; the intermediate is mixed with morpholine, and then a reaction is performed, so that the lysosome-targeting fluorescent probe is obtained. The application belongs to the construction of a complex molecular system with flexible and modular Ugi four-component reaction, adopts a one-pot method, and is synthesized by a framework template conjugation method, and the yield of the product is between 60% and 80%. The fluorescent probe prepared in the application can target lysosomes, and can be used as a lysosome-targeting imaging agent for living cancer cells. The fluorescent probe containing ferrocene prepared in the application can target lysosomes, and can be used as a lysosome-targeting imaging agent and a therapeutic agent for living cancer cells. The fluorescent probe containing ferrocene prepared in the application can effectively inhibit the growth of Hela and other cancer cells.

A metal iridium complexes, devices containing the same, and formulations including the same described. The complexes can have the formula Ir(L1)n(L2)3−n, whereinthe first ligand L1 has Formula I,the second ligand L2 has Formula II,L1 is different from L2; R1 is a partially or fully deuterated group consisting of alkyl and cycloalkyl; R2 represents mono, di, tri substitutions or no substitution; R3, R4, and R5 each represent mono, di, tri, tetra substitutions or no substitution; R2 and R3 are each independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, and combinations thereof; R4 and R5 are each independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; and n is 1 or 2. Homoleptic, tris-iridium complex including deuterated alkyl groups are also described.

A process for the preparation of fused ring arylamines from isonitriles and cyclopropenes is disclosed, the reaction scheme being as follows:

The invention provides a non-aqueous electrolyte of a lithium ion battery and the lithium ion battery, the electrolyte comprises: a first additive, the first additive comprises an isonitrile silane compound; the non-aqueous solvent at least comprises a first solvent, and the first solvent comprises a fluorosulfonamide compound; the fluorine sulfonamide compound comprises one or more of N, N-dimethyl trifluoromethanesulfonamide, 1-trifluoromethanesulfonyl-piperidine, N, N-diethyl trifluoromethanesulfonamide, N-methyl-N-ethyl trifluoromethanesulfonamide and 1-(trifluoromethanesulfonyl) pyrrolidine, and the fluorine sulfonamide compound comprises one or more of N, N-dimethyl trifluoromethanesulfonamide, 1-trifluoromethanesulfonyl-piperidine, N, N-diethyl trifluoromethanesulfonamide and 1-(trifluoromethanesulfonyl) pyrrolidine. The mass percent of the first solvent in the electrolyte is 25%-65%. Through the synergistic effect of the non-aqueous solvent and the additive, the electrolyte can form an interface phase with excellent thermal stability while maintaining high ionic conductivity, the fast charge cycle performance is remarkably improved, the thermal runaway temperature is increased, and then the unification of the fast charge performance and the thermal safety is realized.

The application discloses a preparation method and application of N-trifluoromethyl secondary amine compounds, and belongs to the technical field of fine chemical industry. The preparation method of the N-trifluoromethyl secondary amine compounds provided by the application comprises the following steps: isonitrile is used as a reaction substrate, and the reaction is carried out under the action of iodine, silver fluoride and tert-butyl dimethyl silane to obtain the N-trifluoromethyl secondary amine compounds. Compared with the prior art, the preparation method of the N-trifluoromethyl secondary amine compounds avoids the use of irritating toxic gases such as fluorine gas, hydrogen fluoride gas and sulfur light gas, effectively improves the experimental safety, and the reaction raw materials are easy to obtain, the product is easy to separate, and the reaction condition is mild, so that the application is a safer, more efficient and milder new method for preparing N-trifluoromethyl secondary amine compounds.

The invention relates to a fluorine-containing ionizable lipid compound, a preparation method and application thereof, and an LNP composition, and relates to the technical field of medical biologication.The fluorine-containing ionizable lipid compound is synthesized by taking an aldehyde compound, an amine compound, a carboxylic acid compound and an isonitrile compound as raw materials through a Ugi reaction; the obtained fluorine-containing ionizable lipid compound, sterol, auxiliary lipid and a polyethylene glycol lipid derivative form a lipid nanoparticle-like composition, and the composition can be used for drug delivery, including nucleic acid drugs such as small molecule drugs, mRNA, DNA and the like, protein / polypeptide drugs, and gene editing complexes such as mRNA / sgRNA, Cas9 / sgRNA and the like; the mRNA expression of different organs in an animal body is realized through different administration modes, and the application requirements of mRNA nucleic acid therapy, nucleic acid vaccines, gene editing and the like can be met.

The application discloses a method for preparing pyrrolopyridine derivatives by reacting conjugated diene functionalized isonitrile and methine isonitrile, and belongs to the technical field of organic synthesis. The conjugated diene functionalized isonitrile and the methine isonitrile are used as reaction substrates, silver carbonate is used as a catalyst, and the reaction is carried out in an organic solvent to obtain 1H-pyrrolo[2,3-c]pyridine derivatives; the structural formula of the 1H-pyrrolo[2,3-c]pyridine derivatives is shown in the description. The application uses two types of isonitrile compounds, and the 1H-pyrrolo[2,3-c]pyridine derivatives can be prepared at normal temperature and pressure without isolating water or oxygen. The reaction condition is mild, the operation is simple, the raw materials and reagents are simple and easy to obtain, the practicability is high, and the method is suitable for synthesizing various 1H-pyrrolo[2,3-c]pyridine derivatives.

The invention discloses a method for synthesizing guanidine compounds through electrochemical catalysis of benzotriazole and isocyanide, and belongs to the technical field of organic synthetic chemistry, and the method comprises the following steps: respectively adding benzotriazole, isocyanide and electrolyte into a three-necked bottle, adding a solvent for dissolving, taking a carbon rod as an anode and a platinum sheet as a cathode, and carrying out electrochemical catalysis on the mixture to obtain the guanidine compounds. Carrying out stirring reaction under the conditions of constant current and room temperature, and monitoring the reaction process by TLC (Thin Layer Chromatography); and after the reaction is completed, performing vacuum concentration, and purifying residues through column chromatography to obtain the target guanidine compound. The method for synthesizing the guanidine compound by electrochemical catalysis of benzotriazole and isonitrile does not need an exogenous oxidant, has the advantages of mild conditions, good tolerance of functional groups, simple post-treatment, high yield, easy product separation and the like, is high in atom economy and environment-friendly, conforms to the green organic synthesis concept, and is suitable for industrial production. A new path is opened up for green synthesis of guanidine compounds with pharmacological activity.

The invention discloses a method for preparing a 2-aminopyridine compound based on a dearomatization-aromatization strategy, and belongs to the technical field of organic synthesis. According to the present invention, pyridine is subjected to dearomatization under the mediation of DMAD / isocyanate, and then is subjected to aromatization under the alkali effect so as to highly selectively achieve the direct amination of the ortho-position C-H bond of pyridine, such that the 2-aminopyridine compound is obtained; according to the preparation method, metal catalysis is not needed, pyridine pre-activation is not needed, all used reagents are common reagents, operation is easy, and the yield is high. The obtained product 2-aminopyridine compound has wide application prospects in medicine, agriculture, materials and chemical synthesis.

The invention belongs to the technical field of optical functional material design and micro-nano processing, and particularly relates to a photoelectric device with a Raman temperature sensing characteristic and a preparation method of the photoelectric device with the Raman temperature sensing characteristic. Compared with a carbon nano tube (0.0288 cm <-1 > / DEG C) which also utilizes Raman shift as observed quantity, high sensitivity, high integration and high stability of the temperature sensor are realized, and in the aspect of SERS characteristics, the strength is improved by 9 times compared with that of a pure gold metal particle layer with the same thickness, so that the SERS performance of the temperature sensor is improved. According to the invention, the characteristic that the telescopic vibration frequency (Raman shift) of the N = C bond of an isocyanobenzene molecule changes along with the temperature is utilized, which is different from the anti-Stokes / Stokes peak intensity ratio (Ias / Is) temperature measurement principle of the traditional Raman temperature sensing; the temperature of the surface of the isocyanobenzene molecule can be reflected by utilizing the characteristic that the telescopic vibration frequency of the N = C bond of the isocyanobenzene molecule changes along with the temperature, and the spatial resolution can reach the nanoscale which is far superior to the micron-scale of the traditional optical fiber Raman temperature sensor, so that the spatial resolution is greatly improved, and the optical fiber Raman temperature sensor is suitable for being used in the field of optical fiber Raman temperature sensing. And a new platform is provided for designing a new generation of photonic devices, sensors and catalytic interfaces.

The application provides a new synthesis method of esacioxin intermediate. The method comprises the following steps: (1) reacting raw material 2-(trifluoromethyl) phenylacetic acid with ethyl chloroformate or isobutyl chloroformate in an inert solvent in the presence of a base to generate a mixed anhydride, and then reacting with ammonia to obtain a corresponding amide compound formula II; (2) preparing an isonitrile compound formula III through a dehydration reaction of the amide compound formula II obtained in the step (1) in the presence of a dehydrating agent and an acid binding agent; (3) cyclizing the isonitrile compound formula III obtained in the step (2) with 2-butynoic acid ethyl ester in the presence of a base and a metal catalyst to form a pyrrole ring compound formula IV; and the reaction formula is shown in the following formula: compared with the prior art, the technical scheme of the application has the advantages of high yield, simple post-treatment, low cost and easy industrialization.

The invention relates to the technical field of biology and new medicine, in particular to an organoid construction method and application thereof. The construction method of the organ is based on double factors of mechanics and biochemistry, spiral polyisocyanide serves as an extracellular matrix, and effective regulation and control of differentiation paths of cartilage organs and bone organs are achieved by adjusting the chain length and modifying RGD and cooperating with a cartilage generating cell population or an osteoblast population for differentiation.

This invention discloses a method for preparing isonitriles using photocatalysis with metalloporphyrin and metal phthalocyanine. The method comprises the following steps: mixing an organic amine with acetonitrile at a molar ratio of 1:(10-1000); adding metalloporphyrin and / or metal phthalocyanine to the mixture and dissolving or uniformly dispersing them by ultrasound or stirring; and subjecting the reaction to visible light irradiation at 0-20°C for 2-10 h in an oxygen-containing environment to obtain the isonitrile product corresponding to the organic amine. This method does not require harsh conditions such as high temperature and high pressure, nor does it require the addition of dehydrating agents, cyanides, or other external reagents. The reaction conditions are mild, the operation is simple, the yield is high, and the equipment requirements are low, exhibiting good safety and application value.

The application discloses a method for synthesizing a sulfoximine guanidine compound by using cobalt dichloride as a catalyst, and realizes efficient preparation of the sulfoximine guanidine compound through a free radical coupling reaction of a sulfoximine compound, an isonitrile compound and a sulfonyl azide compound. The method can effectively protect the guanidine group with high-valence sulfur, and has the advantages of mild reaction conditions, high synthesis efficiency, strong substrate universality, and high practical application value.

The application discloses a medical dressing containing seaweed extract and a preparation method thereof. The preparation method of the medical dressing containing seaweed extract comprises the following steps: under the action of sodium periodate, sodium alginate is subjected to an oxidation reaction to generate an oxidation derivative of sodium alginate; the oxidation derivative of sodium alginate is reacted with sodium alginate, chitosan and p-tolylsulfonylmethyl isocyanide to generate a seaweed acid derivative; the seaweed acid derivative is mixed with sodium alginate and deionized water to obtain a seaweed acid spinning solution; the seaweed acid spinning solution is spun into an electrostatic spinning fiber dressing through an electrostatic spinning process; the electrostatic spinning fiber dressing is placed in a calcium chloride solution for immersion; after the immersion is completed, the electrostatic spinning fiber dressing is washed, dried and the medical dressing containing seaweed extract is obtained. In the application, the seaweed acid spinning solution prepared has low conductivity, small surface tension and good electrostatic spinning performance, and the prepared medical dressing containing seaweed extract has good mechanical strength and excellent antibacterial property.