95 results about "Isocyanide" patented technology

The invention provides a positive pole piece, an electrochemical device and an electronic device, the positive pole piece comprises a positive current collector, a positive active material layer and a coating, the coating is located on the surface and / or inside the positive active material layer, and the coating comprises an organic compound, the organic compound comprises at least one functional group of a cyano group, an isonitrile group, an azinyl group and an isocyanate group, the thickness of the coating is 0.3-3 [mu] m, and the ratio of the thickness of the coating to the thickness of the positive electrode active material layer is 1: (5-50). The positive pole piece provided by the invention can improve the thermal safety, the high-temperature cycle performance, the high-temperature storage expansion rate and the mechanical safety of the electrochemical device.

The invention belongs to the technical field of biological medicines, and discloses lipid nanoparticles for muscle in-situ delivery as well as a preparation method and application of the lipid nanoparticles. According to the invention, four components Ugi of aldehyde, isonitrile, amine and carboxylic acid are subjected to a reaction to synthesize the ionizable cationic lipid. The ionizable cation lipid formed by introducing an ionizable cation head group into an isonitrile component has muscle in-situ nucleic acid delivery performance. The unsaturation degree of a lipid hydrophobic tail chain, the number of methylene spacers of an ionizable cation head group and LNP formula composition and process are further optimized, muscle in-situ selective mRNA delivery performance is enhanced, off-target liver expression is avoided, safety can be improved, and different application requirements of mRNA vaccines, nucleic acid drugs, gene editing and the like can be met.

The invention relates to a light-cured dental resin adhesive containing a silane coupling agent modified monomer as well as preparation and application of the light-cured dental resin adhesive. The dental resin adhesive comprises a resin matrix, an organic polymer and a photoinitiator, wherein the resin matrix consists of methacrylate resin grafted and modified by a silane coupling agent and unmodified methacrylate resin. According to the method, the isocyano group of the silane coupling agent is selected to react with the hydroxyl group on the resin monomer to generate the silane modified grafted resin monomer, and the method is simple, low in equipment requirement and suitable for large-scale production; the obtained dental resin adhesive can be internally covalently cross-linked to enhance the self mechanical property, can also be chemically bonded with a bonding substrate by utilizing a grafted silane coupling agent to improve the interface bonding strength, is especially suitable for being used as an enamel bonding material, and can remarkably improve the service life and the curative effect of a bonded restoration.

The invention relates to the technical field of electrolyte, in particular to a thioether cross-linked solid polymer electrolyte membrane as well as a preparation method and application thereof. The preparation method comprises the following steps: taking N, N-dimethylformamide, respectively adding 3, 6-dioxa-1, 8-octane dithiol and triglycidyl isocyanurate, and uniformly stirring to obtain a mixed solution; adding bis (trifluoromethylsulfonyl) imide lithium into the mixed solution, putting magnetons on a magnetic stirrer, and completely dissolving the magnetons to obtain a precursor solution; and pouring a proper amount of the precursor solution into a polytetrafluoroethylene mold, spreading, and carrying out cross-linking polymerization in a blast oven to form the film. The three-dimensional thioether cross-linked network structure has a large number of weakly coordinated thioether groups, dissociation of lithium salt can be promoted, a large number of free Li < + > is generated, the number of Li < + > is increased, meanwhile, the crystallinity of a polymer is remarkably reduced, the ionic conductivity is improved, the mechanical stability of a film can be improved, and the service life of a battery is effectively prolonged.

Methods of selectively depositing a passivation layer on a metal surface of a semiconductor substrate are described. Exemplary methods may include exposing the semiconductor substrate having a metal surface and a non-metal surface to a first precursor to form a first portion of the passivation layer on the metal surface, the first precursor including an isonitrile. The exemplary methods may further include exposing the semiconductor substrate comprising a metal surface and a non-metal surface to a second precursor to form the passivation layer on the metal surface. The second precursor may include an amine, an alcohol, or a thiol.

The application discloses a kind of tetrahydrocarbazole derivatives and its photocatalytic synthesis method, belong to organic synthesis technical field, 2-arylene phenyl isonitrile compound, cyclopropyl aniline compound and photocatalyst are added to solvent, after photocatalytic reaction, again separation and purification, obtain tetrahydrocarbazole derivative.This method is more simple compared with the method for using no tetrahydrocarbazole synthesis N-substituted tetrahydrocarbazole derivative, and no additional various additives in reaction, the atomic utilization rate of cyclopropyl aniline compound and 2-arylene phenyl isonitrile compound reaches 100%, reflects atomic economy, raw material is cheap and easy to obtain, reaction cost is low, and environment friendly;It is easy to operate, and target product can be efficiently obtained.The photocatalytic synthesis method of the tetrahydrocarbazole derivative is good in universality of raw material, and raw material is widely sourced, under optimized reaction condition, target product is easy to separate, and has potential application value in material and pharmaceutical field.

The application discloses a kind of all-substituted pyrrole compounds, the raw material alkyne compound of the application has structural diversity with isonitrile compound, can be used to synthesize different types and structures of all-substituted pyrrole compounds;Reaction raw material diphenylacetylene and its same type substrate compared with the raw material of the reaction reported by predecessors, have the advantages of simple and easy to obtain, stable nature;All-substituted pyrrole compounds have good diversity and functional group tolerance, so it has wide application;Further modification is carried out to different substitution sites on the heterocyclic skeleton of all-substituted pyrrole compounds, and intermediates of chemical products and drug structures can be obtained;The target product of the application takes pyrrole as the key mother nucleus, while amide and other unsaturated groups are introduced on the ring, and the structure has potential pharmacological activity;Cheap transition metal nickel is used as catalyst;The yield of the application is good.

The invention relates to synthesis of a tridentate bis (oxazoline phenyl) amino palladium metal methyl compound and preparation of a catalytic system, and belongs to the technical field of catalysts. The catalyst is used for catalyzing the polymerization reaction of isonitrile polymerization. A high-molecular-weight polymer can be obtained in the reaction process. The tridentate bis (oxazoline phenyl) amino palladium metal methyl compound catalytic system is obtained through one-step reaction, the raw materials are easy to obtain and modify, the economic efficiency is high, the catalyst does not need complex synthesis steps, the environmental protection property is good, and the tridentate bis (oxazoline phenyl) amino palladium metal methyl compound catalytic system is suitable for industrial production. The work provides a new thought for a new catalyst system.

This article relates to a method for preparing phenanthridine. The invention involves converting biphenyl isonitriles into polysubstituted phenanthridines and their derivatives under photocatalysis and blue light in an argon atmosphere, yielding molecules with stable structures and excellent chemical properties. The synthetic method utilizes inexpensive and readily available raw materials; the reaction requires only a photocatalyst, additives, and blue light, thus saving raw materials and reducing reaction costs. The entire reaction system is simple, the reaction conditions are mild, the required equipment is minimal, the experimental operation is straightforward, and the yield is moderate to high.

Methods and apparatuses for using molecules having a carbon-nitrogen triple bond as inhibitors on metal-containing surfaces to selectively deposit dielectric material on a dielectric surface on a substrate surface having a metal-containing surface and a dielectric surface are provided. A method for processing substrates comprises providing a substrate having a first material and a second material thereon to a process chamber, exposing the substrate to an isonitrile inhibitor to adsorb onto the first material to inhibit deposition on the first material, and depositing a dielectric film on the second material.

Described herein are steroid or steroid-like compounds including at least one isonitrile group and which inhibit the activity of a cytochrome P450 enzyme, as well as compositions including the compounds. Also included are methods of inhibiting activity of a cytochrome P450 in a subject having a steroid-responsive cancer, a Mycobacterium tuberculosis infection, a fungal infection, or a trypanosome infection, the method comprising administering to the subject the compound including at least one isonitrile group or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit the CYP activity in the subject.

Compounds of Formula I,are provided. In Formula I, M is Pd or Pt; each of X1 to X14 is C or N; one of Z1 and Z2 is C and the other is N; Y is selected from O, S, Se, N*R, CRR′, SiRR′, or GeRR′; K1 is a direct bond, O, or S; each R, R′, RA, RB, RC, and RD is independently hydrogen or a substituent; at least one of R, R′, RA, RB, RC, or RD is a substituent R*; and (i) R* comprises a 5-membered or 6-membered heterocyclic ring, or (ii) R* comprises Formula Ia:Formula Ia;wherein each of RY and RZ independently represents mono to the maximum allowable substitution, or no substitution;R1, R2, R3, R4, RY and RZ is independently hydrogen or a substituent selected from the group consisting of deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, germyl, boryl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carboxylic acid, ether, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, boryl, selenyl, and combinations thereof;wherein at least one of R1, R2, R3, and R4 is not hydrogen. Formulations, OLEDs, and consumer products including the compound are also provided.

The invention relates to the technical field of agricultural plant growth regulators, and discloses a phosphate compound containing an amide group as well as a preparation method and application thereof. O-aminopyridine, different substituted benzaldehyde and isocyanide are used as initial raw materials, and ring closing and ring opening are performed to obtain the phosphate compound containing the amide group. And finally, reacting with dialkyl phosphite to obtain the phosphate ester compound containing the amide group. The phosphate ester compound containing the amide group is high in activity, high in stability, simple in synthesis route and low in cost, can serve as an ABA analogue to be combined with abscisic acid receptor (PYL3) protein, can promote plant stomata closing and regulate crop root growth, and can be used as an abscisic acid receptor (PYL3) protein. Further, the drought stress regulation capability of the plants is improved.

Methods of selectively depositing a passivation layer on a metal surface of a semiconductor substrate are described. Exemplary methods may include exposing the semiconductor substrate having a metal surface and a non-metal surface to a first precursor to form a first portion of the passivation layer on the metal surface, the first precursor including an isonitrile. The exemplary methods may further include exposing the semiconductor substrate comprising a metal surface and a non-metal surface to a second precursor to form the passivation layer on the metal surface. The second precursor may include an amine, an alcohol, or a thiol.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of long-chain fatty amine, acylamino long-chain fatty acid, long-chain omega-amino fatty acid and long-chain nylon. The preparation method of the long-chain fatty amine comprises the following steps: mixing sodium hypohalide and an organic solvent, and carrying out Hofmann rearrangement reaction to obtain a transition-state reaction solution; and then adjusting the transition state reaction liquid to be alkaline, and carrying out hydrolysis reaction to obtain the long-chain fatty amine. Wherein the structural formula of the long-chain fatty amine is shown in the specification, and n represents an even number of 8-14; the transition state reaction liquid comprises an isocyanate intermediate; and the organic solvent is mutually soluble with water. According to the invention, long-chain fatty amine is prepared from renewable long-chain fatty acid, and precursor substances of long-chain nylon such as nylon 11 and the like are prepared by adopting a chemical and microbial coupling method.

The invention discloses a method for catalytic synthesis of sulfoximine guanidine compounds by cobalt dichloride, which realizes efficient preparation of the sulfoximine guanidine compounds by taking cobalt dichloride as a catalyst and through free radical coupling reaction of sulfoximine compounds, isonitrile compounds and sulfonyl azide compounds. The method can effectively protect high-valence thioguanidyl, has the advantages of mild reaction conditions, high synthesis efficiency and strong substrate universality, and has extremely high practical application value.

The invention relates to the technical field of lithium ion solid-state batteries, in particular to a lithium ion solid-state battery and a preparation method thereof. The lithium ion solid-state battery comprises a positive pole piece, a solid-state polymer electrolyte membrane and a lithium metal negative pole piece which are assembled together, the preparation method of the polymer electrolyte membrane comprises the following steps: respectively adding 3, 6-dioxa-1, 8-octane dithiol and triglycidyl isocyanurate into a solvent, and stirring to obtain a mixed solution; adding bis (trifluoromethylsulfonyl) imide lithium into the mixed solution, and dissolving to obtain a precursor solution; and carrying out cross-linking polymerization on the precursor solution to form the film. The lithium ion solid-state battery provided by the invention shows excellent capacity, excellent cycling stability and reversibility.

The invention discloses a polyoxazoline block polyisocyanide copolymer and a preparation method thereof, the structural general formula of the polyoxazoline block polyisocyanide copolymer is shown in the specification, the polymerization degree m is equal to 10-100, m is an integer, n is equal to 10-400, and n is an integer; r1 is one of R1 and R2. The molecular weight of the prepared polyoxazoline block polyisocyanide copolymer is controllable, the polyoxazoline block polyisocyanide copolymer is easy to modify, and the polyoxazoline block polyisocyanide copolymer has wide application prospects in the fields of chiral assembly, asymmetric catalysis, chiral separation, drug controlled release and the like.

The invention belongs to the technical field of organic synthesis, and discloses a method for synthesizing gamma-lactam derivatives through cobalt catalytic cyclization. The method comprises the following steps: in a protective atmosphere, taking an organic solvent as a reaction medium, and reacting a propyne compound with an isonitrile compound and a carboxylic acid compound under the action of a catalyst, a ligand and alkali to obtain the unsaturated gamma-lactam derivative. The catalyst is a cobalt catalyst, and the ligand is a nitrogen or phosphine compound. The method disclosed by the invention is simple, low in cost, efficient in reaction, few in byproducts, easy to separate and purify and high in yield.

This invention discloses a α The electrosynthesis method of α-aminomethyltetrazole includes: using a platinum sheet as the cathode and a carbon rod as the anode, and employing ammonium tetrabutyltetrafluoroborate as the electrolyte under constant current catalysis, a one-pot coupling of a tertiary amine, an isonitrile, and azide trimethylsilane to prepare the α-aminomethyltetrazole. α The step involving the aminomethyltetrazole derivative, followed by post-treatment and column chromatography separation of the resulting reaction mixture, yields... α - Pure aminomethyltetrazole. This invention yields it through a single reaction step. α -Aminomethyltetrazole has fewer operating steps, avoids the use of large amounts of oxidants and additives, simplifies post-processing, and makes the product easy to separate.

The present invention discloses a method for preparing a series of vonoprazan intermediates using an isonitrile and a Michael acceptor. In the method of the present invention, α-(p-toluenesulfonyl)-2-fluorobenzylisonitrile is used as the starting material, which attacks a series of Michael acceptors under basic conditions and undergoes cyclization to form a series of 3-substituted 5-(2-fluorophenyl)-1H-pyrroles. These 3-substituted pyrrole intermediates can be further chemically transformed to prepare vonoprazan. Compared with the prior art, the technical means of the present invention are characterized by a short synthetic route, high overall yield, simple post-treatment, and low cost.

This invention discloses a method for synthesizing 6-arylphenanthrene diphenyl compounds. The method involves a dehydrazine radical tandem addition-cyclization reaction of 2-isocyanuric biphenyl and arylhydrazine under air atmosphere and blue visible light irradiation, catalyzed by a molybdenum sulfide / N-hydroxyphthalimide synergistic catalytic system, to generate 6-arylphenanthrene diphenyl compounds. This method has the advantages of readily available raw materials, simple operation, mild reaction conditions, high reaction selectivity and yield, and excellent substrate functional group compatibility.

A method for synthesising polyurethane foam compositions convenient for use in areas wherein rigidity and lightness are required together in automotive sector and including the steps of: conduct of polyol dosage adjustment, adding inflating reaction catalyser onto polyol of convenient amount and mixing at mechanical mixture, adding glycerine while mixing is continued, adding surfactive while mixing is continued, adding gelling reaction catalyser while mixing is continued, adding cell opening agent while mixing is continued, adding cell opening agent while mixing is continued, adding at least an inflating agent selected from a group consisting of n-pentane, cyclo-pentane, C3H8O2 gas and C2H4O2 gas while mixing is continued, conduct of temperature adjustment of polyol base mixture, conduct of isocyanide dosage adjustment in a separate place, injecting polyol base mixture into reaction container from one side and isocyanides from other side, conduct of temperature control during reaction and opening mold and removing final product.

The invention relates to synthesis of a circularly polarized light isonitrile material with multi-stimulus response and all-light-white light regulation and control, and belongs to the field of intelligent high polymer materials. According to the covalent construction strategy, multi-adjustable CPL from molecular design to supramolecular assembly is achieved, and due to the fact that the azobenzene side group is subjected to reversible cis-reflective isomerization under stimulation of light, pH, metal ions and humidity, the material is endowed with various responsive CPL characteristics; the method has potential application value in multicolor dynamic display, anti-counterfeiting security, information encryption and chiral logic gate application. This work provides a basic insight for covalently constructing static helical polymers with dynamically tunable CPL.

The application discloses a preparation method and application of a photocatalytic synthesis of nitrogen heteroaromatic compound, and the nitrogen heteroaromatic compound is obtained by mixing isonitrile compound, alkyl boronic acid reagent, photosensitizer, alkali reagent and solvent and then performing a reaction under irradiation of visible light. The synthesis method has the advantages of easy availability of raw materials, simple operation, mild reaction and wide applicability of substrates, and the obtained indole / pyrrolo[1,2-a]quinoxaline compound has fluorescence performance.

The invention relates to the technical field of biological medicine, and discloses a neutral lipid for mRNA delivery, a two-component lipid nanoparticle, a preparation method and application, and the preparation method comprises the following steps: the neutral lipid is obtained through a Ugi reaction of amine, carboxylic acid, aldehyde and isocyanide compounds; wherein the amine is polyethylene glycol-terminated amine, the carboxylic acid is a uracil carboxylic acid derivative, the aldehyde is one of C12, C18 and oleic acid chain aldehydes, and the isocyanide compound is one of C12, C18 and oleic acid chain isocyanide compounds; according to the neutral lipid structure prepared by the invention, a basic group complementary pairing delivery mechanism of uracil and polyA tail of mRNA is used for replacing a traditional model of combining electrostatic interaction of cationic lipid with mRNA, so that the problem of related inflammatory toxicity caused by cationic charges existing in ionized lipid is solved. Neutral lipid and cholesterol form novel two-component LNP, and efficient delivery of mRNA can be achieved.

The invention provides chiral spiral polyisocyanide with a sulfonamide structure as well as a preparation method and application of the chiral spiral polyisocyanide, and belongs to the technical field of high polymer materials. The preparation method comprises the following steps: carrying out nucleophilic fluorine exchange reaction on chiral alpha-phenylethylamine and sulfonyl fluoride isocyanide to prepare a sulfonamide modified isocyanide monomer, and initiating the activity of the monomer by adopting a nickel / palladium catalyst to carry out polymerization reaction, thereby preparing the chiral spiral polyisocyanide with a sulfonamide structure. The chiral spiral polyisocyanide with the sulfonamide structure has excellent stability and anti-interference capability, has high specificity to fluorine anions, generates macroscopic color change under visible light, disappears circular dichroism spectrum signals, and has wide application prospects in the field of fluorine ion recognition and detection.

The application discloses a polythiazole compound and a preparation method and application thereof; a structural formula of the polythiazole compound is as shown in formula I, formula II and formula III. The preparation method comprises the following steps: reacting a polybasic alkenone compound, a polybasic isonitrile compound and elemental sulfur under the catalysis of an alkali to obtain the polythiazole compound. The preparation method is mild in conditions, efficient in reaction, high in yield, novel in product structure, can avoid the use of dangerous reagents, and can realize in-situ construction of the polythiazole compound; and the polythiazole compound has high molecular weight, photoluminescence and high refractive performance.

The invention discloses a synthesis method of N, N '-[(4-diazo-4H-pyrazole-3, 5-diyl) bis (1, 2, 5-oxadiazole-4, 3-diyl)] dinitramide, which is realized by the following steps: step 1, preparing a diazepine intermediate product through [4 + 1] cycloaddition reaction participated by isocyanide; step 2, hydrolyzing the diazepine intermediate product under the condition of concentrated hydrochloric acid to prepare 4, 4 '-(4-amino-1H-pyrazole-3, 5-diyl) bis (1, 2, 5-oxadiazole-3-amine); and step 3, preparing a target product by nitration under a nitric acid condition. The invention provides an energetic compound with high thermal stability, low sensitivity and high detonation performance, effectively breaks through the technical bottleneck of the existing energetic material in the aspect of energy and stability balance, and has a considerable application prospect in the field of novel energetic materials.