131 results about "Isocyanide" patented technology

The invention provides a positive pole piece, an electrochemical device and an electronic device, the positive pole piece comprises a positive current collector, a positive active material layer and a coating, the coating is located on the surface and / or inside the positive active material layer, and the coating comprises an organic compound, the organic compound comprises at least one functional group of a cyano group, an isonitrile group, an azinyl group and an isocyanate group, the thickness of the coating is 0.3-3 [mu] m, and the ratio of the thickness of the coating to the thickness of the positive electrode active material layer is 1: (5-50). The positive pole piece provided by the invention can improve the thermal safety, the high-temperature cycle performance, the high-temperature storage expansion rate and the mechanical safety of the electrochemical device.

The invention belongs to the technical field of biological medicines, and discloses lipid nanoparticles for muscle in-situ delivery as well as a preparation method and application of the lipid nanoparticles. According to the invention, four components Ugi of aldehyde, isonitrile, amine and carboxylic acid are subjected to a reaction to synthesize the ionizable cationic lipid. The ionizable cation lipid formed by introducing an ionizable cation head group into an isonitrile component has muscle in-situ nucleic acid delivery performance. The unsaturation degree of a lipid hydrophobic tail chain, the number of methylene spacers of an ionizable cation head group and LNP formula composition and process are further optimized, muscle in-situ selective mRNA delivery performance is enhanced, off-target liver expression is avoided, safety can be improved, and different application requirements of mRNA vaccines, nucleic acid drugs, gene editing and the like can be met.

The invention relates to a light-cured dental resin adhesive containing a silane coupling agent modified monomer as well as preparation and application of the light-cured dental resin adhesive. The dental resin adhesive comprises a resin matrix, an organic polymer and a photoinitiator, wherein the resin matrix consists of methacrylate resin grafted and modified by a silane coupling agent and unmodified methacrylate resin. According to the method, the isocyano group of the silane coupling agent is selected to react with the hydroxyl group on the resin monomer to generate the silane modified grafted resin monomer, and the method is simple, low in equipment requirement and suitable for large-scale production; the obtained dental resin adhesive can be internally covalently cross-linked to enhance the self mechanical property, can also be chemically bonded with a bonding substrate by utilizing a grafted silane coupling agent to improve the interface bonding strength, is especially suitable for being used as an enamel bonding material, and can remarkably improve the service life and the curative effect of a bonded restoration.

The invention discloses a synthesis method of an N-formamide derivative, and belongs to the technical field of chemical synthesis, the N-formamide derivative is obtained by a one-step method by taking an isonitrile compound as a substrate and a titanocene compound as a catalyst and carrying out hydrolysis reaction in an organic solvent at room temperature and normal pressure. According to the method, the titanocene compound is used as a catalyst, and the hydrolysis reaction is selectively terminated to the step of generating the formamide compound in the isonitrile compound hydrolysis process, so that the isonitrile compound is prevented from being further hydrolyzed to generate the amine compound. The method has the advantages of simple reaction process, cheap and easily available reaction system, wide substrate range, mild reaction conditions, high target product yield and no burden on the environment.

The invention relates to the technical field of electrolyte, in particular to a thioether cross-linked solid polymer electrolyte membrane as well as a preparation method and application thereof. The preparation method comprises the following steps: taking N, N-dimethylformamide, respectively adding 3, 6-dioxa-1, 8-octane dithiol and triglycidyl isocyanurate, and uniformly stirring to obtain a mixed solution; adding bis (trifluoromethylsulfonyl) imide lithium into the mixed solution, putting magnetons on a magnetic stirrer, and completely dissolving the magnetons to obtain a precursor solution; and pouring a proper amount of the precursor solution into a polytetrafluoroethylene mold, spreading, and carrying out cross-linking polymerization in a blast oven to form the film. The three-dimensional thioether cross-linked network structure has a large number of weakly coordinated thioether groups, dissociation of lithium salt can be promoted, a large number of free Li < + > is generated, the number of Li < + > is increased, meanwhile, the crystallinity of a polymer is remarkably reduced, the ionic conductivity is improved, the mechanical stability of a film can be improved, and the service life of a battery is effectively prolonged.

The invention discloses fireproof flame-retardant phenolic resin and a preparation method thereof, and relates to the technical field of high polymer materials. When the fireproof flame-retardant phenolic resin is prepared, firstly, alkali lignin is depolymerized in a lithium bromide solution, and depolymerized lignin is prepared; carrying out multi-component reaction on the depolymerized lignin, amino-terminated polydimethylsiloxane, isonitrile diethyl methylphosphate and glacial acetic acid to prepare modified lignin; the preparation method comprises the following steps: carrying out reaction modification on montmorillonite and diisocyanate to prepare isocyanate modified montmorillonite; the isocyanate modified montmorillonite and 3-aminopropyltriethoxysilane are subjected to a reaction, and modified montmorillonite is prepared; and polymerizing phenol with the modified lignin, paraformaldehyde and modified montmorillonite, and discharging to obtain the fireproof flame-retardant phenolic resin. The prepared fireproof flame-retardant phenolic resin has the advantages of flame retardance, good toughness, high strength and aging resistance.

The invention discloses a large-steric-hindrance nitrile compound and a preparation method and application thereof.The preparation method comprises the steps that indole carbonate and benzyl isocyanide serve as reaction raw materials, and the nitrile compound with a large-steric-hindrance quaternary carbon center is prepared through a one-pot method in the presence of a metal salt catalyst and a solvent; the invention provides a large-steric-hindrance nitrile compound which has the advantages of higher step economy, atom economy, convenience in post-treatment, rapidness and high efficiency. The high-steric-hindrance nitrile compound is constructed in one step by using simple raw materials, has the advantages of cheap and easily available raw materials, simple and mild conditions, high atom economy, excellent yield and wide substrate range, provides a green synthesis method for efficient construction of a high-steric-hindrance nitrile compound skeleton, and is convenient for preparation of the high-steric-hindrance nitrile compound and application of the high-steric-hindrance nitrile compound in the field of drug preparation.

The invention relates to the technical field of radiopharmaceutical chemistry and clinical nuclear medicine, in particular to preparation and application of isonitrile mannose cuprous complex salt derivatives. The structure of the isonitrile mannose cuprous complex salt derivative is shown in (I), the isonitrile mannose cuprous complex salt derivative is good in stability, a marking method is simple when a freeze-drying medicine box prepared from the isonitrile mannose cuprous complex salt derivative is used for preparing < 99m > Tc tumor marking radiopharmaceuticals, the marking rate of a final product is larger than 90%, the tumor affinity performance is good, and clinical application and popularization are convenient. # imgabs0 #

The invention discloses a supporting layer suitable for a composite current collector, a corresponding composite current collector and a battery. Wherein the supporting layer is formed by curing insulating adhesive liquid; the insulating adhesive liquid comprises a component A and a component B which are mixed, wherein the component A is at least one of polyurethane resin, acrylic resin, epoxy resin, polyester resin, polyimide, an organosilicon polymer and a modified compound thereof; the liquid B is at least one of amino resin, isocyanate, an aziridine cross-linking agent, carbodiimide, a silane coupling agent and an organic silicon tackifier; wherein the ratio of the component A to the component B is (90-99): (1-5). Compared with an existing supporting layer and an existing composite current collector, the viscous insulating layer structure can replace common PET, PP, PI and other types of base film middle supporting layer structures, the adhesive strength of the metal layer and the supporting layer is improved, and meanwhile additional hierarchical structures are avoided. And the production process is simplified, so that mass production is realized.

Methods of selectively depositing a passivation layer on a metal surface of a semiconductor substrate are described. Exemplary methods may include exposing the semiconductor substrate having a metal surface and a non-metal surface to a first precursor to form a first portion of the passivation layer on the metal surface, the first precursor including an isonitrile. The exemplary methods may further include exposing the semiconductor substrate comprising a metal surface and a non-metal surface to a second precursor to form the passivation layer on the metal surface. The second precursor may include an amine, an alcohol, or a thiol.

The application discloses a kind of tetrahydrocarbazole derivatives and its photocatalytic synthesis method, belong to organic synthesis technical field, 2-arylene phenyl isonitrile compound, cyclopropyl aniline compound and photocatalyst are added to solvent, after photocatalytic reaction, again separation and purification, obtain tetrahydrocarbazole derivative.This method is more simple compared with the method for using no tetrahydrocarbazole synthesis N-substituted tetrahydrocarbazole derivative, and no additional various additives in reaction, the atomic utilization rate of cyclopropyl aniline compound and 2-arylene phenyl isonitrile compound reaches 100%, reflects atomic economy, raw material is cheap and easy to obtain, reaction cost is low, and environment friendly;It is easy to operate, and target product can be efficiently obtained.The photocatalytic synthesis method of the tetrahydrocarbazole derivative is good in universality of raw material, and raw material is widely sourced, under optimized reaction condition, target product is easy to separate, and has potential application value in material and pharmaceutical field.

The present invention relates to the fields of pharmaceutical engineering and medical technology, and particularly to a compound with anti-lung cancer activity, a preparation method thereof, and an application thereof. In the present invention, an ionic liquid is used as a solvent, and Z-2-chloromethyl-3-phenylacrylic acid, 3-p-chlorophenylacrolein, benzylamine, and cyclohexyl isocyanide are used as raw materials, and a compound with anti-lung cancer activity is obtained through a microwave-assisted one-pot reaction. The method of the present invention has the characteristics of simplicity, low cost, and greenness, and the prepared compound with anti-lung cancer activity has a good effect of inhibiting the proliferation and inducing apoptosis of lung cancer cells.

The application discloses a kind of all-substituted pyrrole compounds, the raw material alkyne compound of the application has structural diversity with isonitrile compound, can be used to synthesize different types and structures of all-substituted pyrrole compounds;Reaction raw material diphenylacetylene and its same type substrate compared with the raw material of the reaction reported by predecessors, have the advantages of simple and easy to obtain, stable nature;All-substituted pyrrole compounds have good diversity and functional group tolerance, so it has wide application;Further modification is carried out to different substitution sites on the heterocyclic skeleton of all-substituted pyrrole compounds, and intermediates of chemical products and drug structures can be obtained;The target product of the application takes pyrrole as the key mother nucleus, while amide and other unsaturated groups are introduced on the ring, and the structure has potential pharmacological activity;Cheap transition metal nickel is used as catalyst;The yield of the application is good.

The invention relates to synthesis of a tridentate bis (oxazoline phenyl) amino palladium metal methyl compound and preparation of a catalytic system, and belongs to the technical field of catalysts. The catalyst is used for catalyzing the polymerization reaction of isonitrile polymerization. A high-molecular-weight polymer can be obtained in the reaction process. The tridentate bis (oxazoline phenyl) amino palladium metal methyl compound catalytic system is obtained through one-step reaction, the raw materials are easy to obtain and modify, the economic efficiency is high, the catalyst does not need complex synthesis steps, the environmental protection property is good, and the tridentate bis (oxazoline phenyl) amino palladium metal methyl compound catalytic system is suitable for industrial production. The work provides a new thought for a new catalyst system.

This article relates to a method for preparing phenanthridine. The invention involves converting biphenyl isonitriles into polysubstituted phenanthridines and their derivatives under photocatalysis and blue light in an argon atmosphere, yielding molecules with stable structures and excellent chemical properties. The synthetic method utilizes inexpensive and readily available raw materials; the reaction requires only a photocatalyst, additives, and blue light, thus saving raw materials and reducing reaction costs. The entire reaction system is simple, the reaction conditions are mild, the required equipment is minimal, the experimental operation is straightforward, and the yield is moderate to high.

Methods and apparatuses for using molecules having a carbon-nitrogen triple bond as inhibitors on metal-containing surfaces to selectively deposit dielectric material on a dielectric surface on a substrate surface having a metal-containing surface and a dielectric surface are provided. A method for processing substrates comprises providing a substrate having a first material and a second material thereon to a process chamber, exposing the substrate to an isonitrile inhibitor to adsorb onto the first material to inhibit deposition on the first material, and depositing a dielectric film on the second material.

Described herein are steroid or steroid-like compounds including at least one isonitrile group and which inhibit the activity of a cytochrome P450 enzyme, as well as compositions including the compounds. Also included are methods of inhibiting activity of a cytochrome P450 in a subject having a steroid-responsive cancer, a Mycobacterium tuberculosis infection, a fungal infection, or a trypanosome infection, the method comprising administering to the subject the compound including at least one isonitrile group or a pharmaceutically acceptable salt thereof, in an amount effective to inhibit the CYP activity in the subject.

Compounds of Formula I,are provided. In Formula I, M is Pd or Pt; each of X1 to X14 is C or N; one of Z1 and Z2 is C and the other is N; Y is selected from O, S, Se, N*R, CRR′, SiRR′, or GeRR′; K1 is a direct bond, O, or S; each R, R′, RA, RB, RC, and RD is independently hydrogen or a substituent; at least one of R, R′, RA, RB, RC, or RD is a substituent R*; and (i) R* comprises a 5-membered or 6-membered heterocyclic ring, or (ii) R* comprises Formula Ia:Formula Ia;wherein each of RY and RZ independently represents mono to the maximum allowable substitution, or no substitution;R1, R2, R3, R4, RY and RZ is independently hydrogen or a substituent selected from the group consisting of deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, germyl, boryl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carboxylic acid, ether, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, boryl, selenyl, and combinations thereof;wherein at least one of R1, R2, R3, and R4 is not hydrogen. Formulations, OLEDs, and consumer products including the compound are also provided.

The invention relates to the technical field of agricultural plant growth regulators, and discloses a phosphate compound containing an amide group as well as a preparation method and application thereof. O-aminopyridine, different substituted benzaldehyde and isocyanide are used as initial raw materials, and ring closing and ring opening are performed to obtain the phosphate compound containing the amide group. And finally, reacting with dialkyl phosphite to obtain the phosphate ester compound containing the amide group. The phosphate ester compound containing the amide group is high in activity, high in stability, simple in synthesis route and low in cost, can serve as an ABA analogue to be combined with abscisic acid receptor (PYL3) protein, can promote plant stomata closing and regulate crop root growth, and can be used as an abscisic acid receptor (PYL3) protein. Further, the drought stress regulation capability of the plants is improved.

Methods of selectively depositing a passivation layer on a metal surface of a semiconductor substrate are described. Exemplary methods may include exposing the semiconductor substrate having a metal surface and a non-metal surface to a first precursor to form a first portion of the passivation layer on the metal surface, the first precursor including an isonitrile. The exemplary methods may further include exposing the semiconductor substrate comprising a metal surface and a non-metal surface to a second precursor to form the passivation layer on the metal surface. The second precursor may include an amine, an alcohol, or a thiol.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of long-chain fatty amine, acylamino long-chain fatty acid, long-chain omega-amino fatty acid and long-chain nylon. The preparation method of the long-chain fatty amine comprises the following steps: mixing sodium hypohalide and an organic solvent, and carrying out Hofmann rearrangement reaction to obtain a transition-state reaction solution; and then adjusting the transition state reaction liquid to be alkaline, and carrying out hydrolysis reaction to obtain the long-chain fatty amine. Wherein the structural formula of the long-chain fatty amine is shown in the specification, and n represents an even number of 8-14; the transition state reaction liquid comprises an isocyanate intermediate; and the organic solvent is mutually soluble with water. According to the invention, long-chain fatty amine is prepared from renewable long-chain fatty acid, and precursor substances of long-chain nylon such as nylon 11 and the like are prepared by adopting a chemical and microbial coupling method.

The invention discloses a method for catalytic synthesis of sulfoximine guanidine compounds by cobalt dichloride, which realizes efficient preparation of the sulfoximine guanidine compounds by taking cobalt dichloride as a catalyst and through free radical coupling reaction of sulfoximine compounds, isonitrile compounds and sulfonyl azide compounds. The method can effectively protect high-valence thioguanidyl, has the advantages of mild reaction conditions, high synthesis efficiency and strong substrate universality, and has extremely high practical application value.

The invention relates to the technical field of lithium ion solid-state batteries, in particular to a lithium ion solid-state battery and a preparation method thereof. The lithium ion solid-state battery comprises a positive pole piece, a solid-state polymer electrolyte membrane and a lithium metal negative pole piece which are assembled together, the preparation method of the polymer electrolyte membrane comprises the following steps: respectively adding 3, 6-dioxa-1, 8-octane dithiol and triglycidyl isocyanurate into a solvent, and stirring to obtain a mixed solution; adding bis (trifluoromethylsulfonyl) imide lithium into the mixed solution, and dissolving to obtain a precursor solution; and carrying out cross-linking polymerization on the precursor solution to form the film. The lithium ion solid-state battery provided by the invention shows excellent capacity, excellent cycling stability and reversibility.

The present invention discloses a multiple non-covalent bond enhanced pH / glucose-responsive Pickering emulsion, its preparation and application, which relates to the technical field of Pickering emulsions. The preparation method of the Pickering emulsion comprises the following steps: S1: reacting 3-aminophenylboronic acid hydrochloride, sodium alginate and cyclohexyl isocyanide to obtain a phenylboronic acid-based sodium alginate derivative; S2: adding diacylated anthocyanins from purple sweet potato to soy protein isolate after hydration and degradation treatment, and mixing them to obtain soy protein isolate-diacylated anthocyanins from purple sweet potato; S3: ultrasonically mixing the phenylboronic acid-based sodium alginate derivative and soy protein isolate-diacylated anthocyanins from purple sweet potato, and then homogenizing with squalene to obtain the Pickering emulsion. The Pickering emulsion of the present invention, as a supramolecular hierarchical stimulus-responsive Pickering emulsion system for targeted delivery systems, not only provides new ideas for the delivery of biofunctional compounds, enhances the corresponding bioavailability, but also builds a bridge between colloid interface chemistry and drug delivery systems.

The invention discloses a polyoxazoline block polyisocyanide copolymer and a preparation method thereof, the structural general formula of the polyoxazoline block polyisocyanide copolymer is shown in the specification, the polymerization degree m is equal to 10-100, m is an integer, n is equal to 10-400, and n is an integer; r1 is one of R1 and R2. The molecular weight of the prepared polyoxazoline block polyisocyanide copolymer is controllable, the polyoxazoline block polyisocyanide copolymer is easy to modify, and the polyoxazoline block polyisocyanide copolymer has wide application prospects in the fields of chiral assembly, asymmetric catalysis, chiral separation, drug controlled release and the like.

The invention belongs to the technical field of organic synthesis, and discloses a method for synthesizing gamma-lactam derivatives through cobalt catalytic cyclization. The method comprises the following steps: in a protective atmosphere, taking an organic solvent as a reaction medium, and reacting a propyne compound with an isonitrile compound and a carboxylic acid compound under the action of a catalyst, a ligand and alkali to obtain the unsaturated gamma-lactam derivative. The catalyst is a cobalt catalyst, and the ligand is a nitrogen or phosphine compound. The method disclosed by the invention is simple, low in cost, efficient in reaction, few in byproducts, easy to separate and purify and high in yield.

The invention relates to organic electroluminescent materials and devices. The present invention provides a compound having a first ligand LA comprising the structure of Formula I: # imgabs0 # in Formula I, at least one of the following is true: (1) RC comprises at least one silyl group or germanium alkyl group; or (2) RC is formula II # imgabs1 # with the proviso that Y2 and RB are not joined to form a ring; and if part D is phenyl; if at least one RD contains one chemical group selected from the group consisting of deuterium, halogen, alkyl having five or more carbon atoms, cycloalkyl, heteroalkyl, heterocycloalkyl, aralkyl, alkoxy, aryloxy, amino, silyl, germanyl, boryl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carboxylic acid, ether, ester, nitrile, isonitrile, sulfanyl, r1, R2, R3, R4, R5, R6, R7, R7, R7, R8, R8, R8, R8, R8, formulations, OLEDs, and consumer products containing the compounds are also provided.

The present invention discloses a cholesteryl terminal alkyne-functionalized helical polyisocyanide polymer as a liquid crystal alignment medium, and its preparation method and application, belonging to the technical field of organic analysis. The structure of the helical polymer poly-2 is shown as follows: It is obtained by adding a chiral isocyanide monomer to initiate a reaction in a polymerization flask using cholesteryl terminal alkyne palladium(II) as a catalyst. The polymer is rapidly self-assembled in deuterated dichloromethane to construct a novel lyotropic liquid crystal alignment medium. This polymer chiral alignment medium can effectively align natural product organic small molecules to achieve accurate determination of nuclear magnetic resonance residual dipolar coupling for chiral recognition and analysis of organic molecules. Its preparation method is simple and the alignment strength is appropriate, making the spectral signals in the determination of nuclear magnetic resonance residual dipolar coupling clear and avoiding interference from background signals to the spectral analysis; moreover, as a chiral alignment medium, it has excellent chiral recognition performance, laying a foundation for the determination of the absolute configuration of organic molecules or natural products.

The invention belongs to the technical field of organic synthetic chemistry, and discloses an efficient synthesis method of an indoline and azepine ketone derivative. The derivative has a structure as shown in a formula (I), and is prepared according to the following steps: reacting 1 equivalent of carboxylic acid, 1 equivalent of o-alkynylaniline, 1 equivalent of pyridine-2-formaldehyde and 1 equivalent of isocyanide as reaction raw materials at room temperature for 5 hours under the condition that methanol is used as a solvent to obtain an intermediate Ugi compound. Then, spin-drying a reaction solvent, adding n-butyl alcohol (1.5 mL), XPhosAuCl (0.01 mmol, 0.05 equivalent) and silver acetate (0.01 mmol, 0.05 equivalent), and transferring a reaction system to a microwave condition of 110 DEG C to react for 1 hour, so as to finally obtain the indoline and azepine ketone derivative as shown in the formula (I). The indoline azepine ketone derivative is efficiently prepared through a one-pot method, the compound is a quasi-natural product compound with a novel structure, and the developed organic synthesis method has the advantages of being high in atom economy, simple in step and the like. Meanwhile, the compound also shows good anti-tumor cell proliferation activity. # imgabs0 #

This invention discloses a α The electrosynthesis method of α-aminomethyltetrazole includes: using a platinum sheet as the cathode and a carbon rod as the anode, and employing ammonium tetrabutyltetrafluoroborate as the electrolyte under constant current catalysis, a one-pot coupling of a tertiary amine, an isonitrile, and azide trimethylsilane to prepare the α-aminomethyltetrazole. α The step involving the aminomethyltetrazole derivative, followed by post-treatment and column chromatography separation of the resulting reaction mixture, yields... α - Pure aminomethyltetrazole. This invention yields it through a single reaction step. α -Aminomethyltetrazole has fewer operating steps, avoids the use of large amounts of oxidants and additives, simplifies post-processing, and makes the product easy to separate.