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pH responsive drug-loading Pickering emulsion and preparation method thereof

A responsive, emulsion technology, applied in the direction of botanical equipment and methods, applications, pesticides, etc., can solve the problems of ecological environment damage, economic waste, etc., and achieve the effect of expanding applications

Active Publication Date: 2017-10-24
HAINAN UNIVERSITY
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Problems solved by technology

However, the utilization rate of traditional pesticides is only 20%-30%, which not only causes economic waste, but also causes great damage to the ecological environment (Song et al., 2014)

Method used

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  • pH responsive drug-loading Pickering emulsion and preparation method thereof
  • pH responsive drug-loading Pickering emulsion and preparation method thereof
  • pH responsive drug-loading Pickering emulsion and preparation method thereof

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Embodiment Construction

[0034] The present invention will be further described below in combination with specific embodiments, so as to better understand the present invention.

[0035] 1. SiO2 2 Surface grafted sodium alginate (Alg-SiO 2 )

[0036] First prepare amino-terminated silica (SiO 2 -NH 2 ) particles (Guan et al., 2009). The steps are as follows: add 1.0 g of hydrophilic silica and 10 mL of APTS to 50 mL of ethanol / water (v / v=3:1) at pH=3.6, and then reflux at 80° C. for 12 h. After the mixture was centrifuged, washed three times with ethanol and water respectively, and freeze-dried to obtain amino-terminated silica particles (SiO 2 -NH 2 ). Then prepare aldehyde-terminated silica particles (SiO 2 -CHO) (Shi et al., 2009), the steps are as follows: after dispersing 0.5 g of the above particles in 30 mL (pH=8) phosphate buffer solution, add 50 mL of 25% GA. The reaction was stirred at room temperature for 12h. After the mixture was centrifuged, washed three times with ethanol and ...

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Abstract

The invention provides a pH responsive drug-loading Pickering emulsion and a preparation method thereof. The method comprises the step of preparing sodium alginate modified silicon dioxide nanoparticles which are prepared from the Ugi reaction of sodium alginate, formaldehyde, cyclohexyl isocyanide and fractal silicon dioxide, wherein the fractal silicon dioxide is prepared in the manner of utilizing layering molecular imprinting to perform covalence assembling on amino blocked silicon dioxide and aldehyde blocked silicon dioxide and repeating the imprinting process according to the requirement till reaching the required layer number of the silicon dioxide. The invention also provides a Pickering emulsion prepared from the nanometer particle. The invention can prepare a novel pH responsive Pickering emulsion in the manner of grafting sodium alginate (Alg) onto the fractal SiO2 surface through Ugi condensation reaction, can enrich the application of the triggering emulsion in a pesticide release controlling system and can widen the application of the Pickering emulsion at the aspect of pesticide delivery.

Description

technical field [0001] The invention belongs to the technical field of drug sustained release and controlled release, and in particular relates to a pH-responsive drug-loaded Pickering emulsion and a preparation method thereof. Background technique [0002] Pickering emulsions are mainly stabilized by inorganic rigid particles or polymer soft particles with good surface wettability. These adsorbed particles hinder droplet coalescence by creating strong electrostatic repulsion, large steric hindrance or high interfacial viscosity, resulting in stable emulsions for many years (Pawar et al., 2011; Tambe et al., 1993). A stable Pickering emulsion is widely used in various fields, such as food, cosmetics, coatings, pesticides, and various industrial processes such as emulsion coalescence, metal cutting and cleaning, and synthesis of nanoparticles (Fang et al., 2015; Liu et al. al., 2006; Xiao et al., 2016). However, the opposite demulsification process also has crucial applicat...

Claims

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Application Information

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IPC IPC(8): A01N25/10A01N25/04A01N53/08A01P7/04
CPCA01N25/04A01N25/10A01N53/00
Inventor 李嘉诚冯玉红林强余高波陈凯
Owner HAINAN UNIVERSITY
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