1314 results about "Condensation reaction" patented technology

The invention relates to the technical field of fine chemical engineering and flame retardant preparation, and discloses a preparation method of bromo-triazine capable of improving thermal stability, and the preparation method comprises the following steps: mixing phenol, water and dichloromethane, controlling the temperature, and carrying out oxidative bromination reaction to prepare an organic phase containing tribromophenol; then, under the action of an organic amine catalyst, carrying out condensation reaction on the organic phase, liquid caustic soda and cyanuric chloride; after the reaction, washing with water to remove impurities; and in the presence of process water, firstly controlling the temperature at 38-42 DEG C for azeotropic desolvation, then raising the temperature to 85-95 DEG C for high-temperature crystallization and crystal growing, and finally cooling, filtering and drying to obtain the bromo-triazine product. By utilizing the high selectivity of the organic amine catalyst and a two-stage azeotropic crystallization process, the side reaction is effectively reduced, the solvent wrapped in the crystal is eliminated, the prepared product is high in main content and extremely low in volatile component, the temperature can reach 370 DEG C or above when the thermal weight loss is 2%, and the thermal stability is remarkably improved.

The invention relates to the technical field of vacuum bag films for aeronautical manufacturing, and discloses an eleven-layer co-extruded film for aeronautical use and a preparation process thereof, and the preparation process specifically comprises the following steps: carrying out grafting modification treatment on polyamide acid by using a monoalkenyl diepoxy composite flexible compound through a carboxyl-epoxy ring-opening reaction to prepare alkenyl functionalized processable polyimide; the preparation method comprises the following steps: carrying out modification treatment on nylon 6 resin by using 3-mercaptopropionic acid through an amino-carboxyl condensation reaction to prepare mercapto functionalized nylon; under the hot melting condition, alkenyl functionalized processable polyimide and sulfydryl functionalized nylon are induced to be subjected to reactive compounding through a free radical initiator, PA-PI alloy master batch is prepared, the master batch serves as a functional modification component of copolymerized polyamide 6 / 66 resin, an eleven-layer co-extrusion film is prepared through an eleven-layer co-extrusion blow molding process, and the eleven-layer co-extrusion film is used as a functional modification component of the copolymerized polyamide 6 / 66 resin. The film product has excellent comprehensive performance and can be used as a high-temperature-resistant vacuum bag film for curing aviation composite materials.

The invention relates to a method for preparing a nerofloxacin chiral piperidylamine intermediate, which comprises the following steps of: carrying out condensation reaction on 5-hydroxy nicotinic acid which is simple and easy to obtain and is used as a raw material and different alcohols, screening through a series of asymmetric catalytic hydrogenation conditions to obtain optimal reaction conditions, and under the conditions, carrying out reaction on various 3, 3 '-dihydroxy nicotinic acid and 3, 3'-dihydroxy nicotinic acid to obtain the nerofloxacin chiral piperidylamine intermediate. The 2, 5-disubstituted pyridine quaternary ammonium salt is reduced into a tetrahydropyridine product, and the C5 site enantioselectivity of the product is excellent. The preparation method comprises the following steps: selecting methyl (R)-1-benzyl-5-hydroxy-1, 4, 5, 6-tetrahydropyridine-3-carboxylic acid methyl ester as a substrate, completely hydrogenating by using platinum dioxide hydrogen, and then carrying out methyl ester reduction, dehydroxylation, Mitsunobu reaction and protecting group removal to obtain a key chiral intermediate for industrial synthesis of a quinolone antibacterial drug nemonofloxacin with high enantioselectivity and high yield.

The invention relates to the technical field of microelectronics, in particular to a unimolecular memristor based on a viologen derivative and a preparation method of the unimolecular memristor. The unimolecular memristor based on the viologen derivative comprises an electrode pair and an organic functional molecule, and the organic functional molecule is selected from the viologen derivative and assembled between the electrode pair through an amide condensation reaction. According to the organic functional molecule provided by the invention, functional modification is performed on the basis of a viologen molecular structure, so that an energy barrier of reversible oxidation-reduction reaction of a viologen unit is effectively reduced, and the performance of the single-molecule memristor is remarkably improved; meanwhile, the on-off ratio of the device is also improved by one order of magnitude. According to the preparation method provided by the invention, the stability and repeatability of a monomolecular device can be ensured, and the conductive stability and durability of the molecular junction of the organic functional molecule are effectively improved. The method is simple and convenient to operate, reaction conditions are easy to control, and large-scale production of molecular devices is facilitated.

The application discloses a kind of sulfonic acid group covalent organic framework / Nafion composite material for proton conduction and preparation method and application thereof, belong to fuel cell technical field.The application first utilizes double sulfonic acid group organic aromatic amine ligand and aldehyde group ligand to construct a kind of sulfonic acid functional two-dimensional covalent organic framework material COF-(SO3H)2 by condensation reaction.COF-(SO3H)2 is compounded with Nafion polymer to prepare proton exchange membrane, and the proton exchange membrane material has excellent proton conduction, and the proton conductivity is 1.338*10 ‑1 S·cm ‑1 (80ºC).The proton exchange membrane material of the application is prepared by solvothermal process and casting method, and the preparation method is simple and easy to operate, which provides a new choice for proton conduction material in fuel cell, and expands the application value of covalent organic framework material.

The invention relates to the technical field of synthetic leather, in particular to super-soft waterborne polyurethane leather and a preparation method thereof. The leather sequentially comprises a surface layer, a middle layer and a bottom layer from top to bottom, wherein the surface layer is composed of a PCL-PEG-PCL flexible film; the bottom layer is composed of base cloth and a PCL-PEG-PCL flexible film coated on the surface of the base cloth; and the middle layer is composed of modified waterborne polyurethane prepared from PCL-PEG-PCL flexible dihydric alcohol and aliphatic linear chain diisocyanate. The preparation method comprises the following steps: synthesizing PCL-PEG-PCL dihydric alcohol, preparing each layer, and performing condensation reaction on the middle layer and the surface / bottom layer to realize chemical curing. The leather is normally super-soft, the stress strength is remarkably improved, a full-water-based system is environment-friendly, the low-temperature stability and interlayer binding strength are excellent, and the leather is suitable for the field of high-end flexible materials such as furniture veneers, automobile interiors and shoe materials.

The application belongs to the technical field of deep eutectic solvents, and particularly relates to a ternary deep eutectic solvent and preparation and application thereof. The ternary deep eutectic solvent is composed of choline chloride, 5-sulfosalicylic acid and gamma valerolactone according to a molar ratio of 1:4:(3-25). The strong hydrogen bond network structure between the green solvent system first destroys the ester bond between lignin and hemicellulose, then cuts off the beta-O-4 bond between lignin molecules, so as to separate lignin. Meanwhile, the deep eutectic solvent can improve the stability of carbon cations due to the conjugation effect between the lone pair electrons on the heteroatom oxygen and the central carbon in the molecular structure of gamma valerolactone, so as to inhibit the condensation reaction of lignin.

The invention discloses a fluorinated COF enhanced PVDF-HFP composite gel polymer electrolyte. The fluorinated COF enhanced PVDF-HFP composite gel polymer electrolyte is prepared from the following raw materials: polyvinylidene fluoride-co-hexafluoropropylene, a fluorinated covalent organic framework containing an ether oxygen bond and a carbon-carbon unsaturated double bond, bis (trifluoromethylsulfonyl) imide anion ionic liquid and fluorine-containing imide lithium salt, the fluorinated covalent organic framework containing the ether-oxygen bond and the carbon-carbon unsaturated double bond is prepared by carrying out condensation reaction on a perfluorophenylene-containing module and the ether-oxygen bond-containing aromatic module. According to the electrolyte, PVDF-HFP is used as a polymer matrix, bis (trifluoromethylsulfonyl) imidogen ionic liquid is used as a functional phase and a plasticizer, imide lithium salt is used as a lithium ion source, fluorinated COF containing ether oxygen bonds and olefinic bonds is introduced, and the electrolyte has high ionic conductivity, high lithium ion transference number, excellent mechanical property and interface stability; the method is especially suitable for a high-safety lithium metal battery system.

The present invention relates to the technical field of polymer preparation. Disclosed are a covalent organic framework material, and a preparation method therefor and a use thereof. The preparation method for the covalent organic framework material comprises the following step: subjecting an organic aldehyde and an organic amine to a condensation reaction in a deep eutectic solvent to obtain the covalent organic framework material, wherein the deep eutectic solvent is a two-component eutectic liquid composed of menthol and acetic acid. The temperature for the reaction is 25-120ºC, and the time for the reaction is 1-72 hours. The deep eutectic solvent composed of menthol and acetic acid used in the present invention has good dissolution properties for organic matters, and can also efficiently catalyze the condensation reaction between the organic amine and the organic aldehyde. The prepared covalent organic framework material exhibits high crystallinity and has good applications in the fields of adsorptive separation, heterogeneous catalysis, energy storage, etc. The present method has mild reaction conditions, simple operation, and good universality, is conducive to industrial large-scale production, and conforms to the concept of green chemistry.

The invention belongs to the technical field of epoxy resin, and particularly relates to double-dynamic-bond synergistic exchange epoxy resin as well as a preparation method and application thereof. The preparation method of the double dynamic bond synergistic exchange epoxy resin comprises the following steps: adding aromatic dialdehyde and amino-containing disulfide into a solvent for condensation reaction, and filtering and drying to obtain a double dynamic bond curing agent; the preparation method comprises the following steps: adding the double-dynamic-bond curing agent into epoxy resin, carrying out ring-opening addition reaction, carrying out gradient heating curing, and cooling to room temperature, the aromatic dialdehyde is terephthalaldehyde, isophthalaldehyde or o-phthalaldehyde, and the amino-containing disulfide is 2, 2 '-diaminodiphenyl disulfide or 4, 4'-diaminodiphenyl disulfide. The invention designs and synthesizes a double-dynamic covalent bond curing agent containing an imine bond and a disulfide bond, and is used for constructing a novel degradable and self-healing epoxy resin. The material maintains good thermal stability and insulation performance, and realizes degradation and self-healing functions at the same time.

The invention discloses a phosphorus-nitrogen synergistic flame-retardant benzoxazine / epoxy resin composite material and a preparation method thereof. Firstly, a phenolic compound and DOPO react to generate an intermediate product, and then the intermediate product, an amine compound and paraformaldehyde are subjected to a dehydration condensation reaction to generate the phosphorus-nitrogen synergistic flame retardant benzoxazine. The phosphorus-nitrogen synergistic flame-retardant benzoxazine is added into epoxy resin for thermocuring to obtain the composite material. The prepared benzoxazine flame retardant contains phosphorus and nitrogen elements, the nitrogen-based flame retardant has the advantages of low pollution, low smoke, good compatibility with EP and the like, and a quenching effect, a dilution effect and a carbon layer barrier effect can be generated in the combustion process to prevent further combustion of flames. The composite material has better flame retardant property, can effectively reduce the risk of fire hazard caused by overheating or short circuit of equipment, and ensures the safe and stable operation of energy equipment.

The invention discloses folate receptor mediated manganese ion coordination type cabazitaxel-loaded albumin nanoparticles as well as a preparation method and application thereof. Human serum albumin is covalently linked with folic acid through an amide condensation reaction to obtain a folic acid-albumin modifier with folic acid targeting; further combining with manganese ions through metal coordination to form a folic acid-albumin-manganese ion modifier with a targeting function; finally, efficient loading of cabazitaxel is achieved through a simple heating polymerization method, and the folate receptor mediated cabazitaxel-loaded albumin nanoparticles are formed. According to the nanoparticles provided by the invention, the particle size is about 140 nm, the stability is good, and the drug loading capacity and the encapsulation efficiency of cabazitaxel are high; the compound has a slow release effect, is good in in-vitro release behavior, and has important application value in the aspect of targeted delivery of drugs to tumors. Compared with other traditional nanoparticles, the nanoparticles show a remarkable anti-tumor effect.

The invention provides a preparation method of an omariglitazone intermediate, which comprises the following steps: by taking p-halogenated benzaldehyde as a raw material, carrying out aldol condensation reaction, hydrolysis, decarboxylation, reduction, ring closing and the like to obtain an intermediate as shown in a formula 9, carrying out catalytic reaction, reduction reaction, ring closing and the like to obtain an intermediate as shown in a formula 13, and finally hydrolyzing to obtain a target product omariglitazone intermediate A. According to the invention, links of precious metal use and chiral resolution (key steps influencing cost and yield) in the prior art are avoided, and a method for synthesizing a single configuration through a chemical method is adopted, so that the yield is greatly improved, and the production cost is greatly reduced; meanwhile, a synthesis route is broken through, a target product is synthesized through cheap initial materials, and post-treatment is simpler and more controllable.

The invention belongs to the technical field of high polymer chemistry and composite materials, and particularly relates to a composite proton exchange membrane and a preparation method thereof. The method comprises the following steps: adding an original multi-walled carbon nanotube into a mixed acid solution, and carrying out oxidation treatment to obtain an acidified carbon nanotube; carrying out condensation reaction on the acidified carbon nanotube, a condensing agent and sulfanilic acid in a solvent system to obtain a sulfonated carbon nanotube; dispersing the sulfonated carbon nanotubes in an acetic acid solution to form a dispersion liquid, dissolving chitosan in the acetic acid solution to form a chitosan solution, and mixing the dispersion liquid with the chitosan solution to prepare a membrane casting solution; forming a membrane from the membrane casting solution to obtain an initial composite proton exchange membrane; and placing the initial composite proton exchange membrane in a sulfuric acid solution for crosslinking treatment, washing and drying to obtain the target composite proton exchange membrane. Based on the method, the technical effect of preparing the proton exchange membrane with excellent comprehensive performance is achieved.

The invention belongs to the technical field of coating materials, and particularly relates to an ablation-resistant anti-aging coating on the surface of an aircraft and a preparation method of the ablation-resistant anti-aging coating. A silane coupling agent containing an epoxy group and vinyl and boric acid are used as raw materials, an organic silicon-boron hybrid oligomer with a Si-O-Si and Si-O-B bond stereo structure is obtained by adjusting the ratio of the silane coupling agent to the boric acid and serves as a bridge, and phenolic resin, hydrogen-containing silane and vinyl silicone rubber are combined together to form the ablation-resistant anti-aging coating. Wherein an epoxy group and a phenolic hydroxyl group are subjected to a condensation reaction, vinyl and a platinum catalyst form a compact cross-linked structure through hydrogen-containing silane, and the obtained coating has a lower ablation rate, better anti-UV weather resistance and higher flexibility, is suitable for long-time protection of the surface of an aircraft, and has a better ablation protection effect under shear airflow impact.

The invention discloses a surface low-energy silicon dioxide shell phase change microcapsule, a moisture resistance control construction method and application thereof. Firstly, core-shell structure microcapsules with octadecane as a heat energy storage core material and silicon dioxide as a protective shell layer are prepared through an interfacial polymerization method, and phase change microcapsule powder is obtained. And then, constructing an alkylated low-energy interface layer on the surface of the microcapsule shell by utilizing an organosilane hydrolysis-condensation reaction. The phase change microcapsule treated by the method can effectively inhibit a shell layer from adsorbing free moisture in a humid environment, alleviate the phenomenon of interface instability at the initial stage of cement hydration, and improve the construction fluidity and circulating energy storage durability of a cement-based material. Meanwhile, the composite can be used as functional microparticles to be applied to building outer surface coatings, and antifouling, anti-infiltration and photo-thermal regulation and control effects are achieved. The method is simple, convenient and high in adaptability, large-scale production can be achieved, and a new solution is provided for construction of building functional materials with energy conservation, energy storage and interface stability.

The invention relates to the field of silane coupling agents, and discloses a preparation method of a sulfur-containing silane coupling agent, which comprises the following steps: step 1, mixing alkali metal sulfide with sulfur, stirring, and reacting to obtain a sodium polysulfide solution; step 2, adding a pH regulator, a hydrolysis inhibitor and a phase transfer catalyst into the sodium polysulfide solution, dropwise adding 3-halogen propyl trialkoxysilane, and stirring for condensation reaction to obtain a crude product reaction solution; 3, the crude product reaction liquid is sequentially subjected to distillation, decolorization with a decolorizing agent and filtration, and the sulfur-containing silane coupling agent is prepared after the steps are completed. The crystal water contained in the raw materials is used as a reaction medium, so that additional addition of an organic solvent and pre-drying and dehydration treatment are not needed, the spontaneous combustion risk of sodium sulfide is avoided, raw material pretreatment and solvent recovery procedures are omitted, and the whole technological process is simplified, so that the operation is simple and convenient, and the cost is low. The method is suitable for large-scale industrial production.

The invention discloses a phototherapy reagent and a preparation method and application thereof. The preparation method comprises the following steps: 1-[4-(diethylamino) phenyl]-ethane-1-ketone and 4-methoxybenzaldehyde are subjected to a condensation reaction in a NaOH ethanol solution, and a product and nitromethane are subjected to addition; performing condensation and addition on the other groups of raw materials by the same method; cyclizing the two addition products with ammonium acetate, and coordinating with boron trifluoride diethyl etherate to obtain NHM; carrying out substitution reaction on the NHM and sodium nitrite to obtain NOO; and oxidizing NOO by m-chloroperoxybenzoic acid to obtain NNOO. The reagent can target a tumor hypoxia microenvironment, hypoxia monitoring is achieved, NO is released through photostimulation for tumor gas therapy, meanwhile, the secondary amplification photo-thermal therapy effect is achieved, preparation is controllable, diagnosis and treatment are integrated, and the reagent is sensitive, safe and suitable for biomedical research and clinical diagnosis.

The application discloses an alkali ion type covalent organic framework material and a preparation method and application thereof, wherein 2,4,6-tris(4-formylphenyl)-1,3,5-triazine, 1,4-diisocyanobenzene and 2-aminopyridine are used as building units, a covalent organic framework containing pyrimidine is obtained through a condensation reaction, and then a quaternary ammonium reaction and an ion exchange reaction are sequentially performed to obtain the alkali ion type covalent organic framework.The alkali ion type covalent organic framework material prepared by the application has rich alkali sites, developed pore structures and good chemical stability, exhibits good catalytic performance as a catalyst for one-pot preparation of dimethyl carbonate from CO2, an epoxide compound and methanol, and also shows good cycle stability.

This invention discloses a polyoxometalate that catalyzes the Knoevenagel reaction, its preparation method, and its applications. The chemical formula of the polyoxometalate that catalyzes the Knoevenagel reaction is: H3[K(H2O)6][K2(H2O) 10 ]2[Cu(en)2(H2O)2][Cu(en)2(Nb6O 19 Cu(en))2·24H2O, where en = ethylenediamine; the polyoxometalate crystals catalyzing the Knoevenagel reaction belong to the triclinic crystal system with space group P-1; the polyoxometalates catalyzing the Knoevenagel reaction prepared in this invention exhibit excellent heterogeneous catalytic performance in the highly efficient Knoevenagel condensation reaction, showing high yield and high stability under isothermal conditions at a 1:1 substrate ratio and over a wide substrate range. The superior catalytic ability of the polyoxometalates catalyzing the Knoevenagel reaction can be attributed to the presence of dense and effective basic sites on the surface of the heteropolycationic chain, and the increased contact frequency between the organic-inorganic hybrid catalyst and the substrate.

The invention discloses a crosslinking self-assembly hole blocking layer material containing siloxane and anchoring groups, and belongs to the field of perovskite solar cells. In the hole blocking layer material, the siloxane component triggers alcoholysis reaction in an isopropanol medium to form a silane precursor with hydroxyl; si-OH groups between adjacent molecules are subjected to a condensation reaction to form a Si-O-Si cross-linked network; meanwhile, a Si-OH group in the precursor and an ester group on the surface of a PCBM molecule are subjected to an ester exchange process, and Si-O-C covalent linkage is constructed to realize chemical anchoring of PCBM; and an anchoring functional group at the tail end of the material and the surface of a silver electrode form a strong coordination effect, so that thermally-driven silver atom migration is effectively inhibited, and performance degradation of the perovskite solar cell under a high-temperature working condition is remarkably relieved. The invention opens up a new way for improving the thermal stability of the perovskite solar cell, and effectively solves the problem of device stability caused by metal electrode ion diffusion.

The present application relates to the chemical technology field, specifically to a kind of β-naphthalenesulfonic acid sodium formaldehyde condensate and preparation method thereof, the preparation method is prepared naphthalenesulfonic acid mixture with naphthalene and sulfuric acid as raw material, β-naphthalenesulfonic acid in naphthalenesulfonic acid mixture is extracted by melt crystallization, β-naphthalenesulfonic acid is sequentially subjected to condensation reaction, neutralization reaction and purification step, and β-naphthalenesulfonic acid sodium formaldehyde condensate is obtained.The present application extracts β-naphthalenesulfonic acid from naphthalenesulfonic acid mixture by melt crystallization method, which has high purity and high yield, and avoids removing α-naphthalenesulfonic acid by hydrolysis reaction and recycling the generated naphthalene, without using lime for impurity removal, thereby avoiding the introduction of calcium and magnesium ions and other impurities.The operation steps of the present application for preparing β-naphthalenesulfonic acid sodium formaldehyde condensate are simpler than traditional methods, and the product quality and economy of β-naphthalenesulfonic acid sodium formaldehyde condensate are improved.

The invention provides a preparation method of high-conductivity composite graphene, conductive ink and application thereof, and the preparation method comprises the following steps: dispersing graphene into a solvent to obtain a graphene dispersion liquid; adding a silane coupling agent with an amino group into the graphene dispersion liquid, and reacting to obtain aminated graphene; and adding a first dispersing agent into the aminated graphene, adding silver powder after uniform dispersion, and grinding to form an Ag-N coordinate bond between the silver powder and the aminated graphene, thereby obtaining the high-conductivity composite graphene. In the preparation method of the high-conductivity composite graphene provided by the invention, a silane coupling agent with an amino group is added into a graphene dispersion liquid, amination modification is completed through a condensation reaction with a hydroxyl group on the surface of the graphene, silver powder and the amino group of the graphene form an Ag-N coordinate bond, so that silver particles are completely coated with the graphene, a continuous C-Ag-C conductive network is constructed, and the high-conductivity composite graphene is obtained. According to the network, path breakpoints are reduced, interface contact resistance is reduced, charge transmission efficiency is improved, conductivity reduction after graphene compounding is effectively inhibited, and high conductivity and high heat resistance are achieved.

The application discloses a pinacine alkyl tetrahydrocarbazole fluorescent probe capable of detecting cell lysosome polarity and a preparation method and application thereof. 9-(3-(dimethylamino)propyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-2,4-bridged methylene carbazole-6-formaldehyde is used as raw material, and condensation reaction is carried out with 1,3-indan dione to obtain compound 2-(2-(9-(3-(dimethylamino)propyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-2,4-bridged methylene carbazole-6-yl)vinyl)-1-indene-1,3(2H)-dione (TC-AP-ID), and the probe can specifically detect the polarity of cell lysosomes. In a mixed system of 1,4-dioxane and water, with the increase of the polarity of the system, the fluorescence color of the probe gradually changes from orange to red, and the fluorescence intensity significantly decreases. The probe has the advantages of simple synthesis, good selectivity, high sensitivity, good biocompatibility, low toxicity and the like, can be applied to targeted detection of the polarity of cell lysosomes, and has a good application prospect.

A method for preparing methyl silicone resin for high-temperature mica boards includes: (1) Solution A is a mixture of methyltrimethoxysilane, dimethyldimethoxysilane, and epoxysilane coupling agent, which account for 87%-95%, 3%-7%, and 2%-6% of the total amount of A, respectively; (2) Adding 0.5-1.0 times the amount of benzene solvent, 0.2-0.3 times the amount of isopropanol, and adding 0.5%-1% of the total amount of A acidic catalyst to obtain solution B; (3) Heating B to 70℃-80℃, and uniformly adding deionized water, and adding... The time is controlled at 2-3 hours. After the addition is completed, continue stirring for half an hour to obtain solution C. The amount of deionized water is 40%-50% of the total amount of A. (4) Transfer C to a separatory funnel and let it stand to separate into layers. The lower layer of methanol solution is purified by distillation, and the upper layer of silanol solution is washed with water until neutral to obtain solution D. (5) Heat D and reflux for condensation reaction. Maintain the temperature at 130℃-140℃ for half an hour, then cool to room temperature and add benzene solvent to form a 50%-60% concentration of methyl silicone resin for high-temperature mica boards. The benzene solvent content is 40%-50%. It is environmentally friendly, has a simple process, excellent bending resistance, and good moisture resistance.

The invention discloses a preparation method of 3-quinuclidinone hydrochloride, which comprises the following steps: carrying out temperature control reaction on 4-picolinic acid and chloroacetic acid under alkaline water conditions to obtain an aqueous solution of a compound a, and directly entering the next reaction without post-treatment after the reaction is finished; adding a reducing agent alkaline water system into the aqueous solution of the compound a, controlling the temperature to react, controlling the temperature to adjust the pH value to 5-5.5 after the reaction is finished, extracting with n-butyl alcohol, and drying to obtain an n-butyl alcohol solution of a compound b, and directly entering the next reaction step; wherein the reducing agent is one of sodium borohydride and potassium borohydride; dropwise adding thionyl chloride into an n-butyl alcohol solution of the compound b, controlling the temperature to react after dropwise adding is ended, and concentrating to remove the solvent and unreacted thionyl chloride after the reaction is ended, so as to obtain a compound c; carrying out Dieckmann condensation reaction on the compound c at controlled temperature under the condition of organic alkali by using toluene as a solvent, carrying out hydrochloric acid quenching reaction after the reaction is finished, and directly carrying out next-step reaction after extracting and removing impurities from a water phase containing a hydrochloride solution of a compound d by using toluene; and carrying out a decarboxylation reaction on the compound d in a hydrochloric acid aqueous solution at controlled temperature, after the reaction is finished, adjusting the pH value to 10-13, extracting, and salifying to obtain a target compound TM, namely 3-quinuclidinone hydrochloride. The preparation method of 3-quinuclidinone hydrochloride provided by the invention has the advantages of economical and easily available raw materials, mild reaction conditions, efficient reaction, simple operation and low cost, and is suitable for industrial application.

This invention relates to a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative, its preparation method, and its application. A trifluoromethyl-substituted pyrene-phenylacetonitrile derivative has the structural formula: [formula omitted]. The preparation method involves dissolving 1-pyrene formaldehyde, the corresponding trifluoromethylphenylacetonitrile, and an alkaline catalyst in an organic solvent, and carrying out a Knoevenagel condensation reaction under heating conditions. The reaction product is then post-treated to obtain the pyrene-phenylacetonitrile derivative. The application of a trifluoromethyl-substituted pyrene-phenylacetonitrile derivative in electrical storage devices is also discussed. This invention achieves precise control of storage performance by introducing trifluoromethyl groups at different positions on the benzene ring of the pyrene-phenylacetonitrile backbone, providing a novel design approach for developing new multi-level electrical storage materials. The synthesis route is concise and has broad application prospects in the field of high-density non-volatile memory.

The present application relates to the technical field of alcohol aldehyde condensation reaction, and discloses an alcohol aldehyde condensation reaction method.The alcohol aldehyde condensation reaction method is carried out in an alcohol aldehyde condensation reaction device, the alcohol aldehyde condensation reaction device comprises a micro-channel alcohol aldehyde condensation reactor and an alcohol aldehyde condensation tube reactor which are connected in series; in the presence of an alkali catalyst, a reaction raw material n-butyl aldehyde is subjected to a first alcohol aldehyde condensation reaction in the micro-channel alcohol aldehyde condensation reactor to obtain a first alcohol aldehyde condensation reaction product; and the first alcohol aldehyde condensation reaction product is subjected to a second alcohol aldehyde condensation reaction in the alcohol aldehyde condensation tube reactor.The method uses a micro-channel alcohol aldehyde condensation reactor and an alcohol aldehyde condensation tube reactor to replace a full-mixing kettle reactor in the prior art to carry out alcohol aldehyde condensation reaction, so that the yield of a by-product heavy carbon alcohol can be significantly reduced, and the yield of a target product can be improved.

The application relates to the technical field of fine chemicals, and discloses a method for preparing secondary alcohol by catalyzing alpha-olefin hydration. The method comprises the following steps: under the catalysis of a catalyst, performing an aldehyde amine condensation reaction on 1,3,5-tri-(p-formylphenyl) benzene and o-sulfonic acid p-phenylenediamine in a first organic solvent in an air-isolated condition, then sequentially performing washing and drying on the obtained reaction product to obtain a COF-HSO3 catalyst, and then under the catalysis of the COF-HSO3 catalyst, performing a hydration reaction on alpha-olefin in a second organic solvent and water. The method for preparing secondary alcohol by catalyzing alpha-olefin hydration has high alpha-olefin conversion rate and secondary alcohol yield.

This invention provides a method for preparing and applying a highly insecticidal diamide compound, relating to the chemical and pesticide fields. The method includes: reacting 2-fluoro-3-nitrobenzoic acid with thionyl chloride (a chlorinating agent) and dimethylformamide (a catalyst) to obtain compound A; condensing compound A with 2-trifluoromethyl-4-heptafluoroisopropyl-6-bromoaniline amide to obtain compound B; reducing compound B to obtain compound C; and, during the reaction under a hydrogen atmosphere, determining the reaction temperature and hydrogen flow rate in each hydrogenation reaction zone based on the concentration of compound B; reacting compound C with paraformaldehyde to obtain compound D; chlorinating 3-chloro-4-fluorobenzoic acid with thionyl chloride (a chlorinating agent) and dimethylformamide (a catalyst) to obtain compound E; and amide condensing compound E with compound D to obtain the novel diamide compound of this invention. The diamide compound of this invention exhibits excellent insecticidal effects when used in pesticide compositions.