2416 results about "Condensation reaction" patented technology

The invention discloses a high-viscosity activated rubber powder grafted functionalized block copolymer composite modifier and preparation thereof, composite modified asphalt and preparation and application thereof, and belongs to the technical field of modified asphalt. The composite modifier disclosed by the invention is formed by grafting catechol / polyamine modified aminated rubber powder and an epoxidized block copolymer. A catechol / polyamine group and an amino group are subjected to a condensation reaction to jointly modify the surface of the rubber powder, so that the surface of the rubber powder has rich functional groups and active sites, the rubber powder and an epoxidized block copolymer are subjected to a chemical crosslinking reaction in the later period, and the effect of enhancing the full performance of asphalt by the composite modifier is achieved; the problems that the composite modifier and the modified asphalt are prone to agglomeration, poor in compatibility and the like are solved. A self-healing mixture prepared from the composite modified asphalt and a self-healing material together has synergistic effects of the composite modified asphalt and the self-healing material, so that the pavement performance and the use quality are effectively improved, the service life of a road is prolonged, the energy loss is reduced, and the composite modified asphalt has application value in the field of roads.

A method of preparing an alkyl phosphate compound based on a micro-reaction system. The micro-reaction system includes a feed pump, a first micro-mixer, a second micro-mixer, a first micro-channel reactor, a second micro-channel reactor and a back-pressure device, where the first micro-mixer, the second micro-mixer, the first micro-channel reactor, the second micro-channel reactor and the back-pressure device are sequentially connected. The method includes the following steps. An alkylamine compound and an acid-binding agent are simultaneously fed to a first micro-mixer for mixing and then to the first micro-channel reactor for pre-reaction to obtain a pre-reaction solution. The pre-reaction solution and a phosphate or phosphite are simultaneously fed to the second micro-mixer for mixing to obtain a first reaction mixture. The first reaction mixture is fed to the second micro-channel reactor to carry out a condensation reaction under a back pressure condition and is concentrated to obtain the final product.

The invention discloses a porous carbon material as well as a preparation method and application thereof, and the porous carbon material is prepared by the following steps: by taking a silicon dioxide mesoporous hollow sphere as a hard template through a hard template method, carrying out condensation reaction on phenol and formaldehyde in the hollow part of the silicon dioxide mesoporous hollow sphere to form phenolic resin; and curing, carrying out carbon activation treatment and etching to obtain the spherical phenolic resin porous carbon material. The porous carbon material prepared by the preparation method disclosed by the invention has a relatively high specific surface area and a relatively uniform pore structure, and the cycle performance of a secondary battery can be improved when the porous carbon material disclosed by the invention is used for preparing a negative pole piece and assembling the negative pole piece into the secondary battery.

The invention discloses a preparation method of a GLP-1R agonist Orforglipron, which comprises the following reaction steps: carrying out four-step reaction on an oxopiperidine compound (1) and (4-fluoro-3, 5-dimethylphenyl) hydrazine (2) to obtain a compound 8, and carrying out seven-step reaction on 5-bromo-indolecarboxylic acid (9) to obtain a compound 17. Then, the compound 8 and a compound 17 are subjected to an acid amine condensation reaction, and Orforglipron (LY3502970) is obtained. The preparation method is relatively low in cost, easy to operate, relatively short in synthetic route and suitable for industrial production and application, and the total yield can reach 32%.

The invention discloses a modified organic silicon resin, a high-temperature-resistant coating and a preparation method thereof, the modified organic silicon resin is prepared by hydrolyzing at least two different siloxane monomers and then carrying out condensation reaction on the hydrolyzed siloxane monomers and at least one boric acid monomer, and the main chain of the organic silicon resin is of a heteroatom doped structure formed by a Si-O bond, a B-O bond and a B-O-Si bond; at 200-250 DEG C, the modified organic-inorganic high-temperature-resistant composite material is subjected to a self-crosslinking reaction. The high-temperature-resistant coating overcomes the defect that the high-temperature-resistant coating in the prior art cannot meet the high-temperature test, and avoids the defects that organic and inorganic high-temperature-resistant coatings crack, the impact resistance and hardness are not matched, the water resistance is poor, and the wear resistance is poor.

The invention discloses a glue solution for a copper-clad plate and a preparation method of the glue solution, and relates to the technical field of copper-clad plates. According to the prepared glue solution for the copper-clad plate, the composite epoxy resin, the curing agent, the accelerant, the solvent, the flexibilizer and the inorganic filler, the composite epoxy resin comprises bisphenol A epoxy resin, epoxy phenyl polysiloxane, itaconic acid polyaryletherketone and hydroxyl-terminated fluorine-containing vinyl polysiloxane, so that the interface bonding force with the copper plate is enhanced; the dielectric constant and the dielectric loss are effectively reduced, the peel strength and the toughness of the material are also remarkably improved, and the toughening agent is modified polyether sulfone microspheres; the modified polyethersulfone microspheres are prepared by coating polyethersulfone microspheres with hexamethylenediamine tetrapropionamide diamine, the hexamethylenediamine tetrapropionamide diamine is prepared by carrying out acylation condensation reaction on hexamethylenediamine tetramethyl propionate and ethylenediamine, and the polyethersulfone microspheres are prepared by carrying out electrostatic spinning on a spinning solution of polyethersulfone and vinylpyridine, so that the peel strength of the glue solution is remarkably improved.

The invention belongs to the technical field of environmental protection, and provides a preparation method of an imine-modified functionalized mesoporous magnetic silicon dioxide nano material. The method comprises the following steps: synthesizing Fe3O4 magnetic nanoparticles in a Fe < 2 + > / Fe < 3 + > alkaline hydrolysis system through a coprecipitation method; then coating the magnetic nanoparticles with an amorphous silicon dioxide layer by taking TEOS (tetraethoxysilane) as a silicon source by adopting a sol-gel method, so as to prepare magnetic silicon coated nanoparticles; the prepared nano-particles are subjected to secondary silicon coating guided by a cetyl trimethyl ammonium bromide (CTAB) mesoporous template agent, and mesoporous magnetic silicon nano-particles are formed after calcination; and finally, carrying out surface amination modification on the mesoporous magnetic silicon nano-particles by utilizing an amino silane coupling agent, and then carrying out condensation reaction on the mesoporous magnetic silicon nano-particles and various aldehyde derivatives to construct imine bonds, so as to obtain the imine-modified functionalized mesoporous magnetic silicon dioxide nano-material. The imine-modified functionalized mesoporous magnetic silicon dioxide nano-material formed by the invention has the characteristics of efficient adsorption, rapid magnetic recovery and excellent environmental stability, and can effectively remove polystyrene micro-plastics and organic pollutants in a water body.

The invention discloses a low-temperature self-repairing polysiloxane material based on coordinate bonds and a preparation method and application thereof, and belongs to the field of novel materials.The low-temperature self-repairing polysiloxane material is prepared through the steps that amino of bis (3-aminopropyl)-terminated poly (dimethyl siloxane) and aldehyde group of an aldehyde group small molecule compound are subjected to a Schiff base condensation reaction, and a prepolymer is obtained; and adding metal ions into the prepolymer to carry out a coordination reaction to form a reversible metal coordination bond, and removing the solvent after the reaction is finished to obtain the low-temperature self-repairing polysiloxane material based on the coordination bond. The formed three-dimensional structure contains a large number of reversible metal coordination bonds, so that the rigidity and the mechanical strength of the material are enhanced, and meanwhile, the good self-repairing performance and the machinable recoverability of the material are ensured. The coordination bond-containing self-repairing polysiloxane material can be applied to the fields of adhesives, sealants, rapid self-repairing coatings, composite materials and the like.

The invention discloses a corrosion-resistant polysilsesquioxane modified polyurethane emulsion and a preparation method thereof, and belongs to the technical field of emulsions.The preparation method comprises the steps that gamma-aminopropyltriethoxysilane, namely APTES, is subjected to hydrolytic condensation under the catalysis of tetraethylammonium hydroxide, and POSS is prepared; the preparation method comprises the following steps: carrying out hydrolytic condensation reaction on APTES, synchronously adding phenyltrimethoxysilane in the hydrolytic condensation reaction, forming phenyl-amino difunctional POSS (Polyhedral Oligomeric Silsesquioxane) according to a molar ratio of phenyltrimethoxysilane to APTES of 1: 4, and grafting POSS and graphene oxide GO in dimethyl sulfoxide through amidation reaction to prepare a POSS / GO composite material; dispersing POSS / GO / Zn in the polyurethane prepolymer, adding a curing agent and a solvent, and stirring to form a homogeneous emulsion; through phenyl trapezoid polysilsesquioxane modification and dynamic reversible self-repairing network design, the wear resistance of the coating is improved, microcracks can be closed at the temperature of 60 DEG C, and the maintenance requirement is reduced; laser micro-nano structured base material treatment is combined, the adhesive force is increased to be larger than or equal to 20 MPa, and meanwhile a gamma-butyrolactone low-VOC solvent is adopted.

The invention relates to the field of artificial leather, and discloses a high-dispersion halogen-free flame retardant polyether polyol composite material and a preparation method thereof, and the high-dispersion halogen-free flame retardant polyether polyol composite material comprises the following components by mass: 60-75 parts of a polyether polyol matrix; 20 to 30 parts of a core-shell synergistic flame retardant; 3 to 5 parts of a hyperbranched polysiloxane dispersant; 2-5 parts of a nano zinc borate synergist; 0.5 to 1 part of an anti-dripping agent; the preparation method comprises the following steps: preparing a phosphorus-nitrogen core-shell flame retardant; premixing with polyether polyol, and performing dynamic condensation to form a bonding interface; carrying out ultrasonic-shearing synergistic dispersion on the nano material; and finally, carrying out underwater pelletizing to obtain the high-dispersion halogen-free composite material. According to the invention, through cooperation of core-shell flame-retardant structure design and a dynamic process, and combination of hyperbranched dispersant multi-point anchoring and ultrasonic-shear energy field dispersion technologies, efficient dispersion of a flame retardant and a nano material is realized; the interfacial condensation reaction is accurately controlled through a low-oxygen environment, and the flame retardant efficiency and thermal stability of the material are improved.

The invention relates to the field of pinacolone condensation reaction processing, in particular to a pinacolone condensation reaction exhaust device capable of preventing liquid accumulation and an exhaust method, the pinacolone condensation reaction exhaust device comprises a pinacolone reaction kettle, and a feeding pipe is connected above the pinacolone reaction kettle in a penetrating manner. Waste gas makes contact with all the sets of curved condensation pipes which are annularly distributed and installed, the conveying and contact efficiency of the waste gas can be improved through a turbofan, when the waste gas enters the exhaust barrel, the waste gas can make full contact with a conical condensation ring and a conical condensation plate which are specially arranged, and therefore secondary condensation is conducted on the waste gas, and the waste gas can be recycled. The liquid component in the waste gas can be thoroughly condensed and formed, finally falls down, is collected into a space formed by the flange butt joint pipe and the conical frame, and is discharged out of the water inlet pipe I, so that the liquid component in the waste gas can be effectively separated; therefore, the pipeline can be effectively protected and the pipeline is prevented from being blocked by accumulated liquid in the exhaust gas emission process, and meanwhile, the exhaust gas treatment efficiency and quality can be improved.

The present invention discloses a preparation method of yellow azoxy and azo stilbene dyes. Using 4-nitrotoluene-2-sulfonic acid as a raw material and water as a reaction solvent, in the presence of choline hydroxide, dye yellow 11 is obtained through a condensation reaction. The molecular structure of choline hydroxide contains a quaternary ammonium salt group and a hydroxyl group. The hydroxyl group provides additional hydrophilicity, which helps to improve the solubility and dispersibility of the dye in an aqueous medium and enhance the affinity between the dye and the fiber. Choline hydroxide can effectively provide the alkaline environment required for the reaction, promote the synthesis reaction of the dye, and better control the selectivity and yield of the reaction. Since the choline hydroxide molecule contains a hydroxyl group, it can form hydrogen bonds with the sulfonic acid groups in the dye molecule, enhance the stability between dye molecules, and improve the light fastness and acid and alkali resistance of the dye. Using choline hydroxide not only optimizes the reaction conditions, improves the purity and yield of the dye, but also significantly improves the performance of dye yellow 11.

The invention relates to the field of oil storage microcapsules, and discloses a porous covalent organic framework oil storage microcapsule as well as a preparation method and application thereof. Under the catalysis of p-toluenesulfonic acid, 4, 4 ', 4' '-(1, 3, 5,-triazine-2, 4, 6-triyl) triphenylamine and trialdehyde phloroglucinol monomers are promoted to be subjected to condensation reaction in the repeated oscillation process, a product is purified to prepare a 4, 4', 4 ''-(1, 3, 5,-triazine-2, 4, 6-triyl) triphenylamine covalent organic framework, and by means of a periodic pore structure of the covalent organic framework, the covalent organic framework can be used for preparing the covalent organic framework. And the lubricating oil is adsorbed and stored and can be controllably separated out to provide lubrication during working, so that a high-performance self-lubricating effect can be realized. In addition, covalent organic frameworks are used as hard particles to be doped into a polymer matrix to modify the polymer matrix, so that the wear resistance of the polymer matrix can be greatly enhanced, and the performance of the self-lubricating bearing material is improved.

The invention discloses an integrated reaction process for preparing potassium fluoborate through efficient conversion of fluosilicic acid, and relates to the technical field of inorganic fluorine chemical industry, and the potassium fluoborate is prepared through the technologies of complexing metal impurities through EDTA disodium, catalyzing condensation reaction through Fe-TiO2, carrying out K2CO3 / nano gamma-Al2O3 composite desilicication, deeply removing sodium through ion exchange and carrying out mother liquor closed-loop circulation. The problems of serious sodium pollution, low reaction efficiency and resource waste in the traditional process are solved. The composite desiliconization agent improves the desiliconization rate to 96%, the reaction time is shortened by 40% through nanometer catalysis, the mother liquor recycling rate is 80%, and the silicon slag is converted into high-added-value nanometer white carbon black. The product purity is greater than or equal to 99.5%, the sodium residue is less than or equal to 0.003%, and the method is suitable for industrial production of electronic-grade potassium fluoborate.

The invention discloses a halogen-free flame-retardant benzoxazine-epoxy / aramid fiber composite material and a preparation method thereof, and belongs to the technical field of polymer composite materials. The composite material is obtained by heating and curing main chain type phosphorus-containing benzoxazine, epoxy resin and aramid fiber according to the mass fraction ratio of (1%-50%): (40%-70%): (30%-70%); the main chain type phosphorus-containing benzoxazine is prepared by carrying out Mannich condensation reaction on phosphorus-containing diamine, bisphenol and paraformaldehyde according to the molar ratio of 1: 1: (4.1-4.4). According to the prepared composite material, main chain type phosphorus-containing benzoxazine modified epoxy resin serves as a matrix, the matrix and aramid fibers are subjected to heating curing to prepare the composite material, benzoxazine is crosslinked with the aramid fibers and the epoxy resin when subjected to ring opening polymerization, the interface bonding performance between the aramid fibers and the epoxy resin can be remarkably improved, and the composite material can be used for preparing the aramid fibers and the epoxy resin. The mechanical property of the composite material can be effectively improved; meanwhile, benzoxazine contains phosphorus, so that the flame retardant property of the composite material can be improved, and the application field of the aramid fiber composite material is expanded.

The invention relates to a preparation method of a high-lithium-affinity vinylene covalent organic framework material serving as a lithium metal negative electrode interface protective layer. The method comprises the following steps: firstly, by utilizing a simple hydrothermal synthesis method, taking 1, 3, 5-trimethyl-2, 4, 6-triazine (TMT) and 2, 2-bipyridine-5, 5-diformaldehyde (BPY) as monomers, and carrying out Aldol condensation reaction to synthesize a covalent organic framework material connected by a vinylene bond, which is named as viCOF-bpy; the electrochemical performance of the material is verified by modifying the surface of a copper pole piece with the viCOF-bpy material and then assembling a battery. The lithium-loving group on the material skeleton can promote the migration of lithium ions, and the vinylidene has very strong chemical stability, so that the electrochemical performance of the lithium metal battery can be effectively improved.

The present invention discloses a method for preparing a linker-drug conjugate and its intermediates. Specifically, a method for preparing compound LE14 is provided, which comprises subjecting an intermediate compound of formula II to an amide condensation reaction with a compound of formula III or its mesylate in the presence of a condensing agent, a base, and a solvent to obtain a compound of formula I. This method can produce a high-purity intermediate II, which is directly condensed with isotecan mesylate to obtain compound I, and then subjected to subsequent reactions to obtain the final product LE14. The preparation method of the present invention has one or more of the following advantages: using intermediate II as the starting material for the production process reduces process steps, facilitates product quality control, significantly reduces impurities in the final product, and improves purity. Furthermore, using the more economical isotecan for the condensation reaction significantly reduces production costs, making it more suitable for industrial production.

The invention relates to the technical field of semiconductors, and discloses a preparation method of a heat-conducting polyurethane polishing pad, which comprises the following steps: coupling a silane coupling agent with a hydroxylated inorganic heat-conducting material, and carrying out condensation reaction on silanol groups in the silane coupling agent and hydroxyl groups in the hydroxylated inorganic heat-conducting material to form Si-O-Si covalent bonds; bridging a hydroxylated inorganic heat-conducting material at one end of a silane coupling agent to obtain an intermediate; the intermediate is an inorganic heat-conducting material modified by a silane coupling agent; mixing the polyurethane prepolymer with the intermediate to form a mixed prepolymer, and curing the mixed prepolymer at a first temperature to obtain heat-conducting polyurethane; or curing the polyurethane prepolymer to obtain polyurethane, carrying out melt blending on the polyurethane and the intermediate at a second temperature, and curing at a first temperature to obtain heat-conducting polyurethane, in the heat-conducting polyurethane, polyurethane is bridged at the other end of the silane coupling agent. Compared with the prior art, the heat transfer and heat conduction performance of the polishing pad is effectively improved.

The invention relates to the technical field of coating materials, and discloses a pure titanium micro-arc oxidation coating for a vacuum cup and a preparation method thereof.The preparation method comprises the following steps that surface pretreatment is conducted, specifically, a pure titanium vacuum cup inner container workpiece is sequentially subjected to degreasing, acid pickling and ultrasonic cleaning; preparing an electrolyte, namely adding 15-25 parts by weight of a silicon-containing compound, 5-12 parts by weight of metal salt, 3-8 parts by weight of an antibacterial agent and 1-5 parts by weight of a stabilizer into deionized water, and controlling the pH value to be 8.5-10.5; and performing micro-arc oxidation treatment. According to the invention, a silane compound in the micro-arc oxidation electrolyte contains a high-activity silanol group which is subjected to condensation reaction with titanium hydroxyl on the surface of a pure titanium substrate under the action of an electric field to form stable covalent bonding, so that the bonding strength of the coating and the substrate is enhanced; metal ions generated by metal salt electrolysis are co-deposited with titanium ions through plasma discharge, a composite oxide structure is constructed, and micro defects on the surface of a titanium substrate are sealed.

The invention provides an anti-sticking slag coating based on regenerated alumina powder, and relates to the technical field of coatings, the anti-sticking slag coating comprises regenerated alumina powder, an adhesive, a dispersing agent, a thickening agent, a rheological agent and other assistants.The regenerated alumina powder is adopted as a main component, aluminum oxide is used for promoting hydrolysis-condensation reaction of an adhesive precursor, and the anti-sticking slag coating is prepared. An inorganic gel network is formed, normal-temperature curing is achieved, the adhesion situation is remarkably reduced after molten steel and molten aluminum pouring faces are sprayed, and the product performance is excellent; a dispersing agent, a thickening agent and a rheological agent are used for synergistically finishing rheological property regulation and control of the anti-sticking slag coating, a'shear thinning 'flow pattern is constructed, the viscosity is suddenly reduced during spraying so as to realize atomization, the viscosity is increased after spraying, and the anti-sticking slag coating is particularly suitable for uniform film forming of furnace bodies in complex shapes; in the formula, the regenerated aluminum oxide and the selected auxiliaries such as the adhesive, the thickening agent and the rheological agent do not contain volatile organic compounds such as benzene and formaldehyde, the product is free of pungent smell in the spraying process, and the environment-friendly performance of the product is particularly good.

The invention discloses a high-molecular-weight phosphamide aggregate flame retardant and a preparation method thereof.The method comprises the steps that phosphoryl dichloride compounds and piperazine anhydrous serve as raw materials, an amino-terminated phosphamide polymer is synthesized through a condensation reaction, and the phosphamide polymer flame retardant is obtained. The high-molecular-weight phosphamide aggregate flame retardant is obtained through a ring-opening reaction of amino-terminated groups and epoxy groups between the high-molecular-weight phosphamide aggregate flame retardant and triglycidyl isocyanurate. Compared with an existing small-molecule flame retardant, the flame retardant is higher in thermal stability, better in compatibility with a high polymer material matrix, not prone to migration and capable of achieving synergistic flame retardance due to the fact that the flame retardant contains phosphorus and nitrogen structural units at the same time, and when the prepared flame retardant is added into TPU, PC, EP, PET and other transparent matrixes, the flame retardance is improved. The flame retardant property of the transparent base material can be improved, and meanwhile, good mechanical property and high light transmittance can be kept. In addition, the preparation method disclosed by the invention is simple and easy to control, high in yield, wide in source of required raw materials, easy for industrial production and wide in industrial application prospect.

The invention relates to the technical field of cementing materials, in particular to an environment-friendly high-performance cementing material based on fly ash and slag and a preparation method of the environment-friendly high-performance cementing material. The environment-friendly high-performance cementing material comprises the following raw materials in parts by weight: 80-100 parts of fly ash, 16-20 parts of slag, 10-14 parts of desulfurized gypsum, 4-6 parts of gasified slag and 0.6-0.8 part of a composite activator, according to the invention, the gasified slag is pretreated to form a rich pore structure, the specific surface area of the gasified slag is increased, then the desulfurized gypsum and the 3-aminopropyltriethoxysilane are combined to carry out hydrolytic condensation reaction, and through the bridging effect of the silane coupling agent, the specific surface area of the gasified slag is increased; the interface bonding force between the desulfurized gypsum and other cementing materials is remarkably enhanced, so that the strength performance of the cementing material is improved, other natural materials are replaced with solid waste, the production cost of the cementing material can be effectively reduced, meanwhile, accumulation of waste is effectively reduced, cyclic utilization of resources is achieved, and natural resources are protected.

The invention discloses a strong-hydrophobicity chromatographic stationary phase modified by a covalent triazine skeleton containing an octyl chain as well as a preparation method and application of the strong-hydrophobicity chromatographic stationary phase. Activated silica gel is modified by utilizing a silane coupling agent, so that gamma-glycidyl ether oxypropyl trimethoxy is introduced into the surface of the silica gel; and performing in-situ growth of a covalent triazine skeleton layer containing an octyl chain through a Schiff base condensation reaction to prepare the strong-hydrophobicity chromatographic stationary phase. A covalent triazine skeleton containing a hydrophobic octyl chain in the structure is used for modifying the surface of silica gel, and a bonding phase contains a triazine ring, a benzene ring, an octyl chain and an amino group. According to the stationary phase, a hydrophobic long octyl chain is introduced into a bonding unit of CTF, so that the structure, morphology and performance of the CTF are changed, a'flower-on-sphere 'morphology is formed, and the stationary phase has a rigid porous structure, adjustable hydrophilicity / hydrophobicity, a rich pi electron system, strong hydrophobicity and good separation selectivity for non-polar compounds, and can be widely applied to separation of various samples.

The invention relates to the technical field of fine chemical engineering and flame retardant preparation, and discloses a preparation method of bromo-triazine capable of improving thermal stability, and the preparation method comprises the following steps: mixing phenol, water and dichloromethane, controlling the temperature, and carrying out oxidative bromination reaction to prepare an organic phase containing tribromophenol; then, under the action of an organic amine catalyst, carrying out condensation reaction on the organic phase, liquid caustic soda and cyanuric chloride; after the reaction, washing with water to remove impurities; and in the presence of process water, firstly controlling the temperature at 38-42 DEG C for azeotropic desolvation, then raising the temperature to 85-95 DEG C for high-temperature crystallization and crystal growing, and finally cooling, filtering and drying to obtain the bromo-triazine product. By utilizing the high selectivity of the organic amine catalyst and a two-stage azeotropic crystallization process, the side reaction is effectively reduced, the solvent wrapped in the crystal is eliminated, the prepared product is high in main content and extremely low in volatile component, the temperature can reach 370 DEG C or above when the thermal weight loss is 2%, and the thermal stability is remarkably improved.

The invention relates to the technical field of new material application, and discloses a magnetic bead material for enriching a sulfydryl peptide fragment and a preparation method thereof.The magnetic bead material prepared from micron carboxyl magnetic beads, dodecane dicarboxylic acid dihydrazide and SPSP has a long chemical reaction connecting arm, so that a reaction group has the better freedom degree, the reaction with sulfydryl is better facilitated, and the magnetic bead material can be used for enriching the sulfydryl peptide fragment. The enrichment efficiency is relatively high. When the magnetic bead material is prepared, micron carboxyl magnetic beads and dodecane dicarboxylic acid dihydrazide are based on hydrazine group and carboxyl condensation, the condensation reaction is more selective and more stable, the reaction is carried out under a milder condition, the reaction product is stable, and the reaction efficiency is higher at a lower reaction temperature. Dodecane dicarboxylic acid dihydrazide and SPSP are based on a reaction of N-succinimide and hydrazine, N-succinimide has high specificity to amino-containing molecules, side reactions are reduced, the reaction is generally carried out at room temperature, strong acid and alkali conditions are not needed, and protection of other sensitive groups is facilitated.

The invention discloses a chiral amine reagent and a preparation method thereof as well as a method for analyzing and splitting a chiral drug, the chiral amine reagent is APMA # imgabs0 # or d5-APMA # imgabs1 #, and the configuration of a carbon atom connected with an amino group on a piperidine ring in the structural formula is an S configuration. The APMA and d5-APMA provided by the invention can be used for analysis and detection of chiral drugs, 3-aminocyclohexyl-phenyl methane ketone (APMA) and the d5-APMA in a stable isotope form thereof are independently or jointly used as a pair of isotope labeling reagents and are subjected to condensation reaction with the chiral drugs to obtain derivatives, enantiomers of the chiral drugs can be effectively split, and the chiral drugs can be analyzed and detected. And an easy-to-ionize group is introduced, so that the mass spectrum response in an ESI positive ion mode is greatly improved.

The invention relates to the technical field of vacuum bag films for aeronautical manufacturing, and discloses an eleven-layer co-extruded film for aeronautical use and a preparation process thereof, and the preparation process specifically comprises the following steps: carrying out grafting modification treatment on polyamide acid by using a monoalkenyl diepoxy composite flexible compound through a carboxyl-epoxy ring-opening reaction to prepare alkenyl functionalized processable polyimide; the preparation method comprises the following steps: carrying out modification treatment on nylon 6 resin by using 3-mercaptopropionic acid through an amino-carboxyl condensation reaction to prepare mercapto functionalized nylon; under the hot melting condition, alkenyl functionalized processable polyimide and sulfydryl functionalized nylon are induced to be subjected to reactive compounding through a free radical initiator, PA-PI alloy master batch is prepared, the master batch serves as a functional modification component of copolymerized polyamide 6 / 66 resin, an eleven-layer co-extrusion film is prepared through an eleven-layer co-extrusion blow molding process, and the eleven-layer co-extrusion film is used as a functional modification component of the copolymerized polyamide 6 / 66 resin. The film product has excellent comprehensive performance and can be used as a high-temperature-resistant vacuum bag film for curing aviation composite materials.

The invention relates to the technical field of resin for printing ink, and discloses alcohol-soluble polyamide resin for printing ink and a preparation method and application thereof.The alcohol-soluble polyamide resin is prepared from, by weight, 78-83 parts of vegetable oil dimer acid, 3-5 parts of ethidene diamine, 6-7 parts of hexamethylenediamine, 5-8 parts of methyl pentamethylene diamine, 3-5 parts of propionic acid and 2-3 parts of acrylic acid through condensation reaction, and a defoaming agent (10-15) ml / ton. The alcohol-soluble polyamide resin for ink provided by the invention is non-toxic, free of pungent smell, non-corrosive, non-combustible, non-explosive, excellent in adhesive force, excellent in gloss, particularly strong in freezing resistance and gel resistance, excellent in alcohol solubility, stability and solvent release property, and can be used for preparing gravure plastic film surface printing ink.

The invention relates to a method for preparing a nerofloxacin chiral piperidylamine intermediate, which comprises the following steps of: carrying out condensation reaction on 5-hydroxy nicotinic acid which is simple and easy to obtain and is used as a raw material and different alcohols, screening through a series of asymmetric catalytic hydrogenation conditions to obtain optimal reaction conditions, and under the conditions, carrying out reaction on various 3, 3 '-dihydroxy nicotinic acid and 3, 3'-dihydroxy nicotinic acid to obtain the nerofloxacin chiral piperidylamine intermediate. The 2, 5-disubstituted pyridine quaternary ammonium salt is reduced into a tetrahydropyridine product, and the C5 site enantioselectivity of the product is excellent. The preparation method comprises the following steps: selecting methyl (R)-1-benzyl-5-hydroxy-1, 4, 5, 6-tetrahydropyridine-3-carboxylic acid methyl ester as a substrate, completely hydrogenating by using platinum dioxide hydrogen, and then carrying out methyl ester reduction, dehydroxylation, Mitsunobu reaction and protecting group removal to obtain a key chiral intermediate for industrial synthesis of a quinolone antibacterial drug nemonofloxacin with high enantioselectivity and high yield.

The invention provides a multi-scale super-amphiphobic anti-wax coating and a preparation method thereof.The preparation method comprises the following steps that S1, cellulose nanofibers are added into an ethyl alcohol-water mixed solution, after ultrasonic treatment and uniform stirring are conducted, sodium methyl silicate is added for stirring reaction, then fluorosilane and tetraethoxysilane are added for hydrolytic condensation reaction, and a mixed solution is obtained; centrifuging and drying to obtain multi-scale fluorinated micro-nano particles; and S2, mixing the multi-scale fluorinated micro-nano particles, an adhesive and a diluent in proportion, performing ultrasonic stirring, spraying the mixture on a base material, and curing to obtain the multi-scale amphiphobic paraffin-proof coating. Hydrophobic modification is carried out on cellulose nanofibers by using fluorosilane, sodium methyl silicate and tetraethoxysilane to form a multi-scale micro-nano multilevel structure, and the structure can effectively capture air and is combined with ground surface energy, so that the coating has excellent super-amphiphobic performance.