998 results about "Acylation" patented technology

The invention discloses a hydrogel wound dressing with a synergistic healing promoting function as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, dissolving oxidized methacrylated hyaluronic acid and dopamine in deionized water to obtain a solution A; the preparation method comprises the following steps: dissolving N-isopropylacrylamide, a photoinitiator 2-hydroxy-2-methyl-1-(4-(2-hydroxyethoxy) phenyl)-1-acetone and a cross-linking agent N, N '-methylene bisacrylamide in deionized water to obtain a solution B; 2, mixing the solution A and the solution B to obtain a pre-gel solution; or dissolving polyphenylboronic acid ester nanoparticles or polyphenylboronic acid ester-kaempferol with deionized water to obtain a solution C, and mixing the solution C with the solution A and the solution B to obtain a pre-gel solution; and 3, injecting the pre-gel liquid into a mold, and illuminating to obtain the hydrogel wound dressing loaded with the nanoparticles. The hydrogel disclosed by the invention can be used for effectively solving various problems in a wound healing process and promoting rapid and high-quality healing of a wound.

The invention provides an electrochemical luminescence MeHA microneedle patch and a preparation method and application thereof.The preparation method comprises the steps that hyaluronic acid is modified into methacrylated hyaluronic acid, MeHA solid powder is obtained after purification, and the MeHA solid powder is mixed with a photoinitiator to form a precursor solution; and pouring into a microneedle mold, centrifuging, drying and carrying out UV crosslinking to obtain the MeHA microneedle patch loaded with ABEI and glucose oxidase. Through the MeHA microneedle patch-SPE electrode integrated design, the integrated operation of skin interstitial fluid in-situ extraction-enzymatic reaction-electrochemical luminescence detection is realized, sample transfer is not needed, the interference of intermediate links is greatly reduced, the detection accuracy and efficiency are remarkably improved, and the device and the method are particularly suitable for clinical real-time monitoring scenes.

The invention discloses ternary synergistic nano-enzyme hydrogel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving zinc nitrate hexahydrate and ferric nitrate nonahydrate in methanol; dissolving 2-methylimidazole in methanol, adding into a metal salt solution, stirring, and sequentially centrifuging, washing and drying to obtain Fe / ZIF-8 nano-enzyme; the preparation method comprises the following steps: adding methacrylated gelatin and hyaluronic acid into deionized water, stirring, cooling to room temperature, and refrigerating to obtain a GelMA-HA precursor solution; and adding the Fe / ZIF-8 nano-enzyme into the GelMA-HA precursor solution, stirring, injecting into a mold, and carrying out ultraviolet light cross-linking curing to obtain the ternary synergistic nano-enzyme hydrogel. According to the hydrogel disclosed by the invention, active oxygen is efficiently removed and oxygen is produced through Fe / ZIF-8 nano-enzyme, and cartilage repair is promoted in combination with lubrication and slow release functions of gelatin hydrogel, so that a new strategy is provided for treatment of osteoarthritis.

The invention relates to the technical field of enzyme engineering, in particular to an acylase mutant and a biosynthesis method of (R)-2-aminobutanol.The acylase mutant comprises at least one of mutation of the following sites relative to wild type acylase with the amino acid sequence being SEQ ID NO: 1: T106, A625 and S413. The acylase mutant disclosed by the invention is used for synthesizing (R)-2-aminobutanol through biological catalysis, and the reaction route is as follows: the catalytic efficiency of a product is remarkably improved by the mutant, and the ee value of a chiral product is improved; according to the synthesis method, the problem of chiral resolution in the prior art is solved, the production cost is reduced, and pollution is reduced.

The invention belongs to the technical field of biology, and particularly relates to a high-throughput preparation method of a single-cell-derived organoid based on a microcapsule spherical shell structure, and the preparation method comprises the following steps: preparing an aqueous two-phase microcapsule encapsulated with a single cell, culturing the single cell in the aqueous two-phase microcapsule to obtain the organoid, the substances of the inner phase and / or the outer phase respectively comprise any one or a combination of more of the following substances: methacrylated gelatin, carboxymethyl cellulose, glucan, sodium alginate and polyvinyl alcohol. The invention also provides the organoid prepared by the preparation method and application of the preparation method. According to the invention, the microcapsule with a permeable core-shell structure is formed by packaging the microcapsule in a single-cell form in two-aqueous-phase liquid drops, the wrapping rate is effectively controlled and adjusted on the premise of conforming to Poisson distribution by optimizing parameters, and the single-cell wrapping rate and the organoid single-cell induction efficiency are optimized.

The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.

The invention relates to the technical field of polyurethane, and discloses hyperbranched polyurethane with high tensile strength and a preparation method thereof, maleic anhydride grafted POE and hydroxyethylamine p-amino triazine compound are subjected to acylation ring opening to obtain polyhydroxy triazine crosslinked POE; the preparation method comprises the following steps: reacting isophorone diisocyanate with polypropylene carbonate glycol at first, and then reacting with polyhydroxy triazine cross-linked POE (Polyolefin Elastomer) to obtain hyperbranched polyurethane with high tensile strength. The prepared polyhydroxy triazine cross-linked POE contains more reaction sites, the reaction cross-linking degree can be improved when the polyhydroxy triazine cross-linked POE reacts with a prepolymer, the polyhydroxy triazine cross-linked POE further contains unreacted hydroxyl, amino and other strong polar groups, intermolecular hydrogen bonds are formed, in addition, the maleic anhydride grafted POE elastomer can also absorb a large amount of impact energy, and the impact strength of the polyhydroxy triazine cross-linked POE is improved. The mechanical properties such as tensile strength of the hyperbranched polyurethane are further improved.

The invention relates to the field of aquatic feed, and provides a low-temperature adhesive type aquatic feed particle composition and a preparation method thereof. The composition is composed of puffed soybean meal, flour, fish meal, low-temperature directed enzyme, microcrystalline cellulose, modified zein nanoparticles, a protein adhesive and a modified zein ethanol water solution. The preparation method comprises the following specific steps: reacting soybean protein isolate with cross-linking enzyme to generate a protein adhesive, reacting proanthocyanidins with gallic acid to generate gallic acylated proanthocyanidins, and carrying out multi-step treatment on zein. Experimental results show that the composition has excellent water resistance and oxidation resistance, and the growth efficiency and the survival rate of aquatic animals are remarkably improved. The preparation method is simple, the cost is low, heat-sensitive substances in the feed are not damaged, and an economical, efficient and nutrient-rich feed solution is provided for aquaculture.

The invention discloses a photocuring microneedle with ginseng exosome loaded berberine, a preparation method of the photocuring microneedle and application of the photocuring microneedle to tissue repair. A ginseng exosome loaded berberine compound is prepared through a microfluidic technology; filling a needle cavity of a microneedle mold with a needle tip layer preparation solution containing the compound, methylacryloylated hyaluronic acid and methylacryloylated gelatin through a centrifugal method; covering a backing layer preparation solution composed of hyaluronic acid and povidone K90, and centrifuging again; and finally, carrying out light curing, drying and demolding. The prepared composite microneedle is complete and sharp in needle shape and high in forming rate; the efficient entrapment of the active medicine is realized; the biocompatibility is good, and the irritation is low; a cross-linked network structure formed by photocuring is beneficial to realizing controlled release of drugs, the targeted repair function of the ginseng exosome is combined with the hypoglycemic effect of berberine, and a new strategy and technical approach with a prospect are provided for painless, efficient and long-acting treatment of diabetes mellitus.

The invention relates to the technical field of rice bran processing, and discloses a rice bran degreasing and nutrition retention edible process synergistic treatment method which comprises the following steps: (a) in an NADES-aqueous solution medium, adding an immobilized catalyst A, and hydrolyzing ferulate bonds and phospholipids in rice bran at low temperature; (b) carrying out intermediate dehydration on the slurry obtained in the step (a) to reduce the water activity; (c) adding an immobilized catalyst B into the dehydrated slurry in the step (b), carrying out esterification reaction, and grafting free ferulic acid generated by hydrolysis to glyceride in situ; and (d) carrying out solid-liquid separation on the slurry obtained in the step (c) to obtain finished oil and finished powder. According to the method, an NADES medium is adopted to replace an organic solvent, the whole process is carried out at low temperature, degradation of heat-sensitive nutrient substances is avoided, and resource utilization of ferulic acid is achieved. The prepared functional rice bran oil is rich in feruloyl glyceride, total tocopherol and oryzanol, and is low in acid value and peroxide value.

The invention belongs to the technical field of hydrogel preparation, and discloses a biocompatible self-healing photocuring hydrogel and a preparation method and a use method thereof.The biocompatible self-healing photocuring hydrogel is prepared by adding an ultraviolet light initiator and sodium chloride into a polyvinyl alcohol aqueous solution, evenly mixing, then adding acryloyl glycinamide powder to enable the acryloyl glycinamide powder to be dissolved, then adding a crosslinking agent, and evenly mixing to obtain the biocompatible self-healing photocuring hydrogel. Adding water into the mixed solution, then removing bubbles, then adding methacrylated gelatin and dissolving, and then removing bubbles to obtain a biocompatible self-healing photocuring hydrogel mixed solution; adding a borax solution prepared from sodium tetraborate and deionized water into the obtained biocompatible self-healing light-cured hydrogel mixed solution, and after the biocompatible self-healing light-cured hydrogel mixed solution and the borax solution are subjected to cross-linking reaction, removing bubbles to obtain the biocompatible self-healing light-cured hydrogel. The biocompatible self-healing photocuring hydrogel has excellent mechanical properties and self-healing ability, and is suitable for application scenes such as biosensing, wound repair and tissue engineering.

The present application relates to a kind of powder coating hydroxyalkylamide matting curing agent and its preparation method, the matting curing agent using including citric acid, 2-methyl-1,3-propanediol, dimethylbenzene, anhydrous methanol, N-methyl monoethanolamine, catalyst, nanometer titanium dioxide is reacted to obtain raw materials.In first, citric acid and 2-methyl-1,3-propanediol are grafted to carry out reaction, then the remaining four carboxyl groups of grafting are methyl esterification reaction, obtain methyl esterification product, then with N-methyl monoethanolamine acylation reaction obtains hydroxyalkylamide curing agent;Add nanometer titanium dioxide, fully mix and process to obtain the matting curing agent.The curing agent product functionality is higher, the hardness of coating film after curing is higher, and the boiling water resistance is excellent;And the coating film after curing has obvious matting effect, coating film gloss is basically reached 50-70%, and the decorative property is excellent.

Provided are a new acylated insulin, a pharmaceutical preparation thereof, a pharmaceutical composition thereof containing a long-acting GLP-1 compound, and the medical use of the acylated insulin, the pharmaceutical preparation and the pharmaceutical composition.

The invention discloses a method for preparing 1, 3-propylene glycol by hydrating and hydrogenating acrolein, which comprises the following steps: carrying out hydration reaction by taking an acrolein aqueous solution as a raw material and taking acylated and aminated modified polystyrene resin as a catalyst; carrying out flash evaporation or gas stripping on the product after the reaction to remove acrolein, condensing and recovering the removed acrolein, and carrying out hydrogenation reaction on the acrolein-removed mixed solution serving as a hydrogenation raw material on a metal catalyst; and after the reaction is finished, performing flash evaporation on the product to remove water and light components, and performing vacuum rectification to obtain a high-purity 1, 3-propylene glycol product. According to the method, the modified resin is used for catalyzing the acrolein hydration reaction, the overall yield of the 1, 3-propylene glycol can be increased, the catalyst modification process is simple, the cost is low, the additional value of the final product is high, and the method is suitable for industrial production.

The invention discloses an application of beta-alanine in preparation of a medicine for treating pulmonary arterial hypertension. In-vivo and in-vitro pharmacological experiments prove that beta-alanine can inhibit lactic acid-mediated histone milk acylation modification and hypoxia-induced phenotypic transformation of PASMCs (Polyaspartic Sulfonate Molecules); the hemodynamics and pulmonary artery vascular remodeling of the PAH mouse are improved. The beta-alanine can inhibit phenotypic transformation of PASMCs and reverse pulmonary artery vascular remodeling which is a key pathological change in the pulmonary hypertension generation process, has huge potential in treatment of pulmonary hypertension, and has good application prospects and high clinical application value.

The invention relates to the technical field of fire-fighting materials, in particular to a fire-retardant thermosensitive self-crosslinking hydrogel fire extinguishing agent and a preparation method thereof. In order to solve the technical problems that an existing hydrogel fire extinguishing agent is limited in fire retardance effect, and especially for a high-temperature fire source, the existing hydrogel fire extinguishing agent is difficult to achieve a good fire retardance effect, the invention discloses a fire retardance type thermosensitive self-crosslinking hydrogel fire extinguishing agent which comprises the following components in percentage by mass: 0.05-1% of aryl sulfonylated carboxymethyl cellulose, 0.05-1% of a cross-linking agent, 0.05-1% of a cross-linking agent and the balance of water. 0.1%-2% of a first thickening agent; 0.1%-2% of a second thickening agent; 0.3 to 3 percent of a surfactant; 0.5-5% of a first flame retardant; 0.5 to 5% of a second flame retardant; and the other component is a solvent. The fire-retardant thermosensitive self-crosslinking hydrogel fire extinguishing agent can be used for rapid extinguishing and after-combustion inhibition of a high-temperature (less than or equal to 700 DEG C) fire source. And a good fire retardant effect is achieved.

The application relates to a cartilage organoid based on a DNA-silk fibroin hybrid hydrogel sustained-release system and a preparation method and application thereof. The DNA-silk fibroin hybrid hydrogel sustained-release system is a hydrogel system after a DNA-silk fibroin hybrid hydrogel sustained-release system premixing solution is printed through a digital light processing system, wherein the DNA-silk fibroin hybrid hydrogel sustained-release system premixing solution contains DNA, silk fibroin, acrylated RGD peptide, acrylated polyethylene glycol NHS ester, glucosamine, TD-198946 and 2,4,6-trimethylbenzoyl lithium phosphate. Compared with the prior art, the glucosamine and TD-198946 introduced in the DNA-silk fibroin hybrid hydrogel sustained-release system can significantly improve the cartilage differentiation efficiency of bone marrow mesenchymal stem cells; and the application can be transplanted to a cartilage defect as a cartilage graft to promote cartilage regeneration and repair.

The invention provides a preparation method of a (S)-5-(2, 2-dimethyl tetrahydro-2H-pyran-4-yl)-N-methyl-N-phenyl-1H-indole-2-formamide compound, which comprises the following steps: by taking a compound 1 as an initial raw material, reacting the compound 1 with a boric acid ester reagent to obtain a boric acid ester compound 2; the method comprises the following steps: by taking a compound 3 as an initial raw material, reducing carbonyl through enzyme catalysis to obtain a compound 4, then protecting alcoholic hydroxyl through a sulfonylation reagent to obtain a compound 5, and finally, directly coupling the compound 5 with a compound 2 under the action of a catalyst to obtain a target product compound 6. The whole process is low in experimental condition requirement, simple to operate, high in yield and suitable for process amplification.

The invention relates to the technical field of biomedical material modification, in particular to a sulfhydrylation biocompatible polymer derivative, a preparation method thereof, extracellular matrix imitating injectable in-situ cross-linked hydrogel and application thereof. According to the invention, a pre-acylation strategy is firstly carried out on the biocompatible polymer containing both amino and carboxyl, so that a three-dimensional cross-linked byproduct formed by coupling of self amido bonds is avoided, meanwhile, the number of side chain carboxyl for sulfhydrylation modification is increased, and the accurate and adjustable pre-acylation rate can optimize the physical and chemical properties of the derivative; meanwhile, a disulfide bond is used as a protective precursor, active sulfydryl is introduced through amido bond coupling, self-oxidation of the active sulfydryl in the reaction process is avoided, sulfydryl activity is guaranteed, hydrazine-containing reagents are avoided, safety is further improved, virus residues and immunological rejection risks are avoided, universality is high, and the application prospect is wide; and in combination with a high-concentration preparation method, the method has the advantage of large-scale production, and further widens the industrial application potential.

The invention belongs to the technical field of biological fouling protection, and particularly relates to an environment-friendly adhesive hydrogel antifouling coating which is prepared by the following steps: grafting a catechol group to an acryloyl compound with double bonds through acylation reaction to obtain a dopamine-acrylamide compound; the preparation method comprises the following steps: carrying out copolymerization reaction on an acrylamide derivative and a dopamine-acrylamide compound in a water environment to obtain an acrylamide derivative copolymer; and mixing the chitosan and the acrylamide derivative copolymer to obtain the environment-friendly adhesive hydrogel antifouling coating. According to the invention, polyacrylamide and catechol are introduced into a chitosan system at the same time to form a chitosan-polyacrylamide-catechol ternary synergistic network, and the chitosan-polyacrylamide-catechol ternary synergistic network has the effects of self-repairing, high toughness, strong adhesion and intelligent response.

A method for inactivating pathogens is described, comprising the steps of: partially deacylating a poly(2-alkyl-2-oxazoline) to yield a copolymer, an alkyl in the poly(2-alkyl-2-oxazoline) comprising a hydrocarbon chain, the copolymer comprising: first monomers, the first monomers comprising a -NH2 +CH2CH2- group; and second monomers, the second monomers comprising an acyl group, -C(=O)-R', attached to a nitrogen in a polymer backbone group comprising -NCH2CH2-, wherein R' comprises the hydrocarbon chain, the first monomers and the second monomers arranged in any order in the copolymer; preparing a formulation, the formulation comprising the copolymer and a total cationic charge in a range of 0.2 to 10 C / cm3, the total cationic charge at least 95% offset by counteranions in the formulation; contacting the pathogens with the formulation; and inactivating at least ninety percent of the pathogens within ninety minutes of the step of contacting.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a benzocrown ether derivative and a synthesis method thereof. According to the invention, carboxylic acid or substituted carboxylic acid as shown in a general formula I, benzocrown ether as shown in a general formula II and substituted terephthalaldehyde as shown in a general formula IV are used as raw materials, and two kinds of benzocrown ether derivatives as shown in a general formula (A) and a general formula (B) are synthesized through Friedel-Crafts acylation reaction, reduction reaction and substitution reaction. The preparation method provided by the invention has the advantages of simple and easily available raw materials, simple post-treatment, high yield, good universality, environmental friendliness and the like. The two benzocrown ether derivatives as shown in the general formula (A) and the general formula (B), which are disclosed by the invention, serve as important organic synthesis intermediates and have great research values in the aspects of ion recognition, material preparation, medicine synthesis and the like.

The invention discloses a dual-band dianthracene photocatalyst as well as a preparation method and application thereof, and belongs to the field of heterocyclic compounds. The novel 2, 9 '-dianthracene photocatalyst is designed and synthesized, the compatibility at the two wavebands of 365 nm and 405 nm is good, the tetrahydroisoquinoline phosphoramidite can be induced by light, and a new thought is provided for preparing an alpha-phosphoramidate compound; the reaction conditions are mild, the reaction time is short, the photocatalyst can be recycled, the circulation loss is low, the circulation efficiency is high, the production efficiency is greatly improved, and the production period and cost are reduced; the product is free of transition metal residues and high in yield.

The invention provides isosorbide-based copolyester as well as a preparation method and application thereof, and relates to the technical field of high polymer materials. According to the preparation method, a step-by-step esterification method is adopted, firstly, isosorbide, excessive aromatic dicarboxylic acid and an acylating agent are subjected to a first esterification reaction, so that the acylating agent can efficiently and specifically activate secondary hydroxyl of isosorbide, and the initial esterification rate of isosorbide is greatly increased. Meanwhile, the excessive aromatic dicarboxylic acid ensures that the generated isosorbide prepolymer takes carboxyl as a terminal group, so that isosorbide molecules are'locked 'in the middle of a polymer chain segment. Due to the fact that the isosorbide is embedded in the middle of the chain segment in advance, the problem that the isosorbide falls off in the ester exchange reaction due to the fact that the isosorbide is located at the chain end and low in reaction activity in the subsequent polycondensation stage is effectively solved, and therefore the retention rate of the isosorbide in the final polymer is greatly increased, and the glass-transition temperature of the isosorbide is greatly increased.

The invention discloses a synthetic method of photosensitive composite hydrogel and application of the photosensitive composite hydrogel in treatment of periodontitis. The composition expression of the photosensitive composite hydrogel is MHA-B-coated Lipo, and the photosensitive composite hydrogel is prepared by the following steps: entrapping berberine hydrochloride by lipidosome with proton gradient, and then mixing with methacrylated hyaluronic acid, a photoinitiator and a cross-linking agent; according to the liposome with the proton gradient, a citric acid buffer solution is adopted for preparing blank liposome, and then alkali liquor is used for adjusting the pH value of an external phase to be alkalescent, so that the transmembrane gradient is formed. The liposome is used as a drug delivery carrier, berberine is entrapped in the liposome and is combined with the MHA hydrogel to form a composite sustained-release drug, and the composite sustained-release drug has the advantages of strong targeting property, good responsiveness, good biocompatibility and high biological safety; and the hydrogel has injectable and photosensitive cross-linking characteristics, is suitable for clinical minimally invasive operation, has the advantages of accurate immune regulation and control, and has a wide application prospect.

The invention discloses a preparation process of high-purity dotenorad, and belongs to the technical field of organic synthesis route design and raw material medicine and intermediate preparation. Benzothiazole is used as a starting material, reduction, acylation, amide condensation, oxidation, demethylation and other reactions are sequentially carried out, a dotenorad crude product is synthesized, and the required crystal form is obtained through recrystallization. The raw materials of the preparation method are cheap, easy to obtain and high in stability, the defect that the raw materials of other preparation processes are poor in stability is overcome, and the preparation method is convenient to operate and suitable for industrial production; the total yield of the prepared dotenorad in each step is 66.80%, and the purity of the dotenorad can reach 99.99%.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of an olefin monomer of benzocrown ether imidazole polymerized ionic liquid. Comprising the following steps: adding benzo-12-crown-4-ether, iodo-alkyl acid and polyphosphoric acid into a heat preservation kettle, carrying out heating reaction, adding chloro-alkyl acid, carrying out heating reaction, dropwise adding water to hydrolyze residual polyphosphoric acid, extracting an organic phase by chloroform, washing chloro-alkyl acid by using a sodium carbonate aqueous solution, drying, carrying out suction filtration, and transferring into a reaction kettle; adding 1-methylimidazole, carrying out heating reaction, carrying out rotary evaporation to obtain chloroform, adding dioxane, triethylamine and hydroquinone, carrying out heating reaction, and carrying out rotary evaporation to obtain dioxane; the ionic liquid, organic salt and pure water are added into a dissolving kettle, dichloromethane is used for extracting an organic phase, pure water is used for washing chloride ions and iodide ions in the organic phase, dichloromethane is obtained through rotary evaporation, and a product is dried in vacuum. According to the method, the steps of acylation, quaternization and dehydrohalogenation are used, so that the steps are simplified, and the purification treatment process of acylation after quaternization is avoided.

The invention relates to the technical field of functional fiber materials, and particularly discloses an antistatic fiber, an antistatic textile and antistatic underwear prepared from the antistatic fiber and the antistatic textile. The antistatic fiber is prepared from the following components in parts by weight: 88 to 94 parts of polyethylene glycol terephthalate, 3 to 8 parts of polyether ester segmented copolymer, 0.5 to 1.2 parts of electronic conductive agent, 0.3 to 0.8 part of dispersing agent, 0.2 to 0.5 part of antioxidant and 1.0 to 2.0 parts of toughening agent. Wherein the electronic conductive agent is a sulfonated polyether ester grafted carbon nanotube, and is prepared by reacting a carboxylated multi-walled carbon nanotube with sulfonated polyether ester in an organic solvent in the presence of a coupling agent and an acylation catalyst. The invention further provides a preparation method of the antistatic fiber. The preparation method comprises the steps of functional master batch preparation, mixing and drying and melt spinning. The antistatic textile prepared from the fiber and the antistatic underwear prepared from the antistatic textile have good antistatic performance and durability.

A diesel fuel composition including (a) a quaternary ammonium salt additive; and (b) one or more nitrogen-free detergents; wherein the quaternary ammonium salt additive includes the quaternised reaction product of a hydrocarbyl substituted succinic acid derived acylating agent and a compound able to react with said acylating agent and which includes a tertiary amine group; wherein each molecule of the hydrocarbyl substituted succinic acid derived acylating agent includes on average at least 1.2 succinic acid moieties.

Provided are CRF2 receptor agonists as defined by Chemical Formulas 1 and 2 and fatty acid conjugates thereof.