1378 results about "Acylation" patented technology

The present invention belongs to the technical field of biomedical materials. Disclosed are a methacrylate, a succinate-diesterified starch, a preparation method therefor and the use thereof in an in-situ filler for corneal defects. The methacrylate, succinate-diesterified starch is prepared by means of performing graft carboxylation on starch and then grafting a double bond. The in-situ filler for corneal defects consists of the methacrylate succinate-diesterified starch (StacMA), gelatin methacryloyl (GelMA), a photoinitiator and a solvent. The corneal filler has a good biocompatibility, an excellent photoresponsive adhesion property and excellent mechanical properties, and can be used for promoting the regeneration of the natural structure of a damaged cornea and the reconstruction of visual function.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of bromo-pyrrole nitrile. The method comprises the following steps: (1) mixing p-chlorophenylglycine, acetonitrile, trifluoroacetic acid and a catalyst, then dropwise adding acyl chloride and carrying out acylation reaction, and after the reaction is completed, purging with an inert gas; (2) under the inert gas, mixing the mixture obtained in the step (1) with inorganic salt, then dropwise adding 2-chloroacrylonitrile, carrying out cyclization reaction, and separating a liquid phase from the obtained mixture; and (3) under the inert gas, mixing the liquid phase obtained in the step (2), hydrobromic acid and hydrogen peroxide, carrying out a bromination reaction, then extracting with acetonitrile to obtain an acetonitrile layer, then removing the acetonitrile, and then carrying out cooling crystallization to obtain the bromo-pyrrolenitrile. According to the technical scheme, the reaction yield is high, different solvents do not need to be frequently replaced, and the solvents can be recycled.

A method for separating amoxicillin and phenylacetic acid from reaction solution in one-step enzymatic synthesis of amoxicillin is provided. The method employs immobilized penicillin acylase mutant to catalyze the one-step synthesis of amoxicillin from penicillin potassium, and develops a separation process for the resulting reaction mixture. The technical scheme mainly comprises: Firstly separating the immobilized penicillin acylase mutant from the reaction solution through filtration; subsequently isolating amoxicillin via crystallization; followed by separating and recovering phenylacetic acid through toluene extraction and back extraction. This separation method enables rapid and efficient isolation of amoxicillin with high production yield, achieving an average crystallization rate of 93.22%. Concurrently, it demonstrates effective separation and recovery of phenylacetic acid while allowing recyclable use of the toluene extractant.

The invention discloses a glue solution for a copper-clad plate and a preparation method of the glue solution, and relates to the technical field of copper-clad plates. According to the prepared glue solution for the copper-clad plate, the composite epoxy resin, the curing agent, the accelerant, the solvent, the flexibilizer and the inorganic filler, the composite epoxy resin comprises bisphenol A epoxy resin, epoxy phenyl polysiloxane, itaconic acid polyaryletherketone and hydroxyl-terminated fluorine-containing vinyl polysiloxane, so that the interface bonding force with the copper plate is enhanced; the dielectric constant and the dielectric loss are effectively reduced, the peel strength and the toughness of the material are also remarkably improved, and the toughening agent is modified polyether sulfone microspheres; the modified polyethersulfone microspheres are prepared by coating polyethersulfone microspheres with hexamethylenediamine tetrapropionamide diamine, the hexamethylenediamine tetrapropionamide diamine is prepared by carrying out acylation condensation reaction on hexamethylenediamine tetramethyl propionate and ethylenediamine, and the polyethersulfone microspheres are prepared by carrying out electrostatic spinning on a spinning solution of polyethersulfone and vinylpyridine, so that the peel strength of the glue solution is remarkably improved.

The invention discloses a preparation method of 4-bromo-2-(4-chlorphenyl)-5-trifluoromethyl-1H-pyrrole-3-formonitrile, and belongs to the technical field of organic synthesis.The preparation method comprises the steps of acylation reaction, cyclization reaction, bromination reaction and recovery. The preparation method disclosed by the invention is high in safety, the prepared 4-bromo-2-(4-chlorphenyl)-5-trifluoromethyl-1H-pyrrole-3-formonitrile is high in purity and yield, the equipment investment is small, the bromination reaction speed is high, the acid-binding agent can be recycled, the drying time during recycling is short, and the water content in the recycled acid-binding agent is low.

The invention discloses a hydrogel wound dressing with a synergistic healing promoting function as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, dissolving oxidized methacrylated hyaluronic acid and dopamine in deionized water to obtain a solution A; the preparation method comprises the following steps: dissolving N-isopropylacrylamide, a photoinitiator 2-hydroxy-2-methyl-1-(4-(2-hydroxyethoxy) phenyl)-1-acetone and a cross-linking agent N, N '-methylene bisacrylamide in deionized water to obtain a solution B; 2, mixing the solution A and the solution B to obtain a pre-gel solution; or dissolving polyphenylboronic acid ester nanoparticles or polyphenylboronic acid ester-kaempferol with deionized water to obtain a solution C, and mixing the solution C with the solution A and the solution B to obtain a pre-gel solution; and 3, injecting the pre-gel liquid into a mold, and illuminating to obtain the hydrogel wound dressing loaded with the nanoparticles. The hydrogel disclosed by the invention can be used for effectively solving various problems in a wound healing process and promoting rapid and high-quality healing of a wound.

The invention provides an electrochemical luminescence MeHA microneedle patch and a preparation method and application thereof.The preparation method comprises the steps that hyaluronic acid is modified into methacrylated hyaluronic acid, MeHA solid powder is obtained after purification, and the MeHA solid powder is mixed with a photoinitiator to form a precursor solution; and pouring into a microneedle mold, centrifuging, drying and carrying out UV crosslinking to obtain the MeHA microneedle patch loaded with ABEI and glucose oxidase. Through the MeHA microneedle patch-SPE electrode integrated design, the integrated operation of skin interstitial fluid in-situ extraction-enzymatic reaction-electrochemical luminescence detection is realized, sample transfer is not needed, the interference of intermediate links is greatly reduced, the detection accuracy and efficiency are remarkably improved, and the device and the method are particularly suitable for clinical real-time monitoring scenes.

The invention belongs to the technical field of biology, and relates to a mutant of horse-derived acylase with high pH stability, a coding gene and application of the mutant in catalytic generation of lauroyl glycine. The horse-derived acylase mutant sequence disclosed by the invention has the advantages of high enzyme activity stability in a wider pH environment, high synthesis efficiency of lauroyl glycine and very high production and application values.

The invention relates to the technical field of bentonite anti-seepage materials, and particularly discloses a pre-hydrated bentonite anti-seepage material and a preparation process thereof. The modified bentonite is prepared by mixing the following raw materials in parts by mass: 80-90 parts of calcium bentonite, 10-12 parts of a binder, 5-8 parts of an organic composite component and 3-5 parts of ethylene carbonate, the preparation method comprises the following steps: taking calcium bentonite, crushing, sieving, adding water for dispersing, adjusting the pH value, adding ethylene carbonate, heating and stirring, adding the organic composite component, continuously treating, filtering, taking a solid part, adding a binder, mixing, laminating, carrying out mold pressing treatment, and cooling, thereby obtaining the product. Wherein the organic composite component is obtained by amino-terminated modification of acylated polyethylene glycol. The water absorption rate of the pre-hydrated bentonite anti-seepage material prepared by the preparation process is greater than or equal to 5.2, the water retention rate is greater than or equal to 63.7%, and the elution risk of intercalator micromolecules can be greatly reduced.

The invention discloses ternary synergistic nano-enzyme hydrogel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving zinc nitrate hexahydrate and ferric nitrate nonahydrate in methanol; dissolving 2-methylimidazole in methanol, adding into a metal salt solution, stirring, and sequentially centrifuging, washing and drying to obtain Fe / ZIF-8 nano-enzyme; the preparation method comprises the following steps: adding methacrylated gelatin and hyaluronic acid into deionized water, stirring, cooling to room temperature, and refrigerating to obtain a GelMA-HA precursor solution; and adding the Fe / ZIF-8 nano-enzyme into the GelMA-HA precursor solution, stirring, injecting into a mold, and carrying out ultraviolet light cross-linking curing to obtain the ternary synergistic nano-enzyme hydrogel. According to the hydrogel disclosed by the invention, active oxygen is efficiently removed and oxygen is produced through Fe / ZIF-8 nano-enzyme, and cartilage repair is promoted in combination with lubrication and slow release functions of gelatin hydrogel, so that a new strategy is provided for treatment of osteoarthritis.

The invention relates to the technical field of enzyme engineering, in particular to an acylase mutant and a biosynthesis method of (R)-2-aminobutanol.The acylase mutant comprises at least one of mutation of the following sites relative to wild type acylase with the amino acid sequence being SEQ ID NO: 1: T106, A625 and S413. The acylase mutant disclosed by the invention is used for synthesizing (R)-2-aminobutanol through biological catalysis, and the reaction route is as follows: the catalytic efficiency of a product is remarkably improved by the mutant, and the ee value of a chiral product is improved; according to the synthesis method, the problem of chiral resolution in the prior art is solved, the production cost is reduced, and pollution is reduced.

The invention belongs to the technical field of biology, and particularly relates to a high-throughput preparation method of a single-cell-derived organoid based on a microcapsule spherical shell structure, and the preparation method comprises the following steps: preparing an aqueous two-phase microcapsule encapsulated with a single cell, culturing the single cell in the aqueous two-phase microcapsule to obtain the organoid, the substances of the inner phase and / or the outer phase respectively comprise any one or a combination of more of the following substances: methacrylated gelatin, carboxymethyl cellulose, glucan, sodium alginate and polyvinyl alcohol. The invention also provides the organoid prepared by the preparation method and application of the preparation method. According to the invention, the microcapsule with a permeable core-shell structure is formed by packaging the microcapsule in a single-cell form in two-aqueous-phase liquid drops, the wrapping rate is effectively controlled and adjusted on the premise of conforming to Poisson distribution by optimizing parameters, and the single-cell wrapping rate and the organoid single-cell induction efficiency are optimized.

The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.

The invention discloses an intaglio printing ink composition and an intaglio printing method, and belongs to the technical field of ink preparation, the intaglio printing ink composition comprises the following components by weight: 40-80 parts of a polyacrylic acid emulsion and / or a polyacrylate emulsion, 5-15 parts of a hydroxyl acrylate monomer, 4-12 parts of a cross-linking agent, and 5-15 parts of a low alcohol solvent, 8-26 parts of pigment filler, 1-8 parts of an initiator and 3-10 parts of an auxiliary agent; the cross-linking agent is formed by taking pentaerythritol as a matrix, preparing pentaerythritol ester containing bromo-isobutyl through acylation reaction ester formation, and then polymerizing with tert-butyl acrylate through atom transfer radical polymerization reaction. By introducing the cross-linking agent, the curing speed of the resin binder is increased, and meanwhile, the adhesive force and the stability of the ink are improved.

The present invention discloses a method for measuring the hydroxyl value of a polyether polyol using nuclear magnetic resonance phosphorus spectroscopy, comprising: 1) adding a polyether polyol sample to be tested and an internal standard bisphenol A to a deuterated reagent and dissolving them by ultrasonication; 2) adding a phosphorus oxychloride compound and an acid binding agent to the mixture and allowing them to react fully to obtain corresponding different derivatized phosphorus-containing products; 3) performing a phosphorus spectroscopy test in a nuclear magnetic resonance analyzer to obtain nuclear magnetic resonance phosphorus spectroscopy data, processing and analyzing the data, integrating the nuclear magnetic resonance characteristic peak areas of the phosphorus-containing products after derivatization of the polyether polyol sample and the internal standard bisphenol A, and normalizing them to 100%, and calculating the hydroxyl value of the sample to be tested based on the molar ratio relationship between the products. The hydroxyl value result obtained by the present method has a relative deviation of less than 5% from the result obtained by the phthalic anhydride acylation method in the national standard GB / T 12008.3-2009, and the two results are close and highly accurate. The analytical testing method of the present invention is simple, has low pollution, and is short in time.

The invention provides a resveratrol preparation method, which comprises: mixing a compound 1 and an acylation reagent in an organic solvent, carrying out a reaction to obtain a compound 2, adding chlorobenzene and a catalyst, and carrying out a Friedel-Crafts reaction on the compound 2 and chlorobenzene under the ultraviolet light condition to obtain a compound 3, oxidizing the compound 3 to obtain 1-(4-phenol)-2-(3, 5-dihydroxyphenyl) ethanone; the preparation method comprises the following steps: reducing 1-(4-phenol)-2-(3, 5-dihydroxyphenyl) ethanone to obtain 1-(4-phenol)-2-(3, 5-dihydroxyphenyl) ethanol; and removing an alcoholic hydroxyl group in the 1-(4-phenol)-2-(3, 5-dihydroxyphenyl) ethanol to obtain the resveratrol.

The invention relates to the technical field of polyurethane, and discloses hyperbranched polyurethane with high tensile strength and a preparation method thereof, maleic anhydride grafted POE and hydroxyethylamine p-amino triazine compound are subjected to acylation ring opening to obtain polyhydroxy triazine crosslinked POE; the preparation method comprises the following steps: reacting isophorone diisocyanate with polypropylene carbonate glycol at first, and then reacting with polyhydroxy triazine cross-linked POE (Polyolefin Elastomer) to obtain hyperbranched polyurethane with high tensile strength. The prepared polyhydroxy triazine cross-linked POE contains more reaction sites, the reaction cross-linking degree can be improved when the polyhydroxy triazine cross-linked POE reacts with a prepolymer, the polyhydroxy triazine cross-linked POE further contains unreacted hydroxyl, amino and other strong polar groups, intermolecular hydrogen bonds are formed, in addition, the maleic anhydride grafted POE elastomer can also absorb a large amount of impact energy, and the impact strength of the polyhydroxy triazine cross-linked POE is improved. The mechanical properties such as tensile strength of the hyperbranched polyurethane are further improved.

The invention relates to the field of aquatic feed, and provides a low-temperature adhesive type aquatic feed particle composition and a preparation method thereof. The composition is composed of puffed soybean meal, flour, fish meal, low-temperature directed enzyme, microcrystalline cellulose, modified zein nanoparticles, a protein adhesive and a modified zein ethanol water solution. The preparation method comprises the following specific steps: reacting soybean protein isolate with cross-linking enzyme to generate a protein adhesive, reacting proanthocyanidins with gallic acid to generate gallic acylated proanthocyanidins, and carrying out multi-step treatment on zein. Experimental results show that the composition has excellent water resistance and oxidation resistance, and the growth efficiency and the survival rate of aquatic animals are remarkably improved. The preparation method is simple, the cost is low, heat-sensitive substances in the feed are not damaged, and an economical, efficient and nutrient-rich feed solution is provided for aquaculture.

The invention discloses application of double enzymes in one-step preparation of L-selenium methyl selenocysteine, and belongs to the technical field of biochemical engineering. In the method, racemic N-acetyl selenium methyl selenocysteine is used, and the L-selenium methyl selenocysteine with high optical purity is prepared in a green and efficient manner through co-catalysis of stereoselective L amino acid acylase and N-acetyl amino acid racemase. The catalyst is prepared through fermentation by adopting a one-bacterium two-enzyme method. Synchronous racemization and selective hydrolysis are realized by a one-step method, the theoretical conversion rate is 100%, the actual conversion rate is 95%, and the product is e.egt; the concentration of the substrate is 8%.

The invention discloses a photocuring microneedle with ginseng exosome loaded berberine, a preparation method of the photocuring microneedle and application of the photocuring microneedle to tissue repair. A ginseng exosome loaded berberine compound is prepared through a microfluidic technology; filling a needle cavity of a microneedle mold with a needle tip layer preparation solution containing the compound, methylacryloylated hyaluronic acid and methylacryloylated gelatin through a centrifugal method; covering a backing layer preparation solution composed of hyaluronic acid and povidone K90, and centrifuging again; and finally, carrying out light curing, drying and demolding. The prepared composite microneedle is complete and sharp in needle shape and high in forming rate; the efficient entrapment of the active medicine is realized; the biocompatibility is good, and the irritation is low; a cross-linked network structure formed by photocuring is beneficial to realizing controlled release of drugs, the targeted repair function of the ginseng exosome is combined with the hypoglycemic effect of berberine, and a new strategy and technical approach with a prospect are provided for painless, efficient and long-acting treatment of diabetes mellitus.

The invention relates to the technical field of rice bran processing, and discloses a rice bran degreasing and nutrition retention edible process synergistic treatment method which comprises the following steps: (a) in an NADES-aqueous solution medium, adding an immobilized catalyst A, and hydrolyzing ferulate bonds and phospholipids in rice bran at low temperature; (b) carrying out intermediate dehydration on the slurry obtained in the step (a) to reduce the water activity; (c) adding an immobilized catalyst B into the dehydrated slurry in the step (b), carrying out esterification reaction, and grafting free ferulic acid generated by hydrolysis to glyceride in situ; and (d) carrying out solid-liquid separation on the slurry obtained in the step (c) to obtain finished oil and finished powder. According to the method, an NADES medium is adopted to replace an organic solvent, the whole process is carried out at low temperature, degradation of heat-sensitive nutrient substances is avoided, and resource utilization of ferulic acid is achieved. The prepared functional rice bran oil is rich in feruloyl glyceride, total tocopherol and oryzanol, and is low in acid value and peroxide value.

The invention discloses a photocuring hydrogel anticoagulant coating and a preparation method thereof, and belongs to the technical field of biomedicine. The preparation method comprises the following steps: firstly, preparing methacrylated polyvinyl alcohol, methacrylated heparin, a photoinitiator and water into a uniform coating dipping solution, dipping a substrate with a clean surface into the coating dipping solution for 5-100 minutes, taking out the substrate, airing, repeatedly dipping for 2-10 times, and curing the obtained substrate under ultraviolet excitation light to obtain the coating. The preparation process of the photocuring hydrogel anticoagulant coating is simple and easy to operate, the reaction condition is mild, and the prepared photocuring hydrogel anticoagulant coating has very good biocompatibility, can be firmly combined with a substrate material, has very excellent anticoagulant performance and has very good application prospects.

The invention belongs to the technical field of hydrogel preparation, and discloses a biocompatible self-healing photocuring hydrogel and a preparation method and a use method thereof.The biocompatible self-healing photocuring hydrogel is prepared by adding an ultraviolet light initiator and sodium chloride into a polyvinyl alcohol aqueous solution, evenly mixing, then adding acryloyl glycinamide powder to enable the acryloyl glycinamide powder to be dissolved, then adding a crosslinking agent, and evenly mixing to obtain the biocompatible self-healing photocuring hydrogel. Adding water into the mixed solution, then removing bubbles, then adding methacrylated gelatin and dissolving, and then removing bubbles to obtain a biocompatible self-healing photocuring hydrogel mixed solution; adding a borax solution prepared from sodium tetraborate and deionized water into the obtained biocompatible self-healing light-cured hydrogel mixed solution, and after the biocompatible self-healing light-cured hydrogel mixed solution and the borax solution are subjected to cross-linking reaction, removing bubbles to obtain the biocompatible self-healing light-cured hydrogel. The biocompatible self-healing photocuring hydrogel has excellent mechanical properties and self-healing ability, and is suitable for application scenes such as biosensing, wound repair and tissue engineering.

The invention discloses a rice hull fiber environment-friendly material and a preparation method thereof, and belongs to the technical field of polypropylene plastics. The preparation method is used for solving the technical problems that a plastic product prepared from polypropylene plastic in the prior art is difficult to degrade, and the mechanical property of the polypropylene plastic can be damaged by doping degradable organic components. The rice hull fiber environment-friendly material comprises rice hull fiber composite microspheres, a chlorinated polypropylene graft copolymer and related auxiliaries. The rice hull fiber composite microspheres are prepared by blending acylated rice hull fiber powder and a melt as a core material, wherein the melt is obtained by mixing rosin, silver nitrate and polylactic acid and heating; the chlorinated polypropylene grafted copolymer is obtained by taking chlorinated polypropylene as a main body and initiating grafting of methyl methacrylate and triallyl cyanurate. The rice hull fiber environment-friendly material prepared by the invention has the advantages of good mechanical property, bacteriostasis, flame retardance and degradability.

The present application relates to a kind of powder coating hydroxyalkylamide matting curing agent and its preparation method, the matting curing agent using including citric acid, 2-methyl-1,3-propanediol, dimethylbenzene, anhydrous methanol, N-methyl monoethanolamine, catalyst, nanometer titanium dioxide is reacted to obtain raw materials.In first, citric acid and 2-methyl-1,3-propanediol are grafted to carry out reaction, then the remaining four carboxyl groups of grafting are methyl esterification reaction, obtain methyl esterification product, then with N-methyl monoethanolamine acylation reaction obtains hydroxyalkylamide curing agent;Add nanometer titanium dioxide, fully mix and process to obtain the matting curing agent.The curing agent product functionality is higher, the hardness of coating film after curing is higher, and the boiling water resistance is excellent;And the coating film after curing has obvious matting effect, coating film gloss is basically reached 50-70%, and the decorative property is excellent.

The invention discloses antibacterial and antioxidant bionic hydrogel as well as a preparation method and application thereof. The antibacterial and antioxidant bionic hydrogel disclosed by the invention comprises a hydrogel bracket, wherein the hydrogel bracket is prepared from methacrylated quaternized chitosan, acrylated cyclodextrin, methacrylated gelatin and dopamine grafted methacrylated hyaluronic acid according to the mass ratio of (2 to 4) to (1 to 3) to (5 to 7) to (0.5 to 1.5). The antibacterial and antioxidant bionic hydrogel disclosed by the invention has a porous intercommunication structure, relatively large porosity and water absorption rate, and excellent hydrophilicity, electroactivity, antibacterial property, oxidation resistance and biocompatibility. The antibacterial and antioxidant bionic hydrogel disclosed by the invention can be used as an antibacterial material, especially used as a dressing for treating chronic infection wound surfaces.

The invention belongs to the technical field of asymmetric catalysis, and discloses a chiral phosphine nitrogen-nitrogen tridentate ligand based on a ferrocene skeleton as well as a preparation method and application of the chiral phosphine nitrogen-nitrogen tridentate ligand. The structural formula of the ligand is shown as (I) or an enantiomer (II) of the ligand. The preparation method comprises the steps of acylation reaction, oxazoline ring construction, aldehyde group introduction, reductive amination and the like, and application in asymmetric hydrogenation reaction, such as asymmetric hydrogenation of aryl ketone. The ligand has a plurality of chiral factors, simultaneously has a potential hydrogen bond donor, forms secondary interaction with a substrate in an asymmetric catalytic reaction, can further stabilize a reaction transition state, is an efficient novel chiral P, N, N-ligand, has the advantages of high reaction activity, good stereoselectivity, wide substrate range and the like, and has a wide application prospect. # imgabs0 #

Provided are a new acylated insulin, a pharmaceutical preparation thereof, a pharmaceutical composition thereof containing a long-acting GLP-1 compound, and the medical use of the acylated insulin, the pharmaceutical preparation and the pharmaceutical composition.

The invention discloses a method for preparing 1, 3-propylene glycol by hydrating and hydrogenating acrolein, which comprises the following steps: carrying out hydration reaction by taking an acrolein aqueous solution as a raw material and taking acylated and aminated modified polystyrene resin as a catalyst; carrying out flash evaporation or gas stripping on the product after the reaction to remove acrolein, condensing and recovering the removed acrolein, and carrying out hydrogenation reaction on the acrolein-removed mixed solution serving as a hydrogenation raw material on a metal catalyst; and after the reaction is finished, performing flash evaporation on the product to remove water and light components, and performing vacuum rectification to obtain a high-purity 1, 3-propylene glycol product. According to the method, the modified resin is used for catalyzing the acrolein hydration reaction, the overall yield of the 1, 3-propylene glycol can be increased, the catalyst modification process is simple, the cost is low, the additional value of the final product is high, and the method is suitable for industrial production.

The invention discloses an application of beta-alanine in preparation of a medicine for treating pulmonary arterial hypertension. In-vivo and in-vitro pharmacological experiments prove that beta-alanine can inhibit lactic acid-mediated histone milk acylation modification and hypoxia-induced phenotypic transformation of PASMCs (Polyaspartic Sulfonate Molecules); the hemodynamics and pulmonary artery vascular remodeling of the PAH mouse are improved. The beta-alanine can inhibit phenotypic transformation of PASMCs and reverse pulmonary artery vascular remodeling which is a key pathological change in the pulmonary hypertension generation process, has huge potential in treatment of pulmonary hypertension, and has good application prospects and high clinical application value.