1702 results about "Diazo" patented technology

A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester, carboxylic acid, phosphonic acid, phosphinic acid, sulfonic acid, amide, primary amine, secondary amine, ammonia, tertiary amine, sp2 amine, thiocyanate, cyanamide, oxime, nitrile diazo, organohalide, nitro, s-heterocyclic ring, thiophene, n-heterocyclic ring, pyrrole, o-heterocyclic ring, furan, epoxide, peroxide, hydroxamic acid, imidazole, pyridine and the co-crystal former has at least one functional group selected from amine, amide, pyridine, imidazole, indole, pyrrolidine, carbonyl, carboxyl, hydroxyl, phenol, sulfone, sulfonyl, mercapto and methyl thio, such that the API and co-crystal former are capable of co-crystallizing from a solution phase under crystallization conditions.

The invention provides a black composite reactive dye having three primary color constituents comprising, green disazo dye employing ethylene sulfone series arylamine or aniline derivative as diazo component and H acid as coupling component, one ore more red disazo dyes employing sulfoalkyl J acid or carboxymethyl J acid derivatives as coupling components, one ore more yellow bisazo or polyazo dyes employing sulfochlorinated 3,5-diaminobenzoic acid or sulfoalkyl derivatives as coupling components. The dye can be applied to intermittent and continuous dyeing for cellulose fiber, protein fiber, poly nylon and their fiber mixed fabrics.

Bis-diazo,triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides, and polypeptides. The quencher moieties are non-fluorescent and accept energy from fluorescent reporter labels by any energy-transfer mechanism, such as FRET. Fluorescence quencher compositions are useful in preparing quencher labelled biomolecules for various molecular biology assays based on fluorescence detection.

The invention relates to photochromic transparent organic materials presenting an index of refraction of more than 1.55, which are free of optical distortions and are prepared by radical polymerization of a polymerizable composition comprising: a) 80-95 wt % of at least one monomer represented by the general formula (I): ##STR1## where R=H or CH.sub.3, and m and n are independently 1 or 2; b) 5-20 wt % of at least one aromatic monovinyl monomer represented by the general formula (II): ##STR2## c) an effective quantity of at least one dye that imparts photochromic properties to the material, selected from the groups of spiroxazines, spiropyrans and chromenes; d) an effective quantity of a chain transfer agent; and e) an effective quantity of a radical polymerization initiator, characterized in that the chain transfer agent is a linear alkanethiol and the radical polymerization initiator is a diazo compound.

The invention discloses a sulfur-containing bis-imidazoline type carbon dioxide corrosion inhibitor and a preparation method thereof. The corrosion inhibitor comprises the following components in percentage by weight: 20-50 percent of sulfur-containing bis-imidazoline quaternary ammonium salt, 1-5 percent of nonionic surfactant, 40-70 percent of low molecular alcohol solvent and 5-10 percent of alkynol, wherein a sulfur-containing bis-imidazoline compound has a general formula of a structure which is shown in the specification; the number of carbon atoms in R of the formula is 5 or 8; the nonionic surfactant is fatty alcohol-polyoxyethylene ether or alkylphenol ethoxylate; the low molecular alcohol solvent is methanol, ethanol, isopropanol or ethylene glycol; and the alkynol is propargyl alcohol or hexynol. In the invention, the sulfur-containing bis-imidazoline compound which is generated through dehydration between dicarboxylic acid and polyamine molecule, dehydration reaction in the molecule and further reaction with the sulfur-containing compound is adopted; the molecule contains a plurality of active adsorption centers such as two diazo five-membered heterocyclic rings, a sulfur-containing group and the like; and a formed organic adsorption membrane has better protection effect on carbon steel.

The invention relates to a method for synthesizing a visible-light response type azobenzene polymer. The method comprises the following steps: preparing tetramethoxy dihydroxyazobenzene from 2,6-dimethoxyaniline and 3,5-dimethoxy phenol through diazo-reaction, reacting tetramethoxy dihydroxyazobenzene as a raw material with 6-bromohexane alcohol to prepare tetramethoxy-4-ethanol oxyl azobenzene, grafting azobenzene onto a polypropylene acyl chloride framework through alcoholysis reaction of acyl chloride groups, and converting unreacted acyl chloride groups into carboxyl through hydrolysis, thereby finally obtaining the visible-light response type azobenzene polymer, namely, a 2-(2,6,2',6'-tetramethoxy-4-hexyloxy azobenzene phenoxy) crylic acid ethyl ester acrylic copolymer. The method has the advantages that the method is simple and feasible, the synthesized polymer has visible-light response type azobenzene groups, trans/cis-form conversion is achieved under the radiation of green light (520nm), reverse conversion can be achieved under radiation of blue light (420nm), and compared with conventional azobenzene molecules, the azobenzene polymer has the most remarkable advantage that bidirectional conversion of isomer can be achieved without ultraviolet light.

The invention incorporates new processes for the chemical modification of carbon nanotubes. Such processes involve the derivatization of multi- and single-wall carbon nanotubes, including small diameter (ca. 0.7 nm) single-wall carbon nanotubes, with diazonium species. The method allows the chemical attachment of a variety of organic compounds to the side and ends of carbon nanotubes. These chemically modified nanotubes have applications in polymer composite materials, molecular electronic applications, and-sensor devices. The methods of derivatization include electrochemical induced reactions, thermally induced reactions (via in-situ generation of diazonium compounds or pre-formed diazonium compounds), and photochemically induced reactions. The derivatization causes significant changes in the spectroscopic properties of the nanotubes. The estimated degree of functionality is ca. 1 out of every 20 to 30 carbons in a nanotube bearing a functionality moiety. Such electrochemical reduction processes can be adapted to apply site-selective chemical functionalization of nanotubes. Moreover, when modified with suitable chemical groups, the derivatized nanotubes are chemically compatible with a polymer matrix, allowing transfer of the properties of the nanotubes (such as, mechanical strength or electrical conductivity) to the properties of the composite material as a whole. Furthermore, when modified with suitable chemical groups, the groups can be polymerized to form a polymer that includes carbon nanotubes.

The invention relates to the technical field of trace amount detection, and discloses a method of adopting a fluorescence quenching system to potential fingerprint display. The method is characterized in that potential fingerprint is displayed by utilizing 'turn-on' effect of the fluorescence quenching system to transmit fluorescence once again and includes: firstly, preparing the fluorescence quenching system, wherein the quenching state can be destroyed by fingerprint components; then spraying and painting the fluorescence on various objects with fingerprints, wherein the fingerprint components of chloride ion, amino acid or glucose and the like destroy the quenching state of the fluorescence quenching system to enable the fluorescence to appear to display the fingerprints; taking photos directly through a filter under special light or under natural light. The method is simple and rapid; when fingerprint details are not clear enough, common components like DFO (1.8-diazo-flurene-9-one), IND (indanedione), ninhydrin, silver nitrate and the like are used for continuously displaying the fingerprints, and the method can be further used for 'marking' or 'tracing' the fingerprints.

The invention incorporates new processes for the chemical modification of carbon nanotubes. Such processes involve the derivatization of multi- and single-wall carbon nanotubes, including small diameter (ca. 0.7 nm) single-wall carbon nanotubes, with diazonium species. The method allows the chemical attachment of a variety of organic compounds to the side and ends of carbon nanotubes. These chemically modified nanotubes have applications in polymer composite materials, molecular electronic applications, and sensor devices. The methods of derivatization include electrochemical induced reactions, thermally induced reactions (via in-situ generation of diazonium compounds or pre-formed diazonium compounds), and photochemically induced reactions. The derivatization causes significant changes in the spectroscopic properties of the nanotubes. The estimated degree of functionality is ca. 1 out of every 20 to 30 carbons in a nanotube bearing a functionality moiety. Such electrochemical reduction processes can be adapted to apply site-selective chemical functionalization of nanotubes. Moreover, when modified with suitable chemical groups, the derivatized nanotubes are chemically compatible with a polymer matrix, allowing transfer of the properties of the nanotubes (such as, mechanical strength or electrical conductivity) to the properties of the composite material as a whole. Furthermore, when modified with suitable chemical groups, the groups can be polymerized to form a polymer that includes carbon nanotubes.

Novel addition products of hydroxyl-protecting groups (such as isocyanates) with oxyalkylene-substituted intermediates, such as poly(oxyalkylenated) aniline compounds, for the eventual production of substituted, and substantially pure, colorants, particularly diazo and triphenylmethane derivatives, through the reaction of such intermediates with certain reactants are provided. These new colorants exhibit improved wax and/or oil solubility and high purity, particularly due to the inability of certain impurities to deleteriously react with the protected hydroxyl groups of either the intermediate or the colorant during and/or after formation thereof. A method for producing such novel colorants through utilization of these novel substantially pure colorant intermediates is also provided.

The invention relates to a method for preparing 4-(3-chlorine-4-fluorophenylalanine)-7-methoxy-6-[3-(4-morpholinyl) propoxy] quinazoline (I). The method takes 4-methoxy-2-nitrobenzoic acid as initial material which is subjected to reduction and nitration to obtain 4-methoxy-5-nitryl-2-aminobenzoic acid, is then subjected to cyclization to obtain 7-methoxy-6-nitryl quinazoline-4(3H)-ketone, is again subjected to reduction and diazo reaction hydrolysis to obtain 7-methoxy-6-hydroxy quinazoline-4(3H)-ketone, after etherification reaction is carried out, phosphorus oxychloride is used for preparing 7-methoxy-6-[3-(4-morphjolinyl) propoxy]-4-chloroquinazoline, which is subjected to amination to obtain the compound in the formula (I). The initial material adopted by the preparation method is convenient and accessible, the cost is low, the process route is simple and reasonable, the three wastes produced in the process of preparation generates less pollution, therefore the preparation method can prepare final product with high quality and yield in mass production, and is suitable for industrialized production.

The present invention describes the synthesis of new fluorinated elastomers with very low glass transition temperatures (Tg), a good resistance to bases, gasoline and other carburants and good workability properties, these elastomers contain hexafluoropropene (HFP), perfluoro(4-methyl-3,6-dioxaoct-7-ene) sulfonyl fluoride (PFSO2F), vinylidene fluoride (VDF) and/or at least one fluorinated alkene and/or one vinyl perfluorinated ether. In a precise case, they are prepared by radical polymerisation of HFP and PFSO2F or by radical terpolymerisation HFP, PFSO2F and VDF in the presence of different organic initiator, such as peroxides, peresters or diazo compounds.

The invention relates to a preparation method of panipenem. Firstly, methyl acetoacetate and p-nitrobenzyl alcohol are taken as raw materials to prepare panipenem parent nucleus by six steps of reactions: ester exchange reaction, diazo reaction, enolization reaction, substitution reaction, hydrolysis reaction and ring closing reaction; then, (3R)-3-hydroxy-pyrrolidine hydrochloride, nitrobenzyl chroformate ester are taken as raw materials to prepare panipenem side chain by amidation reaction, sulfonylation reaction, nucleophilic substitution reaction and saponification reaction; finally, the prepared panipenem parent nucleus and panipenem side chain are in butt joint by condensation and are subjected to catalytic hydrolysis and imidization to obtain panipenem. The preparation method of panipenem features simple operation, mild reaction condition, friendly environment, high yield, good product purity, low cost and better industrialized production prospect.

Novel addition products of hydroxyl-protecting groups (such as isocyanates) with oxyalkylene-substituted intermediates, such as poly(oxyalkylenated) aniline compounds, for the eventual production of substituted, and substantially pure, colorants, particularly diazo and triphenylmethane derivatives, through the reaction of such intermediates with certain reactants are provided. These new colorants exhibit improved wax and/or oil solubility and high purity, particularly due to the inability of certain impurities to deleteriously react with the protected hydroxyl groups of either the intermediate or the colorant during and/or after formation thereof. A method for producing such novel colorants through utilization of these novel substantially pure colorant intermediates is also provided.

The invention provides a novel synthesis method for preparing a PARP inhibitor Niraparib. The method comprises the steps that a starting material methyl anthranilate is subjected to diazo coupling, cyclization, amidation, BOC removal and chiral resolution, and then the Niraparib with the purity reaching 99.5% is obtained. The method is simple, convenient and easy to operate suitable for industrial production.

The present invention describes methods for preparing aqueous colored pigment dispersions comprising the step of combining, in any order, a) a colored pigment, b) an azo coupler, c) an aromatic amine, d) a diazotizing agent, and e) an aqueous medium, wherein the aromatic amine comprises as least one ionic group, at least one ionizable group, or a mixture of at least one ionic group and at least one ionizable group. These colored pigment dispersions are particularly useful as an inkjet ink composition. Also disclosed are inkjet ink compositions comprising a) a liquid vehicle, b) a colored pigment, and c) a dispersant having the formula:

D-N═N-AC,

wherein AC is an azo coupling component and D is a diazo component comprising at least one ionic group, at least one ionizable group, or a mixture of at least one ionic group or ionizable group.

The invention provides a method for preparing an azo dye with alkalescent arylamine serving as a diazotization ingredient. The method is characterized in that in a diazotization reaction, ethyl acetate, propyl acetate, butyl acetate, acetone, glycol dimethyl ether or polyethylene glycol 200 is used as a diazotization reaction solvent instead of concentrated sulfuric acid, fluoroboric acid or naphthalene disulfonic acid is used as a diazo salt stabilizer instead of concentrated sulfuric acid, a diazo salt is filtered and separated, filtrate is directly applied to a next diazotization reaction of the alkalescent arylamine, and the diazo salt is applied to a coupling reaction so as to synthesize disperse dyes. Compared with the traditional preparation methods, the method has the advantages that the dosage of the concentrated sulfuric acid can be reduced greatly during the diazotization reaction of the alkalescent arylamine, so that the production cost of the azo dye with the alkalescent arylamine serving as the diazotization ingredient is reduced greatly, the environmental pollution can be reduced from the source, the pollution retreatment of a production end is avoided, and thus, the method has broad application prospects.