1177 results about "Acyl chloride" patented technology

The invention discloses an electrolytic adhesive, an electrolytic cotton adhesive tape and a preparation method of the electrolytic adhesive. The electrolytic cotton adhesive tape comprises the following components in parts by weight: 5-10 parts of 1, 1 '-ferrocene diformyl chloride, 10-15 parts of acrylic acid beta-cyclodextrin ester, 3-8 parts of polyethylene glycol diglycidyl ether, 10-20 parts of ionic liquid, 1.5-3 parts of a cross-linking agent, 10-15 parts of tackifying resin and 0.5-1.5 parts of an initiator, and a polymer matrix comprises an acrylic acid-hydroxypropyl acrylate copolymer and acrylic acid-2-ethylhexyl ester. Comprising an adhesive layer and an adhesive tape base layer, the adhesive layer is prepared from the electrolytic adhesive, and the adhesive tape base layer is prepared from acrylic foam; the obtained electrolytic cotton adhesive tape has high initial adhesion and viscosity strength after power-on and power-off re-adhesion.

The invention relates to the field of packaging materials, and discloses low-temperature heat-sealing water-based coated paper and a preparation method and application thereof.The water-based coated paper comprises a base paper layer and a water-based coating, and the water-based coating comprises water-based ethylene-acrylic acid copolymer emulsion, modified nano-silica, a coalescing agent and water; a cardanol derivative is introduced into the water-based ethylene-acrylic acid copolymer emulsion as a functional component; the cardanol derivative is prepared by reacting epoxidized cardanol with 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide and then grafting with acryloyl chloride. The preparation method comprises the following steps: reacting epoxidized cardanol with 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide; the modified nano silicon dioxide is prepared by mixing aminated nano silicon dioxide and chitosan and adding a cross-linking agent prepared by grafting phytic acid and ethylene glycol diglycidyl ether. The water-based coating paper prepared by the invention overcomes the defects that the existing BOPP film is not environment-friendly, and the conventional coating paper is high in heat sealing temperature and easy to stick; meanwhile, good mechanical properties, water resistance and flame retardance are achieved.

The invention relates to the technical field of polymer photoelectric materials, in particular to a preparation method of a supramolecular gel electrolyte. The method comprises the following steps: esterifying tetraphenylethylene alcohol and methacryloyl chloride to form tetraphenylethylene methacrylate, and performing staged linear heating polymerization on the tetraphenylethylene methacrylate, 3-(methacrylamido) propyl dimethyl 3-thiopropyl ammonium oxide inner salt, acrylic acid, tetraphenylethylene methacrylate and 4-vinylpyridine under the action of ammonium persulfate to obtain a tetraphenylethylene copolymer. And finally, soaking in a lithium chloride aqueous solution to obtain the supramolecular hydrogel electrolyte. The hydrogel obtained by the invention has high mechanical strength and high ionic conductivity, and is suitable for energy storage devices such as flexible supercapacitors and the like.

The invention relates to a bionic strong acid-resistant nanofiltration membrane and a preparation method thereof, and the bionic strong acid-resistant nanofiltration membrane comprises a porous support layer and an active separation layer formed on the surface of the porous support layer, the active separation layer is a polymer network layer formed by carrying out interfacial polymerization reaction on a water-phase solution containing polyamine and an oil-phase solution containing polyacyl chloride on the surface of the porous support layer. The water-phase solution and / or the oil-phase solution also contains a bionic amphiphilic phosphate compound, the bionic amphiphilic phosphate compound participates in interfacial polymerization reaction through an active functional group in a molecular structure of the bionic amphiphilic phosphate compound, and the phosphate structure of the bionic amphiphilic phosphate compound is covalently connected into a skeleton of the polymer network layer. The preparation method has the beneficial effects that the bionic amphiphilic phosphate compound with a hydrophilic phosphate head, a hydrophobic alkyl tail and a reaction site is synthesized, so that the bionic amphiphilic phosphate compound is spontaneously and orderly arranged on a water / oil interface and participates in interfacial polymerization, the film forming uniformity is improved, the pore size distribution is narrowed, and the intelligent response characteristic is given to the film.

The invention belongs to the technical field of membrane separation, and particularly relates to a method for preparing a high-flux hollow fiber nanofiltration membrane based on interfacial polymerization, the obtained membrane and application. The method comprises the following steps: firstly, carrying out pre-adsorption treatment on a polyethersulfone hollow fiber ultrafiltration base membrane through a polyethyleneimine aqueous solution to form a reactive anchoring layer; then sequentially dipping in an aqueous phase solution containing piperazine, sodium phytate and nanoscale cellulose whiskers and an organic phase solution containing trimesoyl chloride and 5-isocyanate isopeptide acyl chloride for interfacial polymerization; and finally, carrying out heat treatment on the obtained primary composite membrane, and completing a gas-phase cross-linking reaction in a glutaraldehyde steam atmosphere. According to the method, the hollow fiber nanofiltration membrane with high flux, high selectivity, excellent chlorine resistance and pollution resistance is successfully prepared through a multi-stage strengthening process, and the hollow fiber nanofiltration membrane is suitable for the fields of drinking water purification, industrial wastewater reuse, material separation and the like.

The invention belongs to the technical field of membrane separation, and particularly relates to a low-pressure high-flux polyamide / polysulfone hollow fiber composite nanofiltration membrane and a preparation method thereof. The preparation method of the composite nanofiltration membrane comprises the following steps: dissolving sulfonated polysulfone, poly (1-vinyl-3-butylimidazole) bromide and polyvinylpyrrolidone to prepare a spinning solution, and spinning to obtain a base membrane; carrying out hydrophilic modification on the base membrane by using 1, 3-propane sultone; then, an aqueous phase solution containing poly (gamma-glutamic acid) and triethylene tetramine and an organic phase solution containing trimesoyl chloride and 3, 5-diaminobenzoic acid are subjected to interfacial polymerization in the inner cavity of the modified base membrane to form a polyamide separation layer; and finally, carrying out heat treatment to obtain the composite nanofiltration membrane. Through the synergistic effect of zwitterionic ionization of the base membrane and biomacromolecule construction of the separation layer, the mass transfer resistance of water is remarkably reduced, unification of high flux and high selectivity is achieved, and good structural stability is achieved.

The synthesis process comprises the following steps: (1) introducing inert gas into a reactor, adding a solvent, a Lewis acid catalyst and diphenyl ether, then dropwise adding an acyl chloride monomer solution, and synthesizing an intermediate M with a short-chain small molecular structure; (2) continuously dropwise adding an acyl chloride monomer solution into the reactor for reaction, and then adding an end-capping reagent for reaction; and (3) quenching, washing and drying the reaction product in the step (2) to obtain the product. Under the condition that only the Lewis acid is used as the catalyst, the one-pot method is adopted for synthesizing PEKK in two steps, side reactions can be reduced, meanwhile, the dosage of the catalyst is reduced, the production cost is reduced, the post-treatment process is simplified, and the obtained polyether ketone ketone is high in molecular weight and good in heat resistance and mechanical performance.

The invention discloses a high-flux high-pollution-resistance nanofiltration membrane as well as a preparation method and application thereof. The scheme is realized by constructing a gradient separation layer compounded by modified MOF and polyamide on a porous support layer; the preparation method comprises the following steps: preparing a water phase from modified MOF grafted with carboxylate radical and sulfonate ion recognition groups on the surface, a polyamine monomer and an ion channel regulator, carrying out interfacial polymerization on the water phase and an oil phase containing a fluorine-containing acyl chloride monomer on the surface of a porous support membrane, and carrying out heat treatment and metal ion post-treatment, the modified MOF in gradient distribution in the nanofiltration membrane can specifically adsorb Ca < 2 + >, Mg < 2 + > and other scaling ions, and scale formation is inhibited from the source; the composite structure simultaneously realizes high flux and high selectivity; the retention rate of the membrane to Na2SO4 under 0.6 MPa is greater than or equal to 99.2%, the retention rate of the membrane to NaCl is less than or equal to 15%, the flux of pure water is greater than or equal to 20 L.m <-2 >. H <-1 >. Bar <-1 >, and the flux attenuation rate is less than or equal to 16.7% after the membrane runs in high-hardness, high-COD and high-salinity wastewater for 120 hours; the scheme is particularly suitable for zero-discharge pretreatment of high-salinity wastewater such as solid waste percolate with the TDS of 5-30% and chemical engineering.

The invention discloses a composite membrane with adsorption separation and catalytic degradation functions as well as a preparation method and application of the composite membrane. The composite membrane is supported by a porous base membrane, a polyamide separation layer formed by reaction of a 3, 4-dihydroxyphenylethylamine and 2, 3-diaminophenol comonomer and acyl chloride is constructed on the surface of the porous base membrane through interfacial polymerization, and FeCo-g-C3N4 nanosheets are anchored in situ; the membrane can efficiently activate peroxymonosulfate (PMS) to generate free radicals under the nearly neutral condition, efficient interception and catalytic degradation of organic pollutants (such as antibiotics) are synchronously achieved, and heavy metal ions (such as Pb < 2 + > and Cd < 2 + >) are adsorbed through a functional monomer structure; the invention provides an interfacial polymerization preparation method of the membrane. The composite membrane breaks through the limitation of'only interception but not degradation 'of a traditional membrane, realizes integration of'separation-adsorption-degradation', can remarkably reduce the volume of concentrated water and reduce the toxicity of the concentrated water, and is suitable for advanced treatment of wastewater containing composite pollutants in the industries of pharmacy, printing and dyeing and the like.

The invention discloses a washable, wear-resistant and uvioresistant polyarylate fiber as well as a preparation method and application of the washable, wear-resistant and uvioresistant polyarylate fiber. The method sequentially comprises the following steps: carrying out surface activation on fibers by adopting a deep eutectic solvent, spraying a TiO2 / organic ultraviolet absorbent UV1130 compound solution to construct an anti-ultraviolet layer, and carrying out interfacial polymerization by utilizing polyethyleneimine and trimesoyl chloride to form a polyamide encapsulation layer. The polyamide film can firmly coat the ultraviolet screening agent and anchor the ultraviolet screening agent on the surface of the fiber, so that the ultraviolet resistance of the polyarylester fiber is remarkably improved, meanwhile, the polyarylester fiber is endowed with excellent durability, the UPF retention rate is still higher than 90% after 10 times of standard washing or 200 times of friction, and the polyarylester fiber has excellent washing resistance and wear resistance. The process is simple, green and efficient, and the prepared composite fiber has wide application prospects in the fields of outdoor protection, intelligent spinning and the like.

The invention discloses cyclodextrin alkyl ether sulfonic acid as well as a preparation method and application thereof, and relates to the technical field of oil and gas field auxiliaries. The preparation method of the cyclodextrin alkyl ether sulfonic acid comprises the following steps: adding hydroxyl alkyl sulfonic acid into dichloromethane, adding alkali and a sulfonyl chloride reagent, and reacting for 3-5 hours to obtain sulfonate; the preparation method comprises the following steps: adding sulfonate into iodide, adding acetone, reacting for 5-8 hours, and removing excessive iodide after the reaction is finished, so as to obtain iodo-hydrocarbyl sulfonic acid; the preparation method comprises the following steps: dissolving cyclodextrin in tetrahydrofuran, cooling to 0 DEG C, adding alkali under the protection of nitrogen, reacting for 0.5-2 hours, then adding iodo-alkyl sulfonic acid, reacting for 30-60 hours at room temperature, cooling to 0 DEG C, and carrying out reduced pressure distillation to obtain cyclodextrin alkyl ether sulfonic acid; the cyclodextrin alkyl ether sulfonic acid prepared by the invention is used as a cosolvent of the powder resistance-reducing agent, can effectively prevent aggregation among molecules of the powder resistance-reducing agent, improves the dispersity, reduces agglomeration and precipitation phenomena, and meanwhile, can avoid pipeline blockage in a conveying process.

The invention relates to the field of separation and purification, in particular to an anti-pollution nanofiltration membrane for magnesium-lithium separation, the anti-pollution nanofiltration membrane comprises a base membrane and a functional layer, and the functional layer is prepared from the following raw materials in parts by weight: a water phase: 1.5-2.5 parts of piperazine, 0.1-1 part of lauryl sodium sulfate, 0.5-2 parts of glycerol, 1-2 parts of triethylamine, 0.6-2 parts of ionic polymer, and the balance of water for supplementing the total amount of the water phase to 100 parts; the ionic polymer comprises at least one of sulfobetaine metacrylic acid ester, sulfobetaine and carboxyl betaine metacrylic acid ester; and an oil phase: 0.1-1 part of trimesoyl chloride, and the total amount of the oil phase is supplemented to 100 parts by normal hexane or isoparaffin. The ionic polymer is added, and a compact hydration layer is formed on the surface of the membrane by using a betaine group of the ionic polymer, so that the membrane pollution probability is reduced, and common inorganic scaling and organic pollution in the high-salt brine are remarkably inhibited; in addition, the ionic polymer enables the membrane surface to have strong negative electricity, and the magnesium ion rejection rate is improved; and the ionic polymer can also reduce the lithium ion transmission energy barrier and reduce the rejection rate.

The invention relates to the technical field of polyamide nanofiltration membranes, in particular to an acid and alkali resistant high-strength nanofiltration membrane and a preparation method thereof. The problem that the strength and the acid and alkali resistance of a polyamide nanofiltration membrane in the prior art cannot be considered at the same time is solved. The base membrane material of the polyamide nanofiltration membrane is modified polyethersulfone and is obtained by chemically bonding a carbon nanotube subjected to double surface modification by titanium dioxide sol-gel and a KH550 coupling agent in a polyester non-woven fabric, and the modulus of the material is improved by utilizing an inorganic-organic hybrid network; the functional layer of the polyamide nanofiltration membrane is made of modified polyamide, and the modified polyamide functional layer is formed by forming a polyamide matrix through polymerization reaction of 2, 2 '-disulfonic acid-4, 4'-diaminobiphenyl, piperazine and trimesoyl chloride and introducing 4-amino-2, 2, 6, 7-tetramethyl-1, 3-pentanediol at the same time. And the chemical resistance is improved by a free radical capturing group generated by 2, 2, 6, 6-tetramethylpiperidine and octa-isobutyl cage type silsesquioxane.

The invention relates to the technical field of epoxy resin materials, and discloses an epoxy resin material based on two-dimensional aromatic polyamide and a preparation method thereof.The preparation method comprises the specific preparation steps that firstly, melamine reacts with 1, 3, 5-trimesoyl chloride, washing, centrifuging and drying are performed to obtain two-dimensional aromatic polyamide, and the two-dimensional aromatic polyamide is ground into nano powder; secondly, adding the nano powder according to 0.5% of the mass of the amine curing agent, and performing ultrasonic dispersion to form a homogeneous-phase enhanced curing agent; and finally, blending the bisphenol A resin E51, the perfluorooctanoyl chloride modified melamine and the amine curing agent containing the two-dimensional aromatic polyamide to obtain the epoxy resin material. The two-dimensional aromatic polyamide epoxy resin material disclosed by the invention has relatively good mechanical property and waterproof property.

The invention relates to the field of sheath materials, and discloses an anti-aging sheath material for an electronic wire and a preparation method thereof, the sheath material comprises low density polyethylene, an ethylene-vinyl acetate copolymer, an ethylene-octene copolymer, ethylene propylene diene monomer, a triazine ring derivative, ammonium polyphosphate, modified nano silicon dioxide and an auxiliary agent; according to the triazine ring derivative, N-butyl-2, 2, 6, 6-tetramethyl-4-piperidylamine reacts with cyanuric chloride to prepare a triazine ring monosubstituent, hydrazine hydrochloride is used as a bridging agent to react with the triazine ring monosubstituent, and the triazine ring derivative and piperazine are polymerized to prepare the triazine ring derivative. The modified nano silicon dioxide is prepared by enabling 3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionyl chloride and 4-propenyloxy-2-hydroxybenzophenone to react, and carrying out free radical polymerization on the reaction product on the surface of the nano silicon dioxide. The synergistic effect of mechanical property, thermo-oxidative aging resistance, ultraviolet aging resistance and flame retardant property is realized.

The invention belongs to the technical field of membrane separation, and particularly relates to a polyamide composite membrane containing amino-carboxyl bifunctional COFs as well as a preparation method and application of the polyamide composite membrane. The preparation method comprises the following steps: by taking 1, 3, 5-tri (4-aminophenyl) benzene, 4, 4 '-diaminobiphenyl-2, 2'-dicarboxylic acid and 1, 3, 5-trialdehyde phloroglucinol as monomers, carrying out solvothermal reaction to prepare a bifunctional COFs material rich in amino groups and carboxyl groups at the same time; the preparation method comprises the following steps: dispersing a COFs material in a water phase containing polyamine, and carrying out interfacial polymerization on the water phase and an oil phase containing polyacyl chloride to prepare the composite membrane. COFs are firmly anchored in a polyamide network through a covalent reaction between amino and an acyl chloride monomer, so that the problems that the COFs are easy to fall off and non-uniform in dispersion are solved; the water flux is improved by regular pore channels of COFs, the membrane is endowed with strong hydrophilicity and electronegativity by carboxyl, the desalination rate and the pollution resistance are remarkably enhanced, and the COFs-based composite membrane has a wide application prospect in seawater desalination and high-salinity wastewater treatment.

The invention relates to the field of pipes, and discloses a high-strength CPVC pipe and a preparation method thereof.The pipe comprises CPVC resin, modified multi-walled carbon nanotubes, modified nano silicon dioxide and auxiliaries; the modified multi-walled carbon nanotubes are prepared by grafting phosphorus-containing cardanol derivative based benzoxazine and oxidized multi-walled carbon nanotubes; phosphorus-containing cardanol derivative benzoxazine reacts with 1, 5-naphthylenediamine to prepare an aldehyde cardanol intermediate, the aldehyde cardanol intermediate is prepared by reacting paraformaldehyde with hydrogenated cardanol, the obtained cardanol derivative and DOPO are subjected to addition, and then the obtained phosphorus-containing cardanol derivative reacts with paraformaldehyde and 3-aminopropyltriethoxysilane to prepare the flame retardant. The modified nano silicon dioxide is prepared by introducing polyethylene glycol into the surface of isocyanated nano silicon dioxide and grafting with 3, 5-bis (tert-butyl)-4-hydroxybenzene propionyl chloride, and the pipe prepared by the invention is high in tensile strength and impact strength and has good long-acting oxidation resistance, high temperature resistance and flame retardance.

The application belongs to the field of fine chemical industry and environmental protection, and particularly relates to a method for preparing metal triflate by using high gravity reaction. The method comprises the following steps: 1, using trifluoromethylsulfonyl chloride and anhydrous HF gas as raw materials to generate trifluoromethylsulfonyl fluoride gas; 2, performing gas-liquid contact reaction of the trifluoromethylsulfonyl fluoride gas with an alkali metal solution to obtain a mixed solution; 3, performing solid-liquid separation on the mixed solution by using a filter press, and the liquid phase is a triflate salt solution; 4, drying the triflate salt solution by using a spray dryer to obtain a solid-phase product triflate salt. The method uses trifluoromethylsulfonyl chloride and anhydrous HF as raw materials to replace triflic acid in the traditional method, and utilizes high gravity reaction, so that the production cost is greatly reduced. The process is simple, the obtained product triflate metal salt has low impurity content, is superior to the industry standard, the process is zero emission, and has good economic value and social value.

The invention belongs to the technical field of membrane separation, and particularly relates to a polyamide composite membrane, a preparation method thereof and a water purification method. Piperazine is dissolved in deionized water, a PIP solution is prepared, and the concentration of piperazine in the PIP solution is 0.05-2 wt%; fumaryl chloride is dissolved in a first organic solvent, an FC / organic solution is prepared, and the concentration of fumaryl chloride in the FC / organic solution is 0.2 wt%; soaking a basement membrane in the PIP solution, enabling the basement membrane to fully adsorb PIP, removing a redundant water phase on the surface of the basement membrane, forming a uniform water phase environment, and obtaining the treated basement membrane; and transferring the FC / organic solution to the surface of the treated basement membrane, carrying out polymerization reaction on the FC and the PIP, washing with a second organic solvent to terminate the polymerization reaction, and drying to obtain the polyamide composite membrane. According to the preparation method, construction of the polyamide layer can be rapidly completed at normal temperature and normal pressure, controllable adjustment of the shape of the polyamide layer can be achieved, and the prepared membrane is stable in structure and good in repeatability.

The invention provides an acid-resistant and anti-pollution composite nanofiltration membrane as well as a preparation method and application thereof, and relates to the technical field of membrane materials. The preparation method comprises the following steps: soaking the surface of a support membrane with a mixed solution I; the mixed solution I is prepared from doxycycline, 4-aminopyridine and deionized water; pouring an oil phase solution into the surface of the soaked support membrane to carry out interfacial polymerization reaction; the oil phase solution is composed of 1, 3-benzene disulfonyl chloride and cyclohexane; and carrying out heat treatment on the support membrane after the interfacial polymerization reaction to obtain the acid-resistant anti-pollution composite nanofiltration membrane. According to the prepared composite nanofiltration membrane, doxycycline is selected as a water-phase monomer for the first time, meanwhile, 1, 3-benzene disulfonyl chloride is selected as an oil-phase monomer, 4-aminopyridine is selected as an additive, and the prepared composite nanofiltration membrane not only has acid resistance and pollution resistance, but also has high permeation flux and high separation performance.

The application discloses a preparation method of perfluoroalkyl aryl sulfide, and a structural formula of the perfluoroalkyl aryl sulfide is shown as formula (I); the method comprises the following steps: firstly, obtaining corresponding aryl sulphenyl chloride by chlorination of thiophenol; under the condition that fluoride and crown ether exist, obtaining perfluoro-1,1-dimethylbutyl negative ion by addition of D-2 ‑ And the aryl sulphenyl chloride added is subjected to a nucleophilic substitution reaction to synthesize a product (1,1,1,3,3,4,4,5,5,5-decafluoro-2-trifluoromethylpent-2-yl)(aryl)sulfide. The application adopts a reaction strategy of efficient coupling of thiophenol and perfluoroalkyl, and can be used for preparing various fluorine-containing benzene sulfide compounds.

The invention relates to a preparation method of composite porous carbon beneficial to silicon deposition. Comprising the following steps: S1, carrying out surface oxidation and acylating chlorination treatment on porous carbon fine powder to obtain acylating chlorinated porous carbon fine powder; s2, adding the acylating chlorination porous carbon fine powder and an amino compound into a solvent to obtain amide modified porous carbon fine powder; s3, soaking the amide-modified porous carbon fine powder in a catalyst aqueous solution to obtain catalyst-loaded porous carbon; s4, mixing the porous carbon loaded with the catalyst with a carbon source precursor solution, carrying out hydrothermal reaction, and freeze-drying to obtain a porous carbon composite precursor; and S5, carbonizing and activating the porous carbon composite carbon precursor to obtain the composite porous carbon beneficial to silicon deposition. The composite porous carbon prepared by the invention is beneficial to more and uniform deposition of silicon in pores of the core porous carbon fine powder, and has low powder resistivity.

The invention belongs to the field of organic synthesis, and particularly relates to a method for preparing trimesoyl chloride in an immobilized catalysis mode. An immobilized catalyst is used as an acyl chloride reaction catalyst, thionyl chloride and benzene tricarboxylic acid are used as raw materials, and direct boiling reflux reaction is performed under the condition of not introducing other solvents; after the reaction is finished, filtering out the catalyst, and terminating the reaction; and then carrying out reduced pressure distillation to remove excessive reactant thionyl chloride, and then carrying out vacuum distillation to obtain the product trimesoyl chloride. By adopting the immobilized catalyst and taking the raw material as the reaction solvent, the method has the characteristics of mild reaction, simple process, high reaction speed, high product purity, high product yield and the like. And the immobilized catalyst and the reactant thionyl chloride can be recycled, so that the cost is saved, the reaction tail gas is easy to treat, the environmental pollution is not easily caused, and the method is suitable for industrial production. The final product is trimesoyl chloride, the purity can reach 99.2% or above, and the yield reaches 92% or above.

The present application relates to a kind of five-ring thiazole indole ketone piperazine amide derivatives and purposes thereof.The derivatives take ethyl cyanoacetate as starting material, generate hydroxylamine compound (A) under the action of sodium nitrite and phosphoric acid;Obtain 2-amino ethyl cyanoacetate (B) by reduction, in turn with acetic anhydride, lawson reagent is reacted, and 5-amino-4-carboxylate thiazole compound (D) is obtained;After bromination by NBS, under the catalysis of phosphorus oxychloride, react with tetrahydropyridine indole ketone, generate 2-bromo-6,7-dihydrothiazolo [5'',4'':4',5'] pyrimido [1',2':1,2] pyrindo [3,4-b] indole-4 (12H) -ketone (F), again under alkaline condition, first with Boc piperazine, then by Boc treatment and obtain compound (H);Finally, react with acyl chloride, and 28 different substitution structures of five-ring thiazole indole ketone piperazine amide compound (I1-I28) are synthesized.The 28 compounds are tested on three kinds of cancer cells, and the results show that: 28 compounds have significant inhibitory activity on Hela cervical cancer cells, HT-29 human colon cancer cells and HGC-27 human gastric cancer cells.

The invention discloses a 4-BrPA / beta-CD supramolecular photosensitizer as well as a preparation method and application thereof, and belongs to the field of biomedical materials. According to the method, beta-cyclodextrin is used as a subject, 4-bromophthalic anhydride is used as an object, and the water-soluble photosensitizer is constructed through a chemically modified supramolecular assembly strategy. The preparation method comprises the following specific steps: reacting beta-cyclodextrin with paratoluensulfonyl chloride to obtain mono-(6-O-paratoluensulfonyl)-beta-cyclodextrin; then carrying out a reaction with ethidene diamine to obtain mono-(6-ethidene diamine-6-deoxy)-beta-cyclodextrin; then reacting with 4-bromophthalic anhydride in N, N-dimethylformamide, and precipitating and purifying through ethyl acetate to obtain a crude product; and finally, carrying out ultrasonic treatment, centrifugal separation and freeze drying to obtain a pure product. The prepared 4-BrPA / beta-CD supramolecular photosensitizer is excellent in water solubility, has at least 7 excitation centers in a visible light region of 400-520 nm, correspondingly generates at least 7 emission centers in a range of 500-780 nm, has a maximum excitation wavelength of about 460 + / -10 nm and a maximum emission wavelength of about 620 + / -10 nm, has an extremely wide visible light response characteristic, and can be used for antibacterial photodynamic therapy.

Provided are a polyamide membrane that maintains a regular pore structure even in an organic solvent, has long-term stability, has excellent selectivity, and has a high separation efficiency, as well as a manufacturing method therefor. This polyamide membrane, which is formed by polymerizing an aminoporphyrin monomer and an acid chloride monomer, has a regular pore structure and a crystalline structure. The porphyrin is expanded in a horizontal direction of the membrane due to the side functional groups of the quadrilateral, and forms pore channels in a vertical direction due to the macrocycle (macrocycle compound). Additionally, the porphyrin is characterized by being protonated. Due to the porphyrin being protonated, deviation occurs in accordance with the degree of protonation of the porphyrin, the sliding distance of a stack of the aminoporphyrin monomer is adjusted, a change occurs in the vertical pore channels, and the pore size is adjusted.

The application discloses a triazolinone compound, and a preparation method thereof. The structural general formula (I) of the triazolinone compound is as follows: the preparation method is to perform esterification or amidation reaction on a compound containing a hydroxyl group or an amino group as raw material in a solvent and 2-chloro-3-(2-chloro-5-(4-difluoromethyl-3-methyl-5-oxo-1,2,4-triazol-1-yl)-4-fluorophenyl) propionyl chloride prepared through acyl chloride reaction, so as to obtain a triazolinone structure-containing herbicidal compound. The preparation method is simple, the reaction process is short, and the triazolinone structure-containing herbicidal compound has the advantages of novel structure, high herbicidal activity and the like.

The invention belongs to the technical field of lipase immobilization, and particularly relates to immobilized lipase and a preparation method thereof. The preparation method comprises the following two steps: (I) preparation of activated amino type silica gel resin: mixing amino type silica gel resin, a nonionic surfactant 1308 and deionized water according to a mass ratio of (1000-1100): (2000-2200): (5-8), stirring at 1-5 DEG C for 10-15 minutes, adding cyanuric chloride, dripping a 30-35 wt% sodium hydroxide solution, reacting, and centrifuging; (II) preparation of immobilized lipase: mixing the activated resin, a surfactant, deionized water and a lipase solution, dropwise adding an alkaline solution at 40-45 DEG C under the condition that the pH is 5.0-5.5, and centrifuging, washing and drying after reaction. The obtained immobilized lipase is firm in covalent binding, the enzyme activity is greater than or equal to 50% after the immobilized lipase is repeatedly used for 6 times, the acid-base tolerance and the storage stability are excellent, and the immobilized lipase is suitable for industrial catalysis in multiple industries.

The invention relates to a pinoxaden preparation method, which comprises: S1, carrying out a cyclization reaction on hydrazine hydrate and a compound represented by a formula (I) to generate an intermediate 1; s2, reacting the intermediate 1 with a compound as shown in a formula (II) in the presence of alkali to generate an intermediate 2; s3, enabling the intermediate 2 to react with 2, 6-diethyl-4-methyl bromobenzene under the action of a catalyst to generate an intermediate 3; s4, the intermediate 3 and pivaloyl chloride react in the presence of alkali, pinoxaden is obtained, the structural formula of the intermediate 1 shown in the formula (I) is shown in the description, the structural formula of the intermediate 2 shown in the formula (II) is shown in the description, and the structural formula of the intermediate 3 shown in the description is shown in the description.

The invention discloses a high-activity BODIPY type photosensitizer targeting double organelles as well as a preparation method and application of the high-activity BODIPY type photosensitizer, and relates to the technical field of medical photosensitizers. The high-activity BODIPY type photosensitizer is prepared by the following steps: reacting 2, 4-dimethyl pyrrole with 4-bromobutyryl chloride to obtain a compound Br-BY containing carboxyl, then reacting with morpholine to obtain a morpholine substituted compound Mor-BY, and finally reacting with N-iodosuccinimide (NIS) to obtain a single atom I substituted BODIPY compound Mor-IBY, namely the target photosensitizer. The photosensitizer prepared by the invention can target mitochondria and lysosome in cancer cells at the same time, and can be excited by visible light; the compound has good water solubility, can generate a large amount of reactive oxygen species (ROS) under irradiation of green light (520 nm), shows excellent photodynamic activity to tumor cells, and has low toxicity to normal cells.