627 results about "Acryloyl chloride" patented technology

The invention discloses a photo-curing monomer with ortho-phenolic hydroxyl strucutre, a preparation method and bond thereof. In the formula I monomer, the compound which has crylic acid at two ends or crylic acid double bond at one end and methylacrylic acid double bond at the other end is added to the amidogen of dopamine and derivant thereof through a Michael addition method to form corresponding secondary amine or tertiary amine. In the formula II monomer, the double bond is introduced by (methyl) acrylic anhydride, (methyl) crylic acid and (methyl) acryloyl chloride. The photopolymerization bond comprises the following components by weight percent: 20 to 99.9 percent of the compound with the ortho-phenolic hydroxyl structure, 0 to 70 percent of activated thinner and/or solvent, 0.1 to 10 percent of evocating agent and 0 to 60 percent of natural macromolecule or modified outcome thereof. The bond can be bonded in dry state and wet state, is a quick and long lasting bond, realizes the organic bond of biological bond and photopolymerization, has the advantages of low manufacture cost, simple and convenient operation and high productivity and has extensive application foreground in the biological bond field.

The invention discloses a preparation method of anti-bacterial hydrogel dressing. The method comprises the following steps: 1) dissolving dihydroxy-terminated polyethylene glycol in tetrahydrofuran, adding acryloyl chloride to react at room temperature under the protection of nitrogen, treating the obtained reaction product through filtrating, evaporating, washing and concentrating to obtain polyethyleneglycol diacrylate crosslinking agent; 2) using ZnO nanoparticles containing Ag<+> to prepare 15-30wt% of nanometer water solution, then dissolving natural high molecular material in the nanometer water solution to obtain natural high molecular water solution containing nano-Ag; 3) mixing acrylamide, polyethyleneglycol and natural high molecular water solution containing nano-Ag, placing themixture at room temperature under the irradiation of <60>Co source for crosslinking and obtaining the anti-bacterial hydrogel dressing, the molar ratio of Ag to Zn is 1:4. The anti-bacterial hydrogeldressing prepared by the method is a kind of porous reticular dressing with antibacterial property and hydrating capacity.

The present invention relates to a polymerizable macromolecule photoinitiator and a preparation method thereof. The preparation method comprises: adding 4-hydroxybenzophenone and a formaldehyde solution to a three-necked flask filled with an alkali adopted as a catalyst, carrying out heating stirring to a temperature of 95 DEG C, and carrying out a reaction for 2 hours; heating to a temperature of 150 DEG C, carrying out a reaction, and carrying out a reduced pressure suction filtration reaction for 20 minutes; cooling to a temperature of 105 DEG C after completing the reaction, and collecting the product; pouring the product into water to carry out precipitation, and carrying out suction filtration to obtain a benzophenone-containing macromolecule photoinitiator; dissolving the benzophenone-containing macromolecule photoinitiator in an organic solvent, and simultaneously adding the benzophenone-containing macromolecule photoinitiator and a tertiary amine to the three-necked flask to carry out stirring; dissolving acryloyl chloride in an organic solvent, and slowly adding the organic solvent containing the acryloyl chloride to the mixing solution in a dropwise manner, wherein thereaction temperature is 0-5 DEG C; after completing the addition, stirring for 3 hours at a room temperature, and standing overnight; carrying out suction filtration, washing and drying on the resulting solution; and carrying out rotary evaporation to remove the solvent to obtain the polymerizable macromolecule photoinitiator. The photoinitiator prepared by the preparation method of the present invention has characteristics of large molecular weight, relatively small mobility, self-polymerization, and the like.

The invention discloses a side-chain liquid crystal polymer with aggregation-induced emission property and a preparation method thereof. A substituted cyano-distyrene compound is generated by using a substituent-containing para benzaldehyde derivative and hydroxybenzyl cyanide through Knoevenagel reaction, so that, on one hand, the substituted cyano-distyrene compound can react with polymerizable double bond-containing acids such as saturated dihalide, methacrylic acid or acrylic acid in sequence to generate a polymerizable monomer and a side-chain liquid crystal polymer with a flexible spacer is obtained through free radical polymerization; and on the other hand, the substituted cyano-distyrene compound can directly react with polymerizable double bond-containing acyl chloride such as methacryloyl chloride or acryloyl chloride to generate the polymerizable monomer and a side-chain liquid crystal polymer free of the flexible spacer is obtained through free radical polymerization. A fluorescent chromogenic group and a liquid crystal unit are combined into one; the method is simple in synthesis and easy to purify, and the obtained polymer has an obvious aggregation-induced emission effect, has excellent liquid crystal property and has a good application prospect.

The invention relates to a synthetic method of an anti-tumor medicine, namely N-[2-[[2-(dimethylamino) ethyl] methyl amino]-4-methoxy-5-[[4-(1-methyl-1H-indole-3-yl)-2-pyrimidyl] amino] phenyl]-2-acrylamide (AZD9291) and a key intermediate of the anti-tumor medicine. The synthetic method comprises the following steps: performing Boc acid anhydride protection on 4-fluoro-2-methoxy-5-nitroaniline to obtain 4-fluoro-2-methoxy-5-nitroanilino tert-butyl formate, then reacting with N,N,N'-trimethylethylenediamine to obtain 4-(N,N,N'-trimethylethylenediamino)-2-methoxy-5-nitroanilino tert-butyl formate, then reducing to obtain 2-(N,N,N'-trimethylethylenediamino)-4-methoxy-5-tert-butyl carbamate phenylamine, then completely reacting with acryloyl chloride and directly removing a Boc protecting group to obtain 2-methoxy-4-N,N,N'-trimethylethylenediamino-5-acrylamido phenylamine, and finally reacting with 3-(2-chloropyrimidine-4-yl)-1-methylindole to obtain AZD9291. A process disclosed by the invention is simple in step, relatively high in yield, mild in reaction condition and easy for realization of industrial production.

The invention relates to an electrophoresis particle of polymer dye (pigment) for electronic ink and a preparation method thereof, and belongs to technology of electrophoresis particle preparation. The electrophoresis particle uses dye as an initial raw material, and is prepared according to the following proportion that: the mass ratio of the dye to acryloyl chloride is 1:1-10; the mass ratio of the dye to styrene is 1:1-20; the mass ratio of the dye to divinylbenzene is 1:0.5-10; and the mass ratio of the dye to an initiator AIBN is 1:0.01-0.05. The preparation method comprises the following steps: carrying out functionalized modification on dye acidylation by acryloyl chloride in methylene dichloride to lead the dye to carry a polymerizable functional group; then, leading the dye to perform a polymerization reaction with styrene in ethanol for 4 to 12 hours by taking AIBN as the initiator and the divinylbenzene as a cross-linking agent to prepare the particle with particle diameter of between 200 and 300nm. The electrophoresis particle and the preparation method have the advantages of simple process, accessible raw materials, even particle diameter of the prepared colorful electrophoresis particle and good degree of sphericity. The electrophoresis particle of the organic polymer dye (pigment) not only maintains the advantages of bright color and proper density of the organic dye, but also overcomes the defects uneven shape of the organic dye particle, poor movement effect in disperse liquid under the action of an electric field.

The invention belongs to the technical field of high polymer materials, and relates to a sensible hydrogel, in particular to a hydrogel with pH sensibility and temperature sensibility and a preparation method thereof. The preparation method comprises the following steps: synthesizing hydroxy propyl cellulose and acrylic acid or acryloyl chloride into acrylic acid cellulose ester and copolymerizing the prepared acrylic acid cellulose ester and acrylic acid monomer to form the hydrogel. The hydrogel comprises hydroxy propyl cellulose chain segment with pH sensibility and temperature sensibility and acrylic acid chain segment with pH sensibility, and meanwhile, the hydrogel has pH sensibility, temperature sensibility and degradability and flexible responsiveness to the pH, can rapidly generate volume expansion or contraction, and has favorable mechanical property, good intellectuality and easy and feasible synthetic method, and the temperature sensibility is influenced by the pH value of the solution.

The invention discloses a phosphorous and nitrogenous UV-cured flame retardant and a preparation method thereof. According to the invention, phosphorus and nitrogen compound precursor with high phosphorus content is synthesized by using raw materials of alcamines compound, aldehydes compound, and dialkyl phosphite through Kabachnik-Fields reaction; a light-cured monomer containing phosphorus and nitrogen elements is prepared through substitution/esterification reaction of the precursor with (methyl) acryloyl chloride or (methyl) propenoic acid by utilizing active hydroxy of the precursor; the monomer is used as reaction type flame retardant to be applied to light-cured resin matrix, and can curve rapidly with matrix under UV lighting to form a flame-retarded light-cured material which not only has good flame retardant property, but also can reduce the transfer and loss of the flame retardant in the using process. Compared with a conventional additive flame retardant, the compatibility of the flame retardant and the macromolecule matrix is also increased, and the duration of the flame retardant property of the material can be guaranteed.

A mono-component hydrogen-abstraction initiating agent is prepared by reacting dihydroxy-alkyl-benzophenone, dicarboxyl-alkyl-benzophenone or bisamine-alkyl-benzophenone with acryloyl chloride, inducing into acrylate double bond and Michael reacting it with secondary amine or primary amine. It's simple, cheap and efficient, has excellent solubility and mobility. It can be used for coating, binder, printing ink, photo-etching and biological materials.

The invention provides a preparation method of a phase change monomer with double-bond end groups, which comprises the following steps of: in an ice water bath, dissolving PEG (Polyethane Glycol MW2000-10000) in dichloromethane, and then adding an acid binding agent (triethylamine or N,N-dimethylacetylamide) and acryloyl chloride; reacting at a temperature of 25-35 DEG C for 4-8h under the protection of nitrogen; adding a precipitant (n-hexane or diethyl ether) in reacting liquid in the ice water bath, settling for 10-15 minutes and leaching to obtain a finished product, wherein the molar ratio of the PEG to the acryloyl chloride is 1:(1-3), the molar ratio of the PEG to the acid binding agent is 1:(1-3), and the molar ratio of the PEG to the dichloromethane is 1:(0.312-0.546). The monomer has high activity and is easy to carry out copolymerization or grafting reaction with other monomers or polymers to prepare solid-solid phase change materials. The monomer has higher phase change enthalpy (163.21J/g), proper phase change temperature (46.53 DEG C) and higher thermal tolerance (320 DEG C). The preparation technology is simple, and the production cost is low.

The invention relates to a preparation method of a pectinate high-polymer phase-change energy storage material, which comprises the following steps: (1) in an ice water bath, after dissolving polyethylene glycol monomethyl ether in dichloromethane, adding an acid binding agent and acryloyl chloride, heating to 35-40 DEG C, and reacting in a nitrogen atmosphere for 6-8 hours; (2) in the ice water bath, adding a precipitant into the reaction solution, standing for 10-15 minutes, and carrying out vacuum filtration to obtain the acrylate polyethylene glycol monoester; and (3) dissolving the acrylate polyethylene glycol monoester and acrylamide monomers in a solvent, adding an initiator, heating to 70-85 DEG C, and reacting for 30-120 minutes to obtain the phase-change energy storage material with pectinate molecular chain shape. The phase-change material prepared by the method provided by the invention can flow in the form of a melt in the hot working process, and the pectinate molecular chain shape can reduce the plastification action on the base; and the invention has the advantages of simple preparation technique and low production cost.

The invention relates to an anti-shearing polymer and a preparation method thereof. The polymer is a copolymer composed of acrylic amide, sodium acrylate, hydrophobic monomer dimethyl allyl-N-alkyl ammonium chloride and a functionalized framework monomer. The average molecular weight of the copolymer is 6 million. The preparation method comprises the following steps of: (1) respectively dissolving a polyamide-amide macromolecular framework monomer and maleic anhydride (or acryloyl chloride and acrylic anhydride) into dimethyl sulfoxide; slowly dropwise adding a framework monomer solution intoa maleic anhydride solution; introducing nitrogen and placing the system into an ice salt bath; when the pH (Potential of Hydrogen) value of a reaction solution is 4-5, stopping dropwise adding the framework monomer solution; and utilizing chloroform to repeatedly precipitate to obtain the functionalized framework monomer; and (2) carrying out free radical water solution polymerization on the acrylic amide, acrylic acid, the hydrophobic monomer and the functionalized framework monomer. The anti-shearing polymer and the preparation method thereof have the advantages of reliable principle and convenience for operation; and the synthesized polymer still has good tackifying capability under high-temperature, high-salinity and strong shearing effects.

The invention relates to a high-molecular pH probe containing a rhodamine lactam group thereof. A synthetic method comprises the following steps: carrying out a reaction on rhodamine with hydroxyl on a site 2 and ethidene diamine to form lactam; carrying out a reaction on lactam and a matter containing an acryloyl chloride group to obtain a monomer containing the rhodamine group; finally, copolymerizing with the matter containing the acryloyl chloride group to synthesize the high-molecular pH fluorescent probe which has fluorescent response to H' specificity and can enter into viable cells.

The invention discloses loaded alpha-palladium diimine and a method for preparing hyperbranched polyethylene by catalyzing with same. The loaded alpha-palladium diimine is obtained by loading a loaded alpha-palladium diimine complex on an acryloyl chloride-modified magnesium chloride carrier and performing cationization, wherein the magnesium chloride carrier is a magnesium chloride/ethanol compound; and the alpha-palladium diimine complex has a structure shown as a formula (I). In the invention, the alpha-palladium diimine complex is loaded on the acryloyl chloride-modified magnesium chloride/alcohol compound carrier under the actin of a chemical bond, so that the influence of a functional group on the carrier surface on the active center is lowered, and the catalytic activity is higher than those of corresponding homogeneous phase catalysts; and moreover, the carrier and the catalyst have high bonding strength under the action of a valence bond, so that the active center can be effectively prevented from falling easily in the polymerizing process. The loaded alpha-palladium diimine can be taken as a catalyst for use in preparation of hyperbranched polyethylene, and has high catalyst activity; and the formula (I) is shown in the specifications.

The present invention discloses a kind of 1,3-aryl substituted pyrazoline whose delta-position contains ester group and its liquid phase synthesis method. In the organic solvent, in the presence of alkali the substituted acryloyl chlorine is coupled on the soluble resin, under the action of organic alkali the isoequivalent aromatic aldehyde and aromatic hydrazine hydrochloride are mixed to obtain the correspondent hydrazone, then the substituted acrylic ester loaded by soluble resin and oxidant are added, and the above-mentioned materials are undergone the ring-forming reaction of one-pot method so as to obtain the 1,3-aryl substituted pyrazoline whose delta-position contains ester group which is loaded on the resin. In the alcohol solvent and under the catalysis of correspondent alcohol sodium the pyrazoline can be separated from soluble resin so as to obtain the invented product with high yield rate and high purity. It can be developed into medicine, pesticide and light sensitive material.

The invention relates to a polymeric photoinitiator and a preparation method thereof. The structural formula of the polymeric photoinitiator is shown in the specification. The method comprises the following steps: reacting a hydroxyl-containing benzophenone derivative, paraformaldehyde and diglycolamine which serve as raw materials to synthesize red liquid (BZOH) through a Mannich reaction; and reacting BZOH with acryloyl chloride to generate the polymeric photoinitiator (BZOA). The macromolecule initiator simultaneously contains benzophenone and tertiary amine, and the efficiency of generating reactive species through photosensitive decomposition is improved. Because the initiator contains the benzoxazine structure and unsaturated double bonds, the compatibility with an initiating system is improved, the surface migration of the photoinitiator is reduced, and the photoinitiator can serve as a monomer for synthesizing macromolecules and is widely applied to the fields of ultraviolet light polymerization and the like. R1 and R2 are mutually independent -H, -CH3, -OH or -CH2Cl, wherein at least one substituent group exists at the ortho-position in the hydroxyl-containing benzophenone derivative.

The present invention relates to fluorine and silicon containing copolymer resin and paint. The composition includes fluorinated compound in 1-30 wt%, silane 2-8 wt% and alkenyl containing compound 62-97 wt%. The fluorinated compound is acrylic fluoro resin obtained through the reaction of fluorinated alcohol and acryloyl chloride or acrylic anhydride; the silane is one containing alkenyl group or containing carbon functional group with oxygen atom; and the alkenyl containing compound methacrylic acid, methacrylate, vinyl carboxylate and alkenyl containing benzene compound. The present invention has the advantages of fluorinated acrylic acid copolymer and silicon containing acrylate copolymer paint and the paint is excellent single component paint.

The invention discloses an antibiotic environmentally-friendly film and a production method thereof. The antibiotic environmentally-friendly film sequentially comprises a PET layer, an antibiotic layer, a PE layer and a sterilization coating layer from inside to outside, wherein the antibiotic layer is produced from polylactic acid, hydroxypropyl acrylate, acryloyl chloride, trifluoropropylmethyldichlorosilane, vinyltriisopropoxysilane, hydroxypropyl methyl cellulose, chitosan, eugenol, polyvinyl alcohol, an emulsifier, an initiator and deionized water, and the sterilization coating layer is produced from ethanol, polyethylene glycol, deionized water, cinnamaldehyde, beta-cyclodextrin, a titanate coupling agent, nanometer titanium dioxide, organosilicone resin, a dispersant and an antifoaming agent. The antibiotic environmentally-friendly film produced in the invention has the advantages of good sterilization and antivirus effects, good durability, long service life and no pollution to environment.

The invention discloses a preparation method of low molecular weight polyacrylic ester acrylic ester for photo-curing, belonging to the field of photo-curing low polymers. The lower polymer has the advantages of low molecular weight, low dispersibility, low viscosity, uniform structure and excellent property after being cured and can be used for photo-curing main body resin. The low polymer is synthesized by a two-step method and consists of a main chain and a branch chain, wherein the main chain is a pure carbon-carbon bond and is prepared by acrylic ester double-bond copolymerization. A polymerization monomer consists of (methyl) alkyl acrylate and functional monomers. The branch chain is prepared by a condensation reaction of functional groups; and a reaction product of a (methyl) acrylic ester copolymer in the first step carries the functional groups capable of further reaction, and functional monomers with light reactivity are grafted in the reaction product, wherein the functional monomers can be (methyl) acrylic acid, acryloyl chloride and the like. The invention realizes the preparation of the lower polymers with low molecular weight by using methods of adding a chain transfer agent and controlling the mixture ratio of the monomers and the dosage of initiators, is simple and convenient to operate and easy to industrialized production and has broad application prospect.

The invention discloses a modified hydrogel material used for 3D printing and application of the same to drug loading, belonging to the technical field of 3D printing materials. The modified hydrogel material is prepared through the following steps: adding a hydrogel material, acryloyl chloride and triethylamine into a solvent, carrying out a reaction in an ice bath for 12 h and then carrying out a reaction at normal temperature for 12 h; and washing a reaction product with a saturated sodium bicarbonate solution and then carrying out rotary evaporation so as to obtain the modified hydrogel material. The modified hydrogel is of a long-chain structure and has an active chemical group at its tail end; and as a photopolymerization initiator is added into the aqueous solution of the modified hydrogel, a crosslinking reaction occurs under the illumination of light with a wavelength of 365 nm, so rapid shaping of the material is realized. The modified hydrogel material prepared by using 3D printing technology and used for drug loading can be subjected to injection and printing at normal temperature without extra high-temperature apparatuses, low-temperature apparatuses or the like; and the material is easy to shape, fast in gelating speed, excellent in mechanical properties and beneficial for loading and effective release of different medicine molecules.

The invention discloses biodegradable temperature response hydrogel and a preparation method thereof. The method comprises the following steps of: (1) reacting terminal hydroxyl group of polycaprolactone dihydric alcohol with crylic acid (or methacrylic acid) to prepare polycaprolactone macromolecule cross-linking agent; (2) reacting singe terminal hydroxyl group of polyethylene glycol monomethylether and acryloyl chloride (or methacryloylchloride) to prepare a polyethylene glycol monomethyl ether macromolecule monomer; and (3) copolymerizing the polycaprolactone macromolecule cross-linking agent, the polyethylene glycol monomethyl ether macromolecule monomer and N-isopropylamide according to a certain ratio to obtain the biodegradable temperature response hydrogel. Compared with the traditional hydrogel, the hydrogel disclosed by the invention has the advantages of being rapid in response speed, good in mechanical strength, biodegradable and good in biocompatibility; therefore, the hydrogel is hopeful to be applied in the drug slow release field.