Modified hydrogel material used for 3D printing and application of same to drug loading

A technology of 3D printing and gel materials, applied in the field of modified hydrogel materials and their application in drug loading, can solve the shortage of 3D printing materials, achieve good biocompatibility, expand the scope of use, The effect of improving mechanical properties

Inactive Publication Date: 2016-10-12
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Modified hydrogel material used for 3D printing and application of same to drug loading
  • Modified hydrogel material used for 3D printing and application of same to drug loading
  • Modified hydrogel material used for 3D printing and application of same to drug loading

Examples

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Embodiment 1

[0042] Example 1: Preparation of 3D printed drug-loaded hydrogel material

[0043] (1) Preparation of modified hydrogel material: 12.6g of Pluronic F-127 was dissolved in 100mL of a mixed solution with a volume ratio of dichloromethane: acetone = 1:1, and 3mL of acryloyl chloride and 3mL of Tris were added dropwise in an ice bath. Ethylamine, react in ice bath for 12h, and react at room temperature for 12h. After the reaction, washed with saturated sodium bicarbonate solution, rotary evaporated and vacuum dried at 40° C. for 24 hours to obtain modified F-127 (12 g).

[0044] (2) Preparation of drug-loaded hydrogel material for 3D printing: Dissolve 11 g of modified F-127 in 100 mL of pure water, add 1 g of camptothecin, stir at room temperature for 24 hours, then add 0.5 g of 2,2-di Methoxy-2-phenylethanone was mixed uniformly to obtain a printing liquid.

[0045] (3) 3D printing: Use CAD to design a cube with a size of 20*20*2mm (length, width and height) and load it into t...

Embodiment 2

[0046] Example 2: Preparation of 3D printed drug-loaded hydrogel materials

[0047] In Example 1, "dissolve 12 g of modified F-127 in 100 mL of water" is changed to "dissolve 5.3 g of modified F-127 in 100 mL of water", and the rest are the same as in Example 1. At this time, the mass fraction of modified F-127 in the printed hydrogel material is 5%. The elastic modulus was tested under different ultraviolet light irradiation times, and the results were as follows: figure 1 shown, corresponding to figure 1 5% F-127 in.

Embodiment 3

[0048] Example 3: Preparation of 3D printed drug-loaded hydrogel material

[0049] In Example 1, "dissolve 12g of modified F-127 in 100mL of water" is changed to "dissolve 18g of modified F-127 in 100mL of water", and the rest are the same as in Example 1, and the printed The mass fraction of modified F-127 in the hydrogel material is 15%. The elastic modulus was tested under different ultraviolet light irradiation times, and the results were as follows: figure 1 shown, corresponding to figure 1 15% F-127 in.

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Abstract

The invention discloses a modified hydrogel material used for 3D printing and application of the same to drug loading, belonging to the technical field of 3D printing materials. The modified hydrogel material is prepared through the following steps: adding a hydrogel material, acryloyl chloride and triethylamine into a solvent, carrying out a reaction in an ice bath for 12 h and then carrying out a reaction at normal temperature for 12 h; and washing a reaction product with a saturated sodium bicarbonate solution and then carrying out rotary evaporation so as to obtain the modified hydrogel material. The modified hydrogel is of a long-chain structure and has an active chemical group at its tail end; and as a photopolymerization initiator is added into the aqueous solution of the modified hydrogel, a crosslinking reaction occurs under the illumination of light with a wavelength of 365 nm, so rapid shaping of the material is realized. The modified hydrogel material prepared by using 3D printing technology and used for drug loading can be subjected to injection and printing at normal temperature without extra high-temperature apparatuses, low-temperature apparatuses or the like; and the material is easy to shape, fast in gelating speed, excellent in mechanical properties and beneficial for loading and effective release of different medicine molecules.

Description

technical field [0001] The invention belongs to the technical field of three-dimensional printing materials, and in particular relates to a modified hydrogel material for 3D printing and its application in drug loading. Background technique [0002] In the traditional processing industry, object molding is mainly divided into subtractive molding, pressure molding, additive molding, and growth molding. . 3D printing technology is a combination of computer data model and rapid automatic prototyping system, which processes and superimposes liquid, powder, sheet and other materials layer by layer without additional molds, and finally prints into the desired shape. In the past few decades, 3D printing technology has been successfully applied in clinical fields, including neurosurgery, orthopedics, and stomatology. At present, the main application of 3D printing is in auxiliary medical treatment, such as 3D printing patient models, 3D printing personalized surgical guides and ot...

Claims

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Application Information

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IPC IPC(8): C08F283/06C08F220/02C08F287/00B33Y70/00A61K47/34A61K9/06A61K31/513A61K31/4745
CPCA61K9/06A61K31/345A61K31/4745A61K31/513A61K47/34B33Y70/00C08F283/06C08F287/00C08F220/02
Inventor 薛巍张洁玲马栋王永周张奕左琴华李承花
Owner JINAN UNIVERSITY
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