The invention relates to the technical field of
drug carriers, and discloses a
sodium alginate
microsphere and a preparation method and application thereof.The preparation method comprises the steps that a suspension containing
cellulose and
sodium alginate is added into an
oil phase to be emulsified, a water-in-
oil emulsion is formed, then a cross-linking agent is stirred and mixed to be subjected to a cross-linking reaction with the water-in-
oil emulsion, original microspheres are obtained, and the
sodium alginate
microsphere is prepared. Finally, the original microspheres are treated with
etching liquid, and the
sodium alginate microspheres are obtained. According to the water-in-
oil emulsion,
cellulose cannot be dissolved in water and oil, so that
cellulose in the water-in-oil
emulsion is dispersed in liquid drops in a suspended state; in the cross-linking reaction process, cellulose does not participate in cross-linking and is embedded into the interior and the outer surface of a
sodium alginate skeleton formed by the cross-linking reaction; after the original microspheres are treated with an
etching solution, cellulose is degraded to different degrees, so that pore channels are reserved in the microspheres, the finally prepared
sodium alginate microspheres are rich in pore channels, large in specific surface area and small in density, and the
drug loading rate of the
sodium alginate microspheres is increased.