3063 results about "Boronic acid" patented technology

The present invention provides a composition comprising the product prepared by hearing together: (a) a dispersant; and (b) a 1,3-dicarboxylic acid or 1,4-dicarboxylic acid of an aromatic compound, or a reactive equivalent thereof; and at least one of: (c) 2,5-dimercapto-1,3,4-thiadiazole or a hydrocarbyl-substituted 2,5-dimercapto-1,3,4-thiadiazole, or an oligomer thereof; (d) a borating agent; and (e) a phosphorus acid compound, or a reactive equivalent thereof, said heating being sufficient to provide a reaction product of (a), (b), and (c), (d), or (e), which is soluble in an oil of lubricating viscosity. The invention further provides a use for the composition.

The present invention concerns an electrode carrying immobilized redox enzymes such that electric charge can flow between an electron mediator group to the enzyme cofactor by the use of boronic acid or a boronic acid derivative that acts as a linker moiety between the cofactor and the electron mediator group. The invention also concerns devices and systems that make use of the electrode of the invention, such as biosensors and fuel cells, the electrode being one of the components thereof.

The room temperature ionic liquid containing unsaturated double bond has the general expressino of A+B-, where A+ contains R1 being hydroxyl with 1-4 carbon atoms and R2 containing 2-20 carbon atoms and at least one double bond; and B- is one of anions, including chlorate radical, bromate radical, iodate radical, acetate radical, sulfate radical, nitrate radical, tetrafluorobromate radical, etc. Its preparation is to mixture and react olefin halide R1X and N-alkyl imidazole to obtain ionic liquid dialkyl imidazolium halide. The present invention also relates to the application of the ionic liquid in dissolving cellulose and preparing cellulose derivative.

The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

A device and method for non-invasive real-time testing of blood sugar levels in a diabetic patient. Specifically, this invention is directed to an optical device comprising a contact lens having a glucose-sensing optical pattern imprinted, marked, coated or otherwise disposed on or incorporated within the contact lens. The indicator pattern is further comprised of a glucose-sensing coating containing a boronic acid derivative, which reacts in the presence of glucose to create a readable pattern, which can then be correlated to a pre-determined or pre-calibrated blood glucose level. A polarized light source is one method that may be used to read the indicator pattern. The invention is also directed to methods for quantifying blood glucose levels using the inventive optical device and manufacturing methods for disposing the glucose-sensing coating onto, or incorporating it into, the contact lens material.

A pharmaceutically acceptable base addition salt of an organoboronic acid of formula (XXX):

wherein: P is hydrogen or an amino-group protecting moiety; R is hydrogen or alkyl; A is 0, 1 or 2;

• • R¹, R² and R³ are independently hydrogen, alkyl, cycloalkyl, aryl or —CH₂—R⁵;
  • R⁵, in each instance, is one of aryl, aralkyl, alkaryl, cycloalkyl, heterocyclyl, heteroaryl, or —W—R⁶, where W is a chalcogen and R⁶ is alkyl; and
  • where the ring portion of any of said aryl, aralkyl, alkaryl, cycloalkyl, heterocyclyl, or heteroaryl in R¹, R², R³ or R⁵ can be optionally substituted.

Disclosed are methods and devices for detection of ion migration and binding, utilizing a nanopipette adapted for use in an electrochemical sensing circuit. The nanopipette may be functionalized on its interior bore with metal chelators for binding and sensing metal ions or other specific binding molecules such as boronic acid for binding and sensing glucose. Such a functionalized nanopipette is comprised in an electrical sensor that detects when the nanopipette selectively and reversibly binds ions or small molecules. Also disclosed is a nanoreactor, comprising a nanopipette, for controlling precipitation in aqueous solutions by voltage-directed ion migration, wherein ions may be directed out of the interior bore by a repulsing charge in the bore.

The spectroscopic and photophysical properties of fluorescent probes comprising donor-acceptor derivatives comprising the boric acid group or a derivative of boric acid, B(OH)3 (or borate ion, BO(OH)2<-1>), arsenious acid, H3 AsO3 (or arsenite ion, H2AsO3<-1>), telluric acid, H6TeO6 (or tellurate ion, H5 TeO6<-1>) or germanic acid, Ge(OH)6 (or germanate ion, GeO(OH)3<-1>) are described. Method of using said probes are also provided.

Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a brush copolymer comprising (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer.

The present invention provides a method for detecting an analyte, comprising providing a sensor comprising a substrate coated with a free electron metal, a matrix layer disposed on the free electron metal, the matrix layer comprising an organic compound, wherein the organic compound has a boronic acid complexing moiety and, a boronic acid moiety complexed to the boronic acid complexing moiety; and contacting the sensor with the analyte to elicit a response; and measuring the response thereby detecting the analyte.

The present invention discloses a water-based cutting fluid for vermicular cast iron processing, and a dilution solution thereof. The water based cutting fluid comprises 3-10% of an anti-rust additive, 4-10% of fatty acid amide, 2-3% of organic amine, 3-10% of long-chain fatty acid, 2-5% of fatty alcohol polyoxyethylene ether, 5-8% of petroleum sodium sulfonate, 1-5% of a coupling agent, 10-15% of an extreme pressure additive, 15-20% of a synthetic ester, 1-2% of a sterilization agent, 0.5-1.0% of an anti-forming agent, and 32-45% of water, wherein the anti-rust additive is a boric acid anti-rust additive and dicarboxylic acid, and the coupling agent is a fatty alcohol and/or aliphatic ether. The water-based cutting fluid of the present invention has characteristics of good lubrication performance, good cooling performance, good anti-rust property, no chlorine, diamine, nitrite and other nitro compounds, no environmental pollution, no irritating odor, easy cutting, easy powder settlement, and effective cutter service life prolonging.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents. Other embodiments relate to pharmaceutical compositions containing boronic acid derivatives and additional excipient such as meglumine.

Polymeric compounds of formula I comprising boronic acid are provided. These polymeric compounds are prepared either by grafting boronic acid containing compounds (e.g. 4-carboxyphenylboronic acid) to hydrolysed poly(N-vinylformamide) or hydrolysing copolymer(s) obtained by copolymerizing vinyl group containing boronic acid monomers (e.g. -vinylphenyl boronic acid) and N-vinylformamide. These polymeric compounds are used in increasing the wet strength of paper in paper-making processes. Formula (I).

The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.

Thienothiophenes compositions comprising a C_3-8 secondary or tertiary alkyl group are disclosed. The thienothiophenes may berepresented by the formula:

where R is C_3-8 secondary or tertiary alkyl, e.g., isopropyl, tert-butyl, tert-pentyl, isopentyl, and 2-ethylhexyl, X and X′ are independently selected from the group consisting of H, halogen atoms (e.g., F, Cl, Br, and I), MgCl, MgBr, Mgl, Sn(R′)₃, (where R′ is C_1-6 alkyl or —OC_1-6 alkyl), boronic acid, boronic ester, —CH═CHR″ (where R″ is H or C_1-6 alkyl), —OC_1-6 alkyl, —COOC_1-6 alkyl, —S—COR′″, —COR′″ (where R′″ is H or C_1-6 alkyl), —C≡CH, and polymerizable aromatic rings such as phenyl, naphthalene, pyrrole, dithiophene, thienothiophene, thiophene and so forth.

A multi-layer structure comprising a layer of an ethylene-vinyl alcohol copolymer (A), a layer of a carboxylic acid-modified polyolefin (B), a layer of a thermoplastic resin (C) having a solubility parameter of 11 or less, and a layer of a resin composition (E), wherein the resin composition (E) comprises an ethylene-vinyl alcohol copolymer (A), a carboxylic acid-modified polyolefin (B), a thermoplastic resin (C) and a thermoplastic resin (D) having at least one functional group selected from the group consisting of a boronic acid group and boron-containing groups capable of being converted into a boronic acid group in the presence of water, and the layer of an ethylene-vinyl alcohol copolymer (A) is laminated with the layer of a thermoplastic resin (C) or the layer of a resin composition (E) through the layer of a carboxylic acid-modified polyolefin (B). This provides a multi-layer structure which allows effective reuse of regrind and which is excellent in impact resistance and gas barrier properties.

Polymeric nanoaggregate drug-delivery compositions including boron-containing copolymers are described. The drug-delivery compositions may further include a therapeutic agent comprising a nucleic acid, a polynucletide, a peptide, a polypeptide, a protein, a pharmaceutical or any combinations thereof. Methods for making the polymeric nanoaggregate compositions including at least one therapeutic agent (for example, insulin) as well as methods for administration of these compositions to mammals are also set forth. The disclosure also describes compositions and methods for controlled drug delivery. Further, polymeric nanoaggregate boron-containing compositions including insulin and methods for monitoring and regulating blood glucose levels of a mammal are also described. The disclosure also describes methods for treatment and/or control of diabetes mellitus by administering polymeric nanoaggregate boron-containing compositions including insulin to a mammal in need.

The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

The present invention is related to glucose sensors that are capable of detecting the concentration or level of glucose in a solution or fluid having either low or high ionic strength. The glucose sensors of the present invention comprise a polymerized crystalline colloidal array (PCCA) and a molecular recognition component capable of responding to glucose. The molecular recognition component may be a boronic acid, such as a phenylboronic acid, glucose oxidase, a combination of phenylboronic acid and poly(ethylene)glycol or crown ether, or another component capable of detecting glucose in various fluids and solutions. The glucose sensors of the present invention may be useful in the development of noninvasive or minimally invasive in vivo glucose sensors for patients having diabetes mellitus.

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.