210 results about "Sulfonyl fluoride" patented technology

The invention discloses a non-aqueous electrolyte and a lithium ion battery containing the non-aqueous electrolyte. The non-aqueous electrolyte comprises a lithium salt, a non-aqueous organic solvent and an additive, wherein the additive comprises a benzenesulfonyl fluoride compound as shown in a structural formula I and a carbonate bisulfate compound as shown in a structural formula II. According to the non-aqueous electrolyte disclosed by the invention, the benzenesulfonyl fluoride compound and the polyol carbonate bisulfate compound are used as additives, and the benzenesulfonyl fluoride compound and the polyol carbonate bisulfate compound are matched for use, so that the ion transmission rate can be increased, the high-temperature cycle performance of the lithium ion battery is improved, the internal resistance is reduced, and the high-temperature storage performance of the lithium ion battery is improved. # imgabs0 #

The invention belongs to the technical field of electrolyte additives, and discloses a thiophenesulfonyl electrolyte additive, an electrolyte and a lithium ion battery, the thiophenesulfonyl electrolyte additive has the following structural formula: # imgabs0 #, in which R1 is selected from F, H or sulfonyl fluoride; r2 is selected from F, H or sulfonyl fluoride; r3 is selected from F, H or sulfonyl fluoride; and R1, R2 and R3 at least comprise one fluorine atom. Through the synergistic effect of the thiophenesulfonyl electrolyte additive and the FEC, the positive and negative electrode film-forming impedance can be effectively improved, the side reaction is inhibited, and the high-temperature and high-voltage cycle performance of the battery is improved.

The application provides a preparation method of sodium bisfluorosulfonimide, which comprises the following steps: (1) sulfuryl fluoride and hexamethylsilazane are reacted in an inert atmosphere to obtain a crude product, and the crude product is subjected to gas phase separation to obtain bisfluorosulfonimide; (2) the bisfluorosulfonimide obtained in the step (1) is reacted with sodium fluoride to obtain the sodium bisfluorosulfonimide. The sulfuryl fluoride and the hexamethylsilazane are used as raw materials to prepare the bisfluorosulfonimide by one-step method, the cost is reduced, and the production safety is improved, then the sodium bisfluorosulfonimide is prepared by ion exchange reaction of the bisfluorosulfonimide and sodium fluoride, the three wastes and solvent use are reduced, the impurities are reduced, and the production safety and product quality are improved.

The invention relates to the technical field of chemical synthesis, and discloses a preparation method of anhydrous N, N-dimethyl amino sulfuryl fluoride, which comprises the following steps: (1) introducing sulfuryl fluoride gas into a dimethylamine organic solution to carry out nucleophilic substitution reaction, and then adding triethylamine to obtain a mixed solution containing N, N-dimethyl amino sulfuryl fluoride; and (2) sequentially carrying out normal-pressure rectification and reduced-pressure rectification on the mixed solution containing the N, N-dimethyl amino sulfonyl fluoride to obtain the N, N-dimethyl amino sulfonyl fluoride. According to the method, water is not introduced in the whole process, the risk of water residue is avoided, and the prepared product is high in yield and purity.

The invention relates to the technical field of preparation of polyurethane plastic materials, in particular to an environment-friendly high-elasticity foaming material as well as a preparation method and application thereof. The preparation method of the foaming material comprises the following steps: perfluorooctyl sulfonyl fluoride and diaminopropyl polydimethylsiloxane are subjected to a reaction, and fluorine-containing polydimethylsiloxane is obtained; the preparation method comprises the following steps: reacting 3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propanohydrazide with terephthalic diisothiocyanate to obtain isothiocyanate modified hindered phenol; the isothiocyanate modified hindered phenol reacts with primary amine at the terminal position of a fluorine-containing polydimethylsiloxane molecule through an isothiocyanate group to obtain an intermediate, and the intermediate is subjected to a desulfurization reaction to obtain a modifier; the preparation method comprises the following steps: reacting diisocyanate with polyether polyol, polyester polyol and natural polyol to obtain a component A, and stirring and mixing polyether polyol, a bio-based chain extender, a modifier, a catalyst and a foaming agent to obtain a component B; stirring and mixing the component A and the component B, and foaming to obtain the environment-friendly high-elasticity foaming material.

The invention discloses a high-oxygen-permeability ionomer with a large steric hindrance group as well as a preparation method and application of the high-oxygen-permeability ionomer, and belongs to the technical field of fuel cells. The preparation method comprises the following steps: (1) in a solution environment, carrying out nucleophilic substitution reaction on perfluorosulfonyl fluoride resin and an aminobenzene sulfonic acid compound under the action of an acid-binding agent, and recovering to obtain an ionomer after the reaction is finished; (2) washing the ionomer in a strong alkali solution, and filtering to obtain a product; and (3) carrying out protonation treatment on the product, and recovering to obtain the high-oxygen-permeability ionomer with the large steric hindrance group after the protonation treatment is completed. The method has the advantages that the process is convenient, post-treatment is convenient, batch preparation can be achieved, and the method is suitable for industrial production. The high-oxygen-permeability ionomer with the large steric hindrance group is used for a proton exchange membrane fuel cell, the peak power density is optimized, the mass transfer performance is improved, and the high-oxygen-permeability ionomer shows excellent cell output performance especially in a large-current-density area and has a wide application prospect.

The invention provides perfluorosulfonic acid resin and a polymerization method. The polymerization method comprises the following steps: mixing perfluoromethyl vinyl ether, perfluorosulfonyl fluoride vinyl ether and a fluorine-containing solvent to obtain a mixed solution; and adding an initiator into the mixed solution, introducing a tetrafluoroethylene monomer, carrying out a copolymerization reaction, carrying out solid-liquid separation, and carrying out transformation and drying to obtain the perfluorinated sulfonic acid resin. The perfluoromethyl vinyl ether monomer is introduced into a copolymerization system, so that the rigidity of a polymer main chain is effectively reduced, and the flexibility and low-temperature mechanical strength of the resin are enhanced; the crystallinity is effectively reduced, the Tg is adjusted, and the catalyst is suitable for low-temperature proton exchange membrane fuel cells and other application scenes; the introduction of perfluoromethyl vinyl ether improves the compatibility between the main chain and the sulfonyl fluoride-containing side chain, and is beneficial to the formation of a clearer and more continuous hydrophilic / hydrophobic microphase separation structure. A stable proton conduction network is facilitated, and the electrochemical performance of the resin under harsh working conditions is remarkably improved.

The invention provides an electrolyte and a lithium ion battery, the electrolyte comprises an organic solvent, a lithium salt electrolyte and an additive, the additive comprises a nitrile compound containing a benzene ring structure and a carbon-carbon double bond, and a nitrile compound containing triphenylamine and a sulfonyl fluoride group; the electrolyte comprises the following components in percentage by weight: 0.3%-1.2% of nitrile compounds containing benzene ring structures and carbon-carbon double bonds, and 0.3%-1.2% of nitrile compounds containing triphenylamine and sulfonyl fluoride groups. Based on the electrolyte provided by the invention, the problems of poor high-temperature cycle performance and high-temperature storage performance of the lithium ion battery in the prior art are solved.

The invention discloses a solvent-free preparation method of 2-thiophenesulfonyl fluoride, which comprises the following steps: carrying out nucleophilic fluorination reaction on 2-thiophenesulfonyl chloride under the action of a fluorination reagent at 0-70 DEG C to generate a 2-thiophenesulfonyl fluoride crude product, distilling under a vacuum condition, and separating the product at 30-100 DEG C to obtain colorless and transparent high-purity 2-thiophenesulfonyl fluoride. The method provided by the invention has the advantages of easily available raw materials, simple synthesis process, high product purity, high yield, large material contact area by adopting a solvent-free method, and reaction time saving; the method does not need solvent recycling and post-treatment links, is energy-saving and environment-friendly, saves the production cost, achieves the purpose of clean production, and has a wide application prospect.

The invention belongs to the technical field of synthesis of organic intermediates, and particularly relates to a synthesis method and a synthesis device of benzenesulfonyl fluoride. The synthesis method of the benzenesulfonyl fluoride comprises the following steps: firstly, adding hydrogen fluoride and sulfuryl chloride into a premixer, enabling the hydrogen fluoride and the sulfuryl chloride to sequentially pass through tubular reactors a, b and c, enabling the hydrogen fluoride and the sulfuryl chloride to enter a terminal reaction kettle for mixing reaction, controlling gas-liquid two-phase mixing reaction through the terminal reaction kettle and a vertical condenser a to prepare sulfuryl fluoride chloride, then mixing the sulfuryl fluoride chloride, benzene and a catalyst, and finally adding the benzenesulfonyl fluoride into the premixer to obtain the benzenesulfonyl fluoride. The method comprises the following steps: adding benzenesulfonyl fluoride into a sulfonation reaction kettle for reaction, controlling the sulfonation reaction through the sulfonation reaction kettle and a vertical filler b to obtain a mixed reaction solution, finally distilling the mixed reaction solution, and collecting fractions to obtain benzenesulfonyl fluoride. The synthesis method of the benzenesulfonyl fluoride provided by the invention is low in reaction condition requirement, stable, easy to control, low in unit consumption and easy in subsequent treatment, and the prepared benzenesulfonyl fluoride is high in yield and high in purity. The invention also provides a synthesis device adopted by the synthesis method of benzenesulfonyl fluoride.

The invention relates to the technical field of new functions of environmental nanomaterials, and discloses a composite material as well as a preparation method and application thereof. The composite material comprises ordered mesoporous alumina of which the surface is modified with amino groups, and perfluorooctyl sulfonyl fluoride grafted by the amino groups. According to the composite material disclosed by the invention, amino and hyperbranched perfluorooctyl functional groups enriched on the surface of a matrix are used for adsorbing and anchoring perfluorooctyl sulfonate ions in a foam extinguishing agent and fire-fighting wastewater; and the pH value of the solution is flexibly regulated and controlled, so that the amino functional group is protonated, and a targeting site is provided for adsorption of perfluorooctyl sulfonic acid anions.

The invention provides a non-aqueous electrolyte and a secondary battery containing the non-aqueous electrolyte. The non-aqueous electrolyte comprises an electrolyte salt, a non-aqueous organic solvent and an additive. The additive comprises a sulfonyl pyridinium inner salt compound and a sulfonyl fluoride compound. The structural formula of the sulfonyl pyridinium inner salt compound is as shown in the structural formula I. The structural formula of the fluorosulfonyl compound is shown as a structural formula II or a structural formula III. Wherein R < 1 > to R < 6 > are independently selected from hydrogen atoms and substituted or unsubstituted alkyl groups of C1 to C3, R < 7 > to R < 8 > are independently selected from hydrogen atoms and substituted or unsubstituted alkyl groups of C1 to C3, and R < 9 > is selected from alkylene groups of C1 to C10. The additive of the non-aqueous electrolyte contains a sulfonyl pyridinium inner salt compound and a sulfonyl fluoride compound, so that the high-temperature cycle performance can be improved while the high-temperature storage performance of the battery is improved. # imgabs0 #

The invention discloses a preparation method of bis (trifluoromethylsulfonyl) imide salt, and belongs to the technical field of metal ion battery electrolyte materials, and the preparation method comprises the following steps: mixing trifluoromethylsulfonyl fluoride and organic amine alkali to obtain a mixed solution A; dropwise adding the mixed solution A into a reaction kettle filled with ammonia gas, and completely reacting to generate bis (trifluoromethanesulfonyl) imide quaternary ammonium salt; carrying out reduced pressure distillation on the reaction product to obtain pure bis (trifluoromethanesulfonyl) imide quaternary ammonium salt; the preparation method comprises the following steps: mixing bis (trifluoromethylsulfonyl) imide triethylamine salt and metal salt according to a molar ratio of 1: (1-3), and completely reacting in an organic solvent to generate bis (trifluoromethylsulfonyl) imide salt; and filtering the reaction liquid, and carrying out reduced pressure distillation to obtain the final product bis (trifluoromethylsulfonyl) imide salt. The preparation method provided by the invention has the characteristics of simple process, high yield and high product purity, and solves the problems of complex process, low yield, low product purity and the like in the existing preparation method.

The application belongs to the field of fine chemical industry and environmental protection, and particularly relates to a method for preparing metal triflate by using high gravity reaction. The method comprises the following steps: 1, using trifluoromethylsulfonyl chloride and anhydrous HF gas as raw materials to generate trifluoromethylsulfonyl fluoride gas; 2, performing gas-liquid contact reaction of the trifluoromethylsulfonyl fluoride gas with an alkali metal solution to obtain a mixed solution; 3, performing solid-liquid separation on the mixed solution by using a filter press, and the liquid phase is a triflate salt solution; 4, drying the triflate salt solution by using a spray dryer to obtain a solid-phase product triflate salt. The method uses trifluoromethylsulfonyl chloride and anhydrous HF as raw materials to replace triflic acid in the traditional method, and utilizes high gravity reaction, so that the production cost is greatly reduced. The process is simple, the obtained product triflate metal salt has low impurity content, is superior to the industry standard, the process is zero emission, and has good economic value and social value.

The invention discloses a compound and a synthesis method thereof, the synthesis method of the compound takes heptafluorobutanol as a raw material, and the compound is synthesized through five-step reaction, and the synthesis method comprises the following synthesis steps: S1, taking heptafluorobutanol as the raw material, and carrying out esterification reaction with benzene sulfonyl chloride to obtain an intermediate 1; s2, carrying out substitution reaction on the intermediate 1 to obtain an intermediate 2; s3, carrying out substitution reaction on the intermediate 2 to obtain an intermediate 3; s4, adding inorganic acid into the intermediate 3, dropwise adding a NaClO solution, and reacting to obtain an intermediate 4; and S5, carrying out fluorination reaction on the intermediate 4 to obtain the compound heptafluorobutanol sulfonyl fluoride. According to the synthesis method of the compound, heptafluorobutanol is used as a starting raw material, heptafluorobutanol sulfonyl fluoride is obtained through five-step reaction, use of a dangerous material hydrogen fluoride is avoided, special equipment is not needed, production is safer, and industrial production is more facilitated.

The invention discloses a preparation method of 2-oxo-4-phenyl oxazine sulfonyl fluoride, and belongs to the field of organic chemical synthesis. According to the method, in a specific tetrahydrofuran solvent, a cinnamyl (fluorosulfonyl) carbamate compound is used as a substrate and reacts under the action of a catalyst and alkali, and the 2-oxo-4-phenyl oxazine sulfonyl fluoride compound is obtained through the reaction. According to the method, iodobenzene diacetic acid and potassium tert-butoxide which are low in price and easy to obtain are adopted as the catalyst and alkali respectively, the substrate applicability is wide, the raw materials are simple and easy to obtain, the economic cost is low, and the target product can be obtained with the good yield.

The invention discloses a method for selectively synthesizing quinazoline-2-ketone sulfonyl fluoride and benzoxazine imine sulfonyl fluoride compounds, and belongs to the field of chemical synthesis of organic fluorine. According to the method, 2-ethynyl-N-[(phenylamino) carbonyl] sulfamoyl fluoride or 2-vinyl-N-[(phenylamino) carbonyl] sulfamoyl fluoride which is low in price and easy to obtain is adopted as the raw materials, the substrate applicability is wide, the raw materials are simple and easy to obtain, and the economic cost is low; in addition, the quinazoline-2-ketone sulfonyl fluoride and benzoxazine imine sulfonyl fluoride compounds can be synthesized in a relatively high yield only in a room temperature environment according to the method disclosed by the invention, and the fluorine-containing building block compounds are widely applied to the fields of medicines, pesticides and click chemistry.

The application discloses a preparation method of a nitrogen-containing heterocyclic compound and an alkali metal salt of the nitrogen-containing heterocyclic compound, and steps of the preparation method of the nitrogen-containing heterocyclic compound comprise: (1) uniformly mixing trithiocyanic acid with a first solvent, introducing sulfuryl fluoride gas or adding an alkenyl sulfonyl fluoride to perform a reaction, and obtaining a crude product through a crude treatment after the reaction is finished; (2) purifying the crude product to obtain the nitrogen-containing heterocyclic compound shown in a structural formula 1; wherein R1, R2 and R3 are each independently selected from -H, -SO2F or -CH2-(CH2) n -SO2F, n is an integer selected from 1-10, and R1, R2 and R3 are not H at the same time. The preparation method of the nitrogen-containing heterocyclic compound and the alkali metal salt of the nitrogen-containing heterocyclic compound can be applied to a large amount of trithiocyanic acid in a lithium battery electrolyte, raw materials are easy to obtain, operation is simple, the yield is high, the condition is mild, the requirement for equipment is low, and the method is suitable for industrial production.

The invention discloses a battery. The electrode according to the present disclosure is a battery having a positive electrode layer, an electrolyte layer containing MeFSA (dimethylaminosulfonyl fluoride) and LiFSI (lithium bis (fluorosulfonyl) imide), and a negative electrode layer containing an Si-based active material as a negative electrode active material, in this order.

This application relates to the field of synthesis technology of lithium-ion battery electrolyte additives, specifically to a synthesis process of 1,3-propanedisulfonyl fluoride. The synthesis process includes the following steps: S1. Adding 1,3-propanedisulfonyl chloride and potassium fluoride to a reaction vessel; S2. Adding distilled water as a reaction solvent to the reaction vessel and refluxing under stirring; S3. After the reaction solution has settled and separated into layers, separating and collecting the oil phase, adding toluene and activated carbon to the oil phase, and refluxing for decolorization; S4. Performing a first crystallization treatment on the decolorized solution, followed by filtration, and washing the filter cake obtained from the filtration; S5. Collecting the filtrate obtained after the first washing and performing a second crystallization treatment, followed by filtration again; S6. Vacuum drying the filter cake obtained in steps S4 and S5 to obtain 1,3-propanedisulfonyl fluoride. This application features mild reaction conditions, simple operation, low cost, and environmental friendliness.

The invention discloses a diaminomaleonitrile derivative, a non-aqueous electrolyte thereof and a sodium ion battery. The structural formula of the diaminomaleonitrile derivative disclosed by the invention is shown as a formula I, and R1, R2, R3 and R4 are respectively and independently selected from one of-SO2F and-CH2CH2SO2F. The diaminomaleonitrile derivative has cyano (-CN), sulfonyl fluoride (-SO2F) and carbon-carbon double-bond functional groups, the functional groups have a synergistic effect, a stable CEI film can be formed on a positive electrode, the contained sulfonyl fluoride group can adjust charge distribution while enhancing the oxidation resistance of molecules, the functions of optimizing an ion transmission path and the like are achieved, and the service life of the battery is prolonged. Therefore, the high-voltage resistance of the battery is improved. Formula 1.

The invention provides a method for rectifying trifluoromethanesulfonyl fluoride, which can be used for effectively purifying trifluoromethanesulfonyl fluoride feed gas containing impurity gases such as HF, CO2, SO2 and the like, and comprises the following steps of: obtaining an azeotrope of trifluoromethanesulfonyl fluoride and HF by using a conventional rectifying process, condensing the azeotrope, settling, splitting phases, and rectifying and purifying again, thereby obtaining the trifluoromethanesulfonyl fluoride. The problem that trifluoromethanesulfonyl fluoride and HF cannot be thoroughly separated through azeotropic distillation is solved. The invention also provides a rectification device of the trifluoromethanesulfonyl fluoride, the rectification device comprises a collecting tower, a light component removal tower, a heavy component removal tower, a settling separation tank and a finished product rectification tower which are connected in sequence, continuous rectification preparation of the high-purity trifluoromethanesulfonyl fluoride is realized, and the purity of the high-purity trifluoromethanesulfonyl fluoride is not less than 99.5%.

The invention provides a perfluorosulfonic acid resin without perfluorooctanoic acid or perfluorooctane sulfonic acid, a preparation method thereof, a catalyst layer and a hydrogen fuel cell membrane electrode. The perfluorinated sulfonic acid resin is formed by copolymerization of monomers containing perfluorinated oxaolefin sulfonyl fluoride and water-soluble perfluorinated oxaolefin sulfonate through an emulsion method, and the perfluorinated oxaolefin sulfonate is obtained by hydrolysis of the perfluorinated oxaolefin sulfonyl fluoride through alkali liquor. The mass ratio of the perfluorinated oxaolefin sulfonyl fluoride to the perfluorinated oxaolefin sulfonate is (4-8): 1. The perfluorinated oxaolefin sulfonate is a double-bond-containing perfluorinated surfactant, can be used as an emulsifier and can also be used as an active polymerizable monomer to participate in a polymerization reaction, and compared with resin which does not contain a double-bond emulsifier in the prior art, the perfluorinated sulfonic acid resin disclosed by the invention has the advantages of higher resin purity and lower cost. The composite material has good proton conductivity, oxygen permeability, mechanical strength, durability and the like.

The invention belongs to the technical field of organic intermediate synthesis, and in particular to a kind of synthetic method and synthesis device of benzenesulfonyl fluoride.The synthetic method of benzenesulfonyl fluoride of the present invention, comprises the following steps: first hydrogen fluoride and sulfuryl chloride are added to a premixer, and successively pass through tubular reactor a, b, c, enter terminal reactor mixed reaction, control gas-liquid two-phase mixed reaction by terminal reactor, vertical condenser a, prepare sulfuryl fluoride chloride, then sulfuryl fluoride chloride, benzene, catalyst are mixed, enter sulfonation reactor reaction, control the progress of sulfonation reaction by sulfonation reactor, vertical filler b, obtain mixed reaction liquid, finally mixed reaction liquid is distilled, collect fraction, obtain benzenesulfonyl fluoride.The synthetic method of benzenesulfonyl fluoride provided by the present invention, reaction condition requirement is low, stable, easy to control, unit consumption is low, subsequent easy processing, prepared benzenesulfonyl fluoride yield is high, purity is high.The present invention also provides the synthesis device adopted by the synthetic method of benzenesulfonyl fluoride.

The invention discloses a multi-component preparation method of an N-sulfonyl fluoride compound, and relates to the field of organic synthesis. The preparation method comprises the following steps: reacting an amine compound with a chlorine source in a solvent to generate an intermediate, then continuously adding a sulfur dioxide source and a fluorine source for reaction, and purifying after one-pot reaction to obtain the N-sulfonyl fluoride compound, the structural general formula of the amine compound is shown in the specification, the structural general formula of the N-sulfonyl fluoride compound is shown in the specification. The reaction general formula is shown in the specification. The method has the advantages of cheap and easily available raw materials, simple operation, mild conditions, safety, environmental protection, short reaction time, good yield and wide substrate range, can be applied to various types of amine substrates, including primary (alkyl / aromatic) amine, secondary (alkyl / aromatic) amine, amide, nitrogen-containing heteroaromatic ring and the like, and has wide application prospects. Wide application prospects are realized in the fields of medicinal chemistry, synthetic chemistry, material science and the like.

The invention provides a synthesis method of a negative charge highly delocalized sulfonyl imide alkali metal salt {[(R3SO2) (R2 (R1SO2N) SO) N] M), M = Li, Na, K, Rb or Cs}. The synthesis method comprises the following steps: carrying out oxidation and fluorination reaction on alkyl (S-alkyl sulfonyl imide) potassium sulfinate (or rubidium or cesium) and an N-fluorine electrophilic reagent to synthesize alkyl (S-alkyl sulfonyl imide) sulfonyl fluoride with the yield of 70-90%; the obtained alkyl (S-alkyl sulfimide) sulfonyl fluoride and sulfamide containing substituent R3 or alkali metal salt thereof are subjected to nucleophilic substitution reaction, the product is purified to obtain the high-purity negative-charge highly-delocalized sulfimide alkali metal salt, and the method has the characteristics that the operation is simple, the raw materials are low in price, the product is easy to separate and purify, the method is suitable for industrial mass production, and the like; and the prepared negative charge highly delocalized sulfimide alkali metal salt is high in chemical stability and good in solubility, and is a preferable electrolyte material for realizing high-specific-energy power and energy storage batteries.

The invention belongs to the technical field of synthesis of bis (fluorosulfonyl) imide, and discloses a method for synthesizing bis (fluorosulfonyl) imide by using sulfuryl fluoride chloride, which comprises the following steps: 1) adding amino sulfuryl fluoride into sulfuryl fluoride chloride for reaction at a reaction temperature; and 2) after the reaction is finished, removing the solvent and unreacted raw materials in the synthetic liquid, and rectifying to obtain the bis (fluorosulfonyl) imide. The byproduct sulfuryl fluoride chloride in the sulfuryl fluoride industry is used as a raw material, the method has the advantages of low cost and high added value, the method is simple to operate, mild in reaction condition and high in conversion rate and yield, and the prepared imidodisulfuryl fluoride is high in purity, good in quality and suitable for large-scale industrial production of imidodisulfuryl fluoride.

The invention belongs to the field of organic synthesis, and relates to a method for synthesizing beta-sulfamide. According to the method, primary amine and alkenyl sulfonyl fluoride are used as raw materials, silica gel is used as a catalyst, and a reaction is carried out in a solvent to generate the beta-sulfamide compound. Compared with a traditional method for synthesizing beta-sulfamide through a multi-step reaction, the beta-sulfamide synthesis method is easy and convenient to operate, mild in condition, low in reagent cost, easy to obtain, high in reaction yield and wide in substrate application range. The invention also discloses an application of beta-sulfamide compounds synthesized from primary amine and alkenyl sulfonyl fluoride under a silica gel catalysis condition in drug modification.

Disclosed are ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent SuFEx connections via lithiated chemistry. In detail, a method of synthesizing an ortho-functionalized benzenesulfonyl fluoride derivative, the method comprises (a) reacting a benzenesulfonyl fluoride derivative represented by structural formula 1 with an organolithium represented by structural formula 2, thus synthesizing an intermediate represented by structural formula 3 in reaction scheme 1 and (b) reacting the intermediate with an electrophile, thus synthesizing a compound represented by structural formula 4 or a compound represented by structural formula 4′. The present disclosure enables the synthesis of several functionalized sulfonyl fluorides within a few seconds under mild temperature conditions in addition to the chemistry of Sulfonyl Fluoride Exchange (SuFEx), which is a next-generation click chemistry, so that sulfonyl fluoride, the main reactant of the SuFEx reaction, can be efficiently secured.

The invention discloses a preparation method of an N-hydroxyurea compound, which specifically comprises the following steps: step 1, sequentially carrying out Lossen rearrangement and nucleophilic reaction under the action of alkali by taking Boc NHOH as shown in a formula 1 as an initial reactant, SO2F2 gas as an acylating agent and an amine compound RR 'NH as a nucleophilic reagent to obtain a tert-butoxyurea compound as shown in a formula 2; and 2, removing the tert-butoxy group from the tert-butoxyurea compound to obtain the N-hydroxyurea compound as shown in a formula 3. The innovation point of the invention is that commercialized easily available gas sulfonyl fluoride promotes Lossen rearrangement of tert-butylhydroxylamine to generate a key intermediate tert-butoxy isocyanate, the key intermediate tert-butoxy isocyanate and a substrate amine compound are subjected to a one-pot reaction to obtain the N-hydroxyurea compound, the reaction conditions are simple, the operation is convenient, the compatibility of substrate functional groups is strong, and the application prospect is good.