1050 results about "Click chemistry" patented technology

A biodegradable antithrombotic conjugate having heparin and other anti-thrombotic moieties are introduced as side chains to the polymer backbone modified by click chemistry. Various bioabsorbable monomers and dimers such as valerolactone may be used in the monomer derivation, homo- and co-polymerization, and the conjugation with a biologically active molecule by click chemistry. A coating comprising a biocompatible and bioabsorbable polymer anti-thrombotic conjugate is applied to at least a portion of an implantable device to prevent or reduce the formation of thrombosis on the surface of the implantable device. A first or sub-layer of the coating is prepared by mixing a polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer comprising the present anti-thrombotic conjugate may be applied over the inner drug-containing layers using, for example, a dip coating or spray coating process.

The present disclosure provides compositions which may be utilized as adhesives or sealants in medical and surgical applications. The compositions may, in embodiments, be formed from the cycloaddition reaction of a first component possessing at least one azide group with a second component possessing at least one alkyne group.

The invention discloses a cyclodextrin chiral stationary phase, the structure of which is shown in the general formula (I), wherein X is -OCH3 or -OCH2CH3, n is equal to 1-7, and R is -H, -CH3, -COCH3, -COC6H5 and -CONHC6H5. The preparation method of the stationary phase comprises the following steps: a silane coupling agent, sodium azide and a catalyst are added into an organic solvent, then spheroidal silicon is added for preparing azide silica gel derivant; oligomeric ethylene glycol, sodium hydride and propargyl bromide are added into tetrahydrofuran for preparing bialkynyl oligomeric ethylene glycol; monosubstituted nascent and derivative cyclodextrin containing azid groups is prepared; finally, the click chemistry reaction method is used for bonding the cyclodextrin. The cyclodextrin chiral stationary phase has the advantages that the selectivity of the bonding reaction is high, and the surface bonded amount is large; the chiral separation ability is strong, thereby being especially suitable for the chiral separation of a high efficiency liquid chromatography in the reversed-phase mode; the preparation method is simple and has less steps, the bonding reaction is the click chemistry reaction, the reaction condition is mild, and the reaction is carried out in the water solution.

The invention relates to novel hybrid compounds comprising at least one silicone entity (Sil) in which at least one of the silicons of Sil is substituted by at least one unit—Ro-B, B being an entity of a variable nature, for example polymer, hydrocarbonated or mineral, selected from a group comprising polyols (e.g. saccharides), silicones, polyalkylene glycols, polyamides, polyesters, polystyrenes, alkyls, alkenyls, alkynyls or aryls, in addition to mineral materials such as silica and the combinations thereof. The bond Ro between the entity Sil and the entity B is obtained by means of “click chemistry” and corresponds to formula (II.1) or (II.2), Z representing a carbon atom or a nitrogen atom. Said hybrid components can be used as emulsifiers, especially for cosmetics.

The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.

The invention provides a method for identifying a candidate imaging probe, the method comprising: a) contacting a first library of candidate compounds with a target biomacromolecule, b) identifying a first member from the first library exhibiting affinity for the first binding site; c) contacting the first member identified from the first library affinity for the first binding site with the target biomacromolecule; d) contacting a second library of candidate compounds with the first member and the target biomacromolecule, e) reacting the complementary first functional group with the second functional group via a biomacromolecule induced click chemistry reaction to form the candidate imaging probe; f) isolating and identifying the candidate imaging probe; g) preparing the candidate imaging probe by chemical synthesis; and h) for imaging applications, converting the candidate imaging probe into an imaging probe.

The invention discloses an amphion polymer modified anti-adhesion surface with dopamine as an anchor, and a making method thereof. The making method comprises the following steps: modifying the surface of a base material with dopamine methacrylamide under alkaline conditions, wherein the base material is not pretreated before modification; and grafting the surface of the base material with a thio group-containing amphion polymer through a thio-ene click chemical reaction under ultraviolet light initiation conditions to prepare the amphion polymer modified anti-adhesion surface with dopamine as anchor. The base material which can be modified comprises glass flakes, mica sheets, wood blocks, polyethylene glycol terephthalate, nonwoven fabrics, cotton fabrics and metal sheets; and the amphion polymer modified anti-adhesion surface with dopamine as an anchor has a good anti-adhesion effect on bacteria, and the antibacterial adhesion effect of the surface immersed in water for 5d has no obvious decreasing trend.

The invention discloses a click chemistry based metal-organic framework cross-linking membrane and a preparation method and application thereof.Polymerizable double bonds are introduced into MOFs (metal-organic frameworks) through a post-synthetic modification method, and the chemical cross-linking type MOF membrane is prepared in situ by thiol-ene click reaction, so that a novel rapid efficient solvent-free method mild in conditions is provided for MOFs membrane synthesis.By means of applying the strategy, an obtained independent homogeneous MOFs hybrid membrane material is excellent in membrane forming performance and toughness, and the defects of agglomeration of MOFs crystals and poor compatibility between the MOFs and polymers are overcome.The synthesized MOFs membrane material is excellent in selective separation effect on dye molecules in water and has a promising application prospect in the field of membrane separation.

The invention discloses an ultraviolet curing reaction-based fluoride-free and water-repellent finishing method of cotton fabric. The method comprises the steps of putting the cotton fabric into 3-mercaptopropyl triethoxysilane ethyl acetate solution and carrying out mercapto modification to obtain pretreated cotton fabric; dipping the cotton fabric subjected to mercapto modification into vinyl polyhedral oligomeric silsesquioxane solution, and obtaining the fluoride-free and water-repellent cotton fabric, which has a surface with an approximate super-hydrophobic effect, under the ultraviolet curing condition. The reaction is based on the principle of click chemistry, so that a static contact angle is basically remained unchanged after soaping treatment is carried out. Furthermore, according to a test method of AATCC 22-2005 waterproof spray test, the waterproof spray test score of the cotton fabric subjected to water-repellent finishing reaches 95. The ultraviolet curing reaction-based fluoride-free and water-repellent finishing method of the cotton fabric is simple in operation and high in efficiency, obvious in water-repellent effect under the condition that a finishing agent is fluoride-free, and high in finishing washing fastness.

The invention belongs to the technical field of chemical material preparation, and particularly relates to a method for modifying an elastomer by using click reaction of thiol-ene. The method is characterized in that isolate double bonds in an elastomer material are crosslinked with an elastomer compound system by using click chemistry of thiol-ene with the participation of polythiol organic molecules under an UV-irradiation condition so as to achieve the purpose of modifying the elastomer material. The method for modifying the elastomer is simple, easy in obtaining of raw materials and relatively low in cost. The obtained composite material has excellent mechanical property and can be widely applied.

The invention relates to a method for preparing high-dispersity nanosilicon dioxide particles. The method comprises the following steps: firstly, modifying nanosilicon dioxide particles to graft an azide group on the surfaces of the nanosilicon dioxide particles, preparing a polymer with a plurality of alkynyl groups on a non-terminal group of the molecular chain in a free radial polymerization mode, and finally the surfaces of the particles with the polymer through click chemistry reaction. The modified nanosilicon dioxide particles prepared by using the method are good in dispersity in organic solvents, overcome the problem of easy conglobation and have great application potential in the fields of coatings, composite materials and the like.

The invention discloses a method for preparing a hyperbranched polymer through dual click chemistry. The method comprises the following steps of: 1) adding one mole of bis(thiol) compound, 0.1 to 10 moles of solvent, 0.05 to 2 moles of base catalyst, and 0.9 to 1.1 moles of compound containing alkynyl and alkenyl into a reactor sequentially under the protection of nitrogen, performing sulfydryl-alkene addition reaction at the temperature of between 10 and 40 DEG C for 0.5 to 24 hours, and performing reduced pressure evaporation to remove the solvent; and 2) dissolving the product obtained in the step 1) in 0.25 to 10 moles of solvent under the protection of nitrogen, adding 0.005 to 0.05 mole of photosensitive radical initiator or thermosensitive radical initiator, irradiating by ultraviolet light or heating at the temperature of between 40 and 90 DEG C to produce radical, performing sulfydryl-alkene addition polymerization reaction for 0.5 to 24 hours, and precipitating, separating and drying to obtain the hyperbranched polymer. The method has the advantages of no need of complex AB2 monomer synthesis and purification steps, high speed and efficiency, convenience, wide application range and the like. The obtained hyperbranched polymer containing a large amount of thioether bonds has wide application prospect in the fields of biomedical carriers, high-performance materials, additives and the like.

The invention provides a portable copper ion concentration detection method based on click chemistry and belongs to the field of analytical chemistry. Under the condition that sodium ascorbate reduces cupric into cuprous as a catalyst, a 1,3-dipole cycloaddition reaction is carried out between NDA modified with an azide group and DNA modified with an alkynyl group, so that DNA modified with cane sugar invertase is fixed on magnetic beads; The magnetic beads are separated from a solution, the cleaned magnetic beads are dissolved into a cane sugar solution to carry out enzymatic hydrolysis, and then a reaction solution after enzymatic hydrolysis is measured by adopting a blood glucose meter, so that copper ion concentration can be detected. The portable copper ion concentration detection method provided by the invention takes the blood glucose meter as a platform and can portably and quickly detect the copper ion concentration on site; and the portable copper ion concentration detection method can be applied to copper ion detection in a human body serum sample, and the portable copper ion concentration detection method has the advantages of easy operation, low cost, high sensitivity and good specificity.

The invention relates to fluorosilicone resin based on click chemistry and a preparation method of a self-repairing superhydrophobic coating. Through click chemistry, low surface energy and a self-repairing function are led into a multi-level rough structure of nanoparticles fixed by a polyurethane adhesive, and the superhydrophobic/amphiphobic interfacial material with high mechanical strength and the self-repairing function is prepared. As a self-designed low-surface-energy segmental grid structure of polyfunctional fluoroalkyl silane is adopted, by use of the principle that a damaged surface is covered with self-repairing segmental orientation, the defects that low-surface-energy molecules in a conventional self-repairing material are long in migration time and high in probability of loss are overcome, and a new method is provided for realizing quick and long-acting self-repairing of the superhydrophobic coating.

The invention belongs to the technical field of synthesis and preparation of polymer materials, and discloses a synthetic method of triblock polymer, wherein stepwise polymerization (SGB), atom transfer radical polymerization (ATRP) and click chemistry method are combined at first; and 1, 3-dipolar cycloaddition reaction is performed to polymer with azido terminal group and polyurethane prepolymer with alkynyl terminal group to successfully synthesize triblock polymer containing triazole ring. The synthesis method provided by the invention overcomes the defects in traditional block polymer synthesis that reaction conditions are strict, molecular weight distribution is controlled difficultly, and selectable classes of monomers are less, and has the advantages of high conversion rate, mild reaction conditions, narrow molecular weight distribution and strong controllability. The triblock polymer provided by the invention has potential application in ways of medicine slow release, solubilizers and surfactants.