68results about How to "Preparation reaction conditions are mild" patented technology

The invention discloses a method for preparing pyrazole derivatives and a clinic breast cancer treatment drug tetra-substituted olefin (Z)-Tamoxifen from sulfopolysubstituted olefin. The method comprises the following steps: carrying out a condensation cyclization reaction of a raw material alpha-carbonyloxo ketene monothioacetal and a nucleophilic reagent hydrazine to prepare the pyrazole derivatives; and carrying out a coupling reaction of the alpha-carbonyloxo ketene monothioacetal raw material and arylboric acid to prepare the tetra-substituted olefin Tamoxifen. Compared with pyrazole derivatives and (Z)-Tamoxifen prepared through reported preparation methods, the above products in the invention have the advantages of good regioselectivity and stereoselectivity, easily available raw materials, simple operation, mild preparation reaction conditions and high efficiency.

The invention discloses a method for preparing a glycolic acid compound from 1, 3-dihydroxyacetone. According to the method, 1, 3-dihydroxyacetone as a reaction raw material undergoes a reaction at 0-100 DEG C in a reaction medium in the presence of a composite catalyst and an oxidant for 2-48h to produce the glycolic acid compound. The method is simple and is used under mild reaction conditions.The method can acquire a desired product in low cost and high yield so that the catalyst has high catalytic activity, can be separated from the reaction system and reused, and is environmentally friendly. Compared with the existing petroleum-based small molecule feedstock conversion method, the method provided by the invention promotes use of a biodiesel by-product 1, 3-dihydroxyacetone and is a potential, eco-friendly, efficient and economical glycolic acid production method.

The invention discloses aminosilicone durable hydrophilic potentiating agent, and a preparation method and the application thereof. The preparation method is that methyl silicone oil containing hydrogen, allyl-terminated epoxy-terminated compound and allyl polyether are reacted under the effect of platinum catalyst in oxygen-free condition, so that the aminosilicone durable hydrophilic potentiating agent is obtained. The method has the advantages that the reaction step is simple, the reaction condition is mild, and the method is simple and easy. The aminosilicone durable hydrophilic potentiating agent not only can be independently used before and after the softening finish of traditional aminosilicone, but also can be co-bathed with traditional aminosilicone emulsion; as the agent has good penetrability, wettability and reactivity, the agent can not only keep the soft and smooth feel of the traditional aminosilicone, but also give good hydrophilicity to fabrics in the condition that the use level is low, and also has durability; and the difference between the fabric finished by the aminosilicone durable hydrophilic potentiating agent and the fabric finished by the independently used traditional traditional aminosilicone emulsion is that fabric treated by the aminosilicone durable hydrophilic potentiating agent can be directly repaired without treatment.

The invention provides a comb-like polymer fluid loss additive for drilling fluid and a preparation method thereof. The preparation method comprises the following steps of: performing esterification on polyethylene glycol monomethyl ether (PEGM) and maleic acid (MA) to obtain macromonomers; and adding two monomers, namely acrylamide (AM) and 2-acrylamido-2-methylpropanesulfonic acid (AMPS) into the macromonomers to perform copolymerization so as to obtain the comb-like polymer fluid loss additive with a long side chain by a solution polymerization method. The prepared comb-like polymer fluid loss additive has the advantages of resisting the temperature of 200 DEG C in the drilling fluid, along with good fluid loss reducing effect on the drilling fluid such as fresh water, saline and the like, capacity of controlling the drilling liquid to keep high rheological property under the condition of high temperature and high salinity, high temperature and salt resistance, stable fluid rheological property, mild synthesis condition, low equipment requirement and simple process.

The invention discloses a silicon-based carborane polymer and a preparation method thereof. Specifically, 1,1'-hydrocarbylsilyl-2,2'-bis(dimethylsilyl)biscarborane is used as the reaction raw material to prepare 1,1'-hydrocarbylsilyl-2,2'- Bis(hydroxydimethylsilyl)biscarborane; starting from trivinyltrimethylcyclotrisilazane, reacted with dimethylchlorosilane to obtain 1,3,5‑trimethyl ‑1,3,5‑three[ β ‑(Dimethylchlorosilyl)ethyl]cyclotrisilazane, through polycondensation, the obtained copolymer is reactive, and the polymer can be coated on the surface of carbon fiber to obtain the protection of silicon-based carborane crosslinked polymer Carbon fiber material, the prepared carborane has very excellent heat resistance and oxidation resistance. The silicon-based carborane polymer provided by the invention has simple and convenient preparation process, mild preparation reaction conditions, easy-to-obtain raw materials, and is suitable for industrial scale-up production.