443 results about "Propanamide" patented technology

The invention relates to a salt-tolerant resistance-reducing agent applied for a shale gas reservoir. The resistance-reducing agent is a biopolymer comprising an acrylamide unit and a propenyl quaternary ammonium salt unit. The weight percent of the acrylamide in the biopolymer is 10%-80%. The propenyl quaternary ammonium salt is one of a propenyl trialkyl ammonium chloride, an alkyl acrylamido propyl trialkyl ammonium chloride or a dialkyl diallyl ammonium chloride. The weight percent of the propenyl quaternary ammonium salt in the biopolymer is 20%-90%, and the molecular weight of the propenyl quaternary ammonium salt is 1*10<6> to 2*10<6>. The resistance-reducing agent provided by the invention can be used as resistance-reducing agents for fracturing flow-back fluid, cavern water and underground produced water, wherein the fracturing flow-back fluid, the cavern water and the underground produced water contain divalent metal ions, and the weight percent resistance-reducing agent provided by the invention for using is 0.05%-0.1%. The resistance-reducing agent provided by the invention has good salt tolerance and resistance-reducing properties, and overcomes problems, of other polypropanamide resistance-reducing agents at present, comprising salt tolerance deficiency in using processes and incapability of being applied for hypersalinity water that comprises Ca<2+> and Mg<2+> at the same time.

The invention relates to the use of selected (R)-2-[(halobenzyloxy)benzylamino]-propanamides and the pharmaceutically acceptable salts thereof for the manufacture of medicament, that are selectively active assodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, pain, migraine, periferal diseases, cardiovascular diseases, inflammatory processes affecting all body systems, disorders affecting skin and related tissues, disorders of the respiratory system, disorders of the immune and endocrinological systems, gastrointestinal, urogenital, metabolic and seizure disorders, where the above mechanisms have been described as playing a pathological role.

The invention discloses a preparation method of new polymer monomer N, N-dialkyl acrylamide and the improvement of a process route, that is, under the existance of polymerization inhibitor and the function of catalyst, the 3-dialkyl amidocyanogen propanamide shown in the formula (I) goes through thermal cracking reaction for two the twenty hours under the conditions of temperature between 100 DEG C and 280 DEG C and pressure between 200 mmHg and 760 mmHg, and after a cracking product is processed, the N, N-dialkyl acrylamide shown in the formula (II) is obtained. Because acid as catalyst is added into the reaction system, the activation energy of the thermal cracking reaction is lowered, the reactive selectivity and the reactive yield rate are increased, and therefore energy consumption is reduced. Compared with the original cracking technique, the temperature of cracking is lowered, the time of reaction is shortened, that is, the time of reaction is shortened to a few hours from over twenty hours, the yield rate of cracking is increased, and byproducts are reduced.

The invention discloses a novel ester group-containing aromatic propionamide compound as well as a preparation method and an application thereof, and provides a chemical structure formula of the novel ester group-containing aromatic propionamide compound. The compound is prepared by taking an acyl chloride compound and proline as starting raw materials. The compound has the effect of adjusting an androgen receptor and can be independently used or being used as a composition to be used for treating and/or preventing various diseases related to androgens, such as diseases of male androgen deficiency (ADAM), diseases of female androgen deficiency (ADIF), muscle consumption, muscle emaciation, amyotrophy, osteoporosis, sclerotin reduction, anemia, obesity, diabetes mellitus, cancers and the like; the compound can also be used for an exercise and/or body function enhancing agent or an animal feed additive.

The invention discloses an extraction composition, an extraction system and application thereof. The extraction composition disclosed by the invention comprises an extraction agent and a neutral phosphorus oxide compound of formula A as shown in the description, wherein the extraction agent comprises N,N-di(2-ethylhexyl) acetamide and N,N-dihexyl-2-mehtyl propanamide. As a mixture of amide compounds and the neutral phosphorus oxide compound of specific structures is adopted as the extraction agent, the extraction rate for Li of lithium-containing brine is 80% or greater, for example, 83.41-93.5%; the lithium-magnesium allocation coefficient is as high as 600 or greater, for example, 625-1110; when lithium is reextracted with HCl, the reextraction rate is 85% or greater, for example, 87.55-91.32%, the extraction and reextraction properties for extracting lithium from the lithium-containing brine are greatly improved, the cost is reduced, and industrial production can be relatively well met.

This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydroxylated and/or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

The present invention provides compounds of Formula (I):

or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L₁, M and R¹¹ are as defined herein. The compounds of Formula (I) are selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Compounds of formula (I)

wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are useful in hormonal therapy, e.g., in the treatment or prevention of male hypogonadism and age-related conditions such as andropause.

The invention relates to a 3-methylene-indole-2-ketone derivative and a preparation method thereof. The derivative is synthesized by taking N-methyl-N-phenyl-hydrocinnamamide or N-aryl phenylpropargyl acylamide and phthalic imide as substrates through tandem reactions such as C-H activation/ acetylene hydrocarbon palladinization/cross coupling and so on, based on the catalysis of Pd<II>/Pd<IV> under the coaction of a palladium catalyst and an oxidizing agent, then ethyl acetate is added, the mixture is scrubbed by common salt, an aqueous phase is then extracted by the ethyl acetate, an organic layer is collected, and the 3-methylene-indole-2-ketone derivative is prepared through drying, condensation and column chromatography. The preparation method has the advantages of simple and convenient reaction operation, short reaction steps, simple conditions, short time, low cost, and high yield, and is worthy to be popularized and applied.

The invention discloses a recombinant carbonyl reductase derived from Burkholderia gladioli ZJB-12126 and a coding gene thereof, a recombinant vector containing the gene, a recombinant gene engineering bacterium converted from the recombinant vector and application in preparing the recombinant carbonyl reductase.2-benzoylaminomethyl-3-one butyrate, N,N-bis-methyl-3-one-3-(2-thienyl)propanamide, ethyl 4-chloroacetoacetate (COBE) and tert-butyl (R)-6-cyano-5-hydroxy-3-carbonylhexanoate used as substrates are subjected to biological catalytic reaction to prepare high-optical-purity (2S,3R)-2-benzamidomethyl-3-hydroxybutyrate, (S)-N,N-bis-methyl-3-hydroxy-3-(2-thienyl)propanamide, ethyl (S)-4-chloro-3-hydroxybutyrate and tert-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate.

This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydroxylated and/or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

The invention relates to a preparation method for a natural cellulose melt-blown non-woven fabric with a burning-resistant function. The preparation method comprises the following steps of: mixing wood pulp with a methyl morpholine oxide solvent to form a pulp solution; removing water by a vacuum film evaporator to form a spinning adhesive solution; extruding the adhesive solution from a spinning hole in a melt-blowing way to form a cellulose tow; solidifying, regenerating, washing by water, rolling by a water needle and drying to prepare a natural cellulose non-woven fabric; carrying out pad-rolling on the natural cellulose non-woven fabric and a burning-resistant agent namely N-hydroxymethyl-3-(dimethoxy phosphoryl) propanamide; drying, baking, neutralizing, soaping, washing by the water and drying in sequence; finally washing by alkali, washing by water, drying and rolling to prepare the natural cellulose non-woven fabric with the long-acting burning-resistant function. According to the preparation method, the natural cellulose non-woven fabric and the burning-resistant agent namely N-hydroxymethyl-3-(dimethoxy phosphoryl) propanamide can produce a special crosslinking reaction in the preparation process, the burning-resistant effect of the natural cellulose melt-blown non-woven fabric completely conforms with the test standards of ASTM (American Society for Testing Material) D6413-1999 and ASTM D2863-1995, and the natural cellulose melt-blown non-woven fabric can be naturally decomposed after being used and thrown away, so that the natural cellulose melt-blown non-woven fabric becomes an environment-friendly material harmless to the natural environment.

The invention discloses an anti-fog coating material and a preparation method thereof. The anti-fog coating material comprises the following components, in parts by mass: 20-40 parts of acrylic resin, 15-25 parts of alkyd resin, 10-20 parts of epoxy resin, 5-15 parts of sodium aliphatate, 10 parts of a binary block copolymer containing propanamide and hydroxyethyl ester, 5-25 parts of a surfactant, 8-12 parts of inorganic nanometer particles, 0.3-0.6 part of an antifoaming agent, 0.1-3 parts of a coupling agent and 1-3 parts of essence. According to the anti-fog coating material disclosed in the invention, the hydrophilicity is high, fog resistance and bright-light resistance are good, and the stability is high, and the coating material mainly used in the fields which need long-efficiency and high-quality fog resistance such as architectural glass, automobile window decorations, ocean ships, and port glass facilities, and practicability and security of devices can be effectively increased.

The invention discloses a carbonyl reductase (i)Ch (/i) KRED15 derived from Chryseobacterium ((i) Chryseobacterium (/i) (i) (/i) sp. CA49), and a coding gene thereof; the invention also discloses application of the carbonyl reductase as a biocatalyst in preparing a Duloxetine chiral intermediate ((i) S (/i))-N-methyl-3-hydroxy-3-(2-thienyl) propanamide. The enantiomer excess of products is greater than 99.9%. 20 g/L of substrate can be catalyzed by Ch(/i) KRED15 crude enzyme (2U/mL), and the conversion rate of over 99% can be obtained in 2 hours; a coenzyme circulation system is simple, and has large industrial application prospect.

Disclosed is an alkoxy ethoxy propyl isothiazolinone, whose molecule formula is C8H10Cl2NO3SR, the preparation comprises reacting Na2Sx with acrylic methyl ester to obtain dithiodipropionic dimethyl ester, then reacting with alkoxy ethoxy alanine to obtain N, N'-dialkoxy ethoxy propyl dithioamides, and the latter further reacting with sulfuryl chloride. The invention can realize an antifouling agent for rapid degradation in the environment, very small influence to the biological availability for sea creatures can be achieved.

The invention provides a cinacalcet hydrochloride preparation method which comprises the following steps: (A) by taking trifluoromethylcinnamic acid as a raw material and palladium on carbon as a catalyst, performing hydrogenation reduction to obtain m-trifluoromethylbenzoic acid; (B) performing condensation reaction on the m-trifluoromethylbenzoic acid and R-(1) naphthylethylamine, thus obtaining (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(trifluoromethyl)phenyl)propanamide; (C) performing catalytic reduction on the (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(trifluoromethyl)phenyl)propanamide to obtain cinacalcet; and (D) reacting the cinacalcet and hydrochloric acid to obtain cinacalcet hydrochloride. The method has the advantages of thorough reaction, high yield, no pollution in the reaction process and the like.

The invention provides a preparation method of an ionic liquid for absorbing SO2, and an application of the ionic liquid in absorbing SO2. The preparation method of the ionic liquid comprises the steps of uniformly mixing one of aluminium chloride, zinc chloride, lithium chloride, aluminum sulfate, zinc sulfate, lithium sulfate, aluminium nitrate, zinc nitrate and lithium nitrate with one or two of urea, propanamide, butyramide, caprolactam, N,N-dimethylformamide and N,N-dimethylacetamide at a molar ratio of 1:(1-10) or 1:(0.5-3):(1-7), conducting reaction for 1-10h at 70-150 DEG C, conducting vacuum drying on an obtained solution at 40-60 DEG C, and obtaining the ionic liquid. The ionic liquid is mainly used for quickly and efficiently absorbing SO2. With the adoption of the ionic liquid as an SO2 absorbent, requirements on equipment required for absorbing SO2 are simple, the operational conditions are mild, the absorption efficiency is high, the cost is low, the ionic liquid can be recycled, and waste liquid and waste water discharge and other problems do not exist, and the ionic liquid is suitable for industrial production, meets the requirements of green chemical development of the contemporary society, and has good economic and social benefits.

The invention discloses a viscosity stabilizer for an oil-displacing polymer solution and a preparation method of the viscosity stabilizer. The stabilizer composition includes a solvent and additives;the additives are at least two selected from the group consisting of an antioxidant, an anti-salt agent and a bactericide; the antioxidant is at least one selected from the group consisting of thioethanol, thiourea, thiodipropionic acid, sodium thiosulfate, potassium iodide, 2-hydroxyethylamine and acetone; the anti-salt agent is at least one selected from the group consisting of ethylenediaminetetraacetic acid or a salt thereof, 1-hydroxyethylidene-1,1-diphosphonic acid or a salt thereof, polyacrylic acid and sodium citrate; and the bactericide is at least one selected from the group consisting of N,N-dimethyldithiocarbamic acid sodium salt, methylene dithiocyanate, 2,2-dibromo-3-cyanoacetamide, 2-nitro-2-bromo-1,3-propanediol, glutaraldehyde and isothiazolinone. The stabilizer solves the problem of large viscosity loss of the polymer solution during polymer displacement.

The invention discloses a synthetic method of a parecoxib sodium impurity, namely N-[[3-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide, belonging to the technical field of chemical pharmacy; the parecoxib sodium impurity is obtained by carrying out sulfonation reaction, amination reaction and propionylation reaction by taking 5-methyl-3,4-diphenyl isoxazole as the raw material; the synthesized high-purity parecoxib sodium impurity can be used as an impurity standard sample in detection and analysis of parecoxib sodium finished products; therefore, the accurate positioning property and the qualitative diagnosis to impurities in detection and analysis of parecoxib sodium finished products are increased; control of the impurity is strengthened easily, so that the quality of the parecoxib sodium finished products is increased; the synthetic method disclosed by the invention is cheap and available in raw materials and simple to operate; the yield of the prepared parecoxib sodium impurity is 85+/-5%; and the HPLC (High Performance Liquid Chromatography) purity is more than or equal to 98%.

The embodiment of the invention discloses a method for preparing N-hydroxymethyl-3-(dimethoxyphosphoryl) propionamide, which comprises the following steps of: leading acrylamide, dimethyl phosphite and a catalyst to react in a solvent to obtain dimethyl (3-amino-3-acyl propyl) phosphonate, wherein the catalyst is a nonacid compound of alkaline earth metal; leading dimethyl (3-amino-3-acyl propyl) phosphonate to react with formaldehyde to obtain the N-hydroxymethyl-3-(dimethoxyphosphoryl) propionamide. In the invention, the nonacid compound of alkaline earth metal is used as the catalyst. Because the nonacid compound of alkaline earth metal is solid matter, the reactants including acrylamide and dimethyl phosphite can be in good contact with the solid catalyst. Meanwhile, the surface of the solid catalyst has high catalyst concentration to ensure that the catalyst is easy to initiate the reaction. Thus, the preparation method provided by the invention ensures short reaction time and high reaction efficiency.