The invention discloses a graphene resistance-reducing agent for a fracturing fluid. The graphene resistance-reducing agent comprises the following raw materials by weight: 1 to 50 parts of graphene, 5 to 60 parts of a surfactant and 1 to 60 parts of a wetting agent, wherein the surfactant is a nonionic surfactant or anionic surfactant and is one or more selected from a group consisting of alkylphenol polyoxyethylene ether, stearyl alcohol polyoxyethylene polyoxypropylene ether, polyether phosphate, dodecylbenzene sulfonic acid and fatty alcohol ether sodium sulfate-AES. The graphene resistance-reducing agent has the advantages of good resistance-reducing performance, few components, small filtration loss, high viscosity, environment friendliness and good compatibility; through addition of graphene or modified graphene, a lubrication coefficient can be effectively decreased, frictional resistance between the fracturing fluid and a crack wall is lowered and filtration loss is reduced; thus, construction pressure in the process of fracture is reduced, and the graphene resistance-reducing agent is applicable to large-scale large-discharge volume fracture technology. The graphene or modified graphene resistance-reducing agent has good compatibility with a reservoir in the process of fracture and acidification, does not contain mineral oil and poses no pollution to the reservoir and environment.