The utility model relates to a thermistance material with high uniformity and negative temperature coefficient. The main formulation is one in the six systems of Mn-Ni-Cu, Mn-Co-Cu, Mn-Co-Ni-Cu, Mn-Co-Fe-Cu, Mn-Co-Ni or Mn-Co-Fe. The combination of at least two of the oxides as CaO, ZnO, SiO2, Al2O3, Fe2O3, MgO, Cr2O3, TiO2, Sb2O3, Bi2O3, SrO, Nb2O5 and B2O3 are added to the main formulation. The utility model also relates to a preparation method for preparing the thermistance material with high uniformity and negative temperature coefficient, comprising the following steps: mixture making, primary wet milling, drying, calcining, and secondary wet milling, drying and granulating, pressing and forming, and sintering. The utility model has the advantages that: the thermistance material with negative temperature coefficient (NTCR) made by the method has high uniformity and high repeatability; the specific resistance uniformity of the same batch material is all better than plus or minus 1%; the specific resistance error of different batches does not exceed plus or minus 2%; the error of value B does not exceed plus or minus 1%; the utility model is suitable for mass and large-scale production.