4results about How to "Improve colloidal stability" patented technology

This invention belongs to the fields of biomedical materials and colloid chemistry, and discloses a structurally remodeled egg yolk low-density lipoprotein biomimetic liposome and its application in regulating cholesterol metabolism. The method includes extracting and purifying natural egg yolk low-density lipoprotein; selectively removing endogenous cholesterol by adding β-cyclodextrin under alkaline conditions; adding a phytosterol ethanol solution to the cholesterol-removed low-density lipoprotein dispersion, followed by incubation and dialysis purification to obtain the biomimetic liposome. The obtained biomimetic liposome uses partially cholesterol-removed egg yolk low-density lipoprotein as its structural framework, with phytosterols embedded in its phospholipid monolayer and lipid core interface. This biomimetic liposome can inhibit cholesterol micelle formation, reduce cholesterol absorption, promote macrophage cholesterol efflux, and inhibit macrophage foam formation. It can be used to prepare cholesterol metabolism regulating materials, functional delivery systems, and dietary supplement products.

The present invention relates to nanostructures that, after in vivo administration, are excreted in the urine via the kidneys without being phagocytosed by macrophages and / or metabolized, and their use as pharmaceutical compositions. A nanostructure for in vivo administration according to the present invention comprises (i) a spherical core formed by crosslinking two or three dextran molecules with an average molecular weight of 10,000 Da or less using a crosslinker and (ii) a discontinuous shell with divalent or trivalent iron ions coordinationally bonded to crosslinker-derived hydrophilic groups on the surface of the spherical core; and (iii) a mass ratio of dextran to iron ranging from 100 : 2 to 100 : 10, with a crosslinker substitution ratio adjusted to 10% to 50% of the total number of functional groups on the dextran, while 20% to 50% of the crosslinker does not participate in crosslinking at the terminal end, resulting in the nanostructure having the charge ranging from -20 mV to 0 mV; (iv) wherein only 20% to 80% of the crosslinker-derived hydrophilic groups externally exposed on the surface of the spherical core bind iron ions, while the remainder do not bind iron ions and are exposed to an aqueous environment.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a hyaluronic acid-modified co-supported nanoparticle, its preparation method, and its application. The nanoparticle has a core-shell structure, with the core being a coordination complex of zinc-doped Prussian blue and sinomenine hydrochloride, and the outer shell being a bovine serum albumin-hyaluronic acid conjugate. This invention improves the therapeutic effect on knee osteoarthritis.

The application discloses a ratio type fluorescent nanometer thermometer and a preparation method and application, and is prepared as follows: a polybasic saturated fatty acid is heated and melted into a liquid state, and after cooling, a solid is formed; the solid is ground into powder; the powder is heated and melted into a liquid to obtain A liquid; ACQ fluorescent molecules and an AIE molecule with an aggregation-induced emission property are dispersed in the A liquid, and after cooling, a solid is obtained; the solid is ground into powder to obtain powder B; the powder B is dissolved in dimethyl sulfoxide to prepare a B solution; the B solution is added dropwise into an aqueous solution of a non-intercalated surfactant; after the dropwise addition is completed, stirring is continued for 20-40 min; and excess non-intercalated surfactant is removed by dialysis; the thermometer has a temperature detection range of 25-48 DEG C, effectively covering the physiological temperature of 37 DEG C; the thermometer has excellent sensitivity and accuracy, and the maximum relative thermal sensitivity thereof in a water environment is as high as 63.66% / DEG C, which is much higher than that of a previously reported ratio type fluorescent nanometer thermometer.