9results about How to "Improve colloidal stability" patented technology

The invention relates to the technical field of biological medicines, and discloses hyaluronic acid modified metal coordination albumin nanoparticles as well as a preparation method and application thereof. The hyaluronic acid modified metal coordination albumin nanoparticle comprises a core and a hyaluronic acid shell layer, wherein the core is formed by self-assembly of an albumin-drug compound, poly-L-aspartic acid and ferric ions through coordination, and the hyaluronic acid shell layer is connected to the surface of the core through coordination or adsorption. According to the hyaluronic acid modified metal coordination albumin nanoparticles as well as the preparation method and the application thereof, the preparation method is simple, convenient and rapid, does not need complex covalent modification, is mild in condition and is easy for large-scale production, and the prepared nanoparticles are uniform in particle size, good in stability and high in stability. In addition, due to the fact that the hyaluronic acid is modified on the surface, the active targeting capacity on CD44 receptor high-expression tumor cells is achieved, the enrichment and treatment effects of the medicine on the tumor site are remarkably improved, and the application prospect in preparation of the anti-tumor medicine is wide.

The invention belongs to the technical field of functional food, and particularly relates to plant silicon water capable of improving atherosclerosis and a preparation method of the plant silicon water. The method comprises the following steps: S1, mixing silicon tetrachloride, high-purity oxygen and hydrogen to obtain mixed gas; s2, introducing the mixed gas into a radio frequency induction plasma torch to generate silicon-containing gas; s3, the silicon-containing gas is subjected to temperature programming, purging and deacidification under nitrogen carrier flow, and a silicon gas-phase product is obtained; and S4, performing feedback control. The radio frequency induction plasma torch is adopted for high-temperature pyrolysis, and it is ensured that silicon tetrachloride is completely decomposed to generate high-activity silicon-containing gas. The sodium citrate solution is used for dissolution and synchronous surface modification, and the strong coordination capability of citrate radicals is used for stabilizing silicon hydroxyl, so that the product is endowed with stable electronegativity. And in combination with a feedback regulation mechanism of online component and potential monitoring, accurate control of key quality attributes of a final product is realized, and the product consistency is ensured.

This application discloses a bipolar molecularly co-modified perovskite nanocrystal and its preparation method. After nucleation of CsPbBr3 nanocrystals, zinc bromide and 1-naphthalenesulfonic acid (NSA) are introduced for post-treatment, resulting in dual passivation and physical coating of defect states on the nanocrystal surface. Zinc bromide provides excess Br. ‑ Zn fills surface halogen vacancies. 2+ Occupy Pb 2+ Vacancy suppression of deep-level defects; NSA's sulfonic acid group -SO3 ‑ As strong coordination sites, they replace and firmly anchor weakly bound oleic acid / oleylamine ligands to the surface, and their aromatic ring structure stabilizes the surface through cation-π interactions. Zinc bromide and NSA work synergistically to achieve efficient and deep passivation of surface defect states of CsPbBr3 nanocrystals. Perovskite nanocrystals exhibit high photoluminescence quantum yield, narrow fluorescence peak, and uniform size distribution, and are stably dispersed in organic solvents for a long time. The ligands on the nanocrystal surface are firmly bound, improving optical and structural stability, and the process is simple and efficient.

This invention belongs to the fields of biomedical materials and colloid chemistry, and discloses a structurally remodeled egg yolk low-density lipoprotein biomimetic liposome and its application in regulating cholesterol metabolism. The method includes extracting and purifying natural egg yolk low-density lipoprotein; selectively removing endogenous cholesterol by adding β-cyclodextrin under alkaline conditions; adding a phytosterol ethanol solution to the cholesterol-removed low-density lipoprotein dispersion, followed by incubation and dialysis purification to obtain the biomimetic liposome. The obtained biomimetic liposome uses partially cholesterol-removed egg yolk low-density lipoprotein as its structural framework, with phytosterols embedded in its phospholipid monolayer and lipid core interface. This biomimetic liposome can inhibit cholesterol micelle formation, reduce cholesterol absorption, promote macrophage cholesterol efflux, and inhibit macrophage foam formation. It can be used to prepare cholesterol metabolism regulating materials, functional delivery systems, and dietary supplement products.

The present invention relates to nanostructures that, after in vivo administration, are excreted in the urine via the kidneys without being phagocytosed by macrophages and / or metabolized, and their use as pharmaceutical compositions. A nanostructure for in vivo administration according to the present invention comprises (i) a spherical core formed by crosslinking two or three dextran molecules with an average molecular weight of 10,000 Da or less using a crosslinker and (ii) a discontinuous shell with divalent or trivalent iron ions coordinationally bonded to crosslinker-derived hydrophilic groups on the surface of the spherical core; and (iii) a mass ratio of dextran to iron ranging from 100 : 2 to 100 : 10, with a crosslinker substitution ratio adjusted to 10% to 50% of the total number of functional groups on the dextran, while 20% to 50% of the crosslinker does not participate in crosslinking at the terminal end, resulting in the nanostructure having the charge ranging from -20 mV to 0 mV; (iv) wherein only 20% to 80% of the crosslinker-derived hydrophilic groups externally exposed on the surface of the spherical core bind iron ions, while the remainder do not bind iron ions and are exposed to an aqueous environment.

The invention discloses a fragrant pomelo peel essential oil compound preservative capable of improving the storage quality of prunus salicina, and belongs to the technical field of fruit preservation. The preservative is prepared from the following components in percentage by mass: 0.1 to 1.0 percent of fragrant pomelo peel essential oil, 0.5 to 2.0 percent of chitosan, 0.3 to 1.5 percent of modified white carbon black, 0.05 to 0.2 percent of antioxidant, 0.2 to 1.0 percent of glycerol, 0.1 to 0.5 percent of film-forming agent and the balance of deionized water. The modified white carbon black is prepared by step-by-step modification of a silane coupling agent, guar gum hydroxypropyl trimethyl ammonium chloride and sodium lignin sulfonate, can efficiently adsorb and slowly release essential oil, and enhances the compatibility with chitosan and the mechanical properties of a film layer. According to the preservative disclosed by the invention, a composite coating film is formed by dip-coating, so that water loss, browning and microbial decay after the prunus salicina is picked can be remarkably inhibited, the shelf life of the prunus salicina is prolonged to 12-15 days at normal temperature, and the preservative is suitable for large-scale storage and preservation of the prunus salicina.

This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a hyaluronic acid-modified co-supported nanoparticle, its preparation method, and its application. The nanoparticle has a core-shell structure, with the core being a coordination complex of zinc-doped Prussian blue and sinomenine hydrochloride, and the outer shell being a bovine serum albumin-hyaluronic acid conjugate. This invention improves the therapeutic effect on knee osteoarthritis.

The invention discloses a preparation method of salt-heat double-tolerant whey protein, which comprises the following steps: dispersing whey protein in water to obtain a solution A; the mass concentration of the protein in the solution A is 1-5%, and the pH is 7-9; performing ultrahigh pressure treatment on the solution A to obtain a solution B; the pressure of the ultrahigh pressure treatment is 300 to 600 MPa, and the time is 5 to 10 minutes; adjusting the pH value of the solution B to 4-5 to obtain a solution C; centrifuging the solution C, and recovering the precipitate; dispersing the precipitate in water, and adjusting the pH value to 6.0-7.0 to obtain a solution D; and drying the solution D to obtain the salt-heat double-tolerant whey protein. After being heated in a system containing NaCl or CaCl2, the salt-heat double-tolerant whey protein dispersion liquid (5%, w / w) still has good flowability. The salt-heat double-tolerant whey protein prepared by the invention can be used for preparing protein beverages or smokable gel rich in electrolyte.

The application discloses a ratio type fluorescent nanometer thermometer and a preparation method and application, and is prepared as follows: a polybasic saturated fatty acid is heated and melted into a liquid state, and after cooling, a solid is formed; the solid is ground into powder; the powder is heated and melted into a liquid to obtain A liquid; ACQ fluorescent molecules and an AIE molecule with an aggregation-induced emission property are dispersed in the A liquid, and after cooling, a solid is obtained; the solid is ground into powder to obtain powder B; the powder B is dissolved in dimethyl sulfoxide to prepare a B solution; the B solution is added dropwise into an aqueous solution of a non-intercalated surfactant; after the dropwise addition is completed, stirring is continued for 20-40 min; and excess non-intercalated surfactant is removed by dialysis; the thermometer has a temperature detection range of 25-48 DEG C, effectively covering the physiological temperature of 37 DEG C; the thermometer has excellent sensitivity and accuracy, and the maximum relative thermal sensitivity thereof in a water environment is as high as 63.66% / DEG C, which is much higher than that of a previously reported ratio type fluorescent nanometer thermometer.