274results about "X-ray constrast preparations" patented technology

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and / or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and / or dynamically identify one or more features, such as plaque and vessels, and / or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and / or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and / or quantified parameters.

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and / or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and / or dynamically identify one or more features, such as plaque and vessels, and / or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and / or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and / or quantified parameters.

In some aspects, the present disclosure pertains to a method of forming radiopaque crosslinked hydrogel particles comprising (a) mixing a reactive multi-arm polymer comprising a plurality of cyclic imide ester groups, a reactive multifunctional compound comprising a plurality of amino groups, and a radiocontrast agent under conditions in which a pH environment surrounding the reactive multi-arm polymer, the reactive multifunctional compound and the radiocontrast agent increases from an acidic pH to a basic pH, thereby forming a radiopaque hydrogel and (b) subjecting the hydrogel to a particle size reduction process, thereby forming the radiopaque crosslinked hydrogel particles. Other aspects of the present disclosure pertain to radiopaque crosslinked hydrogel particles formed from such methods, suspensions of such radiopaque crosslinked hydrogel particles, and medical supplies that contain such radiopaque crosslinked hydrogel particles.

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and / or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and / or dynamically identify one or more features, such as plaque and vessels, and / or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and / or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and / or quantified parameters.

The invention belongs to the technical field of radiotherapy sensitizers, and relates to a hafnium-titanium composite nano radiosensitizer as well as a preparation method and application thereof. The invention discloses a preparation method of a hafnium-titanium composite nano radiosensitizer, which comprises the following steps: (1) mixing a titanium-based metal frame compound Ti-MOF and hafnium-based oxide HfO2 with water according to a mass ratio of 2: 1-1: 2, putting the mixture into a reaction kettle, and carrying out hydrothermal reaction at 80-130 DEG C for 6-48 hours to obtain hafnium-titanium nanoparticles; and (2) dispersing the hafnium-titanium nanoparticles in the hydrophilic modification material solution, and stirring at room temperature for 6-48 hours to obtain the hafnium-titanium composite nano radiosensitizer. The invention also discloses application of the hafnium-titanium composite nano radiosensitizer in the field of imaging and preparation of medicines for treating colorectal cancer.

The present invention provides preparations of MSCs with important therapeutic potential. The MSC cells are non-primary cells with an antigen profile comprising less than about 1.25% CD45+ cells (or less than about 0.75% CD45+), at least about 95% CD105+ cells, and at least about 95% CD166+ cells. Optionally, MSCs of the present preparations are isogenic and can be expanded ex vivo and cryo-preserved and thawed, yet maintain a stable and uniform phenotype. Methods are taught here of expanding these MSCs to produce a clinical scale therapeutic preparations and medical uses thereof.

The invention belongs to the technical field of experiments and the field of anatomical research, and particularly relates to a self-developing vascular casting agent and a preparation method thereof. The invention discloses a preparation method of a self-developing vascular casting agent. The self-developing vascular casting agent is obtained by uniformly mixing iopromide, natural latex, II-type barium sulfate and pigment, wherein in parts by weight, the iopromide accounts for 30-40%; 25%-30% of natural latex; 40% of type II barium sulfate; and 5%-10% of pigment. The blood vessel casting agent developed by the invention is excellent in formula flowability (smooth perfusion), does not cause blockage, can avoid reverse osmosis of a capillary microenvironment, and realizes arteriovenous differentiated perfusion; and meanwhile, high-contrast development is realized, and complete coverage of capillary vessels is basically realized. The optimized blood vessel casting agent formula is completely cured (at room temperature) within 24 hours, the shrinkage rate is low, and blood vessel deformation is avoided.

The invention belongs to the technical field of biological medicine, and discloses an anti-CD39 nano antibody and application thereof. The anti-CD39 nano antibody has an amino acid sequence as shown in SEQ ID NO.1, 5, 9, 13, 17, 21 or 25. The anti-CD39 nano antibody of some examples has good antigen specificity, can be effectively combined with a target antigen CD39, and can effectively block or inhibit the hydrolysis of ATP (adenosine triphosphate) by the CD39, so that the depletion of T cells by a tumor microenvironment is effectively inhibited, and the curative effect of tumor immunotherapy is expected to be improved. The anti-CD39 nano antibody of some examples of the invention can further improve the curative effect of T cell immunotherapy related to CAR-T, TCR-T, TIL, TAL, NK, CIK and the like.

This disclosure relates to methods and materials for embolization of one or more blood vessels (e.g., one or more arteries). For example, hydrogel compositions for embolization of one or more blood vessels (e.g., one or more arteries) within a mammal (e.g., a human) are provided.

This invention provides a multifunctional nanodelivery system integrating gene delivery and CT tracking. The multifunctional nanodelivery system includes a gene delivery vector and an HGF plasmid gene loaded on the gene delivery vector; the gene delivery vector comprises gold nanoparticles coated with protamine sulfate. The gene delivery vector AuPS provided by this invention has excellent cell membrane transport and nuclear localization capabilities, enabling the HGF plasmid gene to efficiently enter cells and be expressed in the nucleus. The multifunctional nanodelivery system provided by this invention can be used for cell function regulation and tracking of therapeutic cells such as stem cells.

The present invention relates to injectable compositions. More particularly, the present disclosure relates to injectable, thermogelling hydrogel formulations comprising at least one antibiotic for relieving and / or treating low back pain.

An application for the EGT-AuNPs in preparing contrast agents and / or antioxidants is provided, where the EGT-AuNPs include gold nanoparticles (AuNPs), the AuNPs are connected to L-ergothioneine (EGT) by gold-sulfur bonds, and the antioxidants include medicines for preventing and / or treating acute kidney injury (AKI). EGT-AuNPs with antioxidant activity are designed and synthesized through the combination of the higher imaging contrast of gold and the antioxidant natural product EGT, and they are ultra-small AuNPs, which achieve the combination of CT imaging and antioxidant effects, and are suitable for renal imaging, particularly for the early diagnosis and treatment of AKI, realizing the integration of diagnosis and treatment, circumventing the toxicity of contrast agents present in the conventional nanomaterials, lowering the serum creatinine and urea nitrogen levels, and reducing the degree of renal tubular damage.

Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and / or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and / or dynamically identify one or more features, such as plaque and vessels, and / or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and / or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and / or quantified parameters.

The present invention relates to a process for preparing a compound corresponding to the formula, this process being characterized in that it comprises at least one oxidation step of sulfonated triphenylmethane of formula [Chem V] with a quinone selected from 1,4-benzoquinone, 1,2-benzoquinone, a dialkyl(C1-C4) 1,4-benzoquinone, a dialkyl(C1-C4) 1,2-benzoquinone, a monoalkyl(C1-C4) 1,4-benzoquinone, a monoalkyl(C1-C4) 1,2-benzoquinone. Novel crystalline form of Patent Blue, sodium salt.

The invention belongs to the technical field of angiographic contrast agents, and particularly relates to an angiographic contrast agent for corpses and a preparation method of the angiographic contrast agent. The angiographic contrast agent for the corpse is prepared from the following components in parts by mass: 20 to 35 parts of iodine-containing polymer, 30 to 50 parts of iodo-benzene ring compound, 90 to 150 parts of glycerol triacetate, 30 to 40 parts of dimer acid and 600 to 800 parts of liquid paraffin, the iodine-containing polymer is obtained by copolymerizing (methyl) C4-6 alkyl acrylate, polyethylene glycol diacrylate and an iodine-containing monomer, and the iodine-containing monomer is selected from at least one of 3-iodine-ethyl acrylate, 3-iodine-methyl acrylate and (methyl) iodobenzyl acrylate. The blood vessel contrast agent disclosed by the invention can realize an excellent blood vessel contrast effect on a corpse, can also obtain a relatively ideal contrast effect for a corpse with relatively long death time, and provides powerful support for the corpse work.

The application belongs to the technical field of material preparation, and relates to a bimodal functional imaging nanomaterial and a preparation method and application thereof. 1‑x Fe x Se2, wherein 0 < x < 1. The preparation method of the bimodal functional imaging nanomaterial comprises the following steps: stirring ferrous sulfate and cysteine in a solvent until uniform, then fully stirring bismuth salt, then adding sodium selenite to perform a heating reaction to obtain a bismuth iron selenium nanocomposite. The bismuth iron selenium nanocomposite provided by the application is uniform in size, regular in morphology, has good water phase dispersibility, and has the performance of simultaneously enhancing MRI imaging and CT imaging.

The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for imaging cancer-associated fibroblasts (CAFs) in the tumor microenvironment of a patient. The present teachings relate generally to method of making conjugates comprising a fibroblast activation protein (FAP) inhibitor.

The present application relates to the technical field of disease detection, and more particularly to a method for diagnosing and treating early atherosclerotic plaques based on multifunctional nanomaterial CeOx-P@PM, which comprises the following steps: S1: assembling CeOx with a MMP2 specific probe to form a CeOx-P compound; and S2: coating the CeOx-P compound with a biomimetic platelet membrane as a carrier to assemble CeOx-P@PM nanoparticles. The method for diagnosing and treating early atherosclerotic plaques based on multifunctional nanomaterial CeOx-P@PM has the excellent characteristics of efficient ROS removal, high bioavailability, lesion targeting, and dual-mode precise imaging, and will provide great help for the diagnosis and treatment of early atherosclerotic plaques in clinical practice.

This invention discloses a therapeutic molecule, nanoparticles, and their preparation method for locating and stabilizing atherosclerotic plaques. The therapeutic molecule is synthesized based on cholanonic acid and copper peptide, and the nanoparticles are formed by the self-assembly of the therapeutic molecule. The preparation method involves aldehyde modification of both ends of cholanonic acid and coupling it with copper peptide via a Schiff base reaction to obtain a therapeutic molecule with both diagnostic and therapeutic functions. The copper peptide structure in the therapeutic molecule serves as the hydrophilic segment, and the cholanonic acid structure serves as the hydrophilic segment, allowing it to further self-assemble into nanoparticles in water. These nanoparticles exhibit acid responsiveness and can disintegrate in the slightly acidic environment of atherosclerotic sites. The released copper peptide can stabilize plaques by promoting collagen secretion and inhibiting matrix metalloproteinase expression. Simultaneously, the X-ray imaging characteristics of cholanonic acid can be used to locate and diagnose the distribution of plaques, thus achieving integrated stabilization and localization of atherosclerotic plaques.

The invention discloses an LYPD3 specific binding polypeptide, and the amino acid sequence of the polypeptide is shown as SEQ ID NO.4-6. The polypeptide has excellent specificity and can be used for diagnosis and treatment of diseases with positive expression of LYPD3. In addition, the invention also discloses a polypeptide conjugate (PDC, Peptide Tug Conjugate) based on the polypeptide, the polypeptide conjugate (PDC) has a good treatment effect on various cancers positively expressed by LYPD3, and in addition, the polypeptide conjugate can be used for treatment of refractory tumors, especially tumors resistant to immunotherapy and / or chemotherapy.

Nanoparticles suitable for delivery of a cargo to a chondrocyte, and targeting peptides comprising a chondrocyte targeting sequence, are provided. Further provided are uses of the nanoparticles and targeting peptides, for example, in treating a joint or cartilage disease or disorder.

The present invention relates to a compound of the following formula (A) for use mainly as a radiopaque monomer. The present invention further relates to radiopaque embolization microspheres based on at least 20% - 90% hydrophilic monomer, 5% - 50% compound of formula (A), 1% - 15% non - biodegradable hydrophilic cross - linking monomer, and - 0.1% - 10% migrating agent. The present invention also relates to a pharmaceutical composition comprising at least one embolization microsphere according to the invention, preferably with a pharmaceutically acceptable carrier for parenteral administration. The present invention further relates to a kit comprising a pharmaceutical composition according to the invention with a pharmaceutically acceptable carrier for parenteral administration and injection means. TIFF2025521863000019.tif20128

To provide a system, a method, and a device for medical image analysis, diagnosis, risk stratification, decision making and / or disease tracking.SOLUTION: A system, a device, and a method are configured to analyze non-invasive medical images of a subject to automatically and / or dynamically identify one or more features, such as plaque and vessels, and / or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and / or the like. The system, device, and method are further configured to generate one or more assessments of plaque-based diseases from raw medical images by using one or more of the identified features and / or quantified parameters.SELECTED DRAWING: Figure 2A

The application discloses a silk fibroin nanocage and application thereof. The silk fibroin nanocage is self-assembled from silk fibroin fragments with a specific molecular weight distribution, and the size of the nanocage can be regulated by selecting different molecular weight fragments. The nanocage is used as a template to guide the reaction of metal ions and a sulfur source in a strong alkali environment, so that metal sulfide nanoparticles with a core-shell structure can be prepared, and the particle size can be controlled in the range of 5-50 nm. By selecting nanocage templates with different molecular weights, the functions of the nanoparticles can be directionally optimized, so that the nanoparticles are respectively applicable to efficient photothermal therapy, high-contrast medical imaging, or photothermal immune synergistic therapy and tissue repair. The application realizes universal and accurate regulation of the size and function of nanomaterials from a template source, and the nanoparticle products have good biocompatibility and excellent performance, and have wide application prospects in the fields of tumor diagnosis and treatment, antibacterial and anti-inflammatory, and regenerative medicine.

The invention discloses a manganese phenol network coated polyethyleneimine stabilized polypyrrole nanoparticle and application thereof, and belongs to the technical field of biological medicine. Hyperbranched polyethyleneimine is used as a carrier, polypyrrole and Mn < 2 + > are integrated in a functionalized PEI.NH2 nano system, PPy nanoparticles are stabilized through the functionalized PEI.NH2, then gold nanoparticles are wrapped in the functionalized PEI.NH2, and finally the nano composite system is wrapped with a tannic acid-manganese ion network through a one-step assembly method. The preparation method comprises the following steps: constructing a PEI.NH2 stable PPy nanoparticle Au-PPy PPSNs (at) TMn coated with a manganese phenol network; according to the Au-PPy PPSNs (at) TMn disclosed by the invention, CDT / PTT synergistic treatment and CT / MR (Computed Tomography / Magnetic Resonance) bimodal imaging of cancer cells can be realized.

In some aspects, systems for forming hydrogels are provided that comprises (i) a reactive multi-arm polymer that comprises three or more polymer arms linked to a core region, at least three of the polymer arms comprising a reactive moiety comprising a cyclic-imidyl-oxycarbonyl- end group and (ii) a polyamino compound comprising at least two amino (—NH2) groups, wherein the reactive multi-arm polymer and the polyamino compound react to form crosslinked hydrogels that do not contain ester groups and have long-term stability in vivo. In other aspects, the present disclosure pertains to crosslinked hydrogels formed from such systems and methods of treatment using such systems.

In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core region, a plurality of polymer arms linked to the core region, at least three of the polymer arms each comprising a hydrophilic polymer segment and an amino-alcohol residue that is attached to the hydrophilic polymer segment through an ether group, an electrophilic group attached to each amino-alcohol residue through a linkage that comprises a hydrolysable ester group, and a residue of a carboxylic-acid-containing iodinated molecule attached to each amino-alcohol residue through a linkage comprising an amide group. Other aspects of the present disclosure pertain to systems for forming hydrogels that are based on such multi-arm polymers, to crosslinked products that are formed from such systems, and to methods of treatment that use such systems.