57results about How to "Improve clearance rate" patented technology

Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.

Described herein are methods and compositions for treating certain retinol-related diseases and conditions by modulation of transthyretin (TTR) and retinol binding protein (RBP) availability in the subject. For example, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-related macular degeneration and/or dystrophies, metabolic disorders, idiopathic intracranial hypertension, hyperostosis, and protein misfolding and aggregation diseases. The compositions disclosed may be used as single agent therapy or in combination with other agents or therapies. In addition, described herein are methods and assays for selecting appropriate agents that can modulate the TTR and RBP availability in a subject.

Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and covalent complexes having target cell specificity are provided. Kits for conjugating radionuclides and other metals to peptide coordination complexes are also provided.

A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin, β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.

Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for which expression is statistically different between control and calorie restricted animals has demonstrated that specific genes are preferentially expressed during calorie restriction. Screening for interventions which produce the same expression profile will provide interventions that increase life span. In a further aspect, it has been discovered that test animals on a calorie restricted diet for a relatively short time have a similar gene expression profile to test animals which have been on a long term calorie restricted diet.

The invention provides a photocatalyst type formaldehyde scavenger to solve the problems that in the prior art, the formaldehyde removing rate is low, secondary pollution is prone to being caused, and the cost is high. The photocatalyst type formaldehyde scavenger is composed of 1%-10% of a nano silver paste solution, 1%-15% of photocatalyst, 0%-5% of an N-lauroyl-L-glutamic acid surfactant, 0%-5% of polyethylene glycol, 1%-8% of a formaldehyde trapping agent, and the balance deionized water. The photocatalyst can be an anatase nanometer titania colloidal solution. The obtained photocatalyst type formaldehyde scavenger has the advantages of being high in formaldehyde removing rate, free of secondary pollution, environmentally friendly, economical and practical, and meanwhile, the photocatalyst type formaldehyde scavenger can be used for scavenging volatile organic compounds such as benzene, methylbenzene and xylene.

An anticancer Chinese medicine in the form of injection, dripping pill and capsule is prepared from astragalus root, brucea fruit, zedoary oil, coix seed, and optional others. Its preparing process is also disclosed.

The invention discloses an astronaut long flight anti-fatigue chewable tablet and a preparation method thereof. The chewable tablet is prepared from 30%-50% of pine nut protein powder, 4%-6% of blueberry freeze-dried powder, 2%-4% of wolfberry powder, 3%-5% of kiwi powder, 3%-5% of indigo fruit powder, 3%-5% of Schisandra fruit powder, 1%-2% of glutamine, 8%-15% of beta-cyclodextrin, 2%-5% of buckwheat starch, 10%-15% of xylitol, 2%-4% of citric acid and 5%-10% of fructooligosaccharides. The method is characterized in that pine nut protein is used as raw materials, and the chewable tablet with anti-fatigue effect is prepared on the basis of ensuring the nutritional balance on the ratio of the raw materials. The size of the tablet is designed according to the size of the mouth, to make the tablet easy to eat, good in taste and the like. The tablet can be used for space station astronauts, aviation pilots, field troops, navigation, submarines and other activities, can also be used for emergency relief, special forces, travel, overtime working and other people, to supplement consumed energy substance of the body in time, thereby rapidly relieving fatigue and restoring strengths, relieving mental fatigue, and improving the endurance and work efficiency in the fatigue state.

The invention discloses an ash clearing device for a boiler flue and relates to the field of power supplying boilers. The device comprises a base, and a transmission lead screw vertically and rotationally connected to the middle portion of the base; the outer wall of the transmission lead screw is sleeved with a nut, and the transmission lead screw and the nut form a lead screw pair; the device further comprises an installing ring, and a pair of supporting plates are arranged in front of the inner wall of the installing ring and the outer wall of the nut; a circle of scraping plate used for tightly abutting against the interior of the flue is arranged at the outer edge position of the upper end face of the installing ring, and the upper end face of the installing ring is further provided with a circle of containing groove; a pair of guiding rods are vertically arranged on the base; and the pair of supporting plates are each provided with a guiding hole for the corresponding guiding rodto penetrate through. The ash clearing device for the boiler flue has the following beneficial effects that by arranging the high-automatic device to achieve automatic movement of the scraping plate,the scraping plate is utilized for scraping and stripping oil stains on the inner wall of the flue, the clearing effect of the inner wall of the flue is effectively improved, so that the ash clearingprocess of the flue is more thorough, and the cleanness degree of the inner wall of the flue is improved.

The invention discloses a composition with functions of enhancing immunity and relieving physical fatigue. The composition is mainly prepared from the following active components: a coenzyme Q10 and ginseng. The composition can also comprise the following active components: longstamen onion bulb and spina date seeds. The invention also discloses an application of the composition in preparing health products with the functions of enhancing immunity and relieving physical fatigue. The composition can be prepared into dosage forms such as soft capsules, capsules, tablets, granules, powder, effervescing agents, mixtures or oral liquids and the like by adopting a modern preparation process way. The composition disclosed by the invention is characterized in that the health functions of enhancing immunity and relieving physical fatigue can be achieved by combining conventional Chinese herbal medicine characteristics with modern energy metabolism researches by virtue of various routes and different levels.

The invention discloses a humanized anti-TPBG antibody, a preparation method thereof, a conjugate thereof and application thereof. The humanized anti-TPBG antibody comprises (a) a framework region comprising residues of a human antibody framework region; and (b) one or more CDRs in a light chain variable region shown as SEQ ID NO.4 or 8 or one or more CDRs in a heavy chain variable region shown asSEQ ID NO.2 or 6. The humanized anti-TPBG antibody has a binding affinity of at least about 1 * 10<-7> M to about 1 * 10<-12>M for a human TPBG antigen. The humanized anti-TPBG antibody is conjugatedwith a small molecule compound such as MC-MMAF to obtain the conjugate which is effective in cytotoxic killing effect on TPBG positive cells. Therefore, the humanized anti-TPBG antibody is used for preparing an antibody cross-linking drug, which can effectively kill tumor cells and treat tumors.

Disclosed are compounds, compositions, systems, and methods useful for treating disease (such as cancer and tumors), or binding, detecting, and affecting compounds, compositions, cells, tissues, and organs, where the compounds, compositions, systems, and methods include or involve toxic compounds and where the toxic effect of the compounds, compositions, systems, and methods is reduced by providing a cleavage site to facilitate separation of the toxic component from other components of the compound, composition, or system. Preferably the system is a composition delivery system comprising or using a composition as disclosed herein. In some forms, the cleavage of the composition delivers a therapeutic agent and avoids organ damage by the composition.

The invention relates to a fructus lycii health maintenance noodle and a preparation method thereof. The fructus lycii health maintenance noodle is prepared from the following raw materials in parts by weight: 100 to 200 parts of flour, 10 to 20 parts of fructus lycii powder, 1.5 to 3 parts of radix astragali seu hedysari powder, 0.6 to 1.2 parts of rhizoma polygonati powder, 1.5 to 3 parts of table salt and 20 to 40 parts of water. The fructus lycii health maintenance noodle contains varieties of ingredients which can tonify spleen, nourish stomach and improve immunity; when the fructus lyciihealth maintenance noodle is eaten for a long time, the effects of tonifying qi and blood, improving appetite and building body are achieved; furthermore, the fructus lycii health maintenance noodleis prepared by a mechanical technology, a noodle production efficiency is high, and comprehensive production cost is low.