57results about How to "Improve clearance rate" patented technology

Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and covalent complexes having target cell specificity are provided. Kits for conjugating radionuclides and other metals to peptide coordination complexes are also provided.

Described herein are methods and compositions for treating certain retinol-related diseases and conditions by modulation of transthyretin (TTR) and retinol binding protein (RBP) availability in the subject. For example, the methods and compositions provide for therapeutic agents for the treatment and / or prevention of age-related macular degeneration and / or dystrophies, metabolic disorders, idiopathic intracranial hypertension, hyperostosis, and protein misfolding and aggregation diseases. The compositions disclosed may be used as single agent therapy or in combination with other agents or therapies. In addition, described herein are methods and assays for selecting appropriate agents that can modulate the TTR and RBP availability in a subject.

Methods and compositions for medical imaging, evaluating intracellular processes and components, radiotherapy of intracellular targets, and drug delivery by the use of novel cell membrane-permeant peptide conjugate coordination and covalent complexes having target cell specificity are provided. Kits for conjugating radionuclides and other metals to peptide coordination complexes are also provided.

The method is used for preventing or treating an amyloid-β related disease in a subject. The method comprises administering to a subject in need thereof an effective amount of a first agent that prevents or treats amyloid-β related disease, and a second agent that is (i) a peptide or peptidomimetic that modulates amyloid-β fibril formulation or induces a prophylactic or therapeutic immune response against amyloid-β fibril formulation, or (ii) an immune system modulator that pi-events or inhibits amyloid-β fibril formulation.

A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin, β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.

An enzymatic method is provided for treating ophthalmic disorders of the mammalian eye. Prevention of neovascularization and the increased rate of clearance from the vitreous of materials toxic to retina is accomplished by administering an amount of hyaluronidase effective to liquefy the vitreous humor of the treated eye without causing toxic damage to the eye. Liquefaction of the vitreous humor increases the rate of liquid exchange from the vitreal chamber. This increase in exchange removes those materials and conditions whose presence causes ophthalmological and retinal damage.

Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for which expression is statistically different between control and calorie restricted animals has demonstrated that specific genes are preferentially expressed during calorie restriction. Screening for interventions which produce the same expression profile will provide interventions that increase life span. In a further aspect, it has been discovered that test animals on a calorie restricted diet for a relatively short time have a similar gene expression profile to test animals which have been on a long term calorie restricted diet.

The invention provides a photocatalyst type formaldehyde scavenger to solve the problems that in the prior art, the formaldehyde removing rate is low, secondary pollution is prone to being caused, and the cost is high. The photocatalyst type formaldehyde scavenger is composed of 1%-10% of a nano silver paste solution, 1%-15% of photocatalyst, 0%-5% of an N-lauroyl-L-glutamic acid surfactant, 0%-5% of polyethylene glycol, 1%-8% of a formaldehyde trapping agent, and the balance deionized water. The photocatalyst can be an anatase nanometer titania colloidal solution. The obtained photocatalyst type formaldehyde scavenger has the advantages of being high in formaldehyde removing rate, free of secondary pollution, environmentally friendly, economical and practical, and meanwhile, the photocatalyst type formaldehyde scavenger can be used for scavenging volatile organic compounds such as benzene, methylbenzene and xylene.

The invention discloses an electric spark liquid atomization nozzle and belongs to the technical field of electric spark machining. The electric spark liquid atomization nozzle comprises a nozzle main body. The nozzle main body comprises a hollow tube used for installing an electrode and is provided with a sealed upper end cover and an open lower end. The hollow tube penetrates through the nozzle main body and extends to an opening formed in the lower end. The nozzle main body is internally provided with an annular partition plate which divides the nozzle main body into a liquid chamber and a gas chamber. The lower end of each liquid inlet is provided with a first annular groove. The lower end of each gas inlet is provided with a second annular groove. A mixing chamber is arranged at an opening in the lower end of the liquid chamber and an opening in the lower end of the gas chamber. Compared with the prior art, the electric spark liquid atomization nozzle can improve the atomization state and then change the discharge gap and the discharge channel configuration, so that the workpiece surface quality is improved, the clearance rate of electric corrosion products is accelerated, the machining capacity of existing electric spark machine tools is further excavated, and the electric spark machining technology is efficient.

An anticancer Chinese medicine in the form of injection, dripping pill and capsule is prepared from astragalus root, brucea fruit, zedoary oil, coix seed, and optional others. Its preparing process is also disclosed.

The invention discloses an astronaut long flight anti-fatigue chewable tablet and a preparation method thereof. The chewable tablet is prepared from 30%-50% of pine nut protein powder, 4%-6% of blueberry freeze-dried powder, 2%-4% of wolfberry powder, 3%-5% of kiwi powder, 3%-5% of indigo fruit powder, 3%-5% of Schisandra fruit powder, 1%-2% of glutamine, 8%-15% of beta-cyclodextrin, 2%-5% of buckwheat starch, 10%-15% of xylitol, 2%-4% of citric acid and 5%-10% of fructooligosaccharides. The method is characterized in that pine nut protein is used as raw materials, and the chewable tablet with anti-fatigue effect is prepared on the basis of ensuring the nutritional balance on the ratio of the raw materials. The size of the tablet is designed according to the size of the mouth, to make the tablet easy to eat, good in taste and the like. The tablet can be used for space station astronauts, aviation pilots, field troops, navigation, submarines and other activities, can also be used for emergency relief, special forces, travel, overtime working and other people, to supplement consumed energy substance of the body in time, thereby rapidly relieving fatigue and restoring strengths, relieving mental fatigue, and improving the endurance and work efficiency in the fatigue state.

Described herein are methods and compositions for treating certain retinol-related diseases and conditions by modulation of transthyretin (TTR) and retinol binding protein (RBP) availability in the subject. For example, the methods and compositions provide for therapeutic agents for the treatment and / or prevention of age-related macular degeneration and / or dystrophies, metabolic disorders, idiopathic intracranial hypertension, hyperostosis, and protein misfolding and aggregation diseases. The compositions disclosed may be used as single agent therapy or in combination with other agents or therapies. In addition, described herein are methods and assays for selecting appropriate agents that can modulate the TTR and RBP availability in a subject.

The invention discloses an ash clearing device for a boiler flue and relates to the field of power supplying boilers. The device comprises a base, and a transmission lead screw vertically and rotationally connected to the middle portion of the base; the outer wall of the transmission lead screw is sleeved with a nut, and the transmission lead screw and the nut form a lead screw pair; the device further comprises an installing ring, and a pair of supporting plates are arranged in front of the inner wall of the installing ring and the outer wall of the nut; a circle of scraping plate used for tightly abutting against the interior of the flue is arranged at the outer edge position of the upper end face of the installing ring, and the upper end face of the installing ring is further provided with a circle of containing groove; a pair of guiding rods are vertically arranged on the base; and the pair of supporting plates are each provided with a guiding hole for the corresponding guiding rodto penetrate through. The ash clearing device for the boiler flue has the following beneficial effects that by arranging the high-automatic device to achieve automatic movement of the scraping plate,the scraping plate is utilized for scraping and stripping oil stains on the inner wall of the flue, the clearing effect of the inner wall of the flue is effectively improved, so that the ash clearingprocess of the flue is more thorough, and the cleanness degree of the inner wall of the flue is improved.

The invention discloses a composition with functions of enhancing immunity and relieving physical fatigue. The composition is mainly prepared from the following active components: a coenzyme Q10 and ginseng. The composition can also comprise the following active components: longstamen onion bulb and spina date seeds. The invention also discloses an application of the composition in preparing health products with the functions of enhancing immunity and relieving physical fatigue. The composition can be prepared into dosage forms such as soft capsules, capsules, tablets, granules, powder, effervescing agents, mixtures or oral liquids and the like by adopting a modern preparation process way. The composition disclosed by the invention is characterized in that the health functions of enhancing immunity and relieving physical fatigue can be achieved by combining conventional Chinese herbal medicine characteristics with modern energy metabolism researches by virtue of various routes and different levels.

The invention discloses an electric spark liquid atomizing nozzle and belongs to the technical field of electric spark machining. The electric spark liquid atomizing nozzle comprises a nozzle body. The nozzle body comprises a hollow pipe for installation of an electrode. The nozzle body is provided with a sealed upper end cover and an open lower end. The hollow pipe penetrates the nozzle body and stretches to openings formed in the lower end. An annular partition is arranged in the nozzle body to divide the nozzle body into a liquid chamber and a gas chamber. A liquid inlet and a gas inlet are formed in the upper end cover, and mixing chambers are arranged at the openings in the lower ends of the liquid chamber and the gas chamber. Compared with the prior art, the atomization state can be improved, then the discharge gap and discharge channel configuration is changed, the surface quality of a workpiece is improved, the removal rate of electric corrosion products is increased, the machining capacity of an existing electric spark machine tool is further mined, and high efficiency of the electric spark machining technology is achieved.

The invention relates to an extract product capable of preventing oxidation, delaying aging, and nourishing heart and cerebral vessels, and a preparation method thereof. According to the preparation method, a grape extract and a mixed fruit powder are prepared firstly, and are mixed with yeast for fermentation, after metabolism of yeast, organic conversion of resveratrol in the grape extract, andanthocyanidin and a plurality of trace elements in the mixed fruit powder is realized, so that adsorption on nutrients is improved, and the biological value is increased. It is confirmed by animal experiments that the extract product is capable of prolonging mouse life time and rat loaded swimming time obviously, reducing blood urea nitrogen content, reducing blood lactic acid accumulation, and increasing hepatic glycogen content, possesses obvious anti-fatigue activity, is capable of increasing the activity of superoxide dismutase in rat serum, and accelerating malonaldehyde removing rate, and possesses obvious anti-oxidation activity. The extract product is prepared from pure natural materials, no chemical raw material is added, no toxic or side effect is caused by long term eating. Theextract product is suitable for fatigable people, people high in cholesterol content, and people with long term smoking and drinking habits.

The invention discloses a humanized anti-TPBG antibody, a preparation method thereof, a conjugate thereof and application thereof. The humanized anti-TPBG antibody comprises (a) a framework region comprising residues of a human antibody framework region; and (b) one or more CDRs in a light chain variable region shown as SEQ ID NO.4 or 8 or one or more CDRs in a heavy chain variable region shown asSEQ ID NO.2 or 6. The humanized anti-TPBG antibody has a binding affinity of at least about 1 * 10<-7> M to about 1 * 10<-12>M for a human TPBG antigen. The humanized anti-TPBG antibody is conjugatedwith a small molecule compound such as MC-MMAF to obtain the conjugate which is effective in cytotoxic killing effect on TPBG positive cells. Therefore, the humanized anti-TPBG antibody is used for preparing an antibody cross-linking drug, which can effectively kill tumor cells and treat tumors.

Disclosed are compounds, compositions, systems, and methods useful for treating disease (such as cancer and tumors), or binding, detecting, and affecting compounds, compositions, cells, tissues, and organs, where the compounds, compositions, systems, and methods include or involve toxic compounds and where the toxic effect of the compounds, compositions, systems, and methods is reduced by providing a cleavage site to facilitate separation of the toxic component from other components of the compound, composition, or system. Preferably the system is a composition delivery system comprising or using a composition as disclosed herein. In some forms, the cleavage of the composition delivers a therapeutic agent and avoids organ damage by the composition.

A health and fitness management system is provided that has a health and fitness application operating, e.g., on a smart phone, that can wirelessly communicate with an activity module worn on the user which has a motion sensor, e.g., an accelerometer. The application accepts food and weight inputs (e.g., from the smart phone) and user activity units (e.g., from the activity unit) and develops a user intrinsic metabolism. The application includes fitness arc and health quotient graphical indicators that guide the user on health and fitness activities.

A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin,β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.

The invention provides a composition with a function of enhancing immunity, and is characterized in that the composition is prepared by proportioning of any four or more of fructus ligustri lucidi, herba ecliptae, radix astragali, codonopsis pilosula and poria cocos. The medicinal materials of the composition complement each other, and can be used as health care products or food for long-term administration, and as a good medicine for curing diseases. Pharmacological experiments show that the composition can improve the body fluid immune function and enhance mice monocyte-macrophage immune functions by increasing the removing rate of carbon particles in mice, and has a significant effect on enhancing immunity.

The invention relates to zeolite composition which is prepared from zeolite, dolomite, leguminous-plant radix puerariae and cactaceae-plant cactus, wherein the weight percentage of the zeolite in themedicine composition is 70% to 85%, the weight percentage of the dolomite in the composition is 5% to 10%, the weight percentage of the leguminous-plant radix puerariae in the composition is 10% to 20%, and the weight percentage of the cactaceae-plant cactus in the composition is 5% to 10%; optimally, a weight ratio of the zeolite to the dolomite to the leguminous-plant radix puerariae to the cactaceae-plant cactus is 75% to 5% to 15% to 5%; the zeolite is natural clinoptilolite.

The invention discloses a preparation method of an antibacterial hollow fiber membrane for treating uremia. The preparation method of the antibacterial hollow fiber membrane comprises the following steps of (1) modification treatment of polyethersulfone; (2) preparation of mesoporous silicon loaded nano silver; (3) preparation of inner and outer layer casting solutions; and (4) dry jet-wet spinning for preparation of the antibacterial hollow fiber membrane. The prepared antibacterial hollow fiber membrane is the antibacterial hollow fiber membrane which can be used for treating uremia. The hollow fiber membrane prepared by the invention has the advantages of high safety, simple preparation operation and low cost, and can be applied to hemodialysis of uremia. The open porous structure of aninner layer of the hollow fiber membrane prepared by the invention selectively enables the uremic toxin to pass through, and the structure and the charge recognition site in the outer layer can selectively bind the toxin, thereby effectively removing the uremic toxin. Meanwhile, the silver-loaded mesoporous silicon in the outer layer can release a trace amount of silver ions into the blood and dialysate to achieve the antibacterial effect.

The invention relates to a fructus lycii health maintenance noodle and a preparation method thereof. The fructus lycii health maintenance noodle is prepared from the following raw materials in parts by weight: 100 to 200 parts of flour, 10 to 20 parts of fructus lycii powder, 1.5 to 3 parts of radix astragali seu hedysari powder, 0.6 to 1.2 parts of rhizoma polygonati powder, 1.5 to 3 parts of table salt and 20 to 40 parts of water. The fructus lycii health maintenance noodle contains varieties of ingredients which can tonify spleen, nourish stomach and improve immunity; when the fructus lyciihealth maintenance noodle is eaten for a long time, the effects of tonifying qi and blood, improving appetite and building body are achieved; furthermore, the fructus lycii health maintenance noodleis prepared by a mechanical technology, a noodle production efficiency is high, and comprehensive production cost is low.