Preparation method of antibacterial hollow fiber membrane for treating uremia

A fiber membrane and hollow technology, which is applied in the field of fiber membrane materials, can solve the problems of difficulty in solving pH, electrolyte acid-base balance, high treatment cost, low clearance rate of uremic protein-bound toxoid, etc., and achieves low cost and improved clearance. The effect of speed, simple preparation and operation

Active Publication Date: 2019-05-14
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the above blood purification methods are combined with hemoadsorption or hemodialysis and hemoperfusion, which is difficult to solve the problems of pH and electrolyte acid-base balance, or the treatment cost is relatively high
These prior art reports all have a low clearance rate of uremic protein-bound toxoid, which is the main cause of clinical complications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Weigh 200g of polyethersulfone, dissolve it with 300mL of concentrated sulfuric acid, place it in a 250mL three-necked bottle, and stir to dissolve the polyethersulfone. After being uniformly dissolved, slowly add 9 mL of chlorosulfonic acid dropwise at 25°C with a stirring speed of 600 rpm, react for 4 hours, rinse with distilled water until neutral, and then dry at 80°C for 12 hours to obtain sulfonated polyethersulfone.

[0059] Dissolve 150g of sulfonated polyethersulfone in 225mL of dichloromethane, add 110mL of 8% 2-(N-morpholino)-ethanesulfonic acid and 80mL of 0.8% ethyl-hydrochloride at 25°C and 600rpm stirring speed 3-(Dimethylchloropropyl)carbodiimide and 90g of ethylenediamine were reacted for 5h, rinsed with distilled water until neutral and then dried at 70°C for 12h to obtain aminated polyethersulfone.

[0060] A silver nitrate aqueous solution with a concentration of 1.0% was prepared; 3.0 g of mesoporous silicon was ultrasonically dispersed in 300 mL of...

Embodiment 2

[0065] Weigh 250g of polyethersulfone, dissolve it with 250mL of concentrated sulfuric acid, place it in a 250mL three-necked bottle, and stir to dissolve the polyethersulfone. After dissolving evenly, slowly add 5mL of chlorosulfonic acid dropwise at 20°C with a stirring speed of 450rpm, react for 5h, rinse with distilled water until neutral, and then dry at 70°C for 8h to obtain sulfonated polyethersulfone.

[0066] Dissolve 200g of sulfonated polyethersulfone in 160mL of dichloromethane, add 80mL of 9% 2-(N-morpholino)-ethanesulfonic acid and 90mL of 0.3% ethyl-hydrochloride at 5°C and 300rpm stirring speed 3-(Dimethylchloropropyl)carbodiimide and 80g of ethylenediamine were reacted for 4h, rinsed with distilled water until neutral, and then dried at 70°C for 8h to obtain aminated polyethersulfone.

[0067] A silver nitrate aqueous solution with a concentration of 2.0% was prepared; 5.0 g of mesoporous silicon was ultrasonically dispersed in 250 mL of silver nitrate aqueous...

Embodiment 3

[0072] Weigh 300g of polyethersulfone, dissolve it with 450mL of concentrated sulfuric acid, place it in a 250mL three-necked bottle, and stir to dissolve the polyethersulfone. After dissolving evenly, slowly add 13.5mL chlorosulfonic acid dropwise at 15°C with a stirring speed of 300rpm, react for 2h, rinse with distilled water until neutral, and then dry at 80°C for 10h to obtain sulfonated polyethersulfone.

[0073] Dissolve 200g of sulfonated polyethersulfone in 300mL of dichloromethane, add 90mL of 16% 2-(N-morpholino)-ethanesulfonic acid and 110mL of 0.55% ethyl-hydrochloride at 30°C and 400rpm stirring speed 3-(Dimethylchloropropyl)carbodiimide and 90g of ethylenediamine were reacted for 3h, rinsed with distilled water until neutral, and then dried at 80°C for 12h to obtain aminated polyethersulfone.

[0074] A silver nitrate aqueous solution with a concentration of 1.5% was prepared; 4.0 g of mesoporous silicon was ultrasonically dispersed in 200 mL of silver nitrate a...

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Abstract

The invention discloses a preparation method of an antibacterial hollow fiber membrane for treating uremia. The preparation method of the antibacterial hollow fiber membrane comprises the following steps of (1) modification treatment of polyethersulfone; (2) preparation of mesoporous silicon loaded nano silver; (3) preparation of inner and outer layer casting solutions; and (4) dry jet-wet spinning for preparation of the antibacterial hollow fiber membrane. The prepared antibacterial hollow fiber membrane is the antibacterial hollow fiber membrane which can be used for treating uremia. The hollow fiber membrane prepared by the invention has the advantages of high safety, simple preparation operation and low cost, and can be applied to hemodialysis of uremia. The open porous structure of aninner layer of the hollow fiber membrane prepared by the invention selectively enables the uremic toxin to pass through, and the structure and the charge recognition site in the outer layer can selectively bind the toxin, thereby effectively removing the uremic toxin. Meanwhile, the silver-loaded mesoporous silicon in the outer layer can release a trace amount of silver ions into the blood and dialysate to achieve the antibacterial effect.

Description

technical field [0001] The invention relates to a fiber membrane material, in particular to a preparation method of an antibacterial hollow fiber membrane used for treating uremia. Background technique [0002] Chronic renal failure refers to a clinical syndrome composed of a series of symptoms and metabolic disorders caused by various kidney diseases leading to progressive and irreversible decline in renal function until the loss of function, referred to as chronic renal failure. The end stage of chronic renal failure is what is often called uremia. Uremia is not an independent disease, but a clinical syndrome shared by various advanced kidney diseases. It is a syndrome composed of a series of clinical manifestations when chronic renal failure enters the terminal stage. It is related to uremic toxins in the body. are closely related to retention. Renal failure can accelerate atherosclerosis. Once the arteries are blocked, it will cause many diseases, such as cardiovascula...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/08B01D67/00B01D71/68B01J20/28A01N59/16A61M1/16
Inventor 许为康顾珩刘群峰
Owner GUANGDONG PROV MEDICAL INSTR INST
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