66 results about "Trace Amounts" patented technology

This invention discloses a rapid mass spectrometry method and kit for the simultaneous detection of multiple components in body fluids, belonging to the field of biological detection and identification technology. It can rapidly detect trace compounds such as drugs and biomarkers in complex biological samples. This kit mainly utilizes loaded functional materials to achieve extraction and enrichment of target analytes and is equipped with a quick connector for coupling with a detector to achieve rapid detection. Compared with traditional methods, the significant advantages of the method established by this kit are that it does not require complex sample pretreatment, allows for micro-quantitative sampling, requires small sample volumes, facilitates convenient storage of biological samples, is easy to operate, does not require specialized technical personnel, and enables rapid on-site detection when coupled with portable mass spectrometry. This kit has been successfully used for the detection of quinine, procainamide hydrochloride, atenolol, and nortriptyline in complex samples such as blood and serum, and has significant clinical and economic value.

The invention discloses a double-layer detachable purification and enrichment device and a use method thereof, and relates to the technical field of sample analysis. The device comprises an enrichment column, a purification column and a needle head, the enriching column is detachably connected with the purifying column; as required, the needle head is detachably connected with the enriching column or the purifying column; wherein the enrichment column is in an injector shape, and a piston, a first filter disc, an enrichment material and a second filter disc are sequentially arranged in a cavity in the enrichment column from top to bottom; the piston moves up and down in the cavity, the first filter disc, the enrichment material and the second filter disc are arranged at the bottom in the cavity, and the enrichment material is filled in an interlayer between the first filter disc and the second filter disc and is fixed; a third filter disc, a purification material and a fourth filter disc are arranged in the purification column; and the purification material is filled in an interlayer between the third filter disc and the fourth filter disc and is fixed. The device integrates the processes of sampling, purification, enrichment, elution, sample loading and the like, and can realize rapid purification, enrichment and elution of trace target objects in a solution sample.

The utility model discloses a portable traditional Chinese medicine olfactory diagnosis instrument, which comprises a sample collection device, a gas enrichment device, a mass spectrometer, a data processor and a display, the mass spectrometer is sequentially connected with the data processor and the display, the gas enrichment device is test paper with an enrichment reagent encapsulating nano-metal particles, the enrichment efficiency is effectively improved, and the detection accuracy is improved. Therefore, the detection sensitivity and accuracy of the mass spectrometer are improved; the device is provided with the ion trap mass spectrometer, has the characteristics of high detection speed, high resolution and high sensitivity, and has performance advantages in qualitative and trace analysis aspects; and due to small volume and strong portability, the device can be conveniently integrated into portable or field detection equipment, can be used for auxiliary diagnosis of heart failure and asthma, and also has great clinical application value in the aspects of disease evolution and disease prognosis evaluation.

This invention discloses a method for enhancing the terahertz absorption spectrum of materials. The method uses a terahertz time-domain spectroscopy system to measure the material spectrum, calculates the material's transfer function, amplitude, and phase using the acquired reference signal and sample signal, fits the material's absorption spectrum by constructing a multi-Gaussian function model, and enhances the absorption spectrum through a coefficient enhancement factor. This strengthens the ability to identify minute differences in the terahertz spectrum and improves the ability of terahertz spectroscopy to distinguish substances with similar properties, similar compositions, and trace amounts.

The application discloses a raw material medicine trace heavy metal ion detection method and system based on a micro-fluidic chip, relates to the technical field of micro-fluidic detection and electrochemical analysis, and comprises the following steps: weighing, constant volume, clarification of the raw material medicine sample, solidifying target ions, standard calibration and peak interval / scanning parameters into a detection parameter table; according to the detection parameter table, the flow and valve control are controlled to complete liquid preparation, muSPE enrichment, washing, elution and constant volume loading on the chip; blank, no standard addition, one-time standard addition and numbered archiving are sequentially measured; baseline is made according to the solidified parameters, integration and blank deduction are carried out, the solution concentration is calculated combined with standard addition measurement, and the content is output. The method disclosed by the application can constrain micro-fluidic liquid preparation, enrichment, elution and constant volume loading, so that blank, no standard addition and standard addition three rounds are measured under the same source condition; the curve and standard addition measurement are numbered and archived, integral, blank deduction and concentration are solved simultaneously, and the quantitative consistency, traceability and calculation reliability are improved.

The application discloses a kind of composite gel breaking-directional adsorption purification combined special medical thickening component nitrate rapid detection method, belong to food detection technical field.The application is aimed at special medical food thickening component nitrate detection, colloid structure causes target extraction efficiency to be low, gel breaking effect and heat-sensitive component protection are difficult to give consideration to, method adaptability is poor, matrix interference is serious technical problem, first by LDA linear discriminant analysis model realizes sample classification and targeted gel breaking scheme matching, then adopts differentiating composite gel breaking system to cooperate entropy weight method-TOPSIS dynamic end point determination, by colloid polysaccharide characteristic fragment surface imprinting mesoporous nanometer silicon dioxide directional adsorption purification, finally by 15 N mark temperature-sensitive type isotopic internal standard is combined with three-wavelength in-situ calibration to complete quantitative detection.The method has good detection accuracy and repeatability, is suitable for multi-scene detection requirements, and can meet the quality control requirements of trace nitrate detection of special medical food.

The invention belongs to the technical field of biological detection, and particularly relates to a method for analyzing and detecting IgG N-glycan in dried blood spots. The dried blood spot sample is adopted to replace a traditional serum sample, so that the technical problem of IgG N-carbohydrate chain degradation under the normal-temperature storage condition of the serum sample is effectively solved, and the stability of the sample and the reliability of a detection result are remarkably improved. The dried blood spot sample collecting method is simple and convenient, vein blood sampling is not needed, the method is suitable for large-scale screening and application of special crowds, and the clinical application range of IgG N-glycan analysis is widened. Besides, the dried blood spot sample can be stored for a long time at room temperature, the transportation and storage cost is reduced, meanwhile, analysis can be completed only through a trace amount of blood, the method is suitable for repeated sampling and long-term monitoring, and a technical support is provided for research and application of IgG glycosylation as a biomarker.

The utility model discloses a device for detecting the concentration of multi-component trace gas, and particularly relates to the technical field of gas detection equipment, the device comprises a gas chromatograph main body, one side of the outer surface wall of the gas chromatograph main body is connected with a gas inlet pipe, the lower end of the gas inlet pipe is fixedly connected with a fixed seat on the outer surface wall of the gas chromatograph main body, and the fixed seat is fixedly connected with the gas chromatograph main body. A treatment cylinder is connected to the interior of the fixed seat, a partition plate is connected to the interior of the treatment cylinder, and a concentration structure is arranged on one side of the partition plate. By arranging the concentration structure, low-concentration trace gas can be concentrated and enriched, extremely-low-concentration gas which is originally difficult to detect is gathered in quantity, the concentration of the trace gas in a gas sample is greatly improved, and a detection signal becomes easy to capture and analyze from weak, so that the detection sensitivity is greatly enhanced; trace gas components which are possibly omitted in the past can be accurately found, and the reliability and the accuracy of a detection result are improved.

The invention discloses a method for efficiently detecting trace residues of'three-high 'drugs in fish plasma, the'three-high' drugs comprise triamterene, terazosin, rosiglitazone, lovastatin, benazepril, pitavastatin and repaglinide, and the method comprises the following steps: adding an anticoagulant into a collected fish plasma sample, centrifuging, taking supernate, and collecting the supernate; the method comprises the following steps: firstly, adding an internal standard solution, adding acetone containing formic acid with the volume fraction of 1% into a purification tube, loading a labeled sample, pressurizing to ensure that the sample drips in a drop shape, collecting by using a polypropylene test tube containing a purification reagent, oscillating and purifying, centrifuging, taking supernate, and concentrating to obtain a concentrated solution; the method disclosed by the invention is high in sensitivity, and the detection limit range of seven kinds of drugs for target'three highs' in the blood plasma of the aquatic environment fish is 0.02-0.25 ng / mL.

The application discloses a liquid inlet device of a thrombolytic catheter, which comprises a catheter main body, a sealed box and a propelling assembly. The outer side of the catheter main body is sleeved with an outer pipe, the inner side surface of the outer pipe is provided with a flow guide groove, the inner bottom wall of the flow guide groove is provided with a plurality of flow guide holes, the outer pipe end part located on the outer side of a human body is fixedly connected with a flow guide ring which is internally hollow, each flow guide groove is communicated with the inner part of the flow guide ring, the sealed box is placed with a bag body which internally contains an anticoagulant liquid, the sealed box is communicated with the inner part of the flow guide ring through a branch pipe, and the propelling assembly is communicated with the inner part of the sealed box through a connecting pipe. The sealed box is inflated through the propelling assembly, the air pressure is enhanced to extrude the bag body when the gas enters the sealed box, the anticoagulant liquid in the bag body is slowly and continuously flowed into a plurality of flow guide grooves through the branch pipe, and then is flowed out of a blood vessel cavity, so that the formation of a cavity intramural thrombus is reduced, and then the whole blood vessel cavity continuously has a trace amount of anticoagulant drug, which can effectively dissolve the thrombus in the blood vessel cavity and on the outer wall of the thrombolytic catheter.

The invention relates to the technical field of biological medicine detection, and particularly discloses an enrichment detection method for trace drug metabolites in a clinical biological sample. In order to solve the problems that samples are complex, trace substances are difficult to detect and the like, through a nano material-aptamer collaborative enrichment module, a micro-fluidic chip-ultrasonic extraction module, a multi-dimensional chromatography-high-resolution mass spectrometry module and the like, a quantitative algorithm fused by a background noise suppression algorithm based on deep learning and a dynamic programming-genetic algorithm is combined; the efficient enrichment, accurate detection and accurate analysis of the metabolite are realized. Meanwhile, the intelligent quality control module ensures that the result is reliable. According to the method, the detection sensitivity and accuracy are remarkably improved, and powerful support is provided for clinical drug monitoring and disease diagnosis.

The invention relates to a trace hydroxyputrescine lysine protein detection method, which comprises: 1) preparing a sample to be detected, and slicing cells, body fluid or tissue; (2) sealing the sample by using Duolink sealing liquid; (3) diluting an anti-rabbit PLUS probe and an anti-mouse MINUS probe Merck and DUO92101 / DUO92102 in proportion by using a Duolinkantibody diluent, incubating with a product obtained in the previous step, and respectively combining a rabbit polyclonal antibody and a mouse monoclonal antibody through the PLUS / MINUS probe to provide a basis for a ligation reaction; (4) diluting ligase by using a Duolink ligation buffer solution according to the ratio, and incubating with the product in the step (3) at the temperature; 5) diluting an amplification enzyme with a Duolink amplification buffer solution in proportion, and incubating with a product obtained in the previous step; 6, a mounting medium containing DAPI is adopted for mounting, and imaging analysis is carried out through a fluorescence or confocal microscopy. The problem that due to the fact that the affinity of the antibody is insufficient and the protein expression quantity is low, the omission ratio of the trace hydroxyputrescine lysine modified protein is high can be well solved.

The invention belongs to the technical field of atomic absorption spectrometry analysis, and particularly relates to a method for rapidly determining trace Pb in a complex sample under high acidity based on atomic absorption spectrometry, in particular to an analysis method for accurately and rapidly determining trace Pb in cosmetics. According to the method for rapidly determining the trace Pb in the complex sample under the high acidity based on the atomic absorption spectrometry, the HCl concentration of a test system can be greatly improved to 10% by adopting a designed chemical atomizer and optimizing the conditions of reduction reaction; the method breaks through the bottleneck that trace Pb in a few simple samples can only be measured under low acidity by a hydride generation method, so that the chemical reaction of Pb and NaBH4 can be stably carried out under high acidity, the problem of testing trace Pb in complex samples is solved, and the method is high in sensitivity, simple and rapid to operate and reliable in test result.

The utility model discloses a centrifugal machine and a workstation for extracting and enriching trace microorganisms from a complex matrix, the centrifugal machine comprises a main body frame, a partition plate is arranged in the middle of the main body frame, and the centrifugal machine is divided into a centrifugal chamber and an accessory chamber by the partition plate; the rotor assembly is arranged above the partition plate, is positioned in the centrifugal chamber and is used for placing a sample; a refrigeration assembly is arranged on the outer wall of the centrifugal chamber and used for cooling or refrigerating the centrifugal chamber; the positioning assembly is arranged below the partition plate and located in the accessory chamber. When the centrifugal machine is used for separating and enriching infectious samples, most of impurities such as human cells, proteins, saccharides, salts and the like in uncultured or cultured clinical samples such as blood, cerebrospinal fluid, urine, hydrothorax and ascites and the like can be effectively removed, and relatively pure living pathogens are obtained.

The utility model discloses a dose-adjustable pressing sprayer which comprises a screwing cap used for being connected with an external container, a pressure pump body is installed in the screwing cap, a pump pipe is arranged at the top of the pressure pump body, one end of the pump pipe penetrates through the screwing cap and is externally connected with a pressing pump head, and the other end of the pump pipe penetrates through the pressing pump head. The bottom of the pressure pump body is connected with a liquid suction pipe, and the pressure pump is characterized in that the screwing cap is provided with a table top used for installing an elastic telescopic piece. According to the pressing spray head with the adjustable dosage, the quantitative parts with different heights on the trapezoidal quantitative unit are matched with the positioning head on the elastic telescopic piece, so that a user can select different pressing gears by rotating the pressing pump head. And each quantitative part corresponds to a specific pressing stroke, so that the single-time liquid outlet amount is accurately controlled. By means of the design, the dosage requirement from trace use (such as perfume) to large use (such as shower gel) can be met, and waste or complexity of repeated pressing is effectively avoided.

The invention belongs to the technical field of atomic spectrum analysis and detection, and particularly relates to a method for separating trace Se and As in a multi-metal sample and a method for rapidly detecting the trace Se and As in the multi-metal sample based on atomic absorption spectrometry. According to the method for separating trace Se and As in the multi-metal sample, a miniature cation chromatographic column is adopted, especially a zero empty bed volume leaching technology is adopted, the column flow rate can be as high as several milliliters per minute, the elution volume is only 1-2 milliliters, the separation effect is close to 100%, only 2-3 minutes are needed for collecting As or Se flowing through a column bed, the separation speed is high, and the separation efficiency is high. And the determination result is accurate and reliable.

The invention relates to an HPLC (High Performance Liquid Chromatography) detection method for a trace starting material 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide hydrochloride in fluralana, and belongs to the technical field of pharmaceutical analysis. According to the present invention, 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide and benzoyl chloride are subjected to an amidation reaction under an alkaline condition so as to obtain the derivative, and the derivative has strong ultraviolet absorption characteristic, and is detected and analyzed by using a high performance liquid chromatograph; the method has the advantages of short derivatization time, mild reaction conditions, simplicity and convenience in operation, good specificity and accuracy, high sensitivity and the like. The method provided by the invention is suitable for rapid detection of a trace amount of starting material 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide hydrochloride in a finished product of fluralana in industrial production.

The application belongs to the technical field of medicine, and particularly relates to a ketoprofen in-situ co-amorphous composition. The co-amorphous composition is composed of ketoprofen, lysine, arginine and meglumine, and can spontaneously form a homogeneous disordered arrangement when contacting with an aqueous medium (including a dissolution process). Through powder X-ray diffraction, differential scanning calorimetry and Fourier infrared spectroscopy analysis, the three compositions can be co-amorphized in-situ when contacting with a trace amount of aqueous medium or in a dissolution process, so that the solubility and dissolution rate of ketoprofen are significantly improved, and the oral absorption and therapeutic effect of ketoprofen are expected to be enhanced. Meanwhile, the degree of in-situ co-amorphization is closely related to the molar ratio of the composition, the contacting time, the pH and the temperature of the medium. The application mediates the occurrence of in-situ co-amorphization of ketoprofen through prescription composition and design, improves the solubility and dissolution defects of the drug, and provides a new preparation idea.

This invention discloses a sample introduction probe device and method based on a membrane-assisted strategy. The device employs a membrane-assisted strategy to achieve in-situ pretreatment, injection, transfer, separation, and detection of trace amounts of complex samples under pressure. The main advantages of this invention include: integrating trace sample pretreatment with injection, chromatographic separation, and detection systems; a simple system structure; rapid and automated operation; high flexibility; ease of use; and wide applicability, particularly suitable for the analysis of trace samples. The membrane-assisted strategy enables in-situ sample pretreatment followed by injection, providing a new injection mode for the analysis of complex samples and offering a new approach to the integration and miniaturization of chromatographic analysis systems. This invention has broad application prospects in fields such as bioanalysis, organic synthesis, bioengineering, clinical mass spectrometry, single-cell analysis, analysis of trace complex samples, multi-omics analysis, and bioimaging analysis.

The invention discloses a method for detecting an antiviral drug in a water body, which comprises the following steps: step (1), collecting an environmental water sample, filtering, and adjusting the pH value to strong acidity; (2) activating by adopting an HLB (Hydrophile-Lipophile Balance) solid-phase extraction column, loading a sample, capturing a target object by controlling the flow rate, eluting by using methanol, and concentrating by nitrogen blowing to a constant volume; and (3) separating through a UHPLC system containing a formic acid / methanol mobile phase, and quantitatively analyzing the antiviral drug suitable for positive ion mode detection in an MRM mode through triple quadrupole mass spectrometry. According to the method, the quantitation limit is reduced to a ppt level, and the relative standard deviation of a detection result is RSDlt; the repeatability and the reliability are excellent; the operation is simple, the detection flux is high, and the instrument adaptability is wide; the method is suitable for various water bodies, the recovery rate of the method ranges from 80% to 120%, no obvious matrix effect exists, and reliable technical support is provided for monitoring of trace antiviral drugs in environmental water bodies.

To provide improved techniques for diagnosing esophagogastric cancer in relation to biomarkers and novel biological markers for diagnosing cancer.SOLUTION: Analyzing the level of at least one trace compound in a body sample from a test subject and comparing this level to a reference level, wherein the reference level is the level of the at least one trace compound in an individual or an average level for a population of individuals; Wherein the individual or the population of individuals does not suffer from cancer and wherein (i) an increased level of a particular trace compound in a bodily sample from the test subject as compared to the reference and / or (ii) a decreased level of a particular trace compound in a bodily sample from the test subject as compared to the reference indicates that the subject suffers from or is predisposed to cancer or indicates a negative prognosis for the subject's condition.SELECTED DRAWING: Figure 1

The application discloses a kind of micro water long-range transmission-collection method and device;To solve the problem that the existing water transmission collection method is easily attached or adsorbed on the surface of pipeline, resulting in low transmission efficiency of micro water, serious loss, specifically including building micro water long-range transmission-collection device;Block the communication of long-range pipeline and micro water container, the water in long-range pipeline and water collection unit is fully desorbed and then reduced to room temperature;Connect long-range pipeline and micro water container, open the vacuum pump to start vacuumizing, the micro water in micro water container is transmitted to water collection unit, and the micro water is absorbed by water collection unit, when the air pressure in water collection unit is less than the preset pressure, close the vacuum pump, water collection unit continues to absorb micro water, so that the air pressure in water collection unit is continuously less than the air pressure in micro water container, the remaining micro water continues to be transmitted to water collection unit under the action of air pressure and is absorbed by water collection unit, until the long-range transmission and collection of micro water are completed.

The invention discloses a high-sensitivity DPJ-CE-MS method for detecting neurotransmitters and histamine metabolites, a kit and application, and belongs to the technical field of life analysis and detection. According to the method, a dynamic pH linkage on-line enrichment technology is adopted, alkaline ammonia water and a sample are sequentially injected, and effective pre-concentration of various target objects is achieved in a capillary tube. The background electrolyte and sheath fluid taking formic acid-methanol as a system, and key conditions such as separation voltage, electrospray voltage and the like are optimized. The method combines the advantages of high-efficiency separation of capillary electrophoresis and high-sensitivity and high-specificity detection of mass spectrum, and simultaneous analysis of 11 trace substances such as noradrenaline, glutamic acid, gamma-aminobutyric acid, 5-hydroxytryptamine, histamine and metabolites thereof in the cerebrospinal fluid is realized. Methodology verification shows that the method has excellent sensitivity, precision and accuracy, the detection limit is as low as 0.05-5 ng / mL, and a reliable analysis tool is provided for neuroscience basic research and discovery of biomarkers of related diseases.

This invention discloses a copper nanoparticle-based SERS sensor, its preparation method, and its application in trace detection of doxorubicin. The sensor comprises a porous anodic alumina substrate, metal halide-oxide nanosheets vertically grown on its surface, and copper nanoparticles uniformly deposited on the surface and sidewalls of the nanosheets via atomic layer deposition (ALD). The preparation method involves first preparing the porous anodic alumina substrate via anodic oxidation, then self-assembling and growing the metal halide-oxide nanosheets, and finally using copper hexafluoroacetylacetone as a copper precursor and diethylzinc as a reducing agent, employing ALD to precisely control the particle size and distribution of the copper nanoparticles. This sensor is used for trace doxorubicin detection, with a detection limit as low as 0.5 ppm, covering the clinical therapeutic drug monitoring concentration range. It has the advantages of low cost, high sensitivity, and controllable structure. This invention provides a low-cost, high-sensitivity, structurally controllable, and highly consistent SERS sensor for trace doxorubicin detection.

The invention discloses a small-scale TELP-assisted rapid chromatin immunoprecipitation sequencing method. MNase digestion is adopted to replace ultrasonication, so that the problem of epitope masking possibly caused by cross-linking is avoided. Library construction is carried out by using a TELP method, and efficient capture is realized by using an anchor primer tailed by PolyC and labeled by biotin. Only 3 '-phosphoric acid is removed from the rSAP, preparation is made for a subsequent tailing reaction, thermal inactivation can be achieved, the purification step is omitted, a traditional terminal repair enzyme system is not needed, and TELP has high sensitivity to low-initial-quantity DNA and is suitable for trace DNA produced by ChIP-seq. And through streptavidin magnetic bead capture, all subsequent steps (washing and connecting) are performed on the magnetic beads, so that the sample transfer loss is greatly reduced. 3 '-OH is directly used for tailing, and the steps of tail end repairing and A tail adding which are most likely to cause loss in traditional library building are omitted. According to the method, histone modification can be detected only by using hundreds of cells.

This utility model discloses a valve with anti-leakage function, relating to the field of valve technology. It includes an anti-leakage valve body, an anti-detachment valve core base within the valve body, a first valve core threaded onto the top of the anti-detachment valve core base, and an anti-leakage polygonal valve stem fixedly mounted on the top of the first valve core. The valve body utilizes blue (open) and red (closed) markings on the anti-leakage polygonal valve stem, combined with the number of turns, to clearly indicate the on / off status and degree of opening (each turn corresponds to 1 / 3 of the flow rate). Users can quickly identify and accurately adjust the valve, avoiding misoperation. The anti-leakage valve body employs a T-shaped flow-guiding structure, which guides any possible trace amounts of seepage to the outside for discharge, preventing water from seeping into tiles or walls, protecting the integrity of the decoration, and extending the service life of walls and tiles. The serrated structure of the anti-detachment valve core base provides bidirectional limiting; clockwise adjustment is smooth and effortless, while counterclockwise operation is less prone to loosening and detachment due to the reverse resistance of the serrations, improving the stability and service life of the valve core connection.

The invention relates to application of SERS (Surface Enhanced Raman Scattering) sensing test paper in preparation of a device for noninvasive detection of trace histamine in human tears, and belongs to the field of biosensing and spectral analysis. At least one of the problems that the existing tear detection scheme is insufficient in detection sensitivity, poor in anti-interference capability and low in selectivity and cannot meet the clinical requirements of rapid and on-site instant detection of trace tear samples in practical application is solved. The invention discloses application of SERS sensing test paper in preparation of a device for noninvasive detection of trace histamine in human tears. The SERS sensing test paper comprises a porous fiber matrix and an SERS active nanocomposite loaded on the porous fiber matrix, a human tear sample is applied to the SERS sensing test paper, and a Raman spectrometer is used for collecting SERS signals. According to the invention, the detection sensitivity, anti-pollution capability and selectivity of trace histamine in tears are improved, and non-invasive rapid detection is realized.

The present application relates to a kind of gate device and method for rapidly detecting trace explosive, gate device includes gate shell and explosive detection mechanism, detection sampler, enhanced sampler, detection belt, identity verification mechanism and detection belt transmission mechanism assembled on gate shell;Ticket sampling port is opened on gate shell, detection sampler is located below ticket sampling port and between ticket sampling port and reserved gap for detection belt to pass;Detection belt passes through enhanced sampler, gap, explosive detection mechanism in turn and is driven to run by detection belt transmission mechanism;Wherein, enhanced sampler includes the electrostatic mechanism of increasing electrostatic to detection belt or the solvent mechanism of forming solvent film in detection belt.The measured personnel will put ticket into equipment and produce contact, using enhanced sampler to improve the collection and adsorption capacity of detection belt to explosive, combined with trace explosive detection mechanism, the screening of person, certificate and explosive can be realized by once through gate, improve explosive screening efficiency and coverage.

The present invention aims to develop a technique for measuring neutrophil counts using small amounts of blood, such as 1 μL or less, as obtained by fingertip puncture. [Solution] A method for measuring the number of neutrophils in a blood sample is provided, which includes measuring superoxide anions in the presence of bortezomib or ixazomib or a salt thereof.