13 results about "Trace Amounts" patented technology

This invention discloses a rapid mass spectrometry method and kit for the simultaneous detection of multiple components in body fluids, belonging to the field of biological detection and identification technology. It can rapidly detect trace compounds such as drugs and biomarkers in complex biological samples. This kit mainly utilizes loaded functional materials to achieve extraction and enrichment of target analytes and is equipped with a quick connector for coupling with a detector to achieve rapid detection. Compared with traditional methods, the significant advantages of the method established by this kit are that it does not require complex sample pretreatment, allows for micro-quantitative sampling, requires small sample volumes, facilitates convenient storage of biological samples, is easy to operate, does not require specialized technical personnel, and enables rapid on-site detection when coupled with portable mass spectrometry. This kit has been successfully used for the detection of quinine, procainamide hydrochloride, atenolol, and nortriptyline in complex samples such as blood and serum, and has significant clinical and economic value.

The application discloses a raw material medicine trace heavy metal ion detection method and system based on a micro-fluidic chip, relates to the technical field of micro-fluidic detection and electrochemical analysis, and comprises the following steps: weighing, constant volume, clarification of the raw material medicine sample, solidifying target ions, standard calibration and peak interval / scanning parameters into a detection parameter table; according to the detection parameter table, the flow and valve control are controlled to complete liquid preparation, muSPE enrichment, washing, elution and constant volume loading on the chip; blank, no standard addition, one-time standard addition and numbered archiving are sequentially measured; baseline is made according to the solidified parameters, integration and blank deduction are carried out, the solution concentration is calculated combined with standard addition measurement, and the content is output. The method disclosed by the application can constrain micro-fluidic liquid preparation, enrichment, elution and constant volume loading, so that blank, no standard addition and standard addition three rounds are measured under the same source condition; the curve and standard addition measurement are numbered and archived, integral, blank deduction and concentration are solved simultaneously, and the quantitative consistency, traceability and calculation reliability are improved.

This invention discloses a copper nanoparticle-based SERS sensor, its preparation method, and its application in trace detection of doxorubicin. The sensor comprises a porous anodic alumina substrate, metal halide-oxide nanosheets vertically grown on its surface, and copper nanoparticles uniformly deposited on the surface and sidewalls of the nanosheets via atomic layer deposition (ALD). The preparation method involves first preparing the porous anodic alumina substrate via anodic oxidation, then self-assembling and growing the metal halide-oxide nanosheets, and finally using copper hexafluoroacetylacetone as a copper precursor and diethylzinc as a reducing agent, employing ALD to precisely control the particle size and distribution of the copper nanoparticles. This sensor is used for trace doxorubicin detection, with a detection limit as low as 0.5 ppm, covering the clinical therapeutic drug monitoring concentration range. It has the advantages of low cost, high sensitivity, and controllable structure. This invention provides a low-cost, high-sensitivity, structurally controllable, and highly consistent SERS sensor for trace doxorubicin detection.

This utility model discloses a valve with anti-leakage function, relating to the field of valve technology. It includes an anti-leakage valve body, an anti-detachment valve core base within the valve body, a first valve core threaded onto the top of the anti-detachment valve core base, and an anti-leakage polygonal valve stem fixedly mounted on the top of the first valve core. The valve body utilizes blue (open) and red (closed) markings on the anti-leakage polygonal valve stem, combined with the number of turns, to clearly indicate the on / off status and degree of opening (each turn corresponds to 1 / 3 of the flow rate). Users can quickly identify and accurately adjust the valve, avoiding misoperation. The anti-leakage valve body employs a T-shaped flow-guiding structure, which guides any possible trace amounts of seepage to the outside for discharge, preventing water from seeping into tiles or walls, protecting the integrity of the decoration, and extending the service life of walls and tiles. The serrated structure of the anti-detachment valve core base provides bidirectional limiting; clockwise adjustment is smooth and effortless, while counterclockwise operation is less prone to loosening and detachment due to the reverse resistance of the serrations, improving the stability and service life of the valve core connection.

The present invention aims to develop a technique for measuring neutrophil counts using small amounts of blood, such as 1 μL or less, as obtained by fingertip puncture. [Solution] A method for measuring the number of neutrophils in a blood sample is provided, which includes measuring superoxide anions in the presence of bortezomib or ixazomib or a salt thereof.

This invention relates to the field of blood collection and testing technology, specifically to a sampling device for sepsis detection. The device includes a main blood collection tube and a shunt box. The shunt box contains a flow path assembly, which includes a first branch tube, a second branch tube, and a third branch tube, each connected to the main blood collection tube. The third branch tube is connected to a clinical testing component. The shunt box also contains a pumping assembly, which includes a drive assembly and several rotating rollers, all rotatably connected to the drive assembly. The shunt box also contains a first base and a second base. The second base contains clamping assemblies corresponding to the first, second, and third branch tubes, and each clamping assembly contains a sensing component. This invention is used to automatically, accurately, and sequentially complete the entire process of collecting multiple blood culture samples and rapidly detecting trace amounts of blood after a single venipuncture, solving the technical problems of high contamination risk, inaccurate blood volume, cumbersome procedures, and disconnect from rapid diagnosis inherent in traditional manual operations.

This invention relates to a sports fatigue monitoring and management system and a sports fatigue monitoring and management method. Firstly, it provides a sports fatigue monitoring and management system, including an electronic fabric patch, a multimodal sensing module, and a data transmission and interaction module. The electronic fabric patch can be attached to the skin surface of a subject, and its electrode structure forms a multimodal sensing module capable of detecting flowing sweat or directly monitoring the subject's body. The electronic fabric patch uses porous fabric and gradient micropillar structures to dynamically regulate the accumulation of trace amounts of sweat and the drainage of excessive sweat, simultaneously collecting multidimensional physiological and biochemical indicators such as electromyographic signals, electrolytes, metabolites, and hormones. Additionally, an AI assessment module is deployed, based on a multi-algorithm fusion model trained using observation data during the rest-exercise-recovery process, to identify six types of fatigue-related states and generate intervention plans. In some embodiments, this can reduce fatigue levels by 51.82%, accelerate chronic fatigue recovery, and is suitable for athlete training monitoring and rehabilitation patient exercise management.

The utility model discloses a system for qualitative detection trace silicon in unknown object, including generator, sodium hydroxide feed arrangement, gas detection device and emptying device, and the generator includes generator body and sets the thing tray in the generator body, is equipped with the opening on the generator body upper end, is equipped with the sealing plug in the opening, is equipped with the through -hole I, through -hole II and through -hole III for device installation on the sealing plug, the thing tray is the thing tray of mesh adjustable, and sodium hydroxide feed arrangement includes feeding hopper and feed pipe, and gas detection device includes detection tube and the piston of setting in detection tube, is equipped with the scale on detection tube, and emptying device includes emptying air pipe, pipette and liquid tank, is equipped with the check valve on emptying air pipe, and pipette end extends to below liquid level in liquid tank, is equipped with the scale on pipette. The system can realize qualitative detection trace silicon in unknown object fast, efficiently, and the error is less, to provide reference basis for silicon analysis in unknown sample.

The present application relates to the technical field of robots, and in particular to a piezoelectric robot for precise injection of trace drugs and a method for searching for a parafocal position; the piezoelectric robot for precise injection of trace drugs comprises: a base, a planar three-degree-of-freedom piezoelectric platform is arranged on the base, an injection object is arranged on the planar three-degree-of-freedom piezoelectric platform, and the planar three-degree-of-freedom piezoelectric platform is used to drive the injection object to translate and rotate; a piezoelectric automatic focusing system is arranged on the base, and the piezoelectric automatic focusing system is arranged correspondingly with the planar three-degree-of-freedom piezoelectric platform, and the piezoelectric automatic focusing system is used to focus and monitor the injection object in situ; a piezoelectric injection system comprises a piezoelectric injector, a fixing support and a three-degree-of-freedom motion platform; the piezoelectric robot for precise injection of trace drugs has the characteristics of compact structure, fast focusing speed, precise control of trace drugs and high automation degree.

This invention provides a method for detecting trace amounts of N-methylmorpholine residues in gels using gas chromatography-mass spectrometry (GC-MS). This method is highly specific, sensitive, linear, precise, accurate, has high solution stability, is durable, and provides accurate and reliable measurement results. It offers strong support for effectively controlling the quality, efficacy, and safety of related medical aesthetic products and ensuring their quality control.

LB tests have the following four primary problems: a trace amount of cfDNA that is an LB test subject should be highly efficiently recovered; gDNA that is an LB test inhibition factor should be eliminated; the time of complicated centrifugal separation operations should be reduced to one time; and plasma that contains a trace amount of cfDNA should be recovered without loss. The purpose of the present invention is to solve at least one of the above-mentioned primary problems in LB tests. A biological sample preparation reagent according to the present invention comprises: at least one type of salting-out effect molecule of which the final concentration is 4 wt% or more when mixed with a sample; and at least one type of excluded volume effect molecule of which the final concentration is 5-8 wt% when mixed with a sample (see Fig. 1).

This invention belongs to the field of medical patch technology. It discloses a reusable patch comprising, from bottom to top, a non-woven fabric layer, a PU film adhesive layer, a core, a leak-proof pad, a cover cotton, and a release film. The outer surface of the PU film is coated with a composite adhesive layer for durable adhesion. The core, made of a special matrix, traditional Chinese medicine powder, oil, and excipients, is adhered to the center of the PU film through this composite adhesive layer. A leak-proof pad, preferably with an annular leak-proof ring, is provided between the core and the PU film to effectively prevent side leakage of the core components. The cover cotton covers the core to absorb trace amounts of exudate. This invention, through the synergistic design of the silicone gel composite adhesive layer and the leak-proof structure, ensures good sustained-release of the medication and comfortable application while enabling the patch to be repeatedly peeled and reapplied. This solves the problems of traditional single-use patches being prone to leakage and contamination, making it economical, practical, and providing a superior user experience.

This invention discloses a method for desalting and purifying high-salt small RNA based on surface-spiked silica nanoparticles and its application, belonging to the fields of biotechnology and molecular biology. The method involves diluting a small RNA sample containing a high concentration of salt ions to adjust the salt ion concentration, adding surface-spiked silica nanoparticles (VSN) to adsorb the RNA, centrifuging to separate the nanoparticles and washing to remove salt ions, adding a release solution to release the adsorbed small RNA, and collecting the liquid containing the small RNA. This invention optimizes the salt concentration after dilution, the amount of nanoparticles and incubation conditions, the number of VSN washes, and the alkaline release conditions, making it suitable for the rapid desalting and recovery of small RNA in high-salt systems. It effectively overcomes the shielding effect of high-salt environments on electrostatic adsorption, achieving efficient recovery of small RNA while significantly reducing salt concentration. Furthermore, it eliminates the need for toxic organic solvents, is simple and rapid to operate, and is suitable for the extraction and detection of trace amounts of small RNA.