The invention discloses a traditional Chinese medicine preparation special for local anesthesia. The traditional Chinese medicine preparation is prepared from the following main raw materials by weight: 3-5 parts of Datura metel, 1-3 parts of Radix Aconiti Kusnezoffii, 1-5 parts of dragon's bone, 2-4 parts of licorice, 5-10 parts of mint, 6-18 parts of Chinese prickly ash, 5-15 parts of myrrh, 10-20 parts of as arum, 6-12 parts of saffron, 3-8 parts of radix angelicae pubescentis, 1-3 parts of scorpion, 1-3 parts of centipede, 2-5 parts of fructus liquidambaris, 3-7 parts of safflower, 5-9 parts of rhodiola root, 5-10 parts of tribulus terrestris, 3-7 parts of Chinese honeylocust spine, and 2-6 parts of Arenaria taibaishanensis, etc. The traditional Chinese medicine preparation special for local anesthesia provided by the invention "pays attention to the whole", can be used for local anesthesia, and also can be used for local pain after local anesthesia, thus being a major characteristic different from drug prevention. Also, the traditional Chinese medicine preparation special for local anesthesia is prepared completely according to the principles of traditional Chinese medicine, is safer and more reliable, and has no toxic or side effect.