The invention relates to the fields of
organic synthesis and
medicinal chemistry, and particularly relates to an O-(tetrahydropyrrole) ethyl derivative of cleistanthus sumatranus
ketone Cleistanone, a preparation method and an application of the O-(tetrahydropyrrole) ethyl derivative in preparation of a
medicine for preventing or treating
renal fibrosis. The invention synthesizes a novel O-(tetrahydropyrrole) ethyl derivative of the cleistanthus sumatranus
ketone Cleistanone, and discloses a preparation method of the O-(tetrahydropyrrole) ethyl derivative. A
pharmacology experiment shows that the O-(tetrahydropyrrole) ethyl derivative of the cleistanthus sumatranus
ketone Cleistanone has the effect of preventing or treating the
renal fibrosis, and has the value of developing the
medicine for preventing or treating the
renal fibrosis.