Application of O-(tetrahydropyrrolyl)ethyl derivative of cleistanone to preparation of medicines for preventing and treating liver injuries

A technology of tetrahydropyrrolyl and ethyl derivatives, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of high toxicity, aggravation, and elevation of liver damage, and achieve good resistance to liver damage Effect
CN104083384AActive Publication Date: 2014-10-08NANJING UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV
Publication Date
2014-10-08

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Abstract

The invention relates to the fields of organic synthesis and medicinal chemistry and in particular relates to an O-(tetrahydropyrrolyl)ethyl derivative of cleistanone, a preparation method and an application of the O-(tetrahydropyrrolyl)ethyl derivative to preparation of medicines for preventing and treating liver injuries. The invention synthesizes the new O-(tetrahydropyrrolyl)ethyl derivative of cleistanone and discloses the preparation method of the O-(tetrahydropyrrolyl)ethyl derivative. Pharmacology experiments show that the O-(tetrahydropyrrolyl)ethyl derivative of cleistanone has the functions of preventing and treating liver injuries and has the value of developing the medicines for preventing and treating liver injuries.
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Description

technical field

[0001] The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to O-(tetrahydropyrrolyl)ethyl derivatives of cleistanone, a preparation method and uses thereof. Background technique

[0002] There are multiple reasons for causing liver damage: 1. Viral infection: caused by a variety of hepatitis viruses, with strong infectivity, complex transmission routes, wide epidemic range, and high incidence rate. 2. Drugs or chemical poisons: Many drugs and chemical poisons can cause liver damage, drug-induced hepatitis or toxic hepatitis. 3. Alcoholism: Alcohol damages the liver very seriously. The consequences of the damage include alcoholic hepatitis, alcoholic fatty liver, and alcoholic cirrhosis, mainly due to the toxicity of alcohol (ethanol) and its metabolite acetaldehyde on liver cells. caused by direct damage. 4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certai...

Claims

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