67 results about "Alcoholic hepatitis" patented technology

The present embodiments relate to methods for the prevention and treatment of inflammatory conditions such as alcoholic liver disease (ALD). More specifically the present embodiments relate to the prevention and treatment of ALD through the administration of an Retinoic Acid Receptor (RAR) agonist. Some embodiments relate to use of tazarotene in the prevention and treatment of alcohol-induced liver injury, alcohol-related liver disease, fatty liver disease, hepatic steatosis, alcoholic hepatitis or alcoholic cirrhosis.

The invention relates to a Chinese herbal preparation for treating alcoholic fatty liver and the preparation method. The Chinese herbal preparation contains Astragalus root, Barbary Wolfberry Fruit, Largehead Atractylodes Rhizome, Pericarpium Citri Reticulatae Viride, Lobed Kudzuvine Root, Chicken's Gizzard-membrane (prepared), rose and Radix Rhapontici seu Radix Echinopsis. When the Chinese herbal preparation is prepared, the methods such as vapor distilment, water decoction and ethanol extraction are adopted for different ingredients for reaching the purpose of fully developing the efficacy of the drugs. The invention has the effects of replenishing qi and liver, detoxifying and descending turbid, eliminating blood stasis and freeing channels and applied for treating alcoholic fatty liver, alcoholic hepatitis and alcoholic hepatocirrhosis (liver energy deficiency, alcoholic impairment of liver, haemostasis and turbid lipid blocked in liver collaterals); the symptoms are embodied in flank ribs expansion and smothering, secret anguish, accidie and hypodynamia, intolerant fatigue, lassitude, easy fear and restiness, anorexia, tongue coating darkness, white fur and small and wiry pulse. The invention is a safe and reliable good medicine which has the advantages of prescription basing on the Chinese medical theory, sufficient drug source, simple process and evident effect.

The invention relates to the application of Ilex latifolia total glycosides and a preparation method thereof. Studies finds that the Ilex latifolia total glycosides can reduce the content of malonaldehyde (MDA) and triglyceride (TG) in liver, increase the content of reduced glutathione (GSH) in each dose group of liver, reduce the content of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in liver, and has alcoholic hepatitis and fatty liver resisting activity. Compared with the prior art, the invention provides a new application of Ilex latifolia total glycosides in preparing drugs and/or functional food for preventing and/or treating alcoholic hepatitis and fatty liver; the invention also provides a preparation method of the Ilex latifolia total glycosides with the advantages of safe and simple process, saved cost, high efficiency, and easy quality control; and the invention further provides a preparation of the Ilex latifolia total glycosides.

The present invention provides one kind of Isodon lophanthoides extract. The Isodon lophanthoides extract is prepared through crushing Isodon lophanthoides to powder finer than 10 mesh, adding water of over 3 times, extracting at 10-60 MPa pressure and concentrating. The extract may be used in preparing various clinically acceptable orally taken preparations for treating hepatitis B, immunologic hepatitis, alcoholic hepatitis and hepatic fibrosis. The extracting process with ultrafine grinding and high pressure extracting has high extracting rate of the effective components in Isodon lophanthoides, so that the extract has high treating effect.

The invention relates to the field of drug research and development and particularly discloses an application of a compound HUBIN-1 in preparation of a drug for preventing and/or treating liver inflammatory diseases. Extensive and deep research discovers the hepatocyte protection function and the anti-inflammatory treatment function of the compound HUBIN-1 for the first time, the compound HUBIN-1 is applicable to various types of liver inflammations, and the application field of the compound HUBIN-1 is broadened. The novel drug for preventing and/or treating various liver inflammatory diseases such as acute hepatitis, chronic hepatitis and severe hepatitis (hepatic failure) which include viral hepatitis, drug-induced hepatitis, nonalcoholic fatty liver disease, alcoholic hepatitis, autoimmune hepatitis and the like is provided and has remarkable social benefits.

The invention includes a method of preventing or treating a toxic liver disease or disorder, such as but not limited to non-alcoholic steatohepatitis (NASH), liver injury associated with or caused by alcohol consumption in a mammal afflicted with NASH, alcoholic hepatitis, drug induced liver injury, primary sclerosing cholangitis, viral hepatitis, liver fibrosis, liver cirrhosis, and other toxic liver conditions, in a subject, such as a mammal. The invention also includes a method of promoting weight loss in a subject, such as a mammal. The invention comprises administering to the subject a therapeutically effective dose of at least one cardiac glycoside or a solvate, salt, prodrug or derivative thereof.

Provided is a pharmaceutical composition for the treatment and prevention of alcoholic liver diseases, including cilostazol as an active ingredient. Cilostazol inhibits expression levels of TNF-α and FAS (fatty acid synthase) gene in a concentration-dependent manner, and also significantly inhibits the activity of caspase-3. Accordingly, cilostazol shows superior effects for the treatment or prevention of alcoholic liver diseases, in particular, alcoholic hepatitis compared to pentoxifylline which is conventionally used as a therapeutic agent for the treatment for alcoholic hepatitis. Thus, cilostazol is suitable for use as a drug for the treatment or prevention of alcoholic hepatitis.

The invention provides an application of a traditional Chinese medicine composition in preparation of a medicine for treating alcoholic hepatitis. The traditional Chinese medicine composition is prepared by traditional Chinese medicines such as Tibetan caragana, phyllanthus emblica, lagotis brevituba, sandalwood padauk, swertia chirata, medicine terminalia fruit, seabuckthorn paste and rhubarb. Clinical experiments show that the traditional Chinese medicine composition has significant clinical curative effects on the alcoholic hepatitis.

A Chinese medicine for treating alcoholic hepatitis is prepared from 12 Chinese-medicinal materials including red sage root, rhubarb, fleece flower root, astragalus root, etc. Its preparing process is also disclosed.

The invention provides a liver-protecting and alcohol-removing Chinese herbal medicine preparation for treating alcoholic hepatitis caused by alcoholic poisoning. The Chinese herbal medicine preparation is prepared from the following raw materials in parts by weight: 11-15 parts of pueraria flowers, 5-7 parts of fructus amomi, 5-7 parts of amomum cardamomum, 10-14 parts of rhizoma alismatis, 8-12 parts of white atractylodes rhizome, 13-17 parts of poria cocos and 11-15 parts of grifola. The Chinese herbal medicine preparation is a pure Chinese herbal medicine preparation; the pueraria flowers are adopted for removing alcohol, quenching thirst and removing alcohol poison; the fructus amomi and the amomum cardamomum are adopted for promoting vital energy to relieve pain, warming stomach to stop diarrhea and resolving dampness to remove lumps; the rhizoma alismatis, the white atractylodes rhizome, the poria cocos and the grifola are adopted for clearing damp, promoting diuresis, tonifying spleen, benefiting vital energy, strengthening exterior, reducing sweat and calming nerves; all the raw materials are combined for protecting liver, removing alcohol and treating the alcoholic hepatitis.

The invention relates to a medicine used for treating decompensated liver cirrhosis, and a preparation method thereof. Currently, decompensated liver cirrhosis is treated by liver protection, human plasma albumin and diuretic intravenous supplement, repeated ascites paracentesis, and the like. The treatment course is long, and treatment effect is poor. The medicine provided by the invention comprises: Mongolian milkvetch root, largehead atractylodes rhizome, swordlike atractylodes rhizome, agaric, florist's chrysanthemum, Asiatic plantain seed, common yam rhizome, ginseng, stir-fried malt, stir-fried medicated leaven, salvia miltiorrhiza, radix saussureae, hawthorn fruit, dandelion, mix-fried scale, mix-fried turtle shell, peach seed, rhubarb, composite protein powder, lecithin vitamin E, and colostrum capsules. The medicine provided by the invention is used for treating decompensated liver cirrhosis diseases. The medicine has the functions of hard mass softening, stasis removing, spleen invigorating, and dampness removing. Through liver protection, dieresis, and nutritional immunology effect improving, ascite is discharged. The medicine has a good treatment effect against decompensated liver cirrhosis after alcoholic hepatitis or viral hepatitis.

The present invention discloses an alcoholic hepatitis treatment Kazakh traditional drug composition and a preparation method thereof, wherein a six-element theory of the traditional medicine theory basis "Kazakh Medicine Outline" is combined, the six-element theory comprises a "a le te tu gu er theory", a "hu wa ti" theory (ie., a qi, function and energy theory), a "su le" theory (ie., a body fluid theory), a "mu xie lie er" theory (ie., an organ theory), and the like, and the composition has effects of prevention and treatment of various common colds such as viral cold, wind cold type cold and the like. The preparation method comprises: selecting the traditional and commonly used medicinal plant Rhamnus Cathartica L fruit (ie., Xinjiang drug buckthorn fruit), raw milkvetch root and radix puerariae, carrying out water extraction and ethanol extraction, and uniformly mixing to prepare an oral preparation, wherein formulations comprise an decoction, pills, powders, granules, tablets and other oral formulations suitable for clinical alcoholic hepatitis prevention and treatment. The alcoholic hepatitis treatment Kazakh traditional drug composition particularly provides a good treatment effect for alcoholic hepatitis oral adjuvant therapy, and has characteristics of reasonable formula, convenient preparation, exact treatment effect, rapid effect, no stimulation, and no other toxic-side effects.

The present invention belongs to the field of medicine technology, and is especially a kind of medicine composition and its preparation process. The medicine composition is prepared with kurarinone 4-400 weight portions, glutathione 3-300 weight portions, and tiopronin 1-100 weight portions. The medicine composition may be prepared into different pharmaceutically acceptable forms, preferably injection and oral preparation. It has the pharmacological activities of antagonizing virus, improving liver cell function, antagonizing liver fibrosis, regulating immunity, diminishing inflammation, etc. and may be used in treating various hepatic diseases, viral hepatosis, medicinal hepatosis, alcoholic hepatosis, etc.

The invention relates to application of ozonized oil in liver disease prevention and treatment and a drug combining with a liver disease treatment drug. Hepatitis B, hepatitis C, hepatitis D, hepatitis E, alcoholic hepatitis, drug-induced hepatitis, autoimmune hepatitis, liver fibrosis, liver cirrhosis and fatty liver are effectively prevented and treated.

The invention provides a traditional Chinese medicine composition for the treatment of chronic liver disease. The composition is made from the following raw materials by weight: 1 part of swertia mileensis, 0.4-0.7 part of capillary Artemisia, 0.4-0.7 part of Astragalus mongholicus, 0.3-0.6 part of herba verbenae, 0.2-0.5 part of herba taching, 0.1-0.2 part of radix bupleuri, 2-8 parts of bighead atractylodes rhizome, 10-15 parts of red ginseng, 10-13 parts of corydalis tuber, and 15-25 parts of Stephania tetrandra. The invention also provides a preparation method of the traditional Chinese medicine composition for the treatment of chronic liver disease. Compared with the prior art, the invention has the following advantages of supporting right, dispelling evil, clearing heat and draining dampness, clearing liver and gallbladder damp-heat, and purging damp fire of liver and gallbladder. The composition is used for the treatment of acute jaundice hepatitis, chronic icteric hepatitis, chronic hepatitis, liver cirrhosis, liver ascites, alcoholic hepatitis, fatty liver, hepatitis B and transaminase elevation, also can be used for the control of liver cancer.