17 results about "Alcoholic hepatitis" patented technology

25HC3S choline and crystalline 25HC3S choline are described herein. Pharmaceutical formulations of 25HC3S choline such as with crystalline 25HC3S choline and methods of treating or preventing disease with same such as hypercholesterolemia, hypertriglyceridemia, and conditions related to fat accumulation and inflammation (e.g., non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, acute kidney injury (AKI), psoriasis, and atherosclerosis) are further disclosed herein. Methods for preparing 25HC3S, including crystalline 25HC3S choline, are also provided.

The present application provides a variety of salts of 25HC3S, including crystalline salts of 25HC3S. Provided herein are pharmaceutical formulations of the salts of the invention, and methods of treating or preventing diseases therewith, the diseases such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, acute kidney injury (AKI), psoriasis, atherosclerosis, hypercholesterolemia, hypertriglyceridemia, alcoholic fatty liver disease (AFLD), alcoholic steatohepatitis (ASH), leptin resistance, leptin deficiency, diabetic conditions, autoimmune conditions, inflammatory conditions, and the like. Nervous system disorders, EB virus related growth, and disorders associated with fat accumulation and inflammation. Methods of making the salts of the present application are also provided.

25HC3S choline and crystalline 25HC3S choline are described in the present application. Further disclosed herein are pharmaceutical formulations of 25HC3S choline (e.g., containing crystalline 25HC3S choline) and methods of using the pharmaceutical formulations to treat or prevent diseases such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, acute kidney injury (AKI), psoriasis, atherosclerosis, hypercholesteremia, hypertriglyceridemia, and the like. Methods of treating fatty liver disease (AFLD), alcoholic steatohepatitis (ASH), leptin resistance, leptin deficiency, diabetic conditions, autoimmune conditions, inflammatory conditions, neurological conditions, Epstein-Barr virus associated growth, and conditions associated with fat accumulation and inflammation are provided. Also provided herein are methods of making 25HC3S, including crystalline 25HC3S choline.

The liver-protecting health-care tea comprises 20 parts of Pu'er tea, 10 parts of centella asiatica leaves, 10 parts of nutgall, 20 parts of dried longan, 10 parts of chrysanthemum, 10 parts of penthorum chinense pursh, 10 parts of dendrobe and 10 parts of Chinese dates. The tea is prepared into tea bags, and each bag is 30g. The traditional Chinese medicine composition is simple in process and low in cost, has a remarkable treatment effect on acute and chronic hepatitis, cholestatic hepatitis, alcoholic hepatitis, fatty liver and the like, and also has the effects of clearing fat, losing weight, inducing diuresis, promoting alcohol metabolism, protecting liver after drinking and the like; the liver health tea bag provided by the invention is rich in nutritional ingredients, very convenient to drink for a long time, high in appearance grade, convenient to use, strong, mellow, sweet and fragrant in taste and worthy of being well developed and utilized, and the products are placed in the tea bag in proportion.

The invention discloses a composition for preventing and treating non-alcoholic steatohepatitis and preparation and application thereof.The preparation method includes the steps that olive leaves and boxthorn leaves serve as raw materials and are extracted, concentrated and filtered, and then an olive leaf extract with the oleuropein content larger than 50% and a boxthorn leaf extract with the total flavone content larger than 60% are obtained through macroporous resin separation and purification; and mixing different olive leaf extracts and boxthorn leaf extracts according to a certain ratio to obtain the composition for preventing and treating the non-alcoholic steatohepatitis, wherein the composition has a remarkable synergistic effect in prevention of the non-alcoholic steatohepatitis.

This document describes the crystalline and liquid crystalline forms of sodium 25HC3S. This disclosure includes sodium 25HC3S in forms I, II, III, V, IX, XI, and XIII, and combinations thereof. Pharmaceutical formulations of the said forms or combinations thereof are further disclosed herein, as well as methods for treating or preventing diseases such as hypercholesterolemia, hypertriglyceridemia, and conditions associated with fat accumulation and inflammation (e.g., non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, acute kidney injury (AKI), psoriasis, and atherosclerosis). Methods for preparing 25HC3S are also provided.

The invention discloses a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating alcoholic hepatitis. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: 15 to 20 parts of radix puerariae, 15 to 20 parts of rhizoma phragmitis, 15 to 20 parts of rhizoma imperatae, 10 to 15 parts of dried herba dendrobii, 6 to 10 parts of fructus citri sarcodactylis, 10 to 15 parts of herba pogostemonis, 15 to 20 parts of herba lophatheri, 6 to 10 parts of herb tea and 10 to 15 parts of pericarpium citri reticulatae. The research finds that the aqueous extract of the traditional Chinese medicine composition can remarkably improve alcoholic liver injury tissue edema and inflammatory cell infiltration, improve the alcohol metabolism capability of a body, relieve inflammatory response and reduce the oxidative stress level of liver tissue, so that the purposes of treating alcoholic hepatitis and protecting the liver are achieved.

To provide a bifunctional degrading agent for interleukin-1 receptor-related kinases and its therapeutic use. [Solution] This disclosure provides a bifunctional compound as an IRAK4 degradation agent via the ubiquitin-proteasome pathway, and a method for treating diseases modulated by IRAK4. The compounds of this disclosure or their pharmaceutical compositions are useful as therapeutic agents for treating inflammatory disorders such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), Crohn's disease, ulcerative colitis, necrotizing enterocolitis, gout, Lyme disease, arthritis, psoriasis, pelvic inflammatory disease, systemic lupus erythematosus (SLE), Sjögren's syndrome, inflammation associated with gastrointestinal infections including C. difficile, viral myocarditis, acute and chronic tissue injury, non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, and renal diseases including chronic kidney disease and diabetic kidney disease.

The dominant hepatic encephalopathy is a serious complication of liver cirrhosis and affects lipid and lipoprotein metabolism. The invention relates to a biomarker for prognosis of hepatic encephalopathy. The biomarkers comprise high-density lipoprotein cholesterol, an end-stage liver disease model score, age, gender, upper gastrointestinal hemorrhage, spontaneous bacterial peritonitis, dominant hepatic encephalopathy grading, ascites, aspartic transaminase, glutamic-pyruvic transaminase, total bilirubin, serum albumin, total cholesterol, low-density lipoprotein cholesterol and serum creatinine. The specific value of neutrophil to lymphocyte, the prothrombin time and the prothrombin activity level are one or more. Compared with patients with alcoholic hepatitis, liver diseases, hepatic failure and the like in the prior art, the marker provided by the invention can remarkably improve the evaluation accuracy of the prognosis of the dominant hepatic encephalopathy due to the specificity of people.

The present disclosure relates to methods of predicting liver disease mortality using lipoprotein LP-Z. Described herein are methods for determining patient mortality of alcoholic hepatitis in a biological sample by NMR spectroscopy, and more particularly, methods for determining a Z index score based on the lipoprotein fraction LP-Z in plasma and serum.

Provided herein are therapeutic agents and compositions for treating infections associated with alcohol-associated hepatitis. Also provided herein are methods of expanding the host range of an Enterococcus faecalis, E. faecalis bacteriophage for the treatment of an alcohol-associated hepatitis associated infection.

This disclosure relates, in general, to a process for preparing compounds that are inhibitors of the kinase IRAK4, and to synthetic intermediates prepared thereby. IRAK4 inhibitors may be useful in the treatment of inflammatory and fibrous disorders, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), gout, Lyme disease, arthritis, psoriasis, pelvic inflammatory disease, systemic lupus erythematosus (SLE), Sjögren's syndrome, inflammation associated with gastrointestinal infections including C. difficile, viral myocarditis, acute and chronic tissue injury, non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, and renal diseases, including chronic kidney disease and diabetic kidney disease.

The present invention provides compositions and methods for treating, ameliorating or preventing liver diseases, particularly alcoholic liver diseases (e.g., alcoholic hepatitis, alcoholic liver failure) and drug-induced liver diseases, or related diseases and conditions.

The invention provides an application of a safflower seed meal extract in preparation of a medicine for preventing and treating alcoholic hepatitis, and relates to the technical field of medicines, and the medicine takes the safflower seed meal extract as a functional component and is used for preventing and treating the alcoholic hepatitis. Experimental research is carried out by establishing an alcohol-induced liver injury mouse model, and it is found for the first time that the safflower seed meal extract can effectively improve mouse liver injury caused by overuse of alcohol, relieve pathological injury and lipid accumulation caused by liver tissue inflammatory cell infiltration, improve the antioxidant capacity of liver tissue and restore liver functions; the raw materials are from by-products obtained after natural product safflower seeds are subjected to oil extraction, so that the raw materials are convenient to obtain, low in cost and high in safety.

25HC3S choline and crystalline 25HC3S choline are described herein.Further disclosed herein is the pharmaceutical preparation of 25HC3S choline, for example, using crystalline 25HC3S choline, and the method of using it to treat or prevent diseases, such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic hepatitis, acute kidney injury (AKI), psoriasis, atherosclerosis, hypercholesterolemia, hypertriglyceridemia, alcoholic fatty liver disease (AFLD), alcoholic steatohepatitis (ASH), leptin resistance, leptin deficiency, diabetic condition, autoimmune condition, inflammatory condition, neurological condition, Epstein-Barr virus-related proliferation and the condition related to fat accumulation and inflammation.Also provided is the method of preparing 25HC3S, including crystalline 25HC3S choline.

The invention discloses a traditional Chinese medicine decoction for treating alcoholic fatty liver, which is prepared by the following steps: pouring chrysanthemum, flower of kudzuvine, root of kudzu vine, lophatherum gracile, rhizoma anemarrhenae, turtle shell with vinegar, moutan bark, dendrobe, rhizoma polygonati with wine and parasitic loranthus as raw materials into a marmite, adding water until the water is 1-3 centimeters away from the surface of the medicine, and soaking for 30 minutes; and then boiling with strong fire, and decocting with soft fire for 30-40 minutes. And finally, taking 150 to 200 milliliters of medicine juice. The traditional Chinese medicine oral administration mode is adopted, the medicine compatibility is reasonable, the curative effect is unique, the cure rate is high, and the efficacy is direct and rapid. The effects of nourishing liver and kidney and nourishing yin and liver are achieved. The problem that the alcoholic fatty liver of a patient cannot be treated in time is developed into alcoholic hepatitis and even deteriorated into alcoholic cirrhosis is avoided.

Several salts of 25HC3S are provided, including crystalline salts of 25HC3S. Pharmaceutical formulations of the disclosed salts and methods for using them to treat or prevent diseases, such as nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), alcoholic hepatitis, acute kidney injury (AKI), psoriasis, atherosclerosis, hypercholesterolemia, hypertriglyceridemia, alcoholic fatty liver disease (AFLD), alcoholic steatohepatitis (ASH), leptin resistance, leptin deficiency, diabetic conditions, autoimmune conditions, inflammatory conditions, neurological conditions, Epstein-Barr virus-associated proliferation, and conditions associated with fat accumulation and inflammation, are also provided. Methods for preparing the disclosed salts are also provided.