Traditional Chinese medicine composition and application thereof in preparation of medicine for treating alcoholic hepatitis

Abstract

The invention discloses a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating alcoholic hepatitis. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: 15 to 20 parts of radix puerariae, 15 to 20 parts of rhizoma phragmitis, 15 to 20 parts of rhizoma imperatae, 10 to 15 parts of dried herba dendrobii, 6 to 10 parts of fructus citri sarcodactylis, 10 to 15 parts of herba pogostemonis, 15 to 20 parts of herba lophatheri, 6 to 10 parts of herb tea and 10 to 15 parts of pericarpium citri reticulatae. The research finds that the aqueous extract of the traditional Chinese medicine composition can remarkably improve alcoholic liver injury tissue edema and inflammatory cell infiltration, improve the alcohol metabolism capability of a body, relieve inflammatory response and reduce the oxidative stress level of liver tissue, so that the purposes of treating alcoholic hepatitis and protecting the liver are achieved.

Description

Technical Field

[0001] The present invention belongs to the technical field of biomedicine, and particularly relates to a traditional Chinese medicine composition and its application in preparing a drug for treating alcoholic hepatitis. Background Art

[0002] Alcoholic liver damage can lead to impaired liver function and symptoms such as fatigue. Initially, it usually presents as alcoholic fatty liver disease. If left untreated, it can progress to alcoholic hepatitis, and in severe cases, alcoholic liver fibrosis and cirrhosis. Severe alcohol abuse can induce extensive hepatocellular necrosis or even liver failure.

[0003] Currently, silybin is a commonly prescribed medication for alcoholic liver damage. This flavonolignan compound, isolated from the seeds of the Asteraceae plant, Silybum marianum, protects against liver damage caused by chemical toxins, food toxins, and drugs, promoting liver cell regeneration and repair. It is known as a "natural liver protector." It is suitable for treating chronic persistent hepatitis, chronic active hepatitis, early-stage cirrhosis, and hepatotoxicity.

[0004] However, since silybin belongs to the flavonoid lignan compound, it is almost insoluble in water and is usually taken orally in clinical use. This makes the human body's absorption of silybin very limited. In order to ensure that enough of the drug is absorbed, overdose is inevitable, leading to adverse reactions such as gastrointestinal discomfort and chest tightness. Summary of the Invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine composition and its use in preparing a drug for treating alcoholic hepatitis, thereby providing a safe and effective new approach for the treatment of alcoholic hepatitis.

[0006] In order to achieve the above-mentioned object of the invention, the technical solution of the present invention is as follows: The invention first provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials in parts by mass: 15-20 parts of kudzu root, 15-20 parts of reed root, 15-20 parts of cogongrass root, 10-15 parts of dried dendrobium, 6-10 parts of bergamot, 10-15 parts of patchouli, 15-20 parts of loblolly leaf, 6-10 parts of edible herbal tea, and 10-15 parts of tangerine peel.

[0007] The "three roots" (i.e., Pueraria root, Phragmites australis, and Imperata root) are the core and characteristic of this prescription, and serve together as the main medicine; among them, Pueraria root detoxifies alcohol, promotes fluid production and quenches thirst, and promotes the clear yang qi of the spleen and stomach. It can relieve thirst, irritability, and dizziness caused by alcohol, reduce the metabolic burden on the liver, and protect liver cells. It is an important medicine for detoxifying and protecting the liver; Phragmites australis clears heat and promotes fluid production, relieves irritability and stops vomiting, and promotes diuresis, clears liver, gallbladder, and stomach heat, and relieves stomach heat vomiting, dry mouth, and difficulty urinating caused by alcohol; Imperata root cools blood and stops bleeding, clears heat and promotes diuresis, clears damp-heat from the liver and gallbladder, promotes diuresis and reduces jaundice (for hepatitis jaundice), guides damp-heat out of the urine, and relieves liver inflammation; the three medicines work synergistically to target the core pathogenesis of alcoholic hepatitis - alcohol toxicity and damp-heat accumulating in the liver and gallbladder, clears heat and dampness, detoxifies and promotes diuresis, promotes fluid production and protects yin, and is the main force in expelling pathogenic factors.

[0008] Dried dendrobium nourishes the stomach, produces fluid, nourishes yin, and clears heat. Alcohol-induced dampness and heat can easily damage stomach and liver yin. Dendrobium nourishes damaged yin, relieves dry mouth and epigastric discomfort, protects the gastric mucosa, and complements the "three roots" in clearing heat without damaging yin. It also directly benefits liver cell repair. Patchouli aromatically dissolves dampness, harmonizes the stomach, stops vomiting, and stimulates the spleen and appetite. It targets symptoms such as dampness blocking the middle jiao, abdominal distension, nausea, and loss of appetite caused by alcohol-induced damage to the spleen and stomach. It invigorates spleen and stomach function, promotes digestion, and assists the monarch herb in dispelling dampness. Together, they complement the monarch herb, one addressing damp-heat damaging yin and the other dampness trapped in the spleen and stomach, enabling both dispelling pathogenic factors and strengthening righteousness, clearing heat and eliminating dampness, to work in unison. Codonopsis pilosula replenishes the middle jiao and invigorates qi, strengthening the spleen and lungs. Alcohol damages the spleen and stomach, and prolonged illness can easily lead to qi deficiency. Codonopsis pilosula replenishes spleen and stomach qi, enhancing the body's resistance to disease and repair capacity, preventing excessive effects of heat-clearing and dampness-removing herbs from damaging righteousness, and ultimately strengthening righteousness and dispelling pathogenic factors.

[0009] Buddha's hand and tangerine peel regulate qi and harmonize the middle, dry dampness and resolve phlegm, invigorate the spleen and stimulate the appetite. The two are used together to target qi stagnation (liver depression and qi stagnation, spleen and stomach qi stagnation), relieve symptoms such as distension and pain in the ribs, abdominal distension, and belching, and help patchouli to eliminate dampness and invigorate the spleen, and help codonopsis to strengthen the spleen and remove stagnation. When qi moves, dampness is transformed, and when qi moves, blood circulates, which is beneficial to the recovery of liver function; light bamboo leaves clear away heat and relieve restlessness, promote diuresis and relieve stranguria, enhance the heat-clearing and diuretic effects of the main drugs (especially reed root and white imperata root), make damp-heat evil qi more smoothly discharged through urine, and its heart-clearing and restlessness-relieving effects are also helpful for alcohol-induced heart disturbances; cold tea clears away heat and toxins, relieves exterior symptoms and expels wind, promotes fluid production and quenches thirst, stimulates the appetite and eliminates stagnation. In this prescription, it mainly plays the role of clearing internal heat (liver, gallbladder, and stomach heat), assisting the main drugs in enhancing the heat-clearing and detoxifying power, and also has a certain stomach-stimulating effect. Therefore, Codonopsis pilosula is an adjuvant (tonifying Qi and strengthening the body); Buddha's hand and dried tangerine peel are adjuvants (moving Qi to prevent stagnation and helping to dissipate dampness), also having an adjuvant effect; and bamboo leaves and herbal tea are adjuvants (enhancing heat-clearing, diuretic and detoxifying effects). Tangerine peel enters the spleen and lung meridians, and its Qi-regulating and spleen-strengthening properties help guide the various herbs to the middle jiao, spleen and stomach, enhancing the overall efficacy of the formula. Furthermore, its aromatic properties can harmonize the various herbs.

[0010] The compatibility characteristics of this prescription: 1. "Three roots" are the main ingredients, with distinct characteristics of detoxification and liver protection: Pueraria root detoxifies and produces body fluid, Phragmites australis clears heat, promotes diuresis and produces body fluid, Imperata root cools blood, promotes diuresis and reduces jaundice. The three medicines work together to directly target the core pathogenesis of alcoholic hepatitis.

[0011] 2. Use both clearing away heat, promoting the removal of dampness and detoxifying, while using Dendrobium to nourish Yin and prevent the removal of evil spirits from damaging Yin, which is in line with the pathological characteristics of damp-heat damaging Yin.

[0012] 3. While eliminating pathogenic factors, do not forget to strengthen the body’s health: While clearing away heat, promoting dampness and detoxifying (eliminating pathogenic factors), add Codonopsis pilosula to replenish Qi and strengthen the spleen, support the body’s health, and enhance disease resistance and repair capabilities.

[0013] 4. Pay attention to the smooth flow of Qi: Use bergamot and tangerine peel to promote Qi circulation, solve the problem of Qi stagnation caused by dampness and liver depression, so that Qi circulation can dissipate moisture, and Qi circulation can promote blood circulation, which is beneficial to the recovery of liver function and relief of symptoms.

[0014] 5. Eliminate dampness and heat through multiple pathways: Through the synergistic effects of clearing heat (kudzu root, reed root, white imperata root, bamboo leaves, cold tea), promoting dampness (reed root, white imperata root, bamboo leaves, tangerine peel, patchouli), detoxifying (kudzu root, cold tea), promoting qi (bergamot, tangerine peel), and invigorating the spleen (patches, tangerine peel, bergamot), dampness and heat can be effectively resolved and expelled.

[0015] This prescription has a relatively comprehensive combination design targeting the etiology and pathogenesis of alcoholic hepatitis (alcohol toxicity, damp heat stagnate in the liver and gallbladder, damage the spleen and stomach, and consume qi and yin), and embodies the treatment principle of "clearing heat, promoting dampness and detoxification as the main focus, and nourishing yin, promoting qi and strengthening the spleen as the auxiliary focus."

[0016] Experimental studies have found that the aqueous extract of this traditional Chinese medicine composition can significantly improve alcoholic liver damage tissue edema and inflammatory cell infiltration, improve the body's alcohol metabolism ability, reduce inflammatory response, and reduce the oxidative stress level of liver tissue, thereby achieving the purpose of treating alcoholic hepatitis and protecting the liver.

[0017] Based on this, the present invention also provides the use of the above-mentioned traditional Chinese medicine composition in the preparation of a drug for treating alcoholic hepatitis.

[0018] The alcoholic hepatitis syndromes applicable to the traditional Chinese medicine composition include alcoholic hepatitis of liver-gallbladder damp-heat type, alcoholic hepatitis of spleen-stomach deficiency type, alcoholic hepatitis of qi-yin damage type, alcoholic hepatitis of damp-heat stasis type and alcoholic hepatitis of liver depression and spleen deficiency type.

[0019] For patients with different syndromes, additions and subtractions can be made based on the above prescription.

[0020] For example, for patients with obvious jaundice, 25-35 parts of Artemisia capillaris, 10-15 parts of Gardenia jasminoides, and 15-25 parts of Plantago asiatica can be added; For patients with severe spleen deficiency, 10-20 parts of stir-fried Atractylodes macrocephala, 15-25 parts of Poria cocos, and 20-30 parts of raw Astragalus membranaceus can be added; For patients with obvious blood stasis, 15-25 parts of Salvia miltiorrhiza, 10-15 parts of red peony root, and 25-35 parts of Leonurus japonicus can be added.

[0021] Preferably, the above application comprises: adding 8-10 times of distilled water to the traditional Chinese medicine composition, refluxing and extracting at least twice, each time for at least 2 hours, filtering and combining the filtrates, concentrating and drying the filtrates, and using the obtained lyophilized powder to prepare a drug for treating alcoholic liver damage; Alternatively, water is added to the traditional Chinese medicine composition and boiled, and the obtained water decoction is used as a medicine for treating alcoholic hepatitis.

[0022] During medication, patients must strictly abstain from alcohol and maintain a healthy diet (low-fat, high-protein, and rich in vitamins). Mild cases require 21 days of continuous medication, while moderate to severe cases require 1-3 months of continuous medication. Long-term treatment is recommended for patients with fibrosis.

[0023] The freeze-dried powder can be made into a hangover-relieving tea for patients to drink. Therefore, the present invention also provides a hangover-relieving tea.

[0024] Preferably, the traditional Chinese medicine composition for preparing the hangover-relieving tea comprises, in addition to the above-mentioned raw materials, 10-12 parts of Amomum villosum, calculated by mass.

[0025] Preferably, the preparation method of the above-mentioned hangover-relief tea comprises: (1) adding 8-10 times of distilled water to the traditional Chinese medicine composition, reflux extraction at least twice, each time for at least 2 hours, filtering and combining the filtrates, concentrating and drying the filtrates to obtain lyophilized powder; (2) Dissolving the freeze-dried powder in water to obtain the hangover-relieving tea.

[0026] Compared with the prior art, the beneficial effects of the present invention are embodied in: The aqueous extract of the traditional Chinese medicine composition of the present invention can significantly improve alcoholic liver damage tissue edema and inflammatory cell infiltration, improve the body's alcohol metabolism ability, alleviate inflammatory response, and reduce the oxidative stress level of liver tissue, thereby achieving the purpose of treating alcoholic hepatitis and protecting the liver. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 The results of staining and analysis of mouse liver tissue pathology after treatment with different drugs; Wherein, Control represents the blank control group, Alcohol represents the model group, JJC-L represents the low-dose group (1 g / kg) of the hangover-relieving tea, JJC-M represents the medium-dose group (2 g / kg) of the hangover-relieving tea, JJC-H represents the high-dose group (4 g / kg) of the hangover-relieving tea, and Silymarin represents the positive drug group (silymarin); the same below; Figure 2 The results of liver coefficient analysis of mice after treatment with different drugs; Wherein, Liver coefficient (ratio to control) represents the liver coefficient (compared with the control group); Figure 3 The effects of different drug treatments on ALDH activity in mouse liver; Wherein, ALDH release refers to ALDH activity; the same below; Figure 4 The effects of different drug treatments on ADH activity in mouse liver; Figure 5 The effect of different drug treatments on the relative expression level of inflammatory factor TNF-α mRNA in mouse liver tissue; Relative expression of TNF-α mRNA refers to the relative expression level of TNF-α mRNA, the same below; Figure 6 The effect of different drug treatments on the relative expression level of inflammatory factor IL-1β mRNA in mouse liver tissue; Figure 7 The effect of different drug treatments on the relative expression level of inflammatory factor IL-6 mRNA in mouse liver tissue; Figure 8 The effects of different drug treatments on NO expression levels in mouse liver tissue; Figure 9 The effects of different drug treatments on the expression level of MDA in mouse liver tissue; Figure 10 The effects of different drug treatments on the expression level of SOD in mouse liver tissue; Figure 11 Effects of different drug treatments on CAT expression levels in mouse liver tissue. DETAILED DESCRIPTION

[0028] The technical solution of the present invention is further described in detail below with reference to the accompanying drawings and embodiments.

[0029] The Chinese herbal medicine slices involved in the embodiments of the present invention are provided by Lishui City Traditional Chinese Medicine Hospital, approved by the Chinese herbal medicine slice acceptance unit, and comply with the relevant provisions of the 2015 edition of the Chinese Pharmacopoeia. The details are as follows: Phragmites australis (specimen number #24090713), Imperata cylindrica (specimen number #240801), dried Dendrobium candidum (specimen number #2406018), Buddha's hand (specimen number #24110913), Codonopsis pilosula (specimen number #2510801), Patchouli herb (specimen number #2409002), Pueraria root (specimen number #241103), Bamboo shoots (specimen number #24111907), herbal tea (specimen number #zyy004), dried tangerine peel (specimen number #22082901), Amomum villosum (specimen number #240501).

[0030] Example 1 Preparation of hangover-relieving tea

[0031] The present embodiment provides a hangover-relieving tea, and the preparation method thereof comprises the following steps: (1) Weigh 5 g of Phragmites australis rhizome, 5 g of Imperata cylindrica root, 2.5 g of dried Dendrobium officinale, 2.5 g of Citronella bergamia, 2.5 g of Codonopsis pilosula (excellent), 2.5 g of Patchouli, 2.5 g of Pueraria root, 2.5 g of Bamboo leaves, 1.5 g of Herbal Tea (excellent), 2.5 g of Tangerine peel, and 3.0 g of Amomum villosum, add 10 times distilled water, reflux extract twice, each time for 2 h, filter, combine the filtrates, concentrate, and dry to obtain 0.364 g of freeze-dried extract powder (hereinafter referred to as JJC); (2) Dissolve the freeze-dried powder in a solvent (such as water, physiological saline, etc.) to obtain the hangover tea of ​​this embodiment.

[0032] Example 2 Analysis of the efficacy of hangover tea on alcoholic hepatitis

[0033] 1. Establishment of Alcoholic Liver Injury Mouse Model and Drug Administration Male C57BL / 6 mice (6-8 weeks old, weighing 18-20 g, registration number: SYXK2021-0026) were provided by Jiangsu Huachuang Xinnuo Pharmaceutical Technology Co., Ltd. Animal experimental procedures were approved by the Laboratory Animal Welfare and Ethics Committee of Jiangsu Hanjiang Biotechnology Co., Ltd. (Ethics Approval Number: HJSW-24101101) and complied with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. Mice were housed at Jiangsu Hanjiang Biotechnology Co., Ltd. under controlled environmental conditions (temperature: 25°C, relative humidity: 60%, 12-h light-dark cycle) and were acclimated to the animals for 7 days before subsequent experiments.

[0034] Starting on day 8, 50 mice were randomly divided into five groups (n=10): a blank control group (10 ml / kg saline by gavage), a model group (10 ml / kg saline by gavage), a hangover tea group (1 g / kg, 2 g / kg, and 4 g / kg of hangover tea by gavage), and a positive drug group (0.1 mg / kg silybin). On day 15, mice in the blank group were gavaged with distilled water, while mice in the other groups were gavaged with commercially available 50% ethanol (12 mL / kg × body weight) once daily for 7 consecutive days to induce acute alcoholic liver injury. Two hours after the last dose, mice were euthanized with pentobarbital, and liver tissue was immediately removed and weighed. The liver coefficient is calculated as liver weight divided by body weight.

[0035] 2. Histopathological analysis Liver tissue was removed from each mouse and fixed in 10% neutral buffered formalin for 24 h. Tissue samples were dehydrated and embedded in paraffin. Each tissue block was sectioned (5 μm) along its entire length and stained with hematoxylin and eosin (H&E). The staining results are shown in Figure 2. Figure 1 .

[0036] from Figure 1 It can be seen that the hepatic lobule structure of the blank control group mice's liver was clear, the hepatic cords were arranged in an orderly manner radially from the central vein outward, the hepatocytes were arranged in an orderly manner, and there was a complete nucleus in the center; compared with the blank control group, the hepatocytes of the model group mice's liver were randomly arranged, the hepatic cords were arranged disorderly, the tissue edema was obvious, and inflammatory cells were infiltrated; while the hangover tea group improved the liver tissue edema and inflammatory cell infiltration, and the improvement effect was comparable to that of the positive drug group.

[0037] 3. Liver coefficient analysis The degree of liver swelling in each group of mice after alcohol induction was measured and the liver coefficient was evaluated. Figure 2 shown.

[0038] from Figure 2 It can be seen that compared with the blank control group, the liver coefficient of the model group mice increased significantly ( P <0.01), indicating that ethanol-induced liver damage in mice was serious; while the hangover tea group was able to significantly reduce the liver coefficient of mice ( P <0.01), indicating that the hangover tea can effectively relieve the liver damage caused by alcohol, and the relief effect is comparable to that of the positive drug group.

[0039] 4. Analysis of ALDH and ADH activity in the liver In order to further explore the effect of hangover tea on alcohol metabolism, this example analyzed the ALDH and ADH activities in the liver of each group of mice. Figure 3 and Figure 4 .

[0040] As can be seen from the figure, compared with the blank control group, the activities of ALDH and ADH in the liver of mice in the model group decreased significantly ( P <0.01); while the activities of ALDH and ADH in the liver of mice in the hangover-detoxifying tea group and the positive drug group were significantly increased, indicating that the hangover-detoxifying tea can significantly improve the alcohol metabolism of mice, and the improvement effect is equivalent to that of the positive drug group.

[0041] 5. Analysis of inflammatory factor levels Inflammatory response is another important factor leading to liver damage. Therefore, in this example, the levels of inflammatory factors TNF-α, IL-1β and IL-6 in the liver tissues of mice in each group were analyzed. Figure 5 、 Figure 6 and Figure 7 .

[0042] As can be seen from the figure, compared with the blank control group, the mRNA levels of inflammatory factors TNF-α, IL-1β and IL-6 in the liver tissue of mice in the model group were significantly increased ( P <0.01), indicating that ethanol-induced liver inflammation in mice was severe; compared with the model group, the mRNA levels of inflammatory factors TNF-α, IL-1β and IL-6 in the liver tissue of mice in the hangover tea group were significantly decreased ( P <0.01), indicating that hangover tea can effectively reduce inflammatory response, and the inhibitory effect of the middle-dose group (2g / kg) and high-dose group (4g / kg) of hangover tea on inflammatory response is equivalent to that of the positive drug group.

[0043] 6. Analysis of oxidative stress levels In this example, the levels of NO, MDA, SOD and CAT in the liver of each group of mice were detected to analyze the oxidative stress level of each group of mice. The analysis results are shown in Figure 8 、 Figure 9 、 Figure 10 and Figure 11 .

[0044] As can be seen from the figure, compared with the blank control group, the expression levels of NO and MDA in the liver tissue homogenate of the model group mice were significantly increased ( P <0.01), the expression levels of SOD and CAT were significantly decreased ( P <0.01), indicating that alcohol-induced oxidative stress in the liver tissue of mice was significantly increased; however, this phenomenon was reversed in mice pretreated with hangover tea and silybin, indicating that hangover tea can protect mice from oxidative stress in the liver tissue caused by ethanol.

[0045] Example 3 Treatment of alcoholic hepatitis of liver-gallbladder damp-heat type by the traditional Chinese medicine compound of Patchouli and Dendrobium

[0046] Patient's symptoms: Mr. Zhang, a 45-year-old male sales manager, had a long-term alcohol consumption (approximately 200ml of baijiu daily for 6 years). He recently developed right flank pain, dry mouth, bitter taste, and dark urine. Liver function tests revealed ALT 158 U / L, AST 182 U / L, and GGT 210 U / L. His tongue was red, with a yellow, greasy coating, and a wiry, slippery pulse. Diagnosed with alcoholic hepatitis of the liver and gallbladder damp-heat type.

[0047] A traditional Chinese medicine compound of Patchouli and Dendrobium: 20g of Pueraria root, 20g of Phragmites australis root, 20g of Imperata root, 15g of dried Dendrobium, 10g of Citron, 12g of Codonopsis pilosula, 15g of Patchouli, 12g of Lophatherum gracile, 8g of herbal tea, and 12g of dried tangerine peel.

[0048] Decoction method: add 5 times the amount of water and boil for 2 hours, take 400ml of juice, and take it warm twice a day, morning and evening; during the medication period, you must strictly abstain from alcohol and adjust your diet (low-fat, high-protein, rich in vitamins).

[0049] Efficacy: After 21 days of continuous use, ALT, AST, and GGT levels dropped to 65 U / L, 78 U / L, and 120 U / L, respectively. Symptoms of flank pain and bitter taste in the mouth were significantly alleviated, urine became clear, and the tongue coating became thinner.

[0050] Example 4 Treatment of alcoholic hepatitis of spleen and stomach deficiency type with Patchouli and Dendrobium herbal compound

[0051] Patient's symptoms: Mr. Wang, a 50-year-old male, had a history of chronic alcoholism (1000ml of beer daily for 10 years) and presented with loss of appetite, abdominal distension, and loose stools. Liver function tests revealed ALT 98 U / L, AST 112 U / L, and low albumin (32 g / L). His tongue was pale, distended, with teeth marks along the edges, a greasy white coating, and a weak pulse. Diagnosed with alcoholic hepatitis of the spleen and stomach deficiency type.

[0052] A traditional Chinese medicine compound of Patchouli and Dendrobium: Pueraria root 15g, Phragmites australis 15g, Imperata root 15g, dried Dendrobium 12g, Citrus hand 8g, Codonopsis pilosula 15g, Patchouli 12g, Lophatherum gracile 10g, herbal tea 6g, and dried tangerine peel 15g.

[0053] Decoction method: add 5 times the amount of water and boil for 2 hours, 1 dose per day, divided into 2 doses; during the medication period, you must strictly abstain from alcohol and adjust your diet (low-fat, high-protein, rich in vitamins).

[0054] Efficacy: After 28 days of continuous use, abdominal distension was relieved, appetite improved, and stools became more formed. ALT and AST levels dropped to 45 U / L, 50 U / L, and albumin increased to 36 g / L.

[0055] Example 5 Treatment of alcoholic hepatitis of Qi and Yin deficiency type with Patchouli and Dendrobium herbal compound

[0056] Patient's symptoms: Mr. Li, a 55-year-old male with a 20-year alcohol history (he had quit drinking for three months), still experienced fatigue, dry mouth, and night sweats. His liver function was mildly abnormal (ALT 85 U / L, AST 90 U / L). His tongue was red and dry, and his pulse was thready and rapid. Diagnosed with alcoholic hepatitis of the Qi and Yin deficiency type.

[0057] A traditional Chinese medicine compound of Patchouli and Dendrobium: Pueraria root 18g, Phragmites australis 18g, Imperata root 18g, dried Dendrobium 15g, Citron 6g, Codonopsis pilosula 15g, Patchouli 10g, Lophatherum gracile 12g, herbal tea 6g, and dried tangerine peel 10g.

[0058] Decoction method: Add 5 times the amount of water and boil for 2 hours, 1 dose per day for 30 consecutive days; during the medication period, you must strictly abstain from alcohol and adjust your diet (low-fat, high-protein, rich in vitamins).

[0059] Efficacy: After 30 days of follow-up, ALT dropped to 40U / L, AST dropped to 42U / L, fatigue was relieved, and symptoms of dry mouth and night sweats were significantly improved.

[0060] Example 6 Treatment of alcoholic hepatitis of damp-heat and blood stasis type with a traditional Chinese medicine compound of Patchouli and Dendrobium

[0061] Patient's symptoms: Mr. Zhao, a 48-year-old male with a history of alcohol consumption (250ml of baijiu daily for 12 years), presented with stabbing pain in the liver area and a sallow complexion. Liver function tests revealed ALT 145 U / L, AST 168 U / L, and a Fibroscan liver stiffness of 8.5 kPa. His tongue was dark red with ecchymosis, his tongue coating was greasy and yellow, and his pulse was stringy and astringent. Diagnosis was based on damp-heat and blood stasis type alcoholic hepatitis (with mild fibrosis).

[0062] A traditional Chinese medicine compound of Patchouli and Dendrobium: 20g of Pueraria root, 20g of Phragmites australis root, 20g of Imperata root, 15g of dried Dendrobium, 10g of Citron, 12g of Codonopsis pilosula, 15g of Patchouli, 15g of Lophatherum gracile, 10g of herbal tea, and 15g of dried tangerine peel.

[0063] Decoction method: Add 5 times the amount of water and boil for 2 hours, 1 dose per day for 3 consecutive months; during the medication period, you must strictly abstain from alcohol and adjust your diet (low-fat, high-protein, rich in vitamins).

[0064] Efficacy: Three months later, ALT and AST levels dropped to 75 U / L, 82 U / L, and liver stiffness dropped to 7.2 kPa. The stinging pain in the liver area subsided, and the complexion became smoother.

[0065] Example 7 Treatment of alcoholic hepatitis of liver depression and spleen deficiency type with Patchouli and Dendrobium herbal compound

[0066] Patient's symptoms: Mr. Liu, a 40-year-old male, had quit drinking for six months but still experienced flank distension, depression, and poor appetite. Liver function tests showed ALT 65 U / L, AST 70 U / L. His tongue was pale red with a thin white coating and a thready, wiry pulse. Diagnosed with alcoholic hepatitis of the liver depression and spleen deficiency type (in the recovery phase after quitting drinking). A traditional Chinese medicine compound of Patchouli and Dendrobium: 15g of Pueraria root, 15g of Phragmites australis root, 15g of Imperata root, 10g of dried Dendrobium, 10g of Citron, 12g of Codonopsis pilosula, 10g of Patchouli, 10g of Lophatherum gracile, 6g of herbal tea, and 12g of dried tangerine peel.

[0067] Decoction method: Add 5 times the amount of water and boil for 2 hours, 1 dose per day for 21 consecutive days; during the medication period, you must strictly abstain from alcohol and adjust your diet (low-fat, high-protein, rich in vitamins).

[0068] Efficacy: After 21 days of follow-up, ALT dropped to 38U / L, AST dropped to 42U / L, flank distension and fullness were relieved, mood improved, and appetite increased.

Claims

1. A Chinese medicine composition, characterized in that Calculated by weight, the medicine comprises the following raw materials: 10-20 parts of kudzu root, 15-20 parts of reed root, 15-20 parts of imperata root, 10-15 parts of dried dendrobium, 6-10 parts of bergamot, 10-15 parts of patchouli, 15-20 parts of bamboo leaf, 6-10 parts of herbal tea, and 10-15 parts of tangerine peel.

2. The Chinese medicine composition according to claim 1, wherein Calculated by weight, the following raw materials are also included: 25-35 parts of Artemisia capillaris, 10-15 parts of Gardenia jasminoides, and 15-25 parts of Plantago.

3. The Chinese medicine composition according to claim 1, wherein Calculated by weight, the following raw materials are also included: 10-20 parts of stir-fried Atractylodes macrocephala, 15-25 parts of Poria cocos, and 20-30 parts of raw Astragalus membranaceus.

4. The Chinese medicine composition according to claim 1, wherein The following raw materials are also included by mass: 15-25 parts of Salvia miltiorrhiza, 10-15 parts of red peony root, 25-35 parts of Leonurus japonicus.

5. Use of the traditional Chinese medicine composition according to any one of claims 1 to 4 in the preparation of a drug for treating alcoholic hepatitis.

6. The use according to claim 5, characterized in that The alcoholic hepatitis includes alcoholic hepatitis of liver and gallbladder damp-heat type, alcoholic hepatitis of spleen and stomach deficiency type, alcoholic hepatitis of qi and yin damage type, alcoholic hepatitis of damp-heat stagnation type and alcoholic hepatitis of liver depression and spleen deficiency type.

7. The use according to claim 5, characterized in that include: Add 8-10 times of distilled water to the traditional Chinese medicine composition, perform reflux extraction at least twice, each time for at least 2 hours, filter and combine the filtrates, concentrate and dry the filtrates, and use the obtained lyophilized powder to prepare a drug for treating alcoholic hepatitis; Alternatively, water is added to the traditional Chinese medicine composition and boiled, and the obtained water decoction is used as a medicine for treating alcoholic hepatitis.

8. A hangover-relieving tea, characterized in that: The composition is prepared by the Chinese medicine composition according to any one of claims 1 to 4.

9. The hangover-relieving tea according to claim 8, characterized in that Calculated by weight, the traditional Chinese medicine composition further comprises 10-12 parts of Amomum villosum.

10. The hangover-relieving tea according to claim 8 or 9, characterized in that The preparation method comprises: (1) adding 8-10 times of distilled water to the traditional Chinese medicine composition, reflux extraction at least twice, each time for at least 2 hours, filtering and combining the filtrates, concentrating and drying the filtrates to obtain lyophilized powder; (2) Dissolving the freeze-dried powder in water to obtain the hangover-relieving tea.

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