48 results about "Tissue edema" patented technology

The invention provides systems and methods for neuromuscular electrical stimulation to muscle tissue. Stimulation electrodes may be provided on a stimulation pad, configured to provide electrical stimulation to a target tissue. A system for neuromuscular electrical stimulation may also include pressure generating mechanisms that may provide a compressive force to a region with the target tissue, thereby removing some excess third space fluid from the region.

The invention provides systems and methods for neuromuscular electrical stimulation to muscle tissue. Stimulation electrodes may be provided on a stimulation pad, configured to provide electrical stimulation to a target tissue. A system for neuromuscular electrical stimulation may also include pressure generating mechanisms that may provide a compressive force to a region with the target tissue, thereby removing some excess third space fluid from the region.

The invention relates to a preparing method of sodium aescinate, an external use preparation comprising the sodium aescinate,and application thereof, in particular to the preparing method of the sodium aescinate, preparation of the external use preparation and application to the preparation of medicine for preventing or treating tissue edema due to trauma. The preparing method is characterized by comprising extraction and separation and purification steps, wherein for the extraction, buckeye powder is extracted by 0-80-percent of ethanol or methanol solution (preferably methanol solution), the separation and purification step comprises the ion exchange chromatography by using inorganic sodium salt water solution as a flowing phase. The method has the advantages that the purity of prepared products is high, the production period is short, the cost is low, the problems such as environment pollution are avoided, and the like, and the method conforms to the development trends of preparing natural safe and high-purity aescin.

The invention discloses a quantitative fast frequency-locked magnetic resonance imaging method. Data acquisition of magnetic resonance imaging signals corresponding to different spin lock pulses in acontinuous scanning period is completed, and the data fills the same position in K space, so that T1rhomapping images finally obtained corresponding to the different spin lock pulses have high matching degree and can be used for judging tissue fibrosis indexes and diagnosing a tissue edema state; the effects of arrhythmia, uneven breathing and the like on the quality of the T1rhomapping images areminimized, and physical state and ability to suspend breathing and the like of a tester are not strictly required, so that scanning time required to obtain the T1rhomapping images is greatly shortened and the research and promotion of a T1rhomapping imaging technology in the field of clinical medical detection is further developed; in addition, the spin lock pulses alternate in positive and negative phases in adjacent RF excitation pulses, thereby effectively reducing artifacts due to magnetic field uniformity.

The present invention relates to an ultrasound equipment for treating edema, and more particularly, to an ultrasound equipment to relieve symptoms of edema or repair cellular and tissue edemas by generating 20˜400 mW / cm2 of low intensity ultrasound and use thereof.The ultrasound equipment according to the present invention comprises a main control unit equipped with a control unit for ultrasound generation for generating a 20˜400 mW / cm2 of low intensity ultrasound, an ultrasound generator for generating ultrasound according to the operating state of the main control unit, an ultrasound vibrator vibrating according to the value of ultrasound data inputted from the ultrasound generator, and a probe for delivering ultrasound energy to a treatment site, and when the ultrasound equipment is used, it is possible to treat edema by increasing permeability in blood vessels.

The invention belongs to the field of medical technologies and relates to a medical colloid dressing for preventing and treating human skin or tissue edema and pain and a preparation method thereof. In clinic treatment, the medical staff often adopts the method that gauze is soaked in a hypertonic solution and hydropathic compress is carried out to treat human skin or subcutaneous tissue edema caused by seepage or trauma during transfusion, the method is to be promoted in the therapeutic effect and is defective. According to the invention, the method that a water-soluble polymer is added is adopted, the hypertonic solution is converted into a colloid state, and the colloid dressing in the hypertonic state can promote the therapeutic effect better and overcomes the defects of hydropathic compress. When in use, the colloid dressing is tightly adhered to the skin or tissue of a swollen part, and an osmotic pressure difference is formed between the dressing and interstitial fluid in skin tissues, so that a part of water in the tissues of the swollen part is extracted in short time, damage to local tissue caused by edema is reduced, and the effects of local prevention and treatment are realized.

The invention discloses a method for establishing an acute lung injury animal model, and relates to the technical field of bioengineering. The method for establishing the acute lung injury animal model comprises the following steps: anesthetizing and fixing an experimental animal; inducing acute lung injury of the experimental animal by combining hydrochloric acid with mechanical ventilation; andevaluating the degree of acute lung injury. According to the method, acute pathological injury of the lung of the experimental animal is induced by combining hydrochloric acid with mechanical ventilation, the animal model of acute lung injury can be constructed, and the animal model shows typical characteristics of acute lung injury, such as dyspnea, lung tissue edema and lung tissue fibrosis. Themodel can be used for basic research in the related field of acute lung injury, and lays an experimental animal foundation for exploring the pathogenesis of acute lung injury.

The present invention relates to medicine, more particularly to pharmaceutical or cosmetic compositions, used for application on the skin, including the region of eyes, as well as on the lips and the mucosa of nasal, oral and laryngeal cavities of the man or the animal, with the purpose of preventing or reducing itch and local reaction from stings of insects, in particular mosquitoes, wasps, horse-flies etc. Local reaction from stings of insects is understood as pain, burning sensation, tissue edema, and hyperemia (redness around the sting site). The pharmaceutical or cosmetic composition, preventing or reducing the itch and the local reaction from the stings of insects, contains soluble salt or mixture of soluble salts of one or several rare earth elements, triethylene glycol, glycerine, polyethylene oxide, ethanol, sodium (potassium) hydroxide and water. When applied on the skin or the mucosa immediately after a sting, the composition leads within several tens of seconds to relief or entire disappearance of the itch, the pain and the burning, prevents edematization and then promotes disappearance of the edema. When the claimed composition is applied preventively, a prophylactic action on preventing or reducing manifestation of the itch and the local reaction from the stings is provided for 1-2 hours after the composition application.

The invention aims to provide a traditional Chinese medicine for treating and / or preventing gastrointestinal dysfunction caused by critical diseases. The traditional Chinese medicine is prepared from the following raw materials: radix codonopsis, fried largehead atractylodes rhizome, poria cocos, honey-fried licorice root, Chinese yam, white hyacinth bean, coix seed, villous amomum fruit, balloonflower root, pomegranate rind, myrobalan, and red halloysite. The traditional Chinese medicine is prepared according to the theories of tonifying qi, invigorating the spleen, upbearing the clear, and downbearing the turbid, has an integral conditioning effect by simultaneously eliminating and supplementing; can promote the peristalsis and propulsion of gastrointestinal smooth muscle, improves the blood circulation of the intestinal walls, reduces the capillary permeability of the gastrointestinal tracts, relieves the tissue edema, promotes the discharge of dead tissues, inhibits the intestinal bacterium translocation and toxin absorption in the intestines, eliminates the free radicals, and antagonizes the system inflammation reaction. The traditional Chinese medicine for treating gastrointestinal dysfunction caused by critical diseases has a good effect, can control the incidence rate of gastrointestinal dysfunction below 19.05%, does not have any side or toxic effect during the clinical process, and is reliable and safe.

The invention discloses bilirubin nanoparticles for treating acute pancreatitis and a preparation method thereof. The nanoparticles are mainly composed of silk fibroin, bilirubin, genipin and ceramide. The method comprises the steps that firstly, the bilirubin, the genipin and the ceramide are dissolved in a mixed organic reagent; secondly, the silk fibroin is dissolved in an aqueous solution, then the mixed solution of the bilirubin, the genipin and the ceramide is slowly added into the silk fibroin solution dropwise and continuously stirred, the organic solvent is removed through dialysis, and an obtained nanoparticle suspension is diluted with pure water to obtain the bilirubin nanoparticles. The bilirubin nanoparticles can be used for treating acute pancreatitis and relieving tissue edema caused by pancreatitis, can be applied to preparation of medicines for treating acute pancreatitis, and has wide clinical application prospects.

The invention discloses a medical bandage for dressing a wound. The medical bandage comprises a bandage body; the bandage body is provided with an outer layer; the outer layer is formed by weaving an elastic flat ribbon; a first layer of elastic cotton thread knitted sheet is adhered to the middle position on the inner surface of the outer layer; a second layer of elastic cotton thread knitted sheet is adhered to part of the peripheral edge of the first layer of elastic cotton thread knitted sheet; the first layer of elastic cotton thread knitted sheet and the second layer of elastic cotton thread knitted sheet are separated from each other to form a cavity with an opening; a traditional Chinese medicine pad with effects of relieving pain, dispersing blood stasis and promoting blood circulation can be placed and accommodated in the cavity with the opening and can also be taken out of the cavity with the opening. After the medical bandage is used for dressing the wound, pain of a patient is relieved, tissue edema is diminished and the wound is promoted to be healed; consumption of materials for making the medical bandage is reduced; comfort for the patient is improved; the medical bandage is also convenient to rapidly dress.

The invention belongs to the field of biological medicine and relates to polypeptide fragment derived from intermedin (IMD; alternate name, Adrenomedullin 2, ADM2). The polypeptide fragment is specifically mature peptide IMD108-147 with the length of 40 amino acids. Researches show that intermedin precursor peptide and three kinds of sheared manure peptides can reduce cytokine storm caused by sepsis, have a protection effect on vascular endothelial barriers, can reduce tissue edema and organic damage, can effectively reduce death rate of the sepsis. The IMD108-147 related in the invention has possibility of serving as polypeptide medicine to be applied to preventing and treating clinical sepsis and has a very good application prospect.

The invention relates to the technical field of medical instruments, and discloses an extendable anti-reflux pancreatic stump anastomosis supporting tube which solves the problems that in the current pancreatic stump anastomosis operation, the risk of cracking cannot be avoided in pancreatic intestine or pancreatic stomach anastomosis, anastomotic fistula is caused, and then pancreatic fistula occurs. The extendable anti-reflux pancreatic stump anastomosis support tube comprises a supporting outer sleeve, one end of the supporting outer sleeve is connected with an anti-reflux assembly, a supporting inner sleeve is connected into the end, away from the anti-reflux assembly, of the supporting outer sleeve, and a connecting film is connected between the supporting inner sleeve and the supporting outer sleeve. When an anastomotic stoma does not crack, the support tube device only plays a role of the anti-reflux support tube; when the anastomotic stoma cracks, the support tube can still maintain the drainage function of a main pancreatic duct-small intestine cavity or gastral cavity, and when edema of peripheral tissue of the anastomotic stoma gradually fades away, the anastomotic stoma gradually heals, and the support tube gradually returns to the unstretched state; and pancreatic fistula is avoided by applying the support tube, and extensibility is achieved.

The invention researches the anti-inflammatory activity of DSS (Dextran Sulfate Sodium) inducted colitis model for paeoniflorin and paeoniflorin metabolism pigment I. An experiment result indicates that the paeoniflorin metabolism pigment I has a good treatment effect on ulcerative colitis. Compared with a control group and a paeoniflorin group, a C57BL / 6 mouse which orally takes the paeoniflorinmetabolism pigment I, the paeoniflorin metabolism pigment I is characterized in that a colon tissue damage degree is lightened, the mouse colon tissue damage degree of the low and high dosage medication administration team of the paeoniflorin metabolism pigment I is lightened, a tissue structure is clear in level, the infiltration of inherent layer inflammatory cells is reduced, the amount of cup-shaped cells is relatively increased, muscularis mucosa does not contain tissue edema and hyperaemia, and tissue forms are obviously recovered. The paeoniflorin metabolism pigment I is proved to havea good treatment effect on the ulcerative colitis.

The invention belongs to the technical field of medicine, and specifically discloses an acute lung injury treating pharmaceutical composition, and uses of a compound having a structure represented bythe following formula defined in the specification in preparation of acute lung injury treating drugs, wherein R1, R2 and R3 can be the same or different groups. Patients with acute lung injury have pathological changes such as pulmonary alveolus structure destruction, pulmonary interstitial congestion and edema, massive inflammatory cell infiltration and the like. According to the present invention, the acute lung injury treating pharmaceutical composition can improve the symptoms of the patients with acute lung injury, reduce lung tissue edema and inflammatory cell exudation, and reduce thehistopathological score of lung tissue, wherein the longer the action time, the more significant the protection effect on lung.

The invention relates to a bandaging and fixing device after a skin-grafting surgery, and belongs to the technical field of medical apparatuses. The bandaging and fixing device is composed of an adsorption loop, a pressing cover and an air bag, the air bag is arranged on the bottom of the pressing cover, a pressing plate is movably arranged between the air bag and the pressing cover, and the adsorption ring is arranged on the periphery of the lower surface of the pressing plate arranged on the periphery of the air bag. The bandaging and fixing device can adjust bandaging pressure by controlling inflating volume of the air bag, balance pressure suffered by the grafted skin, so that the grafted skin can tightly fit skin tissue defect wound surfaces, and effusion can be absorbed by the adsorption loop arranged on the pressing cover, so that it is beneficial to subside tissue edema and promote granulation tissues neogenesis in the wound surfaces; survival rate of the grafted skin is further improved; the problem is solved that existing uneven pressure causes avascular necrosis of the grafted skin, and the bandaging and fixing device after the skin-grafting surgery has the advantages ofsimple structure and good practicability, and is particularly applicable to bandaging and fixing use after the skin-grafting surgery.

The invention discloses an adjustable suture including a micro locking mechanism and a suture main body. The micro locking mechanism is composed of a shell body, a limit plate and a pressure limitingwheel. The outer wall at one end of the shell body is fixedly connected with a suture fixing ring, and one end of the suture main body is wound on the ring wall of the suture fixing ring for fixed connection. The adjustable suture has the beneficial effects that after suturing or ligating a tissue, the adjustable suture can be stretched along with the tissue edema and other conditions and can alsobe shortened with the tissue edema subsiding, so as to make the tissue keep relatively long-lasting pressure in the healing process; the suture is a low-tension suture and has slow cutting effect onthe tissue. On the other hand, with the arranged micro locking mechanism and the height elasticity of the suture, after the tissue is sutured or ligated and fixed, the suture can be loosened when thetension is greater than the set range, so that the tension can reach the set range, the suture can be tightened when the tension is less than the set range, and the tension can reach the set range.

The invention discloses a pharmaceutical composition for treating burn and scald as well as a preparation method thereof. The pharmaceutical composition comprises the following raw materials in partsby weight: 60 parts of barley pest essential oil, 10 parts of coptis, 10 parts of phellodendron, 6 parts of gentrin knotweed, 5 parts of raw garden burnet, 3 parts of red flower, 5 parts of lithospermum, and 1 part of borneol. Through clinical observation, a dressing formula of the pharmaceutical composition has functions for resisting inflammation and relieving pain, mitigating tissue edema, promoting wound blood circulation, protecting mesenchymal ecological tissue to outcome to a good condition, reducing bleedout, accelerating dissolving of necrotic tissue, satisfying the oxygen and nutrients supply for wound, promoting wound healing, and reducing the scar formation.

The invention discloses a microcirculation pulse blood flow monitoring system and method used for liquid therapy and capacity management, and belongs to the technical field of medical treatment monitoring. The monitoring system comprises a data collecting module, a storage module and a comparison module. At different times, repeated positioning is conducted on blood capillaries in the same monitored region, and blood vessel image data is collected and stored; the measurement data of blood vessel images collected at different times are compared, the number of blood vessels where pulse blood flow occurs and / or the speed of pulse blood flow and / or the frequency of pulse blood flow occurrence are used as indexes for making capacity management and liquid therapy accurate, and the problem is solved that liquid therapy and capacity management lack clinical golden indexes. Through the monitoring system, a heart failure, pulmonary edema and tissue edema of lungs caused by excessive transfusionare avoided, the burden of kidneys is reduced, transfusion time is shortened, treatment costs are lowered, and the pains of patients are relieved.

A kinesiology tape having nonlinear gradient biological mechanical characteristics is disclosed. The kinesiology tape includes a substrate having nonlinear gradient material performance, a two-dimensional wave-shaped glue layer and common release paper. The kinesiology tape is spindle-shaped or triangle as shown in attached drawings 1-3. By utilizing a fact that the nonlinear gradient material performance can reduce the wrinkle rate and enhance biological breathable effects during movement processes, a series of mechanical protection can be achieved, such as increase in muscle eccentric contraction force generation, exercise fatigue time prolonging, and movement impact damage reducing. In addition, a muscle-like shape design effectively improves the traction efficiency for muscles, and thetwo-dimensional wave-shaped glue layer can relieve tissue edema to a certain degree.

The invention discloses a backache relieving capsule for treating backache and a preparation method thereof. According to different traditional Chinese medicine characteristics, ephedra stem, pawpaw, herba epimedii, radix angelicae pubescentis, notopterygium root, bark of eucommia, rhizoma cibotii, clematis root, achyranthes root, licorice root, dragon's blood, prepared semen strychni, prepared bitter orange, ground beetle, scorpion, pseudo-ginseng, muscardine silkworm and colchicine as raw materials are respectively subjected to processing and extraction, the extraction products are blended according to a certain ratio, and the mixture is processed to form the capsules. Through combination of Chinese and western medicines, the backache relieving capsule has effects of strengthening muscles and bones, relaxing muscles and stimulating blood circulation, and dispersing blood stasis and relieving pain. The backache relieving capsule is used for treating lassitude in loin and legs and limb numbness caused by protrusion of lumbar intervertebral disc, sciatica and lumbar muscle degeneration, can fast promote nucleus pulposus water loss shrinking and fast elimination of tissue edema around a nerve root, realizes double effects and simultaneous treatment of principal and subordinate symptoms, and innovates a very convenient, safe and economic oral premedication treatment method for treating lumbar disc herniation.

The invention discloses ephedra, cassia twig, scorpion, centipede and woodlouse powders for treating lumbar intervertebral disc protrusion through a two-step method, and relates to traditional Chinese medicine powders for treating lumbar sprain and lumbar disc herniation. The ephedra, cassia twig, scorpion, centipede and woodlouse powders can treat lumbar sprain through the two-step method. In the first step, an ephedra and cassia twig juicing method is adopted to prompt a nucleus pulposus protrusion to retract so as to release the oppressed state of adjacent nerve roots and eliminate tissue edema around spinal cord and the spinal stenosis, so that pains of a patient that arrests sweating can be reduced immediately, and immediate effect can be achieved. In the second step, the scorpion, centipede and woodlouse powders are taken orally for one or two courses of treatment, each course of treatment contains ten days so as to restore broken fiber rings, and the disease can be healed thoroughly without recurrence. Ephedra and cassia twig are taken and ground to obtain fine powders that are 100 meshes (monopack), and scorpion, centipede and woodlouse are taken and ground to obtain fine powders that are 100 meshes (monopack). The ephedra and cassia twig powders are taken orally in the first day in the first course of treatment, and the patient covers a quilt for sweating. The scorpion, centipede and woodlouse powders are taken orally from the second day to the eleventh day, are taken two times a day in morning and evening respectively. After the first course of treatment, the patient suffered from the disease for a long time can take the powders for the second course of treatment, so as to achieve healing.

The invention relates to a use of nicotinamide mononucleotide in preparation of a drug for prevention and / or treatment on rtPA vascular complication. rtPA is an important thrombolytic drug for treating acute myocardial infarction, pulmonary embolism and cerebral infarction, can easily produce untoward effects in clinical application and has obvious tendency of destroying a blood vessel barrier structure and inducing vascular complication such as bleeding. Based on a mouse vascular complication model caused by injection of rtPA, the protective effect of nicotinamide mononucleotide on rtPA-damaged blood vessels is researched. An experimental result shows that nicotinamide mononucleotide can significantly improve mouse blood extravasation caused by injection of rtPA, reduce tissue edema and increase expression of a blood vessel tight junction protein so that nicotinamide mononucleotide can resist rtPA-caused angiolysis and vascular complication.

A corneal tissue culture system and a corneal tissue culture method for increasing corneal endothelial cell density, healing of damaged corneal endothelial cell, and stimulating corneal endothelial cell proliferation are disclosed. The corneal tissue culture system comprises a tissue culture medium and a tissue culture dish to reduce metabolic pressure and reduce corneal tissue edema.

The invention discloses an adjustable suture, which includes a miniature locking mechanism and a suture main body. The miniature locking mechanism is composed of an outer shell, a limiting plate and a pressure limiting wheel. The outer wall at one end of the outer shell is fixedly connected to There is a suture fixing ring, and one end of the suture main body is wound on the ring wall of the suture fixing ring for fixed connection. The beneficial effect achieved by the present invention is: after the adjustable suture of the present invention is sutured or ligated tissue, With tissue edema and other conditions, it can be stretched, and can also be shortened with the subsidence of tissue edema, so that the wound can maintain a relatively long-lasting pressure during the healing process of the tissue. This suture is a low-tension suture that has a slow effect on tissue cutting. On the other hand, the present invention uses the micro-locking mechanism provided and the high elasticity of the suture itself. After suturing or ligating the fixed tissue, the suture can be loosened when the tension is greater than the set range, so that the tension reaches the set value range, and when the tension is less than The setting range can tighten the suture so that the tension reaches the setting range.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine formula for antagonizing cerebral vascular excessive dilatation and a preparation method thereof.The traditional Chinese medicine formula is composed of 1-35 parts of lignum dalbergiae odoriferae, 1-35 parts of radix curcumae, 1-35 parts of rhizoma chuanxiong, 1-35 parts of rhizoma acori graminei, 1-35 parts of radix aucklandiae and 1-35 parts of radix salviae miltiorrhizae. The formula is used for antagonizing cerebrovascular dilatation caused by various pathological factors, inhibiting loss of vascular smooth muscle and reducing dilatation exudation and hemorrhage, so that perivascular tissue edema is inhibited, oppression pain caused by vascular dilatation is relieved, and general families can prepare the traditional Chinese medicine by themselves through the provided preparation method and equipment.

The invention discloses application of ectoine and / or hydroxyectoine to preparation of a burn and scald treatment drug. The ectoine and / or hydroxyectoine can effectively promote wound healing of burnsand scalds, shorten healing time, regulate and control collagen synthesis, prevent scar tissue caused by ratio imbalance and abnormal accumulation of collagen fiber, inhibit release of inflammatory factors, reduce wound exudation and pus accumulation, relieve wound tissue edema, reduce wound sensitivity, relieve pain and pruritus in a debridement process and a wound healing process and alleviatepatients' pain.

The invention researches the anti-inflammatory activity of DSS (Dextran Sulfate Sodium) inducted colitis model for paeoniflorin and paeoniflorin metabolism pigment I. An experiment result indicates that the paeoniflorin metabolism pigment I has a good treatment effect on ulcerative colitis. Compared with a control group and a paeoniflorin group, a C57BL / 6 mouse which orally takes the paeoniflorinmetabolism pigment I, the paeoniflorin metabolism pigment I is characterized in that a colon tissue damage degree is lightened, the mouse colon tissue damage degree of the low and high dosage medication administration team of the paeoniflorin metabolism pigment I is lightened, a tissue structure is clear in level, the infiltration of inherent layer inflammatory cells is reduced, the amount of cup-shaped cells is relatively increased, muscularis mucosa does not contain tissue edema and hyperaemia, and tissue forms are obviously recovered. The paeoniflorin metabolism pigment I is proved to havea good treatment effect on the ulcerative colitis.

The invention provides a pharmaceutical composition as well as a preparation method and application thereof and belongs to the field of drugs. The pharmaceutical composition is a mixed extract of hypecoum leptocarpum and oxytropis. The pharmaceutical composition can achieve the effects of inhibiting the allergic reaction of the body and local tissue edema caused by allergic media and enhancing thevascular permeability. Meanwhile, the pharmaceutical composition is capable of obviously prolonging latent time of cough and has an obvious effect of inhibiting the cough. In addition, the pharmaceutical composition is capable of obviously promoting tracheal membrane secretion ability and has an obvious effect of irritating the upper respiratory tract to promote sputum excretion. Therefore, the pharmaceutical composition can be used for preparing medicines with effects of resisting allergy, relieving cough, eliminating phlegm and the like, is particularly applicable to preparation of medicines used for treating asthma and allergic rhinitis and has wide application prospects.