14 results about "Tissue edema" patented technology

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a traditional Chinese medicine compound antibacterial gel for promoting blood circulation to remove meridian obstruction and a preparation method thereof. The traditional Chinese medicine compound antibacterial gel for promoting blood circulation to remove meridian obstruction is prepared from the following components in percentage by mass: 0.01 to 0.03 percent of benzalkonium chloride, 0.02 to 0.05 percent of aromatic phenol acetate, 1 to 2.5 percent of propylene glycol, 0.01 to 0.05 percent of menthol, 0.3 to 0.6 percent of traditional Chinese medicine extracting solution, 0.01 to 0.05 percent of ginger root oil, 0.5 to 1 percent of pandan butyl ether, 0.01 to 0.05 percent of borneol, 0.3 to 5 percent of modified hydroxyethyl cellulose and the balance of water. The gel can relieve tissue edema and improve microcirculation and tissue oxygen supply; meanwhile, by combining with antibacterial components, the anti-infection effect can be synchronously achieved, the effects and advantages of promoting blood circulation and dredging collaterals of the traditional Chinese medicine compound are complementary, the better treatment effect is achieved, and the wound healing quality and speed are improved.

The invention provides a traditional Chinese medicine composition for preventing or treating prostatitis and a preparation method and application thereof, and belongs to the technical field of health care medicines. The traditional Chinese medicine composition is prepared from the following components: semen plantaginis, herba taraxaci, radix sophorae flavescentis, cortex phellodendri, radix salviae miltiorrhizae, radix et rhizoma rhei, radix rehmanniae praeparata, fructus ligustri lucidi, semen cuscutae, herba cistanche, fructus lycii extract, longan extract, membrane of hen egg, fructus ziziphi jujubae extract, honey and rice fermentation filtrate. The traditional Chinese medicine composition is in a liquid dosage form prepared by a process including fermentation treatment. The traditional Chinese medicine composition prepared by the invention can relieve prostate tissue edema of a prostatitis model rat in a dose-dependent manner and reduce a prostate wet weight index, so that the traditional Chinese medicine composition has a certain improvement effect on prostate tissue hyperplasia and inflammatory swelling caused by chronic abacterial prostatitis.

The invention discloses a step locking type disposable circumcision anastomat and an application method thereof, and particularly relates to the technical field of circumcision anastomats.The step locking type disposable circumcision anastomat comprises an outer ring and an inner ring which are connected in a sleeved mode, the outer ring comprises a first half ring and a second half ring, and the first half ring and the second half ring are oppositely arranged and can be closed to form an annular structure; a first limiting block is arranged on the outer side of the first half ring, and a second limiting block is arranged on the outer side of the second half ring. The ladder-shaped clamping groove is matched with the clamping block, so that reliable locking is provided. The problem of springback or slipping possibly caused by traditional locking depending on single elastic deformation is solved, the state is stable after locking, loosening caused by movement or tissue edema fading of a patient is not prone to occurring, the operation effect is ensured, and secondary operation risks such as bleeding and poor healing caused by loosening of an anastomotic stoma are avoided. The clamping block is matched with the stepped clamping groove, and is mainly used for overcoming the longitudinal opening force generated by the girdling blade during cutting and anastomosis.

The present invention provides a composition comprising 5-aminolevulinic acid or a salt or ester thereof, comprising: (a) an active ingredient selected from 5-aminolevulinic acid or a salt or ester thereof; and (b) an aqueous carrier comprising an analgesic. The 5-aminolevulinic acid or the salt or ester thereof can be used for photodynamic therapy analgesia for more than 20 minutes, so that the clinical treatment cycle can be covered, the pain feeling after photodynamic therapy can be obviously relieved, the photodynamic therapy receiving time of a patient is prolonged, and the medication compliance of the patient is improved. Moreover, the composition provided by the invention can also improve the condition of tissue edema after photodynamic therapy, improve the skin smoothness after photodynamic therapy and shorten the pigmentation time, and meanwhile, compared with a marketed preparation, the composition has a better effect in the aspect of photodynamic therapy of inflammatory diseases (such as psoriasis or contact dermatitis) or acne and the like, and has a good application prospect. The acceptability of the patient to the photodynamic therapy is further improved; and the application scene of the photodynamic therapy is widened.

The invention discloses a method for reducing impedance measurement drift through a high-linearity sensor, relates to the technical field of electrical variable measurement, and aims to solve the technical problem that drift of existing equipment exceeds the standard due to multi-source interference and poor adaptability. The multi-modal sensing system comprises a high-linearity impedance sensor, a near-infrared spectrum sensor and a micro-pressure sensor, and the multi-modal sensing system synchronously collects an impedance signal, a blood oxygen saturation signal and a probe attaching pressure signal of a biological tissue; and S2, performing coupling analysis on the acquired impedance signal, the acquired oxyhemoglobin saturation signal and the acquired probe attachment pressure signal, distinguishing different types of interference sources of tissue edema, skin sweat interference and environmental electromagnetic interference, and removing false impedance drift signals in a targeted manner to obtain a real impedance measurement signal. The method has the advantages that the impedance measurement drift is reduced, and the stability, continuity and adaptation precision of signals in long-term monitoring are improved.

The invention provides a brain tissue edema degree characterization method which comprises the following steps: controlling a cylindrical pressure head to be pressed into an experimental module at a constant rate, and transmitting a signal to a computer by a sensor to obtain a force-displacement curve. And calculating the relaxation amount of the experiment module according to the force-displacement data. The water content in the brain can be qualitatively represented through the obtained mechanical parameters, so that the edema degree of brain tissues is represented. The method not only can realize the characterization of the edema degree of the brain tissue, but also is beneficial to the precision of the measurement technology, accurate data and reliable performance, and can be used for speculating the cause of the edema of the brain.

The invention discloses a wireless neural signal recording and stimulating system, relates to the technical field of medical and physiological signal detection and processing analysis, and provides the following scheme that the wireless neural signal recording and stimulating system comprises a data synchronous acquisition module, a signal processing module and a signal processing module, the synchronous acquisition module is used for synchronously acquiring original stimulation pulse waveforms and tissue impedance distribution data, and the biological conduction modeling module is used for combining the tissue impedance distribution data based on frequency parameters of the original stimulation pulse waveforms. According to the invention, a cross-correlation function of a mixed signal and a basic artifact waveform is calculated to capture microsecond-level time delay offset, time axis translation calibration is carried out according to a cross-correlation peak value, and a dynamic gain factor is generated based on an amplitude difference between the waveform after translation and the mixed signal. The problems of time delay drifting caused by cerebrospinal fluid flowing and electrode micro-displacement and amplitude drifting caused by tissue edema are synchronously solved, and space-time dynamic matching of a stimulation artifact waveform and a real-time electric signal environment in a living body is achieved.

The invention provides composite plant powder with an effect of eliminating edema and a preparation method and application thereof, and the composite plant powder with the effect of eliminating edema comprises the following raw material components in parts by weight: 5-10 parts of corn stigma powder, 0.0005-0.005 part of red bean powder, 1-5 parts of opuntia ficus-indica juice powder, 1-5 parts of seaweed meal, 0.0005-0.005 part of coix seed powder, 1-5 parts of gordon euryale seed powder and 0.0005-0.005 part of poria cocos powder. According to the composite plant powder provided by the invention, all the components are matched for use and have a synergistic effect, so that the composite plant powder can jointly act on three aspects of promoting kidney to induce diuresis and drain water, resisting inflammation to relieve tissue edema and regulating intestinal flora to improve in-vivo water balance and the like, and thus the composite plant powder has a good edema eliminating effect.

The application belongs to the technical field of biological medicine, and discloses a spinal cord injury treatment drug based on a LINC00311 / miR-4318 / MYLK regulation axis and an application thereof, and aims to solve the technical problems of poor targeting and large side effects of the existing anti-inflammatory treatment of spinal cord injury. The effective component of the drug is an inhibitor of LINC00311, the inhibitor is selected from one or more of shRNA, siRNA, antisense oligonucleotide and CRISPRi system, can target the specific nucleotide sequence of LINC00311, and can be used in combination with miR-4318 mimic, and is administered by intrathecal injection, slow virus carrier delivery and the like. The in-vitro experiment proves that the inhibitor can significantly inhibit the release of TNF-alpha, IL-1beta, IL-6 and other pro-inflammatory factors by microglia cells; the in-vivo experiment shows that it can significantly improve the BBB motor function score of spinal cord injury rats, and reduce spinal cord tissue edema and necrosis. The application first discloses the mechanism of the LINC00311 / miR-4318 / MYLK ceRNA regulation axis in spinal cord injury, has the advantages of novel target, significant effect and high transformation potential, and provides a new scheme for the clinical treatment of spinal cord injury.

The invention belongs to the technical field of biological medicine, and discloses a zanthoxylum nitidum-sourced external vesicle, a preparation method and an application in preparation of a medicine for preventing and treating acute lung injury, and the external vesicle with the particle size of 60-100 nm and a lipid bilayer structure is extracted and purified from the root of zanthoxylum nitidum for the first time. The external vesicle can be administered in modes of aerosol inhalation and the like, and shows an excellent curative effect in an acute lung injury model: lung tissue edema and inflammatory cell infiltration can be remarkably relieved, levels of key proinflammatory factors such as IL-6, TNF-alpha, IL-1beta and the like in serum are reduced, macrophages are promoted to be differentiated to an anti-inflammatory M2 type, and the curative effect is remarkable. The treatment effect is better than that of traditional dexamethasone, and the side effect is lower. The invention provides a brand-new, efficient and safe candidate drug and a natural nano treatment strategy for preventing and treating acute lung injury and ARDS.

Embodiments are directed to an automated system that provides statistical confirmation of the non-infiltrated state of a functioning PIV and a clear signal associated with an infiltrated PIV identifying conditions associated with infiltration / extravasation before rather than after the onset of a noxious event such as tissue edema or damage.

Embodiments are directed to an automated system that provides statistical confirmation of the non-infiltrated state of a functioning PIV and a clear signal associated with an infiltrated PIV identifying conditions associated with infiltration / extravasation before rather than after the onset of a noxious event such as tissue edema or damage.

The invention relates to the technical field of nasal disease treatment, in particular to a plant composition for treating nasal polyp and nasal gland hypertrophy, which is prepared from the following raw material medicines in parts by mass: 10 to 15 parts of flos magnoliae, 8 to 12 parts of radix angelicae, 10 to 20 parts of radix scutellariae, 15 to 25 parts of honeysuckle flower, 10 to 18 parts of fructus forsythiae, 5 to 10 parts of radix platycodonis, 3 to 8 parts of herba menthae, 10 to 20 parts of herba houttuyniae and 5 to 12 parts of herba centipedae. And the following active extraction components in parts by weight: 1-3 parts of bromelain, 0.5-2 parts of quercetin, 0.5-1.5 parts of curcumin and 1-4 parts of a frankincense serrata serrata extract. Nasal cavity inflammation and tissue edema are effectively relieved through a combined effect, firstly, flos magnoliae and radix angelicae in the formula can dissipate wind-cold, dredge nasal orifices and directly improve the ventilation function of the nasal cavity, meanwhile, radix scutellariae, honeysuckle and other medicinal materials clear away damp-heat toxin in the body through the effects of clearing away heat and drying dampness, inflammatory response is inhibited from the source, and the effect is remarkable. By matching with modern active ingredients such as bromelain and curcumin, the release of inflammatory mediators can be further blocked, and the capillary permeability is reduced.

The present application aims to develop an animal model which can focus on the core symptoms of acute lung injury and can well evaluate the drug efficacy of acute lung injury. The rat acute lung injury model constructed in the present application shows a high success rate and stability in inducing classic symptoms of acute injury (dyspnea, pulmonary edema and pulmonary fibrosis, etc.), as well as symptoms such as depression, alveolar atrophy, alveolar inflammatory infiltration, and reduced blood oxygen of acute lung injury. In the construction method of the rat acute lung injury model of the present application, the rat acute lung injury model is obtained by intraperitoneal injection of cholic acid and mixed solution of polyethylene glycol and polysorbate + heat stress + silica intake + exercise induction. This non-single factor induced acute lung injury animal model is consistent with the etiology that acute lung injury is induced by multiple factors, and can better simulate the characteristics of human acute lung injury.