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Traditional Chinese medicine formula for antagonizing cerebral vascular hyperdilatation and preparation method

A technology of cerebrovascular and traditional Chinese medicine, which is applied in the prescription and preparation of traditional Chinese medicine for antagonizing the excessive expansion of cerebral blood vessels. Arteriole blood flow, increase blood vessel antihypertensive relaxation, and reduce the effect of excessive vasodilation

Inactive Publication Date: 2021-04-16
姜维
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, since the traditional Chinese medicine involved in this prescription not only contains more volatile components, but also includes some alkaloids, phenolic acids, polysaccharides and other components, the dissolution and extraction rates of each component vary greatly in conventional decoction extraction or preparation methods. Conventional extraction will cause a great loss of the active ingredients of the drug, which will seriously affect the efficacy of the drug, so it must be prepared under specific extraction conditions or equipment to ensure the stability of the drug effect

Method used

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  • Traditional Chinese medicine formula for antagonizing cerebral vascular hyperdilatation and preparation method
  • Traditional Chinese medicine formula for antagonizing cerebral vascular hyperdilatation and preparation method
  • Traditional Chinese medicine formula for antagonizing cerebral vascular hyperdilatation and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A traditional Chinese medicine prescription for antagonizing the excessive expansion of cerebral blood vessels, which is made of the following raw materials in parts by weight: 1-35 parts of Jiangxiang, 1-35 parts of Curcuma, 1-35 parts of Chuanxiong, 1-35 parts of Shichangpu, Fragrance 1-35 parts, Danshen 1-35 parts.

[0042]The present invention has the effects of promoting qi and resuscitation, promoting blood circulation and relieving pain, dispelling blood stasis and detumescence. Among them, Jiangxiang dissipates blood stasis to stop bleeding, regulates qi and relieves pain, and is used for various bleeding syndromes and blood stasis pain; turmeric, bitter cold and pungent powder, has the effects of promoting blood circulation and relieving pain, promoting qi and relieving depression, clearing heart and cooling blood; Chuanxiong is warm and dry in nature, good at walking , has the function of promoting blood circulation and promoting qi, dispelling wind and reliev...

experiment example 1

[0044] Embodiment Chinese medicine group resists nitroglycerin dilation blood vessel experiment, prepares the extract of Chinese medicine group 1g=1mL, experimental SD rat is divided into groups according to control group, extract solution low, medium and high dose, the prophylactic administration of Chinese medicine group extract for a week, In vivo blood vessel tension and blood flow experiment: Anesthetized with pentobarbital sodium, the experimental rats were anesthetized stably, the scalp was cut longitudinally 3 to 5 cm, the fascia was cut off to expose the skull, the bleeding was stopped and washed with normal saline. Nitroglycerin injection 14 mg / kg was subcutaneously injected into the side shoulder, and laser Doppler flowmeter was used to measure the cerebral hemorrhage of the model rats at 2 hours, and the blood flow rate was recorded to investigate the effect of Chinese medicine group intervening in nitroglycerin to dilate blood vessels.

[0045] The rats in each gro...

experiment example 2

[0051] This experimental example anti-beta estradiol (beta-E), epoprostenol (P-12) blood vessel dilatation experiment: according to control group, traditional Chinese medicine group, the dose of extract 10g / kg preventive administration for one week to experimental SD rats, Adopt experimental rats to make arterial rings, and rats are anesthetized by intraperitoneal injection of 2% pentobarbital sodium (2mg / kg). Under a microdissecting microscope, the brain basement membrane artery with a diameter of 0.3 mm to 0.7 mm was removed, and the perivascular tissue was removed, and the arterial blood vessel ring was cut into a ring with a length of about 3 mm. There is a 4mL Krebs liquid constant temperature bath, and the other end is hung on the electrode of the tension transducer, and the mixed gas of 95% O2-5% CO2 is continuously passed through. Gradually load the basilar membrane artery ring with a basic tension of 3mN within 30 minutes. After balancing for 1 hour, use U46619 soluti...

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Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine formula for antagonizing cerebral vascular excessive dilatation and a preparation method thereof.The traditional Chinese medicine formula is composed of 1-35 parts of lignum dalbergiae odoriferae, 1-35 parts of radix curcumae, 1-35 parts of rhizoma chuanxiong, 1-35 parts of rhizoma acori graminei, 1-35 parts of radix aucklandiae and 1-35 parts of radix salviae miltiorrhizae. The formula is used for antagonizing cerebrovascular dilatation caused by various pathological factors, inhibiting loss of vascular smooth muscle and reducing dilatation exudation and hemorrhage, so that perivascular tissue edema is inhibited, oppression pain caused by vascular dilatation is relieved, and general families can prepare the traditional Chinese medicine by themselves through the provided preparation method and equipment.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine prescription and a preparation method for antagonizing excessive expansion of cerebral blood vessels. Background technique [0002] Cerebral vascular overdilation refers to the state of relaxation and relaxation of human cerebral blood vessels beyond the normal due to special physiological or pathological factors. Under normal conditions, the vascular structure has strong elasticity and toughness. By adjusting the tension of cerebral vascular smooth muscle, the body can regulate cerebral blood flow and maintain normal blood supply. It is also a reflection of the state of blood vessels and the basic functions of the endothelium. When special physiological factors such as a sharp increase in estrogen levels during menstruation, or pathological factors such as inflammation, angiogenesis, or migraine attacks, vascular smooth muscle...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P9/00A61P7/10A61P29/00A61J3/00B02C18/10
Inventor 姜维贾璞胡娜苗莉
Owner 姜维
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