The invention relates to a prescription of qirong runchang oral liquid and a preparation method thereof. The prescription comprises astragalus root, Cistanche salsa, atractylis ovata, radix pseudostellariae, rehmanniae,figwort, ophiopogon root, angelica, sealwort, mulberry, niger seed, fructus cannabis, brush-cherry seed, bitter orange (bran frying) and honey. The preparation method comprises the following steps of: heating the honey to 116 to 120 DEG C, filtering the honey into the refined honey after boiling, grinding the radix pseudostellariae into the coarse powder, using 60% ethanol for heating reflux to extract for twice with one hour for each time, mixing the extracting solution, filtering, recovering the ethanol from the filtered solution, condensing the ethanol into clear paste with the relative density of 1.02-1.05(50 DEG C), adding water to the dregs of a decoction and the residual medicaments and decocting for twice with two hours for the first time and 1.5 hours for the second time, mixing the decocted solution, filtering, condensing the filtered solution into clear paste with the relative density of 1.10-1.20(50 DEG C), mixing the clear paste with the former one, adding the refined honey, stirring, adjusting the total amount to 1000 ml, stirring, filtering, embedding and sterilizing. The qirong runchang oral liquid can be used for supplementing qi, nourishing yin, invigorating the spleen, nourishing the kidney and relaxing the bowels and can be used for improving debilitation constipation caused by deficiency of both yin and yang, lienorenal deficiency and moist deficiency of large intestines.