1030results about How to "Good curative effect" patented technology

The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcgammaRIIIA and/or FcgammaRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcgammaR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.

According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and/or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and/or vagal nerve stimulation therapy or the like.

We disclose a colorless composition comprising silver particles and water, wherein said particles comprise an interior of elemental silver and an exterior of ionic silver oxide, wherein the silver particles are present in the water at a level of about 5-40 ppm, and wherein the composition manifests significant antimicrobial properties. Methods of use of the composition are described. The composition can be incorporated into a hydrogel with essentially no loss of antimicrobial properties.

A membrane supported biofilm reactor uses modules having fine, hollow fibres, for example, made from dense wall Poly methylpentene (PMP) used in tows or formed into a fabric. In one module, one or more sheets of the fabric are potted into a module to enable oxygen containing gas to be supplied to the lumens of the hollow fibres. Various reactors and processes, for example to treat wastewater, using such modules are described. Mechanical, chemical and biological methods are used to control the thickness of the biofilm.

The present invention relates to Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and to methods of using such polypeptides for treating or preventing cancer and other diseases. The Fc region-containing polypeptides of the present invention are preferably immunoglobulins (e.g., antibodies), in which the Fc region comprises at least one amino acid substitution relative to the corresponding amino acid sequence of a wild type Fc region, and which is sufficient to attenuate post-translational fucosylation and mediate improved binding to an activating Fc receptor and reduced binding to an inhibitory Fc receptor. The methods of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where either an enhanced efficacy of effector cell function mediated by FcγR is desired (e.g., cancer, infectious disease) or an inhibited effector cell response mediated by FcγR is desired (e.g., inflammation, autoimmune disease).

A catheter system for delivering ultrasonic energy and a therapeutic compound to a treatment site within a patient's vasculature comprises a tubular body having an energy delivery section. The catheter system further comprises a fluid delivery lumen extending at least partially through the tubular body. The catheter system further comprises a semi-permeable membrane positioned along a portion of the fluid delivery lumen. The membrane has an increased porosity when exposed to ultrasonic energy. The catheter system further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions. Each flattened region has a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The inner core further comprises wiring such that a voltage can be applied from the elongate electrical conductor across the first and second ultrasound radiating members allowing the first and second ultrasound radiating members to be driven simultaneously.

A catheter system is described for performing protected angioplasty and stenting of a patient's carotid bifurcation. A self-expanding stent is deployed across a stenosis in the patient's carotid artery. A catheter system that includes a rapid exchange angioplasty catheter with an occlusion balloon catheter positioned through the guidewire lumen is advanced through the guiding catheter to the distal end of the stent. A releasable linking device holds the catheter system together as a unit. The occlusion balloon is inflated within the stent to occlude the carotid artery and to prevent any embolic debris from traveling downstream from the treatment site. The angioplasty balloon is inflated to dilate the stenosis and to complete the expansion of the stent. The angioplasty catheter is withdrawn and any potential embolic debris is aspirated out through the lumen of the guiding catheter. The occlusion balloon is deflated and the catheter system is withdrawn.

The invention relates to the compounds and methods for inhibiting the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to compounds and methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases.

Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to, inter alia, the CNS applied via intranasal administration while reducing non-target exposure are provided. In certain embodiments, at least one vasoconstrictor is provided intranasally prior to intranasal administration of at least one therapeutic compound. In other embodiments, the vasoconstrictor(s) and therapeutic compound(s) are combined in a pharmaceutical composition and delivered intranasally. The present invention substantially increases targeting of the therapeutic compound(s) to, inter alia, the CNS while substantially reducing unwanted and potentially harmful systemic exposure. The preferred administration of the invention applies the vasoconstrictor(s) and/or therapeutic compound(s) to the upper third of the nasal cavity, though application to the lower two-thirds of the nasal cavity is also within the scope of the invention.

A disposable insect and/or arthropod trapping device that generates its own attractants of carbon dioxide (CO₂), lactic acid and/or ammonia through the chemical reaction of adding a weakly acidic liquid such as vinegar (acetic acid) to solids such as baking soda (sodium bicarbonate), with the optional addition or substitution of urea and/or lactic acid. The liquids are mixed over a period of hours or days onto the solids to generate CO₂ in the vicinity of an insect/arthropod trap having an insect-debilitating surface that traps the insects and arthropods when they alight on the surface. The container may have a cylindrical shape with an upper and lower chamber with fly paper attached to the container. The fly paper may be secured to the base and/or top portions of the container, or there may be fly paper like appendages to trap insects attracted by emitted gases.

The invention relates to immunotherapeutic compounds, compositions that include such compounds, and methods of using the compounds, for example, to treat an individual having, at risk for, or previously treated for a cancer.

This invention relates to a use of IL-22 in the treatment of viral hepatitis. As illustrated in the examples of this invention, IL-22 can significantly reduce liver damage caused by hepatitis virus, and can significantly reduce the increase of transaminase ALT/AST induced by hepatitis virus. In addition, the IL-22 dimer of this invention can effectively treat viral hepatitis.

The present invention is drawn to systems and methods for treating warts. The system can comprise a wart treatment formulation comprising a substance for treating warts and a cavity patch comprising an open cavity being configured to become a closed cavity upon application and adherence to a skin surface. The closed cavity can be configured to contain the wart treatment formulation.

The invention provides marine biomaterial composite hydrogel dressing and a preparation method thereof and relates to the technical field of medical dressing. The hydrogel dressing is prepared from asodium alginate-fish collagen mixed solution and a chitosan-crosslinking agent mixed solution, wherein the sodium alginate-fish collagen mixed solution is prepared from sodium alginate, fish collagen,polyvinyl alcohol, sodium carboxymethyl cellulose, pectin, glycerin, propanediol and distilled water; the chitosan-crosslinking agent mixed solution is prepared from chitosan, a crosslinking agent, glacial acetic acid and distilled water. The invention also provides the preparation method of the dressing. The sodium alginate-fish collagen mixed solution is cultured at the constant temperature, the chitosan-crosslinking agent mixed solution is added, the mixture reacts, and the hydrogel dressing is obtained. The hydrogel dressing has excellent mechanical property, moisture retention and biocompatibility, accelerates wound repairing, can diminish inflammation and perform sterilization, has no wound inflammation reaction, effectively promotes wound healing, is easy to remove and does not stick to a wound surface.

The invention relates to a traditional Chinese medicine preparation for treating herpes simplex keratitis. The traditional Chinese medicine preparation is prepared from the following raw pharmaceutical materials in parts by weight: 18-22 parts of honeysuckle flower, 18-22 parts of radix isatidis, 18-22 parts of dandelion, 18-22 parts of hooked uncaria, 13-17 parts of red peony root, 13-17 parts of selfheal spike, 13-17 parts of folium isatidis, 8-12 parts of forsythia fruit, 8-12 parts of herba schizonepetae, 8-12 parts of ledebouriella root, 8-12 parts of scutellaria root, 8-12 parts of balloon flower root, 8-12 parts of bupleurum root, 8-12 parts of cicada slough, 8-12 parts of chrysanthemum flower, 3-7 parts of peppermint and 3-7 parts of licorice root. The traditional Chinese medicine preparation has the advantages of good treatment effect, high effect taking speed, no toxic and side effects and low recurrence rate.

The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.

The current invention relates to a process for increasing the efficacy of cancerous disease inhibiting therapeutic agents delivered to a treatment region of a tissue structure, such as a tumor. The multi-step procedure takes advantage of the resulting thermal stress response occurring as a result of exposure to the cold. Coordinating the thermal related stress response with the timing of cancerous disease inhibiting agent action provides a unique therapeutic regiment to treat tumors which provides a maximized effect on the tumor, protects normal cells, and activates local pro-inflammatory cells.

The invention discloses a Chinese medicinal composition for treating arthritis, osteoproliferation and disc protrusion, which comprises the following raw material constituents (by weight ratio): large-leaf gentian root, ledebouriella root, Ligusticum wallichii, Clematis chinensis, achyranthes and cyathula root, root of herbaceous peony, prepared rehmannia root, Chinese angelica root, eucommia bark, Cinnamomum cassia, wolferry fruit, morinda root, dipsacus root, poria cocos, Chinese ephedra, Loranthus mulberry mistletoe, cassia twig, corydalis tuber, notoginseng, notopterygium root, root of red rooted saliva, tetrandra root, spatholobus stem, dried orange peel, licorice root, pangolin scales, buthus martensi karsch, earthworm, wood louse, dragon's blood resin, wasp's nest and drynaria.

The invention relates to a cytomedicine for preventing intrauterine adhesion and repairing endometrium injury, and a preparation method thereof. The cytomedicine consists of umbilical cord or placenta mesenchymal stem cells, recombinant human stromal cell-derived factor-1alpha (rhSDF-1alpha), and sodium hyaluronate gel which is used for bearing the umbilical cord or placenta mesenchymal stem cells and the rhSDF-1alpha and has sustained-release and anti-inflammatory effects. When the cytomedicine is injected into a uterine cavity, the curative effects of promoting stem cells and uterus tissue cells to migrate to the injured part, reducing intimal tissue fibrosis, promoting endometrial regeneration and repair, physically obstructing and preventing intrauterine adhesion and the like are achieved. The problems that the stem cells are singly applied to be difficult in local position as well as the traditional intrauterine adhesion and endometrium injury repair method cannot realize serious endometrium injury repair or is short in action time and poor in local curative effect are solved. The preparation provided by the invention is simple in preparation method, easy to implement, safe and effective, and can doubly improve the concentration of the stem cells in the injured part, prolong the action time of the stem cells and improve local curative effect.

The present invention provides systems and methods of managing delivery of an orthodontic treatment plan using treatment guidelines, instructions and appointment planning tools customized to the individual patient being treated. A method includes, e.g., generating a treatment plan for a patient, generating a customized set of treatment guidelines, providing the set of customized treatment guidelines to the practitioner; and providing a set of orthodontic appliances to the practitioner.

The invention discloses fire-clearing health-care tea. The fire-clearing health-care tea is prepared from the following raw materials in part by weight: 60 to 100g of siraitia grosvenorii, 60 to 90 parts of chrysanthemum, 20 to 50 parts of dwarf lilyturf tuber, 20 to 50 parts of tangerine peel, 10 to 30 parts of hawthorn, 15 to 40 parts of weeping forsythia, 5 to 20 parts of silktree albizzia bark, 10 to 30 parts of anemarrhena asphodeloides, 20 to 40 parts of phellodendron, 5 to 20 parts of tree peony bark, 20 to 40 parts of dandelion, 10 to 25 parts of mongolian snakegourd root, 5 to 20 parts of rehmannia root, 10 to 30 parts of calamintha chinensis benth, 10 to 25 parts of philippine violet herb, 5 to 20 parts of seed of feather cockscomb, 5 to 20 parts of buerger pipewort flower, 10 to 30 parts of cyrtomium fortunei and 40 to 60 parts of crystal sugar. The fire-clearing health-care tea has good effects of clearing pharynx, benefiting throat, clearing internal heat, reducing inflammation and relieving summer heat, and has good adjuvant therapy effects on symptoms of excessive internal heat such as dry throat, hoarseness, gingival swelling, oral erosion, red and swollen heat pain, bitter taste in mouth, thirst, cough and the like and diseases caused by the symptoms such as common cold, pharyngitis, gingivitis and the like.

An air cleaning apparatus comprising at least one UV light source and at least one target structure comprising a plurality of elongated tubular elements, whereby air cleaned by the UV light source in the presence of the target structure creates a zone of plasma including advanced oxidation products. The target structure incorporates at least one selected from the group consisting of titanium dioxide, copper, silver, and rhodium. The plurality of tubular elements is arranged in one or more matrices of elongated tubular elements. The matrices are optimized to allow air to flow through the elongated elements. The matrices comprise two parallel wall-shaped structures of stacked tubular elements, and the UV light source is located between two wall-shaped structures, whereby air flows through the tubular elements. A frame and an insulating UV light transparent cover generally surrounding the UV light source may be provided.

The invention relates to a prescription of qirong runchang oral liquid and a preparation method thereof. The prescription comprises astragalus root, Cistanche salsa, atractylis ovata, radix pseudostellariae, rehmanniae,figwort, ophiopogon root, angelica, sealwort, mulberry, niger seed, fructus cannabis, brush-cherry seed, bitter orange (bran frying) and honey. The preparation method comprises the following steps of: heating the honey to 116 to 120 DEG C, filtering the honey into the refined honey after boiling, grinding the radix pseudostellariae into the coarse powder, using 60% ethanol for heating reflux to extract for twice with one hour for each time, mixing the extracting solution, filtering, recovering the ethanol from the filtered solution, condensing the ethanol into clear paste with the relative density of 1.02-1.05(50 DEG C), adding water to the dregs of a decoction and the residual medicaments and decocting for twice with two hours for the first time and 1.5 hours for the second time, mixing the decocted solution, filtering, condensing the filtered solution into clear paste with the relative density of 1.10-1.20(50 DEG C), mixing the clear paste with the former one, adding the refined honey, stirring, adjusting the total amount to 1000 ml, stirring, filtering, embedding and sterilizing. The qirong runchang oral liquid can be used for supplementing qi, nourishing yin, invigorating the spleen, nourishing the kidney and relaxing the bowels and can be used for improving debilitation constipation caused by deficiency of both yin and yang, lienorenal deficiency and moist deficiency of large intestines.

The compound Huangdai tablet as a kind of Chinese medicine preparation for treating acute leukemia, chronic granulocyte leukemia, authentic erythrocytosis, etc. is prepared with realgar 12-18 wt%, natural indigo 25-42 wt%, red sage 36-46 wt% and pseudostellaria root 12-18 wt%. The preparation process includes grinding realgar, natural indigo and pseudostellaria root into fine powder, mixing the fine powder; decocting red sage for 3-5 times, filtering, merging the filtrate, and concentrating at 48-54 deg.c to form extractum of 1.25-1.55 density; adding the red sage extractum into the fine mixed powder, pelletizing, drying, adding magnesium stearate in 1 % to mix homogeneously; pelletizing and tabletting to form 0.25-0.30 g tablet and coating.

The disclosed preparation is prepared from dipsacus root, notoginseng, prepared rhizome of rehmannia, drynaria, native copper, frankincense, Chinese angelica root, Ligusticum wallichii, root of herbaceous peony, cortex acanthopanacis, myrrh, rhubarb horsetails, dragon's blood resin, radix paeoniae rubrathe, safflower, borax through pre-processing, weighing, mixing and disintegrating, grinding to obtain the synthesized medicinal powder.

Systems, devices and methods for altering sensory perceptions are disclosed. The systems and methods of the present invention comprise operably coupling at least one device for capturing sensory data to a computing device, identifying the captured data, querying at least one data base to identify desired behaviors and/or outcomes, querying the same data base or other data bases to identify and/or calculate modified, enhanced and/or virtual sensory data likely to achieve the desired behaviors or outcomes, generating modified, enhanced and/or virtual sensory data, and substituting the altered sensory data in real or near real time for the sensory data. The present invention advantageously alters sensory perceptions to promote health, ease patient's fears and allow safe performance of medical procedures, promote personal and public safety, and improve the success of military mission and operations.

A facial paralysis objective evaluation method and system thereof, characterized in that the method comprises the following steps: collecting facial images of patients with facial paralysis through an image acquisition device 1; obtaining facial feature point detection models, and detecting The facial feature points in the facial image are extracted; the facial symmetry feature is extracted according to the detected facial feature points; the facial paralysis grading classifier is obtained, and the facial paralysis grading classifier automatically determines the facial palsy grading evaluation result of the facial paralysis patient according to the facial symmetry feature. The present invention quantifies the facial structure symmetry with the facial symmetry feature, and automatically obtains the facial paralysis grading evaluation result by calculating the facial symmetry feature, thereby eliminating subjective deviation, and can be used to assist clinicians to accurately and quickly obtain the facial paralysis grading evaluation result, Establish a suitable treatment plan for patients with facial paralysis to improve the curative effect of rehabilitation.

The invention provides a medicament composition for treating pulmonary fibrosis. The medicament composition comprises the following active pharmaceutical ingredients by weight: 5-15 parts of ginseng, 5-15 parts of danshen root, 1-11 parts of angelica, 5-15 parts of manyflower solomonseal rhizome, 5-15 parts of perilla frutescens, 1-11 parts of brassica alba boiss, 1-11 parts of fructus aurantii immaturus and 5-15 parts of Japanese ardisia herb. The invention also provides a preparation method of the composition and application of the composition to preparing the medicaments for treating pulmonary fibrosis. The chemical fiber No.1 medicament composition provided by the invention has the effect of inhibiting proliferation of human embryo lung diploid fibroblasts (2BS), can be used for preparing the medicaments for treating pulmonary fibrosis, has obvious clinical effect, minimal side effect and good safety and provides a new choice for clinically treating pulmonary fibrosis.

A mould for horizontal casting of molten metal comprising a mould body forming an open-ended mould cavity having an inlet end and an outlet end. An annular permeable wall member is mounted in the mould body adjacent the inlet end of the mould cavity with an inner face thereof forming an interior face of the mould. A refractory transition plate is mounted at the inlet end of the mould cavity, this transition plate providing a mould inlet opening having a cross-section less than that of the mould cavity. This provides an annular shoulder at the inlet end of the cavity. Means are provided for feeding molten aluminum through the inlet opening. Separate conduits are also provided for feeding a gas into the shoulder and via the permeable wall means for providing a layer of gas between the metal and the inner face of the mould. A gas that is more reactive with molten aluminum is fed into the shoulder and a less reactive gas is fed via the permeable wall. The reactions with the molten aluminum create a skin or shell on the aluminum which provides smooth passage through the mould and allows for more rapid secondary cooling of the emerging ingot.