171results about How to "Good curative effect" patented technology

The invention discloses a multi-source collaborative dynamic time sequence TCP prediction method and system, a medium and a program product, and the method comprises the steps: collecting multi-source heterogeneous data, including DVH data, CT data, CPP data and longitudinal follow-up data of a plurality of time nodes, of a patient in a whole radiotherapy period; performing hierarchical preprocessing and data format unification on the multi-source heterogeneous data; constructing a dynamic time sequence feature fusion matrix containing a time dependency relationship; constructing a deep learning model integrating a time sequence processing unit and a cross-modal fusion unit, wherein the model supports an incremental learning iteration updating mechanism; using the model to output TCP prediction results of a new patient at different time nodes; and if the new patient is a special case, calling the clinical rule adaptation model, and correcting the TCP prediction result by adopting a mixed correction strategy combining rule matching and doctor experience weight. According to the method, multi-source heterogeneous data can be deeply fused, time dynamic association is captured, modal feature contribution degree is quantified, continuous iterative updating is supported, and individual differences are adapted.

The invention belongs to the technical field of ecological water, mainly relates to ecological water for removing fruit peculiar smell, and particularly relates to ecological water for removing fruit peculiar smell and a preparation method thereof. Neotame and glucose modified cortex phellodendri are matched with tupistra chinensis, pogostemon cablin, liquorice and clove to be decocted into a traditional Chinese medicine decoction. According to the invention, lactobacillus plantarum ATCC 8014 and bacillus subtilis ATCC 6633 are used for fermentation. The antibacterial activity of the ecological water is improved, and the bitter taste of the cortex phellodendri is effectively removed due to the synergism of the two sweetening agents, namely the neotame and the glucose. The bacillus subtilis HZ-72 antagonistic bacteria used in the invention can enhance the capability of inhibiting pathogenic bacteria. Syzygium aromaticum has antibacterial activity, pogostemon cablin has an antiviral effect, and the syzygium aromaticum and the pogostemon cablin cooperate to enhance the antibacterial The ecological water prepared by the invention can remove peculiar smell and preserve freshness, and has a great development prospect in the field of fruit preservation.

Unsaturated carbon-carbon double bonds are introduced into a molecular main chain of polysaccharide, then the polysaccharide reacts with alkyl iso (thio) cyanate, and then a photoinitiator and a cross-linking agent are added, so that the anti-adhesion photocuring medical adhesive is obtained. The invention also discloses a preparation method. The anti-adhesion photo-curing medical adhesive provided by the invention can be applied to a target region in an operation, and can be quickly cured in a photo-induction manner, so that the treatment purposes of local filling, blocking, anti-adhesion and the like are achieved. The anti-adhesion film can be efficiently and conveniently used for postoperative tissue and organ anti-adhesion, the curative effect can be improved, and the risk of postoperative adhesion related complications is reduced.

The application belongs to the technical field of biological medicine, and discloses an in-situ vaccine type mRNA-tLNP preparation for solid tumor treatment and preparation and application thereof. The preparation is designed by double targets, so that CAR-T kills more tumor cells to overcome tumor heterogeneity, changes the tumor immune microenvironment through autocrine fusion proteins (anti-PD-1 scFv and TGFbetaRII, IL-15 and Flt3L, CD40L), promotes T cell proliferation, and recruits and activates dendritic cells, cross-presents new antigens in the tumor local part, and produces in-situ vaccination effects; circular RNA encoding the above proteins is prepared, and the circular RNA is wrapped by lipid nanoparticles modified by CD3 antibodies, so as to be directly delivered to the body, and a significant solid tumor treatment effect is produced.

The invention relates to the technical field of medical instruments, and particularly discloses a multifunctional medical physiotherapy robot which comprises a cabinet, an operation screen and a six-axis robot, and a quick-change base is mounted on an output shaft of the six-axis robot. The core is that the quick-change base can be quickly detached and provided with four functional modules, namely a low-frequency pulse spray massage head, a radio frequency thermal therapy massage head, a shock wave massage head and a negative pressure massage head. Each massage head is connected with the execution end through a structure comprising a flexible connecting piece so as to adapt to the curved surface of the human body and compensate motion errors. Through the quick change mechanism and the central control system, integration and programmed collaborative application of multiple advanced physiotherapy technologies on one device are achieved, the problems that an existing device is single in function and poor in collaboration are solved, and the device has the advantages of being accurate in treatment, convenient and fast to operate and wide in adaptation disease range.

The utility model relates to moxa -burning technical field. A kind of multi-position combined moxa -burning moxa -burning chair, including a seat base, seat base includes seat plate and chair back, chair back includes a rear end opening hollow fixed back plate and the movable back plate for closing the rear end opening of hollow fixed back plate, movable back plate and hollow fixed back plate longitudinal sliding connection;At least three first installation holes from top to bottom are set in hollow fixed back plate, and first installation hole is equipped with first partition moxa -burning device;The seat plate is slidably connected with an abdominal moxa -burning plate in front-rear direction, and the abdominal moxa -burning plate includes sequentially connected push-pull plate and moxa -burning support plate, and at least three second installation holes from top to bottom are set in moxa -burning support plate, and second installation hole is equipped with second partition moxa -burning device.The utility model has realized the problem that clinical moxa -burning operation cannot simultaneously consider back and abdomen due to body position restriction.

The invention belongs to the technical field of medical instruments, and particularly relates to an invisible anterior tooth adduction correction device based on implant anchorage, which comprises a main body, two sides of the main body are fixedly connected with a pair of anchorage arms, one end, far away from the main body, of each anchorage arm is fixedly connected with a mounting part, and the edge of the main body is fixedly connected with a pair of fixing rings. The fixing ring is located between the pair of anchorage arms, a sliding groove is formed in the edge of the side, away from the fixing ring, of the body, a pair of sliding blocks are slidably connected to the inner side of the sliding groove, first hooks are fixedly connected to the sides, away from the fixing ring, of the sliding blocks, and a pair of second hooks are arranged on the two sides of the sliding groove. The anterior tooth adduction device has the beneficial effects that by arranging the main body, the anchorage arm, the anchorage nail and the fixing ring, the anterior tooth adduction device can be fixedly mounted in the palate skull of the oral cavity of a patient, and anchorage is provided for anterior tooth adduction of the patient, so that loss of anchorage is avoided, and accurate control on the anterior tooth adduction speed, direction and mode of the patient is realized.

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound preparation for treating diabetic peripheral neuropathy, which comprises the exclusive active enrichment part of eight kinds of traditional Chinese medicines such as Astragalus, Radix Rehmanniae, and Caulis Sargentodoxae, and is combined with pharmaceutical excipients. The preparation establishes the therapeutic principle of tonifying qi and nourishing yin, removing blood stasis and dredging collaterals, tonifying kidney and protecting marrow, and directly attacks the core pathogenesis of the disease. The effective components are precisely enriched by using the processes of enzymolysis, aqueous two-phase extraction, and ultrafiltration, and the pH-dependent enteric-soluble pellet capsules are optimized to improve the bioavailability and reduce the gastrointestinal irritation. The pharmacodynamics confirms that the product can regulate glucose metabolism, resist oxidative stress, inhibit inflammation, improve nerve microcirculation, repair damaged nerve myelin sheath, significantly improve the pain threshold and nerve conduction velocity, and the curative effect is better than that of conventional Chinese and western medicines. The acute and long-term toxicity tests show that the product has high safety, the process is stable and controllable, and is suitable for industrial production, thereby providing an efficient and safe treatment option for the disease.

The invention relates to the technical field of biological medicine, and particularly discloses application of combination of an IGF1R inhibitor and immunotherapy in preparation of a medicine for treating lung cancer, the combination of the IGF1R inhibitor OSI-906 and an immune checkpoint inhibitor can effectively enhance the curative effect of small cell lung cancer immunotherapy, and compared with treatment with a single immune checkpoint inhibitor or the IGF1R inhibitor, the curative effect of the IGF1R inhibitor OSI-906 and the curative effect of the IGF1R inhibitor OSI-906 can be effectively enhanced. The IGF1R inhibitor combined with the immune checkpoint inhibitor can remarkably inhibit the growth level of tumors, the growth level of the tumors is obviously lower than that of the single use of common antibody drugs, because the IGF1R inhibitor can reduce the activity of endothelial cell IGF1 / IGF1R pathways and destroy the vascular structure of small cell lung cancer, the combined immunotherapy of the IGF1R inhibitor can remarkably enhance T cell infiltrating tumors, and the immune checkpoint inhibitor can effectively inhibit the tumor growth. Therefore, growth of small cell lung cancer cells is inhibited, the tumor immunotherapy effect of the immune checkpoint inhibitor is improved, and tumor growth is better inhibited.

The invention relates to the technical field of skin care, and discloses a sustained-release composition containing azelaic acid composite lipidosome and application of the sustained-release composition in acne treatment and skin repair. Comprising a composite liposome, an encapsulated active component and a dispersion medium, the composite liposome is composed of a lipid bilayer, the lipid bilayer comprises phospholipid, cholesterol and pegylated phospholipid, and the phospholipid is a mixture of hydrogenated soybean phospholipid and dipalmitoyl phosphatidylcholine; the encapsulated active component comprises a fat-soluble component and a water-soluble component; the water-soluble components comprise a hamamelis virginiana leaf water extract and a herba portulacae extract; the dispersion medium is a phosphate buffer solution; by optimizing lipid composition, introducing surface modification and constructing a multi-layer release system, the invention aims to synergistically exert multiple effects of antibiosis, anti-inflammation, cutin regulation, red fading, repair and the like, and provides an efficient, mild and integrated solution for acne and sequelae skin problems thereof.

The invention belongs to the technical field of microorganisms, and particularly relates to application of bifidobacterium animalis subsp. Lactis in improvement of osteoporosis. The bifidobacterium animalis subsp. Lactis BL-136 provided by the invention is preserved in Guangdong Microbial Culture Collection Center, the preservation number is GDMCC No: 67831, and verification proves that the strain has excellent capability of inhibiting osteoclast differentiation and has obvious application advantages in the aspect of relieving osteoporosis. The microgel preparation prepared from the strain can play an excellent role in relieving the osteoporosis, and the curative effect on the osteoporosis is remarkably improved. Therefore, the invention proves the curative effect of the bifidobacterium animalis subsp. Lactis BL-136 and the microgel preparation thereof in the aspect of relieving the osteoporosis, and scientific thinking and technical support can be provided for the development of medicines for treating the osteoporosis.

Provided is an antibody drug conjugate, specifically comprising a therapeutic antibody moiety, an intermediate linker moiety and a cytotoxic drug moiety which are linked. The therapeutic antibody moiety is an antibody against an HER2 target. The cytotoxic drug moiety is a camptothecin topoisomerase I inhibitor. The cytotoxic drug moiety or the linker-cytotoxic drug moiety is modified by means of deuterium substitution. The antibody drug conjugate can be used for the prevention or treatment of cancers.

The utility model relates to the technical field of heating pads, and discloses a massage heating pad which comprises a frame, a shell is fixedly connected to one side of the frame, two massage modules distributed in a mirror image mode are fixedly connected to the interior of the shell, and an inner layer liner, a heating layer and an outer layer liner are fixedly connected to the interior of the frame. And a plurality of electrode plates which are arranged in a rectangular array are fixedly connected to one side of the outer-layer liner. According to the massage heating pad, two therapies of massage and electrical stimulation are combined, the massage module acts on muscular tissue in a mechanical mode, blood circulation is promoted, muscular tension is relieved, weak current emitted by the electrode plates can directly stimulate acupuncture points of the human body, meridians and collaterals are further promoted to be smooth, and the effects of relieving pain and relaxing the mind and body are achieved; the dual therapies complement each other, the curative effect can be remarkably improved, and due to the fact that the electrode plates are arranged in a rectangular array mode, accurate stimulation can be conducted on different acupuncture points or pain areas.

Provided are a compound used as a BCR-ABL inhibitor, namely a compound of formula (I), or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition comprising the compound. Moreover, the present invention relates to a use of the compound in the preparation of a drug for treating BCR-ABL related diseases.

This invention discloses a load 32 The preparation method of the ultrathin sheet-like chitosan hydrogel applicator of P includes: (1) preparing a chitosan aqueous solution; (2) adding methacrylic anhydride to the chitosan aqueous solution to obtain methacrylated chitosan; (3) preparing a methacrylated chitosan aqueous solution; (4) adding 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylphenylacetone to the methacrylated chitosan aqueous solution to obtain a chitosan hydrogel precursor solution; (5) coating the inner wall of a polytetrafluoroethylene mold with a superhydrophilic coating; (6) adding Na2H 32 PO4 aqueous solution and chitosan hydrogel precursor solution are added to the mold, stirred and then cured by light; (7) the cured hydrogel is taken out and sealed between two layers of transparent tape. This application can prepare an ultra-thin hydrogel applicator, thereby reducing the obstruction of radiation by the hydrogel material itself and enhancing the therapeutic effect of the applicator.

This invention belongs to the field of biomedicine, specifically relating to siRNA that inhibits AR gene expression, comprising a sense strand and an antisense strand, wherein the sense strand and the antisense strand are at least partially anticomplementary to form a double-stranded region, and the sense strand or antisense strand consists of 19-25 nucleotides with blunt ends of complementary nucleotide sequences; or the antisense strand consists of 27 nucleotide sequences with overhangs. The siRNA of this invention can maintain long-term efficacy with a single dose, exhibiting good compliance in patients with chronic diseases such as androgenetic alopecia. Furthermore, it has lower off-target toxicity and fewer side effects compared to small molecule chemical drugs and hormone drugs.

The invention discloses an application of 2, 3-diphosphoglycerate dependent phosphoglycerate mutase (2, 3-BdpM) or a biological material related to the 2, 3-diphosphoglycerate dependent phosphoglycerate mutase (2, 3-BdpM) in preparation of a medicine for treating gastric cancer. The 2, 3-BdpM can be used as a novel activating factor of FPR1 (Formyl Peptide Receptor 1), and is used for specifically inducing macrophages to be polarized to a pro-inflammatory anti-tumor phenotype, so that the tumor microenvironment of gastric cancer is remodeled. When the 2, 3-BdpM is combined with an immune checkpoint inhibitor for use, the immunotherapy curative effect of the gastric cancer can be remarkably enhanced, the CD8 + T cell infiltration and cytotoxicity level can be improved, and meanwhile, obvious systemic toxicity is not caused. The invention further provides a gastric cancer immunotherapy composition containing the 2, 3-BdpM and application of the gastric cancer immunotherapy composition in enhancing the anti-gastric cancer effect of CAR macrophages, and the 2, 3-BdpM has good safety and clinical transformation prospects.

The invention belongs to the technical field of medicines, and particularly relates to a probiotic-fermented medicinal and edible traditional Chinese medicine composition as well as a preparation method and application thereof. Specifically, the medicinal and edible traditional Chinese medicine composition comprises the following components: Chinese yam, lotus seed, white hyacinth bean, fingered citron, dandelion, coix seed, Chinese date, malt and liquorice. According to the invention, the medicinal and edible traditional Chinese medicine raw materials are crushed, and the probiotics are added for fermentation treatment, so that the medicinal and edible traditional Chinese medicine composition based on probiotic fermentation is obtained, and the composition has a good curative effect on chronic diseases such as gastrointestinal diseases and the like, thereby having a good practical application value.

The application discloses application of a small-molecule compound targeting TIM-3 in tumor immunotherapy and relates to the technical field of immunology and antitumor drugs. The small-molecule compounds DTS and CT are safe and verified marketed drugs, and it is found that the small-molecule compounds can bind to TIM-3 protein and regulate T cell exhaustion related to TIM-3. + Experiments prove that DTS and CT can effectively inhibit CD8 T cell exhaustion, promote expansion of exhausted precursor T cells, and comprehensively enhance T cell antitumor immune function. In a melanoma model, the compounds significantly inhibit tumor growth and reduce the proportion of tumor-infiltrating T cell exhaustion. The application uses the strategy of "new use of old drugs", provides a TIM-3 small-molecule inhibitor with high safety, oral administration, strong penetration and low cost, effectively solves the clinical transformation predicament of existing antibody drugs and newly synthesized small molecules, and provides a new scheme for rapid transformation of tumor immunotherapy.

This invention belongs to the field of medical materials, specifically relating to a patterned bio-barrier membrane with self-adhesive function and its preparation method. The preparation method includes: dissolving the adhesive matrix in a buffer solution, then adding reactive amino acids and a stabilizer to obtain a first mixture; adding ethanol and a hydrophobic agent to the first mixture, and stirring under heating conditions to obtain a second mixture; adding a thickener, a calcium supplement, and a reinforcing agent to the second mixture, continuing stirring, and then adding a protein precipitation reagent to precipitate the mixture, obtaining a hydrogel; covering a collagen membrane with a patterned porous mold, and adding the hydrogel to allow it to flow into the pores and solidify. This invention achieves precise adhesive loading through patterned design, combining advantages such as simple operation, reliable fixation, good biocompatibility, and high osteogenic efficiency, effectively solving the barrier membrane fixation problem in GBR technology, and is suitable for bone defect treatment in dental implant prosthesis restoration.

The application discloses a kind of intelligent physiotherapy control systems of physiotherapy equipment, belong to the technical field of physiotherapy instrument control system, the system includes integrated in physiotherapy comb body physiotherapy execution module, for real-time acquisition user physiological parameter physiological parameter sensing module, and with the communication connection of both intelligent control unit.State analysis module is included in intelligent control unit, for the current physiological state of user is analyzed according to the physiological parameter of acquisition;Strategy generation module is used to match or generate target physiotherapy strategy from preset physiotherapy mode library based on current physiological state;And drive control module is used to drive physiotherapy execution module to work according to target physiotherapy strategy.The application is fused by multi-source physiological signal, and the state of user is analyzed, and using the intelligent decision mechanism including reinforcement learning, generative algorithm, dynamically generates or optimizes physiotherapy strategy, realizes the real-time self-adaptation and high personalization of physiotherapy process, improves the safety and effectiveness of physiotherapy.

This invention discloses a seated rehabilitation training device, comprising a base, a seated platform mounted on the base, and a column mounted at each of the four corners of the base. Two sets of treatment components are slidably connected between adjacent columns. A top frame is mounted on the top of each column, and a traction component is mounted on the top frame. The treatment components include a mounting box, a push rod, a guide slider, and a push pillow. The traction component includes two parallel first pulleys, multiple spaced second pulleys, a traction rope, and a traction frame. An airbag device is connected to each column. This invention integrates three core rehabilitation functions—spinal traction, multi-directional mechanical compression, and airbag pressure therapy—into a single device. Patients can receive combined traction and multi-directional compression treatment sequentially or simultaneously on the same device and in the same posture, achieving synergistic therapeutic force and effectively overcoming the drawbacks of traditional therapies that require switching between different devices and fragmented treatment processes.

This invention discloses a digital therapy system for cognitive impairment based on multimodal interaction and dynamics. Through an interaction and data acquisition layer, multidimensional data is collected via gamified tasks in a gamified training environment, and preprocessed to obtain preprocessed multidimensional data. An intelligent analysis and decision-making layer is responsible for modeling, evaluating, and optimizing the preprocessed multidimensional data to generate rehabilitation strategies. An application and presentation layer provides dynamically adjusted training content, enabling objective, continuous, and fine-grained quantitative assessment of cognitive function. Based on the patient's real-time abilities and performance, truly personalized rehabilitation training content is dynamically generated and adjusted, enhancing the fun and patient participation in the training process, and improving rehabilitation efficacy and efficiency.

This invention provides a method for preparing a Lian Shen Tong Lin preparation, belonging to the field of pharmaceutical preparation technology. The preparation method involves mixing Atractylodes macrocephala, Acorus tatarinowii, and β-cyclodextrin, and then performing dynamic extraction, vacuum concentration, and centrifugal emulsification to obtain volatile oil powder. The remaining Atractylodes macrocephala and Acorus tatarinowii residue after volatile oil extraction are refluxed to obtain Atractylodes macrocephala and Acorus tatarinowii powder. Eight herbs, including Akebia trifoliata, Polygonum aviculare, Gardenia jasminoides, Rheum palmatum, Salvia miltiorrhiza, Dioscorea hypoglauca, Poria cocos, and Glycyrrhiza uralensis, are refluxed to prepare eight herbal powders. Three herbs, including Coptis chinensis, Sophora flavescens, and Dianthus superbus, are refluxed to prepare three herbal powders. Finally, the volatile oil powder, Atractylodes macrocephala and Acorus tatarinowii powder, the eight herbal powders, and the three herbal powders are mixed to obtain the Lian Shen Tong Lin powder. This invention, by simultaneously extracting and encapsulating the volatile oils from Atractylodes macrocephala and Acorus tatarinowii during the dynamic extraction process, avoids losses caused by adhesion to equipment during the extraction and separation of volatile oils, improves the utilization rate of volatile oils, and thus enhances the efficacy of the product.

The present application belongs to the technical field of traditional Chinese medicine, and specifically discloses a traditional Chinese medicine composition for treating children's functional dyspepsia, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw medicinal materials by weight: Fructus Aurantii Immaturus 5-20 parts, Magnolia officinalis 5-20 parts, Forsythia suspensa 5-30 parts, Dendrobium 5-30 parts, Atractylodes macrocephala 5-20 parts, and Glycyrrhiza 5-30 parts. The pharmacological experiment results show that the traditional Chinese medicine composition has the effects of improving gastrointestinal motility and regulating gastrointestinal hormone secretion, has a significant therapeutic effect on children's functional dyspepsia, has stable curative effect, and has a small dosage. Meanwhile, the present application has the advantages of simple process operation, low cost, good controllability and stability, and is suitable for industrialized mass production.

The application relates to a kind of SN38-fatty alcohol prodrugs and its self-assembly nanoparticles and application, belong to the field of new excipients and new dosage forms of pharmaceutical preparations, and relates to a kind of 7-ethyl-10-hydroxy camptothecin prodrug antitumor preparation, specifically to the construction of SN38-fatty alcohol prodrug and its self-assembly nanoparticles containing the prodrug, and its application as a drug delivery system in the preparation of antitumor drugs.The structure general formula (I) of SN38-fatty alcohol prodrug or its pharmaceutically acceptable salt is as follows: wherein, n, R, X are described in the claims and the specification.The SN38-fatty alcohol prodrug of the application can be self-assembled into nanoparticles, can effectively improve curative effect, reduce its toxic side effect.

This utility model relates to the field of medical comfort technology, specifically disclosing a simulated hand device for psychological comfort, including a comfort component one and a comfort component two. The comfort component one and the comfort component two are respectively fitted onto the palm area and back surface of the patient's hand, forming a symmetrical wrapping structure. A temperature control mechanism is embedded in the internal space of the comfort component one and the comfort component two. Precise temperature control: Temperature is controllable through an electric heating wire or PTC heating element to meet the personalized temperature needs of different patients. Modular design: The outer contact layer and inner sealing layer are detachable, facilitating cleaning, disinfection, and component replacement, improving hygiene. Flexible adaptability: The Velcro connecting strap and pleated structure can adapt to different hand shapes, enhancing wearing comfort. Acupoint-assisted therapy: Marked points accurately locate the Shenmen and Neiguan acupoints, enhancing the therapeutic effect of psychological comfort. Material safety: Medical-grade silicone material is non-irritating, and the textured layer simulates the feel of skin, reducing the risk of allergies.

The utility model relates to a novel calcaneus posterior articular surface fixing steel plate which comprises a plate face, a plurality of screw holes are formed in the plate face, a screw hole A, a screw hole B and a screw hole C are sequentially arranged, a screw hole F, a screw hole E and a screw hole D are sequentially arranged, the screw hole F, the screw hole E and the screw hole D are located below the screw hole A, the screw hole B and the screw hole C, and the screw hole A, the screw hole B and the screw hole C are located below the plate face. Screws penetrate through the screw holes A, the screw holes B and the screw holes C to be fixed to the sustentaculum tali, and combined raft supporting is conducted on the posterior articular surface and the sustentaculum tali. When screws of part of patients are cut out from the calcaneus sulcus, the spare screw hole F, the spare screw hole E and the spare screw hole D are used for replacing the screw hole A, the screw hole B and the screw hole C respectively, and it is guaranteed that the rear articular surface can be supported through three screws. According to the application, the comminuted calcaneus posterior articular surface can be powerfully supported, the stability of fracture fixation is powerfully guaranteed, the possibility of long-term posterior articular surface collapse is reduced, and the curative effect of comminuted calcaneus fracture is improved.

The invention relates to the technical field of biological medicine, in particular to selenium and application of a selenium composition, a nasal composition and application of the nasal composition. The invention provides application of selenium in inhibition of nasal cavity or airway epithelium inflammatory factor expression and a nasal composition containing the selenium. The selenium element is used for regulating and controlling a signal channel, so that the expression of key inflammatory factors in epithelial cells of the nasal cavity or the airway is effectively reduced, the level of reactive oxygen species (ROS) of the epithelial cells of the nasal cavity or the airway is reduced, and the dual effects of inflammation resistance and oxidation resistance are achieved. Therefore, the nasal composition containing the selenium element can effectively block the preinflammatory syndrome driven by upstream oxidative stress by regulating and controlling dual mechanisms of inflammation and oxidative stress reaction, and nasal cavity or airway diseases such as rhinitis and allergic rhinitis are relieved and treated from the source.