143results about How to "Increase activity" patented technology

Linkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment. A method for preparing maytansinoids bearing a thioether moiety and a reactive group which allows the maytansinoid to be linked to a cell-binding agent in essentially a single step is also provided.

A rehabilitation device, comprising a movement element capable of controlling at least one motion parameter of a portion of a patient; a brain monitor which generates a signal indicative of brain activity; and circuitry including a memory having stored therein rehabilitation information and which inter-relates said signal and movement of said movement element as part of a rehabilitation process which utilizes said rehabilitation information.

Certain cardiac arrhythmias can be prevented by appropriate electrical stimulation of autonomic nerves innervating the heart. An implantable cardiac rhythm management device is configured to deliver such stimulation when an autonomic imbalance is predicted to be present via an endovascular electrode. Autonomic imbalance may be predicted to be present based upon circadian rhythms, detected heart rates, or detected heart rate variability.

A promoted carbon and / or non-carbon base sorbent are described that are highly effective for the removal of mercury from flue gas streams. The promoted sorbent comprises a carbon and / or non-carbon base sorbent that has reacted with and contains forms of halogen and halides. Optional components may be added to increase and / or preserve reactivity and mercury capacity. These may be added directly with the base sorbent, or in-flight within a gas stream (air, flue gas, etc.), to enhance base sorbent performance and / or mercury capture. Mercury removal efficiencies obtained exceed conventional methods. The promoted sorbent can be regenerated and reused. Base sorbent treatment and preparation methods are also described. New methods for in-flight preparation, introduction, and control of the active base sorbent into the mercury contaminated gas stream are described.

In one aspect, the present invention provides methods for the classification, diagnosis, prognosis, theranosis, and / or prediction of an outcome of an autoimmune disease in a subject.

An adsorbent for organic sulfur compound removal from mineral, vegetable or animal oils useful to protect a hydrogenation catalyst against poisoning, wherein the adsorbent is a zinc-exchanged form of low silica faujasite with a silica to alumina ratio from about 1.8 to about 2.1, wherein the adsorbent contains an inequivalent excess of zinc cations from about 8 to about 20% (equiv.) and a process for manufacture and use of the adsorbent.

The invention relates to modulation of LKB1 or AMP kinase protein activity for treating disorders including diabetes and cancer. The invention also relates to screening for agents that modulate the activity of LKB1 or AMP kinase protein, which are useful in the treatment of diabetes and cancer, as well as preparing compounds for treatment of diabetes and cancer.

In an embodiment, a method is disclosed to increase the activity of an ionic liquid catalyst comprising emulsifying the ionic liquid catalyst with one or more liquid components. In an embodiment, a method is disclosed comprising introducing into a reaction zone a monomer feed and a reduced amount of ionic liquid catalyst and controlling an amount of shear present in the reaction zone to maintain a desired conversion reaction of the monomer. In an embodiment, a catalyzed reaction system is disclosed comprising a reactor configured to receive one or more liquid components and ionic liquid catalyst; a device coupled to the reactor for adding high shear to the liquid components and ionic liquid catalyst; and a controller coupled to the device for adding high shear and configured to control the amount of shear added to a catalyzed reaction zone to maintain a conversion reaction.

Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides CARD-9, CARD-10, or CARD-11, fusion proteins, antigenic peptides and anti-CARD-9, CARD-10, or CARD-11 antibodies. The invention also provides CARD-9, CARD-10, or CARD-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-9, CARD-10, or CARD-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and / or conditions related to this novel human protein and these novel human antibodies.

Disclosed is a method of preparing an ultra-high molecular weight, linear low density polyethylene with a catalyst system that comprises a bridged indenoindolyl transition metal complex, a non-bridged indenoindolyl transition metal complex, an alumoxane activator and a boron-containing activator. The ultra-high molecular weight, linear low density polyethylene has a weight average molecular weight greater than 1,000,000 and a density less than 0.940 g / cm3.

Disclosed is a compound represented by the formula (I) below, which has a glucokinase-activating effect and is thus useful for treatment of diabetes or obesity, or a pharmaceutically acceptable salt thereof.In the formula, R1 represents an aryl or the like; R11 represents an aryl or the like; R2 represents a formyl or the like, R3 represents a C1-6 alkyl or the like; R3 represents a hydrogen atom or the like; Z1 represents —O— or the like; Z2 represents —O— or the like; Y1-Y4 respectively represent a carbon atom or a nitrogen atom; ring A represents a heteroaryl group; X represents a carbon atom or the like; m represents an integer of 0-2; and q represents an integer of 0-2.

The present disclosure teaches that the recombination of homologous sequences of P450 enzymes, with the aid of SCHEMA to predict a resulting protein structure, is able to generate libraries of chimeras with significant functional diversity. Additionally, the members of these libraries demonstrate superior or unexpected new properties, which correlate with other factors that are observable in the library. Thus, the making of libraries of optimized P450 enzymes, the analysis of libraries to identify an optimized subset, and the optimized chimeras with improved or altered functionalities are all taught in the present disclosure.

The present invention is directed to methods of altering the degree of internalization of a Clostridial toxin; methods of preventing or treating botulinum toxin intoxication; methods of treating metabolic disorders, muscular disorders, nervous system disorders, and / or pain conditions; methods of inhibiting the formation of lipid rafts on cell membranes; methods of treating a disease associated with lipid rafts; and methods of identifying a compound that alters the internalization of a Clostridial toxin.

The present invention relates to methods and compositions designed for the treatment, management, or prevention of a non-neoplastic hyperproliferative cell or excessive cell accumulation disorders, particularly those involving hyperproliferation of epithelial or endothelial cells. In one embodiment, the methods of the invention comprise the administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and increase EphA2 cytoplasmic tail phosphorylation and / or increase EphA2 autophosphorylation in cells which EphA2 has been agonized. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and reduce EphA2 activity (other than autophosphorylation). In another embodiment, the methods of the invention comprise administration of an effective amount of one or more EphA2 agonistic agents that bind to EphA2 and decrease a pathology-causing cell phenotype (e.g., a pathology-causing epithelial cell phenotype or a pathology-causing endothelial cell phenotype). In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more EphA2 agonistic agents that are EphA2 antibodies that bind to EphA2 with a very low Koff rate. In preferred embodiments, agents of the invention are monoclonal antibodies. The invention also provides pharmaceutical compositions comprising one or more EphA2 agonistic agents of the invention either alone or in combination with one or more other agents useful in therapy for non-neoplastic hyperproliferative cell or excessive cell accumulation disorders.

The invention describes a catalyst comprising at least one material with a hierarchical porosity comprising silicon and at least one hydrodehydrogenating element from group VIB and / or group VIII of the periodic table of the elements. Said material with a hierarchical porosity comprising silicon is constituted by at least two elementary spherical particles, each of said spherical particles comprising zeolitic nanocrystals having a pore size in the range 0.2 to 2 nm and a matrix based on silicon oxide, which is mesostructured, having a pore size in the range 1.5 to 30 nm and having amorphous walls with a thickness in the range 1 to 30 nm, said elementary spherical particles having a maximum diameter of 100 μm. The matrix based on silicon oxide may contain aluminium. The catalyst also optionally comprises at least one doping element in a controlled quantity selected from phosphorus, boron and silicon, optionally at least one element from group VB of the periodic table of the elements, and optionally an element from group VIIA. The invention also concerns hydrocracking / hydroconversion and hydrotreatment processes employing said catalyst.

The invention discloses a gesture-based interactive teaching method and system. Students input gestures at an intelligent terminal and build a gesture template library; interaction is carried out through a WiFi router, a server and a teacher computer through the input gestures; and the gestures include 'uploading', 'intercepting', 'downloading', 'clearing', 'questioning' and 'answering'. The students build templates through custom gestures and interact with a teacher through the gestures, so that the activeness of the class and the participation degree of the teaching link are improved; and meanwhile, gesture operation is simple and convenient, and the intelligent terminal is easy to carry.

The embodiment of the invention discloses an instant messaging message interaction method and device and a computer readable storage medium. According to the scheme, the method includes: receiving a session message of a target session group; performing scene analysis on the session message, and determining a preset session scene where the target session group is located according to a scene analysis result; determining a target semantic analysis algorithm corresponding to a preset session scene, performing semantic analysis on the session message through the target semantic analysis algorithm,and generating a to-be-replied message according to a semantic analysis result; and sending the to-be-replied message to the target session group. A proper target semantic algorithm is determined through different preset session scenes; semantic analysis is carried out on the session message based on the target semantic algorithm, the to-be-replied message matched with the session scene is generated for interaction, the chat atmosphere in the target session group is better adjusted, the interaction efficiency of the instant messaging information is improved, and then the activeness of the session group is improved.

The invention provides an electronic gift sending control method, a device and a mobile terminal thereof. The method comprises steps of: responding to a control instruction which is triggered through acting on a control interface of an anchor in a live broadcasting room and used of displaying an electronic gift column and displaying the electronic gift column; responding to a sending instruction which is generated through acting on the electronic gift column, wherein the sending instruction comprises sending information which is used for assigning at least one description attributed of a to-be-sent electronic gift, and sending the sending request including the sending information to a server; and receiving and displaying electronic gift sending result information which is fed back to the live broadcasting room through response to the sending request of the server. According to the invention, ports for sending gifts to members in the live broadcasting room by the anchor are increased; more gift sending modes in the live broadcasting room are provided; interactivity between the anchor and the members is improved; the electronic gifts are quite exclusive; the live broadcasting room is more interesting; activeness in the live broadcasting room is well improved; and interaction experience between users is improved.

A method of improving penile erections comprises simultaneously stimulating nerves of the ventral and dorsal sides of the penis by simultaneously applying mechanical vibrations to the ventral and dorsal sides of the penis. The vibrations are applied by moving vibratory elements into contact with the penis in directions perpendicular to the ventral and dorsal sides; the vibrations are removed by moving the vibratory elements out of contact with the penis in directions perpendicular to the ventral and dorsal sides; and the vibratory elements are moved into and out of contact with the penis by the person whose penis is being stimulated. Apparatus for carrying out the method is also disclosed.

The invention relates to a hydroxamate composition for collection of minerals by froth flotation, the composition including an aqueous mixture of hydroxamate wherein the pH of the composition is at least 11 and a method of collecting mineral values from an aqueous ore slurry by froth flotation.

The present invention relates to the use of sphingolipids for the preparation of a food item, a food supplement and / or a medicament for the treatment and / or prevention of insulin resistance, diabetes mellitus type 2 and / or Metabolic Syndrome. In particular, the invention relates to the use of a sphingolipid with the general formula (I): wherein Z is R3 or —CH(OH)—R3; A is sulphate, sulphonate, phosphate, phosphonate or —C(O)O—; R1 is H, hydroxyl, alditol, aldose, an alcohol, C1-C6 alkyl or amino acid; R2 is H or unsaturated or saturated (C1-C30) alkyl chain; R3 is unsaturated or saturated (C1-C30) alkyl chain; Q1 is a primary amine group (—NH2), secondary amine group (—NH—) or an amide group (—NH—CO—); and t is 0 or 1, or a precursor, a derivative or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the prevention and / or treatment of a disorder selected from the group consisting of insulin resistance, diabetes type 2 and Metabolic Syndrome.

The invention relates to a personalized MI-EEG training and collecting method based on mirror image virtualization and Skinner reinforced learning. According to the method, a mirror image therapy in the rehabilitation therapy field and a Skinner reinforced learning theory are integrated into the MI-EEG training and collecting process; personalized audio-visual combined stimulation is designed in a training mode, an unaffected hand wears a data glove and performs opening and holding actions in a more relaxed state, data of the actions of the unaffected hand is read and decoded in real time through a computer serial interface, and then the actions of a mirror image virtualization affected hand model in a collecting interface is muzzled. According to the method, a subject stimulates and induces movement of the mirror image virtualization hand through the actions of the unaffected hand of the subject, the electrical activity of mirror image neurons in the movement function area of the brain is enhanced, and a closed-loop electroencephalogram collecting and controlling mode is designed on the basis of the Skinner reinforced learning theory to test the training effect; meanwhile, internal motivation is further enhanced through Skinner online reward feedback, and the MI-EEG quality is improved. The method is easy to operate and is expected to achieve better actual application.

This invention relates to a hydroprocessing process with improved catalyst activity when hydroprocessing petroleum based feedstock or an oxygen containing feedstock. This invention also relates to a hydrotreating process with improved hydrodesulfurization (HDS) activity of a hydrotreating catalyst such as Co / Mo by co-feeding carbon monoxide or its precursors. Such inventive process confirms that adding a small amount of CO to H2 in a hydrotreater for a few days leads to an increase in product sulfur due to the inhibition of CO on the hydrotreating catalyst such as Co / Mo. However, it has been unexpectedly found that after the CO was removed from the hydrogen stream, product sulfur levels decreased to values below they were before CO addition which means the activity of the hydrotreating catalyst increased after the CO treatment.

Pharmaceutical compositions of NF-AT agonists may be used to promote nerve regeneration or to reduce or inhibit secondary nerve degeneration which may otherwise follow primary CNS or PNS injury, e.g., trauma (e.g., blunt trauma, penetrating trauma), compression [e.g., compression due to tendons and / or inflamed synovial membrane such as in carpal tunnel syndrome], bones [for instance sciatica], or growths [benign or cancerous, including growth of the nerves themselves or of surrounding tissue]) hemorrhagic stroke, ischemic stroke or damages caused by surgery such as tumor excision. In certain embodiments, NF-AT agonists may be used to treat spinal cord injuries and promote nerve grafts.

The invention relates a music user group management method. The method includes the following steps: during operation of a music application, a play interface of the music application is displayed, wherein the play interface includes at least one music option and an entrance interface object of a music user group associated with the music option; when a selection operation of a specific entrance interface object on the play interface, carried out by a current login user of the music application, is received, a group entering request is sent to a server so that the server is made add the current login user into a music user group corresponding to a selected entrance interface object. The invention also provides a music user group management device and system. Through use of the music user group management method, device and system, interaction and communication of music users, which have common music interest, in a music application can be realized and the activeness of the music users is improved.

The invention relates to a horizontal grinding mill with built-in classifying turbine, the technical solution of which is that a grinding chamber [18] is filled with grinding medium [6], a medium discharging valve [20] is installed on the middle of the bottom of a cylinder [7], a feeding pipe [10] is above a right end cover [9] of the grinding chamber [18] and a medium discharging pipe [2] is concentrically communicated with the grinding chamber [18] by a left end cover [3]. The length of the cylinder [7] is 1.5 to 2.5 times of the diameter thereof. A fairing [4] is fixedly installed on the left end cover [3] of the grinding chamber [18]. A classifying turbine [5] is vertically installed on the left end of a spindle [13]. A clearance between the classifying turbine [5] and the left end cover [3] is 5mm to 10mm. Five to eight mixing turbines [8] are vertically installed on the spindle [13]. The distance between the mixing turbines [8] decreases gradually from left to right and the right distance is 0.9 to 0.95 times of the left distance. The right end of the spindle [13] is connected with a driving mechanism by the right end cover [9] and a sealing device [11]. The invention has low starting power and can grind and classify with a function of selectively grinding.

The invention discloses a blowing flow distributing device for double-roller thin-strip continuous casting. The blowing flow distributing device comprises a groove-shaped flow distributor body; air inlets are formed in the two ends of the flow distributor body; channels formed in the air inlets form vertical air inlet channels and a bottom air inlet channel; an air outlet group is formed in the bottom air inlet channel; the flow distributor body is internally provided with a steel liquid containing chamber, and the molten steel containing chamber is provided with a molten steel partition plateso as to form an upper molten steel containing chamber body and a lower molten steel containing chamber body; a molten steel falling hole group is formed in the molten steel partition plate; and a molten steel tapping hole group is formed in the wall surface of the lower molten steel containing chamber body located at the lower part of the molten steel partition plate. According to the blowing flow distributing device, non-uniform flowing of outlet waterflow can be effectively buffered, the tapping amount of tapping holes and the flow rate of molten steel can be effectively decreased, so thatthe high-temperature molten steel can be provide heat for a triangular molten bath from the lower part, the molten steel flowing out of the molten steel tapping holes can be drive to form an upward floating effect and promote upward floating of molten steel inclusions of the molten bath with the coordination of inert gas, the activity degree of the surface of the molten bath can be increased, cold steel membranes can be reduced, and the thin-strip continuous casting stability and the thin-strip quality can be improved.

The invention pertains to the use and production of non-neurotoxic plasminogen activating factors e.g. of Desmodus rotundus (DSPA) for the therapeutic treatment of stroke in humans in order to provide a new therapeutic concept for treating stroke in humans.

The present invention relates to a method for the chemoprevention and treatment of cancer, by administering a pharmaceutical composition comprising a carotenoid derivative, such as a derivative of lycopene, a- and b-carotene, phytoene, phytofluene, lutein, zeaxanthin, α- and β-cryptoxanthin, canthaxanthin, astaxanthin, or other carotenoid. The carotenoid derivative is a carotenoid oxidation product, and is preferably an aldehyde derivative, a dialdehyde derivative or a ketone derivative. The carotenoid derivative can be a derivative of any naturally occurring carotenoid, such as those found in tomatoes and other fruits and vegetables.