13results about How to "Increase bone density" patented technology

The invention provides a mesenchymal stem cell composition as well as a preparation method and application thereof in knee joint products, and belongs to the technical field of medicines. The invention relates to application of a mesenchymal stem cell combined naringin derivative in preparation of medicines for treating osteoporosis and repairing knee joint injury and arthritis. The naringin derivative is prepared from naringin through an ether esterification reaction, the metabolic cycle of the naringin derivative is prolonged and the water solubility is improved while the original activity is maintained, so that the free drug concentration and tissue infiltration capacity in bones are improved, the bioavailability of the naringin derivative is improved, and the bioavailability of the naringin derivative is improved. The prepared mesenchymal stem cell composition can induce mesenchymal stem cell osteogenic differentiation and improve bone repair capacity, has a good intervention effect on osteoporosis, has a sustained and controlled release effect and prolongs medicinal time.

The utility model provides a palm work multifunctional all -in -one, including base, be provided with on base: beat board, with base hinged, its hinged point is equipped with interval between the gravity center of beat board, speed reducer motor, drive rod, its one end with the drive end fixed connection of speed reducer motor, the other end makes the circular motion, is used for driving beat board one end to drop or to separate beat board, when drive rod separates beat board, the other end of beat board moves freely under the action of gravity and strikes hand. Through the beat board automatic hammering of speed reducer motor drive, convert traditional passive beating training into active force mode, utilize beat board gravitational potential energy conversion impact force, improve the bone density of hand significantly.

The invention belongs to the technical field of microorganisms and compound nutrients, and particularly relates to a postbiotic preparation and composition for improving activity of gamma-aminobutyric acid and promoting calcium absorption and application of the postbiotic preparation and composition in sleep improvement and bone health. Through the synergistic effect of the specific metagen preparation and the gamma-aminobutyric acid, the multi-dimensional technical breakthrough is realized, and the physiological activity and the application value are remarkably improved. In the aspect of bioavailability, the intestinal barrier function is improved and the pH value of the intestinal tract is adjusted to be weakly acidic through the postbiotics, so that the concentration of serum GABA is increased by 2-3 times compared with that of single use, and the calcium absorption rate is increased from 30% to 55-60%. And on the aspect of function synergy, the limitation of single effect in the prior art is broken through, dual-function synergy of'sleep regulation-bone health 'is realized, meanwhile, the vicious circle of'poor sleep-calcium loss' is improved, and good practical application value is achieved.

This invention relates to a nutritional composition for promoting bone development and its applications. The invention provides applications of the nutritional composition or preparations comprising said nutritional composition, including: (1) preparing food products; (2) preparing health products for promoting bone development, increasing height, and / or improving bone density; (3) preparing drugs or drug compositions for promoting bone development, increasing height, increasing bone density, treating or preventing osteoporosis, and / or treating or preventing skeletal dysplasia; and (4) promoting bone development, increasing height, and / or improving bone density for non-therapeutic purposes; wherein said nutritional composition comprises medium- and long-chain triglycerides (MLCT) and 1,3-diunsaturated fatty acid-2-palmitoyltriglycerides (UPU).

The invention relates to fermented milk containing human milk oligosaccharide 2-FL and having a bone mineral density improving function. The invention provides application of human milk oligosaccharide 2-FL in preparation of a composition for improving bone health, and further provides a composition which contains the human milk oligosaccharide 2-FL and has a function of improving bone health. The composition comprises human milk oligosaccharide 2-FL and a leavening agent, wherein the leavening agent is one or a mixture of more of streptococcus thermophilus, lactobacillus bulgaricus and a vitamin K2-producing leavening agent. Compared with other technical schemes of the same type for enhancing the bone mineral density, the calcium intake of a subject is not additionally increased, the risk that the subject suffers from organ calculi is reduced, the application range is wider, and the preparation method is suitable for being applied to various fermented milk products.

The invention relates to a composition with a function of improving bone mineral density, application of the composition and a preparation method of related health-care products or foods, and the composition comprises the following components in parts by weight: 0.5-4.5 parts of D-glucosamine hydrochloride, 0.5-3 parts of calcium carbonate, 0.1-1.5 parts of sodium chondroitin sulfate, 0.5-2.5 parts of American ginseng extract, 0.2-2 parts of salvia miltiorrhiza extract, 0.15-1.5 parts of radix paeoniae alba extract and 0.1-1 part of turmeric extract. The composition is prepared into a medicine, a health care product or a food to increase the bone mineral density. According to the composition, green, natural and high-quality raw materials and auxiliary materials are selected, the composition is prepared from the perspective of traditional Chinese medicine, modern nutriology and modern pharmacology, calcium supplement, articular cartilage protection and inflammation relieving are integrated, the formula plays a comprehensive role in increasing the bone mineral density in different links, and the effect of increasing the bone mineral density under the effect of three pipes is achieved. The composition can be prepared into medicines, health-care products or foods, the preparation process is simple, and the prepared product is green, safe and remarkable in curative effect and has a good market prospect.

The invention relates to the technical field of biological medicines and functional nucleic acid molecules, and discloses pearl mussel source miRNA and application thereof, a biological preparation and application thereof. The pearl mussel source miRNA is miRNA derived from a pearl mussel pallium exosome, contains a sequence shown in SEQ ID NO: 1, and can be modified by phosphorylation, locked nucleic acid and the like to enhance the stability. The biological preparation containing the miRNA can be used for preparing a medicine for preventing and / or treating osteoporosis or functional food for promoting bone mineralization, and the bone mineral density and the bone microstructure are improved by promoting osteoblast proliferation, differentiation and mineralization. According to the invention, marine biological resources which are natural in source and high in safety are utilized, and new active ingredients and technical schemes are provided for prevention and treatment of osteoporosis.

This invention discloses a neutral homogeneous polysaccharide from Rehmannia glutinosa, its preparation method, and its applications, belonging to the field of traditional Chinese medicine preparation technology. The polysaccharide is mainly composed of galactose, glucose, and fructose in a molar ratio of 2.72:1.17:1.11, with a weight-average molecular weight of 2152 Da. The neutral polysaccharide from Rehmannia glutinosa can exert a therapeutic effect on osteoporosis by increasing bone mineralization and bone density; it can also promote the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), showing significant application effects in the preparation of stem cell therapy drugs for bone defects. The neutral homogeneous polysaccharide from Rehmannia glutinosa shows great application potential in the preparation of drugs for treating osteoporosis and as a stem cell therapy (especially bone regeneration therapy based on bone marrow mesenchymal stem cells). This provides new candidate substances and research directions for developing efficient and safe treatment strategies for bone metabolic diseases derived from traditional Chinese medicine.

This invention relates to the field of dandelion total flavonoids application technology, and discloses the application of dandelion total flavonoids in the preparation of products for the prevention and treatment of osteoporosis. The extraction method of dandelion total flavonoids according to this invention includes the following steps: 1) drying and pulverizing the whole dandelion plant to obtain dandelion powder; 2) mixing the dandelion powder with 60% ethanol (volume fraction), ultrasonically treating, and then filtering; 3) mixing the filtered residue with 40% ethanol (volume fraction), heating and refluxing, and then filtering; 4) combining the filtrates, concentrating, and drying to obtain dandelion total flavonoids. This invention, through biological and cellular level studies, has found that dandelion total flavonoids can effectively improve bone density and bone quality; therefore, dandelion total flavonoids can be applied to products for the prevention and treatment of osteoporosis.

The invention provides a composition for preventing bone loss caused by cold exposure as well as a preparation method and application of the composition, and belongs to the technical field of pharmaceutical compositions. The composition provided by the invention is prepared from the following components in parts by weight: 1.18 to 1.58 parts of radix angelicae sinensis extract, 1.18 to 1.58 parts of flos carthami extract, 1.18 to 1.58 parts of semen persicae extract and 2.56 to 2.96 parts of fructus crataegi extract. The preparation method of the composition comprises the following steps: weighing the polymer carrier, adding the polymer carrier into precooled purified water, and adding ethanol; weighing a raw material mixture, and adding the raw material mixture into the polymer solution; performing spray drying to obtain fine powder, and performing vacuum drying to obtain the composition for preventing bone loss caused by cold exposure. The composition for preventing bone loss caused by cold exposure, prepared by the invention, has high solubility and high dissolution rate, and active ingredients take effect quickly; the bone loss caused by cold exposure can be prevented.

The application relates to the technical field of active peptides, and discloses an egg yolk-derived active peptide for promoting bone growth and a preparation method. The preparation method is as follows: the poultry eggs are cleaned, selected, sterilized and dried to obtain sterile poultry eggs; the egg yolk is subjected to spray drying to obtain egg yolk powder, and the egg yolk powder is subjected to defatting treatment to obtain defatted egg yolk powder; the defatted egg yolk powder is sieved, and deionized water is added to obtain a defatted egg yolk powder suspension; the pH and temperature of the defatted egg yolk powder suspension are adjusted, and enzyme hydrolysis is carried out to obtain an enzyme hydrolysate; the enzyme hydrolysate is inactivated and stored; the enzyme hydrolysate is added with calcium lactate and zinc lactate, and thermophilic fat Bacillus stearothermophilus is added, and fermentation is carried out to obtain a fermentation liquor; and an active peptide solution is separated. The application adopts the above egg yolk-derived active peptide for promoting bone growth and the preparation method, small-molecular-weight active peptides are obtained through step-by-step enzyme hydrolysis and fermentation, the active peptides are easy to absorb, and calcium ions and zinc ions are added during the fermentation, so that the active peptides are chelated with metal ions, growth and bone development are promoted.

This invention provides a composition for improving bone density, its preparation method, application, and product, belonging to the technical field of bone and joint health products. The composition for improving bone density comprises the following components in parts by weight: 0.1-70 parts collagen peptides; 0.01-2 parts casein phosphopeptides; 7-40 parts milk mineral salts; 0.5-40 parts fructooligosaccharides; and 0.01-1 parts vitamin D. In the composition provided by this invention, the casein phosphopeptides, vitamin D, fructooligosaccharides, collagen peptides, and milk mineral salts can interact to increase bone calcium and bone density, thus preventing or improving osteoporosis.

This invention discloses a method for preparing hazelnut oil-based oleogel food material, comprising the following steps: (1) Oil extraction: Hazelnuts are soaked overnight, ground with cell wall breaking, stirred under alkaline conditions, filtered, centrifuged, and the cream layer is collected to obtain hazelnut oil. The hazelnut oil is then diluted under acidic conditions to obtain a hazelnut oil suspension; (2) Emulsion template preparation: The gelling agent hydrogel system is stirred in a water bath, and the hazelnut oil suspension and gelling agent are dispersed and sheared. The mixture is adjusted to acidic conditions and refrigerated overnight to prepare a hazelnut oil emulsion gel; (3) Hazelnut oil-based oleogel preparation: The hazelnut oil emulsion gel is freeze-dried, dispersed, sheared, and stirred to obtain a hazelnut oil-based oleogel. This invention breaks through the limitations of existing natural plant oil and oleogel delivery carrier technologies, constructs a hazelnut oil-based oleogel model, and provides a scientific theory and technical method for studying oleogel delivery systems using multifunctional high-internal-phase plant oils.