42results about How to "Increase bone density" patented technology

The invention discloses a nutritional composition. The nutritional composition comprises vitamin D, basic protein and lysine, wherein in the nutritional composition, the mass ratio of the vitamin D to the basic protein to the lysine is (0.005 to 0.020) to (70 to 200) to (1000 to 3000). The invention also discloses an application of the nutritional composition and a formula food containing the nutritional composition. According to the nutritional composition disclosed by the invention, the vitamin D, the basic protein and the lysine can be matched with one another, so that linear growth of bones of children and teenagers can be effectively promoted, bone health and bone strength can be enhanced, and height development can be promoted.

The invention discloses a bone health tablet candy rich in marine peptide calcium chelate and a preparation method thereof, and belongs to the technical field of polypeptide biologication.The calcium chelating peptide provided by the invention has an amino acid sequence as shown in SEQ ID No.1, the specific sequence is GETGPA (F21-1), and the calcium binding capacity is 4.72 + / -1.06 mu g / mg. The bone health tablet candy provided by the invention has relatively good calcium absorption promoting activity. A mouse experiment result shows that no adverse effect is caused to mouse growth, high bone transition caused by osteoporosis can be reversed, the bone biomechanical property of the osteoporosis mouse is improved, and then the effect of enhancing the bone mineral density is achieved.

The invention provides a plant lactobacillus for promoting skeletal development in a growth period as well as application and a product of the plant lactobacillus, and belongs to the technical field of microorganisms. The invention provides a lactobacillus plantarum BL25 and a probiotic preparation thereof, the preservation number of the lactobacillus plantarum BL25 is CGMCC (China General Microbiological Culture Collection Center) No.33117, stachyose is adopted as prebiotics, and compared with other prebiotics, the lactobacillus plantarum BL25 can obviously promote the activity of the lactobacillus plantarum BL25. The plant lactobacillus BL25 and the probiotic preparation thereof have the effect of resisting the severe environment of gastrointestinal tracts, and can increase the length of femur and bone density, promote the development of a bone microstructure, improve bone metabolism, increase osteogenesis markers and reduce osteoclast markers, so that the skeletal development in the life growth period is promoted.

The invention belongs to the technical field of biological medicines, and particularly discloses a collagen peptide composition for enhancing immunostimulation osteoblast synthesis and a preparation method thereof, the collagen peptide composition comprises the following components by mass: 0.05-0.2% of taurine, 0.1-1% of vitamin C, 5-20% of type II collagen peptide, 5-20% of type III collagen peptide, and the balance of bovine bone collagen peptide. On the basis of the bovine bone collagen peptide, under the action of the taurine, the vitamin C, the II type collagen peptide, the III type collagen peptide and the red date extract, immunity can be effectively improved, osteoblasts are stimulated to synthesize the collagen peptide, and therefore the bone mineral density is effectively increased, and the osteoporosis is reduced. Wherein the red date extract and the bovine bone collagen peptide have a remarkable synergistic effect.

The invention provides a medical biological rare earth magnesium alloy material. The medical biological rare earth magnesium alloy material comprises magnesium, gadolinium, zinc, zirconium, dysprosium and scandium. According to the rare earth magnesium alloy material provided by the invention, different contents of rare earth gadolinium, dysprosium, scandium, zinc and zirconium are added to improve the casting performance and the processing performance of a melt, and the alloy structure is improved through solid solution strengthening, dispersion strengthening and grain refinement effects, so that the strength and the ductility are improved; meanwhile, the selection design of the alloy elements strictly conforms to the limitation of biotoxicity, and the biological activity of the alloy elements can not be influenced, so that excellent mechanical properties and processability are obtained while good biocompatibility is kept, and the alloy elements play roles in accelerating osteogenesis and promoting bone tissue growth while playing a fixing role; the non-toxicity, the degradability and the high therapeutic property are really realized.

The invention relates to the technical field of traditional Chinese medicine, and discloses a plaster for treating bone fracture and a preparation method thereof, and the plaster comprises the following raw materials: peach kernel, safflower, ligusticum wallichii, radix cyathulae, rhizoma drynariae, radix angelicae pubescentis, notopterygium root, eucommia ulmoides, astragalus membranaceus, pseudo-ginseng, native copper, dragon's blood, catechu, angelica sinensis, radix rehmanniae, gentiana macrophylla, radix saposhnikoviae, earthworm, centipede, scorpion, ground beetle, liquorice, frankincense, myrrh, yellow lead, sesame oil and other auxiliary materials. Pseudo-ginseng is added into the formula, the effects of promoting blood circulation to remove blood stasis, diminishing swelling and relieving pain of pseudo-ginseng are utilized, absorption of blood stasis of the bone fracture part can be accelerated, then pain and swelling caused by blood stasis blocking are remarkably relieved, blood circulation is promoted, and injury repair is promoted, and radix angelicae sinensis and radix rehmanniae are added into the formula, and the effects of replenishing blood and promoting blood circulation of radix angelicae sinensis and nourishing yin and cooling blood of radix rehmanniae are utilized, so that the bone fracture can be cured, and the bone fracture can be cured. And blood generation and local microcirculation improvement can be promoted, so that the blood supply and oxygen supply capacity of a bone fracture repair part is enhanced, and soft tissue repair is accelerated.

The invention provides a mesenchymal stem cell composition as well as a preparation method and application thereof in knee joint products, and belongs to the technical field of medicines. The invention relates to application of a mesenchymal stem cell combined naringin derivative in preparation of medicines for treating osteoporosis and repairing knee joint injury and arthritis. The naringin derivative is prepared from naringin through an ether esterification reaction, the metabolic cycle of the naringin derivative is prolonged and the water solubility is improved while the original activity is maintained, so that the free drug concentration and tissue infiltration capacity in bones are improved, the bioavailability of the naringin derivative is improved, and the bioavailability of the naringin derivative is improved. The prepared mesenchymal stem cell composition can induce mesenchymal stem cell osteogenic differentiation and improve bone repair capacity, has a good intervention effect on osteoporosis, has a sustained and controlled release effect and prolongs medicinal time.

The utility model provides a palm work multifunctional all -in -one, including base, be provided with on base: beat board, with base hinged, its hinged point is equipped with interval between the gravity center of beat board, speed reducer motor, drive rod, its one end with the drive end fixed connection of speed reducer motor, the other end makes the circular motion, is used for driving beat board one end to drop or to separate beat board, when drive rod separates beat board, the other end of beat board moves freely under the action of gravity and strikes hand. Through the beat board automatic hammering of speed reducer motor drive, convert traditional passive beating training into active force mode, utilize beat board gravitational potential energy conversion impact force, improve the bone density of hand significantly.

The invention belongs to the technical field of poultry farming, and particularly relates to a compound feed for effectively improving sternum calcification of cherry valley hang white meat ducks. The feed contains a nutrient supplement, and every 1 part by weight of the nutrient supplement comprises 50 g of zinc methionine, 50 g of manganese methionine, 3000 IU of 25-hydroxyvitamin D3, 100 g of magnesium oxide, 300 g of blue kadsura and 500 g of eggshell powder. The functional nutrition enhancer can improve sternum calcification of cherry valley hang white meat ducks. In the invention, the conventional nutritional indexes and the required amount of trace elements and vitamins of the cherry valley-hang white meat ducks are researched, and the formed compound feed preparation technology is more scientific and more comprehensive in consideration; the functional nutrition enhancer is adopted, so that the sternum calcification degree of the meat ducks is effectively improved, the tibia strength is improved, the occurrence rate of leg diseases is improved, and the breeding benefits are improved.

The invention belongs to the technical field of microorganisms and compound nutrients, and particularly relates to a postbiotic preparation and composition for improving activity of gamma-aminobutyric acid and promoting calcium absorption and application of the postbiotic preparation and composition in sleep improvement and bone health. Through the synergistic effect of the specific metagen preparation and the gamma-aminobutyric acid, the multi-dimensional technical breakthrough is realized, and the physiological activity and the application value are remarkably improved. In the aspect of bioavailability, the intestinal barrier function is improved and the pH value of the intestinal tract is adjusted to be weakly acidic through the postbiotics, so that the concentration of serum GABA is increased by 2-3 times compared with that of single use, and the calcium absorption rate is increased from 30% to 55-60%. And on the aspect of function synergy, the limitation of single effect in the prior art is broken through, dual-function synergy of'sleep regulation-bone health 'is realized, meanwhile, the vicious circle of'poor sleep-calcium loss' is improved, and good practical application value is achieved.

This invention relates to a nutritional composition for promoting bone development and its applications. The invention provides applications of the nutritional composition or preparations comprising said nutritional composition, including: (1) preparing food products; (2) preparing health products for promoting bone development, increasing height, and / or improving bone density; (3) preparing drugs or drug compositions for promoting bone development, increasing height, increasing bone density, treating or preventing osteoporosis, and / or treating or preventing skeletal dysplasia; and (4) promoting bone development, increasing height, and / or improving bone density for non-therapeutic purposes; wherein said nutritional composition comprises medium- and long-chain triglycerides (MLCT) and 1,3-diunsaturated fatty acid-2-palmitoyltriglycerides (UPU).

The invention relates to fermented milk containing human milk oligosaccharide 2-FL and having a bone mineral density improving function. The invention provides application of human milk oligosaccharide 2-FL in preparation of a composition for improving bone health, and further provides a composition which contains the human milk oligosaccharide 2-FL and has a function of improving bone health. The composition comprises human milk oligosaccharide 2-FL and a leavening agent, wherein the leavening agent is one or a mixture of more of streptococcus thermophilus, lactobacillus bulgaricus and a vitamin K2-producing leavening agent. Compared with other technical schemes of the same type for enhancing the bone mineral density, the calcium intake of a subject is not additionally increased, the risk that the subject suffers from organ calculi is reduced, the application range is wider, and the preparation method is suitable for being applied to various fermented milk products.

The present application provides a solid beverage of forest frog collagen composite peptides, which contains forest frog collagen peptide powder, collagen peptides, milk mineral salts, arabinose, L-calcium lactate, ginger extract, steviol glycosides, taurine, xylitol, oligoisomaltose, maltodextrin, vitamin C, casein phosphopeptide, theanine, edible flavors and stabilizers. The forest frog collagen peptide powder and the polypeptide components in the solid beverage of the present application have the effects of anti-oxidation and promoting bone growth; calcium lactate, forest frog collagen peptide powder and milk mineral salts provide a large amount of calcium ions, which provide a good nutritional environment for bone growth. The forest frog collagen peptide powder in the solid beverage of the present application uses the residue after extraction for secondary extraction and development, realizes comprehensive utilization and promotes environmental protection. Save raw material costs.

The invention discloses a gRNA sequence and application thereof in construction of an osteosclerosis animal model, and provides a pair of new gRNA sequences for constructing an LRRK1 knockout mouse, and the LRRK1 knockout mouse has typical osteosclerosis symptoms, such as bone density increase of mouse femur, increase of bone trabecula thickness and quantity, increase of cortical bone thickness and area, and reduction of osteoporosis. Therefore, the gRNA sequence can be used for constructing the osteosclerosis animal model.

The present invention relates to a probiotic agent for promoting height development containing Lactobacillus casei LC89 strain and its application. Lactobacillus cheese LC89 strain and Bifidobacterium longum subsp. infantis Bifidobacterium longum subsp.infantis The probiotics are composed of BI03 strains. In terms of growth and development indicators, they can significantly increase the weight and length of mice; in terms of bone development indicators, they can significantly increase the bone density and bone length of mice; in terms of biochemical indicators, they can significantly increase the levels of growth hormone and insulin-like growth factor-1 in mice.

The invention discloses a traditional Chinese medicine preparation for treating osteoporosis and a preparation method, and relates to the technical field of traditional Chinese medicine preparations, and the traditional Chinese medicine preparation is prepared from the following components: sargentgloryvine stem, fructus kochiae, caulis spatholobi, liquorice, poria cocos, semen cuscutae, salvia chinensis, a salvia miltiorrhiza compound, radix paeoniae alba, codonopsis pilosula, semen armeniacae amarae, cinnamon and corn starch. The prepared traditional Chinese medicine preparation is mainly used for treating osteoporosis symptoms, and the effects of promoting osteoblast development, improving bone mineral density and relieving the osteoporosis symptoms are achieved by means of cooperation of all the components, cooperation of multiple active ingredients and regulation and control of expression of some signal channels.

The invention relates to a composition with a function of improving bone mineral density, application of the composition and a preparation method of related health-care products or foods, and the composition comprises the following components in parts by weight: 0.5-4.5 parts of D-glucosamine hydrochloride, 0.5-3 parts of calcium carbonate, 0.1-1.5 parts of sodium chondroitin sulfate, 0.5-2.5 parts of American ginseng extract, 0.2-2 parts of salvia miltiorrhiza extract, 0.15-1.5 parts of radix paeoniae alba extract and 0.1-1 part of turmeric extract. The composition is prepared into a medicine, a health care product or a food to increase the bone mineral density. According to the composition, green, natural and high-quality raw materials and auxiliary materials are selected, the composition is prepared from the perspective of traditional Chinese medicine, modern nutriology and modern pharmacology, calcium supplement, articular cartilage protection and inflammation relieving are integrated, the formula plays a comprehensive role in increasing the bone mineral density in different links, and the effect of increasing the bone mineral density under the effect of three pipes is achieved. The composition can be prepared into medicines, health-care products or foods, the preparation process is simple, and the prepared product is green, safe and remarkable in curative effect and has a good market prospect.

The invention relates to the technical field of biological medicines and functional nucleic acid molecules, and discloses pearl mussel source miRNA and application thereof, a biological preparation and application thereof. The pearl mussel source miRNA is miRNA derived from a pearl mussel pallium exosome, contains a sequence shown in SEQ ID NO: 1, and can be modified by phosphorylation, locked nucleic acid and the like to enhance the stability. The biological preparation containing the miRNA can be used for preparing a medicine for preventing and / or treating osteoporosis or functional food for promoting bone mineralization, and the bone mineral density and the bone microstructure are improved by promoting osteoblast proliferation, differentiation and mineralization. According to the invention, marine biological resources which are natural in source and high in safety are utilized, and new active ingredients and technical schemes are provided for prevention and treatment of osteoporosis.

The invention relates to the field of health food, in particular to a composition for preventing osteoporosis. The invention discloses a composition for preventing osteoporosis. Comprising the following components in parts by weight: 30-40 parts of glucosamine sulfate, 13-40 parts of calcium carbonate, 15-20 parts of sodium chondroitin sulfate and 10-30 parts of collagen, and the collagen comprises type I collagen and type II collagen. Various kinds of collagen are screened and added into the composition, and after the collagen type I and the collagen type II are added at the same time, the composition can remarkably promote bone cell growth and enhance calcium absorption, so that the composition is beneficial to increase of bone mineral density and prevention of osteoporosis. Meanwhile, the sturgeon cartilage is screened and used as the II-type collagen source, so that the effect is more remarkable.

The invention belongs to the field of food, and specifically relates to a composition containing bovine bone collagen peptide and a preparation method thereof. The components of the composition include bovine cartilage collagen peptide chelate, a complex of yak bone collagen peptide and chitosan oligosaccharide, enzymatic bone powder, cartilage extract, sucralose, and oligomaltose, and the composition is prepared by mixing the components. The bovine bone collagen peptide composition of the invention has a fresh smell, high market acceptance, high storage stability, strong gastric acid or enzyme resistance, strong stability, high bioavailability, and low-cost and readily available raw materials for preparation, and is easy to industrialize.

The invention belongs to the field of effects of traditional Chinese medicines in treatment of osteoporosis. The pathological change of osteoporosis is mainly bone microstructure injury, and comprises cortical bone thinning and porosity increase, bone trabecular connectivity loss, quantity reduction and gap increase, and bone reconstruction imbalance is the main reason of bone microstructure injury of osteoporosis patients. Adjustment of unbalanced bone metabolism and improvement of bone microstructure are key points in treatment. According to the technical scheme, the traditional Chinese medicine composition is preferably prepared from the following components in parts by weight: 1500 to 2500 parts of radix astragali seu hedysari, 300 to 600 parts of fructus schisandrae chinensis, 800 to 1200 parts of fructus lycii, 800 to 1200 parts of radix trichosanthis, 800 to 1200 parts of rhizoma anemarrhenae, 800 to 1200 parts of radix puerariae, 800 to 1200 parts of bulbus allii macrostemi, 500 to 700 parts of rhizoma acori graminei, 800 to 1200 parts of radix angelicae sinensis and 800 to 1200 parts of radix salviae miltiorrhizae. The traditional Chinese medicine composition disclosed by the invention can also be prepared into different dosage forms of medicines such as tablets, capsules, granules, oral liquid or injection together with pharmaceutically acceptable auxiliary materials.

The pedicle screw comprises a screw rod and a spherical head connected with the rear end of the screw rod, the interior of the screw rod is hollow, and a hole channel coaxial with the screw rod is formed; a first threaded section and a second threaded section are sequentially arranged outside the screw rod in the direction from the rear end to the front end of the screw rod; the thread pitch of the first thread section is smaller than that of the second thread section; and a plurality of side wall concave holes communicated with the pore passages are formed in the side wall of the screw rod between adjacent threads of the second thread section and are used for enabling bone debris to enter the pore passages. According to the spinal column screw, the side wall concave hole is formed, so that when the screw is screwed into a spinal column, bone chippings can be automatically drawn into the hole channel, the bone chippings and bones loaded in the hole channel form protein contact, bone growth is further promoted, and the problem that the screw is loosened for a patient after a spinal column operation is solved.

This invention discloses a neutral homogeneous polysaccharide from Rehmannia glutinosa, its preparation method, and its applications, belonging to the field of traditional Chinese medicine preparation technology. The polysaccharide is mainly composed of galactose, glucose, and fructose in a molar ratio of 2.72:1.17:1.11, with a weight-average molecular weight of 2152 Da. The neutral polysaccharide from Rehmannia glutinosa can exert a therapeutic effect on osteoporosis by increasing bone mineralization and bone density; it can also promote the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), showing significant application effects in the preparation of stem cell therapy drugs for bone defects. The neutral homogeneous polysaccharide from Rehmannia glutinosa shows great application potential in the preparation of drugs for treating osteoporosis and as a stem cell therapy (especially bone regeneration therapy based on bone marrow mesenchymal stem cells). This provides new candidate substances and research directions for developing efficient and safe treatment strategies for bone metabolic diseases derived from traditional Chinese medicine.

The invention provides traditional Chinese medicine bone-strengthening granules and relates to the field of traditional Chinese medicine granules. The traditional Chinese medicine bone-strengthening granules are specifically prepared from the following raw materials in parts by weight: 60-80 parts of deer blood, 50-70 parts of agkistrodon halys, 110-200 parts of papaya, 5-20 parts of clove, 3-15 parts of liquorice, 10-30 parts of red dates, 5-10 parts of lemon, 6-8 parts of stevioside and a proper amount of milk mineral salt. The bone-strengthening granules are prepared by freeze-drying, concentrating and granulating authentic medicinal materials, and the bone-strengthening granules are prepared by selecting a plurality of medicinal and edible traditional Chinese medicinal materials and extracting through scientific compatibility and a special process, so that the bone-strengthening granules aim to help to improve the health condition of bones, enhance the strength of the bones and reduce the risk of various bone diseases such as osteoporosis.

The invention relates to the technical field of food beverages, in particular to a formula and a preparation process of a hydrolyzed protein liquid beverage, the formula of the hydrolyzed protein liquid beverage comprises protein, a supplement and a conditioning agent, the supplement is selected from one or more of calcium hydroxybutyrate, leucine, isoleucine and valine, and the conditioning agent is selected from one or more of calcium hydroxybutyrate, leucine, isoleucine and valine. The regulator is selected from one or more of gamma-aminobutyric acid, glycine, taurine, 5-hydroxytryptamine and beta-aminobutyric acid; peptide molecules contained in the hydrolyzed protein liquid beverage disclosed by the invention can quickly enter blood circulation through intestinal tracts; for a patient in a hypoproteinemia state before and after an operation, rapid and effective protein supplement is crucial, postoperative recovery is promoted, and the occurrence rate of complications is reduced; for traumatic injuries such as fracture, burn and the like, timely supplement of high-quality protein components is a key for accelerating wound healing and tissue repair.

This invention relates to the field of dandelion total flavonoids application technology, and discloses the application of dandelion total flavonoids in the preparation of products for the prevention and treatment of osteoporosis. The extraction method of dandelion total flavonoids according to this invention includes the following steps: 1) drying and pulverizing the whole dandelion plant to obtain dandelion powder; 2) mixing the dandelion powder with 60% ethanol (volume fraction), ultrasonically treating, and then filtering; 3) mixing the filtered residue with 40% ethanol (volume fraction), heating and refluxing, and then filtering; 4) combining the filtrates, concentrating, and drying to obtain dandelion total flavonoids. This invention, through biological and cellular level studies, has found that dandelion total flavonoids can effectively improve bone density and bone quality; therefore, dandelion total flavonoids can be applied to products for the prevention and treatment of osteoporosis.

The application provides application of a composition containing butyric acid-producing bacteria and vitamin K2 in preparation of a drug for treating osteoporosis, relates to the technical field of biological medicine, and the composition comprises: butyric acid-producing bacteria and vitamin K2; wherein the butyric acid-producing bacteria are selected from any one or more of clostridium butyricum, roseburia or faecalibacterium prausnitzii; and the vitamin K2 is selected from any one or more of menadione-4 or menadione-7. The composition can exert a synergistic effect through the "gut-bone axis", and can more significantly improve bone density compared with single components. The composition has comprehensive effects and high safety, provides a brand-new, synergistic nutrition intervention strategy for the prevention and treatment of osteoporosis, and simultaneously provides a brand-new possibility for the preparation of drugs related to osteoporosis.

The invention provides a composition for preventing bone loss caused by cold exposure as well as a preparation method and application of the composition, and belongs to the technical field of pharmaceutical compositions. The composition provided by the invention is prepared from the following components in parts by weight: 1.18 to 1.58 parts of radix angelicae sinensis extract, 1.18 to 1.58 parts of flos carthami extract, 1.18 to 1.58 parts of semen persicae extract and 2.56 to 2.96 parts of fructus crataegi extract. The preparation method of the composition comprises the following steps: weighing the polymer carrier, adding the polymer carrier into precooled purified water, and adding ethanol; weighing a raw material mixture, and adding the raw material mixture into the polymer solution; performing spray drying to obtain fine powder, and performing vacuum drying to obtain the composition for preventing bone loss caused by cold exposure. The composition for preventing bone loss caused by cold exposure, prepared by the invention, has high solubility and high dissolution rate, and active ingredients take effect quickly; the bone loss caused by cold exposure can be prevented.

According to the application of the mulberry extract in preparing the medicine for treating and / or preventing the diseases related to the abnormal bone metabolism, the mulberry extract comprises alkaloid with the weight content being 3% or above, and / or polysaccharide with the weight content being not higher than 70%, and / or flavone with the weight content being not higher than 10%, and / or amino acid with the weight content being not higher than 50%, and / or other components. The mulberry extract disclosed by the invention has a remarkable improvement effect on diseases related to abnormal bone metabolism.

The present invention belongs to the technical field of sea cucumber intestines and sea cucumber intestinal peptide applications, and specifically relates to a sea cucumber intestinal peptide and its application in the preparation of anti-osteoporosis products. The present invention obtains sea cucumber intestinal peptides by enzymatic hydrolysis with commercial proteases, and then achieves the purpose of removing fishy smell by microbial fermentation. The dual treatment of enzymatic hydrolysis and fermentation makes the sea cucumber intestinal peptides have higher biological activity, and obtains 10 peptide segments with the best effect, which can be used in the preparation of anti-osteoporosis products.