80 results about "Dysplasia" patented technology

The present invention relates to FGFR3 inhibitor compounds of novel structure or pharmaceutically acceptable salts, isotope variants, tautomers, stereoisomers or prodrugs thereof, and their use as medicine. The compounds are useful in the treatment of cancers such as urothelial carcinoma, systemic sclerosis, fibrosis, pulmonary fibrosis, cartilage insufficiency, lethal insufficiency, severe cartilage insufficiency accompanied by developmental retardation and atrachis ossicular, or muenke syndrome. # imgabs0 #

The invention relates to compositions containing selenite-containing compounds and pharmaceutically acceptable acids, selected from citric acid, acetic acid, malic acid, carbonic acid, sulphuric acid, nitric acid, hydrochloric acid, fruit acids or mixtures thereof, for use for treating cervical inflammations, dysplasia and / or carcinomas. The invention further relates to methods of using such compositions.

Provided herein are methods for diagnosing and treating a pulmonary disease, e.g., bronchopulmonary dysplasia (BPD) using proteomics analysis.

The present invention provides methods and compositions for the treatment of chronic lung disease (CLD), comprising administering to a subject in need of treatment a composition comprising insulin-like growth factor-1 (IGF-1).

The present application relates to a method for extracting an acetabular facies lunata model, in particular to a method for extracting an acetabular facies lunata model based on mixed surface fitting, which solves the technical problem of low precision and robustness of the existing method for extracting an acetabular facies lunata model. The present application realizes rough extraction of the acetabular facies lunata model through spherical surface fitting, and then realizes accurate extraction of the acetabular facies lunata model in combination with ellipsoidal surface fitting, which combines the stability of spherical surface fitting and the anatomical fidelity of ellipsoidal surface fitting. In particular, in the case of complex pathologies such as hip dysplasia, the present application can still maintain high extraction accuracy, and improve the accuracy and reliability of clinical diagnosis and surgical planning. Meanwhile, in the iteration process of ellipsoidal surface fitting, an adaptive fault tolerance threshold is introduced, which effectively solves the problems of sensitivity to noise and strong parameter dependence of traditional methods, and has better robustness in processing complex acetabular morphology.

The invention discloses a bronchial lung dysplasia severity prediction method and related equipment, and belongs to the technical field of machine learning, and the method comprises the steps: obtaining the clinical data of a target object; preprocessing the clinical data of the target object, constructing a training set and a verification set according to a preset proportion, and screening to obtain a target variable; based on the target variable, constructing a plurality of bronchial lung dysplasia severity prediction models by using the training set, and performing model performance evaluation on the plurality of constructed bronchial lung dysplasia severity prediction models in the verification set; and obtaining a bronchial lung dysplasia severity prediction model with the optimal performance so as to complete bronchial lung dysplasia severity prediction. The clinical data of the target object is combined with the machine learning algorithm, so that the dynamic change of the immune system of the premature infant can be reflected more comprehensively, the prediction accuracy of the severity of early bronchial pulmonary dysplasia is improved, and scientific data support is provided for clinical treatment selection.

The present disclosure provides compositions and methods for distinguishing between non-cancerous, pre-cancerous, and cancerous conditions in the esophagus. In particular, the present disclosure provides compositions and methods for distinguishing non-dysplastic Barrett's esophagus (NDBE) samples from pre-cancerous (e.g., low-grade or high-grade dysplasia) and / or cancerous (e.g., esophageal adenocarcinoma) samples based on methylation status and / or DNA copy number abnormalities.

This invention relates to a nutritional composition for promoting bone development and its applications. The invention provides applications of the nutritional composition or preparations comprising said nutritional composition, including: (1) preparing food products; (2) preparing health products for promoting bone development, increasing height, and / or improving bone density; (3) preparing drugs or drug compositions for promoting bone development, increasing height, increasing bone density, treating or preventing osteoporosis, and / or treating or preventing skeletal dysplasia; and (4) promoting bone development, increasing height, and / or improving bone density for non-therapeutic purposes; wherein said nutritional composition comprises medium- and long-chain triglycerides (MLCT) and 1,3-diunsaturated fatty acid-2-palmitoyltriglycerides (UPU).

The present disclosure provides methods, uses, and pharmaceutical compositions with utility in the treatment of acute lung injuries or chronic lung diseases including, bronchopulmonary dysplasia and exacerbations of bronchopulmonary dysplasia.

The present invention relates to a CNP or CNP conjugate or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising such CNP or CNP conjugate or a pharmaceutically acceptable salt thereof for use in the treatment of a lower extremity deformity in a subject with a skeletal dysplasia and wherein the subject has or is at risk of developing said lower extremity deformity and related aspects.

Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).

The invention belongs to the technical field of biological medicine, and particularly relates to a serum exosome circular RNA marker and application thereof. The invention relates to a serum exosome circular RNA (Ribonucleic Acid) marker for diagnosing or predicting bronchial lung dysplasia of a premature infant. The circular RNA marker is selected from at least one of the following components: hsacirc0001522; the molecular marker is Hsacirc0001359. By finding differentially expressed cyclic rna in serum exosomes of BPD infants and non-BPD infants on the 7th day, the 14th day and the 28th day, cyclic rna is differentially expressed in the serum exosomes of the BPD infants and the non-BPD infants. The invention relates to the field of biomarkers, in particular to hsacirc0001359, which can be used as a very promising and easily available biomarker and can be used for predicting BPD on the seventh day after birth.

The invention relates to a computer-implemented method for detecting oesophageal squamous cell dysplasia (OSCD) or oesophageal squamous cell cancer (OSCC) in a cell sample from a subject. This invention also relates to a computer-implemented method for generating a trained model to detect OSCD or OSCC. This invention also relates to a computer-readable storage medium or a computer program comprising instructions which when executed by a computer, are capable of causing the computer to perform the method. This invention also relates to a kit comprising the computer program or computer-readable storage medium and a non-endoscopic cell collection device. The invention also relates to an apparatus for performing the method. The invention further relates to the use of genome wide instability scores (GWIS) as a diagnostic marker for cancer, wherein GWIS is a measure of the CNV across a plurality of autosomal arms in a cell sample from a subject.

The invention provides a computer-implemented method for assisting diagnosis of dysplasia from a liquid-based cytology whole-slide image (WSI), using a multi-stage pipeline combining deep- learning-based detection with engineered feature extraction and a calibrated machine-learning classifier. The method involves receiving and resampling a digital WSI to a canonical spatial resolution, detecting individual cell instances with a neural network, computing morphological and texture features for each detected cell, aggregating these features across the WSI to form a slide-level feature vector, inputting this vector into a calibrated classifier to yield a slide-level probability of dysplasia, computing slide-quality metrics to govern downstream triage, presenting results via an interactive graphical interface with per-cell thumbnails, and iteratively refining the system with expanded and harmonized training data from expert annotations.

The invention belongs to the technical field of gene engineering, and particularly relates to a construction method of a ribosomal disease zebrafish model. The invention provides a construction method of a ribosomal disease zebrafish model, which comprises the following steps: directionally mutating a pno1 gene in a wild zebrafish embryo to obtain F0-generation zebrafish; mating the F0-generation zebrafish with wild type zebrafish, and screening out positive heterozygote F1-generation zebrafish from birth zebrafish as the ribosomal disease zebrafish model. The zebrafish mutant is constructed through the targeted ribosomal factor gene, multi-system phenotypes of hematopoietic system defects, skeletal insufficiency and digestive system dysplasia can be reproduced at the same time, the problem that in the prior art, disease phenotypes are incomplete is solved, and the zebrafish mutant can be widely applied to pathogenesis research and drug screening of ribosomal diseases and has a wide application prospect. An important platform is provided for developing a novel treatment means.

The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of esophageal tissue and gastric tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic Barrett's Esophagus stem cells (BESCs) or Gastric Intestinal Metaplasia stem cells (GIMSCs) relative to normal regenerative esophageal stem cells or gastric stem cells in the tissue in which the BESCs or GIMSCs are found.

The invention relates to the technical field of child hip joint development prediction, in particular to a child hip joint development prediction method and device.In the embodiment of the invention, firstly, a hip joint two-dimensional ultrasonic image is input into a first prediction model, and the normal distribution probability and the prediction value of the child hip joint development week age number are predicted; a hip three-dimensional model is constructed through the hip joint two-dimensional ultrasonic image, and three groups of acetabulum dysplasia evaluation factors in three dimensions are obtained based on the hip three-dimensional model; and finally, integrating the children clinical information, the children hip joint development week age prediction result and the acetabular dysplasia evaluation factor to obtain a prediction result of the children hip joint development condition.

The present invention relates to a method for promoting wound healing in a subject suffering from Ectodermal dysplasia in need thereof comprising a step of administering subcutaneously, intradermally or topically to said subject a therapeutically effective amount of a compound which restores the activity of p63. Inventors have performed a primary culture of patient keratinocytes suffering from ectodermal dysplasias with two compounds which restore the activity of p63 (e.g. STIMA-1 and / or PRIMA-1Met). They have shown that there is an important differentiation of the keratinocytes of said patient compared to the cells not treated with these compounds. They observed that the activity of p63 mutated is restored, thus the proliferation and differentiation of keratinocytes from the patient are activated. Moreover, inventors have used PRIMA-1Met by topical application on a young patient suffering from ectodermal dysplasias and shown that said patient presents an improvement on her hand. Typically, severe skin erosions (on hands and feet) are healing when PRIMA-1Met is administered topically on the hand.

The present invention relates to detecting esophageal diseases. Provided herein are techniques for screening for esophageal diseases, particularly but not exclusively, methods, compositions, and related uses for detecting the presence of esophageal diseases (e.g., Barrett's esophagus, Barrett's esophagus dysplasia, etc.). In addition, the present technology provides methods, compositions, and related uses for distinguishing between Barrett's esophagus and Barrett's esophagus dysplasia, as well as low-grade dysplasia, high-grade dysplasia, and esophageal adenocarcinoma in samples obtained by endoscopic brushing or non-endoscopic whole esophageal brushing or swabbing using a tethered device (e.g., a capsule sponge, balloon, or other device).

The invention discloses a hip joint cartilage non-uniform multi-section feature three-dimensional reconstruction method, and belongs to the field of medical image three-dimensional digital modeling and orthopedic biomechanical technology research. According to the method, hip joint dysplasia is taken as a research object, and boundary segmentation and reconstruction of a three-dimensional geometric model of bone tissue are carried out through CT (Computed Tomography); based on a nuclear magnetic resonance image and an anatomical structure, computer-aided software and a curve fitting method are utilized to reconstruct a high-precision hip joint cartilage three-dimensional geometric model with inner and outer contours and non-uniform thickness, and finally a hip joint-cartilage three-dimensional model is constructed in an origin registration mode. According to the method, the multi-section feature three-dimensional model of the hip joint cartilage can be accurately and efficiently reconstructed, irregular curved surfaces of the cartilage reconstruction model are effectively reduced, and finite element mesh division and surface contact calculation of the hip joint are facilitated; and a high-precision cartilage three-dimensional digital model reference is provided for clinical diagnosis and treatment, rehabilitation, prosthesis design and biomechanical analysis of hip joint diseases.

Methods for preventing and / or treating a chronic lung disease, e.g., bronchopulmonary dysplasia, in preterm infants using vamorolone are provided herein. Vamorolone reduces symptoms of bronchopulmonary dysplasia and yields reduced risk for adverse effects that are associated with other corticosteroids. The presently disclosed subject matter further relates to pharmaceutical compositions, e.g., aerosolized compositions, for administering vamorolone to preterm infants.

Provided herein are multi-chain chimeric polypeptides and use thereof in treating bronchopulmonary dysplasia in a subject.

The invention discloses a ribonucleoprotein complex and a construction method of a hand / foot division deformity IV-type animal model, and belongs to the technical field of genetic engineering. According to the mouse model, exons 7 and 8 of the mouse genome Trp63 gene are knocked out, then a sequence is introduced, the 956th basic group is mutated from a G basic group to an A basic group, and the mouse model with the hand / foot division deformity IV is constructed, compared with an existing Trp63 gene knockout mouse model, the mouse model can better simulate the disease, and a foundation is laid for researching the pathogenic mechanism of the disease. A new method is provided for research of limb dysplasia diseases and screening of treatment drugs, and the method has a good application prospect.

The present invention relates to a combination of markers for detecting human papillomavirus (HPV) in a cervical sample, wherein said combination of markers comprises a first marker selected from MUC5B and / or TFF3 for verifying the reliability of the cervical sample, wherein the expression of the first marker indicates that the cervical sample comprises cells from the cervical transition zone and / or endocervical canal; and a second marker for detecting HPV. Further, the present invention relates to a method for verifying the reliability of a biological sample, as well as a method for detecting HPV in a biological sample, based on the analysis of the one or more markers selected from MUC5B and / or TFF3. Also provided is the use of the novel markers of the invention for verifying the reliability of a biological sample. Furthermore, provided are methods for screening of sexually transmitted infections (STI) and of dysplastic / neoplastic lesions in a biological sample. The present invention also provides a kit of parts for the above-mentioned methods.

Photodynamic therapy device and system comprising one or more light sources configured to produce one or more wavelengths of light, a component configured to control the one or more light sources, and a treatment probe including a light guide implemented on a distal end, wherein the light guide is configured to direct the one or more wavelengths of light onto the cervix, and methods for using the device and system to induce regression of mucosal dysplasia are provided.

The invention relates to the detection of esophageal disease. Provided herein are techniques for esophageal disease screening, in particular, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal diseases (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). Furthermore, the present technology provides for distinguishing Barrett's esophagus and Barrett's esophageal dysplasia, as well as Barrett's esophageal low dysplasia, in a sample obtained by endoscopic brushing or non-endoscopic total esophageal brushing or wiping using a mooring device (e.g., a capsule sponge, balloon, or other device), methods, compositions and related uses for Barrett's esophageal dysplasia and esophageal adenocarcinoma.

The application provides a femoral stem prosthesis for severe hip dysplasia, which comprises a first section and a second section which are integrally formed and distributed along the up-down direction, the first section is used for penetrating and press-fitting in the proximal segment of the femur, and the second section is used for inserting and press-fitting in the distal segment of the femur. The first section and the second section adopt a tapered structure, which can improve the axial stability, and the rotation-stopping structure outside the first section and the second section can limit the relative rotation of the prosthesis and the femur. The second section of the femoral stem prosthesis can select a suitable size according to the actual situation of the femur of the patient, so as to improve the stability of the connection, when the second section is stably connected with the distal segment of the femur, the proximal segment of the femur is press-fitted with the first section, and finally the femoral stem prosthesis is continuously pressed, so that the cross section of the distal segment of the femur and the proximal segment of the femur is in contact and sufficient pressing force is provided.

The invention relates to the technical field of biological medicine, in particular to placenta-derived tRF and application of the placenta-derived tRF in prevention and treatment of bronchial lung dysplasia, the placenta-derived tRF is a derivative fragment generated after glycine tRNA is modified by pseudouridine, and the nucleotide sequence of the placenta-derived tRF is shown as SEQ ID No.1. The invention innovatively finds that the placenta-derived tRNAGly derivative fragment tRF-0009 is an important active metabolite for mediating placenta and alveolar development, can inhibit mitochondrial integration stress reaction, negatively regulate AECII proliferation and differentiation, and perform deep function and mechanism exploration on tRF-0009, and can provide a potential strategy and a new target for prevention and treatment of BPD.

Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue. When the tissue framework is left intact, the framework structure repopulates with healthy cells, regenerating the normal tissue without altering the structural properties.

Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue. When the tissue framework is left intact, the framework structure repopulates with healthy cells, regenerating the normal tissue without altering the structural properties.