54 results about "Dysplasia" patented technology

The invention relates to compositions containing selenite-containing compounds and pharmaceutically acceptable acids, selected from citric acid, acetic acid, malic acid, carbonic acid, sulphuric acid, nitric acid, hydrochloric acid, fruit acids or mixtures thereof, for use for treating cervical inflammations, dysplasia and / or carcinomas. The invention further relates to methods of using such compositions.

The present invention provides methods and compositions for the treatment of chronic lung disease (CLD), comprising administering to a subject in need of treatment a composition comprising insulin-like growth factor-1 (IGF-1).

The present application relates to a method for extracting an acetabular facies lunata model, in particular to a method for extracting an acetabular facies lunata model based on mixed surface fitting, which solves the technical problem of low precision and robustness of the existing method for extracting an acetabular facies lunata model. The present application realizes rough extraction of the acetabular facies lunata model through spherical surface fitting, and then realizes accurate extraction of the acetabular facies lunata model in combination with ellipsoidal surface fitting, which combines the stability of spherical surface fitting and the anatomical fidelity of ellipsoidal surface fitting. In particular, in the case of complex pathologies such as hip dysplasia, the present application can still maintain high extraction accuracy, and improve the accuracy and reliability of clinical diagnosis and surgical planning. Meanwhile, in the iteration process of ellipsoidal surface fitting, an adaptive fault tolerance threshold is introduced, which effectively solves the problems of sensitivity to noise and strong parameter dependence of traditional methods, and has better robustness in processing complex acetabular morphology.

The invention discloses a bronchial lung dysplasia severity prediction method and related equipment, and belongs to the technical field of machine learning, and the method comprises the steps: obtaining the clinical data of a target object; preprocessing the clinical data of the target object, constructing a training set and a verification set according to a preset proportion, and screening to obtain a target variable; based on the target variable, constructing a plurality of bronchial lung dysplasia severity prediction models by using the training set, and performing model performance evaluation on the plurality of constructed bronchial lung dysplasia severity prediction models in the verification set; and obtaining a bronchial lung dysplasia severity prediction model with the optimal performance so as to complete bronchial lung dysplasia severity prediction. The clinical data of the target object is combined with the machine learning algorithm, so that the dynamic change of the immune system of the premature infant can be reflected more comprehensively, the prediction accuracy of the severity of early bronchial pulmonary dysplasia is improved, and scientific data support is provided for clinical treatment selection.

The present disclosure provides compositions and methods for distinguishing between non-cancerous, pre-cancerous, and cancerous conditions in the esophagus. In particular, the present disclosure provides compositions and methods for distinguishing non-dysplastic Barrett's esophagus (NDBE) samples from pre-cancerous (e.g., low-grade or high-grade dysplasia) and / or cancerous (e.g., esophageal adenocarcinoma) samples based on methylation status and / or DNA copy number abnormalities.

This invention relates to a nutritional composition for promoting bone development and its applications. The invention provides applications of the nutritional composition or preparations comprising said nutritional composition, including: (1) preparing food products; (2) preparing health products for promoting bone development, increasing height, and / or improving bone density; (3) preparing drugs or drug compositions for promoting bone development, increasing height, increasing bone density, treating or preventing osteoporosis, and / or treating or preventing skeletal dysplasia; and (4) promoting bone development, increasing height, and / or improving bone density for non-therapeutic purposes; wherein said nutritional composition comprises medium- and long-chain triglycerides (MLCT) and 1,3-diunsaturated fatty acid-2-palmitoyltriglycerides (UPU).

The present disclosure provides methods, uses, and pharmaceutical compositions with utility in the treatment of acute lung injuries or chronic lung diseases including, bronchopulmonary dysplasia and exacerbations of bronchopulmonary dysplasia.

The present invention relates to a CNP or CNP conjugate or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising such CNP or CNP conjugate or a pharmaceutically acceptable salt thereof for use in the treatment of a lower extremity deformity in a subject with a skeletal dysplasia and wherein the subject has or is at risk of developing said lower extremity deformity and related aspects.

The invention belongs to the technical field of biological medicine, and particularly relates to a serum exosome circular RNA marker and application thereof. The invention relates to a serum exosome circular RNA (Ribonucleic Acid) marker for diagnosing or predicting bronchial lung dysplasia of a premature infant. The circular RNA marker is selected from at least one of the following components: hsacirc0001522; the molecular marker is Hsacirc0001359. By finding differentially expressed cyclic rna in serum exosomes of BPD infants and non-BPD infants on the 7th day, the 14th day and the 28th day, cyclic rna is differentially expressed in the serum exosomes of the BPD infants and the non-BPD infants. The invention relates to the field of biomarkers, in particular to hsacirc0001359, which can be used as a very promising and easily available biomarker and can be used for predicting BPD on the seventh day after birth.

The invention relates to a computer-implemented method for detecting oesophageal squamous cell dysplasia (OSCD) or oesophageal squamous cell cancer (OSCC) in a cell sample from a subject. This invention also relates to a computer-implemented method for generating a trained model to detect OSCD or OSCC. This invention also relates to a computer-readable storage medium or a computer program comprising instructions which when executed by a computer, are capable of causing the computer to perform the method. This invention also relates to a kit comprising the computer program or computer-readable storage medium and a non-endoscopic cell collection device. The invention also relates to an apparatus for performing the method. The invention further relates to the use of genome wide instability scores (GWIS) as a diagnostic marker for cancer, wherein GWIS is a measure of the CNV across a plurality of autosomal arms in a cell sample from a subject.

The invention provides a computer-implemented method for assisting diagnosis of dysplasia from a liquid-based cytology whole-slide image (WSI), using a multi-stage pipeline combining deep- learning-based detection with engineered feature extraction and a calibrated machine-learning classifier. The method involves receiving and resampling a digital WSI to a canonical spatial resolution, detecting individual cell instances with a neural network, computing morphological and texture features for each detected cell, aggregating these features across the WSI to form a slide-level feature vector, inputting this vector into a calibrated classifier to yield a slide-level probability of dysplasia, computing slide-quality metrics to govern downstream triage, presenting results via an interactive graphical interface with per-cell thumbnails, and iteratively refining the system with expanded and harmonized training data from expert annotations.

The invention belongs to the technical field of gene engineering, and particularly relates to a construction method of a ribosomal disease zebrafish model. The invention provides a construction method of a ribosomal disease zebrafish model, which comprises the following steps: directionally mutating a pno1 gene in a wild zebrafish embryo to obtain F0-generation zebrafish; mating the F0-generation zebrafish with wild type zebrafish, and screening out positive heterozygote F1-generation zebrafish from birth zebrafish as the ribosomal disease zebrafish model. The zebrafish mutant is constructed through the targeted ribosomal factor gene, multi-system phenotypes of hematopoietic system defects, skeletal insufficiency and digestive system dysplasia can be reproduced at the same time, the problem that in the prior art, disease phenotypes are incomplete is solved, and the zebrafish mutant can be widely applied to pathogenesis research and drug screening of ribosomal diseases and has a wide application prospect. An important platform is provided for developing a novel treatment means.

The present invention relates to a method for promoting wound healing in a subject suffering from Ectodermal dysplasia in need thereof comprising a step of administering subcutaneously, intradermally or topically to said subject a therapeutically effective amount of a compound which restores the activity of p63. Inventors have performed a primary culture of patient keratinocytes suffering from ectodermal dysplasias with two compounds which restore the activity of p63 (e.g. STIMA-1 and / or PRIMA-1Met). They have shown that there is an important differentiation of the keratinocytes of said patient compared to the cells not treated with these compounds. They observed that the activity of p63 mutated is restored, thus the proliferation and differentiation of keratinocytes from the patient are activated. Moreover, inventors have used PRIMA-1Met by topical application on a young patient suffering from ectodermal dysplasias and shown that said patient presents an improvement on her hand. Typically, severe skin erosions (on hands and feet) are healing when PRIMA-1Met is administered topically on the hand.

The invention discloses a ribonucleoprotein complex and a construction method of a hand / foot division deformity IV-type animal model, and belongs to the technical field of genetic engineering. According to the mouse model, exons 7 and 8 of the mouse genome Trp63 gene are knocked out, then a sequence is introduced, the 956th basic group is mutated from a G basic group to an A basic group, and the mouse model with the hand / foot division deformity IV is constructed, compared with an existing Trp63 gene knockout mouse model, the mouse model can better simulate the disease, and a foundation is laid for researching the pathogenic mechanism of the disease. A new method is provided for research of limb dysplasia diseases and screening of treatment drugs, and the method has a good application prospect.

The present invention relates to a combination of markers for detecting human papillomavirus (HPV) in a cervical sample, wherein said combination of markers comprises a first marker selected from MUC5B and / or TFF3 for verifying the reliability of the cervical sample, wherein the expression of the first marker indicates that the cervical sample comprises cells from the cervical transition zone and / or endocervical canal; and a second marker for detecting HPV. Further, the present invention relates to a method for verifying the reliability of a biological sample, as well as a method for detecting HPV in a biological sample, based on the analysis of the one or more markers selected from MUC5B and / or TFF3. Also provided is the use of the novel markers of the invention for verifying the reliability of a biological sample. Furthermore, provided are methods for screening of sexually transmitted infections (STI) and of dysplastic / neoplastic lesions in a biological sample. The present invention also provides a kit of parts for the above-mentioned methods.

The invention relates to the detection of esophageal disease. Provided herein are techniques for esophageal disease screening, in particular, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal diseases (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). Furthermore, the present technology provides for distinguishing Barrett's esophagus and Barrett's esophageal dysplasia, as well as Barrett's esophageal low dysplasia, in a sample obtained by endoscopic brushing or non-endoscopic total esophageal brushing or wiping using a mooring device (e.g., a capsule sponge, balloon, or other device), methods, compositions and related uses for Barrett's esophageal dysplasia and esophageal adenocarcinoma.

The application provides a femoral stem prosthesis for severe hip dysplasia, which comprises a first section and a second section which are integrally formed and distributed along the up-down direction, the first section is used for penetrating and press-fitting in the proximal segment of the femur, and the second section is used for inserting and press-fitting in the distal segment of the femur. The first section and the second section adopt a tapered structure, which can improve the axial stability, and the rotation-stopping structure outside the first section and the second section can limit the relative rotation of the prosthesis and the femur. The second section of the femoral stem prosthesis can select a suitable size according to the actual situation of the femur of the patient, so as to improve the stability of the connection, when the second section is stably connected with the distal segment of the femur, the proximal segment of the femur is press-fitted with the first section, and finally the femoral stem prosthesis is continuously pressed, so that the cross section of the distal segment of the femur and the proximal segment of the femur is in contact and sufficient pressing force is provided.

Devices, systems and methods are provided for treating conditions of the reproductive tract. A number of conditions can afflict the lining and cell layers deeper within the anatomical structures. For example, cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is a condition involving abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer in situ (CIS). Other conditions include human papillomavirus (HPV)-related cervical disease, various endometrial diseases, acute and chronic cervicitis, and various infections (e.g. trichomoniasis) to name a few. In some embodiments, treatments eliminate diseased, damaged, abnormal or otherwise undesired cells leaving the tissue framework intact. This allows the tissue to regenerate in a normal fashion, avoiding the formation of scar tissue. When the tissue framework is left intact, the framework structure repopulates with healthy cells, regenerating the normal tissue without altering the structural properties.

The present inventions provide improved solution compositions and methods for detecting cancerous and dysplastic lesions in mucosal tissue in vivo. Specifically, the disclosed pretreatment solution results in enhanced removal of mucous and tissue debris. The disclosed detection solution compositions (nuclear stain-based and lectin-based) provide enhanced disease detection, when used individually or sequentially, tissue permeation, fluorescent signal, and shelf stability. Lectin fragmentation methods and processes of manufacturing are also disclosed. Additionally, various methods utilizes the disclosed inventive solution compositions are disclosed for accurate disease detection in vivo yielding high sensitivity and specificity values.

The invention belongs to the technical field of biological medicine, and particularly relates to application of a CCL20 / CCR6 axis in bronchial pulmonary dysplasia. According to the application of the targeted CCL20 / CCR6 shaft in the aspect of preparing the medicine for treating bronchial pulmonary dysplasia, it is proved that CCL20 can cause damage to the normal pulmonary development process of newborn mice; and the neutralizing antibody of CCL20 or the antagonist of CCR6 can effectively improve the pulmonary alveoli development retardation of the BPD mouse induced by high oxygen exposure. The invention provides a new thought for preparing the medicine for treating the BPD, and a method for better treating the BPD is realized by applying the targeted CCL20 / CCR6 to the development process of the medicine related to the BPD; meanwhile, the selection field of medicines for treating BPD is widened, and contributions are made to the development of the technical field.

The invention relates to the technical field of bone metabolism disease related markers, in particular to application of CASQ1 protein in preparation of bone metabolism related disease diagnosis and / or screening products. It is found that when the muscle function is abnormal or damaged, the content of CASQ1 protein in exosomes secreted by muscle cells is increased, the exosomes can be transferred to adjacent bone tissue, the osteogenic differentiation of bone marrow mesenchymal stem cells is inhibited, and then bone metabolism disorder is caused. The invention provides a diagnostic kit and a pharmaceutical composition taking CASQ1 protein as a detection target. The diagnostic kit and the pharmaceutical composition are used for early screening and diagnosis of bone metabolic diseases such as myogenic osteoporosis, fracture healing disorder and bone dysplasia. By detecting the content change of the CASQ1 protein in tissues or body fluids, quantitative evaluation of muscle dysfunction related bone metabolism abnormality can be realized, and a new detection means and a biological target are provided for clinical diagnosis and treatment intervention of related diseases.

The invention discloses a multi-subgroup hip joint dysplasia classification method and system, and belongs to the field of artificial intelligence. Comprising the following steps: acquiring a pelvis normal position X-ray film image of a patient, and preprocessing the image; a rough classification network is constructed, general features in the image are extracted to obtain a rough classification result for identifying the rough type of the dysplasia of the hip joint, and the general features comprise contours and textures; a fine classification network is constructed, on the basis of the graph convolution network, classification results are refined by additionally increasing expression information of anatomical key points on the basis of coarse classification results, and the anatomical key points comprise the highest point of the ilium, the outermost edge of the acetabulum, the center point of the femoral head, the teardrop point and the lowest point of the ischial tuberosity; and outputting a fine classification network result. According to the method, the system generalization can be improved while the classification efficiency and accuracy are improved.

The disclosure provides peptides, including labeled peptides, that selectively bind to the cMet protein. The disclosure also provides methods of detecting dysplastic cells and tissue, e.g., in the colon, providing early identification of precancerous and cancerous tissue.

The invention discloses a probe and method for probing a bony channel in sacroiliac screw implantation, and relates to the technical field of orthopedic surgical instruments, the probe comprises a hollow screw and a probe, the front end of the hollow screw is provided with a self-tapping part, the hollow screw is axially provided with a through hollow channel, and the hollow channel allows the probe to pass through; the probe comprises a rod body, a spherical head and a handle, and the spherical head is connected with the handle through the rod body. According to the hollow screw placement structure and method with the probe capable of feeding back the position of the bone channel in the sacrum, the spherical head of the probe can slide along the interior of the bone cortex of the sacrum after entering the sacrum, so that the situations that the bone channel of the hollow screw is irregular and narrow due to high-energy damage or sacrum dysplasia are prevented; therefore, the hollow screw penetrates out of the bone cortex, and serious nerve and blood vessel injury is caused. The probe technology not only can improve the operation safety and efficiency, but also can reduce the number of times of fluoroscopy in the operation.

This invention belongs to the field of nanoparticle hydrogel scaffold technology, providing an MMP-responsive nanoparticle hydrogel scaffold and its application in the treatment of fibrous bone dysplasia. The nanoparticle hydrogel scaffold is prepared by cross-linking and curing triglyceride monostearate nanoparticles, 3-aminophenylboronic acid-modified hyaluronic acid, and dopamine-modified hyaluronic acid. This invention is based on the first discovery that the concentration of matrix metalloproteinases (MMPs) around fibrous bone dysplasia lesions is a biomarker reflecting the "activity and treatment response of fibrous bone dysplasia lesions," and based on this discovery, provides an MMP-responsive nanoparticle hydrogel scaffold and its application in the treatment of fibrous bone dysplasia. This nanoparticle hydrogel scaffold can achieve perilesional drug delivery and sustained MMP-responsive drug release through injection, thereby providing a local treatment strategy for fibrous bone dysplasia.

The invention provides a telescopic intramedullary nail system, and belongs to the technical field of medical instruments. Comprising a front bone body, a rear bone body and a limiting mechanism, a fixing sleeve is slidably connected to the inner wall of a fixing groove, a sliding rod is slidably connected to the inner wall of the fixing sleeve, and a connecting sleeve is slidably connected to the inner wall of one end of the fixing sleeve; the device is characterized in that the inner wall of the fixing sleeve is provided with a limiting mechanism for preventing the sliding rod from moving backwards; along with the growth of the front bone body and the rear bone body, the overall length of the front bone body and the rear bone body can be changed, meanwhile, the sliding rod and the fixing sleeve slide relatively through the connecting sleeve, the overall length is increased, joint growth with the bone is achieved, and the sliding rod and the fixing sleeve placed in the front bone body and the rear bone body can form the effect of an intramedullary nail. The bone fracture stabilizer can be used for preventing or stabilizing bone fractures or correcting deformity of long bones in the growth process so that patients suffering from osteogenesis imperfecta, skeletal dysplasia and other skeletal deformity can use the bone fracture stabilizer conveniently.

1. Name of the design product: mandibular angle (PEEK polyether ether ketone). 2. Use of the design product: repair of mandibular bone mass defect and mandibular dysplasia. 3. Design points of the design product: in shape. 4. Picture or photo that best indicates the design points: kit 1 perspective view.

Described herein is the preferential knockdown of the mutant transcript ACVR1R206H and inhibition of osteogenic differentiation using allele-selective gapmers for the treatment of Fibrodysplasia Ossificans Progressiva.

The invention relates to an FGFR3 (fibroblast growth factor receptor 3) inhibitor as well as a composition and application thereof. The compound can be used for treating or preventing bladder cancer, lung cancer, stomach cancer, urothelial cancer, bile duct cancer, skeletal dysplasia, breast cancer, liver cancer, ovarian cancer, cervical cancer and other diseases. The structure of the compound is shown in the specification.

The invention relates to the technical field of biological medicines, and particularly discloses application of a product for promoting WBP11 gene expression in preparation of a medicine for treating or preventing bronchial pulmonary dysplasia. The product for promoting WBP11 gene expression promotes proliferation of human primary umbilical vein endothelial cells by promoting WBP11 gene expression, and promotes the tube forming ability of the human primary umbilical vein endothelial cells in bronchial pulmonary dysplasia.