31 results about "Bone development" patented technology

The invention relates to an application of plant lactobacillus Hi188 in promotion of bone health. The invention provides the application of the plant lactobacillus Hi188 or the afterbiogen thereof or the composition thereof in increasing the bone mineral density, increasing the bone mineral density, promoting the skeletal development, increasing the bone mineral content and / or promoting the tibia growth. Or preparing food for increasing bone mineral density, increasing bone mineral density, promoting skeletal development, increasing bone mineral content and / or promoting tibia growth; wherein the composition comprises: (A) Phytobacterium plantarum Hi188 or a postbiotic thereof, and (B) Bifidobacterium lactis Ca360 or a postbiotic thereof.

The utility model provides a bone anchorage type maxillary distraction osteogenesis device which comprises a spiral expansion device, and a rear base plate of the spiral expansion device is fixed to the rear half section of the maxillary bone through a left anchorage nail and a right anchorage nail. The front base plate and the rear base plate are respectively connected with at least two belt rings through belt ring connecting rods, the left front belt ring and the right front belt ring connected with the front base plate are at least sleeved on the first front molars on the corresponding sides, and the left rear belt ring and the right rear belt ring connected with the rear base plate are sleeved on the first molars and / or the second molars on the corresponding sides; the two front band rings are connected through a labial arch, and a lip baffle is fixed in the middle of the labial arch; a traction hook matched with a front tractor is fixedly connected to the outer ring face of the rear belt ring. According to the utility model, the osteotomy gap between the first premolar and the second premolar can be stably and effectively stretched, so that the aim of correcting skeletal hypoplasia or repairing bone defects is fulfilled.

The invention belongs to the technical field of biology, and particularly relates to a construction method of epigenome edited zebrafish, sgRNA of a targeted zebrafish runx2b gene promoter region and application of the sgRNA. The invention provides a construction method of epigenome edited zebrafish, which comprises the step of carrying out methylation editing by using a CRISPR / dCas9-methyltransferase system targeting runx2b gene promoter region, thereby inhibiting runx2b gene expression and reducing intermuscular bone formation. According to the method, the expression level of the runx2b gene is accurately regulated and controlled through an epigenetic editing technology on the premise that a DNA sequence is not changed, and formation of fish intermuscular bones is effectively reduced. The zebra fish F0 treated by the method represents that the runx2b mRNA expression level is obviously reduced, and the intermuscular bones of the eleventh to sixteenth sarcomedo regions of adult F0 generation fish are obviously shorter than those of a control group, and the shortening range reaches 23.3% to 38.8%. Besides, the method provides theoretical basis and technical support for improving fish economic traits by accurately regulating and controlling the expression mode of the key economic trait gene and simultaneously keeping the integrity of genome DNA (Deoxyribose Nucleic Acid).

This invention discloses a method for in-situ preparation of calcium chelate peptides that promote intestinal calcium absorption and osteoblast development from fish scales using high-pressure homogenization-assisted enzymatic hydrolysis. The method uses fish scales as raw material, which are pulverized and then pretreated with high-pressure homogenization to break down the dense cross-linked structure of the scales. Pepsin is used as the hydrolytic enzyme to achieve efficient enzymatic hydrolysis of collagen and in-situ chelation with natural calcium, resulting in a one-step preparation of collagen calcium chelate peptides. The product has a calcium retention rate of ≥84.16%, is rich in affinity amino acids, and shows a ≥62.97% increase in calcium transport compared to calcium chloride in a small intestinal epithelial cell absorption and transport model, while being safe and non-cytotoxic. This invention is a green and efficient process that eliminates the need for decalcification steps, achieving a collagen calcium chelate peptide yield of ≥83.4%. It realizes the high-value utilization of aquatic by-products and can be directly applied to various calcium supplements such as food and health products that enhance intestinal calcium absorption and promote bone development, solving problems such as low bioavailability of traditional calcium preparations and severe calcium loss in existing fish scale utilization processes.

The invention discloses a special feed for black pigs. The special feed is characterized by comprising the following raw materials: corn, fermented soybean meal, bran, sweet potato vine powder, fish meal, chicken intestine membrane protein powder, composite vitamins, composite minerals, lysine, methionine, table salt and a probiotic preparation. The preparation method of the special feed for the black pigs is characterized by comprising the following steps: S1, pretreating the raw materials; s2, mixing and stirring for the first time; s3, mixing and stirring for the second time; s4, mixing and stirring for the third time; and S5, drying. Aiming at the physiological characteristics of long growth cycle, mild energy and protein requirements and high dietary fiber and mineral substance requirements of black pigs, all the raw material components are accurately proportioned, so that the black pig feed is easier to digest and absorb, reduces the burden of gastrointestinal tracts, promotes intestinal peristalsis, improves the digestive function, meets the requirements of skeletal development and muscle growth, avoids deficiency or excess of micronutrients, and improves the production efficiency. The intestinal flora balance can be adjusted, and the immunity is improved.

This invention relates to a nutritional composition for promoting bone development and its applications. The invention provides applications of the nutritional composition or preparations comprising said nutritional composition, including: (1) preparing food products; (2) preparing health products for promoting bone development, increasing height, and / or improving bone density; (3) preparing drugs or drug compositions for promoting bone development, increasing height, increasing bone density, treating or preventing osteoporosis, and / or treating or preventing skeletal dysplasia; and (4) promoting bone development, increasing height, and / or improving bone density for non-therapeutic purposes; wherein said nutritional composition comprises medium- and long-chain triglycerides (MLCT) and 1,3-diunsaturated fatty acid-2-palmitoyltriglycerides (UPU).

The invention provides mixed structure grease for promoting skeletal development and improving bone mineral density as well as a preparation method and application of the mixed structure grease. The mixed structure grease for promoting skeletal development and improving bone mineral density comprises the following components in percentage by mass: 2-10% of medium-chain fatty acid triglyceride, 10-50% of medium-long-chain fatty acid triglyceride and 40-90% of long-chain fatty acid triglyceride. The traditional Chinese medicine composition can effectively promote skeletal development and improve bone mineral density.

This invention discloses an active peptide from sturgeon cartilage that promotes height growth and improves bone development, along with its preparation method and applications, belonging to the field of active peptide technology. Using sturgeon cartilage as raw material, this invention selects the polypeptide with the highest activity in promoting bone growth and development from different enzymatic hydrolysis combinations through MC3T3-E1 cell experiments, and verifies its positive effect using zebrafish experiments. Subsequently, two potential active peptide sequences from sturgeon cartilage with bone growth and development promotion functions are screened using mass spectrometry to identify their sequences and bioinformatics techniques such as molecular docking. The amino acid sequences of the active peptide segments are shown in SEQ ID NO.2 and SEQ ID NO.5. The sturgeon cartilage peptides prepared by this invention have activity in promoting bone growth and development, which can solve the problem of high-value utilization of sturgeon and can also be used as a functional factor in functional products, showing good application prospects.

The invention relates to the technical field of feed, in particular to application of inulin in improving the laying rate of laying hens and feed efficiency. The laying rate and the feed conversion efficiency are remarkably improved, the laying period is prolonged, meanwhile, the slaughter rate is improved, and the breeding cost is reduced; the eggshell color and structure are adjusted, the eggshell thickness and strength are improved, the egg yolk nutrition index is synchronously improved, and the market competitiveness is enhanced; the serum hormone level is adjusted, the immune response and antioxidant capacity are enhanced, oxidative stress injury is reduced, and the health of chicken flocks is guaranteed; skeletal development and mineral deposition are promoted, serum uric acid and triglyceride levels are adjusted, and metabolic diseases are prevented; the intestinal structure is optimized, the yield of short-chain fatty acid is increased, the content of unsaturated fatty acid in egg yolk is increased, and the flavor and nutritional value of the product are improved; the antibiotic dependence is reduced through a natural substitution mechanism, the trend of green breeding and food safety is met, and the sustainable development of the industry is promoted.

The utility model provides a mandibular push molar distalization device suitable for bony class III malocclusion, which comprises a tail end guide rail, a front end guide rail, a push rod and a sleeve type push spring, the tail end guide rail is fixed on the last tooth needing to be moved, the front end guide rail is fixed on canine teeth or first premolar teeth at the turning position of a dentition dental arch, and the push rod is fixed on the sleeve type push spring. A push rod is arranged between the tail end guide rail and the front end guide rail in a penetrating mode, a traction hook is arranged at the end, penetrating through the front end guide rail, of the push rod, a tail end blocking ball is arranged at the other end, penetrating through the tail end guide rail, of the push rod, a sleeve type push spring is movably connected between the tail end guide rail and the front end guide rail in a sleeved mode, and a free buckle for blocking and limiting the sleeve type push spring is arranged on the push rod. The traction hook is connected with a jaw anchorage component such as an anchorage nail through a rubber band. The mandibular molars can be pushed to the distal direction, the mandibular molars can be pushed to the distal direction, meanwhile, the mandibular molars can assist in promoting the development of the maxilla and inhibiting the development of the mandible for other clinical bony III-type malocclusion orthotic devices, the structure is scientific and reasonable, the mandibular molars are simple and practical, the mechanical analysis is simple and clear, the use comfort of a patient is high, and the orthotic effect is good.

The invention discloses establishment and application of an epinephelus coioides frontal bone tissue osteoblast line, and relates to the technical field of biology. The cell line is an epinephelus coioides frontal bone tissue osteoblast line ECFBOB, the preservation number is CCTCC NO: C2025131, the cell line is derived from the frontal bone tissue of juvenile epinephelus coioides, and the cell line is established after tissue separation, primary culture by a dry pasting method, subculture and cryopreservation resuscitation. The obtained cell line can be used as an in-vitro research model, provides a key technical tool for saddletail grouper improved variety breeding and healthy culture in saddletail grouper skeletal development mechanism analysis, osteogenesis-related gene function verification, craniofacial bone malformation cause research and species traceability verification, fills the blank of saddletail grouper bone tissue cell lines, and has a wide application prospect. The method has important scientific research value and industrial application prospect.

The invention belongs to the technical field of microbial engineering, and discloses a composition for promoting skeletal development and application thereof, and the composition contains bifidobacterium longum subsp. Infantis i18, 2 '-fucosyllactose and lactose-N-neotetraose. All the components in the composition have a synergistic effect, the content of calcium ions in bone cells can be remarkably increased, the bone density is improved, and the purpose of promoting skeletal development is achieved. The preparation method is suitable for preparing formula milk powder capable of promoting skeletal development or health-care food beneficial to improving bone mineral density.

The application provides a casein phosphopeptide with the functions of promoting the absorption of calcium, iron, zinc, manganese and magnesium and improving bone health and a preparation method, and belongs to the technical field of casein phosphopeptide and comprises the following steps: S1, taking casein and adding pepsin for first enzymolysis; S2, taking the first enzymolysis solution, adjusting pH and temperature, and adding a compound enzyme for second enzymolysis; S3, after the second enzymolysis solution is inactivated, the casein phosphopeptide is obtained through treatment. The casein phosphopeptide prepared by the application has the following advantages: 1. can effectively complex mineral elements and reduce ion channel competition inhibition; 2. promotes the absorption of calcium, increases the hardness of the skeleton, and promotes the growth and development of the skeleton; 3. promotes the absorption of magnesium, assists calcium deposition, reduces bone loss, prevents osteoporosis, 3. promotes the absorption of iron, prevents iron deficiency anemia, and improves uncomfortable symptoms such as dizziness and fatigue; 4. promotes the absorption of zinc, enhances the activity of immune cells, improves resistance, and improves appetite. 5. promotes the absorption of manganese, activates the development of the skeleton, accelerates energy metabolism, and has antioxidant effect.

The application provides a child formula milk for promoting bone development and a preparation method thereof, and relates to the technical field of dairy products.The child formula milk for promoting bone development comprises the following raw materials in mass parts: raw cow milk 970-999 parts, a composite vitamin 0.05-1 part, a mineral 0.1-1.5 parts, colostrum basic protein 0.1-1 part and 2'-fucosyllactose 0.1-2 parts; the composite vitamin contains vitamin K, and the mass ratio of 2'-fucosyllactose to the composite vitamin is 0.5:1-20:1; the mass ratio of colostrum basic protein:2'-fucosyllactose: vitamin K: mineral is 1:(1-10):(0.1-0.5):(0.5-10). The child formula milk for promoting bone development can effectively promote bone development and improve product stability through specific content matching of each raw material component.

The present invention provides a combination of vitamin mixtures and synbiotics for use in enhancing bone growth and / or bone strength, for example, in children suffering from and / or developmental delay.

The invention belongs to the technical field of microorganisms and nutriology, and discloses bifidobacterium longum subsp.infantis CICC 6069 for promoting calcium absorption and application of a composition of the bifidobacterium longum subsp.infantis CICC 6069 and vitamin D in improvement of bone health. Cytology experiments and animal models verify that the strain can significantly promote absorption of intestinal epithelial cells to calcium ions and improve the serum calcium level and the calcium apparent absorption rate of calcium-deficient model animals; when the strain is combined with vitamin D, skeletal development (such as increasing bone length and improving bone mineral density) can be further remarkably promoted, and the synergistic effect is remarkably superior to that of single use of the strain. The invention provides an application of bifidobacterium longum infant subCICC 6069 in preparation of related products for promoting calcium absorption, and also provides a composition for promoting calcium absorption and / or improving bone health, and the composition comprises the strain and vitamin D. The invention further provides a preparation method of the bifidobacterium longum infant subCICC 6069 and a preparation method of the bifidobacterium longum infant subCICC 6069. The strain and the composition are suitable for preparing food, health food or medicine for promoting calcium absorption and improving bone health.

The invention provides a teenager orthodontic growth improvement method and system based on bone development prediction, and belongs to the field of image processing.The method comprises the steps that first malformation parameters of mandibular teeth of a patient are obtained according to distribution of pixel points of the lips and the edges of the mandibular teeth of the patient; mapping the mandibular teeth of the patient to the lips to obtain a lip section line of the mandibular teeth of the patient, combining the edge of the mandibular teeth of the patient to obtain an angle malformation parameter of the mandibular teeth of the patient, and combining the position distribution of the mandibular teeth of the patient, the first malformation parameter of the mandibular teeth of the patient, the age of the patient, the highest age of skeletal development and the growth rate constant of the skeletal; and obtaining a predicted value of the comprehensive malformation parameter of the mandibular teeth of the patient at each year old. The objective of the invention is to solve the problems that the subjectivity of the acquired malformation degree of the mandibular teeth of the patient is too strong and the accuracy is too low when the malformation degree of the mandibular teeth of the patient is judged mainly according to experience of a doctor through the image of the mandibular teeth of the patient at present.

The invention belongs to the field of nutriology, and particularly relates to a plant lactobacillus NuPlus-8 capable of synergistically promoting absorption of multiple mineral substances, a product and application. The plant lactobacillus NuPlus-8 disclosed by the invention is derived from healthy breast milk, has good acid-resistant and cholate-resistant characteristics, and can survive and keep activity in related environments of intestinal tracts. The strain has the effect of synergistically promoting absorption of eight nutrient substances including calcium, magnesium, zinc, selenium, iron, phosphorus, vitamin D and protein, and meanwhile promotes skeletal development; phytase can be secreted, phytic acid-mineral compounds can be degraded, combined calcium, magnesium, zinc, selenium, iron and phosphorus can be released, and the solubility and the availability of mineral substances can be improved; and transmembrane transport and absorption of intestinal epithelial cells to various minerals, VD and amino acids are significantly improved. The strain has a unique physiological function of synergistically promoting multi-nutrient absorption, can be used in products for improving nutrient absorption and utilization efficiency, and has remarkable application value and industrial prospect.

The invention discloses an external-use compound formula for assisting skeletal development and cartilage health of teenagers, and belongs to the technical field of external-use health-care preparations. According to the formula, yak bone marrow peptide, glucosamine hydrochloride, chondroitin sulfate and bone collagen peptide serve as core active ingredients, rose hip oil is matched to serve as a transdermal penetration enhancing component, transdermal absorption of the active ingredients is achieved through reasonable matching, osteoblast metabolism of teenagers (6-18 years old) can be promoted in a targeted mode, the bone mineral density can be increased, and the effect of preventing and treating osteoporosis is achieved. Meanwhile, cartilage matrix synthesis is strengthened, cartilage injury is reduced, and the problem that external health care products are deficient in the teenager skeletal cartilage development stage is solved. According to the technical verification of the Zhejiang traditional Chinese medicine university medicine college modern medicine research center, the formula is high in safety and excellent in transdermal efficiency, adapts to teenager skin barrier characteristics, and has remarkable application value in the fields of teenager skeletal development and cartilage health maintenance.

This invention discloses a method for preparing calcium chelating peptides that promote intestinal calcium absorption and their application in promoting bone development and preventing osteoporosis, belonging to the field of food biotechnology. Using fish scales, a byproduct of aquatic product processing, as raw material, this invention prepares collagen calcium peptide hydrolysates through enzymatic hydrolysis, and further chelates and enriches them to prepare collagen calcium peptide chelates. Highly active calcium chelating peptides that promote intestinal calcium absorption are identified by HPLC-MS / MS technology. Experiments show that the peptides are safe and non-toxic, and in a Caco-2 small intestinal epithelial cell model, they can promote intestinal calcium transport and absorption, significantly increasing the amount compared to the calcium chloride control group. Molecular docking confirms that the peptides can stably bind to the EGFR active pocket, mediating osteogenic activity through hydrogen bonds, hydrophobic interactions, and electrostatic interactions. Within a concentration range of 1-100 μg / mL, they can significantly promote osteoblast proliferation and differentiation activity and enhance the formation of osteogenic mineralized nodules, exhibiting significant intestinal calcium absorption and osteogenic activity.

The invention discloses nutritional composite powder for promoting growth and bone age balance. The milk powder is prepared from the following raw materials in parts by weight: 30-50 parts of modified milk powder, 15-25 parts of whey protein concentrate, 5-10 parts of compound minerals, 0.3-0.7 part of gamma-aminobutyric acid, 0.1-0.3 part of L-lysine, 0.4-0.6 part of bone collagen peptide, 2-5 parts of hydrolyzed yolk powder, 1-3 parts of yolk globulin, 3-6 parts of milk minerals, 2-4 parts of yolk phospholipoprotein, 1-3 parts of compound vitamins and 1-2 parts of citrus fibers. The health food is prepared from 1-2 parts of poria cocos powder, 1-2 parts of Chinese yam powder, 0.5-1 part of endothelium corneum gigeriae galli powder, 0.3-0.5 part of taurine, 1-3 parts of lactic acid bacteria compound powder, 1-2 parts of inulin and 0.1-0.3 part of fructus momordicae powder. The invention belongs to the technical field of nutritional food, and particularly provides nutritional composite powder capable of promoting growth and bone age balance, which is comprehensive in nutritional ingredients, scientific in proportion, capable of effectively supplementing various nutrients required by growth and development of teenagers, capable of remarkably promoting skeletal development, capable of improving body immunity and capable of providing comprehensive nutritional support for healthy growth of the teenagers.

The invention discloses a feeder cattle fattening feed and a preparation method thereof, and the feeder cattle fattening feed comprises the following components in parts by weight: corn straw, sassafras leaves, medicago sativa, myriophyllum spicatum, myotonin, feather meal, fishbone dust, calcium hydrogen phosphate, carrots, salt, soybean oil, a traditional Chinese medicine additive, betaine and cane sugar. The corn straw and the sassafras leaves provide crude fibers to promote rumen fermentation, the feather meal and the fish bone meal supplement high-quality protein, and the palatability is improved through a puffing process. The traditional Chinese medicine additive can significantly improve the serum immune globulin level and reduce common diseases such as cold and diarrhea. Calcium hydrogen phosphate promotes calcium and phosphorus absorption and improves skeletal development; the probiotics and the dietary fibers cooperate to regulate the intestinal microecology. The double-shaft extrusion puffing process shortens a raw material processing chain and reduces energy consumption, puffed particles are long in storage time, process data are recorded to a block chain to facilitate data tracking, and the method is suitable for being used in large-scale farms.

The application provides a preparation method of yak bone collagen peptide, a composition for promoting bone development and application thereof, and relates to the technical field of health foods.The preparation method comprises the following steps: after ultrasonic pretreatment of yak bone, supercritical CO2 is used for defatting to obtain a defatted product; the defatted product is mixed with a deodorizing agent to obtain a deodorized product; the deodorizing agent is an aqueous solution of a plant extract; the plant extract is at least one selected from the group consisting of Amomum tsao-ko extract, turmeric extract, green tea extract and momordica grosvenori extract; the deodorized product is subjected to enzymolysis reaction through a fixed immobilized enzyme reactor, the complex enzyme is prolyl endopeptidase, papain and ficin; a crude product is obtained; the crude product is subjected to ultrafiltration through a filter membrane with a molecular weight cut-off of 1kDa and is subjected to macroporous resin adsorption.The yak bone collagen peptide and the composition prepared by the method can significantly improve body length, promote bone development and promote the secretion of growth hormone, and meet the growth needs of children.

The invention belongs to the technical field of microorganisms, and particularly relates to application of bifidobacterium longum B188 in products for promoting calcium absorption and skeletal development. The preservation number of the bifidobacterium longum B188 is GDMCC No: 67123, and the bifidobacterium longum B188 can play roles through multiple mechanisms: the intestinal calcium absorption efficiency is improved so as to repair the calcium metabolism steady state and regulate serum related indexes; bone formation is promoted, bone resorption is inhibited, and bone health related markers are regulated and controlled; growth and development disorders caused by low-calcium diet are improved, organ indexes are adjusted, bone trabecula structures are repaired, bone mineral density is improved, and cortical bone thickness is increased. The strain can be used for preparing functional foods, health foods or dietary supplements for promoting calcium absorption and improving skeletal development, and a new scheme is provided for intervention of related problems of calcium metabolism.

The invention relates to a calcium-containing food supplement that differs from its counterparts in that it contains Lysine amino acid, which contributes to the absorption of calcium, and Arginine amino acids, which enable the utilisation of calcium in the metabolic process, which is generally developed for use in supporting bone and bone development metabolism, in order to support the prevention of Osteoporosis, Maleostasis, seen in women after menopause; in adult men, to contribute positively to the solution of problems in the absorption and utilisation of calcium that occur in bone metabolism with aging; To protect dental health and in dental implant treatment, to ensure the stability of the implant by surrounding the implant surface of the bone tissue; to ensure that children have stronger bones and, to the extent permitted by genetic factors, longer bones and therefore taller stature at the developmental age; Depending on various factors, to support the absorption and transport of calcium in skeletal problems, to support faster and better union of bone fractures.

This invention relates to a polypeptide derived from lactoferrin and its uses. The amino acid sequence of the polypeptide is shown in any one of SEQ ID NO:1 to SEQ ID NO:3. The polypeptide of this invention is not only non-toxic and highly safe, but also exhibits good osteogenic activity, specifically promoting osteoblast proliferation, differentiation, and mineralization, and increasing the calcium ion content within osteoblasts. Therefore, the polypeptide of this invention has a positive effect on bone development due to its good osteogenic activity and can be used in the preparation of food (e.g., infant formula).

This invention, entitled "Application of Bifidobacterium animalis subsp. lactis and its post-biotic in bone development," belongs to the field of microbial technology. The technical problem to be solved is to provide a Bifidobacterium animalis subsp. lactis and its post-biotic that promotes bone development. The key technical solution is a Bifidobacterium animalis subsp. lactis BL-16, with accession number CGMCC No. 32050. Bifidobacterium animalis subsp. lactis BL-16 possesses excellent acid and bile salt tolerance, intestinal epithelial cell adhesion ability, and high-efficiency fermentation performance. Its post-biotic (WISYNBIO-16, abbreviated as W16) can regulate the expression of bone metabolism-related genes, significantly promote bone growth and individual development, and has no side effects such as insulin resistance. It can also regulate the expression of key neurotransmitters and regulate the intestinal flora, showing broad application prospects in the preparation of products for bone development.

The invention relates to goat milk powder for promoting skeletal development and a preparation method thereof. According to the technical scheme, each ton of finished product powder comprises the following components in percentage by mass: 760 kg of raw goat milk, 75 kg of isomaltooligosacharide, 50 kg of demineralized whey powder, 75 kg of whey protein powder, 30 kg of inulin, 2 kg of compound vitamins, 1.5 kg of compound minerals, 1.1 kg of compound choline chloride, 0.8 kg of selenium-enriched yeast, 2 kg of DHA, 0.5 kg of hydrolyzed yolk powder, 0.2 kg of N-acetylneuraminic acid, 0.1 kg of lutein ester, 0.2 kg of colostrum basic protein and 0.5 kg of triple compound probiotic powder. The goat milk powder is prepared through the steps of raw material pretreatment, mixing and homogenizing, nutrient enrichment, probiotic addition, concentration, spray drying, packaging and inspection. The invention has the following beneficial effects: various components for promoting skeletal development effectively promote healthy development of bones, promote nutrient absorption and improve immunity.

The invention belongs to the technical field of medical image processing and computer-aided diagnosis, and provides a child humerus supracondylar fracture typing auxiliary method based on a visual large model, which comprises the following steps: acquiring positive and lateral X-ray digital images of a child elbow joint; dimension standardization, lightweight non-local mean denoising, contrast limited adaptive histogram equalization, and Z-score gray normalization preprocessing are carried out; coarsely positioning the distal humerus through Yov8n, determining a bone main direction axis in combination with Canny edge detection and probabilistic Hough transform, and rotating and aligning to obtain a standardized ROI (Region of Interest); key point detection calculates geometric feature vectors such as a Baumann angle, a visual large model extracts a depth image feature vector, and an attention mechanism fuses the two; and the inference model obtains a preliminary Gartland typing probability according to the fused features, introduces child humerus development knowledge graph constraints, and finally outputs a typing probability. The child humerus supracondylar fracture Gardland typing auxiliary diagnosis method not only adapts to child skeletal development characteristics, but also improves the decision credibility through interpretable output, and achieves accurate and efficient auxiliary diagnosis of child humerus supracondylar fracture Gardland typing.

The application relates to the technical field of active peptides, and discloses an egg yolk-derived active peptide for promoting bone growth and a preparation method. The preparation method is as follows: the poultry eggs are cleaned, selected, sterilized and dried to obtain sterile poultry eggs; the egg yolk is subjected to spray drying to obtain egg yolk powder, and the egg yolk powder is subjected to defatting treatment to obtain defatted egg yolk powder; the defatted egg yolk powder is sieved, and deionized water is added to obtain a defatted egg yolk powder suspension; the pH and temperature of the defatted egg yolk powder suspension are adjusted, and enzyme hydrolysis is carried out to obtain an enzyme hydrolysate; the enzyme hydrolysate is inactivated and stored; the enzyme hydrolysate is added with calcium lactate and zinc lactate, and thermophilic fat Bacillus stearothermophilus is added, and fermentation is carried out to obtain a fermentation liquor; and an active peptide solution is separated. The application adopts the above egg yolk-derived active peptide for promoting bone growth and the preparation method, small-molecular-weight active peptides are obtained through step-by-step enzyme hydrolysis and fermentation, the active peptides are easy to absorb, and calcium ions and zinc ions are added during the fermentation, so that the active peptides are chelated with metal ions, growth and bone development are promoted.