148 results about "Bone development" patented technology

Molecules comprising the antigen-binding portion of antibodies that block constitutive and / or ligand-dependent activation of a receptor protein tyrosine kinase, such as fibroblast growth factor receptor 3 (FGFR3), are found through screening methods, where a soluble dimeric form of a receptor protein tyrosine kinase is used as target for screening a library of antibody fragments displayed on the surface of bacteriophage. The molecules of the present invention which block constitutive activation can be administered to treat or inhibit skeletal dysplasia, craniosynostosis disorders, cell proliferative diseases or disorders, or tumor progression associated with the constitutive activation of a receptor protein tyrosine kinase.

The present invention relates to a heparin-derivatized collagen matrix comprising a fragment of heparin covalently linked to a collagen scaffold, wherein the fragment of heparin has molecular weight of less than about 15 kDa, and at least one heparin-binding growth factor (HBGF) or heparin-binding adeno-associated virus (HB-AAV) or a combination thereof and methods for promoting bone growth, bone repair, cartilage repair, bone development, neo-angiogensis, wound healing, tissue engraftment and muscle tissue regeneration and / or tissue augmentation comprising administering a heparin-derivatized collagen matrix that includes at least one heparin-binding growth factor or heparin-binding adeno-associated virus or a combination thereof.

The invention discloses a web database based online bone age calculating and height predicating method. The method comprises the following steps: dividing hand wrist and bone age level; recording thebase information of testing people; inputting shot hand and wrist X ray images; decoding bone data; calculating the bone age; and calculating the predicated height. The method is applicable to professors with evaluation experience; the works such as general sheet checking, recording and summing can be saved; a computer supports. Therefore, the repeating workload can be greatly decreased; the calculation accuracy is improved; various hand wrist bone development standard data can be stored on the basis of the web database, so that the completeness, the safety and the handleability of the data can be ensured; in addition, different predication results can be examined and compared based on different bone age evaluation standards during use; the web database is adopted, so that the characteristics of high efficiency and expandability are met while a new bone age evaluation standard is added; and the method is high in application and popularization value and economic benefit.

The invention discloses a bone age prediction method based on deep learning. The bone age prediction method comprises the following steps: step 1, obtaining the size of a target bone self-adaptive shear frame according to the age, gender and present height; step 2, performing automatic shearing according to the size of the shear frame and the coordinates of the target bone center point to obtain atarget bone picture; step 3, inputting the picture obtained in the step 2 into a bone development grade classification model for recognition to obtain a predicted development grade of each bone; andstep 4, referring to the score table of each bone development stage of a CHN method and a CHN method bone development maturity score and bone age comparison table to obtain a final bone age predictionresult. The invention also provides a bone age prediction system based on deep learning. The method has better stability and accuracy.

A combination dental implant / prosthetic support and distractor for facilitating distraction osteogenesis comprises a basically cylindrical shaft having a set of threads on the outside surface and a smooth, distal tip which bears against the bone of the jaw of the patient. Rotation of the device in the mouth of the patient, after a suitable surgical cut is made, causes the adjacent tissue to move or ride up the screw threads to create space between the cut jaw segment and the balance of the jaw tissue. This space is then filled in by distraction osteogenesis. The implant / distractor is left in-situ, after the distraction is finished, for securement thereto of a dental prosthetic, either a bridge or crown. In an embodiment of the invention, a flat disc is placed in the blind bore drilled into the jaw such that the distal tip of the shaft of the combined implant / distractor, will bear against it. A protective cap and / or collar can be provided, suitable shaped, to protect the shaft / gum line from bacterial attack. Also, the shaft may be provided with an internal passageway and one or more radially extending branches. Growth-enhancing material can be passed through the passageway and branches to promote bone development and recovery. In another embodiment, a coronal member is provided, extra-osseously, to facilitate the distraction osteogenesis process. In one version of the device, fluting is provided to the exterior surface of the shaft so that bone growth is enhanced at that intersection. Also, the shaft can be provided with a flat disc at its head to reduce rocking of the device in the mouth.

The invention provides methods and compositions for differentiating stromal cells from adipose tissue into cells having osteoblastic properties, and methods for improving a subject's bone structure. The methods comprise culturing stromal cells from adipose tissue in β-glycerophosphate and ascorbic acid and / or ascorbate-2-phosphate for a time sufficient to allow differentiation of said cells into osteoblasts. Such methods and compositions are useful in the production of osteoblasts for autologous transplantation into bone at a surgical site or injury. The compositions comprise adipose stromal cells, a medium capable of supporting the growth of fibroblasts and amounts of β-glycerophosphate and ascorbic acid and / or ascorbic-2 phosphate sufficient to induce the differentiation of said stromal cells into osteoblasts. The invention further provides methods of identifying compounds that affect osteoblast differentiation. Such compounds are useful in the study of bone development and in the treatment of bone disorders, including bone fractures and osteoporosis.

The invention discloses a high-fecundity meat-type Anhui white goat lamb breeding technology. A complete feeding management system is made according to specific physiology and growth characteristics of Anhui white goats and includes sterilization, heat insulation, milk drinking, feed supplementing, weaning, sanitation, epidemic prevention and the like of newly born lambs. The breeding technology is scientific in feeding method and appropriate in management and can guide farmers to scientifically feed the goats, and breeding benefits of the goats are improved. According to the breeding technology, by a scientific and effective management mode, the survival rate of the lambs is increased, bone development is facilitated, and subsequent growth and development of the lambs are greatly facilitated.

The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

The invention relates to the technical field of poultry cultivation, in particular to a breeding method for increasing the survival rate of forcibly-weaned lambs. The breeding method comprises the following steps: forcibly weaning the lambs aged 10 days; after weaning, performing adaptation period management, internal organ development promoting management and bone development promoting management and respectively feeding different diets during management. According to the breeding method for increasing the survival rate of the forcibly-weaned lambs, provided by the invention, the lambs aged 10 days can be quickly weaned, and after weaning, the good development of various signs of the lambs can be ensured. When the breeding method provided by the invention is adopted for performing weaning management on the lambs aged 10 days, the overall incidence of various diseases during management is lower than 0.03 percent, the development indexes of internal organs are higher, the bone development is faster, and the weight increasing speed is high.

The present invention relates to methods and materials used to express the HBM protein in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

The invention discloses a food for promoting growth of children and a preparation method of the food and belongs to the field of foods. The food for promoting growth of the children is prepared from the following raw materials in parts by weight: 5-20 parts of purple yam rhizome, 2-10 parts of poria cocos and 1-10 parts of gorgon fruit. The food is complete in nutrition and is beneficial to coordinating intestines and stomach of the children, protecting eyesight, promoting absorption of nutrition and calcium, enhancing children immunity, promoting bone development and thus promoting healthy growth of the children. The preparation method mixes the raw materials of the food for promoting growth of the children according to a ratio, is simple in formula, convenient to operate and low in costand is suitable for scale production.

The present invention relates to the use of SHIP1 inhibitors and pan-SHIP1 / 2 inhibitors in various methods, including, without limitation: (i) a method to treat obesity or reduce body fat of an obese subject; (ii) a method to limit bone development in a subject suffering from an osteopetrotic or sclerotic disease; (iii) a method to treat or prevent diabetes; (iv) a method to reduce glucose intolerance or insulin resistance; and (v) a method to lower cholesterol.

The invention discloses a compound premix additive for improving bone development of replacement gilts. The compound premix additive is prepared from, by weight, 30-40 parts of vitamin complex, 40-60 parts of trace element composite, 30-40 parts of choline chloride, 40-60 parts of L-lysine hydrochloride, 10-15 parts of DL-methionine, 5-10 parts of L-threonine, 120-150 parts of calcium hydrophosphate, 120-150 parts of monocalcium phosphate, 250-280 parts of limestone powder, 90-110 parts of salt and 85-265 parts of bran. By adoption of the compound premix additive, bone toughness and strength of the replacement gilts can be improved, reserve quantity of nutrients such as vitamins, trace elements and the like in the replacement gilts is increased, and accordingly occurrence rate of the foot-and-leg disease of the gilts is decreased, health of feet and legs of the gilts is protected, and lives of the gilts are prolonged.