80 results about "Bone development" patented technology

The invention provides a method for constructing a skeleton prediction model based on an ROI-HU database and application, image segmentation is performed based on skeleton CT image data of different age groups, and a corresponding ROI-HU database is constructed based on pixel data of a constructed ROI region and an extracted Hu value. Regression training is carried out based on data features in a database, and a skeleton prediction model is constructed and can be used for predicting skeleton attributes of skeletons of patients at different age groups. According to the method, the patient can know the bone mineral density value of the corresponding age group, and can predict the bone attribute of the next stage, so that the patient can conveniently track and know the own bone development state in time. The bone attribute prediction is carried out based on the two indexes, meanwhile, the patient can know whether the bone of the patient has lesions or not, treatment can be carried out in time, and the prediction accuracy is improved.

The invention provides a milk powder composition containing breast milk oligosaccharide and easy to digest and absorb. The milk powder composition comprises the breast milk oligosaccharide, OPN, galactooligosaccharide, lactoferrin, alpha-whey protein, multivitamins, lactose, vegetable oil and compound minerals, wherein the weight ratio of the lactoferrin to the OPN to the breast milk oligosaccharide to the galactooligosaccharide is 1: (2-4): (2-50): (4-100). The composition can effectively recover and improve the intestinal barrier function caused by inflammatory factors, can be well absorbed by infants with poor digestion and absorption functions, reduces diarrhea and promotes skeletal development.

The invention relates to the technical field of microorganisms, and particularly discloses bifidobacterium adolescentis AGE17 capable of promoting growth and development of muscles and bones and application of the bifidobacterium adolescentis AGE17. The bifidobacterium adolescentis AGE17 is separated from excrement of healthy children and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.33452, and the preservation date is January 17, 2025. The bifidobacterium adolescentis AGE17 has the advantages that the bifidobacterium adolescentis AGE17 can be used for preparing the biological organic fertilizer; animal experiments prove that the bifidobacterium adolescentis strain AGE17 provided by the invention has the function of promoting muscle and skeletal development, has more obvious and prominent effects compared with a model strain bifidobacterium adolescentis ATCC15703, and has important application value in increasing the muscle strength and height of children and adolescents.

The invention provides a preparation method of yak bone collagen peptide, a composition for promoting skeletal development and application of the composition, and relates to the technical field of health food. The preparation method comprises the following steps: carrying out ultrasonic pretreatment on yak bones, and degreasing through supercritical CO2 to obtain a degreased product; mixing the degreased product with a fishy smell removing agent to obtain a fishy smell removing product; the fishy smell removing agent is an aqueous solution of a plant extract; the plant extract is selected from at least one of amomum tsao-ko extract, turmeric extract, green tea extract or momordica grosvenori extract; the fishy smell removal product is subjected to an enzymatic hydrolysis reaction through an immobilized compound enzyme reactor, wherein the compound enzyme is prolyl endopeptidase, papain and ficin; obtaining a crude product; carrying out ultrafiltration by adopting a filter membrane with the molecular weight cut-off of 1kDa, and adsorbing through macroporous resin. The yak bone collagen peptide and the composition prepared by the invention can obviously improve the body length, promote the skeletal development and promote the secretion of growth hormone, and meet the growth requirements of children.

The application discloses a flavonoid compound in eaglewood as well as a preparation method and application of the flavonoid compound, and relates to the technical field of medicines. The application extracts and separates a new compound from natural eaglewood, and the new compound is used in the preparation of anti-osteoporosis drugs. The compound is detected in vitro to obtain an induction effect of the compound on the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts, so as to affect the formation of osteoclasts. Meanwhile, the compound can promote the bone development of zebra fish through RT-qPCR detection, which indicates that the compound has anti-osteoporosis activity. The separation method of the compound is simple and easy to operate.

The invention discloses sturgeon cartilage active peptide capable of promoting growth and improving bone development as well as a preparation method and application of the sturgeon cartilage active peptide, and belongs to the technical field of active peptide. According to the invention, sturgeon cartilage is taken as a raw material, polypeptide with the highest activity of promoting bone growth and development is selected from different enzymolysis combinations through MC3T3-E1 cell tests, and the positive effect of the polypeptide is verified through zebra fish tests; then, two potential sturgeon cartilage active peptide sequences with the function of promoting bone growth and development are screened out through bioinformatics technologies such as mass spectrum identification, molecular docking and the like, and the amino acid sequences of the sturgeon cartilage active peptide fragments are shown as SEQ ID NO.2 and SEQ ID NO.5. The sturgeon cartilage peptide prepared by the method disclosed by the invention has the activity of promoting bone growth and development, can solve the problem of high-value utilization of sturgeons, can also be applied to functional products as a functional factor, and has a good application prospect.

The invention relates to an application of plant lactobacillus Hi188 in promotion of bone health. The invention provides the application of the plant lactobacillus Hi188 or the afterbiogen thereof or the composition thereof in increasing the bone mineral density, increasing the bone mineral density, promoting the skeletal development, increasing the bone mineral content and / or promoting the tibia growth. Or preparing food for increasing bone mineral density, increasing bone mineral density, promoting skeletal development, increasing bone mineral content and / or promoting tibia growth; wherein the composition comprises: (A) Phytobacterium plantarum Hi188 or a postbiotic thereof, and (B) Bifidobacterium lactis Ca360 or a postbiotic thereof.

The utility model provides a bone anchorage type maxillary distraction osteogenesis device which comprises a spiral expansion device, and a rear base plate of the spiral expansion device is fixed to the rear half section of the maxillary bone through a left anchorage nail and a right anchorage nail. The front base plate and the rear base plate are respectively connected with at least two belt rings through belt ring connecting rods, the left front belt ring and the right front belt ring connected with the front base plate are at least sleeved on the first front molars on the corresponding sides, and the left rear belt ring and the right rear belt ring connected with the rear base plate are sleeved on the first molars and / or the second molars on the corresponding sides; the two front band rings are connected through a labial arch, and a lip baffle is fixed in the middle of the labial arch; a traction hook matched with a front tractor is fixedly connected to the outer ring face of the rear belt ring. According to the utility model, the osteotomy gap between the first premolar and the second premolar can be stably and effectively stretched, so that the aim of correcting skeletal hypoplasia or repairing bone defects is fulfilled.

The invention relates to the technical field of active peptides, and discloses a yolk-derived active peptide for promoting bone growth and a preparation method thereof. The preparation method comprises the following steps: cleaning, selecting, sterilizing and drying poultry eggs to obtain sterile poultry eggs; performing spray drying on yolk to obtain yolk powder, and performing degreasing treatment to obtain degreased yolk powder; sieving the degreased egg yolk powder, and adding deionized water to obtain a degreased egg yolk powder suspension; adjusting the pH and temperature of the degreased yolk powder suspension, and performing enzymolysis to obtain enzymatic hydrolysate; inactivating the enzymatic hydrolysate for later use; adding calcium lactate and zinc lactate into the enzymatic hydrolysate, adding geobacillus stearothermophilus, and fermenting to obtain fermentation liquor; separating to obtain an active peptide solution. According to the yolk-sourced active peptide for promoting bone growth and the preparation method, the active peptide with small molecular weight is obtained through distributed enzymolysis and fermentation and is easy to absorb, and calcium ions and zinc ions are added during fermentation, so that the active peptide is chelated with metal ions, and growth and bone development are promoted.

The invention belongs to the technical field of biology, and particularly relates to a construction method of epigenome edited zebrafish, sgRNA of a targeted zebrafish runx2b gene promoter region and application of the sgRNA. The invention provides a construction method of epigenome edited zebrafish, which comprises the step of carrying out methylation editing by using a CRISPR / dCas9-methyltransferase system targeting runx2b gene promoter region, thereby inhibiting runx2b gene expression and reducing intermuscular bone formation. According to the method, the expression level of the runx2b gene is accurately regulated and controlled through an epigenetic editing technology on the premise that a DNA sequence is not changed, and formation of fish intermuscular bones is effectively reduced. The zebra fish F0 treated by the method represents that the runx2b mRNA expression level is obviously reduced, and the intermuscular bones of the eleventh to sixteenth sarcomedo regions of adult F0 generation fish are obviously shorter than those of a control group, and the shortening range reaches 23.3% to 38.8%. Besides, the method provides theoretical basis and technical support for improving fish economic traits by accurately regulating and controlling the expression mode of the key economic trait gene and simultaneously keeping the integrity of genome DNA (Deoxyribose Nucleic Acid).

This invention discloses a method for in-situ preparation of calcium chelate peptides that promote intestinal calcium absorption and osteoblast development from fish scales using high-pressure homogenization-assisted enzymatic hydrolysis. The method uses fish scales as raw material, which are pulverized and then pretreated with high-pressure homogenization to break down the dense cross-linked structure of the scales. Pepsin is used as the hydrolytic enzyme to achieve efficient enzymatic hydrolysis of collagen and in-situ chelation with natural calcium, resulting in a one-step preparation of collagen calcium chelate peptides. The product has a calcium retention rate of ≥84.16%, is rich in affinity amino acids, and shows a ≥62.97% increase in calcium transport compared to calcium chloride in a small intestinal epithelial cell absorption and transport model, while being safe and non-cytotoxic. This invention is a green and efficient process that eliminates the need for decalcification steps, achieving a collagen calcium chelate peptide yield of ≥83.4%. It realizes the high-value utilization of aquatic by-products and can be directly applied to various calcium supplements such as food and health products that enhance intestinal calcium absorption and promote bone development, solving problems such as low bioavailability of traditional calcium preparations and severe calcium loss in existing fish scale utilization processes.

The application relates to the field of microbial technology, and particularly discloses a Bifidobacterium adolescentis AGE17 for promoting muscle and bone growth and development and an application thereof. Bifidobacterium adolescentis The Bifidobacterium adolescentis AGE17 is isolated from the feces of healthy children, is preserved in the China General Microbiological Culture Collection Center, and has a preservation number of CGMCC No. 33452 and a preservation date of January 17, 2025. Animal experiments prove that the Bifidobacterium adolescentis strain AGE17 provided by the application has the function of promoting muscle and bone development, has more obvious and prominent effects compared with a model strain Bifidobacterium adolescentis ATCC15703, and has important application values in increasing the muscle strength and height of children and teenagers.

The invention discloses a special feed for black pigs. The special feed is characterized by comprising the following raw materials: corn, fermented soybean meal, bran, sweet potato vine powder, fish meal, chicken intestine membrane protein powder, composite vitamins, composite minerals, lysine, methionine, table salt and a probiotic preparation. The preparation method of the special feed for the black pigs is characterized by comprising the following steps: S1, pretreating the raw materials; s2, mixing and stirring for the first time; s3, mixing and stirring for the second time; s4, mixing and stirring for the third time; and S5, drying. Aiming at the physiological characteristics of long growth cycle, mild energy and protein requirements and high dietary fiber and mineral substance requirements of black pigs, all the raw material components are accurately proportioned, so that the black pig feed is easier to digest and absorb, reduces the burden of gastrointestinal tracts, promotes intestinal peristalsis, improves the digestive function, meets the requirements of skeletal development and muscle growth, avoids deficiency or excess of micronutrients, and improves the production efficiency. The intestinal flora balance can be adjusted, and the immunity is improved.

The invention discloses a bone development capability evaluation method and device, and relates to the technical field of image processing, and the method comprises the steps: receiving a preset bone X-ray image of a target user, and extracting key features of bone growth; calling a pre-trained bone development capability evaluation model to analyze the bone growth key features, and generating an initial bone development evaluation result; and acquiring preset bone use information of the target user, comparing the preset bone use information with the model sample parameters, correcting an evaluation result by configuring a feedback coefficient, and generating a personalized target bone development evaluation report. The technical problems that an existing bone development assessment method is high in subjectivity, insufficient in individual difference consideration and lack of a dynamic correction mechanism, and consequently the assessment accuracy and the individuation degree are low are solved, and the purpose that the assessment accuracy and the individuation degree are improved by combining automatic image analysis, individualized bone use information and the correction mechanism is achieved. And the accuracy, individuation and reliability of bone development evaluation are improved.

This invention relates to a nutritional composition for promoting bone development and its applications. The invention provides applications of the nutritional composition or preparations comprising said nutritional composition, including: (1) preparing food products; (2) preparing health products for promoting bone development, increasing height, and / or improving bone density; (3) preparing drugs or drug compositions for promoting bone development, increasing height, increasing bone density, treating or preventing osteoporosis, and / or treating or preventing skeletal dysplasia; and (4) promoting bone development, increasing height, and / or improving bone density for non-therapeutic purposes; wherein said nutritional composition comprises medium- and long-chain triglycerides (MLCT) and 1,3-diunsaturated fatty acid-2-palmitoyltriglycerides (UPU).

The invention provides mixed structure grease for promoting skeletal development and improving bone mineral density as well as a preparation method and application of the mixed structure grease. The mixed structure grease for promoting skeletal development and improving bone mineral density comprises the following components in percentage by mass: 2-10% of medium-chain fatty acid triglyceride, 10-50% of medium-long-chain fatty acid triglyceride and 40-90% of long-chain fatty acid triglyceride. The traditional Chinese medicine composition can effectively promote skeletal development and improve bone mineral density.

An orthopedic system and method for treating a femoral fracture in, for example, a skeletally immature patient. The system and method including an intramedullary nail arranged and configured to be implanted within, for example, a femur of a skeletally immature patient. The system and method further including a bone screw (100) including a distal region (110) and a proximal region (130), wherein the distal region (110) is devoid of any threads so that the patient's bone is free to grow overtime.

The invention discloses a construction method and application of an adriamycin-induced zebrafish osteoporosis-like model, and the construction method comprises the following steps: by utilizing the characteristics of transparency and rapid bone development of zebrafish embryos and juvenile fishes, selecting the zebrafish embryos of 2dpf, and culturing the zebrafish embryos to 6dpf in an adriamycin aqueous solution of 20 mu m, so as to obtain the adriamycin-induced zebrafish osteoporosis-like model. Therefore, the visual zebrafish osteoporosis-like model is efficiently constructed, juvenile fish bodies are transparent, imaging is visual, bone development changes can be observed in vivo in real time, and visual evaluation of bone development injuries is achieved. The built zebrafish osteoporosis-like model clearly shows the systematic inhibition effect of chemotherapy drugs on bone formation and mineralization, has the advantages of being short in building period, easy and convenient to operate, high in repeatability and sensitive to drug reaction, can be used for rapid dose screening and intervention experiments, and has good application prospects. The method has great application potential in research of pathogenesis of CIOP, screening of anti-osteoporosis drugs and evaluation of curative effect of the anti-osteoporosis drugs.

This invention discloses an active peptide from sturgeon cartilage that promotes height growth and improves bone development, along with its preparation method and applications, belonging to the field of active peptide technology. Using sturgeon cartilage as raw material, this invention selects the polypeptide with the highest activity in promoting bone growth and development from different enzymatic hydrolysis combinations through MC3T3-E1 cell experiments, and verifies its positive effect using zebrafish experiments. Subsequently, two potential active peptide sequences from sturgeon cartilage with bone growth and development promotion functions are screened using mass spectrometry to identify their sequences and bioinformatics techniques such as molecular docking. The amino acid sequences of the active peptide segments are shown in SEQ ID NO.2 and SEQ ID NO.5. The sturgeon cartilage peptides prepared by this invention have activity in promoting bone growth and development, which can solve the problem of high-value utilization of sturgeon and can also be used as a functional factor in functional products, showing good application prospects.

The present invention belongs to the field of microbial technology, and specifically relates to a Lactobacillus reuteri that can promote mineral absorption and improve bone metabolism, and its products and applications. Lactobacillus reuteri LR-01, deposited with the General Microbiology Center of the China National Committee for the Administration of Microbiological Culture Collection, under the accession number CGMCC No. 17754, was deposited on May 10, 2019. The Lactobacillus reuteri LR-01 provided by the present invention can balance height and weight, promote physical development in children, enhance mineral absorption, increase mineral bioavailability, improve bone metabolism, and promote healthy bone development. It has broad application prospects in the preparation of products that promote growth and development and nutrient absorption.

The present invention provides a method and application for constructing a bone prediction model based on a ROI-HU database, performing image segmentation based on bone CT image data of different age groups, and constructing a corresponding ROI-HU database based on the pixel data of the constructed ROI area and the extracted Hu value. Regression training is performed based on the data features in the database to construct a bone prediction model, which can be used to predict the bone properties of patients' bones in different age groups. Patients can understand the bone density value they should have in the corresponding age group, and can predict the bone properties they should have in the next stage, so that patients can track and understand their own bone development status in a timely manner. The prediction of bone properties is based on two indicators, and patients can also be informed of factors such as whether their bones have lesions, so that they can start treatment in time and improve the accuracy of prediction.

The present invention relates to a nutritional composition, a food and a medicine comprising the nutritional composition, and their uses. The nutritional composition comprises medium and long chain fatty acid triglycerides and human milk oligosaccharides, and the weight ratio of the medium and long chain fatty acid triglycerides to the human milk oligosaccharides is 1:1 to 9:1. The nutritional composition of the present invention can synergistically promote bone development, particularly improve bone density.

The invention relates to the use of a microbiota-modulating agent for enhancing bone development and / or bone strength. wherein the microbiota-modulating agent modulates the abundance of one or more bacterial taxa selected from Intestinimonas butyriciproducens, Turicibacter sanguinis, Paraprevotella clara, and Acidaminococcaceae in the gut of the subject.

The invention relates to the technical field of feeds, and discloses a mystus guttatus feed and a preparation method thereof, the mystus guttatus feed comprises the following raw materials by mass: 25-32 parts of fish meal, 20-25 parts of soybean meal, 30-35 parts of corn flour, 5-8 parts of fish oil, 1-2 parts of spirulina powder, 0.5-1.5 parts of a vitamin additive, 1-3 parts of a mineral additive, and 0.3-2 parts of a Chinese herbal medicine additive; the Chinese herbal medicine additive comprises the following components in parts by mass: 10-20 parts of boxthorn leaves, 5-10 parts of astragalus stems and leaves, 9-11 parts of pericarpium citri reticulatae, 8-15 parts of angelica sinensis, 3-5 parts of longan aril and 1-2 parts of fructus aurantii. According to the scheme, Chinese herbal medicine components such as boxthorn leaves, astragalus membranaceus, pericarpium citri reticulatae, angelica sinensis, fructus aurantii and longan aril are added into the feed, so that the immunity of mystus guttatus can be remarkably improved, diseases are reduced, meanwhile, the physiological function of mystus guttatus can be adjusted, healthy development of ovaries is supported, and the feed has a wider practical application value; meanwhile, the vitamin additive and the mineral additive can provide necessary trace elements and vitamins, and support normal metabolism, skeletal development, immune function and healthy development of ovaries of fishes.

This invention relates to a method for predicting key points of the internal skeleton based on plantar surface data, belonging to the field of computer vision. The method includes: acquiring an X-ray image of a patient's foot and labeling key points of the foot bones in the image; acquiring a depth map of the same patient's foot based on the camera viewpoint at the time of acquiring the X-ray image, and registering the edge contours of the X-ray image and the depth map to associate the labeled key points in the X-ray image with the features of the depth map; inputting the registered depth map into an improved YOLOv8-pose model to train the model, thereby enabling the model to predict key points of the foot bones based on the foot depth map. This invention can extract key points of the plantar bones in a faster, lower-cost, and non-invasive manner. These key points can be used to diagnose skeletal developmental disorders such as flat feet and high arches, and have significant clinical diagnostic value.

The invention relates to the technical field of feed, in particular to application of inulin in improving the laying rate of laying hens and feed efficiency. The laying rate and the feed conversion efficiency are remarkably improved, the laying period is prolonged, meanwhile, the slaughter rate is improved, and the breeding cost is reduced; the eggshell color and structure are adjusted, the eggshell thickness and strength are improved, the egg yolk nutrition index is synchronously improved, and the market competitiveness is enhanced; the serum hormone level is adjusted, the immune response and antioxidant capacity are enhanced, oxidative stress injury is reduced, and the health of chicken flocks is guaranteed; skeletal development and mineral deposition are promoted, serum uric acid and triglyceride levels are adjusted, and metabolic diseases are prevented; the intestinal structure is optimized, the yield of short-chain fatty acid is increased, the content of unsaturated fatty acid in egg yolk is increased, and the flavor and nutritional value of the product are improved; the antibiotic dependence is reduced through a natural substitution mechanism, the trend of green breeding and food safety is met, and the sustainable development of the industry is promoted.

The utility model provides a mandibular push molar distalization device suitable for bony class III malocclusion, which comprises a tail end guide rail, a front end guide rail, a push rod and a sleeve type push spring, the tail end guide rail is fixed on the last tooth needing to be moved, the front end guide rail is fixed on canine teeth or first premolar teeth at the turning position of a dentition dental arch, and the push rod is fixed on the sleeve type push spring. A push rod is arranged between the tail end guide rail and the front end guide rail in a penetrating mode, a traction hook is arranged at the end, penetrating through the front end guide rail, of the push rod, a tail end blocking ball is arranged at the other end, penetrating through the tail end guide rail, of the push rod, a sleeve type push spring is movably connected between the tail end guide rail and the front end guide rail in a sleeved mode, and a free buckle for blocking and limiting the sleeve type push spring is arranged on the push rod. The traction hook is connected with a jaw anchorage component such as an anchorage nail through a rubber band. The mandibular molars can be pushed to the distal direction, the mandibular molars can be pushed to the distal direction, meanwhile, the mandibular molars can assist in promoting the development of the maxilla and inhibiting the development of the mandible for other clinical bony III-type malocclusion orthotic devices, the structure is scientific and reasonable, the mandibular molars are simple and practical, the mechanical analysis is simple and clear, the use comfort of a patient is high, and the orthotic effect is good.

The invention relates to the technical field of food, in particular to application of pecan oil in resisting Alzheimer's disease, reducing blood fat, softening blood vessels and promoting skeletal development. By establishing different zebrafish animal models and utilizing fluorescent staining observation, it is found that the hickory nut oil has the effects of improving memory, resisting Alzheimer's disease, reducing blood fat, resisting atherosclerosis, softening blood vessels, reducing blood pressure, increasing bone mineral density and promoting skeletal development, and development of the hickory nut oil, especially wild hickory nut oil, can be promoted.

The invention discloses an adaptive manufacturing method and system for an orbital orthotope, and the method comprises the steps: fusing a dental digital model of a patient and a tooth socket digital model of an invisible tooth socket into a merged model which reflects the dental state of the patient wearing the invisible tooth socket; according to the combined model, a corresponding accommodating tooth socket is generated in the orthodontic device main body base block to accommodate an invisible tooth socket, so that an orthodontic device model is generated, and the orbital orthodontic device obtained by pressing a diaphragm according to the orthodontic device model can be used after a patient wears the invisible tooth socket in an overlapping manner. Therefore, the orbital orthosis can be utilized to stimulate children's muscles to improve oral muscle functions and skeletal development, and additional orthodontic force can be provided to make up for the defects that the orthodontic force becomes weak and the occlusal relationship between upper and lower jawbones cannot be corrected due to the fact that the invisible tooth socket is prone to stress relaxation.

The invention discloses establishment and application of an epinephelus coioides frontal bone tissue osteoblast line, and relates to the technical field of biology. The cell line is an epinephelus coioides frontal bone tissue osteoblast line ECFBOB, the preservation number is CCTCC NO: C2025131, the cell line is derived from the frontal bone tissue of juvenile epinephelus coioides, and the cell line is established after tissue separation, primary culture by a dry pasting method, subculture and cryopreservation resuscitation. The obtained cell line can be used as an in-vitro research model, provides a key technical tool for saddletail grouper improved variety breeding and healthy culture in saddletail grouper skeletal development mechanism analysis, osteogenesis-related gene function verification, craniofacial bone malformation cause research and species traceability verification, fills the blank of saddletail grouper bone tissue cell lines, and has a wide application prospect. The method has important scientific research value and industrial application prospect.