94 results about "Bone development" patented technology

The present invention relates to a nutritional composition, food and pharmaceutical products comprising the nutritional composition, and uses thereof. The nutritional composition comprises medium and long chain fatty acid triglycerides and breast milk oligosaccharides, and the weight ratio of the medium and long chain fatty acid triglycerides to the breast milk oligosaccharides is 1: 1 to 9: 1. The nutritional composition disclosed by the invention can play a role in synergistically promoting skeletal development and particularly improving bone mineral density.

The invention provides a nutritional composition and application of the nutritional composition. The nutritional composition comprises medium-chain and long-chain fatty acid triglyceride and a milk fat globule membrane in a mass ratio of (2: 1)-(97: 1), and the medium-chain and long-chain fatty acid triglyceride and the milk fat globule membrane have a synergistic effect in the aspects of promoting skeletal development, especially increasing bone mineral density and / or preventing or treating osteogenesis insufficiency and / or osteoporosis.

The invention provides a plant lactobacillus for promoting skeletal development in a growth period as well as application and a product of the plant lactobacillus, and belongs to the technical field of microorganisms. The invention provides a lactobacillus plantarum BL25 and a probiotic preparation thereof, the preservation number of the lactobacillus plantarum BL25 is CGMCC (China General Microbiological Culture Collection Center) No.33117, stachyose is adopted as prebiotics, and compared with other prebiotics, the lactobacillus plantarum BL25 can obviously promote the activity of the lactobacillus plantarum BL25. The plant lactobacillus BL25 and the probiotic preparation thereof have the effect of resisting the severe environment of gastrointestinal tracts, and can increase the length of femur and bone density, promote the development of a bone microstructure, improve bone metabolism, increase osteogenesis markers and reduce osteoclast markers, so that the skeletal development in the life growth period is promoted.

The invention relates to a nutritional composition, a food containing the nutritional composition and application of the nutritional composition. The nutritional composition comprises medium-chain and long-chain fatty acid triglyceride and nervonic acid, and the medium-chain and long-chain fatty acid triglyceride and the nervonic acid have a synergistic effect in the aspects of improving skeletal development and / or preventing or treating bone diseases.

The invention provides a method for constructing a skeleton prediction model based on an ROI-HU database and application, image segmentation is performed based on skeleton CT image data of different age groups, and a corresponding ROI-HU database is constructed based on pixel data of a constructed ROI region and an extracted Hu value. Regression training is carried out based on data features in a database, and a skeleton prediction model is constructed and can be used for predicting skeleton attributes of skeletons of patients at different age groups. According to the method, the patient can know the bone mineral density value of the corresponding age group, and can predict the bone attribute of the next stage, so that the patient can conveniently track and know the own bone development state in time. The bone attribute prediction is carried out based on the two indexes, meanwhile, the patient can know whether the bone of the patient has lesions or not, treatment can be carried out in time, and the prediction accuracy is improved.

The invention provides a milk powder composition containing breast milk oligosaccharide and easy to digest and absorb. The milk powder composition comprises the breast milk oligosaccharide, OPN, galactooligosaccharide, lactoferrin, alpha-whey protein, multivitamins, lactose, vegetable oil and compound minerals, wherein the weight ratio of the lactoferrin to the OPN to the breast milk oligosaccharide to the galactooligosaccharide is 1: (2-4): (2-50): (4-100). The composition can effectively recover and improve the intestinal barrier function caused by inflammatory factors, can be well absorbed by infants with poor digestion and absorption functions, reduces diarrhea and promotes skeletal development.

The invention relates to the technical field of microorganisms, and particularly discloses bifidobacterium adolescentis AGE17 capable of promoting growth and development of muscles and bones and application of the bifidobacterium adolescentis AGE17. The bifidobacterium adolescentis AGE17 is separated from excrement of healthy children and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.33452, and the preservation date is January 17, 2025. The bifidobacterium adolescentis AGE17 has the advantages that the bifidobacterium adolescentis AGE17 can be used for preparing the biological organic fertilizer; animal experiments prove that the bifidobacterium adolescentis strain AGE17 provided by the invention has the function of promoting muscle and skeletal development, has more obvious and prominent effects compared with a model strain bifidobacterium adolescentis ATCC15703, and has important application value in increasing the muscle strength and height of children and adolescents.

The invention discloses a composition for promoting growth and development and application thereof, and relates to the technical field of nutritional compositions. The invention provides a composition for promoting growth and development, the composition is composed of milk mineral salt, colostrum basic protein and hydrolyzed egg yolk powder, and the mass ratio of the milk mineral salt to the colostrum basic protein to the hydrolyzed egg yolk powder is (14-22): (5-10): 1. The composition provided by the invention can promote growth and development, can increase the fluorescence intensity of the skull of the zebra fish and increase the body length of the zebra fish, and has an obvious effect on promoting skeletal development and body development.

The invention provides a preparation method of yak bone collagen peptide, a composition for promoting skeletal development and application of the composition, and relates to the technical field of health food. The preparation method comprises the following steps: carrying out ultrasonic pretreatment on yak bones, and degreasing through supercritical CO2 to obtain a degreased product; mixing the degreased product with a fishy smell removing agent to obtain a fishy smell removing product; the fishy smell removing agent is an aqueous solution of a plant extract; the plant extract is selected from at least one of amomum tsao-ko extract, turmeric extract, green tea extract or momordica grosvenori extract; the fishy smell removal product is subjected to an enzymatic hydrolysis reaction through an immobilized compound enzyme reactor, wherein the compound enzyme is prolyl endopeptidase, papain and ficin; obtaining a crude product; carrying out ultrafiltration by adopting a filter membrane with the molecular weight cut-off of 1kDa, and adsorbing through macroporous resin. The yak bone collagen peptide and the composition prepared by the invention can obviously improve the body length, promote the skeletal development and promote the secretion of growth hormone, and meet the growth requirements of children.

The invention relates to the field of food, in particular to colostrum basic protein as well as a preparation method and application thereof. The colostrum basic protein of the present invention can increase bone mass, increase bone density, promote skeletal development, promote skeletal regeneration or repair, promote calcium absorption, promote bone collagen production, and / or prevent and / or treat bone related diseases (such as osteoporosis, osteoporosis, rickets, osteoarthrosis).

The application discloses a flavonoid compound in eaglewood as well as a preparation method and application of the flavonoid compound, and relates to the technical field of medicines. The application extracts and separates a new compound from natural eaglewood, and the new compound is used in the preparation of anti-osteoporosis drugs. The compound is detected in vitro to obtain an induction effect of the compound on the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts, so as to affect the formation of osteoclasts. Meanwhile, the compound can promote the bone development of zebra fish through RT-qPCR detection, which indicates that the compound has anti-osteoporosis activity. The separation method of the compound is simple and easy to operate.

The invention discloses sturgeon cartilage active peptide capable of promoting growth and improving bone development as well as a preparation method and application of the sturgeon cartilage active peptide, and belongs to the technical field of active peptide. According to the invention, sturgeon cartilage is taken as a raw material, polypeptide with the highest activity of promoting bone growth and development is selected from different enzymolysis combinations through MC3T3-E1 cell tests, and the positive effect of the polypeptide is verified through zebra fish tests; then, two potential sturgeon cartilage active peptide sequences with the function of promoting bone growth and development are screened out through bioinformatics technologies such as mass spectrum identification, molecular docking and the like, and the amino acid sequences of the sturgeon cartilage active peptide fragments are shown as SEQ ID NO.2 and SEQ ID NO.5. The sturgeon cartilage peptide prepared by the method disclosed by the invention has the activity of promoting bone growth and development, can solve the problem of high-value utilization of sturgeons, can also be applied to functional products as a functional factor, and has a good application prospect.

The invention relates to an application of plant lactobacillus Hi188 in promotion of bone health. The invention provides the application of the plant lactobacillus Hi188 or the afterbiogen thereof or the composition thereof in increasing the bone mineral density, increasing the bone mineral density, promoting the skeletal development, increasing the bone mineral content and / or promoting the tibia growth. Or preparing food for increasing bone mineral density, increasing bone mineral density, promoting skeletal development, increasing bone mineral content and / or promoting tibia growth; wherein the composition comprises: (A) Phytobacterium plantarum Hi188 or a postbiotic thereof, and (B) Bifidobacterium lactis Ca360 or a postbiotic thereof.

The utility model provides a bone anchorage type maxillary distraction osteogenesis device which comprises a spiral expansion device, and a rear base plate of the spiral expansion device is fixed to the rear half section of the maxillary bone through a left anchorage nail and a right anchorage nail. The front base plate and the rear base plate are respectively connected with at least two belt rings through belt ring connecting rods, the left front belt ring and the right front belt ring connected with the front base plate are at least sleeved on the first front molars on the corresponding sides, and the left rear belt ring and the right rear belt ring connected with the rear base plate are sleeved on the first molars and / or the second molars on the corresponding sides; the two front band rings are connected through a labial arch, and a lip baffle is fixed in the middle of the labial arch; a traction hook matched with a front tractor is fixedly connected to the outer ring face of the rear belt ring. According to the utility model, the osteotomy gap between the first premolar and the second premolar can be stably and effectively stretched, so that the aim of correcting skeletal hypoplasia or repairing bone defects is fulfilled.

The invention relates to the technical field of active peptides, and discloses a yolk-derived active peptide for promoting bone growth and a preparation method thereof. The preparation method comprises the following steps: cleaning, selecting, sterilizing and drying poultry eggs to obtain sterile poultry eggs; performing spray drying on yolk to obtain yolk powder, and performing degreasing treatment to obtain degreased yolk powder; sieving the degreased egg yolk powder, and adding deionized water to obtain a degreased egg yolk powder suspension; adjusting the pH and temperature of the degreased yolk powder suspension, and performing enzymolysis to obtain enzymatic hydrolysate; inactivating the enzymatic hydrolysate for later use; adding calcium lactate and zinc lactate into the enzymatic hydrolysate, adding geobacillus stearothermophilus, and fermenting to obtain fermentation liquor; separating to obtain an active peptide solution. According to the yolk-sourced active peptide for promoting bone growth and the preparation method, the active peptide with small molecular weight is obtained through distributed enzymolysis and fermentation and is easy to absorb, and calcium ions and zinc ions are added during fermentation, so that the active peptide is chelated with metal ions, and growth and bone development are promoted.

The invention belongs to the technical field of biology, and particularly relates to a construction method of epigenome edited zebrafish, sgRNA of a targeted zebrafish runx2b gene promoter region and application of the sgRNA. The invention provides a construction method of epigenome edited zebrafish, which comprises the step of carrying out methylation editing by using a CRISPR / dCas9-methyltransferase system targeting runx2b gene promoter region, thereby inhibiting runx2b gene expression and reducing intermuscular bone formation. According to the method, the expression level of the runx2b gene is accurately regulated and controlled through an epigenetic editing technology on the premise that a DNA sequence is not changed, and formation of fish intermuscular bones is effectively reduced. The zebra fish F0 treated by the method represents that the runx2b mRNA expression level is obviously reduced, and the intermuscular bones of the eleventh to sixteenth sarcomedo regions of adult F0 generation fish are obviously shorter than those of a control group, and the shortening range reaches 23.3% to 38.8%. Besides, the method provides theoretical basis and technical support for improving fish economic traits by accurately regulating and controlling the expression mode of the key economic trait gene and simultaneously keeping the integrity of genome DNA (Deoxyribose Nucleic Acid).

The invention provides a kit and a method for evaluating and / or predicting skeletal development conditions. The kit comprises a reagent for detecting the sulfate content, and the sulfate content serves as a biomarker of the skeletal development condition. The sulfate content is used as the biomarker for evaluating and / or predicting the skeletal development condition, and the biomarker has the advantages of high sensitivity, high specificity, low detection cost, convenience in material taking, easiness in sample storage and the like, can be widely applied to related work such as health examination and disease general survey, and becomes an effective means for growth and development evaluation and auxiliary disease diagnosis. Moreover, the biomarker disclosed by the invention has the characteristics that the smaller the age (before adolescence) is, the higher the correlation is, so that the higher the sensitivity is, which means that the biomarker disclosed by the invention can be used for effectively evaluating and / or predicting the skeletal development condition, and identifying and intervening diseases earlier, and is more likely to improve the final height of a patient with short stature.

This invention discloses a method for in-situ preparation of calcium chelate peptides that promote intestinal calcium absorption and osteoblast development from fish scales using high-pressure homogenization-assisted enzymatic hydrolysis. The method uses fish scales as raw material, which are pulverized and then pretreated with high-pressure homogenization to break down the dense cross-linked structure of the scales. Pepsin is used as the hydrolytic enzyme to achieve efficient enzymatic hydrolysis of collagen and in-situ chelation with natural calcium, resulting in a one-step preparation of collagen calcium chelate peptides. The product has a calcium retention rate of ≥84.16%, is rich in affinity amino acids, and shows a ≥62.97% increase in calcium transport compared to calcium chloride in a small intestinal epithelial cell absorption and transport model, while being safe and non-cytotoxic. This invention is a green and efficient process that eliminates the need for decalcification steps, achieving a collagen calcium chelate peptide yield of ≥83.4%. It realizes the high-value utilization of aquatic by-products and can be directly applied to various calcium supplements such as food and health products that enhance intestinal calcium absorption and promote bone development, solving problems such as low bioavailability of traditional calcium preparations and severe calcium loss in existing fish scale utilization processes.

The present invention relates to the field of microorganisms, and in particular to a strain of anaerobic fecal coryneform bacteria CML199, a biological preparation and its application in preparing products for improving the performance of laying hens. The present invention has discovered a new anaerobic fecal coryneform bacteria (Anaerostipes caccae) CML199 without toxic side effects, and its preservation number is CGMCC No.31340. The anaerobic fecal coryneform bacteria can promote the bone development of laying hens, increase the level of bone formation markers in the femur, increase the level of bone formation markers in serum, improve the bone marrow immune microenvironment, and improve the eggshell quality. It is expected to be developed into a new and effective probiotic preparation, and has a very broad application prospect in the laying hen industry.

The application relates to the field of microbial technology, and particularly discloses a Bifidobacterium adolescentis AGE17 for promoting muscle and bone growth and development and an application thereof. Bifidobacterium adolescentis The Bifidobacterium adolescentis AGE17 is isolated from the feces of healthy children, is preserved in the China General Microbiological Culture Collection Center, and has a preservation number of CGMCC No. 33452 and a preservation date of January 17, 2025. Animal experiments prove that the Bifidobacterium adolescentis strain AGE17 provided by the application has the function of promoting muscle and bone development, has more obvious and prominent effects compared with a model strain Bifidobacterium adolescentis ATCC15703, and has important application values in increasing the muscle strength and height of children and teenagers.

The invention discloses a special feed for black pigs. The special feed is characterized by comprising the following raw materials: corn, fermented soybean meal, bran, sweet potato vine powder, fish meal, chicken intestine membrane protein powder, composite vitamins, composite minerals, lysine, methionine, table salt and a probiotic preparation. The preparation method of the special feed for the black pigs is characterized by comprising the following steps: S1, pretreating the raw materials; s2, mixing and stirring for the first time; s3, mixing and stirring for the second time; s4, mixing and stirring for the third time; and S5, drying. Aiming at the physiological characteristics of long growth cycle, mild energy and protein requirements and high dietary fiber and mineral substance requirements of black pigs, all the raw material components are accurately proportioned, so that the black pig feed is easier to digest and absorb, reduces the burden of gastrointestinal tracts, promotes intestinal peristalsis, improves the digestive function, meets the requirements of skeletal development and muscle growth, avoids deficiency or excess of micronutrients, and improves the production efficiency. The intestinal flora balance can be adjusted, and the immunity is improved.

The invention discloses a bone development capability evaluation method and device, and relates to the technical field of image processing, and the method comprises the steps: receiving a preset bone X-ray image of a target user, and extracting key features of bone growth; calling a pre-trained bone development capability evaluation model to analyze the bone growth key features, and generating an initial bone development evaluation result; and acquiring preset bone use information of the target user, comparing the preset bone use information with the model sample parameters, correcting an evaluation result by configuring a feedback coefficient, and generating a personalized target bone development evaluation report. The technical problems that an existing bone development assessment method is high in subjectivity, insufficient in individual difference consideration and lack of a dynamic correction mechanism, and consequently the assessment accuracy and the individuation degree are low are solved, and the purpose that the assessment accuracy and the individuation degree are improved by combining automatic image analysis, individualized bone use information and the correction mechanism is achieved. And the accuracy, individuation and reliability of bone development evaluation are improved.

This invention relates to a nutritional composition for promoting bone development and its applications. The invention provides applications of the nutritional composition or preparations comprising said nutritional composition, including: (1) preparing food products; (2) preparing health products for promoting bone development, increasing height, and / or improving bone density; (3) preparing drugs or drug compositions for promoting bone development, increasing height, increasing bone density, treating or preventing osteoporosis, and / or treating or preventing skeletal dysplasia; and (4) promoting bone development, increasing height, and / or improving bone density for non-therapeutic purposes; wherein said nutritional composition comprises medium- and long-chain triglycerides (MLCT) and 1,3-diunsaturated fatty acid-2-palmitoyltriglycerides (UPU).

The invention provides mixed structure grease for promoting skeletal development and improving bone mineral density as well as a preparation method and application of the mixed structure grease. The mixed structure grease for promoting skeletal development and improving bone mineral density comprises the following components in percentage by mass: 2-10% of medium-chain fatty acid triglyceride, 10-50% of medium-long-chain fatty acid triglyceride and 40-90% of long-chain fatty acid triglyceride. The traditional Chinese medicine composition can effectively promote skeletal development and improve bone mineral density.

An orthopedic system and method for treating a femoral fracture in, for example, a skeletally immature patient. The system and method including an intramedullary nail arranged and configured to be implanted within, for example, a femur of a skeletally immature patient. The system and method further including a bone screw (100) including a distal region (110) and a proximal region (130), wherein the distal region (110) is devoid of any threads so that the patient's bone is free to grow overtime.

The invention discloses a construction method and application of an adriamycin-induced zebrafish osteoporosis-like model, and the construction method comprises the following steps: by utilizing the characteristics of transparency and rapid bone development of zebrafish embryos and juvenile fishes, selecting the zebrafish embryos of 2dpf, and culturing the zebrafish embryos to 6dpf in an adriamycin aqueous solution of 20 mu m, so as to obtain the adriamycin-induced zebrafish osteoporosis-like model. Therefore, the visual zebrafish osteoporosis-like model is efficiently constructed, juvenile fish bodies are transparent, imaging is visual, bone development changes can be observed in vivo in real time, and visual evaluation of bone development injuries is achieved. The built zebrafish osteoporosis-like model clearly shows the systematic inhibition effect of chemotherapy drugs on bone formation and mineralization, has the advantages of being short in building period, easy and convenient to operate, high in repeatability and sensitive to drug reaction, can be used for rapid dose screening and intervention experiments, and has good application prospects. The method has great application potential in research of pathogenesis of CIOP, screening of anti-osteoporosis drugs and evaluation of curative effect of the anti-osteoporosis drugs.

This invention discloses an active peptide from sturgeon cartilage that promotes height growth and improves bone development, along with its preparation method and applications, belonging to the field of active peptide technology. Using sturgeon cartilage as raw material, this invention selects the polypeptide with the highest activity in promoting bone growth and development from different enzymatic hydrolysis combinations through MC3T3-E1 cell experiments, and verifies its positive effect using zebrafish experiments. Subsequently, two potential active peptide sequences from sturgeon cartilage with bone growth and development promotion functions are screened using mass spectrometry to identify their sequences and bioinformatics techniques such as molecular docking. The amino acid sequences of the active peptide segments are shown in SEQ ID NO.2 and SEQ ID NO.5. The sturgeon cartilage peptides prepared by this invention have activity in promoting bone growth and development, which can solve the problem of high-value utilization of sturgeon and can also be used as a functional factor in functional products, showing good application prospects.

The present invention belongs to the field of microbial technology, and specifically relates to a Lactobacillus reuteri that can promote mineral absorption and improve bone metabolism, and its products and applications. Lactobacillus reuteri LR-01, deposited with the General Microbiology Center of the China National Committee for the Administration of Microbiological Culture Collection, under the accession number CGMCC No. 17754, was deposited on May 10, 2019. The Lactobacillus reuteri LR-01 provided by the present invention can balance height and weight, promote physical development in children, enhance mineral absorption, increase mineral bioavailability, improve bone metabolism, and promote healthy bone development. It has broad application prospects in the preparation of products that promote growth and development and nutrient absorption.

The present invention provides a method and application for constructing a bone prediction model based on a ROI-HU database, performing image segmentation based on bone CT image data of different age groups, and constructing a corresponding ROI-HU database based on the pixel data of the constructed ROI area and the extracted Hu value. Regression training is performed based on the data features in the database to construct a bone prediction model, which can be used to predict the bone properties of patients' bones in different age groups. Patients can understand the bone density value they should have in the corresponding age group, and can predict the bone properties they should have in the next stage, so that patients can track and understand their own bone development status in a timely manner. The prediction of bone properties is based on two indicators, and patients can also be informed of factors such as whether their bones have lesions, so that they can start treatment in time and improve the accuracy of prediction.

The present invention relates to a nutritional composition, a food and a medicine comprising the nutritional composition, and their uses. The nutritional composition comprises medium and long chain fatty acid triglycerides and human milk oligosaccharides, and the weight ratio of the medium and long chain fatty acid triglycerides to the human milk oligosaccharides is 1:1 to 9:1. The nutritional composition of the present invention can synergistically promote bone development, particularly improve bone density.