57 results about "Bone development" patented technology

The invention provides a preparation method of yak bone collagen peptide, a composition for promoting skeletal development and application of the composition, and relates to the technical field of health food. The preparation method comprises the following steps: carrying out ultrasonic pretreatment on yak bones, and degreasing through supercritical CO2 to obtain a degreased product; mixing the degreased product with a fishy smell removing agent to obtain a fishy smell removing product; the fishy smell removing agent is an aqueous solution of a plant extract; the plant extract is selected from at least one of amomum tsao-ko extract, turmeric extract, green tea extract or momordica grosvenori extract; the fishy smell removal product is subjected to an enzymatic hydrolysis reaction through an immobilized compound enzyme reactor, wherein the compound enzyme is prolyl endopeptidase, papain and ficin; obtaining a crude product; carrying out ultrafiltration by adopting a filter membrane with the molecular weight cut-off of 1kDa, and adsorbing through macroporous resin. The yak bone collagen peptide and the composition prepared by the invention can obviously improve the body length, promote the skeletal development and promote the secretion of growth hormone, and meet the growth requirements of children.

The application discloses a flavonoid compound in eaglewood as well as a preparation method and application of the flavonoid compound, and relates to the technical field of medicines. The application extracts and separates a new compound from natural eaglewood, and the new compound is used in the preparation of anti-osteoporosis drugs. The compound is detected in vitro to obtain an induction effect of the compound on the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts, so as to affect the formation of osteoclasts. Meanwhile, the compound can promote the bone development of zebra fish through RT-qPCR detection, which indicates that the compound has anti-osteoporosis activity. The separation method of the compound is simple and easy to operate.

The invention discloses sturgeon cartilage active peptide capable of promoting growth and improving bone development as well as a preparation method and application of the sturgeon cartilage active peptide, and belongs to the technical field of active peptide. According to the invention, sturgeon cartilage is taken as a raw material, polypeptide with the highest activity of promoting bone growth and development is selected from different enzymolysis combinations through MC3T3-E1 cell tests, and the positive effect of the polypeptide is verified through zebra fish tests; then, two potential sturgeon cartilage active peptide sequences with the function of promoting bone growth and development are screened out through bioinformatics technologies such as mass spectrum identification, molecular docking and the like, and the amino acid sequences of the sturgeon cartilage active peptide fragments are shown as SEQ ID NO.2 and SEQ ID NO.5. The sturgeon cartilage peptide prepared by the method disclosed by the invention has the activity of promoting bone growth and development, can solve the problem of high-value utilization of sturgeons, can also be applied to functional products as a functional factor, and has a good application prospect.

The invention relates to an application of plant lactobacillus Hi188 in promotion of bone health. The invention provides the application of the plant lactobacillus Hi188 or the afterbiogen thereof or the composition thereof in increasing the bone mineral density, increasing the bone mineral density, promoting the skeletal development, increasing the bone mineral content and / or promoting the tibia growth. Or preparing food for increasing bone mineral density, increasing bone mineral density, promoting skeletal development, increasing bone mineral content and / or promoting tibia growth; wherein the composition comprises: (A) Phytobacterium plantarum Hi188 or a postbiotic thereof, and (B) Bifidobacterium lactis Ca360 or a postbiotic thereof.

The utility model provides a bone anchorage type maxillary distraction osteogenesis device which comprises a spiral expansion device, and a rear base plate of the spiral expansion device is fixed to the rear half section of the maxillary bone through a left anchorage nail and a right anchorage nail. The front base plate and the rear base plate are respectively connected with at least two belt rings through belt ring connecting rods, the left front belt ring and the right front belt ring connected with the front base plate are at least sleeved on the first front molars on the corresponding sides, and the left rear belt ring and the right rear belt ring connected with the rear base plate are sleeved on the first molars and / or the second molars on the corresponding sides; the two front band rings are connected through a labial arch, and a lip baffle is fixed in the middle of the labial arch; a traction hook matched with a front tractor is fixedly connected to the outer ring face of the rear belt ring. According to the utility model, the osteotomy gap between the first premolar and the second premolar can be stably and effectively stretched, so that the aim of correcting skeletal hypoplasia or repairing bone defects is fulfilled.

The invention relates to the technical field of active peptides, and discloses a yolk-derived active peptide for promoting bone growth and a preparation method thereof. The preparation method comprises the following steps: cleaning, selecting, sterilizing and drying poultry eggs to obtain sterile poultry eggs; performing spray drying on yolk to obtain yolk powder, and performing degreasing treatment to obtain degreased yolk powder; sieving the degreased egg yolk powder, and adding deionized water to obtain a degreased egg yolk powder suspension; adjusting the pH and temperature of the degreased yolk powder suspension, and performing enzymolysis to obtain enzymatic hydrolysate; inactivating the enzymatic hydrolysate for later use; adding calcium lactate and zinc lactate into the enzymatic hydrolysate, adding geobacillus stearothermophilus, and fermenting to obtain fermentation liquor; separating to obtain an active peptide solution. According to the yolk-sourced active peptide for promoting bone growth and the preparation method, the active peptide with small molecular weight is obtained through distributed enzymolysis and fermentation and is easy to absorb, and calcium ions and zinc ions are added during fermentation, so that the active peptide is chelated with metal ions, and growth and bone development are promoted.

The invention belongs to the technical field of biology, and particularly relates to a construction method of epigenome edited zebrafish, sgRNA of a targeted zebrafish runx2b gene promoter region and application of the sgRNA. The invention provides a construction method of epigenome edited zebrafish, which comprises the step of carrying out methylation editing by using a CRISPR / dCas9-methyltransferase system targeting runx2b gene promoter region, thereby inhibiting runx2b gene expression and reducing intermuscular bone formation. According to the method, the expression level of the runx2b gene is accurately regulated and controlled through an epigenetic editing technology on the premise that a DNA sequence is not changed, and formation of fish intermuscular bones is effectively reduced. The zebra fish F0 treated by the method represents that the runx2b mRNA expression level is obviously reduced, and the intermuscular bones of the eleventh to sixteenth sarcomedo regions of adult F0 generation fish are obviously shorter than those of a control group, and the shortening range reaches 23.3% to 38.8%. Besides, the method provides theoretical basis and technical support for improving fish economic traits by accurately regulating and controlling the expression mode of the key economic trait gene and simultaneously keeping the integrity of genome DNA (Deoxyribose Nucleic Acid).

This invention discloses a method for in-situ preparation of calcium chelate peptides that promote intestinal calcium absorption and osteoblast development from fish scales using high-pressure homogenization-assisted enzymatic hydrolysis. The method uses fish scales as raw material, which are pulverized and then pretreated with high-pressure homogenization to break down the dense cross-linked structure of the scales. Pepsin is used as the hydrolytic enzyme to achieve efficient enzymatic hydrolysis of collagen and in-situ chelation with natural calcium, resulting in a one-step preparation of collagen calcium chelate peptides. The product has a calcium retention rate of ≥84.16%, is rich in affinity amino acids, and shows a ≥62.97% increase in calcium transport compared to calcium chloride in a small intestinal epithelial cell absorption and transport model, while being safe and non-cytotoxic. This invention is a green and efficient process that eliminates the need for decalcification steps, achieving a collagen calcium chelate peptide yield of ≥83.4%. It realizes the high-value utilization of aquatic by-products and can be directly applied to various calcium supplements such as food and health products that enhance intestinal calcium absorption and promote bone development, solving problems such as low bioavailability of traditional calcium preparations and severe calcium loss in existing fish scale utilization processes.

The application relates to the field of microbial technology, and particularly discloses a Bifidobacterium adolescentis AGE17 for promoting muscle and bone growth and development and an application thereof. Bifidobacterium adolescentis The Bifidobacterium adolescentis AGE17 is isolated from the feces of healthy children, is preserved in the China General Microbiological Culture Collection Center, and has a preservation number of CGMCC No. 33452 and a preservation date of January 17, 2025. Animal experiments prove that the Bifidobacterium adolescentis strain AGE17 provided by the application has the function of promoting muscle and bone development, has more obvious and prominent effects compared with a model strain Bifidobacterium adolescentis ATCC15703, and has important application values in increasing the muscle strength and height of children and teenagers.

The invention discloses a special feed for black pigs. The special feed is characterized by comprising the following raw materials: corn, fermented soybean meal, bran, sweet potato vine powder, fish meal, chicken intestine membrane protein powder, composite vitamins, composite minerals, lysine, methionine, table salt and a probiotic preparation. The preparation method of the special feed for the black pigs is characterized by comprising the following steps: S1, pretreating the raw materials; s2, mixing and stirring for the first time; s3, mixing and stirring for the second time; s4, mixing and stirring for the third time; and S5, drying. Aiming at the physiological characteristics of long growth cycle, mild energy and protein requirements and high dietary fiber and mineral substance requirements of black pigs, all the raw material components are accurately proportioned, so that the black pig feed is easier to digest and absorb, reduces the burden of gastrointestinal tracts, promotes intestinal peristalsis, improves the digestive function, meets the requirements of skeletal development and muscle growth, avoids deficiency or excess of micronutrients, and improves the production efficiency. The intestinal flora balance can be adjusted, and the immunity is improved.

This invention relates to a nutritional composition for promoting bone development and its applications. The invention provides applications of the nutritional composition or preparations comprising said nutritional composition, including: (1) preparing food products; (2) preparing health products for promoting bone development, increasing height, and / or improving bone density; (3) preparing drugs or drug compositions for promoting bone development, increasing height, increasing bone density, treating or preventing osteoporosis, and / or treating or preventing skeletal dysplasia; and (4) promoting bone development, increasing height, and / or improving bone density for non-therapeutic purposes; wherein said nutritional composition comprises medium- and long-chain triglycerides (MLCT) and 1,3-diunsaturated fatty acid-2-palmitoyltriglycerides (UPU).

The invention provides mixed structure grease for promoting skeletal development and improving bone mineral density as well as a preparation method and application of the mixed structure grease. The mixed structure grease for promoting skeletal development and improving bone mineral density comprises the following components in percentage by mass: 2-10% of medium-chain fatty acid triglyceride, 10-50% of medium-long-chain fatty acid triglyceride and 40-90% of long-chain fatty acid triglyceride. The traditional Chinese medicine composition can effectively promote skeletal development and improve bone mineral density.

The invention discloses a construction method and application of an adriamycin-induced zebrafish osteoporosis-like model, and the construction method comprises the following steps: by utilizing the characteristics of transparency and rapid bone development of zebrafish embryos and juvenile fishes, selecting the zebrafish embryos of 2dpf, and culturing the zebrafish embryos to 6dpf in an adriamycin aqueous solution of 20 mu m, so as to obtain the adriamycin-induced zebrafish osteoporosis-like model. Therefore, the visual zebrafish osteoporosis-like model is efficiently constructed, juvenile fish bodies are transparent, imaging is visual, bone development changes can be observed in vivo in real time, and visual evaluation of bone development injuries is achieved. The built zebrafish osteoporosis-like model clearly shows the systematic inhibition effect of chemotherapy drugs on bone formation and mineralization, has the advantages of being short in building period, easy and convenient to operate, high in repeatability and sensitive to drug reaction, can be used for rapid dose screening and intervention experiments, and has good application prospects. The method has great application potential in research of pathogenesis of CIOP, screening of anti-osteoporosis drugs and evaluation of curative effect of the anti-osteoporosis drugs.

This invention discloses an active peptide from sturgeon cartilage that promotes height growth and improves bone development, along with its preparation method and applications, belonging to the field of active peptide technology. Using sturgeon cartilage as raw material, this invention selects the polypeptide with the highest activity in promoting bone growth and development from different enzymatic hydrolysis combinations through MC3T3-E1 cell experiments, and verifies its positive effect using zebrafish experiments. Subsequently, two potential active peptide sequences from sturgeon cartilage with bone growth and development promotion functions are screened using mass spectrometry to identify their sequences and bioinformatics techniques such as molecular docking. The amino acid sequences of the active peptide segments are shown in SEQ ID NO.2 and SEQ ID NO.5. The sturgeon cartilage peptides prepared by this invention have activity in promoting bone growth and development, which can solve the problem of high-value utilization of sturgeon and can also be used as a functional factor in functional products, showing good application prospects.

The present invention belongs to the field of microbial technology, and specifically relates to a Lactobacillus reuteri that can promote mineral absorption and improve bone metabolism, and its products and applications. Lactobacillus reuteri LR-01, deposited with the General Microbiology Center of the China National Committee for the Administration of Microbiological Culture Collection, under the accession number CGMCC No. 17754, was deposited on May 10, 2019. The Lactobacillus reuteri LR-01 provided by the present invention can balance height and weight, promote physical development in children, enhance mineral absorption, increase mineral bioavailability, improve bone metabolism, and promote healthy bone development. It has broad application prospects in the preparation of products that promote growth and development and nutrient absorption.

The invention relates to the use of a microbiota-modulating agent for enhancing bone development and / or bone strength. wherein the microbiota-modulating agent modulates the abundance of one or more bacterial taxa selected from Intestinimonas butyriciproducens, Turicibacter sanguinis, Paraprevotella clara, and Acidaminococcaceae in the gut of the subject.

The invention relates to the technical field of feeds, and discloses a mystus guttatus feed and a preparation method thereof, the mystus guttatus feed comprises the following raw materials by mass: 25-32 parts of fish meal, 20-25 parts of soybean meal, 30-35 parts of corn flour, 5-8 parts of fish oil, 1-2 parts of spirulina powder, 0.5-1.5 parts of a vitamin additive, 1-3 parts of a mineral additive, and 0.3-2 parts of a Chinese herbal medicine additive; the Chinese herbal medicine additive comprises the following components in parts by mass: 10-20 parts of boxthorn leaves, 5-10 parts of astragalus stems and leaves, 9-11 parts of pericarpium citri reticulatae, 8-15 parts of angelica sinensis, 3-5 parts of longan aril and 1-2 parts of fructus aurantii. According to the scheme, Chinese herbal medicine components such as boxthorn leaves, astragalus membranaceus, pericarpium citri reticulatae, angelica sinensis, fructus aurantii and longan aril are added into the feed, so that the immunity of mystus guttatus can be remarkably improved, diseases are reduced, meanwhile, the physiological function of mystus guttatus can be adjusted, healthy development of ovaries is supported, and the feed has a wider practical application value; meanwhile, the vitamin additive and the mineral additive can provide necessary trace elements and vitamins, and support normal metabolism, skeletal development, immune function and healthy development of ovaries of fishes.

This invention relates to a method for predicting key points of the internal skeleton based on plantar surface data, belonging to the field of computer vision. The method includes: acquiring an X-ray image of a patient's foot and labeling key points of the foot bones in the image; acquiring a depth map of the same patient's foot based on the camera viewpoint at the time of acquiring the X-ray image, and registering the edge contours of the X-ray image and the depth map to associate the labeled key points in the X-ray image with the features of the depth map; inputting the registered depth map into an improved YOLOv8-pose model to train the model, thereby enabling the model to predict key points of the foot bones based on the foot depth map. This invention can extract key points of the plantar bones in a faster, lower-cost, and non-invasive manner. These key points can be used to diagnose skeletal developmental disorders such as flat feet and high arches, and have significant clinical diagnostic value.

The invention relates to the technical field of feed, in particular to application of inulin in improving the laying rate of laying hens and feed efficiency. The laying rate and the feed conversion efficiency are remarkably improved, the laying period is prolonged, meanwhile, the slaughter rate is improved, and the breeding cost is reduced; the eggshell color and structure are adjusted, the eggshell thickness and strength are improved, the egg yolk nutrition index is synchronously improved, and the market competitiveness is enhanced; the serum hormone level is adjusted, the immune response and antioxidant capacity are enhanced, oxidative stress injury is reduced, and the health of chicken flocks is guaranteed; skeletal development and mineral deposition are promoted, serum uric acid and triglyceride levels are adjusted, and metabolic diseases are prevented; the intestinal structure is optimized, the yield of short-chain fatty acid is increased, the content of unsaturated fatty acid in egg yolk is increased, and the flavor and nutritional value of the product are improved; the antibiotic dependence is reduced through a natural substitution mechanism, the trend of green breeding and food safety is met, and the sustainable development of the industry is promoted.

The utility model provides a mandibular push molar distalization device suitable for bony class III malocclusion, which comprises a tail end guide rail, a front end guide rail, a push rod and a sleeve type push spring, the tail end guide rail is fixed on the last tooth needing to be moved, the front end guide rail is fixed on canine teeth or first premolar teeth at the turning position of a dentition dental arch, and the push rod is fixed on the sleeve type push spring. A push rod is arranged between the tail end guide rail and the front end guide rail in a penetrating mode, a traction hook is arranged at the end, penetrating through the front end guide rail, of the push rod, a tail end blocking ball is arranged at the other end, penetrating through the tail end guide rail, of the push rod, a sleeve type push spring is movably connected between the tail end guide rail and the front end guide rail in a sleeved mode, and a free buckle for blocking and limiting the sleeve type push spring is arranged on the push rod. The traction hook is connected with a jaw anchorage component such as an anchorage nail through a rubber band. The mandibular molars can be pushed to the distal direction, the mandibular molars can be pushed to the distal direction, meanwhile, the mandibular molars can assist in promoting the development of the maxilla and inhibiting the development of the mandible for other clinical bony III-type malocclusion orthotic devices, the structure is scientific and reasonable, the mandibular molars are simple and practical, the mechanical analysis is simple and clear, the use comfort of a patient is high, and the orthotic effect is good.

The invention discloses an adaptive manufacturing method and system for an orbital orthotope, and the method comprises the steps: fusing a dental digital model of a patient and a tooth socket digital model of an invisible tooth socket into a merged model which reflects the dental state of the patient wearing the invisible tooth socket; according to the combined model, a corresponding accommodating tooth socket is generated in the orthodontic device main body base block to accommodate an invisible tooth socket, so that an orthodontic device model is generated, and the orbital orthodontic device obtained by pressing a diaphragm according to the orthodontic device model can be used after a patient wears the invisible tooth socket in an overlapping manner. Therefore, the orbital orthosis can be utilized to stimulate children's muscles to improve oral muscle functions and skeletal development, and additional orthodontic force can be provided to make up for the defects that the orthodontic force becomes weak and the occlusal relationship between upper and lower jawbones cannot be corrected due to the fact that the invisible tooth socket is prone to stress relaxation.

The invention discloses establishment and application of an epinephelus coioides frontal bone tissue osteoblast line, and relates to the technical field of biology. The cell line is an epinephelus coioides frontal bone tissue osteoblast line ECFBOB, the preservation number is CCTCC NO: C2025131, the cell line is derived from the frontal bone tissue of juvenile epinephelus coioides, and the cell line is established after tissue separation, primary culture by a dry pasting method, subculture and cryopreservation resuscitation. The obtained cell line can be used as an in-vitro research model, provides a key technical tool for saddletail grouper improved variety breeding and healthy culture in saddletail grouper skeletal development mechanism analysis, osteogenesis-related gene function verification, craniofacial bone malformation cause research and species traceability verification, fills the blank of saddletail grouper bone tissue cell lines, and has a wide application prospect. The method has important scientific research value and industrial application prospect.

The invention belongs to the technical field of microbial engineering, and discloses a composition for promoting skeletal development and application thereof, and the composition contains bifidobacterium longum subsp. Infantis i18, 2 '-fucosyllactose and lactose-N-neotetraose. All the components in the composition have a synergistic effect, the content of calcium ions in bone cells can be remarkably increased, the bone density is improved, and the purpose of promoting skeletal development is achieved. The preparation method is suitable for preparing formula milk powder capable of promoting skeletal development or health-care food beneficial to improving bone mineral density.

The invention relates to a synchronous differentiation method of single-sample-derived osteoclasts and osteoblasts and application of the synchronous differentiation method, and belongs to the technical field of biology. According to the method, bone marrow cells are extracted from long bones of mammals, adherent cell populations and suspension cell populations are separated after culture, the suspension cell populations are pre-cultured, the adherent cells are differentiated into osteoblasts, and the suspension cells are differentiated into osteoclasts after pre-culture, so that two functional cells are synchronously obtained from the same sample, and the dosage of experimental animals is remarkably reduced. The invention further provides a tartrate-resistant acid phosphatase dye liquor formula and a dyeing method on the basis, the dyeing time is shortened to be within 10 minutes, a high-risk concentrated hydrochloric acid reagent is not needed, heating at 37 DEG C is not needed, operation is easy and convenient, cost is low, and safety is high. According to the scheme, the problems of different sample sources, tedious dyeing process, long period, high cost and the like in the traditional technology are effectively solved, and an efficient and reliable experimental tool is provided for basic researches of bone development, osteoporosis and the like.

The application provides a casein phosphopeptide with the functions of promoting the absorption of calcium, iron, zinc, manganese and magnesium and improving bone health and a preparation method, and belongs to the technical field of casein phosphopeptide and comprises the following steps: S1, taking casein and adding pepsin for first enzymolysis; S2, taking the first enzymolysis solution, adjusting pH and temperature, and adding a compound enzyme for second enzymolysis; S3, after the second enzymolysis solution is inactivated, the casein phosphopeptide is obtained through treatment. The casein phosphopeptide prepared by the application has the following advantages: 1. can effectively complex mineral elements and reduce ion channel competition inhibition; 2. promotes the absorption of calcium, increases the hardness of the skeleton, and promotes the growth and development of the skeleton; 3. promotes the absorption of magnesium, assists calcium deposition, reduces bone loss, prevents osteoporosis, 3. promotes the absorption of iron, prevents iron deficiency anemia, and improves uncomfortable symptoms such as dizziness and fatigue; 4. promotes the absorption of zinc, enhances the activity of immune cells, improves resistance, and improves appetite. 5. promotes the absorption of manganese, activates the development of the skeleton, accelerates energy metabolism, and has antioxidant effect.

The invention belongs to the technical field of biosynthetic lipid preparation, and relates to a breast milk type structure lipid composition for promoting growth and development of infants and enhancing immunity and application. The preparation method of the breast milk type structure lipid composition comprises the following steps: reacting a mixed oil material with lipase to prepare a first structure lipid; performing steam deodorization inactivation enzyme activity on the first structure lipid to prepare a breast milk type structure lipid composition; the oil materials comprise the following components in parts by weight: 10-40 parts of palm oil, 5-32 parts of coconut oil, 15-30 parts of perilla seed oil or linseed oil, 10-25 parts of medium-chain fatty acid and 5-25 parts of algae oil DHA; the palm oil is 24 DEG C palm oil. The structural lipid composition is close to breast milk structural lipid, and has the following effects: the skeletal development promoting effect; growth and development are promoted; the effect of regulating intestinal flora is achieved; the immunity effect is enhanced; the brain development is promoted; the memory is improved; the intelligence development is promoted.

The application provides a child formula milk for promoting bone development and a preparation method thereof, and relates to the technical field of dairy products.The child formula milk for promoting bone development comprises the following raw materials in mass parts: raw cow milk 970-999 parts, a composite vitamin 0.05-1 part, a mineral 0.1-1.5 parts, colostrum basic protein 0.1-1 part and 2'-fucosyllactose 0.1-2 parts; the composite vitamin contains vitamin K, and the mass ratio of 2'-fucosyllactose to the composite vitamin is 0.5:1-20:1; the mass ratio of colostrum basic protein:2'-fucosyllactose: vitamin K: mineral is 1:(1-10):(0.1-0.5):(0.5-10). The child formula milk for promoting bone development can effectively promote bone development and improve product stability through specific content matching of each raw material component.

The present invention provides a combination of vitamin mixtures and synbiotics for use in enhancing bone growth and / or bone strength, for example, in children suffering from and / or developmental delay.

The invention belongs to the technical field of microorganisms and nutriology, and discloses bifidobacterium longum subsp.infantis CICC 6069 for promoting calcium absorption and application of a composition of the bifidobacterium longum subsp.infantis CICC 6069 and vitamin D in improvement of bone health. Cytology experiments and animal models verify that the strain can significantly promote absorption of intestinal epithelial cells to calcium ions and improve the serum calcium level and the calcium apparent absorption rate of calcium-deficient model animals; when the strain is combined with vitamin D, skeletal development (such as increasing bone length and improving bone mineral density) can be further remarkably promoted, and the synergistic effect is remarkably superior to that of single use of the strain. The invention provides an application of bifidobacterium longum infant subCICC 6069 in preparation of related products for promoting calcium absorption, and also provides a composition for promoting calcium absorption and / or improving bone health, and the composition comprises the strain and vitamin D. The invention further provides a preparation method of the bifidobacterium longum infant subCICC 6069 and a preparation method of the bifidobacterium longum infant subCICC 6069. The strain and the composition are suitable for preparing food, health food or medicine for promoting calcium absorption and improving bone health.

The invention relates to an application of an STAT3 agonist ColivelinTFA in the treatment of HIES (High Immunoglobulin E Syndrome) and osteoporosis. An osteoblast specific Stat3 knockout mouse is constructed through a Cre-loxp system, it is found that the mouse shows HIES-related bone deformity such as maxillofacial bone development deformity, spontaneous fracture and osteoporosis, and the mechanism that STAT3 inactivation causes HIES-related bone development deformity and osteoporosis by regulating osteogenic activity is proved. On the basis, it is proved that the STAT3 agonist ColivelinTFA can be used for treating osteoporosis caused by insufficient single dosage of STAT3 and stress loss. Compared with a diphosphate drug, the ColivelinTFA increases the bone mass by promoting bone metabolism instead of inhibiting bone metabolism, which may avoid a series of complications such as jaw bone necrosis caused by diphosphate to a certain extent.