41 results about "Hypoplasia" patented technology

Provided are methods and compositions for detecting and treating normal, hypoplastic, ectopic or remnant tissue, organ or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus and by a route providing access to above-mentioned tissue or organ, with an composition comprising antibody/fragment which specifically binds to targeted organ, tissue or cell. The antibody/fragment may be administered alone, or labeled or conjugated with an imaging, therapeutic, cytoprotective or activating agent.

An automatic Maxillary Expander, which is a bone-borne distractor for expanding the maxillary bone in adult and adolescents having transversal maxillary hypoplasia. It fixes itself to the palatal vault in a way without any need for screwing, by the asymmetrical triangular prism-shaped spikes on the anterior, posterior columns. Both being hygienic and not wasting a bulky space in the mouth, it provides a high patient comfort. The maxillary expanding process does not interrupt orthodontic treatment of patients and minimizes damage to the texture of the mouth. An automatic Maxillary Expander Transferring Apparatus enables the practitioner to place the Automatic Maxillary Expander into the palatal surface with ease and precision into the palate under local anesthesia quickly, without any surgical operation. In addition, this apparatus is composed of a very simple mechanism. It has rounded ends in order not to hurt the practitioner or patient.

The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

The invention discloses a chemiluminescence quantitative detection kit for estradiol. The kit comprises an estradiol detection reaction plate, an enzyme conjugate, a luminescent substrate, a calibrator, a quality control material and washing concentrate, wherein the reaction plate is coated with an estradiol antibody. The kit can specifically and quantitatively detect the content of the estradiol in patient serum, and is used for the auxiliary diagnosis of diseases such as ovarian hypoplasia, primary ovarian failure, pituitary amenorrhea or infertility, Cushing's syndrome, Addison's disease, malignant tumors, focal lesion of brain and hypophysis, and the like. Compared with the conventional enzyme linked immunosorbent assay (ELISA) technology, the chemiluminescence immunoassay keeps high specificity of the ELISA technology, stability and reliability of a detection result, and convenience of operation, and can improve detection sensitivity simultaneously.

A Chinese herba preparation for recuperating and curing ovarian hypoplasia of young girls or adult women is hot drink particles or a tea bag or a granular preparation consisting of kudzu roots, hawthorn, soya beans, red beans, black beans, fructus ligustri lucidi, eclipta alba, honeysuckle, Chinese rose, raw liquorice, dried tangerine or orange peels, fructus amomi, folium ginseng, dipsacus roots, eucommia bark, mistletoe, Japanese raspberry roots, winged euonymus twig, radix trichosanthis, pearl powder, yam flour, medicine beans and a packaging material. The Chinese herba preparation is used for preventing, recuperating and curing diseases including ovarian dysplasia or retardation of the young girls, ovarian hypofunction or hyperfunction, too little or too much estrogen secretion and ovarian and uterus dysgenesis of young married women, premature ovarian failure of older women, and barrenness of fertile women due to hypoplasia of ovum of ovarian, is used for moistening skin, retaining youthful looks and eliminating macula, and has the advantages that total effective rate of clinical recuperating and curing reaches 100% and the like.

The present invention concerns the preparation of substantially purified agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof.

The invention features soluble FGF decoy polypeptides and fusion polypeptides comprising an FGF decoy polypeptide linked to a heterologous polypeptide, such as an aggrecan binding protein. Both soluble FGF decoy polypeptides and fusion polypeptides can be used to prevent or treat skeletal disorders, such as achondroplasia.

The invention discloses an application of CTRP3 protein (C1qTNF related protein 3), and belongs to the fields of biotechnology and medicines. The CTRP3 protein provided by the invention can enhance the sensitivity of follicle to follicle stimulating hormone; and by identifying the expression of the CTRP3 protein in human and mouse ovaries, it indicates that the CTRP3 protein is autologous protein of the ovaries; therefore, the the CTRP3 protein can be safely developed and utilized as a drug. The effect of the CTRP3, as a follicle stimulating hormone sensitizer, on promoting follicle development is verified from three different levels, namely isolated ovarian tissue culture, isolated preantral follicle culture and living mesovarium injection, indicating that the CTRP3 protein, as the follicle stimulating hormone sensitizer, is effective on promoting preantral follicle and antral follicle development. The invention provides the effect and the mechanism of the CTRP3 participating in follicle development regulation and indicates that the CTRP3 protein, as the follicle stimulating hormone sensitizer, is applicable to the treatment of female ovarian hypoplasia diseases, so that the effect of the follicle stimulating hormone on the development of the follicle is enhanced.

The present invention relates to a device for treating male genital hypoplasia, growing its tissue and correcting existing curvature. The device of the present invention is unique in that it employs an external genital fixation system (1; 13) to which a diameter device (5) and a gland protection system (15) are connected. The external genital fixation system (1) and the upper element (13) create a traction force on the male external genitalia. The diameter device (5) creates a tissue expansion on the male genitalia. The gland protection system (15) avoids possible wounds, which makes it possible to use it for a long time without discomfort. Users of the device can wear it for months, several hours a day. Thus, for the treatment of male genital hypoplasia, timely tissue expansion and the opportunity to prolong the expansion are fundamental.

The invention relates to a pig SOX10 mutant gene causing inner ear hypoplasia and an application of the pig SOX10 mutant gene. The pig SOX10 mutant gene is characterized in that the 321st basic groupcytosine C of an SOX10 gene coding region is subjected to replication (SOX10 c.321 dupC), the mutation can cause infertility of the inner ear and is autosomal dominant inheritance, and can be used forpathogenesis, prevention, diagnosis and treatment research of infertility of the inner ear of a human body. The pig SOX10 mutant gene can be used for preparation of a disease animal model with incomplete development of the inner ear. The model can be used for research on pathogenesis, prevention, diagnosis and treatment on human inner ear hypoplasia, and is of great significance to research on inner ear hypoplasia.

The invention discloses application of a Bmal1 gene in preparation of a product for detecting and treating cartilage hypoplasia diseases, and belongs to the technical field of biological medicines. The nucleotide sequence of the Bmal1 gene in the invention is as shown in SEQ ID NO. 1, and the amino acid sequence of the Bmal1 gene is as shown in SEQ ID NO. 2. According to the invention, a molecular mechanism of the Bmal1 gene for regulating and controlling the biological process of cartilage growth and development is clarified, and a foundation is laid for research and development of drugs taking the P4ha1 gene as a target based on the biological clock gene Bmal1.

A method and system for treating maxillary transverse discrepancies in young orthodontic patients and in skeletally mature patients. The maxillary protraction device comprises a Hyrax provided with an adjustable screw and four bands connected to the Hyrax through connecting wires.

Placement of Hyrax on first maxillary molars and second maxillary premolars would create enough space for effective treatment of maxillary hypoplasia.

The invention discloses a traditional Chinese medicine composition for treating infertility and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: codonopsis pilosula, semen cuscutae, rhizoma atractylodis macrocephalae stir-fried with bran, poria cocos, Chinese yam, mistletoe, curcuma aromatic, radix dipsaci, parched white peony root, salted eucommia ulmoides, liquorice, radix rehmanniae praeparata, herba epimedii and prepared lumbricus in combination. The traditional Chinese medicine composition has accurate curative effects on threatened abortion of female patients, metrorrhagia and metrostaxis, morbid leukorrhoea, qi deficiency and blood stasis, adverse main and collateral channels, deficiency of vital energy and blood, unsmooth fallopian tubes, meridian disharmony, amenorrhea, dysmenorrhea, abnormal leukorrhea, endometriosis, hypoplasia of uterus, habitual abortion, pregnancy blood leakage, threatened abortion, threatened abortion, metrorrhagia and metrostaxis, irregular menstruation, metrorrhagia embolism in blood and the like.

The invention provides a method for verifying the effect of SAG in preventing environmental anomaly related bone dysplasia. The method comprises the following steps of changing the illumination condition in the environment, and inducing the establishment of a bone dysplasia model of an environmental rhythm disorder mouse; analyzing the bone mass and bone morphology of mandible and femur tissues of the rhythm disorder mouse, the multiplication capacity and collagen secretion capacity of corresponding cartilage cells and Hedgehog pathway related gene expression; and finally analyzing the treatment effect of the mandible and femur tissues of the mouse subjected to SAG treatment. According to the method for verifying the effect of the SAG in preventing the environmental anomaly related bone dysplasia provided by the invention, the influence of an illumination factor and time difference in the natural environment on bone growth and development can be simulated by constructing the illumination factor induced mouse bone dysplasia model, and by comparing the development conditions of the mandible and femur tissues before and after injection of the SAG, the effect of the SAG in preventing mandibular deficiency, short and deformed femur and the like can be effectively verified.

The invention relates to the combined use of selective serotonin reuptake inhibitors (SSRIs) and hematopoietic growth factors as a drug and particularly for treating cytopenia related to hematopoietic diseases or chemotherapy, and also to a pharmaceutical kit comprising both SSRIs and hematopoietic growth factors. This combination is more particularly used for treating patients presenting cytopenia, and patients in need of chemotherapy and more particularly to reduce length of chemotherapy-induced aplasia.

The invention discloses a medicament for treating hypoplasia of uterus and a preparation method of the medicament and belongs to the field of traditional Chinese medicines. The medicament is prepared from the following medicinal raw materials: humifuse euphorbia herbs, herbs of decumbent bugle, odontoglossum crispum, broad-leaved epiphyllum, wideleaf osbeckia roots, lesser galangal rhizome, aubergine root, cladonia alpestris, thlaspi arvense, Chinese abelia, climbing fig, chicory herbs, roots of luffa, Japanese flowering fern rhizome, Chinese aspen and salvia miltiorrhiza. The medicament is suitable in compatibility of the selected medicinal materials, accords with the theories of traditional Chinese medicine and modern pharmaceutics, has the efficacies of expelling cold, warming uterus, regulating conception channels, promoting blood circulation and removing obstruction in channels, is remarkable in curative effect in the hypoplasia of uterus caused by various reasons, is simple in preparation method and miraculous in effect, is safe, does not have side effects, is capable of curing the hypoplasia of uterus without relapse and enabling a patient to normally work and live in the period of taking the medicament and is worthy of being clinically and widely popularized and applied.