24 results about "Hypoplasia" patented technology

The utility model provides a bone anchorage type maxillary distraction osteogenesis device which comprises a spiral expansion device, and a rear base plate of the spiral expansion device is fixed to the rear half section of the maxillary bone through a left anchorage nail and a right anchorage nail. The front base plate and the rear base plate are respectively connected with at least two belt rings through belt ring connecting rods, the left front belt ring and the right front belt ring connected with the front base plate are at least sleeved on the first front molars on the corresponding sides, and the left rear belt ring and the right rear belt ring connected with the rear base plate are sleeved on the first molars and / or the second molars on the corresponding sides; the two front band rings are connected through a labial arch, and a lip baffle is fixed in the middle of the labial arch; a traction hook matched with a front tractor is fixedly connected to the outer ring face of the rear belt ring. According to the utility model, the osteotomy gap between the first premolar and the second premolar can be stably and effectively stretched, so that the aim of correcting skeletal hypoplasia or repairing bone defects is fulfilled.

The present invention relates to FGFR3 inhibitor compounds of novel structure or pharmaceutically acceptable salts, isotope variants, tautomers, stereoisomers or prodrugs thereof, and their use as medicine. The compounds are useful in the treatment of cancers such as urothelial carcinoma, systemic sclerosis, fibrosis, pulmonary fibrosis, cartilage insufficiency, lethal insufficiency, severe cartilage insufficiency accompanied by developmental retardation and atrachis ossicular, or muenke syndrome. # imgabs0 #

The present invention relates to methods for the treatment of a spinal deformity, such as thoracolumbar deformity in a subject in need of said treatment, said method comprising the step of administering a therapeutically effective amount of an inhibitor of FGFR3 signaling, or an NPR-B agonist and / or an NPR-C agonist to said subject.

The present invention relates to a method of treating spinal malformation, such as thoracolumbar malformation, in a subject in need of such treatment, comprising the step of administering to the subject a therapeutically effective amount of an FGFR3 signaling inhibitor or an NPR-B agonist and / or an NPR-C agonist.

This invention provides compounds of the following formula for treating systemic sclerosis, fibrosis (e.g., pulmonary fibrosis), achondroplasia, lethal dysplasia (e.g., type I), severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), Muenke syndrome, or cancer:

The invention provides a blank feeding device, and relates to the technical field of bottle blowing machine blank feeding. The blank feeding device is used for putting bottle blanks into an inlet of the blank discharging slide way and comprises a conveying mechanism and a blank feeding mechanism, the conveying mechanism comprises a conveying belt and a storage assembly, the conveying belt is arranged on one side of the inlet end of the blank discharging slide way, the storage assembly is movably arranged on the conveying belt, and the storage assembly comprises a plurality of positioning columns allowing the bottle blanks to be inserted. The blank feeding mechanism comprises a base, a blank feeding assembly and a grabbing assembly, the base is arranged between the inlet end of the blank discharging sliding way and the conveying belt, the blank feeding assembly is movably arranged on the base, and the grabbing assembly is arranged on the blank feeding assembly in a transmission mode. The blank feeding assembly can drive the grabbing assembly to put the grabbed bottle blanks into an inlet of the blank discharging sliding way. According to the blank feeding device, the labor intensity and the labor cost during production of large-size bottle bodies can be reduced, and the blank feeding efficiency is improved.

CASK-related disorders are caused by mutations in an important regulatory gene in the brain, calcium / calmodulin-dependent serine protein kinase (CASK) and can result in microcephaly with pontine and cerebellar hypoplasia (MICPCH), in addition to intellectual disability, and seizure activity. CASK-related Intellectual Disabilities (CASK-ID) predominantly affect the female population and are classified as X-linked neurodevelopmental disorders. CASK-ID is typically the result of a de novo loss of function mutation. As females have two Xchromosomes, disease causing mutations present with a 50 / 50 expression of mutant and wildtype, due to the mosaicism caused by random X-chromosome inactivation (XCI). This mosaicism presents an interesting therapeutic option of reactivating the intact allele in affected neurons. Disclosed herein are gene editing systems that can enhance in vivo CASK expression.

The present invention relates to FGFR3 inhibitor compounds, and specifically provides compounds of the following formula: for use in the treatment of systemic sclerosis, fibrosis (e.g., pulmonary fibrosis), cartilage insufficiency, lethal insufficiency (e.g., Type I), severe cartilage insufficiency (SADDAN) accompanied by developmental retardation and rosmarthosis, muenke syndrome, or cancer.

The present invention relates to an FGFR3 selective inhibitor compound or a pharmaceutically acceptable salt thereof. The compound can be used for treating cancer such as urothelial cancer, systemic sclerosis, fibrosis, pulmonary fibrosis, achondroplasia, thanatophoric dysplasia, severe achondroplasia with developmental delay and acanthosis nigricans, or Muenke syndrome.

A system and method configured to better identify patient-specific anatomical landmarks, measure anatomical parameters and features, and predict the patient's need for surgery within a predetermined time period. In some embodiments, the system and method is configured to predict the likelihood or risk that a patient will require total hip arthroplasty. In some embodiments, the present invention includes machine learning technology Some embodiments of the present invention include a first ML machine configured to received medical images as inputs and identify anatomical landmarks as outputs; a measurement module to measure joint space width, hip dysplasia angles, and / or leg length differential; and a second ML machine configured to receive the anatomical measurements and patient demographic data as inputs and produce a risk or likelihood that the patient will require surgery within a certain time frame.

The invention relates to a heterocyclic derivative inhibitor as well as a preparation method and application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound, and uses of the compound as an inhibitor in preparation of drugs for treatment and / or prevention of cancer and cartilage hypoplasia related diseases.

The present invention relates to structurally novel FGFR3 inhibitor compounds or pharmaceutically acceptable salts, isotopologues, tautomers, stereoisomers or prodrugs thereof, and their use as medicaments. The compounds can be used for the treatment of cancer such as urothelial cancer, systemic sclerosis, fibrosis, pulmonary fibrosis, achondroplasia, thanatophoric dysplasia, severe achondroplasia with developmental delays and acanthocytosis or Muenke syndrome.

Methods and materials for treating skeletal disorders are provided herein. For example, methods and materials for using a dual guanylate cyclase A and B activator (e.g., a polypeptide having the sequence set forth in SEQ ID NO:1) as a therapeutic agent for the treatment of skeletal disorders (e.g., achondroplasia) are provided herein.

The present inventors have uncovered the nature of heterotopic ossification HO progression as an excessive activation of TGF-β in recruitment of MSCs for osteogenesis in coupling with type H vessel formation. Systemic injection of TGF-β neutralizing antibody using the methods of the present invention, effectively attenuated HO progression in multiple different HO animal models. The present invention provides methods for prophylaxis and treatment of HO and also rare genetic diseases such as fibrodysplasia ossificans progressive (FOP) (also known as myositis ossificans progressive) and progressive osseous heteroplasia (POH). by inhibition of TGF-β.

The present disclosure provides compounds of the formula: for use in the treatment of systemic sclerosis, fibrosis (e.g. pulmonary fibrosis), achondroplasia, thanatophoric dysplasia (e.g. type I), severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), muenke syndrome or cancer.

This invention relates to novel FGFR3 inhibitor compounds or their pharmaceutically acceptable salts, isotopic variants, tautomers, stereoisomers, or prodrugs, and their use as medicine. These compounds can be used to treat cancers such as urothelial carcinoma, systemic sclerosis, fibrosis, pulmonary fibrosis, achondroplasia, lethal dysplasia, severe achondroplasia with developmental delay and acanthosis nigricans, or Muenke syndrome.

This invention relates to FGFR3 inhibitor compounds, and specifically, provides compounds of the following formula for the treatment of systemic sclerosis, fibrosis (e.g., pulmonary fibrosis), achondroplasia, lethal dysplasia (e.g., type I), severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), Muenke syndrome, or cancer:

This invention relates to the field of therapeutic drugs and systems for nervous system diseases, specifically to the application of Nrf2 in the preparation of therapeutic systems for treating nervous system diseases caused by tRNA synthetase deficiency. Through research on tRNA synthetase-deficient mutants, we discovered that tRNA synthetase deficiency causes a reduction in the size of the mesencephalon in zebrafish, resulting in symptoms of cerebellar hypoplasia and cerebral atrophy. In-depth research on the Perk signaling pathway involved in the above process revealed that the nfe2l2b gene and the Nrf2 protein are key factors regulating neural development, and their downstream target gene is p53. The inventors further applied the nfe2l2 gene to the preparation of therapeutic systems for treating nervous system diseases and to related drug screening, solving the technical problem of the lack of effective treatments for nervous system diseases caused by tRNA synthetase deficiency in the prior art, and possessing ideal value for widespread application.

Compositions and methods are disclosed herein for the treatment of neurocognitive disorders or central nervous system (CNS) disorders such as Alzheimer's disease (AD) and congenital heart diseases such as hypoplastic left heart syndrome (HLHS) with allogeneic mesenchymal stem cells (MSCs). The methods of treatment involve an administration of a composition of allogeneic mesenchymal stem cells to a subject in need thereof, wherein the effectiveness of the treatment methods can be determined through the measurement of specific biomarkers.

1. Name of this design product: Infraorbital nasal base integrated prosthesis. 2. Purpose of this design: To fill in the skeletal hypoplasia of the maxilla. 3. The key point of the design of this product lies in its shape. 4. The image or photograph that best illustrates the design's key points: 3D model 4.

The present invention provides compounds of general formula as fibroblast growth factor receptor 3 (FGFR3) inhibitors for use in the treatment of, for example, cancer, systemic sclerosis, fibrosis, pulmonary fibrosis, cartilage insufficiency, lethal dysplasia, severe cartilage insufficiency (SADDAN) accompanied by developmental retardation and rosmarthosis, and mohnker syndrome. Preferred compounds are, for example, pyrazolo [1, 5-a] pyridine and imidazo [1, 2-a] pyridine derivatives. # imgabs0 #

The present invention relates to the use of a Herba Bovis extract in improving the ovarian reserve capacity of mice. The present invention also discloses a preparation method of the Herba Bovis extract. The Herba Bovis extract of the present invention has the effect of improving sexual function, and specifically can solve the problem of decreased ovarian reserve capacity due to repeated superovulation; the Herba Bovis extract can effectively alleviate follicular hypoplasia, prevent abnormal changes in serum hormones caused by repeated superovulation, and reduce the activation of primordial follicles, thereby slowing down the process of ovarian aging. Not only that, the Herba Bovis extract also effectively slows down cell apoptosis in the ovary and the polarization of macrophages to pro-inflammatory M1 macrophages, plays a protective role in the survival and maturation of oocytes, thereby protecting the reserve capacity of the ovary; the present invention develops a new function of Herba Bovis, and provides a new idea for the development of drugs to improve sexual function.

This invention relates to FGFR3 inhibitor compounds, and specifically, provides compounds of the following formula for the treatment of systemic sclerosis, fibrosis (e.g., pulmonary fibrosis), achondroplasia, lethal dysplasia (e.g., type I), severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), Muenke syndrome, or cancer:

The invention discloses a CNP analogue and application thereof. According to the CNP analogue, a fatty acid side chain is coupled to a modified CNP peptide main chain, NPR-B agonist activity is reserved, the CNP analogue has a long half-life period, administration is more convenient, immunogenicity is smaller, irritation to an injection site is smaller, 50 nmol / kg of the CNP analogue is injected subcutaneously to a mouse, the effect of improving growth retardation caused by cartilage hypoplasia is better than that of drugs on the market, and the CNP analogue has a good application prospect. Moreover, the CNP analogue can also be used for treating various diseases which can be treated by CNP.