164 results about "Growth retardation" patented technology

Methods of treating language, behavioral and social disorders are described, including methods of treating language disorders associated with electrographic abnormalities in the primary or associative language cortex of persons with autism spectrum disorders, pervasive developmental delay or acquired epileptic aphasia. A language, behavioral and social disorder may be treated by detecting epileptiform activity or an electrographic seizure for a subject's brain and applying neurostimulation to a language cortical region of the subject's brain (e.g., a primary or associative language cortical region). Detection of epileptiform activity or an electrographic seizure and stimulation of language cortex may be performed by a sensing and / or stimulation electrode that is inserted into a subject's brain and connected to one or more neurostimulation devices for monitoring and / or stimulating the language cortex.

The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and / or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and / or long term regulation of energy balance; short-, medium- and / or long term regulation (stimulation and / or inhibition) of food intake; adipogenesis, adiposity and / or obesity; body weight gain and / or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and / or gastrectomy (ghrelin replacement therapy).

The invention relates to screening methods for determination of the risk of preterm delivery and / or pregnancy associated conditions. The methods involve detection of the level of one or more biomarkers in a biological sample from the patient. In particular, in embodiments of the invention there are provided methods for determining the risk of pre-eclampsia and other hypertensive disorders, and intrauterine growth retardation (IGUR).

The invention discloses porket creep feed and a production method thereof. The feed comprises the following components in percentage by weight: 30.0 expanded corns, 30.0 high-quality corns, 12.0 high-protein soybean meal, 4.5 whole milk powder, 4.0 fermentative soybean meal, 3.0 expanded soybeans, 3.0 Chilean white fish meal, 3.0 plasma protein powder, 3.0 acidifying agents, 2.0 sugar, 1.2 stone powder, 1.0 calcium dihydrogen phosphate, 1.0 grade-IV soyabean oil, 0.12 methionine, 0.4 lysine, 0.10 threonine, 0.18 salt, 1.0 porket additives and 0.5 medicament additives. The production method comprises the following steps: crushing the high-quality corns, the high-protein soybean meal and the Chilean white fish meal at one time, granulating at a high temperature and cooling; carrying out secondary crushing after the granulated and cooled high-quality corns, the high-protein soybean meal and the Chilean white fish meal are mixed with the expanded corns and the expanded soybeans; carrying out tertiary mixing with other components of the feed according to the weight percentage and granulating at a low temperature; and packaging and warehousing. The invention optimizes the quality of the porket creep feed, improves the stability and the palatability of the feed, strengthens the digestion and absorption and the availability of nutrition, promotes the health growth of porkets and effectively controls diarrhea, growth retardation, and the like.

The invention discloses a new traditional Chinese medicine composition for treating infantile cerebral palsy and a preparation method thereof. The traditional Chinese medicine composite is mainly prepared from the following raw materials of codonopsis pilosula, unprepared astragalus mongholicus, white paeony root, fructus alpiniae oxyphyllae, notopterygium root, radix angelicae, kudzu vine root, chrysanthemum, prepared rehmannia root, red-rooted salvia root, medicated leaven, Ligusticum wallichii, dalbergia wood, trichosanthes kirilowii Maxim, storax, rhizoma acori graminei, Chinese angelica, polygonum multiflorum, rhizoma sparganii, curcuma zedoary, cyperus rotundus, radix curcumae, cherokee rose fruit, plantain seed, leonurus, peach kernel, red flower, red-rooted salvia root, elecampane and the like. The traditional Chinese medicine composition can be made into any kind of common orally taken preparation by using conventional traditional Chinese medicine preparation methods. The traditional Chinese medicine composition can obviously improve muscle and bone weekness, bradygenesis, muscle flaccidity, head and neck enervation, mental incapacity, dull expression, sound delay, salivation, poor appetite, loose stool, slow response, logagnosia, dementia and other symptoms and achieve definite, obvious and quick treatment effect.

Embodiments of the invention relate generally to formulations comprising dimethyl sulfoxide (DMSO) to treat behavioral disorders, communication delays, and developmental delays. Several formulations disclosed herein are useful for treating broad autism phenotype disorders, including autism spectrum disorders (e.g., autism).

The invention relates to a medicament for tonifying liver, kidney and brain, and process for preparation, wherein the effective constituents comprise (by weight ratio) the following raw materials: mulberry 20-50g, fleece-flower root 20-50g, matrimony vine 8-16g, schisandra fruit 6-15g, ichih fruit 15-25g, wild or spiny jujuba seed 10-16g, arborviate seed 6-15g, mimosa-tree bark 10-16g, polygala root 10-16g, radix salvia miltiorrhiza 10-20g, Chinese angelica root 6-15g, kudzuvine root 8-16g, campanumaea pilosula 10-20g, Acorus calamus 8-16g, achyranthes and cyathula root 2-5g. The preparing process comprises steps of alcohol extracting and water extracting.

The invention discloses a mixed milk replacer and a preparation method thereof; the mixed milk replacer comprises the following raw materials in parts by weight: 16-20 parts of hulled corn, 15-20 parts of extruded corn, 6-10 parts of flour, 3-5 parts of white fish meal, 4-8 parts of debarked bean pulp, 2-5 parts of chyle fat powder, 2-3 parts of fermented bean pulp, 5-10 parts of whey powder, 3-6 parts of milk powder, 1-3 parts of white sugar, 2-3 parts of glucose, 0.4-0.5 part of monocalcium phosphate, 0.012-0.015 part of calcium formate, 0.01-0.03 part of high-temperature protease, 0.2-0.5 part of amino acid, 2-5 parts of thermostable amylase and culture thereof, 0.04-0.06 part of decavitamin and 0.2-0.6 part of compound microelements. The raw materials are mixed after being prepared to have the particle diameters of 2.0-3.0 mm and 10-15 mm; the mixed milk replacer pays attention to weak piglets and healthy piglets, reduces the feed waste, improves the food calling capacity and the food consumption, modifies the daily gain, and reduces the phenomena of negative gain and growth retardation caused by the weaning stress.

The invention discloses diarrhea-resistant forage for piglets and a preparation method thereof. The diarrhea-resistant forage is prepared from 300-340 weight parts of corn flour, 230-240 weight parts of wheat bran, 340-350 weight parts of rice bran, 10-12 weight parts of brown sugar, 20-23 weight parts of buckwheat, 12-14 weight parts of bone meal, 2-3 weight parts of yeast powder, 1-2 weight parts of table salt, 2-3 weight parts of tuber fleeceflower stem, 4-5 weight parts of pericarpium arecae, 1-2 weight parts of Lysimachia christinae Hance, 2-3 weight parts of herb of twinleaf zornia, 1-2 weight parts of eclipta alba, 1-2 weight parts of eucommia ulmoides leaf, 2-3 weight parts of isatis root, 2-3 weight parts of fructus amomi, 2-3 weight parts of jade powder, 1-2 weight parts of limonium bicolor, 1-2 weight parts of ginseng and 5-10 weight parts of a phagostimulant. The diarrhea-resistant forage has improved quality and improved stability, improves nutrient digestion and absorption, improves a nutrient utilization rate, promotes piglet healthy growth, effectively controls diarrhea and growth retardation, and solves the problem that the piglets have poor appetite, eat forage slowly, suffers from diarrhea easily, have a high death rate and low production performances.

The invention discloses a nutrient feed capable of improving laying rate of poultry. The nutrient feed is composed of the following raw material components by weight: 28-32 parts of corn, 18-22 parts of rice, 8-12 parts of bran, 2-3 parts of fish meal, 13-18 parts of bean pulp, 1-3 parts of calcium hydrogen phosphate, 0.01-0.03 parts of nucleic acid, 0.01-0.011 parts of glutamic acid, 0.01-0.03 parts of choline chloride, 0.073-0.078 parts of vitamin E, 0.09-0.11 parts of sodium selenite, 3-5 parts of stone powder, 8-12 parts of grass meal, 0.5-1.0 parts of zeolite and 0.20-0.25 parts of sandstone. The feed is reasonable in formula and comprehensive in nutrients; by using the feed to feed egg-laying chicken and egg-laying ducks, the egg weight is increased, the laying rate is improved, the eggshell hardness is enhanced and the breakage rate is reduced; and at the same time, the ingestion decrease or no ingestion, growth retardation and other symptoms caused by various diseases can be prevented.

The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and / or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and / or long term regulation of energy balance; short-, medium- and / or long term regulation (stimulation and / or inhibition) of food intake; adipogenesis, adiposity and / or obesity; body weight gain and / or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and / or gastrectomy (ghrelin replacement therapy).

The invention discloses a zinc gluconate orally disintegrating tablet for prevention and treatment of developmental retardation, undernourishment, apocleisis, ulcerative stomatitis, and skin acne, and its preparation. The tablet is prepared by using zinc gluconate as raw material, using bulking agent, crumbling agent, flavoring agent, flow aid, and lubricating agent as adjuvant, using bonding agent or dressing material based on specific situation, or charging right amount of effervescent agent, then using specific preparing procedure and employing a tablet compressing machine for pelleting. The tablet can be taken under the condition of waterless, it has the advantages of fast effect, improved compliance for the patients, and increased curative effect of the medicament.

The invention provides a pharmaceutical composition of lysine and vitamin containing chiral isocompounds, the pharmaceutical composition is mainly used for preventing or treating growth retardation of mammals and human, malnutrition, inappetence, cerebral ischemia, brain trauma, anemia, hair growth, hair loss, fatty liver, hepatitis, atherosclerosis, hyperlipidaemia or oxiunt radical scavenger and the like, the composition can better adapt to patients with metabolic acidosis and hyperchloremia, and the pharmaceutical composition can adapt to new applicable people on clinic use or can have better pertinence or better clinical safety.

The present invention provides novel triazole derivatives with improved receptor activity and bioavailability properties as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and / or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular alcohol disorder, drug abuse, growth retardation, cachexia, short-, medium-, and / or long term regulation of energy balance, short-, medium-, and / or long term regulation (stimulation and / or inhibition) of food intake, intake of rewarding food, adipogenesis, adiposity and / or obesity, body weight gain and / or reduction, diabetes, diabetes type I, diabetes type II, tumor cell proliferation, inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and / or gastrectomy (ghrelin replacement therapy).

The invention aims to disclose a medicinal composition for treating infantile cerebral palsy and a preparation method thereof, belonging to the technical field of medicine. The medicament is a medicinal composition which takes pure natural Chinese medicinal herbs as raw materials, is processed with meticulous care and is prepared according to a certain process. The medicament is mainly used for treating infantile cerebral palsy or intelligence development retardation, and has exact treatment effect. The raw materials for the medicament disclosed by the invention are wide in sources, accessible and low in cost. The preparation method of the composition disclosed by the invention is simple.

The invention relates to a special compound fertilizer for corns. The ratio of nitrogen to phosphorus to potassium to zinc in the compound fertilizer of the invention is 8-14:5-10:5-8:0.15-0.3. The special compound fertilizer for the corns can effectively promote the growth of corn crops, has an active promoting effect on the physiological and biochemical processes of the corn crops, improves the corn yield, and can solve the problems of growth retardation, decrescent plant leaves, dwarf plant, corn seed loss and bald tip and the like of the corns caused by zinc deficiency.

Duchenne muscular dystrophy (DMD) is a progressive muscle disease that is caused by severe defects in the dystrophin gene and results in the patient's death by the third decade. The present invention utilizes the Double Mutant mice (DM) as an appropriate human model for DMD as these mice are deficient for both dystrophin and utrophin (mdx / +, utrn − / −), die at 3 months of age and suffer from severe muscle weakness, pronounced growth retardation, kyphosis, weight loss, slack posture, and immobility. Expression from a transgene of novel human retinal dystrophin Dp260 was shown to prevent premature death and reduce the severe muscular dystrophy phenotype to a mild clinical myopathy. Electromyography, histology, radiography, magnetic resonance imaging, and behavior studies concluded that DM transgenic mice grew normally, had normal spinal curvature and mobility, and had reduced muscle pathology. EMG and histologic data from transgenic DM mice showed decreased abnormalities to levels typical of mild myopathy, while the DM mice exhibited severe abnormalities commonly seen in human dystrophinopathies. The transgenic DM mice also had measurable movement levels comparable to those of untreated mdx mice and controls.

The present invention relates to the use of a steroid in the manufacture of a pharmaceutical composition for use in the therapeutic or prophylactic treatment of a hypertensive disorder of pregnancy (HDP) or fetal growth retardation, said treatment comprising administering to a female mammal a steroid selected from the group consisting of: substances represented by the following formula (formula I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors of such substances; and mixtures of one or more of the aforementioned substances and / or precursors.

The present invention discloses a medicine and a preparation method for preventing and treating kidney essence deficiency. The medicine provided by the present invention has the efficacy of nourishing yin and tonifying yang, nourishing the kidney and strengthening the essence. The present invention can prevent and cure various diseases caused by kidney essence deficiency, such as growth retardation in children, oligospermia and sterility in male, less menstruation and amenorrhea in female, sexual deficiency, adult presenility, alopecia and loose teeth, dim eyesight and ear ringing, amnesia, foot atrophic debility, sexual hypofunction and osteoporosis. The present invention includes the following raw materials: prepared rehmannia root, yam, asiatic cornelian cherry fruit, barbary wolfberry fruit, dodder seed, deerhorn glue, tortoise-shell glue, ginseng, Chinese angelica, scurfy pea, eucommia, pachyma cocos, cassia bark, dried citrus peel and amomum villosum. According to the properties of each Chinese medicine, all raw materials are made into condensed water-paste pills, condensed water-honeyed pills or capsules through procedures of air drying, freeze drying and grinding, decocting and extracting, decompressed drying and grinding and disinfecting, which pertains to the art of Chinese medicine. The present invention has the advantages of scientific production method, no change of effective ingredients and significant prevention and cure effect.

The invention relates to a feed additive for improving pregnant sow reproductive performance and a preparing method thereof. The additive comprises traditional Chinese medicine composite components and N-carbamylglutamic acid. The weight ratio of the traditional Chinese medicine composite components and the N-carbamylglutamic acid is (20-30) : 3. The traditional Chinese medicine composite components comprise the components of, by weight, 10-30 parts of cortex magnoliae officinalis, 10-25 parts of immature bitter orange, 2-10 parts of mirabilite, 6-24 parts of raw rhubarb, 8-20 parts of radix paeoniae alba, 10-20 parts of rhizoma sparganic, 5-15 parts of curcuma zedoary, 5-15 parts of scutellaria baicalensis, 10-50 parts of dandelions and 5-15 parts of raw betel nuts. Compared with the prior art, nuisanceless natural Chinese herbal medicine is used, chemical synthesis antibacterial agents and toxic and harmful substances are not added at all, the preparing method is simple, the medicine absorbing degree and the bioavailability are high, preparing cost is low, sow gastrointestinal tracts are effectively nursed, constipation is avoided, the problems of sow intrauterine growth retardation and pregnancy early trimester placenta development and function limiting can be effectively solved, and then pregnant sow reproductive performance is obviously improved.

The invention relates to the field of medicines and discloses a traditional Chinese medicine composite used for treating infantile hypoevolutism and hypophrenia and a preparation method thereof. The composite comprises the raw materials of Rehmannia Glutinosa, vine of multiflower knotweed, rhizoma acori graminei, eucommia bark, Panax notoginseng, Schisandra Chinensis and the like, has the effects of tonifying the kidney and blood, promoting intelligence and soothing the nerves, and is mainly used for treating infantile cerebral dysplasia and brain injury which are caused by ischemia and hypoxia, hypomnesis, learning disabilities and other infantile hypoevolutism and hypophrenia symptoms.

The invention discloses a sand-shaped granulated creep feed product and a preparation method thereof. The sand-shaped granulated creep feed product comprises the following components in percentage by mass: 8.0 to 12.0 percent of maltodextrin, 33.0 to 40.0 percent of puffed broken rice, 10.0 to 15.0 percent of soy protein concentrate, 2.0 to 4.0 percent of plasma protein powder, 2.0 to 2.5 percent of dried porcine soluble, 1.0 to 4.5 percent of spray dried fish soluble protein powder, 15.0 to 20.0 percent of whey powder with high protein, 3.0 to 5.0 percent of glucose powder, 2.0 to 4.0 percent of emulsified oil powder, and 4.0 percent of 4 percent compound premixed feed. The fully soluble energy and protein raw materials are adopted by the sand-shaped granulated creep feed product, so that the digestibility of the feed is extremely high, the feed intake of piglets is large, the weaning stress is avoided, and the weight loss and growth retardation of the piglets are avoided. The granulated feed product obtained through rotational flow granulation is high in liquidity, and cannot be adhered everywhere to pollute the feed in a trough, so that the diarrhea of the piglets which is caused by the pollution of the feed is avoided.

The invention belongs to the technical field of nutritional healthcare food and particularly relates to an ocean polypeptide food for special dietary use and capable of promoting intelligence development. The food for special dietary use comprises the following raw materials in parts by weight: 5.0-15.0 parts of ocean oligopeptide, 1.5-2.0 parts of ocean bioactive polysaccharides, 1.5-2.0 parts of seaweed meal, 1.5-2.5 parts of nutritional amino acid, 1.5-2.5 parts of oligosaccharide, 0.2-0.8 part of nutrient, 0.03-0.10 part of vitamin, 0.2-0.8 part of mineral substance, 5.0-10.0 parts of bifidobacterium, 5.0-10.0 parts of lactobacillus, 2.0-5.0 parts of semen juglandis powder, 2.0-5.0 parts of Chinese yam powder, 2.0-3.0 parts of American ginseng powder and 2.0-3.0 parts of lucid ganoderma powder. The raw materials adopted in the invention are high in safety; the long-term eating of the food is free from side effect; the food is capable of promoting the memory of children and old people and guaranteeing the brain vitality and has an excellent therapeutic function for mental retardation and cerebral injury of the children.

The invention relates to a feed additive for improving the growth performance of intrauterine growth retardation piglets, and an application thereof, and belongs to the field of feeds. The feed additive comprises, by weight, 15-30 parts of N-carbamoylglutamic acid, 15-30 parts of soybean lecithin, 5-15 parts of leucine, 5-15 parts of tributyrin, 5-15 parts of calcium beta-hydroxy-beta-methylbutyrate, 5-15 parts of a complex enzyme-microecological preparation, 5-15 parts of vitamin E, 2-8 parts of folic acid and 2-8 parts of choline, and the complex enzyme-microecological preparation includes a complex enzyme preparation and a microbial agent. The feed additive can promote the growth of animals, and especially can improve the growth performance of the intrauterine growth retardation piglets; and the feed additive can be applied to the feeds in order to regulate the body immunity level of the intrauterine growth retardation piglets improve the muscle growth, enhance the functions of internal organs and promote the healthy growth of the gastrointestinal tract.

Methods of treating language, behavioral and social disorders are described, including methods of treating language disorders associated with electrographic abnormalities in the primary or associative language cortex of persons with autism spectrum disorders, pervasive developmental delay or acquired epileptic aphasia. A language, behavioral and social disorder may be treated by detecting epileptiform activity or an electrographic seizure for a subject's brain and applying neurostimulation to a language cortical region of the subject's brain (e.g., a primary or associative language cortical region). Detection of epileptiform activity or an electrographic seizure and stimulation of language cortex may be performed by a sensing and / or stimulation electrode that is inserted into a subject's brain and connected to one or more neurostimulation devices for monitoring and / or stimulating the language cortex.

The present invention relates to a health-care product, in particular, it relates to a lead-discharging growth-promoting tablet for preventing child growth retardation due to nutritional deficiency and higher blood lead content resulten from contaction with envriomental lead and its preparation method. Said lead-discharging growth-promoting tablet is made up by using vitarmin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin B12, zinc lactate, calcium carbonate, selenate polysaccharide, ferrous gluronate, lysine, taurine and xylitol through a certain preparation process. Besides, said invention also provides the concrete steps of its preparation method.

The invention discloses a lysine hydrochloride and zinc gluconate oral solution and the preparation method thereof. The weight composition of the raw materials is that: each 1ml of the oral solution contains the lysine hydrochloride and zinc gluconate with the mixing ratio of 3.125 to 25: 0.825 to 7.0, wherein, the best mixing ratio is 6.25 to 12.5:1.75 to 3.5. The weight mixing ratio of other components is that, sodium cyclamate: sucrose: lysine hydrochloride: zinc gluconate: citric acid is equal to 1.0: 0.5 to 1.0: 6.25 to 12.5: 1.75 to 3.5: 0.5 to 1.0. The lysine hydrochloride and zinc gluconate oral solution which is prepared by the formula and the preparation method has instant effects, high efficacy, being convenient to take, stable performance and safe and reliable usage. The invention can be widely used in the treatment of loss of appetite, food preference, xenorexia and growth retardation of children caused by zinc deficiency and lack of lysine.

The invention provides a breeding device of sturgeons in argillaceous body and relates to a breeding device. The invention aims at solving the problems that the fertilized eggs and larvae with ruptured membranes of sturgeons can not live in argillaceous water body, the upfront investment in facilities is great in breeding sturgeons artificially, and growth retardation and even mass mortality caused by the change of the environment in the critical breeding period of the fish fry exist. The two sides of each first mono-layered filter screen are fixedly connected with two panel bodies respectively; the double-layered filter screen is fixedly connected with the bottom part of the two panel bodies; one side of each side air bag waterproof bag is connected with the bottom air bag waterproof bag through a plurality of extensible belts; the external side of each panel body is provided with a side air bag; the bottom air bag is fixed on the bottom part of the double-layered filter screen; an air pump is respectively communicated with the side air bag gas tube and the bottom air bag gas tube; the branched passage of each side air bag is communicated with a group of first branch pipes which are installed in the inner container of the side air bag; the gas tube of the bottom air bag is communicated with a group of second branch pipes which are installed in the inner container of the bottom air bag; and the inner container of the air bag is provided with a group of gas needles. The invention is used for breeding sturgeons.

The invention discloses a CgWRKY57 encoding gene of cymbidium goeringii, and application of the encoding gene. The nucleotide sequence of the CgWRKY57 gene is shown in SEQ ID NO. 1, the amino acid sequence of the expressed protein of the CgWRKY57 gene is shown in SEQ ID NO. 2. By cloning and identifying the CgWRKY57 gene of 'Song Mei' which is a cultivated variety of the cymbidium goeringii, analyzing the gene expression and verifying the functions of the gene, an arabidopsis thaliana plant with the overexpressed CgWRKY57 gene is found to have phenotypes such as growth retardation and plant dwarf; therefore, the gene has a broad application prospect in the production and breeding of the cymbidium goeringii and other plants.