27 results about "Growth retardation" patented technology

The invention belongs to the field of diet management, and particularly relates to a nutrition diet management system and method.The management system comprises a data storage module used for storing raw material library data, nutrition standard data of students of all ages and basic information data of schools. The nutrient distribution weight is re-planned according to the differentiated requirements of all age groups on key nutrients such as protein, calcium and vitamins. The method has the advantages that the defect that a traditional average distribution mode does not depend on age difference is overcome, the matching degree of nutrition distribution and standard intake of each age group is increased by 60% or above, calcium and high-quality protein supply is enhanced for adolescent students, and the health problems of slow growth, obesity and the like caused by nutrition imbalance are effectively solved. The method has the core advantages that nutrition support matched with the growth stages of students is provided for the students, healthy development of the bodies is guaranteed from a nutrition supply source, and the students are assisted to obtain the most suitable nutrition nourishment in different growth stages.

Cryptosporidium parvum is a highly prevalent zoonotic and anthroponotic protozoan parasite that causes a diarrheal syndrome in children and neonatal livestock, culminating in growth retardation and mortalities. Disclosed herein are inhibitors against the enzymatic activity of recombinant CpLDH protein that were identified. The inhibitors were tested for anti-Cryptosporidium effect using in vitro infection assays of HCT-8 cells monolayers. Compounds NSC158011 and NSC10447 were identified to inhibit the proliferation of intracellular C. parvum in vitro, with IC50 values of 14.88 and 72.65 μM, respectively. At doses tolerable in mice, both NSC158011 and NSC10447 significantly reduced the shedding of C. parvum oocysts in infected immunocompromised mice's feces and prevented intestinal villous atrophy as well as mucosal erosion due to C. parvum. These findings have unveiled anti-Cryptosporidium drug candidates that can be explored further for the development of therapeutic agents against C. parvum infections.

The invention relates to the technical field of microorganisms, in particular to giant spheroidin Escherichia and application of the giant spheroidin Escherichia in promoting intestinal development of piglets. The Megasphaera elsdenii provided by the invention is preserved in Guangdong Microbial Culture Collection Center on May 22, 2025, the preservation number is GDMCC No: 66369, and the Megasphaera elsdenii can be used for promoting the development of intestinal tracts and intestinal mucosa of piglets and retarding growth retardation caused by weaning stress. In addition, the in-vitro pure culture supernatant of the giant spheroidin can also improve the viability of the jejunum stem cells and promote the proliferation of the epithelial cells of the pig intestinal tract.

This application relates to the field of feed, specifically to the application of UDCA in the preparation of formulations that reduce the incidence of intrauterine growth retardation (IUGR) in pregnant sows. According to the technical solution of this application, by adding 0.05% ursodeoxycholic acid to the diet of sows during late gestation (85 days) to the farrowing stage, using a restricted feeding method, at a rate of 2 kg / head / day, twice daily, the incidence of IUGR in sows can be effectively reduced by up to 76.17%, while also increasing the average weaning weight of piglets at 28 days by 9.61%.

The invention belongs to the field of animal husbandry, and particularly relates to application of melatonin or melatonin salt to improvement of weaning body conditions of newborn intrauterine delayed-development piglets. The invention accidentally finds that the concentration of the melatonin in the peripheral blood, colostrum and normal milk of the female livestock can be improved by treating the female livestock with the melatonin or the salt thereof in the period from delivery to lactation, so that the weaning body condition of the newborn IUGR baby lactated by the female livestock can be improved at the same time, and the melatonin or the salt thereof has important significance on improving the weaning body condition of the newborn IUGR baby. The method is simple in implementation step, good in effect and high in generalizability.

The present application relates to the technical field of intelligent internet of things mechanical fertilization control, and particularly relates to a corn staged fertilization control method based on internet of things. First, the present application obtains various nutrient data, hyperspectral images and growth stages of corn plants; further, the present application fuses overall nutrient data and overall NDVI value in each corn region to obtain growth suitability; further, the present application obtains real-time growth influence coefficients of each plant pixel point according to time sequence fluctuation of growth suitability of the same corn region, in combination with differences between growth suitability of the corn region and adjacent corn regions, and area of the corn region; further, the present application analyzes fluctuation of the growth influence coefficients and spatial offset of the corn region, in combination with growth retardation of the corn plant, to obtain real-time growth interference accumulation coefficients; finally, the present application realizes precise control fertilization in a staged and regional manner according to all growth interference accumulation coefficients corresponding to each corn region in real time, in combination with low degree of each nutrient data.

The present invention provides a combination of a vitamin mixture and an oligosaccharide mixture for use in enhancing bone growth and / or bone strength, for example, in a young child suffering from and / or being suffering from a growth retardation and / or a growth retardation.

The invention provides a multi-source data fused early risk screening method and system for growth retardation of children, and belongs to the technical field of medical information. The method comprises the following steps: acquiring a first predicted growth sequence and a second predicted growth sequence of a target child; performing compensation correction on the second predicted growth sequence based on the intergenerational compensation sequence to obtain a second corrected predicted growth sequence; performing fusion processing on the first predicted growth sequence and the second corrected predicted growth sequence, and establishing a target predicted growth sequence; and monitoring and acquiring a tracking and actually measured height sequence of the target child, performing comparative analysis on the tracking and actually measured height sequence and the target predicted growth sequence, and when the tracking and actually measured height sequence does not meet the target predicted growth sequence, generating a growth retardation early warning. The technical problem that early-stage growth retardation risks cannot be effectively identified due to insufficient early-warning accuracy caused by child growth prediction in the prior art is solved, and the technical effects of improving the child growth retardation risk prediction accuracy and realizing early-stage accurate early-warning are achieved.

The invention relates to the technical field of traditional Chinese medicines, and discloses a medicinal and edible homologous compound preparation for children as well as a preparation method and application thereof. The compound preparation is prepared from codonopsis pilosula, Chinese yam, lotus seeds, gordon euryale seeds, coix seeds, hyacinth beans, poria cocos, endothelium corneum gigeriae galli, hawthorn, rice sprouts, lily and red date pulp, all the raw materials are selected from medicinal and edible substances, and the compound preparation is safe and free of side effects; the preparation can be prepared into powder or a cake, and the preparation method comprises the steps of raw material treatment, stir-frying, crushing and sieving, mixing and sterilizing, packaging, cake preparation, cake preparation, forming and cutting, and drying. The compound preparation disclosed by the invention is based on the theory of'earth up to generate gold 'in traditional Chinese medicine, has the effects of invigorating spleen and tonifying lung, appetizing and helping digestion, clearing damp and soothing nerves and improving immunity, and is suitable for being eaten by 3-12-year-old children with weakness of spleen and stomach, slow growth and low immunity for a long time.

The invention provides application of DNA tetrahedral framework nucleic acid in preparation of a medicine for preventing and / or treating fetal alcohol spectrum disorder, and belongs to the field of biological medicine. The DNA tetrahedral framework nucleic acid provided by the invention is formed by DNA single chains with sequences as shown in SEQ ID No.1-4 through base complementary pairing and self-assembly. The DNA tetrahedral framework nucleic acid can cross the placenta barrier, alleviate alcohol-induced neural crest cell apoptosis and oxidative stress injury, alleviate Et-OH-induced ROS level rise in vitro by regulating an Nrf2 / HO-1 pathway, and has a protection effect on fetal alcohol spectrum disorder craniofacial malformation and intrauterine growth retardation. The DNA tetrahedral framework nucleic acid provided by the invention has a good application prospect in preparation of drugs for preventing and / or treating fetal alcohol spectrum disorders.

The present invention relates to a specific Cul7 gene knockout mouse model and a method and application for establishing the same based on the Cre / LoxP system. Specifically, parental Cul7<supgt;fl / fl< / supgt; mice are crossed with Col2a1-CreERT2 mice to obtain offspring with the genotype Cul7<supgt;fl / +< / supgt>; Col2a1-CreERT2 mice. The obtained Cul7<supgt;fl / +< / supgt>; Col2a1-CreERT2 mice are then crossed with Cul7<supgt;fl / fl< / supgt> mice, and Cul7<supgt;fl / fl< / supgt>; Col2a1-CreERT2 mice are obtained through genotyping of the offspring mice. The Cul7<supgt;fl / fl< / supgt>; Col2a1-CreERT2 mice are intraperitoneally injected with tamoxifen after birth, and a Cul7 cKO mouse model is successfully constructed, which shows obvious growth retardation and short limbs, consistent with the clinical manifestations of patients with 3M syndrome. The successful establishment of the model in the present invention provides a reliable experimental model for further studying the Cul7 gene signaling pathway and the pathogenic mechanism of 3M syndrome in the future.

The invention belongs to the technical field of biology, and particularly relates to a gene mutant related to growth retardation and application thereof. The invention provides a TRIO gene mutant related to growth and development retardation, and compared with a wild type TRIO gene, the TRIO gene mutant has c.7043delA mutation; and the login number of the wild type TRIO gene is NM007118.4. The invention also discloses a method for preparing the TRIO gene. The invention provides a new mutant gene for the existing gene field, and further researches the application of the mutant gene. The relationship between the mutation and the growth retardation is determined, a new scheme is provided for diagnosis and treatment of the growth retardation, and particularly, a diagnosis and treatment means is provided for the growth retardation.

The invention discloses a noninvasive diagnosis model for infant food allergy. The noninvasive diagnosis model is used for early recognition of infant food allergy. The model is established through multi-factor Logistic regression based on clinical common symptoms and risk factors, and comprises six variables: eczema severity, stool character, hemafecia, respiratory system symptoms, growth retardation and allergic disease family history. Various variables are endowed with different weights according to objective statistical results to form a model scoring formula: score = 0.23 * eczema (mild) + 1.02 * eczema (moderate) + 1.35 * eczema (severe) + 0.47 * stool (loose stool) + 1.42 * stool (watery stool) + 1.60 * hemafecia + 0.78 * growth retardation + 1.19 * respiratory system symptoms + 1.36 * allergic disease family history. Through verification of a training set and an independent test set, the model has relatively high diagnosis efficiency (AUC is about 0.86-0.87), when the model score is greater than or equal to 3.19, the food allergy is judged, and the optimal diagnosis effect can be achieved. The model is non-invasive, simple and convenient in evaluation process, small in error and high in compliance, and can assist clinicians in diagnosing infant food allergy.

The present invention provides methods for identifying an infant or young child at risk of growth retardation, and compositions for preventing and / or treating growth retardation in an infant or young child.

The invention provides application of vitamin C in preparation of a medicine for treating 1-naphthol poisoning, and belongs to the technical field of biological medicine. Research finds that vitamin C can effectively relieve animal development retardation caused by 1-naphthol and can also effectively treat animal pericardial edema caused by 1-naphthol, so that vitamin C has the effect of treating 1-naphthol poisoning.

The invention provides a functional feed additive for relieving development retardation of piglets as well as a preparation method and application of the functional feed additive. The functional feed additive for relieving development retardation of piglets comprises the following components in parts by weight: 30-50 parts of a polysaccharide-mesoporous silica nanoparticle compound, 0.1-2 parts of tartary buckwheat oligopeptide and 0.1-1 part of hesperetin. The functional feed additive provided by the invention can regulate the redox balance of piglet bodies, enhance the immunity of the piglet bodies, improve the intestinal mucosa injury of the piglets and promote the intestinal development of the piglets, so that the development retardation of the piglets is relieved, and the healthy growth of the piglets with the development retardation is promoted.

The invention discloses hydrolyzed egg yolk powder with a function of improving bone growth retardation and application of the hydrolyzed egg yolk powder, and belongs to the technical field of biological medicines. The hydrolyzed egg yolk powder is obtained by directional enzymolysis of degreased egg yolk powder and contains pentapeptide SFADF with the effect of promoting bone growth, and in a growth retardation model, after intervention of the pentapeptide SFADF or the hydrolyzed egg yolk powder containing the pentapeptide SFADF, the body length is remarkably increased by 4.3%, and the bone density is remarkably improved by 27.8%. The food-borne bioactive peptide is high in biological safety, so that the pentapeptide SFADF or the hydrolyzed yolk powder containing the pentapeptide SFADF can be applied to preparation of medicines for improving bone growth retardation or health-care foods for increasing bone mineral density, and the food-borne bioactive peptide has a good market prospect and application potential.

The present application provides a kind of piglet feed additive and preparation method thereof, belong to feed additive technical field.The piglet feed additive includes: periplaneta americana drug residue enzymatic hydrolysate, xylo-oligosaccharide, lactoferrin, hawthorn extract, astragalus polysaccharide, corn starch and vitamin C;The preparation method includes: periplaneta americana drug residue enzymatic hydrolysate, hawthorn extract, astragalus polysaccharide, corn starch, vitamin C are added into mixing machine according to weight fraction, stirring speed is controlled, and powder mixture is obtained by mixing;The powder mixture is sieved, and the agglomerate that is not mixed uniformly is removed, to obtain the finished product of piglet feed additive.Piglet feed additive aims to overcome the defects of prior art, realizes drug residue resource utilization, and solves the problems such as diarrhea, growth retardation, low immunity and other problems caused by immature digestive system and weaning stress of weaned piglets.The preparation method is simple and controllable, the product is natural and residue-free, and provides an environmentally friendly, efficient and practical feed additive for the pig industry.

The invention discloses an ointment for conditioning intestinal tracts and promoting growth and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 18-20 parts of radix pseudostellariae, 18-20 parts of bran-fried Chinese yam, 30-35 parts of rhizoma atractylodis macrocephalae, 30-35 parts of radix paeoniae alba, 18-20 parts of wine-processed rhizoma polygonati, 18-20 parts of radix cyathulae, 18-20 parts of scalded bone fragments, 12-15 parts of fructus lycii, 20-25 parts of fried endothelium corneum gigeriae galli, 20-25 parts of scorched hawthorn fruit, 20-25 parts of fried malt, 30-35 parts of medicated leaven, 20-25 parts of poria cocos, 12-15 parts of ligusticum wallichii, 12-15 parts of pulp of dogwood fruit, 12-15 parts of moutan bark, 6-8 parts of fructus gardeniae and 30-35 parts of semen boitae. The ointment for conditioning intestinal tracts and promoting growth is mainly suitable for children and adolescents with symptoms of growth retardation, digestive dysfunction and yin deficiency and internal heat caused by weakness of spleen and stomach, deficiency of liver and kidney and dyspepsia and internal heat, and the core is to improve the constitution basis through the comprehensive effects of tonifying spleen and kidney, promoting digestion and clearing heat, thereby promoting growth.

The present invention provides a combination of a vitamin mixture and an oligosaccharide mixture for use in enhancing bone growth and / or bone strength, for example, in children suffering from and / or being suffering from a growth retardation and / or a growth retardation.

The present invention provides a combination of a vitamin mixture and a synbiotic for use in enhancing bone growth and / or bone strength, for example, in children suffering from and / or being suffering from a growth retardation and / or growth retardation.

The present invention relates to the use of at least one muramyl peptide, such as muramyl dipeptide or one of its analogs, in the treatment of skeletal growth retardation in humans or juvenile animals. Figure for abstract: None

The invention relates to the technical field of animal feed, in particular to a cattle and sheep weaning concentrate formula, which consists of the following components in percentage by weight: 50 to 85 percent of energy-protein base material, 10 to 40 percent of plant function formula, 2 to 8 percent of mineral supplement, 0.5 to 3 percent of microbial regulator and 0 to 0.5 percent of optional drug additive, the plant functional formula is prepared by compounding Chinese herbal medicines with the functions of tonifying spleen and promoting appetite, clearing away heat and toxic materials and tonifying according to the weight ratio of (3-5): (1-3): (2-4), and preferably, the ratio of red date powder to dandelion powder to astragalus membranaceus powder to liquorice powder to elm leaf powder is 2: 1.5: 2: 1: 1.5; traditional breeding experience and modern nutrition technology are integrated, the problems of reduced feed intake, dyspepsia, low immunity, growth retardation and the like of cattle and sheep in the weaning period are solved in a targeted manner through a multi-component synergistic effect, and the feed does not need to depend on antibiotics, is high in safety and low in cost and can be prepared into dry powder or granular feed for use.

The application discloses a traditional Chinese medicine composition for helping sleep and growth, which is mainly made of the following traditional Chinese medicine raw materials in a certain proportion: 10-30g of Huangqi, 5-15g of fried Baishu, 2-8g of Chenpi, 10-20g of Dangshen, 5-15g of Shengma, 2-8g of Chaihu, 2-8g of Dangui, 10-30g of Shengdi, 5-15g of Zhigancao, 10-20g of Huishan, 5-15g of Danpi, 5-15g of Zexie, 5-15g of Shanzhu, 1-5g of Rougui, 5-15g of Fuling, 2-8g of Roudoukou, 5-15g of Muxiang, 1-5g of Huanglian, 2-8g of Sharen, 5-15g of Shanzha, 5-15g of Shenqu, 5-15g of fried Maiya and 5-15g of fried Maiya. Correspondingly, the application further discloses a preparation method and application of the traditional Chinese medicine composition for helping sleep and growth. By adopting the application, the traditional Chinese medicine composition can simultaneously treat poor sleep quality, growth retardation, short stature, cold constitution and adenoid hypertrophy, and can treat multiple diseases by using one medicine.

The peptide of the present invention has activity for promoting the production of growth hormone (GH) and promoting the growth of the growth plate. Accordingly, the peptide of the present invention can be used for promoting growth and can be effectively used as an active ingredient for the treatment, prevention, or alleviation of growth delay disorders such as short stature.

Cryptosporidium parvum is a highly prevalent zoonotic and anthroponotic protozoan parasite that causes a diarrheal syndrome in children and neonatal livestock, culminating in growth retardation and mortalities. Disclosed herein are inhibitors against the enzymatic activity of recombinant CpLDH protein that were identified. The inhibitors were tested for anti-Cryptosporidium effect using in vitro infection assays of HCT-8 cells monolayers. Compounds NSC158011 and NSC10447 were identified to inhibit the proliferation of intracellular C. parvum in vitro, with IC50 values of 14.88 and 72.65 μM, respectively. At doses tolerable in mice, both NSC158011 and NSC10447 significantly reduced the shedding of C. parvum oocysts in infected immunocompromised mice's feces and prevented intestinal villous atrophy as well as mucosal erosion due to C. parvum. These findings have unveiled anti-Cryptosporidium drug candidates that can be explored further for the development of therapeutic agents against C. parvum infections.

The invention discloses a CNP analogue and application thereof. According to the CNP analogue, a fatty acid side chain is coupled to a modified CNP peptide main chain, NPR-B agonist activity is reserved, the CNP analogue has a long half-life period, administration is more convenient, immunogenicity is smaller, irritation to an injection site is smaller, 50 nmol / kg of the CNP analogue is injected subcutaneously to a mouse, the effect of improving growth retardation caused by cartilage hypoplasia is better than that of drugs on the market, and the CNP analogue has a good application prospect. Moreover, the CNP analogue can also be used for treating various diseases which can be treated by CNP.