597 results about "Bioactive peptide" patented technology

The invention discloses two brand-new bioactive peptides with antioxidant and alpha-glucosidase inhibitory activity in traditional Chinese medicine hippocampus. The sequences of the novel bioactive peptides provided by the invention are respectively YLPPNW and SVWLGGSLL. According to the method, purity and structure identification is carried out on the new bioactive peptide obtained through separation by adopting liquid phase, primary mass spectrum and secondary mass spectrum, and a material basis is provided for further quality control and drug effect research of the traditional Chinese medicine hippocampus.

The invention relates to the technical field of polypropylene plastics, in particular to a high-strength antibacterial polypropylene plastic and a preparation method thereof. The antibacterial polypropylene material comprises the following components in parts by weight: 60-80 parts of polypropylene resin, 5-15 parts of nano titanium dioxide and nano zinc oxide composite particles modified by a special organosilicon polymer, 3-8 parts of an antibacterial agent compounded by quaternary ammonium salt and bioactive peptide, 5-10 parts of a core-shell structure MBS toughening agent and 0.5-2 parts of a hindered phenol-thioether composite antioxidant. 1-3 parts of a calcium stearate processing aid; and 3-8 parts of dopamine modified chopped carbon fibers. The composite material is high in strength, tensile strength, bending strength and impact strength are remarkably improved, and larger external force can be borne; the antibacterial performance is excellent, and the antibacterial rate reaches 95%-99%; the preparation process is environment-friendly and efficient, and the product is good in stability and recoverable; product safety can be guaranteed, the service life is prolonged, and economic and social benefits are good.

The invention relates to the field of preparation and application of biological peptides, in particular to a swelling hippocampal peptide and application of the swelling hippocampal peptide in preparation of anti-fatigue products. Five active peptide sequences with high biological activity are obtained through research, animal behavioral experiments prove that the belly distention hippocampal peptide has a remarkable anti-fatigue effect and can prolong the swimming exhaustion time and enhance the muscle strength, the anti-fatigue effect of the belly distention hippocampal peptide is verified, and a new way is provided for development of anti-fatigue hippocampal products.

The invention discloses a method for preparing, enriching and separating various egg yolk bioactive peptides through enzymolysis of defatted egg yolk powder and application of the egg yolk bioactive peptides, and belongs to the technical field of egg product processing and bioactive peptides. Egg yolk protein hydrolysate is prepared by adopting a three-step enzymolysis process, adsorption and gradient elution are performed on the egg yolk protein hydrolysate by adopting a macroporous resin chromatographic column, four components including water-1, water-2, 20% ethanol and 80% ethanol are obtained, the water-1 component is common egg yolk peptide, the water-1 component is enriched with osteogenic active peptide, the water-2 component is enriched with ethanol, and the 80% ethanol is enriched with ethanol. The 20% ethanol component enriches antioxidant peptide, and the 80% ethanol component enriches ACE inhibitory peptide. The functional activity of each bioactive peptide component is very strong, and the bioactive peptide component can be used as a high-end functional ingredient. According to the method disclosed by the invention, comprehensive utilization of the degreased yolk powder is realized, enrichment and separation of three active peptides are realized by using one raw material through a step-by-step enzymolysis-directional separation technology, the yield of the active peptides is greatly improved, and the economic benefits of enterprises are improved.

The invention provides a snail bioactive peptide quality tracing system and method based on big data, and belongs to the technical field of snail bioactive peptides. Comprising a data acquisition module used for acquiring various data in the production process of the snail bioactive peptide, a big data processing module used for integrating and cleaning the data, and an intelligent quality analysis module used for analyzing the quality of the snail bioactive peptide. The intelligent quality analysis module is used for carrying out quality prediction and abnormal early warning on the snail bioactive peptide, and the block chain tracing module is used for carrying out quality tracing on the snail bioactive peptide. According to the method, data islands of cultivation, production and detection links can be broken, cross-link association analysis is realized, manual sampling inspection is upgraded to AI-driven real-time early warning and process optimization, data authenticity is guaranteed through a block chain technology, international compliance requirements are met, and consumer trust and brand price are improved by adopting three-dimensional visualization and scientific data.

The invention discloses ACE (Angiotensin Converting Enzyme) inhibitory octapeptide YI8 derived from bovine cheese protein hydrolysate and application, and relates to the technical field of bioactive peptides, and the technical scheme is characterized in that the ACE inhibitory octapeptide YI8 comprises an amino acid sequence of YKVPQLEI. The ACE inhibitory octapeptide YI8 derived from the cattle cheese protein hydrolysate is obtained by screening from the cattle cheese protein hydrolysate, and is an octapeptide YI8 with ACE inhibitory activity, the in-vitro ACE inhibition rate of the ACE inhibitory octapeptide YI8 derived from the cattle cheese protein hydrolysate is tested to be 70.86% under the condition of the concentration of 1mg / ml, and the ACE inhibitory octapeptide YI8 is suitable for functional food for assisting in lowering blood pressure.

The invention relates to the technical field of bioactive peptides, in particular to an antioxidant peptide based on mussel byssus, a preparation method, a preparation and application of the antioxidant peptide based on mussel byssus, the antioxidant peptide is designed and synthesized by referring to the structural characteristics of mussel byssus proteins mfp-3, mfp-5 and mfp-6, the antioxidant peptide comprises four sequences of MFP3-AP1, MFP5-AP2, MFP6-AP3 and MFP-Hybrid, tyrosine in the peptide is modified into DOPA through enzymatic modification, and the antioxidant peptide is prepared through enzymatic modification. The stability and activity of the antioxidant peptide are enhanced through disulfide bond formation, metal ion coordination, PEGylation and other modifications, and the antioxidant peptide has high DPPH free radical scavenging activity, ABTS free radical scavenging activity, hydroxyl free radical scavenging activity and iron ion reducing capacity, has a protective effect on the cellular level, can be prepared into a liquid preparation, a freeze-dried preparation or a micro-capsule preparation, and can be used for preparing the antioxidant peptide. The compound is expected to be applied to the fields of antioxidant health care products, cosmetics and medicines.

The invention discloses a yolk protein source tripeptide with a function of improving osteoporosis and application of the yolk protein source tripeptide, and belongs to the technical field of biological medicines. The tripeptide is a tripeptide APW of which the amino acid sequence is Ala-Pro-Trp. The peptide fragment can be obtained through artificial synthesis or directional enzymolysis of defatted yolk powder. Functional verification shows that the tripeptide APW and the egg yolk protein hydrolysate containing the peptide fragment have the function of improving the bone mineral density, and in a zebra fish osteoporosis model, when the egg yolk protein hydrolysate is 20 mu g / mL, the bone mineral density is improved by 58%; when the tripeptide APW is 0.5 mu g / mL, the bone mineral density is increased by 23.4%; in a rat osteoporosis model, the bone mineral density of thighbone is increased by 3.39% after 10 mg / kg. D of egg yolk protein enzymatic hydrolysate is eaten. Moreover, the food-borne bioactive peptide is high in biological safety, so that the tripeptide APW and a yolk protein enzymolysis product containing the peptide fragment can be applied to preparation of medicines for treating osteoporosis or health-care foods for improving bone mineral density, and the tripeptide APW has a good market prospect and application potential.

The invention relates to the technical field of bioactive peptides, in particular to a novel multifunctional collagen-like tripeptide and application thereof, an amino acid sequence contains multiple combinations, X can be selected from multiple components, 3-methoxy-4-hydroxyphenylalanine and the like are added, and the novel multifunctional collagen-like tripeptide can interact with specific proteins, activate related pathways and play multiple physiological functions and is applied to multiple fields. The collagen-like tripeptide has obvious advantages, innovates component expansion functions, improves the preparation method, improves the efficiency, reduces the cost, is matched with other components in the fields of beauty, health care and medicine, enhances the efficacy, realizes targeted delivery, and brings a new opportunity to related industries.

The invention discloses a tortoise shell bioactive peptide and a preparation method and application thereof.The tortoise shell bioactive peptide comprises one or more of EHTVVY, GPKKDQK, SPLSDVRGH, SENADKGALS and DPKMNGLK. The preparation method comprises the steps of preparation of tortoise shell protein hydrolysate, ultrafiltration separation, anion exchange resin separation, gel column separation, de novo sequencing analysis, molecular docking screening and solid-phase synthesis. The tortoise shell bioactive peptide can be applied to the fields of oxidation resistance and immunoregulation. The method disclosed by the invention is a separation, purification and identification technical method of the tortoise shell specific antioxidant polypeptide based on activity guidance, and has the advantages of clear components, clear activity, clear mechanism and the like; the obtained specific polypeptide has important significance for functional product development of polypeptide compounds with clear tortoise shell components.

The invention relates to the field of preparation and application of biological peptides, in particular to a swelling hippocampal peptide and application thereof in preparation of uric acid reducing and gout resisting products. The amino acid sequence is shown as SEQ ID NO.1-5. The uric acid reducing effect is verified by adopting an in-vitro XOD inhibition experiment and a cell experiment; furthermore, the uric acid reducing and gout resisting activity of the compound is verified through a hyperuricemia animal model, and a theoretical basis is provided for high-valued utilization of the belly-swelling hippocampus and development of uric acid reducing and gout resisting products.

The invention discloses a fish by-product active peptide, a preparation and application, and belongs to the technical field of biological active peptides. The amino acid sequences of the fish by-product active peptide are shown as SEQ ID NO: 1 to SEQ ID NO: 3. Both the single peptide fragment and the compound peptide fragment of the fish by-product active peptide can obviously inhibit NO secretion of a lipopolysaccharide (LPS)-induced macrophage (RAW264.7) inflammation model, so that the fish by-product active peptide has a relatively good application prospect in preparation of a product with an anti-inflammatory effect; and a foundation is laid for high-added-value utilization of salmon byproducts and promotion of research, development and application of functional active peptides.

The invention relates to the technical field of bioactive peptides, and particularly discloses a peptide oxidation resistance prediction method and system based on a pre-training model and descriptors, and the method comprises the following steps: obtaining an amino acid sequence of a to-be-predicted polypeptide and a physicochemical characteristic description index of each amino acid; enabling the coded amino acid sequence to pass through a BERT embedding layer to form high-dimensional vector representation, inputting the high-dimensional vector representation into a pre-trained deep neural network model to obtain features of a peptide sequence, and inputting the features of the peptide sequence into a pre-trained artificial neural network to obtain deep representation of the peptide sequence; according to the physicochemical characteristic description index of each amino acid, generating a characteristic vector of each amino acid, and constructing the characteristic of the polypeptide; and inputting the depth representation of the peptide sequence and the characteristics of the polypeptide into a predictor to obtain a prediction result of the oxidation resistance of the peptide. According to the method, the fine-tuned model characterization is combined with the traditional peptide sequence descriptor, so that the prediction accuracy of the antioxidant peptide and the stability of the model are successfully improved.

The invention discloses a method for preparing various bioactive peptides based on bean dreg fermentation, which comprises polypeptides with alpha-glucosidase inhibitory activity, angiotensin converting enzyme inhibitory activity and antioxidant activity, and belongs to the field of microbial biological fermentation. Bacillus amyloliquefaciens sourced from fermented soybeans is used for fermentation, and a mixed product with alpha-glucosidase inhibitory activity, angiotensin converting enzyme inhibitory activity and antioxidant activity is obtained. The invention also provides a method for purifying the polypeptide with alpha-glucosidase inhibitory activity, angiotensin converting enzyme inhibitory activity and antioxidant activity, which is characterized in that the mixed product is purified by combined column chromatography, the combined column chromatography comprises cation exchange resin LXP-01, macroporous adsorption resin HP20, weak base anion exchange resin D941, silica gel resin and Sephadex LH-20. The invention also discloses seven bioactive peptides with biological activity, the amino acid sequences are CKLLL, APGYSC, FPKYG, FPGPLV, FPRSH, FMAV and SVCC, and the bioactive peptides have good alpha-glucosidase inhibitory activity, angiotensin converting enzyme inhibitory activity and antioxidant activity, and can be used for producing functional foods, health care products, cosmetics and the like for assisting in reducing blood sugar, reducing blood pressure, resisting oxidation and the like.

The invention discloses a blood protein precise active peptide capable of tonifying qi and blood, improving microcirculation and promoting vasodilation and a preparation method and application thereof, and belongs to the technical field of blood protein peptide. The blood protein precision active peptide comprises at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII or FPHFD. The prepared blood protein precision active peptide has multiple biological activities: an antihypertensive effect is achieved by inhibiting ACE and vasoconstriction substances; vasodilation is promoted by activating a PI3K / AKT / eNOS signal channel; a zebra fish model proves that the traditional Chinese medicine composition has the effects of remarkably improving microcirculation and tonifying qi and blood. The preparation method is low in equipment requirement, simple in process, easy to operate and convenient for industrial large-scale production. The method enriches a bioactive peptide library, and is of great significance in promoting technical progress and industrial upgrading in the field of hemoglobulin peptides.

The invention discloses ACE (Angiotensin Converting Enzyme) inhibitory decapeptide IR10 derived from bovine cheese protein hydrolysate and application of the ACE inhibitory decapeptide IR10, and relates to the technical field of bioactive peptides, and the technical scheme of the ACE inhibitory decapeptide IR10 is characterized in that the amino acid sequence is IQKEDVPSER. The ACE inhibitory decapeptide IR10 derived from the cattle cheese protein hydrolysate is obtained by screening from the cattle cheese protein hydrolysate and is decapeptide IR10 with ACE inhibitory activity, the in-vitro ACE inhibition rate of the ACE inhibitory decapeptide IR10 derived from the cattle cheese protein hydrolysate is tested to be 62.07% under the condition of the concentration of 1mg / ml, and the ACE inhibitory decapeptide IR10 has the effect of being suitable for functional food for assisting blood pressure reduction.

The invention provides a spirulina-derived ACE (angiotensin converting enzyme) inhibitory peptide as well as a preparation method and application thereof, and belongs to the technical field of marine bioactive peptides. Spirulina phycobiliprotein is used for preparing the ACE inhibitory peptide of the spirulina source, five kinds of small molecule polypeptides including YATY, RYVTY, YVTY, KAYF and SPSWY are obtained through co-screening, the five kinds of polypeptides all have good ACE inhibitory activity, and the RYVTY activity is the highest. The spirulina-derived polypeptide prepared by the preparation method disclosed by the invention has high hydrolysis degree and high ACE inhibitory activity, can be applied to the fields of food, health care products, medicines and the like, and has a wide application prospect.

The invention provides collagen tripeptide liquid with moisturizing and anti-photoaging effects and a preparation method thereof, and relates to the technical field of bioactive peptides.The preparation method comprises the steps that pretreatment and first-time enzymolysis are conducted, specifically, pretreated fish skin and water are mixed, the pH value is adjusted, compound protease is added for enzymolysis, and first enzymatic hydrolysate is obtained; second-time enzymolysis: adjusting the pH value of the first enzymatic hydrolysate to 6.0-7.5, adding neutral protease for enzymolysis, and then adding aminopeptidase for enzymolysis for 20-40 minutes to obtain second enzymatic hydrolysate; and performing enzyme deactivation, decoloration, separation and purification to obtain collagen tripeptide liquid. Wherein the content of collagen tripeptide, the content of glycine-proline-hydroxyproline and the content of hydroxyproline are high, and good moisturizing and anti-photoaging effects are achieved.

The invention discloses a bioactive peptide with antioxidant and hypoglycemic effects, a preparation and application thereof, and belongs to the technical field of bioactive peptides. The bioactive peptide provided by the invention is as shown in at least one of SEQ ID NO: 1 to SEQ ID NO: 4. Degreased shiny-leaved yellowhorn meal is used as a raw material, after high-temperature heat treatment and ultrahigh-pressure pretreatment are performed, the bioactive peptide with antioxidant and hypoglycemic effects is separated through enzymolysis, ultrafiltration and a liquid chromatography separation technology in combination with a bioinformatics technology, and components and sequences of the bioactive peptide are preliminarily identified through a liquid chromatography-mass spectrometry technology. And carrying out chemical synthesis according to the identified peptide fragment sequence to obtain four bioactive peptides with antioxidant and hypoglycemic effects. Through detection, the peptide fragments and the compound peptide fragments thereof have good alpha-glucosidase and alpha-amylase inhibitory activity, and have good application prospects in preparation of products with antioxidant and hypoglycemic effects.

The invention relates to a bioactive polypeptide GIVVVPGSGF as well as a preparation method and application thereof. The bioactive polypeptide GIVVVPGSGF provided by the invention has bitter taste, the crystal of the bioactive polypeptide GIVVVPGSGF is powdery, and the bioactive polypeptide GIVVVPGSGF can be combined with a bitter taste receptor TAS2R14. The bioactive polypeptide can be used as a bitter additive and an additive for foods and beverages, and the beverages comprise alcoholic beverages and non-alcoholic beverages. The bioactive peptide GIVVVPGSGF provided by the invention is a small-molecular-weight peptide screened from yellow wine, sensory evaluation and electronic tongue results show that the extracted bitter peptide has good bitter taste and richness, on one hand, the bioactive peptide GIVVVPGSGF has high bitter taste strength, can properly improve the bitter taste of wine, and may increase the flavor quality under certain conditions; on the other hand, the bitter peptide GIVVVPGSGF in the yellow rice wine is properly removed, so that the evaluation experience of the yellow rice wine can be improved.

The invention provides a preparation method of collagen yeast peptide, and belongs to the technical field of collagen biology. The preparation method comprises the following steps: adding collagen into water, uniformly stirring, then adding a nutrition enhancer accounting for 8-12wt% of the mixed system, and adjusting the pH value to 5.8-6.2 to obtain a fermentation substrate; and inoculating lactobacillus rhamnosus and lactobacillus plantarum into the fermentation substrate, controlling the dissolved oxygen to be 20-30% in the first 24 hours, reducing the dissolved oxygen to be 5-10% in the later 48 hours, and filtering and drying the fermented product to obtain the collagen fermented peptide. Through synergistic fermentation of composite strains, the product is rich in 300-1500Da bioactive peptide, Pro-Hyp-Gly and gamma-aminobutyric acid and has the functions of inhibiting tyrosinase, resisting oxidation, whitening and regulating intestinal flora, the melanin reduction rate reaches 22% in clinical 8 weeks, and the shelf life is prolonged to 18 months.

The invention relates to a hemoglobin peptide capable of promoting iron absorption and a preparation method thereof, the mass content of polypeptide in the hemoglobin peptide is greater than 90%, and the hemoglobin peptide contains at least one of FERF and FDGL; the preparation method comprises the following steps: S1, adding trisodium citrate into fresh animal blood, centrifuging, adding a NaCl solution for washing, preparing the solution, and performing high-pressure homogenization wall breaking for 2-5 times to obtain a hemoglobin solution; s2, adding 10-200 U / mL of neutral protease, carrying out heat preservation treatment, then adding 5-50 U / mL of flavourzyme, carrying out enzymolysis, and carrying out enzyme deactivation to obtain an enzymatic hydrolysate; s3, filtering with an ultrafiltration membrane, and collecting permeate; s4, adjusting the pH value, adding into an anion exchange chromatographic column, eluting with a NaCl solution, and collecting the eluent; s5, desalting, concentrating and drying to obtain hemoglobin peptide; and S6, carrying out mass spectrometric detection, and screening bioactive peptides to obtain the oligopeptide with the activity of promoting iron absorption. The hemoglobin peptide obtained by the preparation method disclosed by the invention has relatively good iron chelation capability and iron absorption promoting capability, and the bioavailability of iron ions can be remarkably improved.

The invention discloses a corn active peptide with effects of dispelling effects of alcohol, reducing uric acid and resisting oxidation, a preparation and application of the corn active peptide, and belongs to the technical field of biological active peptides. The amino acid sequence of the corn active peptide is at least one of LMFP, FEGLFR, FLR and QLPSYR. The corn active peptide with the effects of dispelling the effects of alcohol, reducing uric acid and resisting oxidation is separated from corn germ meal through enzymolysis, ultrafiltration and other technologies, amino acid sequence determination is conducted on the separated peptide fragments, screening is conducted in combination with the bioinformatics technology, and finally four peptide fragments are obtained. According to the present invention, the corn active peptides are identified, chemical synthesis is performed according to the identified peptide fragment sequence, the effects of alcohol effect dispelling, uric acid reducing and oxidation resistance of the synthesized single peptide fragment and the compounded peptide fragment are determined, and the corn active peptides have good XOD inhibition rate, good DPPH clearance rate and good ADH activation rate, and have important application prospects in the development of the products with effects of alcohol effect dispelling, uric acid reducing and oxidation resistance.

The present invention belongs to the technical field of plant extracts, and more specifically, relates to the use of a carob extract in a drug for improving glucose metabolism / polycystic ovary syndrome in women. The present invention discloses a pharmaceutical composition for improving glucose metabolism and treating polycystic ovary syndrome in women, the pharmaceutical composition comprising: carob extract, baicalein, cedrol, a bioactive peptide, a biopolysaccharide, and excipients. The composition of the present invention has the effects of lowering blood sugar and blood lipids, improving insulin function, and also has antioxidant and immunity-enhancing effects. By combining the above substances, a synergistic effect is achieved, further enhancing the effect of improving / treating polycystic ovary syndrome in women associated with abnormal glucose metabolism.

The invention discloses a marine-derived bioactive peptide with a blood sugar reducing effect, a preparation and application, and belongs to the technical field of bioactive peptides. The amino acid sequence of the bioactive peptide is at least one of FYP, FPF and YAPFPK. Three bioactive peptides with the blood sugar reducing effect are separated and purified from oysters through enzymolysis, ultrafiltration, gel chromatography, liquid chromatography-mass spectrometry and bioinformatics technologies. According to the present invention, chemical synthesis is performed according to the identified peptide fragment sequence, the hypoglycemic activity of the synthesized single peptide fragment and the compounded peptide fragment is detected, and the bioactive peptides have good alpha-glucosidase inhibition activity, such that the bioactive peptides have good application prospects in the preparation of the products with the hypoglycemic effect, and can be widely used in the preparation of the products with the hypoglycemic effect. And a foundation is laid for high value-added utilization of oysters and promotion of research, development and application of functional active peptides.

The invention discloses a fucoidin-bioactive peptide coated intravascular stent and a preparation method thereof, and belongs to the technical field of medical treatment. The surface of the fucoidin-bioactive peptide coating intravascular stent is coated with a composite coating, and the composite coating is composed of fucoidin and bioactive peptide. The invention discloses a fucoidin-bioactive peptide coated intravascular stent and a preparation method thereof, and the fucoidin-bioactive peptide coated intravascular stent not only solves the problems of poor blood compatibility and slow endothelialization, but also has multiple functions of anticoagulation, anti-proliferation and repair promotion. The intravascular stent coating technology is comprehensively upgraded, and a safer, more effective and more lasting solution is provided for treatment of cardiovascular diseases.

The invention discloses a yak milk-derived antioxidant peptide and a screening method and application thereof, and belongs to the technical field of bioactive peptides, the yak milk-derived antioxidant peptide is DGGY, the amino acid sequence of the yak milk-derived antioxidant peptide is shown as SEQ ID NO.1, the molecular formula of the yak milk-derived antioxidant peptide is C17H22N4O8, the chemical structural formula of the yak milk-derived antioxidant peptide is # imgabs0, and the invention further discloses the screening method and application of the yak milk-derived antioxidant peptide. The DGGY with the amino acid sequence as shown in SEQ ID NO.1 is proposed for the first time, has good antioxidant activity, is high in hydroxyl radical and ABTS free radical scavenging activity, is derived from yak milk, belongs to a natural antioxidant, is good in safety, can be used for preparing antioxidant products, and has wide application prospects.

The invention particularly relates to a ginseng peptide with anti-aging activity and a preparation method and application thereof, and belongs to the technical field of bioactive peptides. The method comprises the following steps: by taking ginseng fibrous roots, ginseng leaves and other by-products as raw materials, carrying out weak acid ultrasonic pretreatment, loading natural anti-aging active components, carrying out low-temperature high-pressure homogenization and airflow crushing synergistic treatment, carrying out double-stage composite enzymolysis, clarifying with an alternating electric field ceramic membrane, carrying out five-stage series ultrafiltration classification, carrying out four-stage filter element sterilization, freeze-drying and the like in sequence. The high-purity ginseng peptide is prepared. The total nitrogen content of the prepared ginseng peptide is larger than or equal to 14.8%, the proportion of a target peptide fragment is larger than or equal to 97.2%, the yield is larger than or equal to 18.5%, and the ginseng peptide has good antioxidant and anti-aging activity and can be used for development of functional food and skin care products. The method is low in cost, high in resource utilization rate and green and efficient in process, and the product purity and activity are remarkably superior to those of a traditional method.

The invention relates to the technical field of biological active peptides, in particular to a method for rapidly and effectively screening light protection active peptides from collagen hydrolysate. The invention relates to an application of a photoprotective polypeptide in preparation of a product. The product has at least one of the following purposes: (1) maintaining or increasing the water content of skin; (2) preventing and / or slowing down skin aging; (3) prevention and / or alleviation of skin UVB injury; and (4) promoting healing of skin wounds or wound surfaces. Two key signal factors (NF-kB, AP-1) and a key matrix metalloproteinase (MMP-9) are screened from a mitogen-activated protein kinase (MAPK) and nuclear factor-kB (NF-kB) pathway to be used as docking targets, and a mimic peptide and the three targets act synergistically to make up for the defect that a single target screening peptide is difficult to comprehensively cope with a light damage multivariate pathway, so that the application of the mimic peptide to the light damage multivariate pathway is realized, and the application of the mimic peptide to the light damage multivariate pathway is realized. And the collagen peptide with excellent light protection activity is obtained through screening.

The invention discloses a ceramide composition capable of promoting cell repair and a preparation method and application thereof, and belongs to the technical field of foods.The ceramide composition is prepared from, by weight, 0.5-2 parts of rice bran oil powder, 0.5-2 parts of salvia officinalis extract and 5-32 parts of bioactive peptide. The bioactive peptides comprise fish collagen peptide, cubilose peptide and sea cucumber peptide, and the weight ratio of the fish collagen peptide to the cubilose peptide to the sea cucumber peptide is (30-55): 1: (1-10). Through the synergistic effect of the rice bran oil powder, the salvia officinalis extract and the bioactive peptide, cell repair is promoted jointly, and efficient repair of a skin barrier is achieved.