707 results about "Bioactive peptide" patented technology

The invention discloses two brand-new bioactive peptides with antioxidant and alpha-glucosidase inhibitory activity in traditional Chinese medicine hippocampus. The sequences of the novel bioactive peptides provided by the invention are respectively YLPPNW and SVWLGGSLL. According to the method, purity and structure identification is carried out on the new bioactive peptide obtained through separation by adopting liquid phase, primary mass spectrum and secondary mass spectrum, and a material basis is provided for further quality control and drug effect research of the traditional Chinese medicine hippocampus.

The invention relates to the technical field of polypropylene plastics, in particular to a high-strength antibacterial polypropylene plastic and a preparation method thereof. The antibacterial polypropylene material comprises the following components in parts by weight: 60-80 parts of polypropylene resin, 5-15 parts of nano titanium dioxide and nano zinc oxide composite particles modified by a special organosilicon polymer, 3-8 parts of an antibacterial agent compounded by quaternary ammonium salt and bioactive peptide, 5-10 parts of a core-shell structure MBS toughening agent and 0.5-2 parts of a hindered phenol-thioether composite antioxidant. 1-3 parts of a calcium stearate processing aid; and 3-8 parts of dopamine modified chopped carbon fibers. The composite material is high in strength, tensile strength, bending strength and impact strength are remarkably improved, and larger external force can be borne; the antibacterial performance is excellent, and the antibacterial rate reaches 95%-99%; the preparation process is environment-friendly and efficient, and the product is good in stability and recoverable; product safety can be guaranteed, the service life is prolonged, and economic and social benefits are good.

The invention discloses a sea cucumber protein heptapeptide with functions of reducing blood pressure and blood sugar and application of the sea cucumber protein heptapeptide, and belongs to the technical field of bioactive peptide biology. The amino acid sequence of the sea cucumber protein heptapeptide is LPPGPFP. The sea cucumber protein heptapeptide can significantly inhibit the activity of ACE through a competitive inhibition mode, tolerates the gastrointestinal tract digestion environment, also has DPP-IV inhibition activity, can relieve hypertension and type 2 diabetes mellitus at the same time, and has an application value in preparation of products with the efficacy of reducing blood pressure and blood sugar due to multiple functions of the sea cucumber protein heptapeptide. The sea cucumber protein heptapeptide provided by the invention can significantly inhibit the activity of ACE through a competitive inhibition mode, has DPP-IV inhibition activity, has the characteristics of simple structure, safety, strong activity and the like, and has a wide application prospect.

The invention relates to the field of preparation and application of biological peptides, in particular to a swelling hippocampal peptide and application of the swelling hippocampal peptide in preparation of anti-fatigue products. Five active peptide sequences with high biological activity are obtained through research, animal behavioral experiments prove that the belly distention hippocampal peptide has a remarkable anti-fatigue effect and can prolong the swimming exhaustion time and enhance the muscle strength, the anti-fatigue effect of the belly distention hippocampal peptide is verified, and a new way is provided for development of anti-fatigue hippocampal products.

The invention discloses a milk-derived polypeptide sequence for promoting skeletal muscle cell proliferation and application of the milk-derived polypeptide sequence, and belongs to the field of bioactive peptides. The milk-derived bioactive polypeptide RHPHPHLSF provided by the invention has the effect of promoting muscle cell proliferation, and is expected to be used for preparing medicines for promoting muscle cell proliferation and preventing sarcopenia. The milk-derived bioactive polypeptide RHPHPHLSF is convenient to synthesize, can be industrially produced, and has a good application prospect in the fields of foods, medicines, cosmetics and the like.

The invention belongs to the field of bioactive peptides. The invention provides an angiotensin converting enzyme inhibitory peptide as well as a screening method and application thereof. The amino acid sequence of the inhibitory peptide is GKGLW and / or GDGLKW. According to the screening method of the ACE inhibitory peptide, the soybean protein is taken as a raw material, and the ACE inhibitory peptide is prepared and screened by adopting a targeted alkaline protease and chymotrypsin double-enzymolysis technology, so that rapid screening of the ACE inhibitory peptide is realized, and an experimental basis is provided for the structure-function relationship of the ACE inhibitory peptide. The inhibitory peptide provided by the invention has strong antihypertensive activity, high safety and no toxic or side effect. Digestive tract stability determination shows that the inhibitory peptide has good gastrointestinal tract stability in gastrointestinal tract digestion, and can still keep good activity after entering blood.

The invention discloses a method for preparing, enriching and separating various egg yolk bioactive peptides through enzymolysis of defatted egg yolk powder and application of the egg yolk bioactive peptides, and belongs to the technical field of egg product processing and bioactive peptides. Egg yolk protein hydrolysate is prepared by adopting a three-step enzymolysis process, adsorption and gradient elution are performed on the egg yolk protein hydrolysate by adopting a macroporous resin chromatographic column, four components including water-1, water-2, 20% ethanol and 80% ethanol are obtained, the water-1 component is common egg yolk peptide, the water-1 component is enriched with osteogenic active peptide, the water-2 component is enriched with ethanol, and the 80% ethanol is enriched with ethanol. The 20% ethanol component enriches antioxidant peptide, and the 80% ethanol component enriches ACE inhibitory peptide. The functional activity of each bioactive peptide component is very strong, and the bioactive peptide component can be used as a high-end functional ingredient. According to the method disclosed by the invention, comprehensive utilization of the degreased yolk powder is realized, enrichment and separation of three active peptides are realized by using one raw material through a step-by-step enzymolysis-directional separation technology, the yield of the active peptides is greatly improved, and the economic benefits of enterprises are improved.

The invention provides a snail bioactive peptide quality tracing system and method based on big data, and belongs to the technical field of snail bioactive peptides. Comprising a data acquisition module used for acquiring various data in the production process of the snail bioactive peptide, a big data processing module used for integrating and cleaning the data, and an intelligent quality analysis module used for analyzing the quality of the snail bioactive peptide. The intelligent quality analysis module is used for carrying out quality prediction and abnormal early warning on the snail bioactive peptide, and the block chain tracing module is used for carrying out quality tracing on the snail bioactive peptide. According to the method, data islands of cultivation, production and detection links can be broken, cross-link association analysis is realized, manual sampling inspection is upgraded to AI-driven real-time early warning and process optimization, data authenticity is guaranteed through a block chain technology, international compliance requirements are met, and consumer trust and brand price are improved by adopting three-dimensional visualization and scientific data.

The invention discloses a wheat peptide with a function of promoting peristalsis as well as a preparation method and application of the wheat peptide, and belongs to the technical field of biological medicines. The wheat peptide is obtained by directional enzymolysis of wheat protein and contains hexapeptide TR6 with the amino acid sequence of Thr-Ser-Val-Pro-Phe-Arg, functional verification shows that the hexapeptide TR6 and the wheat peptide containing the peptide fragment have the function of promoting peristalsis, the function is mainly reflected in shortening the time interval of peristalsis peaks and improving the peristalsis promoting rate, and the function of promoting the peristalsis is achieved. And the food-borne bioactive peptide is high in biological safety. Therefore, the compound can be applied to the preparation of food or medicines for improving the peristalsis disorder. The invention provides a new solution for improving the peristalsis disorder, and has good market prospect and application potential.

The invention discloses ACE (Angiotensin Converting Enzyme) inhibitory octapeptide YI8 derived from bovine cheese protein hydrolysate and application, and relates to the technical field of bioactive peptides, and the technical scheme is characterized in that the ACE inhibitory octapeptide YI8 comprises an amino acid sequence of YKVPQLEI. The ACE inhibitory octapeptide YI8 derived from the cattle cheese protein hydrolysate is obtained by screening from the cattle cheese protein hydrolysate, and is an octapeptide YI8 with ACE inhibitory activity, the in-vitro ACE inhibition rate of the ACE inhibitory octapeptide YI8 derived from the cattle cheese protein hydrolysate is tested to be 70.86% under the condition of the concentration of 1mg / ml, and the ACE inhibitory octapeptide YI8 is suitable for functional food for assisting in lowering blood pressure.

The invention relates to the technical field of bioactive peptides, in particular to an antioxidant peptide based on mussel byssus, a preparation method, a preparation and application of the antioxidant peptide based on mussel byssus, the antioxidant peptide is designed and synthesized by referring to the structural characteristics of mussel byssus proteins mfp-3, mfp-5 and mfp-6, the antioxidant peptide comprises four sequences of MFP3-AP1, MFP5-AP2, MFP6-AP3 and MFP-Hybrid, tyrosine in the peptide is modified into DOPA through enzymatic modification, and the antioxidant peptide is prepared through enzymatic modification. The stability and activity of the antioxidant peptide are enhanced through disulfide bond formation, metal ion coordination, PEGylation and other modifications, and the antioxidant peptide has high DPPH free radical scavenging activity, ABTS free radical scavenging activity, hydroxyl free radical scavenging activity and iron ion reducing capacity, has a protective effect on the cellular level, can be prepared into a liquid preparation, a freeze-dried preparation or a micro-capsule preparation, and can be used for preparing the antioxidant peptide. The compound is expected to be applied to the fields of antioxidant health care products, cosmetics and medicines.

The invention discloses a hemp seed protein source pancrelipase inhibitory peptide as well as a preparation method and application thereof, and belongs to the technical field of bioactive peptides. The hemp seed protein source pancrelipase inhibitory peptide provided by the invention has an amino acid sequence as shown in SEQ ID NO. 1 (YNLPILRF). The cannabis sativa L. protein source pancreatic lipase inhibitory peptide provided by the invention is separated from cannabis sativa L. protein for the first time, is a novel cannabis sativa L. protein source pancreatic lipase inhibitory peptide, has good pancreatic lipase inhibitory activity, can be used as a natural anti-obesity agent in food, health care products and weight control related drugs, and has broad application prospects. Good application prospects are realized.

The invention discloses a wheat peptide with a hypoglycemic effect as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention provides a bioactive peptide LPQ or LPQF with a hypoglycemic effect, and animal model experiments prove that the bioactive peptide can effectively reduce the blood sugar level and improve related metabolic indexes, and has no obvious side effects. The invention also provides a wheat peptide rich in oligopeptide containing the peptide fragment LPQ, and animal model experiments prove that the wheat peptide has a remarkable effect in the aspect of reducing blood sugar. The invention provides a safe and effective alternative scheme for development of diabetes treatment drugs, and has good market prospects and application potential.

The invention discloses a yolk protein source tripeptide with a function of improving osteoporosis and application of the yolk protein source tripeptide, and belongs to the technical field of biological medicines. The tripeptide is a tripeptide APW of which the amino acid sequence is Ala-Pro-Trp. The peptide fragment can be obtained through artificial synthesis or directional enzymolysis of defatted yolk powder. Functional verification shows that the tripeptide APW and the egg yolk protein hydrolysate containing the peptide fragment have the function of improving the bone mineral density, and in a zebra fish osteoporosis model, when the egg yolk protein hydrolysate is 20 mu g / mL, the bone mineral density is improved by 58%; when the tripeptide APW is 0.5 mu g / mL, the bone mineral density is increased by 23.4%; in a rat osteoporosis model, the bone mineral density of thighbone is increased by 3.39% after 10 mg / kg. D of egg yolk protein enzymatic hydrolysate is eaten. Moreover, the food-borne bioactive peptide is high in biological safety, so that the tripeptide APW and a yolk protein enzymolysis product containing the peptide fragment can be applied to preparation of medicines for treating osteoporosis or health-care foods for improving bone mineral density, and the tripeptide APW has a good market prospect and application potential.

The present invention discloses small molecule active peptides, compositions and their use in preparing products with antioxidant and hypoglycemic effects, belonging to the technical field of bioactive peptides. The amino acid sequence of the small molecule active peptide of the present invention is at least one of DQFPR, LDQFPR and SYGLPR. The present invention separates and purifies a plurality of small molecule active peptides with antioxidant and hypoglycemic effects from peanut protein, chemically synthesizes the identified peptide sequences, and detects the antioxidant activity and hypoglycemic activity of the single peptide segment and the composite peptide segment of the synthetic peptide segment. The small molecule active peptide and its composite peptide segment both have good free radical scavenging and ɑ-glucosidase and ɑ-amylase inhibitory effects, and have good application prospects in the preparation of products with antioxidant and hypoglycemic effects, laying a foundation for the high added value utilization of peanut protein and the promotion of the research and development and application of functional active peptides.

The invention relates to the technical field of bioactive peptides, in particular to a novel multifunctional collagen-like tripeptide and application thereof, an amino acid sequence contains multiple combinations, X can be selected from multiple components, 3-methoxy-4-hydroxyphenylalanine and the like are added, and the novel multifunctional collagen-like tripeptide can interact with specific proteins, activate related pathways and play multiple physiological functions and is applied to multiple fields. The collagen-like tripeptide has obvious advantages, innovates component expansion functions, improves the preparation method, improves the efficiency, reduces the cost, is matched with other components in the fields of beauty, health care and medicine, enhances the efficacy, realizes targeted delivery, and brings a new opportunity to related industries.

The invention discloses a sesame umami peptide with antioxidant activity and application thereof, the amino acid sequence of the sesame umami peptide is at least one of GFE (Gly-Phe-Glu), YMD (Tyr-Met-Asp) and RFT (Arg-Phe-Thr), and the sesame umami peptide belongs to the technical field of bioactive peptides. Three novel umami peptides are found and identified from sesame protein in combination with virtual enzymolysis, directional screening and molecular docking, sensory evaluation and electronic tongue analysis prove that the umami peptides GFE, YMD and RFT have good umami characteristics and have a good umami increasing effect on sodium glutamate, the umami threshold value is 0.07-0.36 mmol / L, and meanwhile, the three umami peptides all have antioxidant activity. The novel umami peptide is excavated from the sesame, the utilization value of sesame byproducts can be improved, the extracted umami peptide can also be used as a flavor enhancer or applied to preparation of the flavor enhancer, a new raw material basis is provided for development of the flavor enhancer, seasonings and functional food, and good application prospects and important application value are achieved.

The invention provides a coding gene of coral-derived anticoagulant polypeptide and application, and belongs to the technical field of bioactive peptides. The invention provides an anticoagulant polypeptide GcKuz1. The anticoagulant polypeptide GcKuz1 comprises a mature peptide fragment as shown in SEQ ID No.1. The invention also provides a preparation method of the anticoagulant polypeptide GcKuz1. The polypeptide GcKuz1 is combined with KLKB1 in a thrombin system, so that the anti-thrombus and anti-coagulation effects are achieved, and the polypeptide does not cause hemolysis and cytotoxicity, has no bleeding risk and has good biological safety. The anticoagulant polypeptide disclosed by the invention has the effect of treating thrombotic diseases, such as arterial thrombotic diseases, venous thrombotic diseases and capillary thrombotic diseases.

The invention discloses a tortoise shell bioactive peptide and a preparation method and application thereof.The tortoise shell bioactive peptide comprises one or more of EHTVVY, GPKKDQK, SPLSDVRGH, SENADKGALS and DPKMNGLK. The preparation method comprises the steps of preparation of tortoise shell protein hydrolysate, ultrafiltration separation, anion exchange resin separation, gel column separation, de novo sequencing analysis, molecular docking screening and solid-phase synthesis. The tortoise shell bioactive peptide can be applied to the fields of oxidation resistance and immunoregulation. The method disclosed by the invention is a separation, purification and identification technical method of the tortoise shell specific antioxidant polypeptide based on activity guidance, and has the advantages of clear components, clear activity, clear mechanism and the like; the obtained specific polypeptide has important significance for functional product development of polypeptide compounds with clear tortoise shell components.

The invention relates to the field of preparation and application of biological peptides, in particular to a swelling hippocampal peptide and application thereof in preparation of uric acid reducing and gout resisting products. The amino acid sequence is shown as SEQ ID NO.1-5. The uric acid reducing effect is verified by adopting an in-vitro XOD inhibition experiment and a cell experiment; furthermore, the uric acid reducing and gout resisting activity of the compound is verified through a hyperuricemia animal model, and a theoretical basis is provided for high-valued utilization of the belly-swelling hippocampus and development of uric acid reducing and gout resisting products.

The invention discloses a fish by-product active peptide, a preparation and application, and belongs to the technical field of biological active peptides. The amino acid sequences of the fish by-product active peptide are shown as SEQ ID NO: 1 to SEQ ID NO: 3. Both the single peptide fragment and the compound peptide fragment of the fish by-product active peptide can obviously inhibit NO secretion of a lipopolysaccharide (LPS)-induced macrophage (RAW264.7) inflammation model, so that the fish by-product active peptide has a relatively good application prospect in preparation of a product with an anti-inflammatory effect; and a foundation is laid for high-added-value utilization of salmon byproducts and promotion of research, development and application of functional active peptides.

The invention relates to the technical field of bioactive peptides, and particularly discloses a peptide oxidation resistance prediction method and system based on a pre-training model and descriptors, and the method comprises the following steps: obtaining an amino acid sequence of a to-be-predicted polypeptide and a physicochemical characteristic description index of each amino acid; enabling the coded amino acid sequence to pass through a BERT embedding layer to form high-dimensional vector representation, inputting the high-dimensional vector representation into a pre-trained deep neural network model to obtain features of a peptide sequence, and inputting the features of the peptide sequence into a pre-trained artificial neural network to obtain deep representation of the peptide sequence; according to the physicochemical characteristic description index of each amino acid, generating a characteristic vector of each amino acid, and constructing the characteristic of the polypeptide; and inputting the depth representation of the peptide sequence and the characteristics of the polypeptide into a predictor to obtain a prediction result of the oxidation resistance of the peptide. According to the method, the fine-tuned model characterization is combined with the traditional peptide sequence descriptor, so that the prediction accuracy of the antioxidant peptide and the stability of the model are successfully improved.

Methods and compositions are disclosed for treating and preventing cytokine release syndrome (CRS). acute respiratory distress syndrome (CRS), and alveolar capillary injury (ACI) in a subject.

The embodiment of the invention relates to a phycobiliprotein active peptide with a hypoglycemic function and a preparation method and application thereof, and belongs to the technical field of biological active peptides. According to the phycobiliprotein active peptide with the blood sugar reducing function, the amino acid sequence of the phycobiliprotein active peptide is Ser-Tyr-Phe-Asp-Arg-Ala, Ile-Ala-Ser-Tyr-Phe-Asp-Arg, Gly-Tyr-Tyr-Leu-Arg or Val-Ala-Phe-Gly-Arg-Phe, and the amino acid sequence of the phycobiliprotein active peptide with the blood sugar reducing function is shown in the description. The phycobiliprotein active peptide in the embodiment of the invention is separated from spirulina phycobiliprotein, and the spirulina phycobiliprotein is an important protein resource in spirulina and a high-quality source of bioactive peptide, and has wider application; the phycobiliprotein active peptide is low in molecular weight, and compared with a chemically synthesized hypoglycemic preparation, food-borne peptides are safer and more efficient, free of toxic and side effects and easy to digest and absorb; the phycobiliprotein active peptide has high binding affinity with the alpha-glucosidase and the DPP-IV, can form a very stable ligand receptor compound, and has a good inhibition effect on the alpha-glucosidase and the DPP-IV; the compound has excellent inhibition performance on alpha-glucosidase, alpha-amylase and DPP-IV (dipeptidyl peptidase-IV).

The invention belongs to the technical field of plant extracts, and particularly relates to application of a carob bean extract in a medicine for improving glycometabolism / female polycystic ovarian syndrome. The invention discloses a pharmaceutical composition for improving glycometabolism female polycystic ovarian syndrome. The pharmaceutical composition is prepared from a carob bean extract, baicalein, cedrol, bioactive peptide, biological polysaccharide and auxiliary materials. The composition disclosed by the invention has the effects of reducing blood sugar, reducing blood fat and improving an insulin function, and also has the effects of resisting oxidation, enhancing immunity and the like, and the substances are combined for use, so that a synergistic interaction effect is achieved, and the effect of improving / treating the abnormal glucose metabolism related female polycystic ovarian syndrome is further improved.

The invention belongs to the technical field of preparation of postbiotics, and discloses a preparation method and application of lactic acid bacteria fermented Chinese chestnut protein postbiotics for improving systemic chronic inflammations, Chinese chestnuts are subjected to shelling, grinding and degreasing treatment, and degreased Chinese chestnut powder is obtained; resuspending the degreased Chinese chestnut powder in distilled water, adjusting the pH value, and stirring; performing solid-liquid separation and magnetic stirring; carrying out solid-liquid separation, resuspending and adjusting the pH value; dialyzing to obtain Chinese chestnut protein powder; mixing with glucose powder, and redissolving in distilled water; and mixing with lactic acid bacteria and carrying out aerobic fermentation to obtain the Chinese chestnut protein metaplasm product. The bioactive peptides contained in the Chinese chestnut protein metaplasm prepared by the method have potential anti-inflammatory activity, can effectively inhibit proinflammatory medium secretion of macrophages and intestinal epithelial cells, and improve glucose and lipid metabolism disorder and intestinal barrier function damage related to chronic inflammation of a body. The bioactive peptide contained in the postbiotic product disclosed by the invention has an anti-inflammatory effect.

The invention discloses a method for preparing various bioactive peptides based on bean dreg fermentation, which comprises polypeptides with alpha-glucosidase inhibitory activity, angiotensin converting enzyme inhibitory activity and antioxidant activity, and belongs to the field of microbial biological fermentation. Bacillus amyloliquefaciens sourced from fermented soybeans is used for fermentation, and a mixed product with alpha-glucosidase inhibitory activity, angiotensin converting enzyme inhibitory activity and antioxidant activity is obtained. The invention also provides a method for purifying the polypeptide with alpha-glucosidase inhibitory activity, angiotensin converting enzyme inhibitory activity and antioxidant activity, which is characterized in that the mixed product is purified by combined column chromatography, the combined column chromatography comprises cation exchange resin LXP-01, macroporous adsorption resin HP20, weak base anion exchange resin D941, silica gel resin and Sephadex LH-20. The invention also discloses seven bioactive peptides with biological activity, the amino acid sequences are CKLLL, APGYSC, FPKYG, FPGPLV, FPRSH, FMAV and SVCC, and the bioactive peptides have good alpha-glucosidase inhibitory activity, angiotensin converting enzyme inhibitory activity and antioxidant activity, and can be used for producing functional foods, health care products, cosmetics and the like for assisting in reducing blood sugar, reducing blood pressure, resisting oxidation and the like.

The invention discloses a preparation method of composite lipopeptide capable of preventing high-temperature inactivation, and belongs to the technical field of bioactive peptide preparation. The preparation method comprises the following steps: mixing and dissolving a modified phospholipid compound, cholesterol and chloroform, and performing rotary evaporation to obtain a lipid film; mixing and shaking the lipid film, the lipopeptide mixture and a phosphate buffer solution, and performing ultrasonic treatment to obtain a composite lipopeptide liposome suspension; and carrying out spray drying on the composite lipopeptide liposome suspension to obtain composite lipopeptide powder. A lipopeptide mixture obtained through fermentation is mixed with a modified phospholipid compound and cholesterol, a high-temperature-resistant composite lipopeptide liposome suspension is constructed, and after high-temperature spray drying, the obtained composite lipopeptide still has good antibacterial activity.

The invention discloses a blood protein precise active peptide capable of tonifying qi and blood, improving microcirculation and promoting vasodilation and a preparation method and application thereof, and belongs to the technical field of blood protein peptide. The blood protein precision active peptide comprises at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII or FPHFD. The prepared blood protein precision active peptide has multiple biological activities: an antihypertensive effect is achieved by inhibiting ACE and vasoconstriction substances; vasodilation is promoted by activating a PI3K / AKT / eNOS signal channel; a zebra fish model proves that the traditional Chinese medicine composition has the effects of remarkably improving microcirculation and tonifying qi and blood. The preparation method is low in equipment requirement, simple in process, easy to operate and convenient for industrial large-scale production. The method enriches a bioactive peptide library, and is of great significance in promoting technical progress and industrial upgrading in the field of hemoglobulin peptides.

The invention discloses ACE (Angiotensin Converting Enzyme) inhibitory decapeptide IR10 derived from bovine cheese protein hydrolysate and application of the ACE inhibitory decapeptide IR10, and relates to the technical field of bioactive peptides, and the technical scheme of the ACE inhibitory decapeptide IR10 is characterized in that the amino acid sequence is IQKEDVPSER. The ACE inhibitory decapeptide IR10 derived from the cattle cheese protein hydrolysate is obtained by screening from the cattle cheese protein hydrolysate and is decapeptide IR10 with ACE inhibitory activity, the in-vitro ACE inhibition rate of the ACE inhibitory decapeptide IR10 derived from the cattle cheese protein hydrolysate is tested to be 62.07% under the condition of the concentration of 1mg / ml, and the ACE inhibitory decapeptide IR10 has the effect of being suitable for functional food for assisting blood pressure reduction.