328 results about "Hypoglycemic Effects" patented technology

The invention provides application of polygonatum cyrtonema polysaccharide in preparation of medicines for treating ulcerative colitis or reducing blood glucose. A main chain of a sugar chain structure of the homogeneous polysaccharide PCP2 in polygonatum cyrtonema is mainly composed of-> 1)-beta-D-Fur-(2->,-> 1, 6)-beta-D-Fur-(2-> and-> 6)-alpha-D-Glcp-(1-> and beta-D-Fur-(2->), a side chain is mainly composed of beta-D-Fur-(2-> and-> 2)-beta-D-Fur-(6-> at a C-6 position of-> 1, 6)-beta-D-Fur-(2->), Fur represents furanose, Glcp represents glucopyranose, Glcp represents glucopyranose, and Glcp represents glucopyranose. The novel polysaccharide compound can relieve intestinal injury of mice, increase expression of tight nectin and mucoprotein, relieve oxidative stress reaction, promote production of short-chain fatty acid and improve composition of intestinal flora, and can be applied to the field of medicine as a medicine for treating ulcerative colitis. Meanwhile, the homogeneous polysaccharide PCP2 in polygonatum cyrtonema can significantly inhibit the activity of alpha-amylase and alpha-glucosidase, can also promote the ability of insulin resistance 3T3-L1 fat cells to uptake and consume glucose, shows a significant hypoglycemic effect, and has a good development prospect in the aspect of preparation of hypoglycemic drugs.

The invention provides homogenized pitaya polysaccharide as well as a preparation method and application thereof, and belongs to the technical field of polysaccharide extraction and purification. The homogenized pitaya polysaccharide is a polysaccharide of which the monosaccharide is composed of mannose, glucosamine hydrochloride, rhamnose, glucuronic acid, galacturonic acid, glucose, galactose and arabinose, the relative molecular weight is 8.08 * 10 < 4 > Da, and the corresponding molar ratio is (0.181): (0.250): (16.544): (12.762): (3.793): (0.739): (51.014): (14.716). The invention further provides a preparation method of the homogenized pitaya polysaccharide and application of the homogenized pitaya polysaccharide in preparation of lipid-lowering and sugar-lowering drugs. The homogenized pitaya polysaccharide disclosed by the invention has an obvious lipid-lowering and blood-glucose-reducing effect, is from a natural product, so that the homogenized pitaya polysaccharide has no toxic or side effect and can be used for preparing lipid-lowering and blood-glucose-reducing medicines.

The invention relates to a bifidobacterium animalis subsp. Lactis YYSJ001 with a blood sugar reducing effect and application of the bifidobacterium animalis subsp. Lactis YYSJ001. The classification name of the strain is bifidobacterium animalis subsp. Lactis, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.33471. The invention further relates to a preparation method of the bifidobacterium animalis subsp. Lactis YYSJ001. The bacterial strain has good artificial gastric juice resistance, artificial intestinal juice resistance and intestinal tract adhesion ability, has an inhibition effect on numerous pathogenic bacteria such as escherichia coli, staphylococcus aureus, salmonella, klebsiella pneumoniae and quail chicken enterococcus, and can stimulate intestinal cells to generate glucagon-like peptide-1, so that the bacterial strain can be applied to preparation of various pathogenic bacteria. Diseases of diabetic mice can be effectively improved, and the compound can be used for preparing products for preventing and treating diabetes or assisting in reducing blood sugar.

The invention discloses a semaglutide soluble microneedle patch composition. The soluble microneedle patch composition comprises a needle body material and a backing layer material, the material of the needle body can be only composed of a high-concentration semaglutide solution. According to the semaglutide micro-needle patch, the drug loading capacity of semaglutide in the micro-needle patch can be greatly improved, the hypoglycemic effect which is the same as that of subcutaneous injection administration can be achieved under the same administration amount, and a new dosage form choice is provided for the pharmaceutical application of semaglutide, such as hypoglycemic weight reduction and the like.

The invention discloses an ACE (Angiotensin Converting Enzyme) inhibition and DPP-IV (Dipeptidyl Peptidase-IV) inhibition bifunctional peptide as well as a design method and application thereof. The amino acid sequence of the bifunctional peptide fragment is Trp-Ala-Leu-Val-Ala-Pro or Trp-Pro-Leu-Val-Ala-Pro. According to the design method, hydrophobic amino acid replacement is carried out on most N-terminal first amino acid according to the characteristics of the DPP-IV inhibitory peptide, and N-terminal second amino acid is kept as proline Pro or alanine Ala. The difunctional peptide fragment obtained through the DPP-IV inhibitory activity optimization strategy has the effects of assisting in lowering blood pressure and lowering blood sugar at the same time and can be used for preparing functional food or health food with the functions of assisting in lowering blood pressure and lowering blood sugar, and the optimization strategy can be applied to improving the blood sugar lowering effect of the peptide fragment and has good market application prospects.

The invention discloses a preparation method of magnesium acetyltaurate and application of the magnesium acetyltaurate in preparation of hypoglycemic drugs or health care products, research finds that magnesium acetyltaurate has an obvious hypoglycemic effect, and results of repeated verification of mouse sugar tolerance animal experiments of single-time administration and multiple-time administration of magnesium acetyltaurate prove that the magnesium acetyltaurate has the obvious hypoglycemic effect. The magnesium acetyltaurate can reduce the blood sugar level of the mouse, basically has no influence on the weight of the mouse, can be used as a medicine for reducing the blood sugar, and has good development and application prospects. The preparation method disclosed by the invention is simple to operate and low in cost, and large-scale preparation of magnesium acetyltaurate can be realized.

The invention discloses a bioactive peptide with antioxidant and hypoglycemic functions, a composition and application, and belongs to the technical field of bioactive peptides. The amino acid sequence of the bioactive peptide with the antioxidant and hypoglycemic functions is as shown in one of SEQ ID NO: 1-SEQ ID NO: 4. According to the method, the degreased peanut meal is subjected to enzymolysis by combining multiple enzymes, so that the diversity of peptide fragments is improved, and a high-activity enzymolysis product is obtained through condition optimization. An enzymolysis product is separated and purified by utilizing an ultrafiltration and high performance liquid chromatography-mass spectrometry combined technology, so that the purity and the structural definition of the peptide fragment are ensured. The bioinformatics technology is combined for screening, so that the activity and effect of the peptide sequence are improved. In-vitro and in-vivo experiments prove that the separated bioactive peptide has good antioxidant and hypoglycemic effects, and has a wide application prospect in preparation of antioxidant and hypoglycemic products.

The invention discloses a wheat peptide with a hypoglycemic effect as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention provides a bioactive peptide LPQ or LPQF with a hypoglycemic effect, and animal model experiments prove that the bioactive peptide can effectively reduce the blood sugar level and improve related metabolic indexes, and has no obvious side effects. The invention also provides a wheat peptide rich in oligopeptide containing the peptide fragment LPQ, and animal model experiments prove that the wheat peptide has a remarkable effect in the aspect of reducing blood sugar. The invention provides a safe and effective alternative scheme for development of diabetes treatment drugs, and has good market prospects and application potential.

The invention discloses a hexapeptide with a hypoglycemic effect as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The amino acid sequence of the hexapeptide is Ile-Trp-Asp-Pro-His-Phe, and the amino acid sequence of the hexapeptide is as shown in the specification. The novel hexapeptide IWDPHF with prominent DPP-IV inhibition ability is successfully identified from mulberry leaf proteolysis products through liquid chromatography-mass spectrometry and a virtual screening method, the hexapeptide IWDPHF shows the blood glucose reducing effect superior to that of part of known peptides in an in-vitro enzyme activity inhibition experiment and a zebra fish hyperglycemia model, and no obvious side effect exists; the compound has a good potential of being developed into a hypoglycemic functional product or a drug lead compound. The invention further provides the mulberry leaf peptide with the peptide fragment IWDPHF, and the mulberry leaf peptide can be applied to preparation of drugs or food for reducing blood sugar. The invention provides a new scheme and theoretical basis for treatment of diabetes, and has good market prospect and application potential.

The invention discloses a small-molecule active peptide, a composition and application of the small-molecule active peptide in preparation of a product with antioxidant and hypoglycemic effects, and belongs to the technical field of biological active peptides. The amino acid sequence of the small molecule active peptide is at least one of DQFPR, LDQFPR and SYGLPR. According to the invention, a plurality of small molecule active peptides with antioxidant and hypoglycemic effects are obtained by separating and purifying peanut protein, the identified peptide fragment sequence is chemically synthesized, and the antioxidant activity and hypoglycemic activity of a single peptide fragment and a compound peptide fragment of the synthesized peptide fragment are detected. The small molecule active peptide and the compound peptide fragment thereof have good effects of scavenging free radicals and inhibiting alpha-glucosidase and alpha-amylase, and have good application prospects in preparation of products with antioxidant and hypoglycemic effects; and a foundation is laid for high-added-value utilization of the peanut protein and promotion of research, development and application of functional active peptides.

The invention belongs to the technical field of plant active peptides, and particularly relates to a red kidney bean hypoglycemic active peptide and application thereof. The amino acid sequences of the hypoglycemic active peptide are FFGGPAF, SAKPFFSGL and PPGHPFVTF. The invention further discloses a preparation method of the hypoglycemic active peptide. FF, SL and PF for short. The polypeptide is prepared through enzymolysis of red kidney bean protein, and the polypeptide is identified by utilizing ultrafiltration separation and LC-MS / MS (Liquid Chromatography-Mass Spectrometry / Mass Spectrometry); the hypoglycemic active peptides which are high in hypoglycemic effect, free of toxicity, carcinogenicity and sensitization and capable of being absorbed by human intestinal tracts are screened out through a bioinformatics method and molecular docking, then the screened hypoglycemic active peptides and alpha-glucosidase are subjected to molecular docking, and finally three hypoglycemic active peptides FF, SL and PF are screened out. The invention finds that the hypoglycemic active peptides FF, SL and PF have high inhibitory activity on alpha-glucosidase, can obviously promote glucose consumption of insulin resistance model cells, and can be used for preparing hypoglycemic drugs, food and health care products.

The invention discloses a small-molecule active peptide with antioxidant and hypoglycemic effects, a composition and application, and belongs to the technical field of biological active peptides. The amino acid sequence of the small molecule active peptide with the antioxidant and blood sugar reducing effects is at least one of FSNAPRL, QFGRLY and SVPGHF. According to the invention, a plurality of micromolecular active peptides with antioxidant and hypoglycemic effects are extracted from walnut meal, the obtained peptide fragment sequence is subjected to molecular docking and chemical synthesis, and the antioxidant activity and hypoglycemic activity of a single peptide fragment and a compound peptide fragment of the synthesized peptide fragment are verified. The active peptide and the compound peptide fragment thereof have good DPPH and ABTS clearance rate and alpha-glucosidase and alpha-amylase inhibition ability, so that the active peptide and the compound peptide fragment thereof have good application prospects in preparation of products with antioxidant and hypoglycemic effects, and a foundation is laid for comprehensive utilization of walnut meal byproducts and promotion of research, development and application of functional active peptides.

The invention provides a fat-reducing composition based on an agaricus bisporus extract as well as a preparation method and application of the fat-reducing composition, and belongs to the technical field of nutrition and health care. The fat-reducing composition comprises the following raw materials in parts by weight: 10-30 parts of an agaricus bisporus extract, 5-15 parts of a green tea extract, 5-15 parts of bitter gourd peptide, 3-10 parts of seaweed meal and 10-30 parts of resistant dextrin. The agaricus bisporus extract disclosed by the invention can regulate intestinal flora and promote fat metabolism; tea polyphenol in the green tea extract can inhibit fat synthesis and promote fat oxidation; momordica charantia peptide has an obvious hypoglycemic effect; the seaweed meal (containing fucoxanthin) has the effects of burning fat cells and eliminating fat accumulation; the resistant dextrin is used as dietary fiber, so that satiety is increased, and caloric intake is reduced. The raw materials cooperate with each other, so that the composition has better fat-reducing and weight-reducing effects, and the total cholesterol and triglyceride levels are reduced.

The invention relates to the technical field of microorganisms, in particular to lactobacillus paracasei 1A74 and application of the lactobacillus paracasei 1A74 in reducing blood sugar. Compared with other lactic acid bacteria, the lactobacillus paracasei strain and a microbial agent have the advantages that fermented supernate (CFS) and cell disruption matter supernate (CFE) both have an inhibition effect on alpha-glucosidase and dipeptidyl peptidase IV, and the lactobacillus paracasei strain and the microbial agent have the inhibition effect on the alpha-glucosidase and the dipeptidyl peptidase IV; compared with other lactic acid bacteria strains, the lactic acid bacteria strain has a better hypoglycemic effect than other lactic acid bacteria strains, the bacterial strain is used for preparing buffalo fermented milk, the texture of the fermented milk can be remarkably improved through synergistic interaction with a leavening agent, and the siraitia grosvenorii fermented milk beverage prepared from the bacterial strain can remarkably improve the alpha-glucosidase inhibition rate and the oxidation resistance of the product. Therefore, the strain provided by the invention is a multi-effect bacterium which can be improved on the whole line in multiple aspects of inhibiting the activity of key enzymes related to blood glucose, improving the texture quality and the like, and has wide popularization and development values.

The invention discloses a polysaccharide compound of Alsophila spinulosa and an extraction method and application thereof, wherein the polysaccharide compound is composed of rhamnose, arabinose, galactose and glucuronic acid. The polysaccharide compound of the invention is derived from mature leaves of Alsophila spinulosa, and is extracted by water extraction and alcohol precipitation, crude polysaccharide impurity removal, DEAE seplife FF ion column separation, and Sephacryl S‑400HR gel column purification. The method is simple and fast to operate, and water extraction and anhydrous ethanol precipitation are mainly used in the extraction and separation process. The process method is environmentally friendly, and the purity of the compound separated by the method is relatively high, all greater than 92%. The extracted polysaccharide compound has been found to have a significant hypoglycemic effect through research, and can be used as a raw material for new drug development and pharmacological activity research, and can also be used for food additives or health care product development.

The invention discloses a photocuring microneedle with ginseng exosome loaded berberine, a preparation method of the photocuring microneedle and application of the photocuring microneedle to tissue repair. A ginseng exosome loaded berberine compound is prepared through a microfluidic technology; filling a needle cavity of a microneedle mold with a needle tip layer preparation solution containing the compound, methylacryloylated hyaluronic acid and methylacryloylated gelatin through a centrifugal method; covering a backing layer preparation solution composed of hyaluronic acid and povidone K90, and centrifuging again; and finally, carrying out light curing, drying and demolding. The prepared composite microneedle is complete and sharp in needle shape and high in forming rate; the efficient entrapment of the active medicine is realized; the biocompatibility is good, and the irritation is low; a cross-linked network structure formed by photocuring is beneficial to realizing controlled release of drugs, the targeted repair function of the ginseng exosome is combined with the hypoglycemic effect of berberine, and a new strategy and technical approach with a prospect are provided for painless, efficient and long-acting treatment of diabetes mellitus.

The invention relates to the technical field of microorganisms, in particular to lactobacillus rhamnosus ZKLGG0310, dendrobium officinale fermentation liquor of the lactobacillus rhamnosus ZKLGG0310 and application of the lactobacillus rhamnosus ZKLGG0310 to preparation of hypoglycemic drugs, the lactobacillus rhamnosus ZKLGG0310 is preserved in the China General Microbiological Culture Collection Center on May 13, 2024, the preservation address is No. 3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC NO. The preservation number is CGMCC (China General Microbiological Culture Collection Center) The lactobacillus rhamnosus ZKLGG0310 is used for fermenting the dendrobium officinale extracting solution, the blood glucose reducing effect of dendrobium officinale is remarkably improved, meanwhile, lipid metabolism is adjusted, and complications of type 2 diabetes mellitus are relieved.

The invention provides a rehmannia fermented extract, a composition as well as a preparation method and application of the rehmannia fermented extract and the composition, and belongs to the technical field of biological medicines. According to the invention, raw dark green tea and rehmannia are fermented by using a single strain of eurotium cristatum to respectively obtain a raw dark green tea fermentation extract and a rehmannia fermentation extract. Experiments prove that the two extracts have a relatively good inhibition effect on dipeptidyl peptidase-4 when being independently used; furthermore, the two extracts are combined, and animal experiments prove that the composition has relatively good inhibitory activity on intestinal tract and excrement dipeptidyl peptidase-4 and also has a hypoglycemic effect.

The invention provides a healthy food, in particular to a hypoglycemic composition based on homology of medicine and food and gradient fermentation type prebiotics, which is a dry powder preparation and comprises a component A and a component B, the component A is a medicinal and edible component, and the component B is a prebiotic component; the component A is prepared from the following components in parts by mass: 2 to 15 parts of folium mori extract, 2 to 10 parts of bitter gourd extract, 2 to 20 parts of rhizoma dioscoreae extract, 1 to 10 parts of radix puerariae extract, 2 to 10 parts of fructus lycii extract, 0.5 to 5 parts of radix polygonati officinalis extract and 0.5 to 5 parts of rhizoma polygonati extract; the component B is prepared from 20 to 50 parts of resistant dextrin, 5 to 15 parts of xylooligosaccharide, 3 to 10 parts of inulin and 35 to 50 parts of D-psicose. The hypoglycemic activity of the traditional medicinal and edible materials is organically combined with the gradient fermentation type prebiotics, so that the hypoglycemic effect is realized by synergism of multiple action mechanisms, and the problems of single hypoglycemic mechanism and non-ideal blood sugar regulation effect of the existing product are solved.

The invention discloses a marine-derived bioactive peptide with a blood sugar reducing effect, a preparation and application, and belongs to the technical field of bioactive peptides. The amino acid sequence of the bioactive peptide is at least one of FYP, FPF and YAPFPK. Three bioactive peptides with the blood sugar reducing effect are separated and purified from oysters through enzymolysis, ultrafiltration, gel chromatography, liquid chromatography-mass spectrometry and bioinformatics technologies. According to the present invention, chemical synthesis is performed according to the identified peptide fragment sequence, the hypoglycemic activity of the synthesized single peptide fragment and the compounded peptide fragment is detected, and the bioactive peptides have good alpha-glucosidase inhibition activity, such that the bioactive peptides have good application prospects in the preparation of the products with the hypoglycemic effect, and can be widely used in the preparation of the products with the hypoglycemic effect. And a foundation is laid for high value-added utilization of oysters and promotion of research, development and application of functional active peptides.

The invention discloses an application of an HMMR ligand. According to the application, new application of the HMMR ligand is found, and the HMMR ligand can regulate and control ERK to inhibit a gluconeogenesis pathway, so that the HMMR ligand has potential to be used as a diabetes treatment drug; the application also finds that the FCN3 protein or the derivative thereof can be used as an HMMR ligand to be combined with a membrane receptor HMMR, regulate ERK to inhibit a gluconeogenesis pathway, reduce expression of gluconeogenesis related genes and reduce the liver gluconeogenesis level, so that the liver sugar production is reduced, and the FCN3 protein or the derivative thereof has a very remarkable long-acting hypoglycemic effect; besides, the polypeptide newly designed in the invention shows a better hypoglycemic effect, is smaller in molecule and convenient to prepare, and is a high-potential lead molecule for treating diabetes, especially type 2 diabetes.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition with a hypoglycemic effect and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-23 parts of astragalus membranaceus, 12-18 parts of sambucus chinensis root, 10-15 parts of dogwood, 5-8 parts of wormwood stem, 1-5 parts of camptotheca acuminata fruit, 1-5 parts of cyclocarya paliurus, 3-8 parts of kudzu vine root, 1-5 parts of mulberry leaf and 1-3 parts of honey-fried licorice root. All the components of the traditional Chinese medicine composition are compatible according to a certain proportion, the traditional Chinese medicine composition can tonify qi and raise yang, unblock triple jiao, dispel and strengthen evil, activate blood and dredge vessels, jointly achieve the effects of tonifying qi and nourishing, promoting qi circulation to relieve pain and tonifying kidney and dredging collaterals, can reduce the blood sugar content, protect the cardiovascular system and achieve the curative effect of preventing and treating diabetes, and has practicability and application value.

The invention discloses lactobacillus mucus with a hypoglycemic effect and an application of the lactobacillus mucus in a fermented tea beverage, the lactobacillus mucus is preserved in China Center for Type Culture Collection on December 3, 2024, and the preservation number is CCTCC NO: M20242692. The lactobacillus mucilaginosus disclosed by the invention not only has a remarkable hypoglycemic effect, but also shows a good hypoglycemic effect in a product obtained by co-fermenting the lactobacillus mucilaginosus and the Kangpu tea. The innovative combination not only enriches the nutritional value of the Kangpu tea, but also significantly improves the health benefits of the Kangpu tea, so that the Kangpu tea becomes a preferred beverage for diabetics and people pursuing healthy life, and opens up a new possibility for the functional beverage market.

The invention discloses a polypeptide with antihypertensive and hypoglycemic effects and a preparation method and application thereof. The invention discloses a polypeptide with effects of reducing blood pressure and reducing blood sugar. The amino acid sequence of the polypeptide is shown as SEQ ID NO.1, or SEQ ID NO.3, or SEQ ID NO.4, or SEQ ID NO.5, or SEQ ID NO.6, or SEQ ID NO.8, or SEQ ID NO.9, or SEQ ID NO.10. The invention further discloses a preparation method of the polypeptide. The application of the polypeptide is used for manufacturing medicines with the functions of reducing blood pressure and blood sugar. The invention also discloses a preparation method of the polypeptide with the effects of reducing blood pressure and blood sugar. The polypeptide provided by the invention not only can effectively inhibit ACE activity and reduce blood pressure, but also can regulate the blood sugar level by inhibiting DPP4 activity, and the preparation method is simple, the production cost is low, and the biological activity is high.

The technical scheme of the invention discloses black fungus protein capable of reducing blood glucose and resisting oxidation as well as a preparation method and application of the black fungus protein. The amino acid sequence of the black fungus protein is as shown in SEQ ID NO. 1. The protein which is separated and identified from the black fungus for the first time and has the effects of reducing blood glucose and resisting oxidation achieves the effect of reducing blood glucose through double inhibition of alpha-amylase and alpha-glucosidase, meanwhile, the protein has remarkable antioxidant activity, animal experiments prove that fasting blood glucose and body weight of a type II diabetes model mouse can be effectively reduced, and the protein has a good application prospect. The compound has high biological activity and safety, and can be used for developing functional products with hypoglycemic and antioxidant activity.

The invention provides a formula for regulating hyperglycemia by probiotics and a preparation method of the formula, and relates to the technical field of the probiotics, the formula comprises two formulas, the formula I comprises the probiotics, hypoglycemic pepper, raw malt, burdock, snow pear and the like, and the formula II comprises the probiotics, the hypoglycemic pepper, the raw malt, the burdock, the snow pear and the like; and the formula II consists of inonotuso bliquus polysaccharide, schizophyllum commune, chromium yeast, soybean peptide powder and lactobacillus fermentation product powder. The two formulas can be taken independently, alternately or jointly, and are used for regulating the blood sugar level of patients with hyperglycemia or type 2 diabetes mellitus. The probiotic powder contains a plurality of strains with high activity and high viable count, and plays a role in digesting and absorbing basic metabolism. The natural components in the formula have a hypoglycemic effect, and play a role in improving the secretion function of pancreas islet beta cells, improving insulin sensitivity, delaying absorption of carbohydrates, helping produce saliva and slake thirst, diluting blood sugar and other mechanisms.

Disclosed are an imidazothiazole derivative, a preparation method therefor, and an application thereof. The imidazothiazole derivative has a structure represented by formula (I): R1 and R3 are each independently selected from optionally substituted five-membered to six-membered heterocyclyl containing one to two nitrogen atoms, and R2 and R4 are each independently selected from optionally substituted aryl or heteroaryl. The imidazothiazole derivative has good MNK inhibitory activity, excellent selectivity, and an excellent in vivo hypoglycemic effect, and has a wide medicinal background.

The invention discloses a cane molasses extract with a blood sugar reducing effect as well as a preparation method and application thereof, and belongs to the field of functional foods. According to the invention, cane molasses is subjected to dissolution, centrifugation, ultrafiltration impurity removal, desalination and nanofiltration concentration, and is mixed with calcium chloride, so that the cane molasses extract with the effect of reducing blood sugar is prepared. Experimental results prove that the cane molasses extract prepared by the invention has the characteristics of low glycemic index (GI), carbohydrate digestive enzyme inhibition, high temperature resistance, long-term storage resistance and the like, can also effectively repair pancreas and liver injury and regulate intestinal flora, and has a comprehensive hypoglycemic effect. The food with low glycemic index is prepared on the basis of the high sucrose carrier for the first time, and the food has sweet taste and the function of reducing blood sugar. The invention provides a new raw material scheme for the preparation of dietary supplement food and hypoglycemic drugs for hyperglycemia people, and has prominent practical application value and wide application prospect.

The present invention provides a plant component hypoglycemic composition and its preparation method and application, belonging to the field of biomedical technology. The pharmaceutical composition is composed of the following raw materials in parts by weight: 2-5 parts of mulberry polypeptide, 5-10 parts of polygonatum and 5-10 parts of eucommia male flower, and its preparation method is to first extract mulberry polypeptide from mulberry, then crush and decoct polygonatum and eucommia male flower, and then add Lactobacillus acidophilus and Bacillus subtilis in sequence for batch fermentation, and take the fermentation supernatant and freeze-dry it and mix it with mulberry polypeptide to obtain the hypoglycemic pharmaceutical composition of the present invention. The pharmaceutical composition prepared by the present invention has a significant inhibitory effect on α-glucosidase in vitro, has a good hypoglycemic effect in vivo, has a high utilization rate of medicinal materials and has no toxic side effects, and has broad market prospects.

The invention belongs to the technical field of food biology, and particularly relates to probiotic fermented low-sugar Chinese wolfberry primary pulp or Chinese wolfberry clear juice and a preparation method thereof. According to the invention, the plant lactobacillus SV04 is used for fermenting the Chinese wolfberry primary pulp and the concentrated clear juice, and the physicochemical indexes and the change of main active components of the probiotic fermented Chinese wolfberry primary pulp and the concentrated clear juice are detected. The fermented product has the characteristics of low sugar, moderate sour and sweet taste and unique flavor, not only retains abundant nutrients and natural components of the Chinese wolfberry fruits, but also provides safer and healthier drink choices for diabetics and people with low sugar requirements through the hypoglycemic effect of the probiotics, and shows a wide application prospect of a food biotechnology in the field of nutrition and health.