Traditional Chinese medicine composition with hypoglycemic effect and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition with a hypoglycemic effect and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-23 parts of astragalus membranaceus, 12-18 parts of sambucus chinensis root, 10-15 parts of dogwood, 5-8 parts of wormwood stem, 1-5 parts of camptotheca acuminata fruit, 1-5 parts of cyclocarya paliurus, 3-8 parts of kudzu vine root, 1-5 parts of mulberry leaf and 1-3 parts of honey-fried licorice root. All the components of the traditional Chinese medicine composition are compatible according to a certain proportion, the traditional Chinese medicine composition can tonify qi and raise yang, unblock triple jiao, dispel and strengthen evil, activate blood and dredge vessels, jointly achieve the effects of tonifying qi and nourishing, promoting qi circulation to relieve pain and tonifying kidney and dredging collaterals, can reduce the blood sugar content, protect the cardiovascular system and achieve the curative effect of preventing and treating diabetes, and has practicability and application value.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition with blood sugar lowering effect and a preparation method thereof. Background Art

[0002] Diabetes is a global health problem, and the number of people with diabetes has continued to grow in recent years. Type 2 diabetes (T2DM) is a common type, which is mainly caused by the interaction of genetic and environmental factors, and manifests as varying degrees of insulin resistance, pancreatic β-cell and α-cell dysfunction, and other endocrine disorders. T2DM occurs when β-cells cannot secrete enough insulin to overcome insulin resistance.

[0003] At present, the treatment of diabetes mainly includes drug therapy, diet control and exercise therapy. In terms of drug therapy, commonly used hypoglycemic drugs include insulin, sulfonylureas, biguanides, glinides, α-glucosidase inhibitors and thiazolidinediones. However, these drugs may have some side effects, such as hypoglycemia, weight gain, gastrointestinal discomfort, etc., and some patients may develop resistance or inadaptability to certain drugs. The Chinese medicine composition, with its multi-component compatibility characteristics, helps to make up for the shortcomings of existing treatment methods and provide a more gentle and comprehensive therapeutic effect. Compared with some expensive Western medicines and insulin, the cost of Chinese medicine compositions may be lower, which helps to reduce the economic burden on patients. In addition, the preparation and use of Chinese medicine compositions are relatively simple, which is convenient for patients to use at home, and improves the convenience and operability of treatment.

[0004] According to traditional Chinese medicine theory, high blood sugar is mostly related to insufficient kidney yin and excessive fire in the lungs and stomach. Diabetes belongs to the category of "dryness", and its etiology and pathogenesis are related to factors such as yin deficiency and dryness, spleen and stomach weakness, and qi and blood deficiency. Traditional Chinese medicine has various methods to treat diabetes, including herbal medicine, acupuncture, massage, etc., aiming to achieve the purpose of treating the disease by regulating the balance of yin and yang in the human body and the function of internal organs. Although a variety of Chinese herbal medicines have been used for hypoglycemic treatment, the ingredients of different Chinese herbal medicines are complex. If they are directly mixed, they may lead to poor efficacy or even side effects due to conflicts in efficacy or improper ratios.

[0005] Therefore, developing a pure Chinese medicine composition that achieves the effect of lowering blood sugar through the mutual compatibility of various substances has important clinical significance and application value. Summary of the invention

[0006] In order to overcome the deficiencies of the prior art, the primary purpose of the present invention is to provide a Chinese medicine composition with hypoglycemic effect.

[0007] The purpose of the present invention is achieved through the following technical solutions:

[0008] A Chinese medicine composition with hypoglycemic effect comprises the following raw materials in parts by weight: 15-23 parts of astragalus, 12-18 parts of samphire roots, 10-15 parts of cornus officinalis, 5-8 parts of wormwood stems, 1-5 parts of camptotheca acuminata, 1-5 parts of cyclocarya paliurus, 3-8 parts of kudzu root, 1-5 parts of mulberry leaves and 1-3 parts of licorice root.

[0009] Further, the invention comprises the following raw materials in parts by weight: 20 parts of astragalus, 15 parts of samphire root, 12 parts of cornus officinalis, 6 parts of wormwood stem, 3 parts of camptotheca acuminata, 3 parts of cyclocarya paliurus, 5 parts of kudzu root, 3 parts of mulberry leaf, and 2 parts of licorice root.

[0010] The pharmacological and medicinal properties of the raw materials used in the present invention are analyzed as follows:

[0011] Astragalus, also known as Northeast Astragalus, Astragalus membranaceus, and Astragalus membranaceus, is a perennial herb. It has the effects of tonifying Qi and raising Yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting fluid and nourishing blood, relieving stagnation and relieving numbness, and astringing sores and promoting tissue regeneration. It is mainly used to treat all symptoms of Qi deficiency and blood deficiency, and can be used to treat Qi deficiency and fatigue, sinking of Qi in the middle, spontaneous sweating due to exterior deficiency, edema, internal heat and thirst, hemiplegia, arthralgia and numbness.

[0012] Sambucus root: sweet and flat in nature; in the field of traditional Chinese medicine, it has the effects of tonifying deficiency, removing blood stasis, clearing away heat and removing dampness. Its main functions and indications: treating hepatitis, dysentery, malaria, tuberculosis, cough, asthma, sweating, hernia, edema, metrorrhagia, and leucorrhea. "Southern Yunnan Materia Medica" records that Sambucus root has the effects of raising and lowering liver qi, promoting urination, eliminating edema, purging stomach fire and heat, treating jaundice, stopping liver qi pain, and treating hernia pain.

[0013] Cornus officinalis: sour, astringent, slightly warm; enters the liver and kidney meridians. It has the effects of strengthening the kidney and tonifying the liver, astringing the essence and consolidating collapse. Functions and indications: tonifying the liver and kidney, astringing the essence and qi, tonifying the liver and kidney, and consolidating collapse. Warming the liver and tonifying the kidney, liver deficiency cold and heat, excessive sweating, heart shaking and pulse dispersion. "Rihuazi Bencao" records that it warms the waist and knees, helps the water organs, removes all wind, drives away all qi, breaks up tumors, and treats alcohol acne.

[0014] Artemisia scoparia: spicy, sweet, cool in nature; belongs to the heart, spleen, and stomach meridians. It has the effects of strengthening the spleen and clearing heat, calming the mind, regulating qi and resolving phlegm. Functions and indications: spleen and stomach disharmony, strengthening the spleen and benefiting the stomach.

[0015] Camptotheca acuminata: cold in nature, bitter and astringent in taste; enters the spleen meridian, stomach meridian and liver meridian. It has the effect of dispersing knots and eliminating symptoms. Jiangxi's "Chinese Herbal Medicine" records that it has anti-cancer and knot-dissolving effects, and is effective for gastric cancer, rectal cancer and bladder cancer.

[0016] Cyclocarya paliurus: Spicy, slightly bitter, warm in nature. It has the effects of dispelling wind, relieving inflammation and pain, killing insects, and relieving itching. Pharmacologically, it has the effect of dilating blood vessels and improving heart blood circulation.

[0017] Pueraria root: sweet, spicy, cool, and enters the spleen and stomach meridians; it has the therapeutic effects of raising yang and stopping diarrhea, unblocking meridians and activating collaterals, and detoxifying alcohol. "Shennong's Herbal Classic" records that it can cure thirst and high fever.

[0018] Mulberry leaf: bitter, sweet, cold in nature. Enters the lung and liver meridians. It has the effects of dispersing wind-heat, clearing the lungs and moistening dryness, calming the liver and improving eyesight, cooling blood and stopping bleeding. According to the "Compendium of Materia Medica", it is "bitter, sweet and cool. It nourishes dryness and cools blood, stops bleeding and removes wind, and clears the heat of the Shaoyang meridian."

[0019] Roasted Licorice: sweet, neutral; enters the spleen, stomach and lung meridians. It is mainly used to treat spleen and stomach weakness, poor appetite, abdominal pain and loose stools, fatigue and fever, pulmonary tuberculosis and cough, palpitations, and epilepsy; when used raw, it can treat sore throat, peptic ulcer, carbuncle, and ulcer, and detoxify drugs and food poisoning. The "Ben Jing" records that it can cure cold and heat evil spirits in the five internal organs and six organs, strengthen tendons and bones, grow muscles, double strength, treat wounds and swellings, and detoxify.

[0020] Another object of the present invention is to provide a method for preparing the above-mentioned Chinese medicine composition with hypoglycemic effect.

[0021] The purpose of the present invention is achieved through the following technical solutions:

[0022] The preparation method of the above-mentioned Chinese medicine composition with hypoglycemic effect comprises the following steps:

[0023] Weigh each raw material drug according to the above weight portion, grind and sieve, mix evenly, soak and decoct in water, filter and collect the filtrate after decoction; soak the filter residue in water again, decoct and filter; combine the two filtrates, concentrate to an extract with a relative density of 1.0-1.1, and prepare the extract and pharmaceutically acceptable excipients into corresponding dosage forms.

[0024] Furthermore, the mass ratio of the total mass of each raw material drug to water is 1:(6-10).

[0025] Furthermore, the soaking time for both times is 1 to 2 hours; the decoction temperature for both times is 90 to 100° C., and the decoction time is 60 to 120 minutes.

[0026] Furthermore, the mesh size of the sieving screen is 50 to 100 meshes.

[0027] Furthermore, the dosage form is an oral dosage form.

[0028] Furthermore, the oral dosage form is any one of oral liquid, tablet, pill, granule, and capsule.

[0029] The present invention has the following effects compared with the prior art:

[0030] 1. The present invention provides a Chinese medicine composition with hypoglycemic effect, wherein astragalus, sage root, and cornus officinalis are used as the main medicines for invigorating qi and raising yang, tonifying deficiency and removing blood stasis, and strengthening the kidney and liver; wormwood stems are used for invigorating spleen and clearing heat, and camptothecoides acuminata is used for dispersing knots and eliminating symptoms; the three ingredients of Cyclocarya paliurus are used for lowering blood pressure and strengthening the heart, Pueraria root is used for promoting meridians and tonifying collaterals, and mulberry leaf is used for clearing heat and cooling blood; and licorice is used to reconcile the various medicines, so it is used as the messenger. The ingredients are compatible with each other, invigorating qi and raising yang, unblocking the three energizers, removing and supporting evil, promoting blood circulation and unblocking meridians, and playing the effects of invigorating qi and nourishing, promoting qi and relieving pain, and tonifying the kidney and unblocking collaterals, which can reduce blood sugar content, protect the cardiovascular system, and achieve the efficacy of preventing and treating diabetes, and have practicality and application value.

[0031] 2. The Chinese medicine composition of the present invention follows the principle of monarch, minister, assistant and envoy, has a reasonable compatibility relationship, conforms to the theory of traditional Chinese medicine, and has a high safety, which can provide a new therapeutic idea for the prevention and treatment of diabetes. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 This is a graph showing the effect of the Chinese medicine composition decoction of the present invention on the serum liver function indexes of rats;

[0033] Figure 2 This is a graph showing the effect of the Chinese medicine composition decoction of the present invention on serum renal function indexes in rats. DETAILED DESCRIPTION

[0034] The present invention will be described in further detail below in conjunction with the examples, but the embodiments of the present invention are not limited thereto. Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the art. The test methods for which specific experimental conditions are not specified in the following examples are usually carried out according to conventional experimental conditions or according to the experimental conditions recommended by the manufacturer. Unless otherwise specified, the reagents and raw materials used in the present invention can be obtained commercially.

[0035] Example 1

[0036] A Chinese medicine composition with hypoglycemic effect, wherein the raw materials are composed in parts by weight: 20 parts of astragalus, 15 parts of samphire root, 12 parts of cornus officinalis, 6 parts of wormwood stem, 3 parts of camptotheca acuminata, 3 parts of cyclocarya paliurus, 5 parts of kudzu root, 3 parts of mulberry leaf and 2 parts of roasted liquorice.

[0037] The preparation method of the above-mentioned Chinese medicine composition with hypoglycemic effect is as follows:

[0038] Weigh astragalus, samphire root, cornus officinalis, wormwood stem, camptotheca acuminata, cyclocarya paliurus, kudzu root, mulberry leaf, and licorice root, crush each weighed raw material respectively and pass through an 80-mesh sieve, mix evenly, add 8 times the amount of water, and soak for 1.5 hours; decoct the mixed solution after soaking at 95° C. for 90 minutes, filter with gauze, collect the filtrate, and retain the filter residue; add 8 times the amount of water to the filter residue again, soak for 1.5 hours, decoct at 95° C. for 90 minutes, and filter to obtain a filtrate; combine the two filtrates and concentrate at 65° C., and concentrate the filtrate to an extract with a relative density of 1.0, so as to obtain the traditional Chinese medicine composition;

[0039] This embodiment also includes the step of preparing the Chinese medicine composition into capsules: drying the extract and then crushing it, and filling it into capsules as capsule powder to prepare capsules.

[0040] Example 2

[0041] A Chinese medicine composition with hypoglycemic effect, wherein the raw materials are composed in weight parts as follows: 15 parts of astragalus, 12 parts of samphire root, 10 parts of cornus officinalis, 5 parts of wormwood stem, 1 part of camptotheca acuminata, 1 part of Cyclocarya paliurus, 3 parts of kudzu root, 1 part of mulberry leaf and 1 part of roasted liquorice.

[0042] The preparation method of the above-mentioned Chinese medicine composition with hypoglycemic effect is as follows:

[0043] Weigh astragalus, samphire root, cornus officinalis, wormwood stem, camptotheca acuminata, cyclocarya paliurus, kudzu root, mulberry leaf, and licorice root, crush each weighed raw material respectively and pass through a 50-mesh sieve, mix evenly, add 6 times the amount of water, and soak for 1 hour; decoct the mixed solution after soaking at 90° C. for 120 minutes, filter with gauze, collect the filtrate, and retain the filter residue; add 6 times the amount of water to the filter residue again, soak for 1 hour, decoct at 90° C. for 120 minutes, and filter to obtain a filtrate; combine the two filtrates and concentrate at 65° C., and concentrate the filtrate to an extract with a relative density of 1.0, so as to obtain the traditional Chinese medicine composition;

[0044] This embodiment also includes the step of preparing the Chinese medicine composition into granules: adding xylitol to the extract to prepare granules by conventional methods.

[0045] Example 3

[0046] A Chinese medicine composition with hypoglycemic effect, wherein the raw materials are composed in weight parts as follows: 23 parts of astragalus, 18 parts of samphire root, 15 parts of cornus officinalis, 8 parts of wormwood stem, 5 parts of camptotheca acuminata, 5 parts of cyclocarya paliurus, 8 parts of kudzu root, 5 parts of mulberry leaf and 3 parts of roasted liquorice.

[0047] The preparation method of the above-mentioned Chinese medicine composition with hypoglycemic effect is as follows:

[0048] Weigh astragalus, samphire root, cornus officinalis, wormwood stem, camptotheca acuminata, cyclocarya paliurus, kudzu root, mulberry leaf, and licorice root, crush each weighed raw material respectively and pass through a 100-mesh sieve, mix evenly, add 10 times the amount of water, and soak for 2 hours; decoct the mixed solution after soaking at 100° C. for 60 minutes, filter with gauze, collect the filtrate, and retain the filter residue; add 10 times the amount of water to the filter residue again, soak for 2 hours, decoct at 100° C. for 60 minutes, and filter to obtain a filtrate; combine the two filtrates and concentrate at 65° C., and concentrate the filtrate to an extract with a relative density of 1.0, thereby obtaining the traditional Chinese medicine composition;

[0049] This embodiment also includes the step of preparing the Chinese medicine composition into an oral liquid: adding xylitol to the extract to prepare the oral liquid in a conventional manner.

[0050] Comparative Example 1

[0051] This comparative example provides a Chinese medicine composition with hypoglycemic effect, which is different from Example 1 in that the saussurea root is omitted, and the rest is consistent with Example 1.

[0052] Comparative Example 2

[0053] This comparative example provides a Chinese medicine composition with hypoglycemic effect, which is different from Example 1 in that the amount of Sambucus root is adjusted to 25 parts, and the rest is consistent with Example 1.

[0054] Comparative Example 3

[0055] This comparative example provides a Chinese medicine composition with hypoglycemic effect, which is different from Example 1 in that the dosage of Sambucus sabdariffa root is adjusted to 5 parts, and the other parts are consistent with Example 1.

[0056] Comparative Example 4

[0057] This comparative example provides a Chinese medicine composition with hypoglycemic effect, which is different from Example 1 in that the Artemisia scoparia stem is omitted, and the rest is consistent with Example 1.

[0058] Comparative Example 5

[0059] This comparative example provides a Chinese medicine composition with hypoglycemic effect, which is different from Example 1 in that the fruit of Camptotheca acuminata is omitted, and the rest is consistent with Example 1.

[0060] The following are the effect tests of Examples 1 to 3 and Comparative Examples 1 to 5.

[0061] Test Example 1

[0062] Safety experiment: 8-10 weeks old, SPF grade SD rats, half male and half female, weighing 240-280g, were selected, and the breeding environment was a clean laboratory, the temperature was 25°C, the relative humidity was maintained at 55%, the bedding was changed for the rats every day, and a cycle of 12 hours of light and 12 hours of darkness was set. The rats were adaptively raised for 7 days, and they were free to eat and drink water every day. Then the rats were randomly divided into the high-dose group of Example 1: 8g (crude drug) / kg, the low-dose group of Example 1: 2g (crude drug) / kg, the medium-dose group of Example 1: 4g (crude drug) / kg, and the blank control group, with 6 rats in each group. The high, low and medium-dose groups of Example 1 were continuously gavaged with the corresponding dose of the Chinese medicine composition prepared in Example 1 for 60 days, and the blank control group was given an equal amount of physiological saline. The rats were weighed every other day, and then blood samples were collected by removing the eyeballs for routine blood analysis. The collected blood was centrifuged at 4000 rpm for 10 min, and the liver function indicators alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and renal function indicators creatinine (CR) and blood urea nitrogen (BUN) in the supernatant were tested using an automatic biochemical analyzer. The test results are as follows Figure 1 and Figure 2 shown.

[0063] Compared with the blank control group, after the rats were gavaged with the Chinese medicine composition of the present invention, their behavior, defecation, drinking water and eating, and mental state were good, and no death or adverse phenomena occurred. Figure 1 and Figure 2 The test results show that, compared with the blank control group, after being fed with the low, medium and high doses of the Chinese medicine composition of Example 1, no obvious abnormalities were found in the liver function indexes and kidney function indexes in the serum of the rats, indicating that the Chinese medicine composition of the present invention will not produce obvious toxic and side effects on animals and can be used for subsequent experimental research.

[0064] Test Example 2

[0065] 1. Experimental Animal Grouping

[0066] 8-10 week old, SPF grade SD rats, half male and half female, weighing 240-280g, were selected, and the breeding environment was a clean laboratory, the temperature was 25°C, the relative humidity was maintained at 55%, the bedding was changed for the rats every day, a cycle of 12 hours of light and 12 hours of darkness was set, and the rats were adaptively raised for 7 days, and they were free to eat and drink water every day. Then the rats were randomly divided into the high-dose group of Example 1, the medium-dose group of Example 1, the low-dose group of Example 1, the comparative example 1 group, the comparative example 2 group, the comparative example 3 group, the comparative example 4 group, the comparative example 5 group, the model group, the blank control group, the positive control group, and 10 rats in each group.

[0067] 2. Construction of rat diabetes model

[0068] STZ was dissolved in sodium citrate buffer at pH 4.0 to prepare a 1.0% STZ solution for use. The rats in the blank control group were not treated (given ordinary feed), and the other rats were injected with STZ solution at a dose of 20 mg / kg into the rat tail vein. After 3 days of injection, they were fed with a high-fat diet for 6 weeks; they were fasted but not watered for 12 hours, and blood was collected from the rat tail vein to detect the blood sugar level of the rats. The phenomena of mental depression and obesity were observed in the rats, and the fasting blood sugar level was higher than 11.1 mmol / L, indicating that the rat diabetes model was successfully established.

[0069] 3. Drug administration

[0070] After the model was successfully established, each group of rats was given medication as follows:

[0071] Example 1 low-dose group: rats were intragastrically administered 2 g / kg of the Chinese medicine composition prepared in Example 1 every day;

[0072] Medium dose group in Example 2: rats were intragastrically administered 4 g / kg of the Chinese medicine composition prepared in Example 1 every day;

[0073] Example 3 High-dose group: rats were intragastrically administered 8 g / kg of the Chinese medicine composition prepared in Example 1 every day;

[0074] Comparative Example 1 group: rats were intragastrically administered 8 g / kg of the Chinese medicine composition prepared in Comparative Example 1 every day;

[0075] Comparative Example 2 group: rats were intragastrically administered 8 g / kg of the Chinese medicine composition prepared in Comparative Example 2 every day;

[0076] Comparative Example 3 group: rats were intragastrically administered 8 g / kg of the Chinese medicine composition prepared in Comparative Example 3 every day;

[0077] Comparative Example 4 group: rats were intragastrically administered 8 g / kg of the Chinese medicine composition prepared in Comparative Example 4 every day;

[0078] Comparative Example 5 group: rats were intragastrically administered 8 g / kg of the Chinese medicine composition prepared in Comparative Example 5 every day;

[0079] Blank control group: an equal volume of normal saline was given by gavage every day;

[0080] Positive control group: metformin (dose 0.25 g / kg) was administered by gavage;

[0081] Model group: an equal volume of normal saline was administered by gavage;

[0082] The drug was administered by intragastric gavage for 28 consecutive days. The changes in blood sugar and body weight of the rats were measured before administration (i.e., the first day after successful modeling) and 28 days after administration. The test results are recorded in Tables 1 and 2.

[0083] Table 1 Blood glucose levels in rats before and after administration

[0084]

[0085]

[0086] From the test results in Table 1, it can be seen that compared with the normal control group, the blood glucose levels of the rats in the model group increased significantly, indicating that the rat diabetes model was successfully established. Compared with the model group, on the 28th day after administration, the blood glucose levels of the rats in the low, medium, high doses of Example 1 and the positive control group all decreased significantly, and after being treated with the Chinese medicine composition of the high dose group of Example 1 of the present invention, the blood glucose level decreased to a level similar to that of the positive administration group, indicating that the Chinese medicine composition of the present invention has a good hypoglycemic effect.

[0087] After the main medicine Sambucus root was omitted in Comparative Example 1, the blood sugar reduction level was significantly reduced, indicating that Sambucus root can replenish qi and raise yang in the Chinese medicine composition, and plays an important role in reducing blood sugar levels. After adjusting the dosage of Sambucus root in Comparative Example 2 and 3, the blood sugar reduction level was not as good as the low, medium and high dose groups in Example 1, indicating that the dosage of Sambucus root in the prescription needs to be controlled within a reasonable range. Comparative Example 4 omitted Artemisia stalks, and Comparative Example 5 omitted Camptotheca acuminata fruit. Although the blood sugar levels of rats were reduced, their therapeutic effects were far less than those of the high dose group in Example 1. It shows that Artemisia stalks and Camptotheca acuminata fruit can be compatible with each component in Chinese medicine, work together, and reduce blood sugar levels.

[0088] Table 2 Body weight changes of rats before and after administration

[0089]

[0090]

[0091] It can be seen from the experimental data in Table 2 that, compared with the model group, the body weight of rats in the low, medium and high doses of Example 1 of the present invention was significantly reduced, indicating that the above treatment can reduce the body weight of diabetic model rats. Among them, after the dosage of Elderberry was adjusted in Comparative Examples 1 to 3, the degree of weight loss of rats was reduced. Although the body weight of rats in Comparative Examples 4 and 5 was reduced, it was far less obvious than the effect of the high dose group in Example 1.

[0092] The above-mentioned embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and substitutions made by technicians in this field on the basis of the present invention shall fall within the scope of protection required by the present invention.

Claims

1. A Chinese medicine composition with hypoglycemic effect, characterized in that: The invention comprises the following raw materials in parts by weight: 15-23 parts of astragalus, 12-18 parts of samphire root, 10-15 parts of cornus officinalis, 5-8 parts of wormwood stem, 1-5 parts of camptotheca acuminata, 1-5 parts of cyclocarya paliurus, 3-8 parts of kudzu root, 1-5 parts of mulberry leaf and 1-3 parts of licorice root.

2. The Chinese medicine composition with hypoglycemic effect according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 20 parts of astragalus, 15 parts of samphire root, 12 parts of cornus officinalis, 6 parts of wormwood stem, 3 parts of camptotheca acuminata fruit, 3 parts of cyclocarya paliurus, 5 parts of kudzu root, 3 parts of mulberry leaf and 2 parts of roasted licorice root.

3. The method for preparing the Chinese medicine composition with hypoglycemic effect as claimed in claim 1 or 2, characterized in that: The following steps are involved: Weigh each raw material drug according to the weight portion, grind and sieve, mix evenly, soak in water, decoct, filter and collect the filtrate after decoction; soak the filter residue in water again, decoct and filter; combine the two filtrates, concentrate to an extract with a relative density of 1.0-1.1, and prepare the extract and pharmaceutically acceptable excipients into corresponding dosage forms.

4. The method for preparing the Chinese medicine composition with hypoglycemic effect according to claim 3, characterized in that: The mass ratio of the total mass of each raw material drug to water is 1:(6-10).

5. The method for preparing the Chinese medicine composition with hypoglycemic effect according to claim 3, characterized in that: The soaking time for both times is 1 to 2 hours; the decoction temperature for both times is 90 to 100°C and the decoction time is 60 to 120 minutes.

6. The method for preparing the Chinese medicine composition with hypoglycemic effect according to claim 3, characterized in that: The mesh number of the sieving screen is 50 to 100 meshes.

7. The method for preparing the Chinese medicine composition with hypoglycemic effect according to claim 3, characterized in that: The dosage form is an oral dosage form.

8. The method for preparing the Chinese medicine composition with hypoglycemic effect according to claim 7, characterized in that: The oral dosage form is any one of oral liquid, tablet, pill, granule, and capsule.

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