55 results about "Pediococcus acidilactici" patented technology

The invention discloses pediococcus acidilactici and application thereof in preparation of a medicine for preventing or treating diarrhea of yak calves, and belongs to the technical field of microorganisms. The pediococcus acidilactici is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M20252012, and the preservation date is September 12, 2025. The strain has remarkable bacteriostatic activity on yak-derived multi-drug-resistant escherichia coli (the accession number of NCBI is PP859186). After the probiotic preparation is orally taken, the yak calf diarrhea induced by escherichia coli can be effectively relieved, the diarrhea rate and the inflammatory factor level are remarkably reduced, the oxidation resistance is improved, the flora structures of intestinal bacteria and fungi are adjusted, and the micro-ecological balance is restored. The invention provides a safe, green and efficient alternative antibody product which is suitable for the plateau yak breeding industry.

The application provides a pediococcus acidilactici M4 for low-moisture fermented feed and an application thereof, and belongs to the field of microbial application and feed technology. The application uses the pediococcus acidilactici M4 to prepare fermented total mixed ration. The bacteria have the characteristics of high osmosis and fast acid production, and can reduce the pH value of the fermentation system in a short time; have strong broad-spectrum bacteriostatic effect on escherichia coli, chicken white dysentery salmonella and staphylococcus aureus; and perfectly adapt to the fermentation of low-moisture total mixed ration. The strain is used as the fermentation strain of low-moisture total mixed ration, can significantly reduce the content of acid detergent fiber and neutral detergent fiber, improve the crude protein level, and then improve the digestibility of the daily ration, increase the content of probiotics such as lactic acid bacteria and yeast in the daily ration, reduce the content of pathogenic bacteria such as escherichia coli in the daily ration, and also can improve the content of volatile fatty acid in the daily ration, improve the quality of the daily ration, and improve the feeding value of the daily ration.

The invention relates to pediococcus acidilactici b1274 and application thereof, and belongs to the technical field of beneficial bacterium application. The pediococcus acidilactici b1274 is preserved in the China Center for Type Culture Collection on September 24, 2025, the preservation number is CCTCC M 20252094, and the pediococcus acidilactici b1274 is obtained by separation and purification from distiller's yeast. The pediococcus acidilactici can be used for preparing microbial enhanced distiller's yeast, is applied to brewing of fen-flavor liquor, and can improve the content of ethyl acetate, ethyl lactate and total acid in the liquor and reduce the content of acetaldehyde at the same time. Compared with a production control group, the content of ethyl acetate is increased by 50.0%, the content of ethyl lactate is increased by 8.1%, the total acid is increased by 46.4%, the acetaldehyde is reduced by 48.4%, the brewed white spirit shows the style of faint scent, purity, mellowness, fullness, softness, sweetness, freshness, long aftertaste and mellow and prominent acid ester taste, and a safe and reliable functional strain and a technical scheme are provided for improving the quality of the fen-flavor white spirit.

The invention relates to the technical field of microbial food fermentation, and particularly discloses pediococcus acidilactici RM1, a separation method and application, and the pediococcus acidilactici RM1 is characterized in that the preservation number of the pediococcus acidilactici RM1 is GDMCC NO.66765; the preservation unit of the pediococcus acidilactici RM1 is Guangdong Microbial Culture Collection Center; the preservation name of the pediococcus acidilactici RM1 is pediococcus acidilactici RM1, and the preservation name of the pediococcus acidilactici RM1 is pediococcus acidilactici RM1. The preservation time of the pediococcus acidilactici RM1 is July 28, 2025. The method has the characteristics of bright red color, difficulty in deterioration during storage and ideal quality and flavor.

Probiotic compositions comprising Bacillus subtilis, Bacillus licheniformis and Pediococcus acidilactici in amounts effective for promoting digestive health, decreasing endotoxemia, decreasing diarrhea, decreasing vomiting and increasing the digestibility of foodstuffs in dogs.

The application discloses a method for extracting pectin from coffee mucilage by using microorganisms, and belongs to the field of microbial fermentation. The method comprises the following steps: inoculating Pediococcus acidilactici and Pichia kluyveri compound bacterial liquid with a compound ratio of 2:1 into coffee fresh beans in a fermentation tank, inoculating the bacterial liquid at a concentration of 7logCFU / mL, fermenting at a temperature of 32 DEG C, and fermenting for 36 hours. After the pectin layer is gradually separated from the coffee beans, the pectin in the mucilage is extracted and used for preparing thickening agents, emulsifying agents and gel agents in food.

This invention discloses *Pediococcus lactis* TC-4, which simultaneously degrades nucleosides, purines, and uric acid, and its applications. *Pediococcus lactis* ( Pediococcus acidilactici This invention relates to *Pediococcus lactis* TC-4, with accession number GDMCC No: 67936. *Pediococcus lactis* TC-4 of this invention can efficiently degrade three nucleosides (guanosine, adenosine, and inosine), three purines (guanine, xanthine, and hypoxanthine), and uric acid in vitro. *Pediococcus lactis* TC-4 of this invention can effectively reduce serum uric acid levels in broiler chickens, alleviating and treating hyperuricemia. Compared with traditional chemical drugs for treating hyperuricemia and / or gout, this invention has no toxic side effects on the ecological environment, no residue risk, and is green and safe. This invention has been confirmed at multiple levels, including genetic and animal studies, to have no potential harm to humans, demonstrating its advantages of safety and high efficiency.

The present application relates to a Pediococcus acidilactici capable of reducing the activation of hippocampal microglia cells and its application, belonging to the technical field of microorganisms. The Pediococcus acidilactici described in the present application is Pediococcus acidilactici CCFM1344, which was preserved in the Guangdong Microbial Culture Collection Center on September 12, 2023, with the preservation number GDMCC NO.63800. The preservation address is Building 59, 5th Floor, Guangdong Microbial Institute, 100 Middle Martyrs Road, Guangzhou. The Pediococcus acidilactici described in the present application can inhibit the over-activation of microglia cells caused by chronic stress, reduce the concentration of pro-inflammatory factors in the hippocampus of the brain, thereby relieving the activation of microglia cells in the hippocampus of the brain caused by chronic stress, and has excellent application prospects.

The invention relates to the technical field of probiotics, in particular to intestinal tract source pediococcus acidilactici of Yanqu county in Tibet and fat reducing application thereof. The pediococcus acidilactici disclosed by the invention is preserved in the China General Microbiological Culture Collection Center on April 29, 2025, and the preservation number is CGMCC NO.34406; the strain has the characteristics of acid resistance, cholate resistance and stress resistance, and has high survival rate and planting efficiency; the strain is free of hemolysis, free of toxic factors and high in safety; the strain can secrete short-chain fatty acid and antibacterial peptide, inhibit pathogenic bacteria and promote intestinal barrier repair; short-chain fatty acid generated by metabolism of most of carbon water by the strain can be directly absorbed by intestinal epithelial cells, and can be used as an energy substance to replace partial glucose demand, so that the metabolism energy consumption is reduced, the energy conversion rate of feed is improved, the feed conversion is promoted, and the effects of reducing fat and weight and improving the non-alcoholic fatty liver disease are achieved.

This application belongs to the field of microbial technology, and mainly relates to a strain of *Pediococcus lactis* BPA03 and its applications. *Pediococcus lactis* BPA03 is classified and named *Pediococcus lactis*. Pediococcus acidilactici This *Pediococcus lactis* strain BPA03 was deposited on September 28, 2025, at the China General Microbiological Culture Collection Center (CGMCC), located at No. 3, Courtyard 1, Beichen West Road, Chaoyang District, Beijing, with accession number CGMCC No. 36109. It inhibits skin melanin deposition and improves UV photoaging, suppresses the gene expression levels of immune factors such as IL-1β, IL-6, IL-8, and TNF-α, improves the activities of superoxide dismutase, catalase, and glutathione peroxidase, inhibits vinorelbine-induced neutropenia, and improves the inhibition of immune factor expression induced by vinorelbine, thus exhibiting comprehensive anti-aging effects.

The invention provides pediococcus acidilactici with functions of improving emotion and intestinal health and application of the pediococcus acidilactici. The pediococcus acidilactici A25-4 is preserved in Guangdong Microbial Culture Collection Center on May 23, 2025, and the preservation number of the pediococcus acidilactici A25-4 is GDMCC NO: 66384. The pediococcus acidilactici A25-4 has better cholate resistance and artificial gastrointestinal fluid resistance and can produce indole lactic acid ILA at high yield, and the optimal carbon source is fructo-oligosaccharide and galactooligosaccharide. The pediococcus acidilactici A25-4 in-vivo intervention can significantly improve the symptoms of an irritable bowel syndrome model mouse, specifically, the anxiety mood of a tested object is significantly improved; the viscera hypersensitivity of a tested object is obviously relieved; excessive activation of mast cells of a tested object is obviously inhibited; the ILA level in a tested object is obviously improved.

The present application relates to the technical field of microorganism, and particularly relates to a streptococcus lactis with a cat dandruff treatment function and application thereof. Pediococcus acidilactici The streptococcus lactis is preserved in the Guangdong Provincial Microbial Culture Collection Center on September 26, 2025, and the preservation number is GDMCC No: 67035. The streptococcus lactis and the inactivated bacteria solution provided in the present application have good inhibitory effects on trichophyton mentagrophytes and mycosporum gypseum. The streptococcus lactis provided in the present application can also be used for treating cat dandruff, and compared with ketoconazole cream, the streptococcus lactis has faster effect and shorter treatment cycle.

The application discloses a Pediococcus acidilactici for improving color and flavor of low-salt solid-state soy sauce and belongs to the technical field of bioengineering. The application obtains a Pediococcus acidilactici WT1 which can grow well under higher temperature and certain salinity by being separated and screened from soy sauce mash. The P.acidilactici WT1 is strengthened to carry out low-salt solid-state soy sauce fermentation, so that the amino acid nitrogen of the soy sauce is increased by 9.43%, the contents of succinic acid and tartaric acid in the soy sauce are respectively increased by 71.87% and 5.43 times, the contents of umami and sweet amino acids are respectively increased by 35.16% and 13.44%, the total amount of volatile flavor substances is increased by 19.95%, and the color rate is increased by 21.36%. By strengthening the P.acidilactici WT1, the contents of main flavor substances, i.e., guaiacol and phenol in the soy sauce are respectively increased by 35.49% and 50.64%, and the contents of benzyl alcohol and isoamyl alcohol are respectively increased by 16.83% and 21.86%. Therefore, strengthening the P.acidilactici WT1 in the low-salt solid-state soy sauce fermentation process has important significance for improving the quality and flavor of the low-salt solid-state soy sauce.

The invention provides a probiotic composition for improving the production performance of quails as well as a preparation method and application of the probiotic composition, and relates to the technical field of microecologics. The probiotic composition for improving the production performance of the quails is prepared from lactobacillus casei C-9, lactobacillus plantarum HM-05 and pediococcus acidilactici PA-19. The preservation number of the lactobacillus casei C-9 is CGMCC (China General Microbiological Culture Collection Center) No.6734, the preservation number of the lactobacillus plantarum HM-05 is CGMCC No.6739, and the preservation number of the pediococcus acidilactici PA-19 is CGMCC No.19881; the viable bacteria ratio of the lactobacillus casei C-9 to the lactobacillus plantarum HM-05 to the pediococcus acidilactici PA-19 is (1-3): (1-8): (1-3); the probiotic composition has excellent gastrointestinal mucosa colonization ability, and can inhibit the growth of common pathogenic bacteria, improve the intestinal microecological balance and improve the body health level, thereby effectively improving the production performance of egg quails and egg breeding quails and promoting healthy, green and efficient breeding of the egg quail breeding industry.

The invention provides a method for degrading urea and EC in Baijiu by bacillus-lactic acid bacteria compound bacteria. The compound bacteria comprise Pediococcus aryabhattai DQ10 and Pediococcus acidilactici DQ42, and the preservation numbers of the Pediococcus acidilactici DQ42 and the Pediococcus acidilactici DQ42 are respectively CGMCC (China General Microbiological Culture Collection Center) NO.36245 and CGMCC NO.36386. The invention further discloses a preparation method of the compound bacteria. The two strains are separated from high-temperature Daqu of Baijiu, can tolerate high temperature, acid and ethanol, and can grow under stress conditions in the fermentation process of the Baijiu, particularly, urea and ethyl carbamate (EC) in the fermentation process of liquor products (especially the Baijiu) can be effectively degraded by singly or combining the two strains (especially the complex microbial inoculants), the content of the urea and the EC can be remarkably reduced, and the yield of the liquor products is improved. The safety of liquor products can be improved, and a novel and safe microbial material is provided for the liquor brewing industry.

This invention provides *Pediococcus lactis* SHI03 and its application in alleviating insulin resistance and type 2 diabetes, belonging to the field of microbial technology. This invention provides *Pediococcus lactis* SHI03, with accession number CCTCC No: M 20242686, and confirms that this strain possesses in vitro α-glucosidase inhibitory activity, exhibiting excellent probiotic and hypoglycemic effects. This invention further provides microbial products containing *Pediococcus lactis* SHI03, including *Pediococcus lactis* SHI03 fermentation broth, *Pediococcus lactis* SHI03 fermentation supernatant, and *Pediococcus lactis* SHI03 cells, and their applications in alleviating high-fat diet-induced insulin resistance and reducing fasting blood glucose in type 2 diabetic mice.

The invention discloses a fermented feed additive for replacing soybean meal as well as a preparation method and application of the fermented feed additive. The fermented feed additive disclosed by the invention is prepared by performing acid protease enzymolysis on a mixed fermentation raw material and fermenting the mixed fermentation raw material with a complex microbial inoculant, wherein the mixed fermentation raw materials comprise the following components in parts by weight: 40-80 parts of corn protein powder, 30-60 parts of corn steep liquor, 7-12 parts of corn germ meal, 4-15 parts of molasses and 2-5 parts of extruded soybeans; the complex microbial inoculant is composed of pediococcus acidilactici, candida utilis and bacillus subtilis according to the viable count ratio of (1-3): (1-3): (0.1-1). The fermented feed additive can effectively replace soybean meal in animal daily ration, the utilization rate of nutrients by animals is increased, the health level of the animals is improved, and the production performance of the animals is improved.

The invention relates to pediococcus acidilactici PA153 for inhibiting intestinal pathogens of laying hens, a metagen and application of the pediococcus acidilactici PA153 and the metagen, the preservation number of the pediococcus acidilactici PA153 is CCTCC NO: M 2023230, and a preparation method of the metagen comprises the steps that 1, a fermentation medium is inoculated with a pediococcus acidilactici PA153 strain for fermentation culture, and fermentation liquor is obtained; step 2, centrifuging the fermentation liquor, and collecting bacterial sludge; step 3, adding a protective solution into the bacterial sludge, and uniformly mixing to obtain an emulsion; and step 4, spraying the emulsified liquid as slurry into a fluidized bed of a boiling granulation dryer, adding maltodextrin into the fluidized bed of the boiling granulation dryer, granulating the emulsified liquid and the maltodextrin together, and drying to obtain the metabiotics. The feed can inhibit enteropathogenic bacteria of laying hens, improve intestinal health of the laying hens and improve the production performance of the laying hens, and is good in safety, high in stability, high in environmental adaptability, convenient to transport and store and free of drug resistance.

The invention discloses a cat lactic acid bacteria strain and application thereof, and belongs to the field of microbial preparations. According to the invention, a cat-source probiotic strain, namely pediococcus acidilactici G91, with excellent characters is screened from healthy kittens. The strain not only is subjected to acid-resistant and cholate-resistant severe digestive tract environment simulation screening, but also shows excellent self-aggregation capability, surface hydrophobicity, cell adhesion capability, antibacterial capability and other core probiotic characteristics. Further biological identification and hemolytic property and drug sensitivity determination prove that the strain is safe pediococcus acidilactici which is non-hemolytic and sensitive to antibiotics, G91 can promote growth and development of seedlings, improve intestinal barriers and functions, regulate intestinal flora and immune systems and effectively resist salmonella constant value and infection, and the strain has excellent probiotic performance and can be used for preparing the feed additive. The strain is an ideal strain resource for developing a micro-ecological preparation for cats, and provides a safe and efficient novel micro-ecological product and a technical scheme for healthy breeding and disease prevention of pet cats.

The application belongs to the field of microorganisms, and provides a composite strain, a bacterial agent and application of the composite strain in preparation of fermented east perilla tea. The composite strain comprises Lactiplantibacillus plantarum 2HDS3-La5 with a preservation number of CGMCC NO.34339, Pediococcus acidilactici 2HDS3-SM6 with a preservation number of CGMCC NO.34337, and Weizmannia coagulans N2-La1 with a preservation number of CGMCC NO.34338. The application also provides application of the composite strain or the bacterial agent containing the composite strain in preparation of fermented east perilla tea. The composite strain is applied in preparation of fermented east perilla tea, significantly improves the content of substances with anti-inflammatory, antioxidant and immune-regulating effects in east perilla tea, and the improvement multiple is significant. The prepared fermented east perilla tea can significantly improve cell viability.

The invention relates to the technical field of functional foods, and particularly discloses an intestine-moistening and excretion-promoting composition, a compound probiotic preparation and a preparation method of the compound probiotic preparation. The invention provides a composition capable of moistening intestines and promoting excretion. The composition is prepared from the following raw materials in parts by weight: 75 to 150 parts of erythritol, 45 to 90 parts of inulin, 45 to 90 parts of lactitol, 25 to 50 parts of fructus cannabis, 12 to 25 parts of semen raphani, 15 to 30 parts of fructus crataegi, 27 to 55 parts of fructus lycii, 27 to 54 parts of fructo-oligosaccharide, 12 to 25 parts of resistant dextrin and 15 to 33 parts of probiotics. The probiotics are selected from one or more of lactobacillus rhamnosus, pediococcus acidilactici, bifidobacterium animalis, lactobacillus plantarum and lactobacillus reuteri; the invention further provides a compound probiotic preparation prepared from the intestine moistening and excretion promoting composition. The composite probiotic agent provided by the invention can regulate the balance of intestinal flora and promote gastrointestinal motility, and has very good intestine moistening and excretion promoting effects.

The application relates to a production method and application of combined fermentation of bupleurum and lonicera japonica residues by bacillus velezensis and pediococcus acidilactici, and belongs to the technical field of biotechnology. The bupleurum and lonicera japonica residues are treated by adopting a process of enzymolysis first and then fermentation, wherein the composite enzyme comprises cellulase, beta-glucanase, xylanase, beta-mannanase and phytase; and the fermentation bacteria comprise bacillus velezensis and pediococcus acidilactici. The fermented bupleurum and lonicera japonica residues provided by the application have a high release amount of active ingredients (chlorogenic acid, forsythoside and baicalin), and the addition ratio in broiler chickens is 2.0%-4.0%. The application effect includes improving growth performance, improving the levels of anti-inflammatory factor IL-10 and serum immunoglobulin IgM of the body, improving the muscle quality and flavor characteristics of the breast muscle, and improving the contents of inosinic acid, intramuscular protein, flavor amino acid and total amino acid. The product can not only improve the yield and quality of livestock products, but also relieve the pressure on the environment caused by solid waste residues, and has a good market prospect.

This invention discloses bacterial strains, compound microbial agents, and a method for rapidly preparing Luocheng rice noodles, relating to the field of food processing technology. The bacterial strains used for preparing Luocheng rice noodles include *Geotrichum candida* (…). Galactomyces candidum ) Mei3303.1, Pediococcus acidilactici ( Pediococcus acidilactici Mei.1103.1 and Lactobacillus paracasei ( Lactobacillus paracasei Both Mei1104.02 and Mei1104.02 have been deposited at the China General Microbiological Culture Collection Center. The beneficial effects of this invention are that by strengthening the fermentation process with compound microbial agents, it can improve fermentation efficiency, shorten fermentation time, inhibit the growth of other miscellaneous bacteria, and improve the flavor stability and safety of rice noodles.

The application belongs to the technical field of microbial application, and relates to a chiral L-lactic acid production engineering bacterium capable of selectively degrading racemic D-lactic acid and application of the chiral L-lactic acid production engineering bacterium. Pediococcus acidilactici The strain is classified and named as Pediococcus acidilactici LJ2071 and is preserved in the China Center for Type Culture Collection, has a preservation number of CCTCC M 20251230 and a preservation date of May 30, 2025. The strain has the ability to efficiently metabolize various types of biomass-derived monosaccharides and synthesize high-concentration and high-chirality L-lactic acid, has a certain degradation capacity for D-lactic acid contained in the fermentation raw material itself, and can use raw material containing a certain amount of racemic lactic acid to produce high-chirality L-lactic acid. When the concentration of racemic D-lactic acid in the fermentation liquor is not more than 1.5 g / L, the chirality of the L-lactic acid product is greater than 99.5%, and the L-lactic acid product can be used as a poly-lactic acid material polymerization monomer.

The invention discloses a method for degrading African swine fever viruses by fermenting pennisetum sinese with compound probiotics, which comprises the following steps: crushing a pennisetum sinese raw material polluted by the African swine fever viruses; the preparation method comprises the following steps: inoculating a compound probiotic leavening agent containing six specific strains (pichia membranaefaciens C200-1, brevibacillus reuteri RF10-5, pediococcus acidilactici, lactobacillus plantarum, lactobacillus buchneri and bifidobacterium), and fermenting for 6-14 days at 20-40 DEG C under a closed condition. By means of the fermentation process, polluted African swine fever viruses in materials can be effectively degraded, and q-PCR detection shows negative on the seventh day. The method is specially used for solving the problem of African swine fever virus pollution, is clear in effect, green, safe and easy to implement, and provides a feed link solution for prevention and control of African swine fever.

The invention belongs to the technical field of microorganisms, and relates to pediococcus acidilactici and application thereof. The preservation number of the pediococcus acidilactici AK-RS1 is CCTCC NO: M2025755, the pediococcus acidilactici AK-RS1 is excellent in acid resistance, alkali resistance, cholate resistance and trypsin resistance, the adhesion rate of the pediococcus acidilactici AK-RS1 to duck intestinal epithelial cells reaches 14.6%, and the pediococcus acidilactici AK-RS1 is sensitive to common antibiotics and high in safety.

The invention relates to the technical field of probiotics, in particular to pediococcus acidilactici NH3 for treating male prostate and improving sexual function as well as a culture method and application of the pediococcus acidilactici NH3. The strain is preserved in Guangdong Microbial Culture Collection Center on April 18, 2025, and the preservation number is GDMCC No: 66163. The strain is a probiotic strain approved by the National Health Commission. The strain has the effects of regulating intestinal flora balance and promoting digestion and absorption of a human body, and also has the effects of treating male prostate and improving the sexual function. 5 billion strains and 50 milligrams of metabolites are given every day, so that the endophytic essential quantity of astragaloside, spinosin and psoralen can be continuously provided in the intestinal reproduction and growth process, the male prostate can be treated, the sexual function can be improved, and the body health can be kept.

The invention discloses a method for producing gamma-aminobutyric acid through double-bacterium synergistic fermentation of lignocellulose hydrolysate, and belongs to the technical field of microbial engineering. The method comprises the following steps: constructing a recombinant pediococcus acidilactici (Pediococcus acidilactici FR-XY) engineering bacterium, and constructing a recombinant pediococcus acidilactici (Pediococcus acidilactici) FR-XY; the method comprises the following steps: carrying out staged fermentation culture on lactobacillus hilgardii FR-1012 and recombinant pediococcus acidilactici FR-XY by utilizing lignocellulose hydrolysate, so as to obtain mixed fermentation liquor; centrifuging the mixed fermentation liquor, collecting mixed thalli, resuspending the mixed thalli in a conversion solution containing L-glutamic acid and coenzyme 5-phosphopyridoxal, and carrying out whole-cell conversion reaction to obtain a conversion solution containing gamma-aminobutyric acid. According to the method, the lignocellulose hydrolysate can be utilized for double-bacterium synergistic fermentation, and full utilization of a multi-element carbon source in the lignocellulose hydrolysate and efficient synthesis of gamma-aminobutyric acid are achieved.

The application discloses a Pichia kluyveri strain, a Streptococcus lactis strain and application of co-fermentation of the two strains in coffee green bean degumming, and belongs to the technical field of microbial fermentation. The two strains (K123 and L135) are applied to co-fermentation in coffee green bean degumming, and can also be applied to preparation of coffee biological degumming preparation. When the compounding ratio of the strain compounding bacteria liquid is K123:L135=2:1, the fermentation temperature is 32 DEG C, the concentration is 10 7 CFU / mL, and the fermentation time is 36h, the pectinase activity can reach 982.985u / g, pectin can be effectively decomposed, biological degumming of coffee green beans can be realized, and the application prospect is good.

The present invention relates to a novel Pediococcus acidilactici WiKim0170 strain having immunity-enhancing efficacy and a composition for enhancing immunity, comprising same. In the present invention, it has been discovered that the Pediococcus acidilactici WiKim0170 strain, which is a novel strain derived from makgeolli, significantly increases spleen NK cell activity and increases inflammatory mediator, immunoglobulin, and cytokine production amounts, thereby improving an immunosuppressive reaction. In addition, the Pediococcus acidilactici WiKim0170 strain has been confirmed to increase the mRNA expression levels of iNOS, COX2, TNF-α, IL-1β, IL-6, IL-2, IL-12, and IL-10 in spleen tissue and increase the phosphorylation levels of NF-κB and IκBα, thereby having an effect of mitigating decreased immunity. Thus, according to the present invention, the composition comprising the Pediococcus acidilactici WiKim0170 strain, which is a novel strain derived from makgeolli, as an active ingredient is expected to be usefully employable as a pharmaceutical and functional food composition for enhancing immunity.